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Letteratura scientifica selezionata sul tema "Phytochemical database"

Autore: Grafiati

Pubblicato: 31 ottobre 2024

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Articoli di riviste sul tema "Phytochemical database"

Kay, Colin, Alex Smirnov, Jessica Everhart, Ciara Conway, Harry Schulz, Zhaocong Yang, Jing Yang e Xiuxia Du. "The Metabolome of Food Knowledge Database: Development of a Nutrition Database to Support Precision Nutrition". Current Developments in Nutrition 6, Supplement_1 (giugno 2022): 1114. http://dx.doi.org/10.1093/cdn/nzac078.008.

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Abstract Objectives To develop a precision nutrition knowledge database, with the aim to provide individualized and actionable dietary recommendations to help prevent disease. However presently, dietary phytochemicals are poorly represented in current metabolomic databases. To address this gap, we are building a cloud-based knowledge database (KDB) named “The Metabolome of Food” (MetaboFood®) which focuses on phytochemical compositional, metabolite and pathway data. Methods MetaboFood® features P-MetDB®, a database in static tabular form, of nutritionally relevant phytochemicals and their metabolites derived from systematic literature reviews of 17 commonly consumed phytochemical-rich foods, matched to InChI key, physical and chemical properties (mass, formula) and database identifiers (i.e., PubChem ID, KEGG ID, SMILES etc.). To build MetaboFood®, information about metabolic pathways and diseases associated with these foods have been extracted from various pathway databases using APIs that these databases provide. Information can be searched in MetaboFood® and results are explored in a highly visual and interactive way, in the form of self-organizing maps, node-link diagrams, Sankey diagrams and other visual analytics techniques. Results MetaboFood® captures data on foods, their phytochemical compositions, human and microbial metabolites, and pathway and diseases linkages. Information in MetaboFood® facilitates both hypothesis generation and hypothesis testing relative to food and pathway analysis. Initial use of this database identifies significant interactions between polyphenol rich foods and numerous metabolic networks. Conclusions MetaboFood® builds on traditional food composition databases by integrating biochemical and disease pathway data with diet metabolites. A key to moving forward is building data richness, enabling greater connections between diet and health. Funding Sources Research reported in this abstract was supported by a NIEHS Human Health Exposure Analysis Resource (HHEAR) program grant under award number 1U2CES030857-01 and a NIH Nutrition for Precision Health (NPH) Metabolomics and Clinical Assay Center (MCAC) grant under the award number 1U24CA268153-01. CDK was also supported by the USDA National Institute of Food and Agriculture Hatch award (Kay-Colin; 1,011,757).

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Elkhattabi, Lamiae. "Data insights from a Moroccan phytochemical database (MPDB) derived from aromatic & medicinal plants". Bioinformation 19, n. 12 (31 dicembre 2023): 1217–24. http://dx.doi.org/10.6026/973206300191217.

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The geographical location of Morocco and the diversity of its topography ensure a high variability of climate conditions, ranging from humid to Saharan, and extending through subhumid, arid, and semi-arid stages. This variability offers a high floristic diversity, while the medical use of these phytochemicals has not been fully explored. Advanced computer-aided drug discovery utilizes chemical biology to accelerate the study of phytochemicals at the molecular level and discover novel therapeutic pathways. Currently, there is no online resource for phytochemicals in Morocco. Therefore, it is of interest to describe the Moroccan Phytochemicals Database (MPDB), accessible, featuring over 600 phytochemicals derived from journal articles and other reports. The web interface of the database, which is simple and easy to use, provides each phytochemical's reference, plant sources, 3D structures, and all related information. Furthermore, we provide direct links to commercially available analogs from Mcule. In addition, we provide the results of the first virtual screening against cardiovascular targets. We present these data to facilitate further exploration and exploitation of Morocco's rich phytochemical resources, and to contribute to the global understanding and application of these compounds in the medical and scientific communities.

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Ashfaq, Usman Ali, Arooj Mumtaz, Tahir ul Qamar e Tabeer Fatima. "MAPS Database: Medicinal plant Activities, Phytochemical and Structural Database". Bioinformation 9, n. 19 (6 dicembre 2013): 993–95. http://dx.doi.org/10.6026/97320630009993.

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Rathaur, Pooja, e Kaid Johar SR. "Metabolism and Pharmacokinetics of Phytochemicals in the Human Body". Current Drug Metabolism 20, n. 14 (25 febbraio 2020): 1085–102. http://dx.doi.org/10.2174/1389200221666200103090757.

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Background: Phytochemicals are obtained from various plants and used for the treatment of diseases as both traditional and modern medicines. Poor bioavailability of phytochemicals is a major concern in applying phytochemicals as a therapeutic agent. It is, therefore, necessary to understand the metabolism and pharmacokinetics of phytochemicals for its implication as a therapeutic agent. Methods: Articles on the metabolism of phytochemicals from the PubMed database. The articles were classified into the digestion, absorption, metabolism, excretion, toxicity, and bioavailability of phytochemicals and the effect of gut microbiota on the metabolism of phytochemicals. Results: The metabolism of each phytochemical is largely dependent on the individual's digestive ability, membrane transporters, metabolizing enzymes and gut microbiota. Further, the form of the phytochemical and genetic make-up of the individual greatly influences the metabolism of phytochemicals. Conclusion: The metabolism of phytochemicals is mostly depended on the form of phytochemicals and individualspecific variations in the metabolism of phytochemicals. Understanding the metabolism and pharmacokinetics of phytochemicals might help in applying plant-based medicines for the treatment of various diseases.

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Yasmine, Syafira, Neissya Nastiti Firmanto, Annisa Maya Sabrina e Siti Khaerunnisa. "MOLECULAR DOCKING OF CROCUS SATIVUS PHYTOCHEMICALS AGAINST INDUCIBLE NITRIC OXIDE SYNTHASE AND PHOSPHODIESTERASE-9 IN HEART FAILURE PRESERVED EJECTION FRACTION". Majalah Biomorfologi 33, n. 1 (10 gennaio 2023): 20–29. http://dx.doi.org/10.20473/mbiom.v33i1.2023.20-29.

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Highlights1. Heart failure preserved ejection fraction increases the mortality rate every year.2. Definitive therapy for HFpEF is not well identified.3. Crocus sativus phytochemical has anti-inflammatory and cardioprotective effects due to iNOS and PDE-9 inhibition. AbstractBackground: Heart failure preserved ejection fraction (HFpEF) is a complex disease associated with metabolic disease as a risk factor. A previous study found an association between iNOS and PDE-9 with inflammation and myocardial fibrosis in HFpEF. Objective: This study aimed to identify the potential phytochemicals of Crocus sativus (Saffron) that can inhibit protein iNOS and PDE-9 based on a molecular docking study. Material and Method: A total of fifty phytochemicals were obtained from Dr. Duke’s Phytochemical Database and IJAH IPB. Those phytochemicals were screened by using the PyRx application and followed with Lipinski’s Rule of Five screening by using SWISS Adme. Ten phytochemicals with lowest binding energy for each protein were docked and visually analyzed using Autodock 4.2 and BIOVIA Discovery Studio Visualizer 2016. Results: The best binding energy between protein-phytochemicals were -9.17 kcal/mol and -8.55 kcal/mol for iNOS and -9.17 kcal,/mol and -9.08 kcal/mol for PDE-9. Conclusion: Delphinidine and malvidin are the recommended inhibitors against iNOS and PDE-9 and must be investigated in further research.

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Rathnayake, Samith, e Samantha Weerasinghe. "Development of an Information System of Structures and Force Field Parameters of Chemical Compounds from Sri Lankan Flora". Combinatorial Chemistry & High Throughput Screening 21, n. 8 (17 dicembre 2018): 550–56. http://dx.doi.org/10.2174/1386207321666181010113533.

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Background: Sri Lanka offers a huge diversity of flora with a large proportion of those being endemic to the island. Both the endemic and native plants species serve as a rich bank of phytochemicals. Method: In this study, “Sri Lankan Flora” an online web-based information system of phytochemical compounds isolated from the flora of Sri Lanka was proposed. Results: The database contained 3D structures of those compounds, calculated quantitativestructure- activity relationship (QSAR) data and the GROMOS 54a7 force field parameters for each and every compound. The manually curated chemical structures, activities and force field parameters provide a possible direct avenue for computer-aided drug discovery. The present study is a continuing project with a wider goal of building up a database, not only for assisting the computeraided drug designing process, but also for other chemical applications, as the database includes structural, physical, chemical and dynamic properties of chemical compounds of the flora of Sri Lanka. The database is freely accessible at http://science.cmb.ac.lk/tools/slflora.

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Fitriani, Ika Nur, e Wiji Utami. "Potential Phytochemical Inhibitor from Allium cepa for the Medication of COVID-19 using In-Silico Approach". ALKIMIA : Jurnal Ilmu Kimia dan Terapan 4, n. 2 (1 aprile 2021): 80–87. http://dx.doi.org/10.19109/alkimia.v4i2.7459.

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Infection of extreme acute respiratory syndrome coronavirus 2 triggers Coronavirus disease 2019 (COVID-19). COVID-19 has adverse consequences on persons and is getting worse in all nations. The aim of this research is to investigate the development of in-silico approach of phytochemical inhibitor used to fight COVID-19 pathway inhibition. In medicinal plants, there are many phytochemicals, however the bioactive mechanism remains uncertain. In-silico experiments offer additional evidence to confirm the inhibition of medicinal plants. Molecular docking was used to evaluate phytoconstituents from Allium cepa as COVID-19 M-pro inhibitor, compared to remdesivir (standard drug). STITCH database used to predict the interaction network process of the most potential compound. The most potential compound was oleanolic acid. Oleanolic acid with a docking score of -9.20 kcal/mol was reported as anti-COVID-19 activity. This docking score was higher than remdesivir. Oleanolic acid interacted with GLU166, CYS44, HIS41, and THR25 via the hydrogen bond. From STITCH Database, oleanolic acid interact with CASP-9, XIAP, CASP-3 signalling pathway. Oleanolic acid from Allium cepa has been reported as a possible COVID-19 M-pro inhibitor and should be studied in future studies. The experiment indicates that phytochemical inhibitor can be helpful in the medication of COVID-19.

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Zarshenas, Mohammad M., e Liselotte Krenn. "Phytochemical and Pharmacological Aspects of Salvia mirzayanii Rech. f. & Esfand". Journal of Evidence-Based Complementary & Alternative Medicine 20, n. 1 (19 ottobre 2014): 65–72. http://dx.doi.org/10.1177/2156587214553938.

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Salvia mirzayanii Rech. f. & Esfand is an endemic herbaceous plant belonging to the Lamiaceae family. The plant grows in the center and south of Iran and is broadly used in folk medicine. This review focuses on phytochemical and pharmacological data of S mirzayanii. Databases such as PubMed, Scopus, Web of Science, Scientific Information Database (Iranian database involving English and Persian articles), and Google Scholar were searched for terms “ Salvia mirzayanii,” “Iranian sage,” “ Marv-e-Talkh,” and “ Moor-e-Talkh” in both Persian and English up to December 10, 2013. In line with the ethnopharmacological uses, antioxidant, immunomodulatory, anti-inflammatory, antimicrobial, and insecticidal activities of different preparations of S mirzayanii have been shown in recent studies. The antimicrobial activity against human pathogenic strains has mainly been attributed to the essential oil of S mirzayanii, which in numerous analyses has been investigated either in plants of different origin or prepared by differing extraction methods. Despite the studies on antioxidant or antimicrobial activities, profound research on the toxicity or clinical properties of the herb is missing.

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LİNGFA, Lali, Aravinda TİRUMALA e Srinivas ANKANAGARİ. "GC-MS profiling of anticancer and antimicrobial phytochemicals in the vegetative leaf, root, and stem of Withania somnifera (L.) Dunal". International Journal of Secondary Metabolite 11, n. 1 (15 dicembre 2023): 63–77. http://dx.doi.org/10.21448/ijsm.1256932.

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Withania somnifera has been used for a long time in traditional medicine. Its crude extract, dried powder, and purified metabolites from mature plants have shown promising therapeutic potential. To further investigate its potential, the detection of phytochemicals with anticancer and antimicrobial properties in the vegetative stage is essential. Hence, this study was done to identify phytochemical constituents using GC-MS analysis for anticancer and antimicrobial activities in the vegetative stage from methanolic extracts of stem, leaf, and root in W. somnifera. The air-dried plant parts were extracted with methanol at low pressure to concentrate using a rotary evaporator at 40°C. To identify phytochemicals, Shimadzu GCMSQP2010, Japan, was used with the NIST107.LIB database. The GC-MS identified 35 unique phytochemical peaks at the vegetative stage in W. somnifera. In leaves, the antibacterial phytochemicals included cyclotrisiloxane, hexamethyl, with a high abundance, and cyclohexasiloxane, dodecamethyl, with the least abundance. In roots, the phytochemicals 2,2-dimethoxybutane, with high abundance, and cathinone, with least abundance, were found to have antibacterial properties, whereas trans-2,3-epoxyoctane, with high abundance, and 2,2-dimethoxybutane, with least abundance, were found to have anticancer properties. In stem, the antibacterial phytoconstituents octasiloxane, 1,1,3,3,5,5,7,7,9,9,11,11,13,13,15,15-hexadecamethyl, and benzenemethanol, alpha.-(1-aminoethyl), were found to be the most abundant and least abundant, respectively, while arabinitol and pentaacetate had both anticancer and antibacterial activities. At the vegetative stage, GC-MS studies of stem, leaf, and root parts revealed the occurrence of potential phytochemicals for antibacterial and anticancer activities in W. somnifera.

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Fatima, Shehnaz, Payal Gupta, Shilpa Sharma, Ashish Sharma e Subhash M. Agarwal. "ADMET profiling of geographically diverse phytochemical using chemoinformatic tools". Future Medicinal Chemistry 12, n. 1 (gennaio 2020): 69–87. http://dx.doi.org/10.4155/fmc-2019-0206.

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Aim: Phytocompounds are important due to their uniqueness, however, only few reach the development phase due to their poor pharmacokinetics. Therefore, preassessing the absorption, distribution, metabolism, excretion and toxicity (ADMET) properties is essential in drug discovery. Methodology: Biologically diverse databases (Phytochemica, SerpentinaDB, SANCDB and NuBBEDB) covering the region of India, Brazil and South Africa were considered to predict the ADMET using chemoinformatic tools (Qikprop, pkCSM and DataWarrior). Results: Screening through each of pharmacokinetic criteria resulted in identification of 24 compounds that adhere to all the ADMET properties. Furthermore, assessment revealed that five have potent anticancer biological activity against cancer cell lines. Conclusion: We have established an open-access database (ADMET-BIS) to enable identification of promising molecules that follow ADMET properties and can be considered for drug development.

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Più fonti

Libri sul tema "Phytochemical database"

Duke, James A. Database of Phytochemical Constituents of Gras Herbs and Other Economic Plants. CRC-Press, 1992.

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Duke, James A. Database of Biologically Active Phytochemicals & Their Activity. CRC, 1992.

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Duke, James A. Database of Biologically Active Phytochemicals and Their Activity. Taylor & Francis Group, 2020.

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Duke, James A. DATABASE of BIOLOGICALLY ACTIVE PHYTOCHEMICALS and THEIR ACTIVITY. Taylor & Francis Group, 2020.

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Duke, James A. Database of Biologically Active Phytochemicals and Their Activity. Taylor & Francis Group, 2020.

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Duke, James A. Database of Biologically Active Phytochemicals and Their Activity. Taylor & Francis Group, 2020.

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Database of Biologically Active Phytochemicals and Their Activity. Taylor & Francis Group, 2020.

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Capitoli di libri sul tema "Phytochemical database"

Beckstrom-Sternberg, Stephen M. "Utility of the Phytochemeco Database". In Phytochemical Potential of Tropical Plants, 267–86. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4899-1783-6_11.

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Islam, Khushbu, Nirala Ramchiary e Ajay Kumar. "Databases Relevant to Phytochemicals and Genes That Govern Biosynthesis of the Phytochemicals". In Phytochemical Genomics, 361–77. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-5779-6_14.

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Joy, Christy, e Marria C. Cyriac. "Phytochemicals as Potential Drug Candidates for SARS Cov-2: An RDRp Based In-Silico Drug Designing". In Proceedings of the Conference BioSangam 2022: Emerging Trends in Biotechnology (BIOSANGAM 2022), 58–69. Dordrecht: Atlantis Press International BV, 2022. http://dx.doi.org/10.2991/978-94-6463-020-6_7.

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AbstractThe global pandemic that the world is currently witnessing, COVID-19, even with vaccines available, the test positivity rate (TPR) tends to remain highly threatening. This research focuses on identifying phytochemicals, previously known for their broad-spectrum antiviral properties which can be potential drug candidates for theSARS-CoV-2. A total of 225 phytocompounds (downloaded from PubChem database) are docked against targetprotein (downloaded from PDB database) of SARS-CoV-2using the POAP pipeline. The target protein is the RDRp complex. They are screened according to their binding affinity values and the filtered phytochemicals are then subjected to various analyses including ADME properties (preADMET, swissADME), bioactivity score, and molecular properties (molinspiration), drug-likeness (preADMET), lipophilicity, water solubility, and pharmacokinetics (swissADME). The receptor-ligand interactions and the amino acid positions are obtained using Discovery Studio Visualiser. Molecular dynamic simulation studies are performed to reveal key receptor-drug interactions that must be formed to achieve tight drug binding and also to predict stability. Out of the 225, 10 phytochemicals showed the best scores and more probability of drug action. Compounds that showed promising drug action potential include oriciacridone, corilagin, cinchophyllamine, sophaline D, amentoflavone, cryptomisrine, ginkgetin, hypericin, pseudojervine, dieckol, hinokiflavone, robustaflavone, solamargine. The research herein provides new possibilities for in vitro and in vivo analyses of the proposed ligands to develop new drugs againstSARS-CoV-2.

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López-Pérez, José Luis, Roberto Theron, Esther del Olmo, Beatriz Santos-Buitrago, José Francisco Adserias, Carlos Estévez, Carlos García Cuadrado, David Eguiluz López e Gustavo Santos-García. "NAPROC-13: A Carbon NMR Web Database for the Structural Elucidation of Natural Products and Food Phytochemicals". In Advances in Intelligent Systems and Computing, 9–19. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07581-5_2.

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Lans, Cheryl, e Tedje van Asseldonk. "Dr. Duke’s Phytochemical and Ethnobotanical Databases, a Cornerstone in the Validation of Ethnoveterinary Medicinal Plants, as Demonstrated by Data on Pets in British Columbia". In Medicinal and Aromatic Plants of the World, 219–46. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44930-8_10.

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Shagun, Shagun, e Shyam Kumar Masakapalli. "Phytochemical Databases and their Relevance to Phytotherapy". In Bioactive Phytochemicals from Himalayas: A Phytotherapeutic Approach, 128–56. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815123289123010013.

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Phytochemical databases are a rich source of information that supports phytotherapy research and the conservation of medicinally important plants. Collecting the knowledge of databases and their specific focus along with ways to use them efficiently will help the community. This chapter summarises the phytochemical databases available that support phytotherapy research and the conservation of medicinally important plants. Broadly, 56 databases that are classified into regionspecific, disease-specific, other common medicinal and phytochemical databases, and Himalayan-region-specific plant databases, have been summarised for ready reference in this book chapter. We also provide a typical workflow with examples to search the phytochemicals of selected Himalayan medicinal plants from existing Himalayan region-specific databases of Medicinal Plants. Finally, the need for urgently developing a comprehensive Himalayan-specific phytochemical database for phytotherapy is proposed.

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Sujana, K., A. V. Surendra, K. V. Kishore, SK Reehana e C. B. Himakalyani. "Phytochemical Analysis and Characterization of Ethanolic Extract of Pseuderanthemum Malabaricum Whole Plant". In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022), 735–48. Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00735.

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Ancient times onwards mankind is dependent on the plants and other natural resources for the new chemical molecules in search of beneficial phytochemicals for therapy. Present study was intended to find out such phytochemicals in the ethanolic extract of Pseuderanthemum malabaricum which may become useful molecules in pharmacological perspective. Shade dried whole plant of Pseuderanthemum malabaricum was powdered and extracted with ethanol using Soxhlet extractor. Preliminary phytochemical analysis of ethanolic extract showed the presence of steroids, terpenoids, saponins, coumarins, flavonoids, phenols and chalcones. Gas chromatography-Mass spectroscopy/Mass spectroscopy (GC-MS/MS) analysis was carried out for identification and characterization of phytoconstituents by comparing with the database of National Institute Standard and Technology. Around 10 different types of chemical entities with varying quantities were identified. Among them, 4H-Pyran-4-one-2, 3-dihydro-3, 5-dihydroxy-6-methyl-(DDMP), 2-Furancarboxaldehyde-5 (hydroxymethyl) - (5HMF), 1-(+)-ascorbic acid-2-6- dihexadecanoate possess antioxidant, and anticancer properties. This stydy, identification of different biologically active compounds in the Pseuderanthemum malabaricum ethanolic extract forms the basis for further biological and pharmacological studies.

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Ahmad, Nurul Izzah, Suraiami Mustar, Salina Abdul Rahman e Roshan Jahn Mohd Salim. "Tamarindus indica L. Its Phytochemicals and Health Related Issues". In Science of Spices and Culinary Herbs - Latest Laboratory, Pre-clinical, and Clinical Studies, 93–146. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815274370124060006.

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Tamarindus indica L. is a multifunctional plant native to Madagascar that may now be found in most tropical and subtropical climates from Africa through South Asia, northern Australia, Southeast Asia, and China. Almost every part of the tree is used in the food, chemical, pharmaceutical, or textile industries, as well as for fodder, wood, and fuel. It has been connected to a variety of therapeutic uses, including inflammation, diabetes, constipation, indigestion, flatulence, and more. The purpose of this chapter is to review research subjects on phytochemical elements in tamarind and their relationship to health that have recently been published in peer-reviewed journals. We gathered data from original peer-reviewed studies that focused on Tamarindus indica L., its phytochemicals, and health/medicinal-related issues. We used four NIH Library-registered databases to perform our literature search. We included open access research and review publications in English (2010 to 2021). A total of 124 articles were used to form the basis of the discussion. Among the phytochemical components found in tamarind stem bark aqueous extract were saponin, catechin, iristectorin A, proanthocyanidin B1, procyanidin tetramer, and procyanidin trimer (bergenin, catechin, iristectorin A, proanthocyanidin B1, procyanidin tetramer, and procyanidin trimer). The essential oil (limonene, linalool anthranilate, p-cymene), 3-eicosyne, cryptopinone, free and conjugated fatty acids (malic, tartaric, phthalic, palmitic, 10-octadecenoic, and nnonadecanoic), flavones (luteolin 7-o-glucoside, luteolin, apigenin, isorientin (caffeic acid) were most identified in tamarind leaf. Diphenyl-ether, longifolene, caryophyllene, and 6, 10, 14-trimethylpentadeca-5, 9, 13-trien-2-one were among the new chemicals discovered in the leaf extract. 2-furancarboxaldehyde, 2, 3-butanediol, and 2- furancarboxaldehyde, 5-methyl were the most common phytochemicals found in pulp extracts. These chemicals are known for their antioxidant properties, treatment of allergic rhinitis, anti-inflammatory and analgesic properties, antidiabetic and antibacterial activity, etc. Because this versatile plant has been widely utilised as herbal medicine, the findings of this review could be used as a database for future phytochemicals and clinical studies of this plant. Considering the plant's uses and benefits, it can be recommended as a valuable multifunctional medicinal plant for both animals and humans.

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O. Ochora, Douglas, Thrineshen Moodley e Rose Hayeshi. "Phytochemistry, Pharmacological Activities, and Drug Interactions of Pomegranate, Punica granatum L. (Punicaceae)". In Pomegranate - Biochemistry, Nutritional Benefits and Applications [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.1003779.

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Pomegranate (Punica granatum L.) is a Mediterranean plant that has been used in various countries for the treatment of various diseases in traditional medicine for many generations. These reported medicinal properties of pomegranate are mainly attributed to the presence of various phytochemical compounds in the plant. Scientific literature search was done in PubMed and Google Scholar databases. Full articles published in English for the last 25 years were selected. Pomegranate juice is the widely studied product of a plant. This is because of its wide medicinal and dietary use. Approximately 500 pure compounds have been isolated and characterized from different parts of the plant species. Phytochemically, the juice, seeds, flowers, and peels of P. granatum are the most studied parts of the plant. Major phytochemical compounds isolated from the plant include alkaloids, flavonoids, phenolics, tannins, sterols, and terpenes. Most of the compounds isolated from P. granatum belong to ellagitannins (punicalagins) and gallotannins. Medicinally, the use of different parts of pomegranate for the treatment of different types of cancer and cardiovascular diseases is the most widely reported in both preclinical and clinical researches. The herb/food-drug interactions of pomegranate juice with approved drugs have shown that pomegranate juice has the potential to inhibit some drugs, especially those metabolized by cytochrome CYP3A and CYP2C9. The current chapter gives a broad overview of the phytochemical, pharmacological, and herb/food-drug interactions of pomegranate.

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Fatima Roohi, Tamsheel, Syed Faizan, Dr K. L. Krishna e Dr Seema Mehdi. "ADVANCES IN UNDERSTANDING CELLULAR MECHANISMS OF CARDIOVASCULAR COMPLICATIONS AND RETINOPATHY IN DIABETES: THERAPEUTIC POTENTIAL OF PHYTOCHEMICALS". In Futuristic Trends in Medical Sciences Volume 3 Book 3, 101–24. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bdms3p5ch1.

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Comprehensive knowledge of the pathophysiology, aetiology, and clinical course of diabetes mellitus is paramount to prognosticating cardiovascular and ocular complications. This chapter investigates the mechanisms and processes governing the progressive development of cardiovascular complications and retinopathy in patients with diabetes. We also aimed to determine the diabetes prevention and management potential of multimodal treatments (including phytochemical methods). Thirty-four research articles were analysed to determine the pathophysiology, cellular mechanisms, and biomarkers associated with cardiovascular and ocular complications of diabetes. Data sources included PubMed Central, Web of Science, and JSTOR. Data extraction was guided by the advanced filters of the respective databases. Primary and secondary research articles with the latest evidence on the pathobiology and treatment of diabetic complications were extracted for this updated review. The predominant causes of diabetic retinopathy and diabetic macular edema include haemorrhage and retinal capillary aneurysms. Diabetes type, age at diagnosis, and race are independent predictors of the risk and incidence of non-proliferative and proliferative diabetic retinopathy (NPDR/PDR). In addition, 75% of diabetes-related deaths are attributed to cardiovascular complications including peripheral vascular disease, thromboembolism, stroke, nephropathy, coronary artery disease, and atherosclerosis. Training researchers and physicians on the therapeutic efficacy of phytochemical methods against NPDR/PDR and diabetes-related cardiovascular diseases is needed to increase their use in adjuvant treatments. In addition, comprehensive knowledge of the pathophysiology/cellular mechanisms of diabetes is paramount for improving treatment outcomes. Future studies should investigate the medicinal value of various plant extracts, including their phytochemicals, to transform the therapeutic landscape for diabetes management.

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Atti di convegni sul tema "Phytochemical database"

Senga, Kento, Kaci Ho, Jon-Paul Bingham e Marisa Wall. "Nutrient Content and Carotenoid Bioaccessibility of Underutilized Taro Varieties from Hawaii". In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/xxpa8618.

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Abstract (sommario):

Taro (Colocasia esculenta), a starchy root crop, is widely consumed across Asia and the Pacific and exists as different colored varieties in Hawai‘i. Although nutritional information exists for taro, there is a lack of variety-specific compositional data. In this study, the nutrient content (proximate and mineral via ICP-OES), phytochemical content (carotenoid via HPLC-PDA, total phenolic via Folin-Ciocalteau assay, and total monomeric anthocyanin via pH differential method), and carotenoid bioaccessibility (digestibility and micellarization efficiency via three-stage simulated digestion) were compared for three non-commercial taro, Mana Ulu, Pi‘iali‘i, and immature Pi‘iali‘i (Keiki) with one commercial variety, Maui Lehua. Nutrient and phytochemical contents differed across each taro cultivar based on their raw and cooked forms (P< 0.05). Beta-carotene and lutein were the primary carotenoids across each cultivar, with Mana Ulu containing the highest carotenoid concentration. Beta-carotene exhibited digestive stability of 45.8% and a micellarization efficiency of 13.6% from Mana Ulu samples. Total phenolic content was 83.52, 76.04, 75.44, and 66.86 mg/100 g FW and total anthocyanin content of 10.02, 9.33, 7.32, and 6.93 mg/100g FW for Maui Lehua, Mana Ulu, Pi‘iali‘i Keiki, and Pi‘iali‘i, respectively. Cooked taro had significant polyphenol losses with total phenolic contents of 20.55, 17.73, 22.61, 25.93 mg/100g FW, as well as total anthocyanin contents of 3.19, 2.16, 2.12, and 2.88 mg/100g FW for Maui Lehua, Mana Ulu, Pi‘iali‘i Keiki, and Pi‘iali‘i, respectively. These findings indicate unique nutritional and phytochemical profiles amongst underutilized taro varieties, which could be better leveraged to improve nutrition and health outcomes. Overall, expanding variety-specific compositional data is critical to ensure reliable database information to assess the nutritional adequacy of diets.

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Jacobtorweihen, J., e V. Spiegler. "Short Lecture 2 “The establishment of an analytical database of algal bromophenols and phytochemical characterization of the red alga Vertebrata lanosa”". In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1758883.

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Recario, Jazmine Mae, Geoffrey Solano e Angelyn Lao. "PlaPhy-SMD: A Database System of Plants and their Phytochemicals Integrated with Small-Molecule Drugs and their Condition and Gene Associations with Clustering and Product Ingredient Matching". In 2020 11th International Conference on Information, Intelligence, Systems and Applications (IISA). IEEE, 2020. http://dx.doi.org/10.1109/iisa50023.2020.9284382.

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