Tesi sul tema "Post-Cancer"
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Moore, Julie. "Cancer and post-traumatic growth". Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/171959/.
Holland, C. M. "Genomic and post-genomic studies in endometrial cancer". Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604158.
Simmons, Kingsley Lorraine. "The uptake of post-surgical treatment in cancer patients". Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416863.
Ooi, Li Yin. "Post-GWAS functional characterisation of colorectal cancer risk loci". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23514.
Swartzman, Samantha. "Psychosocial determinants of post-traumatic stress among cancer survivors". Thesis, University of Dundee, 2017. https://discovery.dundee.ac.uk/en/studentTheses/10d5554d-8987-436b-9558-4e6be5f844f2.
Patel, Uday. "Post chemoradiation re-staging of rectal cancer using MRI". Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/23905.
Wagner, Heidi. "Investigating post-translational modifications of c-Met in cancer". Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/203995/1/Heidi_Wagner_Thesis.pdf.
Longman, Michael Roy. "Combination of post-transcriptional and post-translational down-regulation of the oestrogen receptor in breast cancer". Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/54416/.
Djordjevic, Darja. "The Cancer War(d): Onco-Nationhood in Post-Traumatic Rwanda". Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493385.
Anthropology
Costanzo, Erin Susan. "Post-treatment adjustment and behavior change among women with breast cancer". Diss., University of Iowa, 2006. http://ir.uiowa.edu/etd/56.
Sebti, Salwa. "Rôle de la protéine BAT3 dans la signalisation cellulaire de l'autophagie". Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON1T028.
Autophagy, literally meaning self-eating, is a highly evolutionary conserved process in eukaryotes in which parts of the cytoplasm (organelles, macromolecules) are degraded by lysosomes. Basal autophagy is a quality control mechanism allowing the renewal of the cytoplasm but autophagy is also induced by cellular stress (starvation, hypoxia…) to improve cell survival. Autophagy has been implicated in several physiopathologies such as cancer or neurodegenerative diseases. Deregulations of autophagy may profoundly affect homeostasis.The purpose of my thesis is to explore the role of the nucleo-cytoplasmic shuttling protein BAT3 in autophagy and the mechanism of BAT3-dependent autophagy.Also known as BAG6 or Scythe, this 150 kDa protein is composed of various domain (UBL, Prolin-Rich, NLS, BAG) by which BAT3 interacts with multiple partners. The major of role BAT3 seems to be the protein quality control but BAT3 is also implicated in immunity and apoptosis. Our work demonstrates that the protein BAT3 is essential for basal and starvation-induced autophagy. We show that BAT3 regulation of autophagy is mediated by the modulation of p300 acetyltransferase intracellular localization and acetylation of two subtrates: p53 and the autophagy-related protein ATG7. Indeed, Bat3 allows: (i) the limitation of p300 into cytosol resulting in (ii) the maintenance of a low level of ATG7 acetylation and (iii) the increase of the starvation-induced p53 autophagy leading to the induction of autophagy
Kyung, Chan Park. "Pleiotropic roles, post-translational regulation and pharmacological targeting of NDRG1 in cancer". Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20146.
Scott, Michael David. "Fluorescent Polymer Based Post-Translational Differentiation and Subtyping of Cancer Cells". Diss., North Dakota State University, 2012. https://hdl.handle.net/10365/26680.
Shatley, Joseph Andrew, e L. Lee Glenn. "Sexuality and Quality of Life of Breast Cancer Patients Post Mastectomy". Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/7510.
Rivera, Vargas Thaiz Dayana. "La régulation post-transcriptionnelle des Cyclines D1, D3 et G1 par le complexe nucléaire IMP-3 dans les cancers humains". Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T055.
RNA-binding proteins of the IMP family (IGF2 mRNA-binding proteins 1-3) are key post-transcriptional regulatory factors of gene expression. They are known to control cell motility, adhesion, and proliferation. In our previous work, we show that all three IMP proteins can directly bind the mRNAs of cyclins D1, D3, and G1 (CCND1, D3, and G1) in vitro. Nevertheless, only IMP-3 regulates their expression in a significant manner in vivo, thus controlling proliferation of a number of human cancer cell lines. Importantly, the nuclear localization of IMP-3 is essential for the post-transcriptional regulation of the expression of CCND1, CCND3, and CCNG1 (CCNs). To elucidate the molecular mechanisms of IMP-3- specific regulation, we have identified its protein partners in human embryonic rhabdomyosarcoma (RMS) cells. We now show that in the nucleus and in the cytoplasm, IMP-3 interacts with a number or RNA-binding nucleocytoplasmic proteins, including DHX9, PTBP1, NF90, NF110, HNRNPA1, HNRNPA2/B1 and HuR. These IMP-3 partners have a dramatic impact on the protein levels of the cyclins. Interestingly, the decrease of CCNs protein synthesis in IMP-3 depleted cells can be fully reversed by down-regulating the key proteins of RNAi machinery, such as AGO2 and GW182. These findings suggest that IMP-3- dependent RNP complexes pre-assembled in the nucleus can protect their target mRNAs from cytoplasmic RNAi-dependent repression in human cancer cells
D'Urso, Anita. "Post-traumatic stress symptoms in young people with cancer and their siblings". Thesis, University of East Anglia, 2014. https://ueaeprints.uea.ac.uk/50725/.
Owusu, Miriam Sekyere. "Lymphedema, post breast cancer treatment at Komfo Anokye Teaching Hospital, Kumasi, Ghana". Thesis, Cape Peninsula University of Technology, 2011. http://hdl.handle.net/20.500.11838/2262.
To determine the incidence, risk factors and the treatment of lymphedema after breast cancer treatment at the oncology unit of KATH, Kumasi, Ghana from 01 January 2005 to 31 December 2008. Descriptive retrospective survey was used. Using a data capture sheet, data was collected from the medical records of the breast cancer patients. Breast cancer and lymphedema-related variables were collected. Data was analyzed as descriptive statistics. Chi-square test was applied to determine whether or not two variables are independent variables. Among 313 patients treated for breast cancer between 2005 and 2008, 31 (9.9%) developed lymphedema after treatment. A chi-square test showed that axillary lymph node dissection was statistically a significant risk factor of lymphedema (Chi-square test value=7.055, P value=0.008). Radiation and late stage of breast cancer diagnosis may have contributed in development of lymphedema despite having P value> 0.05. Age, body mass index (BMI) and hypertension were also not associated with lymphedema.
Chand, Manish. "The prognostic role of extramural venous invasion in post-chemoradiotherapy rectal cancer". Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/31467.
BELLAZZO, ARIANNA. "Tumor Suppressor DAB2IP as a target for post-transcriptional inactivation in cancer". Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908029.
Wall, David P. "Responding to localised prostate cancer : Lifeworld reconstruction during the first post-diagnostic year". Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2005. https://ro.ecu.edu.au/theses/655.
Hockett, Keri Ann. "The effects of a comprehensive post-treatment recovery program for breast cancer survivors". [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001256.
Askwith, Bryn Catherine. "Post-treatment exercise counseling and programming preferences of women living with breast cancer". Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31655.
Medicine, Faculty of
Graduate
Djoki´c, Tamara. "Identification of predictive models for treatment of neutropenia in post-chemotherapy cancer patients". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0020/MQ54615.pdf.
Colbourne, Linda Claire. "Testicular and prostate cancer : explaining the treatment and post treatment experience of couples". Thesis, University of Southampton, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419165.
Steyn, Beatrix Hendrina. "Surviving a laryngectomy : the experiences of post-operative cancer patients and their families". Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/95872.
ENGLISH ABSTRACT: Post-operative laryngectomy patients face various physical, psychological and social challenges. The comprehensive effects of a total laryngectomy can have an adverse impact on the patient and his or her family. Because improved medical treatment can increase the life expectancy of cancer sufferers, psychosocial guidance is required over an extended period. Unfortunately, limited information on the coping strategies of such patients is available. The social work profession could benefit from greater insight into the strengths and coping mechanisms of post-operative cancer patients in order to guide them through their survivorship journey with insight and compassion. The researcher therefore aimed to explore and describe the experience of a patient and his/her close family while coping with the long-term challenges of a laryngectomy. The objectives were: (1) to discuss the nature of cancer survivorship, (2) to describe the medical aspects of and physical re-adjustments to a laryngectomy, (3) to discuss principles and strategies for coping and surviving a laryngectomy, (4) to describe the comprehensive psychosocial effects during the permanent survival phase and re-entry into society; (5) to explore the survivorship journey of laryngectomy patients and their families, and (6) to analyse and interpret data obtained from the study. Each of the survivorship phases as contextualised by Miller et al. (2008:369-374)* is discussed in the literature review. Both the ecological and the strengths perspective were utilised as the theoretical framework for this study. Principles of the strengths perspective focus on the inherent strengths that help patients cope with this traumatic life event, while the ecological perspective focuses on the utilisation of community resources in order to survive the laryngectomy experience. A combination of exploratory and descriptive designs was applied throughout the study to gain insight into the survival experience of post-operative laryngectomy patients and their families. The research question was: “What are patients’ and families’ experiences of surviving a laryngectomy with the assistance of internal and external resources within the family system and environment?” This question was addressed by combining the quantitative and qualitative research approaches. Forty-five post laryngectomy patients and fifteen family members, representing one-third of these patients, were included in the study through purposive sampling. The study period was from June 2012 to July 2013. The inclusion criteria required: (1) Patients from the service area of the selected hospital who received a total laryngectomy as surgical treatment for an advanced stage of cancer of the larynx or hypopharynx; (2) patients who were operated on not less than three months previously; (3) patients who had already completed their initial treatment and who were attending the follow-up clinic; and (4) patients who had successfully acquired trachea-oesophageal speech. Data obtained from the interviews were organised into themes. Four themes were identified: (1) the need for pre-operative information; (2) experience of physical adjustment; (3) coping and strengths used; and (4) experience of psychosocial effects of surgery and re-entry into society. These themes were divided into sub-themes and categories. The main outcome of the study was that both patients and families mobilise a combination of inner strengths and external resources to adapt to the inevitable physical changes resulting from a laryngectomy. It is therefore recommended that social workers dealing with survivorship cases utilise a combination of the ecological and strengths perspectives to create an environment in which patients can explore their own inner strengths, or to help them link to community resources whilst coping with their survivorship journey. Future research should focus on the long-term psychosocial survival of laryngectomy patients and their families, as it is likely that survivorship will increase in future; the implementation of survivorship programmes for health care professionals to equip them with skills to guide cancer survivors to full utilisation of their own strengths and available community resources; the role of pre- and primary school children/grandchildren in the rehabilitation of laryngectomy patients deserves further investigation.
AFRIKAANSE OPSOMMING: Laringektomie-pasiënte word ná hul operasie met verskeie liggaamlike, psigiese en sosiale uitdagings gekonfronteer. Die omvattende gevolge van ‘n totale laringektomie kan die pasiënt en sy of haar gesin nadelig affekteer. Aangesien verbeterde mediese behandeling die lewensverwagting van kankerpasiënte kan verleng, word psigososiale ondersteuning oor ‘n langer tydperk benodig. Ongelukkig bestaan daar baie min inligting oor hoe pasiënte kanker hanteer. Die maatskaplike werk beroep kan dus voordeel trek uit beter insig in die hanteringsmeganismes van post-operatiewe kankerpasiënte om hulle met insig en empatie deur hul oorlewingsreis te kan begelei. Die navorser het ten doel gehad om die ondervindings van die kankerpasiënt en sy/haar naby familie tydens hul langtermynhantering van ‘n laringektomie te ondersoek en te beskrywe. Verdere oogmerke van die studie was: (1) om die aard van kankeroorlewing te bespreek; (2) om die mediese aspekte van en liggaamlike aanpassing ná ‘n laringektomie te beskrywe; (3) om die beginsels en strategieë vir ‘n oorwinning oor ‘n laringektomie te bespreek; (4) om die omvattende psigososiale gevolge van die finale oorlewingsfase en hertoetrede tot die gemeenskap te beskrywe; (5) om die oorlewingsreis van die laringektomiepasiënt en sy/haar gesin te ondersoek; en (6) om die resultate van die studie te ontleed en te interpreteer. Elk van die oorlewingsfases soos deur Miller et al. (2008:369-374)* beskrywe, is in die literatuuroorsig bespreek. Die ekologiese en die sterkte-perspektiewe is tesame as teoretiese raamwerk vir die studie gebruik. Die beginsels van die sterkte-perspektief is op die inherente krag van pasiënte gemik, om te bepaal hoe hulle hierdie traumatiese lewensgebeurtenis hanteer, terwyl die ekologiese perspektief op hul aanwending van gemeenskapsbronne om die laringektomie te oorleef, fokus. ‘n Kombinasie van ondersoekende en beskrywende navorsings ontwerpe is deurgaans gebruik om insig in die oorlewingstryd van laringektomiepasiënte en hul gesinne te verkry. Die navorsingsvraag was: “Wat is pasiënte en hul gesinne se ervarings van oorlewing na ‘n laringektomie met die hulp van interne en eksterne hulpbronne in die gesinstruktuur en omgewing?” Kwantitatiewe en kwalitatiewe navorsingsmetodes is gekombineer om hierdie vraag te ondersoek. Vyf-en-veertig laringektomiepasiënte en vyftien gesinslede, wat verteenwoordigend van twee-derdes van die pasiënte was, is met behulp van ‘n doelbewuste steekproef by die studie betrek. Die studie is tussen Junie 2012 en Julie 2013 onderneem. Die insluitingskriteria was: Pasiënte uit die diensgebied van die spesifieke hospitaal wat 'n totale laringektomie as chirurgiese behandeling vir 'n gevorderde stadium van kanker van die larinks of hipofarinks ontvang het; (2) pasiënte wat hul operasie nie meer as drie maande vantevore ondergaan het nie, (3) pasiënte wat reeds hul aanvanklike behandeling voltooi het en wat die opvolgkliniek bywoon, (4) pasiënte wat tragea-esofageale spraak suksesvol bemeester het. Die data, wat deur middel van onderhoude ingesamel is, is in temas gegroepeer. Vier temas is geïdentifiseer: (1) die behoefte aan inligting voor die operasie; (2) ervaring van liggaamlike aanpassing; (3) die hantering van omstandighede en innerlike krag; en (4) ervaring van die psigososiale uitwerking van die operasie en hertoetrede tot die gemeenskap. Hierdie temas is verder in subtemas en kategorieë verdeel. Die belangrikste uitkoms van hierdie studie is dat beide pasiënte en gesinne ‘n kombinasie van hul innerlike krag en eksterne bronne aangewend het om ná die laringektomie by die onafwendbare liggaamlike veranderinge aan te pas. Daar word dus aanbeveel dat maatskaplike werkers wat kankeroorlewendes hanteer, van ‘n kombinasie van die ekologiese en die sterkte-perspektief gebruik maak om ‘n omgewing te skep waarin die pasiënt sy of haar eie innerlike krag kan ontgin, of om pasiënte te help om kontak met gemeenskapsbronne te maak terwyl hulle die oorlewingsreis baasraak. Toekomstige navorsing behoort te fokus op langtermyn psigososiale oorlewing van laringektomie pasiënte en familie met inagneming van die tendens dat kanker pasiënte se oorlewing toeneem; die implementering van opleidingsprogramme vir gesondheidswerkers te fokus om hulle met die nodige kennis toe te rus om kankeroorlewendes te begelei om hul volle krag en alle beskikbare gemeenskapsbronne te gebruik. Daarby verdien die rol van voorskoolse- en laerskoolkinders in die rehabilitasie van laringektomiepasiënte verdere ondersoek.
Elgamal, Ola A. "TRANSCRIPTIONAL AND POST TRANSCRIPTIONAL REGULATION OF GENE EXPRESSION: APPLICATIONS TO BIOLOGY AND CANCER". The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461071345.
Mosquet, Guillaume. "L'analgésie post-opératoire par bupivacaïne interpleurale dans la chirurgie du cancer de l'oesophage". Caen, 1991. http://www.theses.fr/1991CAEN3128.
Allensworth-Davies, Donald. "Assessing localized prostate cancer post-treatment quality of life outcomes among gay men". Thesis, Boston University, 2012. https://hdl.handle.net/2144/12263.
Background: An estimated 2.3 million prostate cancer survivors reside in the United States, 50,000-70,000 of which are gay men. Fearing discrimination, stigma, or receipt of substandard care, gay men may not reveal their sexual orientation potentially affecting provider communication, treatment decision-making and post-treatment quality of life (QoL). Sexual orientation and other social factors may play an important role in men's QoL. Research suggests that functional impairments following treatment diminish QoL more for younger (i.e., age 50-64 years) than older men, while supportive partners can positively influence how men adapt to prostate cancer. Yet data are currently limited to heterosexual populations; it is unknown whether these effects are similar among gay prostate cancer survivors. Aims: To revise recent measures of prostate cancer QoL to include the experiences of gay men, assess the role of age and partnership status among gay men and compare QoL between gay and straight men. Methods: We administered a national QoL survey to gay prostate cancer survivors, including questions about sexual orientation disclosure and community rejection derived from qualitative interviews. Survey data were analyzed to assess the role of age and partnership status among gay men for four post-treatment prostate cancer QoL outcomes (masculine self-esteem, health worry, informed treatment decision and treatment regret) and QoL was then compared to straight prostate cancer survivors using data from a previous study to assess for differences based on sexual orientation. Results: Younger gay men experienced poorer QoL outcomes following treatment than older men; no association with partnership status was found. Comfort in revealing one's sexual orientation to a provider may result in better outcomes. Gay men reported more stigma, lower masculine self-esteem and more treatment regret following prostate cancer treatment than straight men. Conclusions: For gay men, greater sensitivity to stigma as a sexual minority may result in poorer QoL compared to straight men. While both gay and straight men struggle with similar QoL issues following localized prostate cancer treatment, gay men may have more difficulty due to sexual orientation. Further research is needed to better understand the role that sexual orientation and stigma play in prostate cancer QoL.
Rajandram, Rama Krsna. "Posttraumatic growth in oral cancer patients: a novel coping strategy". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44661691.
EL, Dhaybi Mohamad. "Déterminants moléculaires non-apoptotiques de l'activité oncogénique de Bcl-xL : rôle de la monodéamidation de Bcl-xL". Thesis, Limoges, 2017. http://www.theses.fr/2017LIMO0034/document.
Bcl-xL is an oncogene overexpressed in many types of cancer and which promotes cell survival by regulating two cellular processes : apoptosis and autophagy. We have recently identified a new form of this oncogene, which results from the deamidation of Asn52. This monodeamidated form is expressed under control conditions and is ubiquitously found in vitro and in vivo. Bcl-xL monodeamidation produces a mixture of proteins containing either an Asp residue or an IsoAsp residue in position 52. Our goal is to caracterise the functions of both species, and to determine how Bcl-xL monodeamidation modifies the survival functions of this oncogene. We have shown that the deamidomimetic mutant Bcl-xL N52DN66A retains the same anti-apoptotic function as the native protein, but exhibits enhanced autophagic activity and impaired clonogenic and tumorigenic properties in vitro, ex-vivo, and in vivo. We have studied certain of the mechanisms which can be involved in the regulation of autophagy and oncogenic properties of Bcl-xL such as mTor, Ras oncogene signaling pathway, metabolic activity measurement and stemness. We also implement in vitro assays to analyse the interactions established by isoAsp containing forms of Bcl-xL. Altogether our results support the view that deamidation regulates Bcl-xL oncogenic properties through apoptosis-independent mechanisms, and reinforce the importance of deciphering the non apoptotic functions of this protein to tackle its ability to sustain cell survival and drivecancer progression
Gouverneur, Amandine Andrée Denise Suzanne. "Evaluation post-commercialisation des médicaments en oncogériatrie : application au traitement du cancer colorectal métastatique". Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0887/document.
In France, in 2012, patients aged at least 65 years accounted for 71% of the incidence of ColoRectal Cancer (CCR). Since 2005, targeted therapies have been authorized in metastatic CRC (mCRC) and are recommended in first-line in combination with conventional chemotherapy. Given this lack of evaluation of these drugs in the elderly, the objective of this work was the study, in real-life setting, of the use, the benefits and the safety of anticancer drugs, including targeted therapies in elderly and/or frail mCRC patients. A systematic review of the literature confirmed the low inclusion of elderly and frail patients in clinical trials evaluating targeted therapies in the mCRC. According to a study on international pharmacovigilance data and the pooling of two field cohorts of patients treated by targeted therapies, we showed that their effectiveness and safety in the elderly were equivalent to those of the younger. In the cohort, frailty regarding serious adverse events and death was related to the characteristics of the mCRC. Finally, according to a pilot field study and a cohort in the French health insurance data, we have shown that, in the elderly, the treatment with anticancer drugs, including targeted therapies, was not optimal and still very related to the age of the patients. The benefit/risk ratio of targeted therapies therefore seems positive in the elderly population with mCRC currently treated. However, the elderly population treated does not seem to be fully matching with those who would benefit from treatment
JAMET, SERGE. "Les sarcomes post-radiques de la region thoracique apres irradiation pour cancer du sein". Nice, 1988. http://www.theses.fr/1988NICE6519.
Nduka, Charles. "Operative dissemination of cancer : the impact of microenvironmental manipulation on post-operative tumour growth". Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391634.
Redwood, Katie. "An exploration of gender differences in post-traumatic growth in survivors of colorectal cancer". Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/381737/.
Lelorain, Sophie. "Qualité de vie et développement post-traumatique à long terme d'un cancer du sein". Nantes, 2009. http://www.theses.fr/2009NANT3034.
Farashi, Samaneh. "Identification and characterisation of prostate cancer-associated genetic variations modulating the miRNA regulome". Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/210596/1/Samaneh_Farashi_Thesis.pdf.
Lacourt, Luis Eduardo. "A Phenomenological Exploration into the Resiliency of Prostate Cancer Survivors". ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/4971.
Johnson, Frank Phillip. "The impact of ablative facial cancer surgery and the affect of post-operative facial prostheses". Thesis, University of Sheffield, 2010. http://etheses.whiterose.ac.uk/12865/.
Wilson, Fiona. "Developing a decision aid for women considering post-treatment CA-125 testing for ovarian cancer". Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/26045.
Banthia, Rajni. "Post-treatment fatigue in breast cancer survivors : the role of sleep quality and depressed mood /". Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3130213.
Garcia, Amandine. "Régulation, par les microARNs, des gènes de prédisposition au cancer du sein BRCA". Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10159.
An absence or a reduction of the expression of the BRCA1 and BRCA2 breast cancer predisposition genes is found in one third of sporadic breast cancers. However, the mechanisms leading to the inactivation of their expression that have been already identified like the presence of somatic mutations, hypermethylation of the promoter or loss of heterozygosity at the BRCA loci are not sufficient to explain this large diminution. We therefore hypothesised that the expression of the BRCA genes could be regulated by microRNAs (miR). Following a bioinformatics analysis, validated by luciferase tests, we have shown a direct interaction of miR-146a and miR-146-b-5p with the 3’UTR of BRCA1. These miRs decrease the BRCA1 protein rate when they are overexpressed and increase it when they are inhibited. Furthermore we have demonstrated the role played by these miRs in cell proliferation and DNA repair by homologous recombination, two mechanisms for which BRCA1 is required. We have found these two miRs overexpressed in mammary cell lines and in triple-negative breast tumors that have a profile similar to that of the tumors developed by BRCA1 mutation carriers. In a second part, we analysed if these two microRNAs also play a role in familial breast cancers. An association study of the rs2910164 : G>C SNP located in the gene for miR-146a, has permitted us to show that its presence does not seem to modify the risk to develop breast cancer in BRCA1 and BRCA2 mutation carriers. We have also undertaken to determine if some miR genes could modify tumor risk in BRCA mutation carriers, and/or could represent new breast cancer predisposing alleles
Bellera, Carine A. "Hierarchical changepoint modeling of post-radiotherapy prostate-specific antigen (PSA) series in men with prostate cancer". Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100321.
Serial PSA measurements are rarely perfectly monotonic. The American Society for Therapeutic Radiology and Oncology (ASTRO) consensus panel defines biochemical failure as three consecutive PSA increases. I examined the sensitivity and specificity of the ASTRO criterion using simulations of realistic, sophisticated data sets, that accurately reflect the systematic and random variations observed in PSA series.
In a preliminary analysis, I estimated the underlying PSA trajectories in a cohort of 470 men treated with radiotherapy for localized prostate cancer. I exploited the flexibility of Bayesian hierarchical regression models to describe the individual PSA series, each with its own changepoint, and non-constant variance.
The estimates provided by the hierarchical model allowed me to simulate a large set of true PSA series. From these, I generated observed PSA series: each underlying PSA value was distorted by adding a realistic amount of 'noise'. To evaluate the performance of rules for biochemical failure, including the ASTRO criterion, I then compared the generated observed PSA series to the underlying true PSA series. My results suggest that another rule might outperform ASTRO. This simulation-based approach can be applied to evaluate other rules that purport to rapidly and accurately detect up (down) turns in noisy series, such as in other medical data, and in data series used to monitor economic trends.
Finally, I present a practical charting paper for physicians to record post-treatment PSA values of individual patients. The plotted serial values provide rapid and accurate estimates of the PSA doubling time, without any difficult computations.
Grant, Andriene Simone. "The Association between Hemoglobin Level and Cancer Incidence, Mortality and Inflammatory Biomarkers in Post-Menopausal Women". Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/301693.
Buttiglione, V. "THE ROLE OF MIR-340 IN POST-TRANSCRIPTIONAL REGULATION OF THE UPA-SYSTEM IN BREAST CANCER". Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/365720.
Lagauche, Jacqueline. "Résultats de la radiothérapie post-opératoire dans le traitement du cancer de l'endomètre stade 1 : étude d'une série de 89 cas". Bordeaux 2, 1989. http://www.theses.fr/1989BOR25318.
Bombil, Ifongo. "Incidental cancer in multinodular goiter post thyroidectomy". Thesis, 2015. http://hdl.handle.net/10539/18473.
The risk of malignancy in the background of multinodular goitre (MNG) approximates 7.2%. The gold standard for diagnosis of thyroid cancer is fine needle aspiration (FNA). Unsuccessful, inconclusive or suspicious result mandate further investigations. The concern is on benign FNA which would not necessitate thyroidectomy but carries a risk of missed malignancy. Aim To determine the percentage and histopathological subtype of incidental cancers in patients who had thyroidectomy for multinodular goitre (MNG). Method Records of patients who underwent thyroidectomy between January 2005 and December 2010 at Chris Hani Baragwanath Academic Hospital were retrospectively reviewed. Data retrieved included patients’ demography, type of thyroidectomy, thyroid function test, FNA cytology and final histopathological results. Results A total of 166 thyroidectomies were performed on 162 patients. Majority (139) of patients were females. The mean age was 46 years (ranging from 15 to 79 years). A total of 120 pre-operative FNAs were available for analysis and 78 FNA were suggestive of benign nodular goitre. 70 of benign FNA results were histologically confirmed to be MNG after thyroidectomy. Incidental malignancy was found in 4 out of 70 cases of MNG (5.7 %); all were papillary carcinomas and predominantly (75%) follicular variant. Conclusion The risk of missing cancer in the background of MNG was 5.7%. The commonest histological type of thyroid cancer found in MNG was papillary carcinoma (100%) with follicular variant being the most common subtype (75%).
Wu, Timothy H., e 巫孟叡. "Integrative Cancer Marker Discovery in Post Genomic Era". Thesis, 2006. http://ndltd.ncl.edu.tw/handle/90774634090036442043.
國立陽明大學
生物資訊研究所
94
Expressed Sequence Tags (ESTs) are cDNA sequences reverse transcribed from mRNAs, reflecting the gene transcript at the time of extraction. Thus, ESTs offer a tremendous amount of information valuable for gene profiling. As of the year 2006, the database of EST at NCBI (dbEST) hosts more than 7 million human cDNA sequences, invaluable for mining differentially expressed genes from various cancer tissues. Here, a new approach for expression profile is presented. Unlike the existing EST database mining tools, our method bypass common problems associated with EST clustering techniques and is more flexible in dataset selection and the final selection of significant genes. A number of known cancer markers were easily found in our analysis. In general, this new technology will be useful for the identification of previously uncharacterized genes and may be helpful for developing cancer diagnosis and therapeutic agents.
Schmidtmann, Frank. "Co- and post-translational synthesis towards carbohydrate based cancer vaccines /". 2005. http://wwwlib.umi.com/dissertations/fullcit/3149206.
Jing-HongGuo e 郭勁宏. "MicroRNAs Mediate Post-transcriptional Regulation of Pin1 in Prostate Cancer". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/07279735601378536767.
Rocha, Rafael Amorim. "Histone post-translational modifications and chromatin remodelers in colorectal cancer". Master's thesis, 2017. https://repositorio-aberto.up.pt/handle/10216/109416.