Bibliografie tematiche / Picropodophylline

Letteratura scientifica selezionata sul tema "Picropodophylline"

Autore: Grafiati

Pubblicato: 22 giugno 2024

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Articoli di riviste sul tema "Picropodophylline":

Roulland, Emmanuel, Emmanuel Bertounesque, Christiane Huel e Claude Monneret. "Synthesis of picropodophyllin homolactone". Tetrahedron Letters 41, n. 35 (agosto 2000): 6769–73. http://dx.doi.org/10.1016/s0040-4039(00)01136-9.

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Roulland, Emmanuel, Emmanuel Bertounesque, Christiane Huel e Claude Monneret. "ChemInform Abstract: Synthesis of Picropodophyllin Homolactone." ChemInform 31, n. 45 (7 novembre 2000): no. http://dx.doi.org/10.1002/chin.200045231.

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Wen, Pu Hong. "Kinetic Investigation of Thermal Decomposition Reactions of Podophyllic Acid and Picropodophyllic Acid". Advanced Materials Research 391-392 (dicembre 2011): 1230–34. http://dx.doi.org/10.4028/www.scientific.net/amr.391-392.1230.

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Abstract (sommario):

The thermal behavior and thermal decomposition kinetic parameters of podophyllic acid and picropodophyllic acid in a temperature-programmed mode have been investigated by means of DSC and TG-DTG. The kinetic model functions in differential and integral forms of the thermal decomposition reactions mentioned above for leading stage were established. The kinetic parameters of the apparent activation energy Ea and per-exponential factor A were obtained from analysis of the TG-DTG curves by integral and differential methods. The most probable kinetic model function of the decomposition reaction in differential form was 2/3•α-1/2 for podophyllic acid and 1/2• (1-α)-1 for picropodophyllic acid. The values of Ea indicated that the reactivity of picropodophyllic acid was highter than that of podophyllic acid in the thermal decomposition reaction. The values of the entropy of activation ΔS≠, enthalpy of activation ΔH≠ and free energy of activation ΔG≠ of the reactions were estimated.

Guo, Hong Zhu, De An Guo, Xue Yan Fei, Ya Jun Cui e Jun Hua Zheng. "Biotransformation of Podophyllotoxin to Picropodophyllin by Microbes". Journal of Asian Natural Products Research 1, n. 2 (dicembre 1998): 99–102. http://dx.doi.org/10.1080/10286029808039850.

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Ohshima-Hosoyama, Sachiko, Tohru Hosoyama, Laura D. Nelon e Charles Keller. "IGF-1 receptor inhibition by picropodophyllin in medulloblastoma". Biochemical and Biophysical Research Communications 399, n. 4 (settembre 2010): 727–32. http://dx.doi.org/10.1016/j.bbrc.2010.08.009.

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Wu, Qi, Ai-Ling Tian, Guido Kroemer e Oliver Kepp. "Autophagy induction by IGF1R inhibition with picropodophyllin and linsitinib". Autophagy 17, n. 8 (10 giugno 2021): 2046–47. http://dx.doi.org/10.1080/15548627.2021.1936934.

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Berkowitz, David B., Sungjo Choi e Jun-Ho Maeng. "Enzyme-Assisted Asymmetric Total Synthesis of (−)-Podophyllotoxin and (−)-Picropodophyllin". Journal of Organic Chemistry 65, n. 3 (febbraio 2000): 847–60. http://dx.doi.org/10.1021/jo991582+.

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Pohmakotr, Manat, Taweechote Komutkul, Patoomratana Tuchinda, Samrarn Prabpai, Palangpon Kongsaeree e Vichai Reutrakul. "Syntheses of (±)-thuriferic acid ethyl ester, its analogues and (±)-picropodophyllone". Tetrahedron 61, n. 22 (maggio 2005): 5311–21. http://dx.doi.org/10.1016/j.tet.2005.03.069.

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Pullin, Robert D. C., Jonathan D. Sellars e Patrick G. Steel. "Silenes in organic synthesis: a concise synthesis of (±)-epi-picropodophyllin". Organic & Biomolecular Chemistry 5, n. 19 (2007): 3201. http://dx.doi.org/10.1039/b710370k.

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Colón, Eugenia, Farasat Zaman, Magnus Axelson, Olle Larsson, Christine Carlsson-Skwirut, Konstantin V. Svechnikov e Olle Söder. "Insulin-Like Growth Factor-I Is an Important Antiapoptotic Factor for Rat Leydig Cells during Postnatal Development". Endocrinology 148, n. 1 (1 gennaio 2007): 128–39. http://dx.doi.org/10.1210/en.2006-0835.

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Abstract (sommario):

The present investigation examines the influence of IGF-I and the role of IGF-I receptor (IGF-IR) in the apoptosis/survival of Leydig cells. Immunohistochemical analysis of the rat testis at different ages revealed that the level of the phosphorylated IGF-IR increases from birth to d 20 of postnatal life, remaining high in the adult testis. Western blotting revealed that this level is higher in Leydig cells isolated from 40-d-old than from 10- or 60-d-old rats. Application of the terminal deoxyribonucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling assay revealed that IGF-I decreases the level of apoptosis in Leydig cells at all stages of development, and the selective inhibitor of IGF-IR, picropodophyllin, blocks this antiapoptotic effect. The mechanism underlying the antiapoptotic action of IGF-I involves the phosphatidylinositol 3-kinase/Akt pathway, and in immature Leydig cells, this growth factor enhances the expression of Bcl-2 and cellular inhibitor of apoptosis proteins 2, while preventing activation of caspase-3 by cleavage. Furthermore, IGF-II and high concentrations of insulin also evoke phosphorylation of IGF-IR and, like IGF-I, enhance the expression of the steroidogenic acute regulatory protein by Leydig cells. Inhibition of IGF-IR by picropodophyllin decreases the survival of Leydig cells, both in the presence and absence of IGF-I, demonstrating that signaling via the IGF-IR plays an important role in Leydig cell survival.

Più fonti

Tesi sul tema "Picropodophylline":

Zhao, Rathje Li-Sophie. "Tropomyosin in Normal and Malignant Cells and the Action of Picropodophyllin on the Microfilament and Microtubule Systems". Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-27767.

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Cell motility is a fundamental process, enabling cells to migrate, for instance during embryogenesis, tissue repair and defense. Force is generated by two protein systems, which also participate in cell proliferation, control macromolecular and organelle distribution and determine the fine structure of the cell interior. The major components of these are actin and tubulin, respectively, and they are referred to as the microfilament and the microtubule systems. This thesis focuses on tropomyosin, one of many microfilament associated proteins coupled to actin dynamics and organization and expressed in several isoform variants. Altered distribution and isoform expression of tropomyosin are signatures of malignant cells and are dealt with in the current thesis. The presence of tropomyosin isoforms in protruding lamellipodia of migrating cells is demonstrated, and a method to fractionate tropomyosin depending on its organization in an easily extractable, and a more tightly bound cytoplasmic form is presented. Analysis of the loosely associated tropomyosin fraction by gel filtration chromatography revealed that most of the tropomyosins in this fraction exist in a multimeric form. It was also observed that the distribution of tropomyosin varied between non-transformed and transformed cells with most of the isoforms enriched in the loosely bound fraction in the latter category of cells. Possibly this reflects the extensive reorganization of the microfilament system observed in cancer cells and which, depending on the context, can be normalized by introduction of certain tropomyosin isoforms. Many anti-cancer drugs target the microtubule system, inhibit cell division and promote apoptosis. Here it is shown that picropodophyllin, which has promising anticancer properties has a destabilizing effect on microtubules and via the microfilament system causes cells to detach from their substratum. Furthermore, picropodophyllin interferes with stimulation of the insulin-like growth factor receptor, which is involved in growth stimulation, differentiation and survival and whose expression is up-regulated in cancer cells.

Larsson, Patrik. "Inhibiting the IGF-1 receptor with the cyclolignan Picropodophyllin: an in vitro study of ovulation, implantation and receptivity in a mouse model". Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-89109.

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Picropodophyllin (PPP) is an analogue of the anti tumour lignan podophyllotoxin with the unique ability to selectively inhibit the receptor of Insulin like growth factor 1(IGF-1). IGF-1 is believed to play an important part in development of the endometrium facing implantation. With PPP treated mice, studies can be made to measure gene expression from tissue of both treated and untreated mice to compare the role of IGF-1 regarding ovulation, implantation and receptivity. The aim of this study was to analyze gene expression of some steroid hormone receptors and cytokines in ovaries from mice treated with PPP. In this study, seven mice were treated with PPP at different times and tissue was collected. PCR-primers for cDNA sequences of estrogene receptor α, estrogene receptor β, progesterone receptor A, progesterone receptor B, growth hormone receptor, interleukin 1 α, interleukin 1 β, tumour necrosis factor α and androgen receptor were used. Real Time PCR was run with the samples and gene expression was measured. The results of this study showed that the inhibition of IGF-1 receptor interacted with IGF-1 which lead to altered levels of estrogene receptor alpha, progesterone receptor, growth hormone receptor and androgen receptor that can decrease ovulation. The results also showed the differences in gene products between treated and untreated samples, suggesting that IGF-1 plays an important role regarding ovulation.

Studier med hjälp av den selektiva insulinlika tillväxtfaktor 1 receptorn (IGF-1R) antagonisten; picropodof?phyllin (PPP), hur samspelet mellan livmoderslemhinnan och implantationsprocessen, samt hur ovulationen påverkas av insulinlika tillväxtfaktorn 1 (IGF-1) kan nu utföras. IGF-1 tros ha en viktig roll för den reproduktiva processen, där den påverkar ovulation, implantation och embryoutveckling. IGF-familjen består av tre ligander; insulin, IGF-1 och IGF-2. IGF transporteras bundet till bindarprotein (IGFBP). Medlemmarna i IGF receptorfamiljen kan binda IGF-1, IGF-2 och insulin fast med olika affinitet. PPP som är en cykloligan, är en analog från podofyllotoxin och fungerar som en syntetisk IGF-1 receptorantagonist, som selektivt inhiberar receptorns aktivitet. PPP tros även kunna nedreglera genexpression av receptorn. Tre tidigare projektarbeten har utförts på vävnader från möss injicerade med PPP. Tyngdpunkterna i dessa arbeten har legat på immunhistokemiska studier av IGF-1 i reproduktionsorgan från möss, uttryck av IGF-1, dess receptor och bindarprotein 1 i ovarier och uterus efter behandling med PPP. I denna studie användes vävnad samt cDNA från sju möss behandlade med PPP, i olika stadier av reproduktionen samt även icke behandlade möss. Studiens syfte var att med sanntids-PCR jämföra genuttryck från östrogenreceptor α och β, progesteronreceptor A och B, tillväxthormonreceptor, Interleukin 1 α och β, ’tumor necrosis’ faktor α samt androgenreceptor i vävnad från PPP-behandlade och obehandlade möss och genom de erhållna resultaten från ovarievävnaden utläsa effekten på ovulationen och från uterusvävnaden effekten på implantation och receptivitet. Studieresultaten visade att IGF-1s frånvaro gav förändrade nivåer av genprodukter, som medförde minskad ovulationen. Studien visade att IGF-1s roll vid ovulationen var väsentlig.

Delforoush, Maryam. "Potential New Drugs in Lymphoma". Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280546.

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Lymphomas are malignant tumours arising from cells in the lymphatic system. They are classified as B-cell lymphomas, T-cell lymphomas and Hodgkin lymphoma (HL). Of the B-cell lymphomas, one of the most common is diffuse large B-cell lymphoma (DLBCL). Many patients with lymphomas can be successfully treated however patients who relapse or are refractory have a poor prognosis, warranting further investigations to identify potential targets and develop novel drugs. Picropodophyllin (PPP), a potent and selective inhibitor of IGF-1R, inhibits malignant cell growth with low or no toxicity on normal cells in preclinical models. In paper I, we investigated the potential benefits of using PPP against DLBCL and found that the anti-tumor effects of PPP might possibly be explained by IGF-1R-unrelated mechanism(s). However, the inhibitory effects of PPP on lymphoma cells together with its low toxicity in vivo makes it a promising drug candidate for treatment. Melflufen, a derivative of melphalan, is currently being evaluated in a clinical phase I/II trial in relapsed or refractory multiple myeloma. In paper II, we confirmed previous reports of superior potency of melflufen over melphalan. Being active in cell lines and primary cultures of lymphoma cells as well as in a xenograft model in mice, melflufen considered being a candidate for further evaluation in treatment. bAP-15, a novel inhibitor of proteasome activity, inhibits ubiquitin specific peptidase 14 (USP14) and ubiquitin carboxyl-terminal hydrolase L5 (UCHL5). In paper III, we investigated the activity of b-AP15 in DLBCL and HL cell lines and compared the results to standard drugs used in treatment. Results showed inhibition of the proteasome and growth inhibition/cytotoxicity with IC50-values in the micromolar range. Treatment failure and lack of clinical benefit of proteasome inhibitors like bortezomib in DLBCL patients inspired us investigating for possible new targets, with major focus on proteasome inhibitors in DLBCL. In paper IV, we suggested that UCHL5 and/or USP14, as new targets for proteasome inhibitors in DLBCL, be further evaluated. The findings in this thesis suggest that PPP, Melflufen and b-AP15 are potential candidates for clinical drug development and UCHL5 and/or USP14 are new potential targets for proteasome inhibitors in DLBCL.

Atti di convegni sul tema "Picropodophylline":

Wong Te Fong, Anne-Christine LF, Chris Jones, John R. Griffiths, Martin O. Leach e Yuen-Li Chung. "Abstract 5640: Picropodophyllin downregulates p53 and increases the Warburg effect in pediatric glioblastoma cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5640.

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