Letteratura scientifica selezionata sul tema "Plastifiants – Analyse"
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Articoli di riviste sul tema "Plastifiants – Analyse":
Tanoren, Bukem, Gurcan Albeniz, Mufide Aydogan Ahbab, Leyla Turker Sener, Işıl Albeniz, Fatma Ates Alkan, Nural Pastaci Ozsobaci, Berzem Selcuk e Mehmet Burcin Unlu. "Examination of Impact of Di(2-ethylhexyl) Phthalate and Dibutyl Phthalate on Rat Internal Organs by Scanning Acoustic Microscopy and Inductively Coupled Plasma Optical Emission Spectroscopy". Medical Science and Discovery 8, n. 4 (25 aprile 2021): 275–82. http://dx.doi.org/10.36472/msd.v8i4.534.
Tesi sul tema "Plastifiants – Analyse":
Descat, Amandine. "Développements de méthodes d'analyse des plastifiants de type phtalates et des acides biliaires dans des matrices biologiques : applications dans différents contextes physiopathologiques". Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS054.
This thesis has two main focuses:1/ Plasticizers, including phthalates, have been identified as category 1b carcinogenic, mutagenic and reprotoxic (CMR) and as endocrine disruptors. Di-2-ethylhexyl phthalate (DEHP) is one of the most common plasticizers and is generally associated with polyvinyl chloride (PVC) in medical devices. As DEHP is not covalently bound to PVC, it can easily migrate into lipophilic matrices and then reach the bloodstream. It is metabolized by the liver into mono-2-ethylhexyl phthalate (MEHP), which is just as toxic. In recent years, alternative plasticizers to DEHP have been developed, notably di-2-ethylhexyl terephthalate (DEHT), which is metabolized in vivo to mono-2-ethylhexyl terephthalate (MEHT).The first part of this thesis involved developing methods for measuring plasticizers and their metabolites in various biological matrices, such as plasma. Two LC-MS/MS methods were developed for the determination of DEHP and MEHP as well as DEHT metabolites. As the ionization in mass spectrometry of DEHT is very low, a LC-UV method was developed to quantify this terephthalate. These methods have made it possible to estimate the release of DEHP and DEHT from blood bags and to measure their primary metabolites in blood products.2/ Bile acids (BA) are a large family of steroids made up of numerous species. They are synthesized in the liver and intestine and represent the main route of cholesterol catabolism. 7a-hydroxy-4-cholesten-3-one (C4) is the precursor of BA. BA play an essential role in lipid absorption but also in cell signaling, as they are ligands for the nuclear receptor 'Farnesoid X receptor' (FXR) and/or the G protein-coupled membrane receptor, TGR5. These receptors, and hence their ligands, are involved in glucose homeostasis, lipid homeostasis and energy expenditure. Any modulation of the BA profile can therefore lead to changes in metabolic homeostasis. The second part of this thesis involved developing two LC-MS/MS assay methods for 31 BA species and C4 in different biological matrices, including plasma. A specific method for the determination of recently described BA derived from LCA in caecal contents is currently being optimized. These methods have made it possible to analyze variations in the BA profile in various cardiometabolic disease contexts (obesity, insulin resistance, type 2 diabetes, NAFLD).In conclusion, the analytical methods developed for quantifying plasticizers and BA have been validated and applied in preclinical and clinical studies. Interestingly, data from the literature and preliminary transient transfection assays have shown that phthalates and their metabolites modulate the activity of the peroxisome proliferator-activated receptor alpha (PPARa), a key regulator of metabolic homeostasis and expression of CYP7A1 (a major enzyme in hepatic BA synthesis). The analytical tools developed in this thesis open up original perspectives for studying the effects of phthalates on metabolic homeostasis via the regulation of BA metabolism. All of this work has made it possible to link analytical developments and applications in the field of biology and health
Yang, QiaoWen. "Systèmes polymériques à base de dispersion aqueuse administrés par voie orale pour la libération contrôlée du principe actif". Lille 2, 2009. http://www.theses.fr/2009LIL2S045.
Soomro, Munawar Hussain. "Health effects of endocrine disruptors during pregnancy and childhood Exposure to heavy metals during pregnancy related to gestational diabetes mellitus in diabetes-free mothers Prenatal exposure to phthalates and the development of eczema phenotypes in male children: Results from the EDEN mother-child Cohort study". Thesis, Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=http://theses-intra.upmc.fr/modules/resources/download/theses/2019SORUS243.pdf.
All humans are exposed to chemicals in everyday life, from food, indoor environment, cosmetics and other products that surround us at home and at work. Endocrine disruptors (EDCs) are man-made compounds that can bind to cell receptors and mimic or block the functions of natural hormones potentially resulting in adverse health effects. In recent years, hypotheses have been put forward that EDCs may contribute also to the development of allergic and respiratory diseases. In addition, it is likely that EDCs could act already during pregnancy by causing gestational diabetes mellitus and pregnancy induced hypertension, which may also trigger to develop hypertension and diabetes mellitus later in life. This dissertation provides evidence that maternal exposure to phthalates and heavy metals (Lead, Cadmium and Manganese) during pregnancy may be associated with gestational diabetes mellitus, pregnancy induced hypertension and later eczema/atopic dermatitis in children. We used ongoing French EDEN-mother child cohort data for our three studies. Our results add new suggestive evidence on the relationship between EDCs (phthalates and heavy metals we studied) and maternal and children health, that prenatal exposure to certain phthalates and heavy toxic metals may play a role in the development of gestational diabetes mellitus and pregnancy induced hypertension during pregnancy and later eczema in early childhood. Future research focusing on larger populations and addressing multiple exposures assessed prenatally and postnatally are required to provide more evidence on possible contributions of emerging pollutants to study the role of phthalates and heavy metals
Blachier, Christian. "Analyse des interactions entre diverses argiles et des polymères spécifiques, en milieu cimentaire, en présence de superplastifiant". Thesis, Vandoeuvre-les-Nancy, INPL, 2009. http://www.theses.fr/2009INPL034N.
Clay minerals which can be found in granular materials strongly influence the rheological properties of fresh concrete. Due to the recent technical evolution of concrete, the understanding of the effect of clays in such systems takes on a significant industrial interest. This study was divided into two part, the first one dealing with the adsorption mechanisms of two polymers onto clay surfaces: a superplasticizer (PCP) and a polycation (F25). IR and SAXS-WAXS analysis together with adsorption measurment revealed that superplasticizer are adsorbed by clays and that the used of polycation inhibites clays-PCP interactions. The adsorption process of F25 onto clays by cationic exchange explains the preferential adsorption of cationic compounds rather than PCP and the restructuration of clay particles at the nano and micronic scale during the adsorption. In a second part, the rheological study of granular suspensions revealed a strong effect of clay particles on the flow behaviors of such systems. The rheological study of pure clay suspensions allowed the modelisation of the effect of clays on granular suspensions using excluded volume. In this case, the anistropic features of clays particles characterized by various technics (TEM, SAXS-WAXS) explains water retention properties of such nanometric minerals
Echcherki, Thami. "Mise au point d'électrodes a membranes polymères contenant des ionophores sélectifs aux ions K, Na et Li pour le dosage de ces cations dans les milieux biologiques (analyses cliniques), et la détermination des énergies libres de transfert de l'eau dans les mélanges de solvants hydro-organiques". Nancy 1, 1995. http://www.theses.fr/1995NAN10151.