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Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 21 febbraio 2023

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1

Russo, Jackson, Jennifer Fiegel e Nicole K. Brogden. "Rheological and Drug Delivery Characteristics of Poloxamer-Based Diclofenac Sodium Formulations for Chronic Wound Site Analgesia". Pharmaceutics 12, n. 12 (15 dicembre 2020): 1214. http://dx.doi.org/10.3390/pharmaceutics12121214.

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Chronic wounds are a significant and growing health problem, and clinical treatment is often a painful experience. A topical dosage form would be optimal to treat this pain. Poloxamer 407, a thermosensitive polymer that is a liquid at low temperatures but gels at higher temperatures, is well suited to administer topical analgesics to chronic wound sites. The goal of this study was to evaluate the gelation and drug delivery properties of poloxamer 407 gels containing diclofenac sodium for potential use in chronic wound analgesic delivery. The gelation properties of poloxamer formulations were evaluated rheologically. Drug delivery properties of poloxamers loaded with diclofenac sodium were evaluated using snakeskin dialysis membranes, intact porcine ear skin, and porcine ear skin impaired via tape stripping. A commercial gel product and a solution of diclofenac sodium in water were used as control formulations. Poloxamer concentration and gelation temperature varied inversely, and the addition of higher concentrations of diclofenac sodium correlated to significant increases in poloxamer gelation temperature. Poloxamer solutions were effective in limiting the permeation of diclofenac sodium through membranes with impaired barrier properties, and delivery of diclofenac sodium from poloxamer 407 did not vary significantly from delivery observed from the commercial gel product. The amount of drug delivered in 24 h did not change significantly with changes in poloxamer 407 concentration. The results of this study indicate that poloxamer 407 may be a useful formulation component for administration of an analgesic product to a chronic wound site.

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Chen, Yabing, Jeong-Ho Lee, Mingyue Meng, Naiyu Cui, Chun-Yu Dai, Qi Jia, Eui-Seok Lee e Heng-Bo Jiang. "An Overview on Thermosensitive Oral Gel Based on Poloxamer 407". Materials 14, n. 16 (12 agosto 2021): 4522. http://dx.doi.org/10.3390/ma14164522.

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In this review, we describe the application of thermosensitive hydrogels composed of poloxamer in medicine, especially for oral cavities. Thermosensitive hydrogels remain fluid at room temperature; at body temperature, they become more viscous gels. In this manner, the gelling system can remain localized for considerable durations and control and prolong drug release. The chemical structure of the poloxamer triblock copolymer leads to an amphiphilic aqueous solution and an active surface. Moreover, the poloxamer can gel by forming micelles in an aqueous solution, depending on its critical micelle concentration and critical micelle temperature. Owing to its controlled-release effect, a thermosensitive gel based on poloxamer 407 (P407) is used to deliver drugs with different characteristics. As demonstrated in studies on poloxamer formulations, an increase in gelling viscosity decreases the drug release rate and gel dissolution time to the extent that it prolongs the drug’s duration of action in disease treatment. This property is used for drug delivery and different therapeutic applications. Its unique route of administration, for many oral diseases, is advantageous over traditional routes of administration, such as direct application and systemic treatment. In conclusion, thermosensitive gels based on poloxamers are suitable and have great potential for oral disease treatment.

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Vyas, Vikrant, Pankajkumar Sancheti, Poonam Karekar, Manali Shah e Yogesh Pore. "Physicochemical characterization of solid dispersion systems of tadalafil with poloxamer 407". Acta Pharmaceutica 59, n. 4 (1 dicembre 2009): 453–61. http://dx.doi.org/10.2478/v10007-009-0037-4.

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Physicochemical characterization of solid dispersion systems of tadalafil with poloxamer 407 Dissolution behaviour of a poorly water-soluble drug, tadalafil, from its solid dispersion systems with poloxamer 407 has been investigated. Solid dispersion systems of tadalafil were prepared with poloxamer 407 in 1:0.5, 1:1.5 and 1:2.5 ratios using the melting method. Characterization of binary systems with FTIR and XRPD studies demonstrated the presence of strong hydrogen bonding interactions, a significant decrease in crystallinity and the possibility of existence of amorphous entities of the drug. In the binary systems tested, 1:0.5 proportion of tadalafil/poloxamer 407 showed rapid dissolution of tadalafil (DE30 70.9 ± 3.6 %). In contrast, higher proportions of poloxamer 407 (1:1.5 and 1:2.5) offered no advantage towards dissolution enhancement of the drug, indicating altered rheological characteristics of the polymer at its higher concentration, which might have retarded the release rate of tadalafil.

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Raymond, Jean, Annick Metcalfe, Igor Salazkin e Alexander Schwarz. "Temporary vascular occlusion with poloxamer 407". Biomaterials 25, n. 18 (agosto 2004): 3983–89. http://dx.doi.org/10.1016/j.biomaterials.2003.10.085.

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5

Fakhari, Amir, Marta Corcoran e Alexander Schwarz. "Thermogelling properties of purified poloxamer 407". Heliyon 3, n. 8 (agosto 2017): e00390. http://dx.doi.org/10.1016/j.heliyon.2017.e00390.

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6

Risselada, Marije, Joanne L. Tuohy, Mac Law, Mindi L. James e B. Duncan X. Lascelles. "Local Administration of Carboplatin in Poloxamer 407 After an Ulnar Osteosarcoma Removal in a Dog". Journal of the American Animal Hospital Association 56, n. 6 (28 ottobre 2020): 325. http://dx.doi.org/10.5326/jaaha-ms-6926.

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ABSTRACT An 8 yr old male castrated hound presented for a left distal ulnar osteosarcoma. Staging (computed tomography and nuclear scintigraphy) did not reveal any metastases. A limb-sparing ulnectomy with local adjunctive carboplatin in a poloxamer copolymer gel (poloxamer 407) was performed. The patient recovered without complications after surgery. No wound healing complications or adverse effects occurred after local use of carboplatin in poloxamer 407. The local recurrence-free interval was 296 days from surgery, and the survival time was 445 days from initial diagnosis. This is the first report in the veterinary literature of using poloxamer 407 as a carrier for local delivery of chemotherapeutic drugs in a clinical patient.

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7

Ćirin, Dejan, Veljko Krstonošić e Darija Sazdanić. "Synergism and antagonism in mixed monolayers: Brij S20/poloxamer 407 and Triton X-100/poloxamer 407 mixtures". Fluid Phase Equilibria 473 (ottobre 2018): 220–25. http://dx.doi.org/10.1016/j.fluid.2018.06.009.

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8

Wang, Wen Yi, Patrick Chi Leung Hui, Frency S. F. Ng, Chi Wai Kan, Clara B. S. Lau e Ping Chung Leung. "Application of Thermosensitive Poloxamer-Based Hydrogel in the Development of Transdermal Therapy Containing Herbal Medicine". Key Engineering Materials 719 (novembre 2016): 57–61. http://dx.doi.org/10.4028/www.scientific.net/kem.719.57.

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Poloxamer 407 exhibits remarkable reversible sol gel transition which makes it attractive and promising in the application of transdermal therapy. This study mainly reports the skin permeation properties of model drug from poloxamer 407 based transdermal hydrogel therapy with the presence of chemical penetration enhancers. Poloxamer 407 based hydrogel was shown porous structure which faciliates the diffusional release of model drug. Compared with borneol and 1,2-propanediol, azone was the most effective enhancer for gallic acid skin permeation, and 3% of azone presented the optimal enhancement effect. This study also demonstrated that the selection of enhancers is of great importance for the skin permeation of model drug.

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9

Gil, Hyung-Jun, Hyun Kim e Sang-Cheol Chi. "Release of flurbiprofen from poloxamer 407 gel". Archives of Pharmacal Research 17, n. 4 (agosto 1994): 240–43. http://dx.doi.org/10.1007/bf02980454.

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10

Hong, Sung-Sil, Eun-Hwa Sohn, Jin-Woo Lee, Yun-A. Park, Sung-Hyeok Kim, So-Hee Jang, Chang-Woo Ha, Mi-Ja Kim, Seung Namkoong e Hyun-Jung Koo. "Preventive Effects of Red Ginseng on Poloxamer-407 Induced Dyslipidemic Mice". Journal of the Korea Academia-Industrial cooperation Society 22, n. 10 (31 ottobre 2021): 43–51. http://dx.doi.org/10.5762/kais.2021.22.10.43.

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11

Gilinsky, Michael A., Thomas P. Johnston, Natalia A. Zhukova, Nina I. Dubrovina, Tatyana V. Latysheva, Sergey E. Naumenko e Roman A. Sukhovershin. "Methylated arginine analogues: their potential role in atherosclerosis and cognition using the poloxamer-407-induced mouse model of dyslipidemia". Canadian Journal of Physiology and Pharmacology 94, n. 11 (novembre 2016): 1122–31. http://dx.doi.org/10.1139/cjpp-2016-0104.

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An experimental mouse model of dyslipidemia and atherosclerosis was utilized to study the generation of methylarginines in vivo, as well as any potential behavioral changes in mice associated with the production of excess methylarginines. Following 14 weeks of poloxamer 407 treatment, mice developed atherosclerosis and the plasma concentrations of monomethylarginine and asymmetric dimethylarginine were found to be significantly greater than corresponding concentrations in control mice. This finding may have contributed to the development of aortic atherosclerotic lesions in poloxamer-treated mice by interfering with nitric oxide availability and, hence, normal function of vascular endothelium. Poloxamer-407-treated mice also showed a significant decrease in locomotor and exploratory activity, together with signs of emotional stress and anxiety relative to controls. Passive avoidance testing to assess learning and memory provided suggestive evidence that poloxamer-treated mice could potentially be characterized as having undergone a disruption in the process of forgetting about an aversive event, specifically, a foot shock, when compared with control mice. Thus, it is also suggested that the increase in both plasma monomethylarginine and asymmetric dimethylarginine in poloxamer-407-treated mice may somehow influence learning and memory, because endothelial dysfunction caused by reduced nitric oxide availability has been hypothesized to negatively influence cognitive function.

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12

Sguizzato, Maddalena, Alessia Pepe, Anna Baldisserotto, Riccardo Barbari, Leda Montesi, Markus Drechsler, Paolo Mariani e Rita Cortesi. "Niosomes for Topical Application of Antioxidant Molecules: Design and In Vitro Behavior". Gels 9, n. 2 (26 gennaio 2023): 107. http://dx.doi.org/10.3390/gels9020107.

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In the present study, gels based on xanthan gum and poloxamer 407 have been developed and characterized in order to convey natural antioxidant molecules included in niosomes. Specifically, the studies were conducted to evaluate how the vesicular systems affect the release of the active ingredient and which formulation is most suitable for cutaneous application. Niosomes, composed of Span 20 or Tween 20, were produced through the direct hydration method, and therefore, borate buffer or a micellar solution of poloxamer 188 was used as the aqueous phase. The niosomes were firstly characterized in terms of morphology, dimensional and encapsulation stability. Afterwards, gels based on poloxamer 407 or xanthan gum were compared in terms of spreadability and adhesiveness. It was found to have greater spreadability for gels based on poloxamer 407 and 100% adhesiveness for those based on xanthan gum. The in vitro diffusion of drugs studied using Franz cells associated with membranes of mixed cellulose esters showed that the use of a poloxamer micellar hydration phase determined a lower release as well as the use of Span 20. The thickened niosomes ensured controlled diffusion of the antioxidant molecules. Lastly, the in vivo irritation test confirmed the safeness of niosomal gels after cutaneous application.

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13

Giuliano, Elena, Donatella Paolino, Massimo Fresta e Donato Cosco. "Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview". Pharmaceutics 10, n. 3 (12 settembre 2018): 159. http://dx.doi.org/10.3390/pharmaceutics10030159.

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Poloxamer 407, also known by the trademark Pluronic® F127, is a water-soluble, non-ionic triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) between the two hydrophilic units of polyoxyethylene (POE). Poloxamer 407-based hydrogels exhibit an interesting reversible thermal characteristic. That is, they are liquid at room temperature, but they assume a gel form when administered at body temperature, which makes them attractive candidates as pharmaceutical drug carriers. These systems have been widely investigated in the development of mucoadhesive formulations because they do not irritate the mucosal membranes. Based on these mucoadhesive properties, a simple administration into a specific compartment should maintain the required drug concentration in situ for a prolonged period of time, decreasing the necessary dosages and side effects. Their main limitations are their modest mechanical strength and, notwithstanding their bioadhesive properties, their tendency to succumb to rapid elimination in physiological media. Various technological approaches have been investigated in the attempt to modulate these properties. This review focuses on the application of poloxamer 407-based hydrogels for mucosal drug delivery with particular attention being paid to the latest published works.

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14

Lee, Unji, Mi Hye Kwon e Hee Eun Kang. "Pharmacokinetic alterations in poloxamer 407-induced hyperlipidemic rats". Xenobiotica 49, n. 5 (8 maggio 2018): 611–25. http://dx.doi.org/10.1080/00498254.2018.1466212.

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15

PALMER, WARREN K., EUGENE E. EMESON e THOMAS P. JOHNSTON. "The poloxamer 407-induced hyperlipidemic atherogenic animal model". Medicine &amp Science in Sports &amp Exercise 29, n. 11 (novembre 1997): 1416–21. http://dx.doi.org/10.1097/00005768-199711000-00005.

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16

Ricci, E. J., M. V. L. B. Bentley, M. Farah, R. E. S. Bretas e J. M. Marchetti. "Rheological characterization of Poloxamer 407 lidocaine hydrochloride gels". European Journal of Pharmaceutical Sciences 17, n. 3 (novembre 2002): 161–67. http://dx.doi.org/10.1016/s0928-0987(02)00166-5.

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17

Veyries, M. L., G. Couarraze, S. Geiger, F. Agnely, L. Massias, B. Kunzli, F. Faurisson e B. Rouveix. "Controlled release of vancomycin from Poloxamer 407 gels". International Journal of Pharmaceutics 192, n. 2 (dicembre 1999): 183–93. http://dx.doi.org/10.1016/s0378-5173(99)00307-5.

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18

Ricci, E. J., L. O. Lunardi, D. M. A. Nanclares e J. M. Marchetti. "Sustained release of lidocaine from Poloxamer 407 gels". International Journal of Pharmaceutics 288, n. 2 (gennaio 2005): 235–44. http://dx.doi.org/10.1016/j.ijpharm.2004.09.028.

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19

Lakshmi, PK, e K. Harini. "Design and Optimization of Thermo-reversible Nasal in situ Gel of Atomoxetine Hydrochloride Using Taguchi Orthogonal Array Design". Dhaka University Journal of Pharmaceutical Sciences 18, n. 2 (22 settembre 2019): 183–93. http://dx.doi.org/10.3329/dujps.v18i2.43261.

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The present investigation was aimed to develop a thermo-reversible nasal in situ gel of atomoxetine hydrochloride (AH) with reduced nasal muco-ciliary clearance in order to improve residence time and targeting the brain through nasal mucosa for the treatment of attention-deficit hyperactivity disorder (ADHD). In situ gel formulations were prepared using different concentrations of the thermo-gelling poloxamer 407 and mucoadhesive polymers. Temperature-triggered ionic gelation is the mechanism involved. Taguchi L9 OA experimental design was employed for the optimization of the effect of independent variables (Poloxamer 407 and Carbopol 934P) on the response (gelation temperature). In situ gel formulation F4 having 20% poloxamer 407 and 0.3% carbopol 934P and formulation F6 having 20% poloxamer 407 and 0.2% HPMC K100 were optimized based on evaluation parameters. The gelation temperature of F4 and F6 was found to be 37°C ± 0.4 and 37°C ± 0.2, drug content 98.34 and 98.33% and drug release was 83.18, 82.4% in 4 hrs with a flux of 436.9 and 428.1 μg.cm2/hr, respectively. The release pattern of drug followed first-order kinetics with Higuchi release mechanism. The value of ‘n’ from Korsemeyer equation indicated the anomalous diffusional drug release. This study concluded that in situ gel enhanced the nasal residence time and thus may improve the bioavailability of the drug through nasal route by avoiding first pass metabolism Dhaka Univ. J. Pharm. Sci. 18(2): 183-193, 2019 (December)

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Cristiano, Maria Chiara, Francesca Froiio, Antonia Mancuso, Federica De Gaetano, Cinzia Anna Ventura, Massimo Fresta e Donatella Paolino. "The Rheolaser Master™ and Kinexus Rotational Rheometer® to Evaluate the Influence of Topical Drug Delivery Systems on Rheological Features of Topical Poloxamer Gel". Molecules 25, n. 8 (23 aprile 2020): 1979. http://dx.doi.org/10.3390/molecules25081979.

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Poloxamer 407 copolymer is a versatile and widely used thermo-reversible material. Its use has many advantages, such as bio-adhesion, enhanced solubilization of poorly water-soluble drugs and many applications fields like oral, rectal, topical, nasal drug administration. Hydrogels made up of Poloxamer 407 are characterized by specific rheological features, which are affected by temperature, concentration and presence of other compounds. A strategic approach in topical therapeutic treatments may be the inclusion of drug delivery systems, such as ethosomes, transfersomes and niosomes, into hydrogel poloxamer formulation. The evaluation of the interaction between colloidal carriers and the Poloxamer 407 hydrogel network is essential for a suitable design of an innovative topical dosage form. For this reason, the Rheolaser Master™, based on diffusing wave spectroscopy, and a Kinexus Rotational Rheometer were used to evaluate the influence of nanocarriers on the microrheological features of hydrogels. The advantages of the Rheolaser Master™ analyzer are: (i) its ability to determine viscoelastic parameter, without altering or destroying the sample and at rest (zero shear); (ii) possibility of aging analysis on the same sample. This study provide evidence that vesicular systems do not influence the rheological features of the gel, supporting the possibility to encapsulate an innovative system into a three-dimensional network.

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Lucia, Alejandro, Ariel Ceferino Toloza, Eduardo Guzmán, Francisco Ortega e Ramón G. Rubio. "Novel polymeric micelles for insect pest control: encapsulation of essential oil monoterpenes inside a triblock copolymer shell for head lice control". PeerJ 5 (20 aprile 2017): e3171. http://dx.doi.org/10.7717/peerj.3171.

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BackgroundEssential oil components (EOCs) are molecules with interesting application in pest control, these have been evaluated against different insect pest from more than 100 years, but their practical use is rather limited. Thus, the enhancement of their bioavailability and manageability due to their dispersion in water can open new perspective for the preparation of formulations for the control of insect pest. In this work, we studied the encapsulation of different monoterpenes in a poloxamer shell in order to prepare aqueous formulations that can be used for the development of platforms used in pest control.MethodsMicellar systems containing a 5 wt% of poloxamer 407 and 1.25 wt% of the different monoterpenes were prepared. Dynamic Light Scattering (DLS) experiments were carried out to characterize the dispersion of the EOCs in water. The pediculicidal activity of these micellar systems was tested on head lice using anex vivoimmersion test.ResultsThe poloxamers allowed the dispersion of EOCs in water due to their encapsulation inside the hydrophobic core of the copolymer micelles. From this study, we concluded that it is possible to make stable micellar systems containing water (>90 wt%), 1.25 wt% of different monoterpenes and a highly safe polymer (5wt% Poloxamer 407). These formulations were effective against head lice with mortality ranging from 30 to 60%, being the most effective emulsions those containing linalool, 1,8-cineole,α-terpineol, thymol, eugenol, geraniol and nonyl alcohol which lead to mortalities above 50%.DiscussionSince these systems showed good pediculicidal activity and high physicochemical stability, they could be a new route for the green fabrication of biocompatible and biosustainable insecticide formulations.

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Yang, Xuanxin, Rongshuai Yang, Min Chen, Qingde Zhou, Yingying Zheng, Chao Lu, Jianing Bi et al. "KGF-2 and FGF-21 poloxamer 407 hydrogel coordinates inflammation and proliferation homeostasis to enhance wound repair of scalded skin in diabetic rats". BMJ Open Diabetes Research & Care 8, n. 1 (maggio 2020): e001009. http://dx.doi.org/10.1136/bmjdrc-2019-001009.

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ObjectiveThe present study focused on the development of a poloxamer 407 thermosensitive hydrogel loaded with keratinocyte growth factor-2 (KGF-2) and fibroblast growth factor-21 (FGF-21) as a therapeutic biomaterial in a scald-wound model of type-2 diabetes in Goto-Kakizaki (GK) rats.Research design and methodsIn this study, a poloxamer 407 thermosensitive hydrogel loaded with KGF-2 and/or FGF-21 was prepared and its physical and biological properties were characterized. The repairing effects of this hydrogel were investigated in a scald-wound model of type-2 diabetes in GK rats. The wound healing rate, epithelialization, and formation of granulation tissue were examined, and biomarkers reflecting regulation of proliferation and inflammation were quantified by immunostaining and Western blotting. T tests and analyses of variance were used for statistical analysis via Graphpad Prism V.6.0.ResultsA 17.0% (w/w) poloxamer 407 combined with 1.0% (w/w) glycerol exhibited controlled release characteristics and a three-dimensional structure. A KGF-2/FGF-21 poloxamer hydrogel promoted cellular migration without apoptosis. This KGF-2/FGF-21 poloxamer hydrogel also accelerated wound healing of scalded skin in GK rats better than that of a KGF-2 or FGF-21 hydrogel alone due to accelerated epithelialization, formation of granulation tissue, collagen synthesis, and angiogenesis via inhibition of inflammatory responses and increased expression of alpha-smooth muscle actin (α-SMA), collagen III, pan-keratin, transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF), and CD31.ConclusionsA KGF-2/FGF-21 poloxamer hydrogel accelerated wound healing of scalded skin in GK rats, which was attributed to a synergistic effect of KGF-2-mediated cellular proliferation and FGF-21-mediated inhibition of inflammatory responses. Taken together, our findings provide a novel and potentially important insight into improving wound healing in patients with diabetic ulcers.

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Padula, Cristina, Ian Pompermayer Machado, Aryane Alves Vigato e Daniele Ribeiro de Araujo. "New Strategies for Improving Budesonide Skin Retention". Pharmaceutics 14, n. 1 (24 dicembre 2021): 30. http://dx.doi.org/10.3390/pharmaceutics14010030.

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The aim of this work was to evaluate the ex vivo effect of the combination of two strategies, complexation with cyclodextrin, and poloxamer hydrogels, for improving water solubility in the dermal absorption of budesonide. Two hydrogels containing 20% poloxamer 407, alone or in combination with poloxamer 403, were prepared. Each formulation was loaded with 0.05% budesonide, using either pure budesonide or its inclusion complex with hydroxypropyl-β-cyclodextrin, and applied in finite dose conditions on porcine skin. The obtained results showed that for all formulations, budesonide accumulated preferentially in the epidermis compared to the dermis. The quantity of budesonide recovered in the receptor compartment was, in all cases, lower than the LOQ of the analytical method, suggesting the absence of possible systemic absorption. The use of a binary poloxamer mixture reduced skin retention, in line with the lower release from the vehicle. When the hydrogels were formulated with the inclusion complex, an increase in budesonide skin retention was observed with both hydrogels. Poloxamer hydrogel proved to be a suitable vehicle for cutaneous administration of budesonide.

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Giuliano, Elena, Donatella Paolino, Maria Chiara Cristiano, Massimo Fresta e Donato Cosco. "Rutin-Loaded Poloxamer 407-Based Hydrogels for In Situ Administration: Stability Profiles and Rheological Properties". Nanomaterials 10, n. 6 (31 maggio 2020): 1069. http://dx.doi.org/10.3390/nano10061069.

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Rutin is a flavone glycoside contained in many plants, and exhibits antioxidant, anti-inflammatory, anticancer, and wound-healing properties. The main disadvantage related to the use of this molecule for pharmaceutical application is its poor bioavailability, due to its low solubility in aqueous media. Poloxamer 407-hydrogels show interesting thermo-sensitive properties that make them attractive candidates as pharmaceutical formulations. The hydrophobic domains in the chemical structure of the copolymer, a polymer made up of two or more monomer species, are useful for retaining poorly water-soluble compounds. In this investigation various poloxamer 407-based hydrogels containing rutin were developed and characterized as a function of the drug concentration. In detail, the Turbiscan stability index, the micro- and dynamic rheological profiles and in vitro drug release were investigated and discussed. Rutin (either as a free powder or solubilized in ethanol) did not modify the stability or the rheological properties of these poloxamer 407-based hydrogels. The drug leakage was constant and prolonged for up to 72 h. The formulations described are expected to represent suitable systems for the in situ application of the bioactive as a consequence of their peculiar versatility.

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Seo, Hee Jin, e Jin-Chul Kim. "Effects of additives on phase transitions of Poloxamer 407/Poloxamer 188 mixture and release property of monoolein cubic phase containing the poloxamers". Journal of Industrial and Engineering Chemistry 18, n. 1 (gennaio 2012): 88–91. http://dx.doi.org/10.1016/j.jiec.2011.11.077.

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Zhang, Wen, Chuiguo Sun, Junxiong Zhu, Weifang Zhang, Huijie Leng e Chunli Song. "3D printed porous titanium cages filled with simvastatin hydrogel promotes bone ingrowth and spinal fusion in rhesus macaques". Biomaterials Science 8, n. 15 (2020): 4147–56. http://dx.doi.org/10.1039/d0bm00361a.

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Kadam, Pooja, Vitthal Chaware e Vivek Redasani. "Evaluation of Anti-hyperlipidemic Activity of Red Onion In Experimental Animals". Asian Journal of Pharmaceutical Research and Development 9, n. 4 (14 agosto 2021): 52–62. http://dx.doi.org/10.22270/ajprd.v9i4.988.

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Objective: To evaluate antihyperlipidemic effect of red onion on poloxamer 407 induced hyperlipidemia in wistar albino rats. Methods: Hyperlipidemia was induced by intraperitoneal injection of poloxamer-407 (P-407) at a dose of 1.0g/kg body weight in wistar albino rats. Drug treatments were done by oral gavage for 21 days. At the end of the study, animals were kept fasted over night and then blood samples were collected. The serum total cholesterol (TC), triglycerides (TG), and High density lipoprotein (HDL) were measured while low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were calculated by Friedewald formula and atherogenic index was also calculated. Results: From the present investigation, it was observed that ethanolic extract of red onion have shown significant reduction in serum cholesterol, triglyceride and lipoprotein levels and increase in HDL level in P-407 induced hyperlipidemia. Conclusion: The findings in this study revealed the effectiveness of ethanolic extract of red onion against hyperlipidemic activity.

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Palmer, Warren K., Eugene E. Emeson e Thomas P. Johnston. "Poloxamer 407-induced atherogenesis in the C57BL/6 mouse". Atherosclerosis 136, n. 1 (gennaio 1998): 115–23. http://dx.doi.org/10.1016/s0021-9150(97)00193-7.

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Jansen, Mark M. P. M., Jacques M. Verzijl, David M. Burger e Yechiel A. Hekster. "Controlled release of morphine from a poloxamer 407 gel". International Journal of Pharmaceutics 452, n. 1-2 (agosto 2013): 266–69. http://dx.doi.org/10.1016/j.ijpharm.2013.05.032.

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Moura, Sofia, Jennifer Noro, Patrícia Cerqueira, Carla Silva, Artur Cavaco-Paulo e Ana Loureiro. "Poloxamer 407 based-nanoparticles for controlled release of methotrexate". International Journal of Pharmaceutics 575 (febbraio 2020): 118924. http://dx.doi.org/10.1016/j.ijpharm.2019.118924.

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Johnston, Thomas P., e Warren K. Palmer. "Mechanism of poloxamer 407-induced hypertriglyceridemia in the rat". Biochemical Pharmacology 46, n. 6 (settembre 1993): 1037–42. http://dx.doi.org/10.1016/0006-2952(93)90668-m.

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Lee, Kayoung, Sang-Chul Shin e Injoon Oh. "Fluorescence spectroscopy studies on micellization of poloxamer 407 solution". Archives of Pharmacal Research 26, n. 8 (agosto 2003): 653–58. http://dx.doi.org/10.1007/bf02976716.

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33

Dumortier, Gilles, Jean Louis Grossiord, Florence Agnely e Jean Claude Chaumeil. "A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics". Pharmaceutical Research 23, n. 12 (11 novembre 2006): 2709–28. http://dx.doi.org/10.1007/s11095-006-9104-4.

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Wang, Jian, Bingkun Zhao, Lili Sun, Liqun Jiang, Qiang Li e Peisheng Jin. "Smart thermosensitive poloxamer hydrogels loaded with Nr-CWs for the treatment of diabetic wounds". PLOS ONE 17, n. 12 (30 dicembre 2022): e0279727. http://dx.doi.org/10.1371/journal.pone.0279727.

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Abstract (sommario):

The treatment of diabetic wound is a focus issue. At present, the Nocardia rubra cell wall skeleton (Nr-CWS) has been proved proven to promote angiogenesis and wound repair. Unfortunately, the high-glucose diabetic wound environment makes many drugs unable to be released effectively, and soon be removed. Smart thermosensitive poloxamer hydrogel (TH) is an ideal and adjustable drug delivery platform compatible with most living tissues. Here, a multifunctional composite thermosensitive hydrogel was developed. A mixture of poloxamers 407 and 188 as the gel matrix, and then it was physically mixed with Nr-CWS. The delivery vehicle not only controlled its release stably, preventing degradation in vitro, but also showed good affinity in vitro. In vivo, compared with thermosensitive poloxamer hydrogel alone or the direct use of Nr-CWS, the thermosensitive poloxamer hydrogel loaded with Nr-CWS promoted the proliferation of vascular endothelial cells effectively, resulting in increased expression of derma-related structural proteins and enhanced angiogenesis and wound healing. This study indicated that the angiogenesis and skin regeneration brought by Nr-CWS hydrogel are related to the activation of phosphatidylinositol 3 kinase and protein kinase B, Janus kinase/signal transducer and activator of transcription, and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling pathways.

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Priprem, Aroonsri, Chatchanok Nukulkit, Nutjaree Pratheepawanit Johns, Teerasak Damrongrungruang, Nanthiya Wongsangta e Em On Benjavongkulchai. "Effect of Polymeric Combinations on Mucoadhesive and Swelling Properties of Orabase Gel Formulations". Advanced Materials Research 853 (dicembre 2013): 3–8. http://dx.doi.org/10.4028/www.scientific.net/amr.853.3.

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Abstract (sommario):

Topical oral dosage form for anti-inflammation in the oral cavity provides convenience and patient compliance. Formulations of orabase gels composed of poloxamer 407, PVP, PVA, SCMC and/or white petrolatum (WP) and hydrocarbon gel (HG) were investigated for in vitro swelling and mucoadhesion for incorporation of melatonin. The highest detachment time of 18 h with an optimized swelling ratio of 1.3 was obtained from a gel with 55% of WP and HG in the presence of poloxamer 407 and PVP 90. In conclusion, an optimum balancing ratio between hydrocarbons and bioadhesive polymer parts is required to obtain mucoadhesive characteristics of the oral gel.

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Abou-Shamat, Mohamad A., Jacqueline L. Stair, Stewart B. Kirton, Jesus Calvo-Castro e Michael T. Cook. "A Design-of-Experiments approach to developing thermoresponsive gelators from complex polymer mixtures". Molecular Systems Design & Engineering 5, n. 9 (2020): 1538–46. http://dx.doi.org/10.1039/d0me00093k.

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37

Yan, Ca. "Genistein-loaded poloxamer 403/407 mixed micelles: preparation and pharmacokinetic study in rats". Journal of Chinese Pharmaceutical Sciences 27, n. 5 (20 maggio 2018): 342–51. http://dx.doi.org/10.5246/jcps.2018.05.035.

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38

Sguizzato, Maddalena, Paolo Mariani, Francesca Ferrara, Markus Drechsler, Supandeep Singh Hallan, Nicolas Huang, Fanny Simelière et al. "Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid". Nanomaterials 10, n. 5 (18 maggio 2020): 961. http://dx.doi.org/10.3390/nano10050961.

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Abstract (sommario):

Caffeic acid is a natural antioxidant, largely distributed in plant tissues and food sources, possessing anti-inflammatory, antimicrobial, and anticarcinogenic properties. The object of this investigation was the development of a formulation for caffeic acid cutaneous administration. To this aim, caffeic acid has been loaded in solid lipid nanoparticles by hot homogenization and ultrasonication, obtaining aqueous dispersions with high drug encapsulation efficiency and 200 nm mean dimension, as assessed by photon correlation spectroscopy. With the aim to improve the consistence of the aqueous nanodispersions, different types of polymers have been considered. Particularly, poloxamer 407 and hyaluronic acid gels containing caffeic acid have been produced and characterized by X-ray and rheological analyses. A Franz cell study enabled to select poloxamer 407, being able to better control caffeic acid diffusion. Thus, a nanoparticulate gel has been produced by addition of poloxamer 407 to nanoparticle dispersions. Notably, caffeic acid diffusion from nanoparticulate gel was eight-fold slower with respect to the aqueous solution. In addition, the spreadability of nanoparticulate gel was suitable for cutaneous administration. Finally, the antioxidant effect of caffeic acid loaded in nanoparticulate gel has been demonstrated by ex-vivo evaluation on human skin explants exposed to cigarette smoke, suggesting a protective role exerted by the nanoparticles.

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Fabbri, Julia, Patricia Eugenia Pensel, Clara María Albani, Lurdes Milagros Lopez, Analia Simonazzi, José María Bermudez, Santiago Daniel Palma e María Celina Elissondo. "Albendazole solid dispersions against alveolar echinococcosis: a pharmacotechnical strategy to improve the efficacy of the drug". Parasitology 147, n. 9 (27 aprile 2020): 1026–31. http://dx.doi.org/10.1017/s0031182020000670.

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Abstract (sommario):

AbstractAlveolar echinococcosis is a neglected parasitic zoonosis caused by Echinococcus multilocularis. The pharmacological treatment is based on albendazole (ABZ). However, the low water solubility of the drug produces a limited dissolution rate, with the consequent failure in the treatment of the disease. Solid dispersions are a successful pharmacotechnical strategy to improve the dissolution profile of poorly water-soluble drugs. The aim of this work was to determine the in vivo efficacy of ABZ solid dispersions using poloxamer 407 as a carrier (ABZ:P407 solid dispersions (SDs)) in the murine intraperitoneal infection model for secondary alveolar echinococcosis. In the chemoprophylactic efficacy study, the ABZ suspension, the ABZ:P407 SDs and the physical mixture of ABZ and poloxamer 407 showed a tendency to decrease the development of murine cysts, causing damage to the germinal layer. In the clinical efficacy study, the ABZ:P407 SDs produced a significant decrease in the weight of murine cysts. In addition, the SDs produced extensive damage to the germinal layer. The increase in the efficacy of ABZ could be due to the improvement of water solubility and wettability of the drug due to the surfactant nature of poloxamer 407. In conclusion, this study is the basis for further research. This pharmacotechnical strategy might in the future offer novel treatment alternatives for human alveolar echinococcosis.

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Zagorulko, E. Yu, e A. S. Karavaeva. "APPROACHES TO THE SELECTION OF EXCIPIENTS FOR DENTAL GEL WITH CETYLPYRIDINIUM CHLORIDE". Pharmacy & Pharmacology 9, n. 1 (23 giugno 2021): 54–63. http://dx.doi.org/10.19163/2307-9266-2021-9-1-54-63.

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Abstract (sommario):

The aim of the study was to determine the excipients influence on the characteristics of gels with cetylpyridinium chloride and to select the dental gel formulation gelation agents promising for the development of dental gel compositions. Hereby, the properties of the active pharmaceutical ingredient, characteristics of the specific gelation agents, as well as their influence on stability, biopharmaceutical and application properties of gels, were taken into account. Materials and methods. In this study, polymers with various gelation mechanisms were considered. Their compatibility with cetylpyridinium chloride as well as storing kinetic and colloid kinds of stability, pH of aqueous solutions, spreadability and textural properties, a penetration ability by the agar diffusion method, an osmotic activity and rheological properties of the gels, were examined. For a complex evaluation of gel compositions study results, a desirability function was used.Results. Stable homogenous dental gels with cetylpyridinium chloride can be obtained by using 25% poloxamer 407 and 5.0% high molecular weight chitosan as the basis.The addition of poloxamer 188 to high molecular weight chitosan gels can produce stable systems with improved textural characteristics as well as increase their osmotic activity. Agar and low molecular weight chitosan addition significantly decrease, whereas poloxamer188 and various molecular weight polyethyleneglycol increase the osmotic activity of 25 % poloxamer 407 gels which are also characterized by a high penetration ability.Conclusion. A complex evaluation of biopharmaceutical, physicochemical and application properties of the gels made it possible to establish that combinations of poloxamer 407 with polyvinylpyrrolidone, agar, and low molecular weight chitosan, can be recommended as a base for a dental gel with cetylpyridinium chloride.

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Hom, David B., Khawar Medhi, Steven K. Juhn, Girma Assefa e Thomas P. Johnston. "Vascular Effects of Sustained-Release Fibroblast Growth Factors". Annals of Otology, Rhinology & Laryngology 105, n. 2 (febbraio 1996): 109–16. http://dx.doi.org/10.1177/000348949610500205.

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Abstract (sommario):

Since the half-life of most angiogenic growth factors is several hours or less, sustained-release delivery would be optimal for their future clinical use. Two fibroblast growth factors, basic fibroblast growth factor (bFGF) and endothelial cell growth factor (ECGF), were delivered in two sustained-released modalities (poloxamer 407 and a gelatin sponge [Gelfoam]) to attempt to increase soft tissue vascularity. In vitro bioactivity of ECGF-poloxamer formulations was also tested on endothelial cell cultures. Among vascular-compromised skin flaps in rabbits, ECGF-poloxamer (N = 26), bFGF-poloxamer (N = 5), ECGF-poloxamer (N = 9, irradiated), and bFGF-Gelfoam flaps (N = 22) did not demonstrate significant differences in viability and vascularity compared to controls (p > .05). Irradiation had a detrimental effect on both flap vascularity and viability (p = .02). Future efforts for sustained delivery of angiogenic proteins are critical in order to make them clinically useful in wound healing.

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An, Seong-Hyeon, Eunmi Ban, In-Young Chung, You-Hee Cho e Aeri Kim. "Antimicrobial Activities of Propolis in Poloxamer Based Topical Gels". Pharmaceutics 13, n. 12 (26 novembre 2021): 2021. http://dx.doi.org/10.3390/pharmaceutics13122021.

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Abstract (sommario):

Propolis contains a group of compounds with various activities. However, their low solubility is a drawback for the development of pharmaceutical formulations. In this study, poloxamers as a solubilizer and gelling agent were evaluated to develop a topical antimicrobial formulation of propolis. The effects of poloxamer type and concentration on the propolis solubility, release rate, and antimicrobial activities were investigated. Staphylococcus aureus (S. aureus) and Candida albicans (C. albicans) were the representative bacteria and fungi, respectively. At 5%, poloxamer 407 (P407) and poloxamer 188 (P188) enhanced the propolis solubility by 2.86 and 2.06 folds, respectively; at 10%, they were 2.81 and 2.59 folds, respectively. The micelle size in the P188 formulation increased in the presence of propolis, whereas there was no change in the P407 formulation. Release rates of propolis decreased with the P188 concentration increase, which was attributed to viscosity increase. Both P188 and P407 formulations showed antimicrobial activity against S. aureus in a time-kill kinetics assay. However, only the P188 formulation reduced the cell’s numbers significantly against C. albicans, compared to the control. We speculate that P188 mixed micelles were more effective in releasing free active compounds to exhibit anti-microbial activity compared to the P407 micelles encapsulating the hydrophobic compounds in their cores. Propolis in P188 formulation is proposed as a potential topical antimicrobial agent based on its activity against both S. aureus and C. albicans.

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Mahmoud, Nouf N., Haneen Qabooq, Shrouq Alsotari, Ola A. Tarawneh, Nour H. Aboalhaija, Sawsan Shraim, Alaaldin M. Alkilany, Enam A. Khalil e Rana Abu-Dahab. "Quercetin-gold nanorods incorporated into nanofibers: development, optimization and cytotoxicity". RSC Advances 11, n. 33 (2021): 19956–66. http://dx.doi.org/10.1039/d1ra02004h.

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44

Chen, Jianping, Rong Zhou, Lin Li, Bing Li, Xia Zhang e Jianyu Su. "Mechanical, Rheological and Release Behaviors of a Poloxamer 407/ Poloxamer 188/Carbopol 940 Thermosensitive Composite Hydrogel". Molecules 18, n. 10 (8 ottobre 2013): 12415–25. http://dx.doi.org/10.3390/molecules181012415.

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45

Urbán-Morlán, Z., R. Castro-Ríos, A. Chávez-Montes, L. M. Melgoza-Contreras, E. Piñón-Segundo, A. Ganem-Quintanar e D. Quintanar-Guerrero. "Determination of poloxamer 188 and poloxamer 407 using high-performance thin-layer chromatography in pharmaceutical formulations". Journal of Pharmaceutical and Biomedical Analysis 46, n. 4 (marzo 2008): 799–803. http://dx.doi.org/10.1016/j.jpba.2007.11.027.

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46

Dewan, Mitali, Koushik Dutta, Dipak Rana, Arijita Basu, Amartya Bhattacharya, Arghya Adhikary e Dipankar Chattopadhyay. "Effect of tamarind seed polysaccharide on thermogelation property and drug release profile of poloxamer 407-based ophthalmic formulation". New Journal of Chemistry 44, n. 36 (2020): 15708–15. http://dx.doi.org/10.1039/d0nj02767g.

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Abstract (sommario):

Herein, the potential impact of tamarind seed polysaccharide (TSP) on the gelation nature and in vitro release of a particular drug, pilocarpine hydrochloride, from different poloxamer 407-based ophthalmic formulations were evaluated.

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47

Kurniawansyah, Insan Sunan, Norisca Aliza Putriana, Agung Fitri Kusuma e Tan Mei Lee. "The Effectiveness of Chloramphenicol In-Situ Opthalmic Gel with Base Poloxamer 407 and HPMC Against Staphylococcus Aureus Atcc 29213 And Pseudomonas Aeruginosa Atcc 27853". International Journal of Drug Delivery Technology 9, n. 01 (9 gennaio 2019): 76–82. http://dx.doi.org/10.25258/ijddt.9.1.12.

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Abstract (sommario):

Introduction: In-situ gel is a simple liquid transparent polymer solution under storage conditions, but turns into a viscoelastic gel after entering the eye due to the phase transition properties of the polymer that increase the residence time in ocular organ and bioavailability, enabling the delivery of reproducible doses and improving patient compliance. The aim of the present study was to formulate and evaluate the antibacterial effectivity of chloramphenicol in-situ ophthalmic gel with base poloxamer 407 and HPMC base against Staphylococcus aureus and Pseudomonas aeruginosa. Material and Methods: The optimization of ophthalmic gel preparation by the factorial design method has been carried out in order to know the best formula of all the formulas employed with 0.5% chloramphenicol active substance, wherein each formula was obtained from high concentration and low concentration of each base. Results: The measurement of the antibacterial effectivity against Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 27853 by oneway ANOVA analysis showed that formula with base poloxamer 407 5% (F1) gave the best result. F1 has a dilute consistency, clear and stable during 28 days storage time when effectiveness test performed. Conclusions: Chloramphenicol in-situ gel with base poloxamer 407 and HPMC were effective against Staphylococcus aureus ATCC 29213 with intermediate to sensitive category, and Pseudomonas aeruginosa ATCC 27853 with sensitive category in accordance to the requirements of the Clinical and Laboratory Standards Institute (CLSI).

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48

Bin Jardan, Yousef A., Abdul Ahad, Mohammad Raish, Ajaz Ahmad, Mohd Aftab Alam, Abdullah M. Al-Mohizea e Fahad I. Al-Jenoobi. "Assessment of glibenclamide pharmacokinetics in poloxamer 407-induced hyperlipidemic rats". Saudi Pharmaceutical Journal 29, n. 7 (luglio 2021): 719–23. http://dx.doi.org/10.1016/j.jsps.2021.05.002.

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49

Peng, Xueying, Zeqin Lian, Xiao-Yuan Dai Perrard, Yunjie Xiao, Jing Ni, Veronica O’Brien, Henry Dong, Henry J. Pownall, Christie M. Ballantyne e Huaizhu Wu. "Poloxamer 407 Induces Hypertriglyceridemia but Decreases Atherosclerosis in Ldlr–/– Mice". Cells 11, n. 11 (30 maggio 2022): 1795. http://dx.doi.org/10.3390/cells11111795.

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Abstract (sommario):

Background: Hypertriglyceridemia (HTG) increases the risk for atherosclerotic cardiovascular disease, but underlying mechanisms are incompletely understood. Circulating monocytes play an important role in atherogenesis by infiltrating arterial walls, where they differentiate into macrophages. We tested the hypothesis that HTG is mechanistically linked to atherogenesis by altering the monocyte phenotype and infiltration into atherosclerotic lesions in a model of diet-induced atherogenesis in Ldlr–/– mice. Methods: HTG was induced in male Ldlr–/– mice, fed a Western, high-fat high-cholesterol diet, by daily injection of poloxamer 407 (P407), a lipoprotein lipase inhibitor, for seven weeks. Atherosclerosis, monocyte phenotypes, and monocyte migration into atherosclerotic lesions were determined by well-validated methods. Results: Compared with the saline control, P407 injection in Ldlr–/– mice rapidly induced profound and persistent HTG, modestly elevated plasma cholesterol levels, and increased levels of triglyceride and cholesterol carried in very-low-density lipoprotein and low-density lipoprotein. Unexpectedly, mice receiving P407 versus saline control showed less atherosclerosis. Following induction of HTG by P407, CD36+ (also CD11c+), but not CD36– (CD11c–), monocytes showed early increases in lipid accumulation, but the number of CD36+ (not CD36–) monocytes was dramatically decreased afterwards in the circulation until the end of the test. Concurrently, CD36+ (CD11c+) monocyte migration into atherosclerotic lesions was also reduced in mice receiving P407 versus controls. Conclusions: P407 induced severe HTG, but reduced atherosclerosis, in Ldlr–/– mice, possibly because of profound reductions of circulating CD36+ (CD11c+) monocytes, leading to decreased monocyte migration into atherosclerotic lesions.

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Kim, Mia, Tae-Woon Kim, Chang-Ju Kim, Mal-Soon Shin, Minha Hong, Hye-Sang Park e Sang-Seo Park. "Berberine Ameliorates Brain Inflammation in Poloxamer 407-Induced Hyperlipidemic Rats". International Neurourology Journal 23, Suppl 2 (30 novembre 2019): S102–110. http://dx.doi.org/10.5213/inj.1938216.108.

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