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1
Toorians, Arno W. F. T., Sharyn Kelleher, Louis J. Gooren, Mark Jimenez e David J. Handelsman. "Estimating the Contribution of the Prostate to Blood Dihydrotestosterone". Journal of Clinical Endocrinology & Metabolism 88, n. 11 (1 novembre 2003): 5207–11. http://dx.doi.org/10.1210/jc.2003-030521.
Testo completoAbstract (sommario):
Abstract The prostate strongly expresses type 2 5α-reductase, which avidly converts on entry most testosterone (T) to 5α-dihydrotestosterone (DHT). However, the quantitative contribution of the prostate to blood DHT is uncertain. We evaluated prostatic contribution to blood DHT by comparing the blood DHT concentrations in androgen-deficient patients with or without a prostate while they were receiving standard dose of T replacement. Androgen-deficient males (ADM) and female to male (F2M) transsexuals were studied in 2 centers, with both groups receiving either testosterone ester injections (250 mg mixed T esters) every 1 wk (Amsterdam) or 800 mg subdermal T implantation (Sydney). Among 39 Dutch patients, F2M (n = 21) were younger and smaller in physique than ADM (n = 18). One week (±1 d) after an injection, plasma DHT concentrations were 1.6 ± 0.2 (F2M) vs. 1.4 ± 0.2 (ADM) nmol/liter (P = 0.47), but the postinjection time interval to blood sampling was shorter in F2M (5.9 ± 0.4 vs. 7.2 ± 0.3 d; P = 0.01). Covariance adjustment for time since last injection, age, and physique did not change the lack of significant difference in postinjection plasma DHT concentration. The rapid and wide excursions in plasma T concentrations after an im T ester injection make the timing of blood sampling critical. To remove confounding by this variable, the experiment was repeated at a second site in similar patients, but using a depot T that achieves steady-state delivery for prolonged periods. Among 29 Australian patients, before and 1 month after subdermal implantation of 800 mg T, plasma DHT concentrations were not significantly different between groups [F2M, 1.1 ± 0.1 (n = 14); ADM, 1.3 ± 0.1 (n = 15); P = 0.28]. Correction for covariates, including age, height, weight, body surface area, and body mass index, did not influence the lack of significant difference between treated groups. As both modes of T administration yielded similar plasma DHT concentrations regardless of the presence of a prostate, this study indicates that the normal human prostate is not a major contributor to circulating blood DHT concentrations.
2
Baynard, Elsa, Kevin Cassou, Pierre Drobniak, Julien Demailly, Olivier Guilbaud, Adrien Kraych, Bruno Lucas et al. "Laserix : Une plate-forme pour le développement large spectre d’applications de la lumière intense". Photoniques, n. 118 (2023): 30–34. http://dx.doi.org/10.1051/photon/202311830.
Testo completoAbstract (sommario):
LASERIX est une plateforme de l’IJClab sur le campus de l’Université Paris Saclay. Le laser est une chaîne CPA de niveau 50 TW à 10 Hz. Des thématiques de recherche en rapport avec la physique des deux infinis sont menées en parallèle avec une vocation affirmée d’ouverture à la formation. Nous présentons un panorama sur les sources XUV de lumière structurée, l’accélération laser plasma et des études prospectives sur l’étude des propriétés du vide soumis à un champ électromagnétique ultra-intense.
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Eberhard, Yves, e Jacqueline Eterradossi. "Effort et trisomiques 21 : descriptif de quelques réponses métaboliques lors de l’activité physique". STAPS 11, n. 23 (1990): 57–65. http://dx.doi.org/10.3406/staps.1990.1195.
Testo completoAbstract (sommario):
Les objectifs de cette étude sont de connaître les possibilités d’adaptations à l’effort chez les Trisomiques 21 de manière à savoir si l’effort a chez eux des répercussions métaboliques favorables ou défavorables. Pour cela, 11 sujets (garçons et filles de 15 à 20 ans) trisomiques 21 (T21), en bonne santé, originaires de la région grenobloise ont participé à une expérimentation. Après une période de mise en condition physique et de familiarisation avec les techniques d’effort en laboratoire, un profil de réponses métaboliques a été estimé avant et après 2 exercices sur cycloergomètre : 1 Monogramme, les substrats, les catécholamines, les lipoprotéines du plasma ont été dosés avant et après 1 exercice maximal de courte durée et 1 exercice d’endurance de 40 minutes. De même un dosage de la superoxyde dismutase (SOD-1) dans les globules rouges a été réalisé en fin d’effort. Les résultats montrent : a) un lactate sanguin à l’exercice maximal peu augmenté, b) une lente mobilisation des AGL au début de l’exercice, c) un profil lipidique de repos soulignant un niveau de cholestérol HDL faible et un haut niveau de prébêta VLDL, d) un ajustement presque normal de ces profils lipidiques sous l’effet de l’activité d’endurance, (e) des différences dans les valeurs de SOD-1 entre les T21 sédentaires et les T21 entraînés. Ces résultats suggèrent que les adolescents T21 sont capables d’un certain niveau de performance dans l’exercice physique. Les modifications constatées à la suite d’un exercice de longue durée en faveur d’une normalisation du profil lipidique, engagent à vérifier si une activité physique régulièrement pratiquée permet d’obtenir une amélioration stable de leur bilan lipidique au repos.
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Maggiolo, R., M. Echim, J. De Keyser, D. Fontaine, C. Jacquey e I. Dandouras. "Polar cap ion beams during periods of northward IMF: Cluster statistical results". Annales Geophysicae 29, n. 5 (6 maggio 2011): 771–87. http://dx.doi.org/10.5194/angeo-29-771-2011.
Testo completoAbstract (sommario):
Abstract. Above the polar caps and during prolonged periods of northward IMF, the Cluster satellites detect upward accelerated ion beams with energies up to a few keV. They are associated with converging electric field structures indicating that the acceleration is caused by a quasi-static field-aligned electric field that can extend to altitudes higher than 7 RE (Maggiolo et al., 2006; Teste et al., 2007). Using the AMDA science analysis service provided by the Centre de Données de la Physique des Plasmas, we have been able to extract about 200 events of accelerated upgoing ion beams above the polar caps from the Cluster database. Most of these observations are taken at altitudes lower than 7 RE and in the Northern Hemisphere. We investigate the statistical properties of these ion beams. We analyze their geometry, the properties of the plasma populations and of the electric field inside and around the beams, as well as their dependence on solar wind and IMF conditions. We show that ~40 % of the ion beams are collocated with a relatively hot and isotropic plasma population. The density and temperature of the isotropic population are highly variable but suggest that this plasma originates from the plasma sheet. The ion beam properties do not change significantly when the isotropic, hot background population is present. Furthermore, during one single polar cap crossing by Cluster it is possible to detect upgoing ion beams both with and without an accompanying isotropic component. The analysis of the variation of the IMF BZ component prior to the detection of the beams indicates that the delay between a northward/southward turning of IMF and the appearance/disappearance of the beams is respectively ~2 h and 20 min. The observed electrodynamic characteristics of high altitude polar cap ion beams suggest that they are closely connected to polar cap auroral arcs. We discuss the implications of these Cluster observations above the polar cap on the magnetospheric dynamics and configuration during prolonged periods of northward IMF.
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Potvin, Jean. "La physique de la matière hadronique à haute température telle que décrite par la chromodynamique quantique sur réseau espace–temps". Canadian Journal of Physics 67, n. 12 (1 dicembre 1989): 1228–49. http://dx.doi.org/10.1139/p89-206.
Testo completoAbstract (sommario):
The numerical simulation of quantum chromodynamics on a space–time lattice allows for the calculation of many properties of hadronic matter at high temperature in a direct and in a nonperturbative fashion. This paper will be a review of the calculation techniques and results published in the past 5 years. Among other things, I will discuss the order of the phase transition, the critical temperature, the force between heavy quarks, as well as the thermodynamics and the spectroscopy of the quark–gluon plasma.
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Zhang, Shuqing, Jingfeng Zhang, Fang Liu, Chao Zhou, Huajun Liu, Yi Shi, Peng Xu, Chengtao Wang, Qingjin Xu e Peng Gao. "Development of a cryogenic DC transformer using for the measurement of large current". Journal of Instrumentation 19, n. 02 (1 febbraio 2024): P02023. http://dx.doi.org/10.1088/1748-0221/19/02/p02023.
Testo completoAbstract (sommario):
Abstract Superconducting transformer is a typical facility used for inducing ultra-high current for large-scale scientific measurement systems, such as SULTAN-facility at the Centre de Recherches en Physique des Plasma (CRPP) in Switzerland, FRESCA-facility at CERN in Switzerland etc. A new program has been launched at the Institute of Plasma Physics, Chinese Academy of Sciences (ASIPP) to build a new conductor test facility to investigate the transverse pressure dependence of critical current of various superconducting cables using a compact superconducting transformer and cryogenic electromagnetic press systems. The superconducting transformer can induce a secondary current up to 60 kA, at a background magnetic field up to 15 T at 4.2 K. To measure the induced secondary current at cryogenic temperature precisely, three types of NbTi superconducting coils are designed based on the zero-flux principle to characterize the variation of the measured current. In this paper, the design principle of the cryogenic DC transformer and its commissioning results in a preliminary prototype test device are presented. The measurement results show achievements on accuracy of ±0.6% or less and nonlinearity of better than ±0.25%, which demonstrates the feasibility of the cryogenic DC transformer and provides a reliable technology for the secondary current measurement of a 100 kA superconducting transformer used in the program of Super-X test facility at ASIPP.
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Wang, Ze-Jun, Yu-Hang Zhang, Rong-Yao Gao, Hua-Bing Jia, Xiao-Jing Liu, Ya-Wen Hu, Qian-Qian Shao, Li-Min Fu e Jian-Ping Zhang. "Polystyrene Nanoparticle Uptake and Deposition in Silkworm and Influence on Growth". Sustainability 15, n. 9 (23 aprile 2023): 7090. http://dx.doi.org/10.3390/su15097090.
Testo completoAbstract (sommario):
This work reports the biological toxicity of nano plastic particles (NPs) to silkworms fed on the bait dopped with polystyrene encapsulated luminescent nanoparticles. The processes of NPs intake and excretion were monitored by means of time-gated optical imaging (TGI) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS), which allowed the quantification of the spatiotemporal deposition of NPs in an individual silkworm. The rates of NPs excretion and sequestration were found to be 99.92% and 0.08%, respectively, and the NPs retentate stayed mainly in the fat body (67.7%), digestive tract (18.0%), and head (7.54%). Adverse effects of NPs exposure were accordingly confirmed such as growth retardation and smaller physique. The results of the present work confirmed the possibility of nano-plastics accumulating and transmitting along the food chain in terrestrial ecosystems. The present work demonstrates the potential of employing silkworm as a model of full metamorphosed insects for exploring the biological impact of NPs on congeneric terrestrial animals, as well as the efficacy of the TGI-MS modality for in situ visualizing and quantifying the propagation of NPs via the primary food chain.
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Madsen, N., G. B. Andresen, M. D. Ashkezari, M. Baquero-Ruiz, W. Bertsche, P. D. Bowe, C. Bray et al. "Search for trapped antihydrogen in ALPHAThis paper was presented at the International Conference on Precision Physics of Simple Atomic Systems, held at École de Physique, les Houches, France, 30 May – 4 June, 2010." Canadian Journal of Physics 89, n. 1 (gennaio 2011): 7–16. http://dx.doi.org/10.1139/p10-085.
Testo completoAbstract (sommario):
Antihydrogen spectroscopy promises precise tests of the symmetry of matter and antimatter, and can possibly offer new insights into the baryon asymmetry of the universe. Antihydrogen is, however, difficult to synthesize and is produced only in small quantities. The ALPHA collaboration is therefore pursuing a path towards trapping cold antihydrogen to permit the use of precision atomic physics tools to carry out comparisons of antihydrogen and hydrogen. ALPHA has addressed these challenges. Control of the plasma sizes has helped to lower the influence of the multipole field used in the neutral atom trap, and thus lowered the temperature of the created atoms. Finally, the first systematic attempt to identify trapped antihydrogen in our system is discussed. This discussion includes special techniques for fast release of the trapped anti-atoms, as well as a silicon vertex detector to identify antiproton annihilations. The silicon detector reduces the background of annihilations, including background from antiprotons that can be mirror trapped in the fields of the neutral atom trap. A description of how to differentiate between these events and those resulting from trapped antihydrogen atoms is also included.
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Roberts, Justin, Anastasia Zinchenko, Krishnaa Mahbubani, James Johnstone, Lee Smith, Viviane Merzbach, Miguel Blacutt et al. "Satiating Effect of High Protein Diets on Resistance-Trained Subjects in Energy Deficit". Nutrients 11, n. 1 (28 dicembre 2018): 56. http://dx.doi.org/10.3390/nu11010056.
Testo completoAbstract (sommario):
Short-term energy deficit strategies are practiced by weight class and physique athletes, often involving high protein intakes to maximize satiety and maintain lean mass despite a paucity of research. This study compared the satiating effect of two protein diets on resistance-trained individuals during short-term energy deficit. Following ethical approval, 16 participants (age: 28 ± 2 years; height: 1.72 ± 0.03 m; body-mass: 88.83 ± 5.54 kg; body-fat: 21.85 ± 1.82%) were randomly assigned to 7-days moderate (PROMOD: 1.8 g·kg−1·d−1) or high protein (PROHIGH: 2.9 g·kg−1·d−1) matched calorie-deficit diets in a cross-over design. Daily satiety responses were recorded throughout interventions. Pre-post diet, plasma ghrelin and peptide tyrosine tyrosine (PYY), and satiety ratings were assessed in response to a protein-rich meal. Only perceived satisfaction was significantly greater following PROHIGH (67.29 ± 4.28 v 58.96 ± 4.51 mm, p = 0.04). Perceived cravings increased following PROMOD only (46.25 ± 4.96 to 57.60 ± 4.41 mm, p = 0.01). Absolute ghrelin concentration significantly reduced post-meal following PROMOD (972.8 ± 130.4 to 613.6 ± 114.3 pg·mL−1; p = 0.003), remaining lower than PROHIGH at 2 h (−0.40 ± 0.06 v −0.26 ± 0.06 pg·mL−1 normalized relative change; p = 0.015). Absolute PYY concentration increased to a similar extent post-meal (PROMOD: 84.9 ± 8.9 to 147.1 ± 11.9 pg·mL−1, PROHIGH: 100.6 ± 9.5 to 143.3 ± 12.0 pg·mL−1; p < 0.001), but expressed as relative change difference was significantly greater for PROMOD at 2 h (+0.39 ± 0.20 pg·mL−1 v −0.28 ± 0.12 pg·mL−1; p = 0.001). Perceived hunger, fullness and satisfaction post-meal were comparable between diets (p > 0.05). However, desire to eat remained significantly blunted for PROMOD (p = 0.048). PROHIGH does not confer additional satiating benefits in resistance-trained individuals during short-term energy deficit. Ghrelin and PYY responses to a test-meal support the contention that satiety was maintained following PROMOD, although athletes experiencing negative symptoms (i.e., cravings) may benefit from protein-rich meals as opposed to over-consumption of protein.
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Sa, QiLa, LiHong Bao, YaGeTu Hu, Haihua Bai e AGuLa Bo. "Study on the Metabonomics Mechanism of Mongolian Medical Andai Therapy on Healthy People". Evidence-Based Complementary and Alternative Medicine 2022 (20 giugno 2022): 1–14. http://dx.doi.org/10.1155/2022/1364408.
Testo completoAbstract (sommario):
Andai therapy is a traditional therapy combining body, mind, and language with Mongolian characteristics. In the form of singing and dancing, it is widely popular among people of all ages in Mongolian areas of Inner Mongolia. According to Mongolian medicine, Heyi is one of the three elements of human body, and it can maintain life activities, promote blood circulation, and improve the functions of the sensory and mental consciousness. Andai therapy stimulates the whole body nerves and Heyi through music and dance, improves Heyi and blood operation, strengthens physique, improves immunity, effectively promotes physical and mental health, and plays a role in preventing and treating diseases. Objective. In this study, gas chromatography-mass spectrometry (GC-MS) was used to explore the mechanism of Andai therapy, so as to provide a new research direction for taking targeted prevention and treatment measures for diseases. Methods. Using gas chromatography-mass spectrometry (GC-MS) on all its cases baseline plasma to the targeted metabonomics testing, the differential metabolites of the experimental group (receiving Andai therapy) and control group (without receiving Andai therapy), analysis-related metabolite function, and screening of metabolites and related pathways through adjusting mechanism to explore the related factors are compared, to study the mechanism of the influence of Mongolian medical Andai therapy on the metabolism of different healthy people. Results. The differences in metabolic numbers between the experimental group and the control group are 114, such as cyclohexylamine chlorinated acid, 2,4-2 aminobutyric acid bitter almond alcohol, l-methyl inosine, 2-picolinate, and 2-hydroxy-2-glutaric acid metabolite content of the control group that are significantly higher than the experimental group, experimental group’s other substance content is significantly higher than that of the control group, and two groups’ metabolite content was obviously different. The number of differential metabolites between the female experimental group and the female control group was 119, and the number of differential metabolites between the male experimental group and the male control group was 48.
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Khokhlov, A. M., D. I. Baranovsky, I. I. Goncharova, A. S. Fedyaeva e V. V. Karyaka. "Biological features of pigs of different productivity types in early ontogenesis". Veterinary science, technologies of animal husbandry and nature management, n. 6 (2020): 106–11. http://dx.doi.org/10.31890/vttp.2020.06.19.
Testo completoAbstract (sommario):
The morphogenetic period is the most important period of ontogenesis, the period of the highest activity of genes that provide the fundamental foundation and development of the main systems of the body. Breeding changes always begin with genetic changes that change the course of development and are realized in the phenotype. Thus, at the level of the phenotype selection plays an important role. The path from gene to trait is a major problem in developmental biology. The study was carried out on fetuses, embryos and newborn piglets of large white, Landrace and Mirgorod breed. The animal organism is an integral structure, where all organs, systems and tissues are interdependent and interconnected. Correlations preserve the organism as an integral structure. The study of biological patterns of development is of great practical importance in pig breeding. Their knowledge allows not only to improve existing breeds, breed types, but also allows to create new breeds and manage productivity. The directed development of the organism is influenced by the controlling factors of heredity in interaction with the environment. The intensity of metabolism is associated with its development and the formation of productive qualities. The type of animal can be the main factor in the assessment that determines the productivity of the animal. The type of animal includes its general appearance by which the productivity of the animal is determined. Meat, greasy and versatile types can be clearly distinguished. The main indicators that characterize the features of the morphogenetic period of ontogenesis are the following: live weight, height, development of the physique, internal organs, skeleton and muscle tissue. The role of blood in the body is very diverse. The main indicators for studying the properties of blood, its total amount, composition (the number of erythrocytes and leukocytes, the content of hemoglobin, protein, its fractions) are also relevant. In fetuses of Landrace and Large White breeds, along with high fertility, a greater number of blood cells and a high concentration of protein in the plasma of blood elements were revealed in comparison with fetuses and newborns of Mirgorod breed.
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Alexandre, R. "Sur l'approximation de Landau en physique des plasmas". Annales de l'Institut Henri Poincare (C) Non Linear Analysis 21, n. 1 (febbraio 2004): 61–95. http://dx.doi.org/10.1016/s0294-1449(03)00030-1.
Testo completo
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Harvey, C. C., C. Huc e M. Nonon-Latapie. "Centre de données de la physique des plasmas". Advances in Space Research 31, n. 5 (marzo 2003): 1291–95. http://dx.doi.org/10.1016/s0273-1177(02)00943-2.
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Trépanier, Michel. "De la physique des plasmas à la fusion nucléaire". Scientia Canadensis 16, n. 1 (8 luglio 2009): 25–59. http://dx.doi.org/10.7202/800341ar.
Testo completoAbstract (sommario):
RÉSUMÉ Cet article retrace l’émergence et le développement, au Canada et au Québec, des activités de recherche sur la fusion thermonucléaire au cours de la période 1960-1972. Intimement liés au développement de la physique des plasmas, l’histoire de la mise sur pied des principaux groupes de recherche intéressés à la fusion et le sort réservé aux premières tentatives visant à mettre en oeuvre un programme de recherche sur la fusion montrent bien comment des facteurs institutionnels, intellectuels, politiques, économiques et sociaux affectent le rythme de croissance et l’orientation de l’activité scientifique.
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Brault, Pascal, Jean-Marc Bauchire, Amaël Caillard, Anne-Lise Thomann, Mathieu Mougenot, Christophe Coutanceau, Steve Baranton et al. "Physique, Plasmas, Matériaux et Énergie : les piles à combustible". Reflets de la physique, n. 37 (dicembre 2013): 22–26. http://dx.doi.org/10.1051/refdp/201337022.
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Duval, A., I. Marinov, S. M. Starikovskaia, A. Rousseau e A. Janin. "Étude préclinique sur les applications cutanées des plasmas physiques : effets cellulaires et tissulaires d’un plasma froid nanoseconde". Annales de Dermatologie et de Vénéréologie 140, n. 12 (dicembre 2013): S500—S501. http://dx.doi.org/10.1016/j.annder.2013.09.316.
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Sarazin, Yanick. "Physique des plasmas - 9e Festival de Théorie à Aix-en-Provence". Reflets de la physique, n. 56 (gennaio 2018): 40–41. http://dx.doi.org/10.1051/refdp/201856040.
Testo completoAbstract (sommario):
La neuvième édition du « Festival de Théorie » de physique des plasmas s’est tenue du 26 juin au 20 juillet 2017. Tous les deux ans depuis 2001, l’Institut de recherche sur la fusion par confinement magnétique (IRFM) du CEA/Cadarache [1] organise cette manifestation scientifique internationale à Aix-en-Provence – un clin d’oeil aux nombreux festivals qui rythment la saison estivale dans la région – avec le concours d’Aix-Marseille Université.
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Rakotoson, Jean-Michel. "Un modèle non local en physique des plasmas: résolution par une méthode de degré topologique". Acta Applicandae Mathematicae 4, n. 1 (luglio 1985): 1–14. http://dx.doi.org/10.1007/bf02293489.
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Kado, Yoko, Fumiaki Kitazawa, Masayuki Tsujimoto, Shin-ichi Fuchida, Akira Okano, Mayumi Hatsuse, Satoshi Murakami et al. "Prediction of the Lenalidomide Toxicity and Its Therapeutic Efficacy in Japanese Multiple Myeloma Patients By Measuring Its Plasma Concentration." Blood 126, n. 23 (3 dicembre 2015): 3700. http://dx.doi.org/10.1182/blood.v126.23.3700.3700.
Testo completoAbstract (sommario):
Abstract Lenalidomide (Len), an immunomodulatory drug, has significant clinical activity in patients with relapsed and refractory multiple myeloma (MM), and it is usually administered at a dose of 25 mg daily. For Len to exert its therapeutic effects with minimum adverse effects, it is important to determine the most suitable dosage on the basis of the physiques and body surface area (BSA) of patients. We investigated the relationship between pharmacokinetic variability of this drug and its toxicity and therapeutic efficacy. The institutional review boards and ethics committees at both participating centers approved the study protocol and all patients provided written informed consent. Thirteen Japanese patients with relapsed and refractory MM were enrolled in this study. They were treated with Len at 10-25 mg for 21 days every 4 weeks. The dose of Len administered to patients with renal dysfunction was reduced according to consensus statements on the optimal use of Len. Dexamethasone at 8-40 mg weekly was added to each drug cycle. Peripheral blood was collected three hours after Len administration in the first cycle and the plasma concentration of Len was evaluated using high performance liquid chromatography. Response and progression were assessed according to the International Myeloma Working Group criteria and the severity of adverse events was graded according to the Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. The median values of age (years) and estimated creatinine clearance (eCLcr, mL/min) of the 13 enrolled patients (male to female ratio=5:8) were 69 and 66.3, respectively. The number of patients in stages I, II, and III or the unknown stage of the International Staging System were 8, 1, 2, and 2, respectively. The number of the patients who achieved the best responses during three cycles of treatment were one (7.7%) in complete response, four (30.8%) in partial response, and eight (61.5%) in stable disease. The percentage of hematological adverse events (Grade 3/4) was 38.5% and no non-hematological events (Grade 3/4) were observed. The Len concentration ranged from 172.5 ng/mL to 555.6 ng/mL with a median concentration of 341.8 ng/mL. eCLcr values did not correlate with Len concentrations, but significantly correlated with C/D ratios (p <0.005, Figure 1). We next evaluated the correlation between Len concentration and the severity of adverse events. The percentage of patients with any Grade 1/2 adverse event and the percentage of those with Grade 3/4 adverse events were 61.5% (8/13) and 38.5% (5/13), respectively. A Receiver Operating Characteristic curve analysis of Len concentrations was used to determine an optimal cutoff value with the Youden index. The percentage of severely of any Grade 3/4 adverse event for patients with ≥ 320 ng/mL Len was 62.5% (5/8), and that of patients with <320 ng/mL was zero (0/5). The Fisher's exact test demonstrated that the severity of adverse effects significantly correlated with the Len concentration (Table 1, p <0.05). However, there was no correlation between Len concentrations and best responses. These findings indicate that it is possible to avoid severe adverse events without reducing therapeutic efficacy by monitoring Len concentrations. In conclusion, this pilot study suggests that it is important to determine the Len dosage on the basis of its plasma concentration. This issue should be clarified further in a large-scale study. Disclosures Kado: Japan Community Health Care Organization Kyoto Kuramaguchi Medical Center: Employment. Kitazawa:Japan Community Health Care Organization Kyoto Kuramaguchi Medical Center: Employment. Fuchida:Japan Community Health Care Organization Kyoto Kuramaguchi Medical Center: Employment. Okano:Japan Community Health Care Organization Kyoto Kuramaguchi Medical Center: Employment. Hatsuse:Japan Community Health Care Organization Kyoto Kuramaguchi Medical Center: Employment. Murakami:Japan Community Health Care Organization Kyoto Kuramaguchi Medical Center: Employment. Ueda:Japan Community Health Care Organization Kyoto Kuramaguchi Medical Center: Employment. Kokufu:Japan Community Health Care Organization Kyoto Kuramaguchi Medical Center: Employment. Shimazaki:Japan Community Health Care Organization Kyoto Kuramaguchi Medical Center: Employment.
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Terekhov, Vladimir A., Evgeny I. Terukov, Yury K. Undalov, Konstantin A. Barkov, Igor E. Zanin, Oleg V. Serbin e Irina N. Trapeznikova. "Structural Rearrangement of a-SiOx:H Films with Pulse Photon Annealing". Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 22, n. 4 (15 dicembre 2020): 489–95. http://dx.doi.org/10.17308/kcmf.2020.22/3119.
Testo completoAbstract (sommario):
Amorphous SiOx films with silicon nanoclusters are a new interesting material from the standpoint of the physics, technology, and possible practical applications, since such films can exhibit photoluminescence due to size quantization. Moreover, the optical properties of these structures can be controlled by varying the size and the content of silicon nanoclusters in the SiOx film, as well as by transforming nanoclusters into nanocrystals by means of high-temperature annealing. However, during the annealing of nonstoichiometric silicon oxide, significant changes can occur in the phase composition and the structure of the films. The results of investigations on the crystallization of silicon nanoclusters in a SiOx matrix have shownthat, even a very fast method of annealing using PPA leads to the formation of large silicon crystallites. This also causes the crystallization of at least a part of the oxide phase in the form of silicon hydroxide H6O7Si2. Moreover, in films with an initial content of pure silicon nanoclusters ≤ 50%, during annealing a part of the silicon is spent on the formation of oxide, and part of it is spent on the formation of silicon crystals. While in a film with an initial concentration of silicon nanoclusters ≥ 53%, on the contrary, upon annealing, there occurs a partial transition of silicon from the oxide phase to the growth ofSi crystals
Reference
1. Undalov Y. K., Terukov E. I., Silicon nanoclustersncl-Si in a hydrogenated amorphous silicon suboxidematrix a-SiOx:H (0 < x < 2). Semiconductors. 2015;49(7):867- 878. DOI: https://doi.org/10.1134/S10637826150702222. Kim K. H., Johnson E. V., Kazanskii A. G.,Khenkin M. V., Roca P. Unravelling a simple methodfor the low temperature synthesis of siliconnanocrystals and monolithic nanocrystalline thinfilms. Scientific Reports. 2017;7(1) DOI: https://doi.org/10.1038/srep405533. Undalov Y. K., Terukov E. I., Trapeznikova I. N.Formation of ncl-Si in the amorphous matrix a-SiOx-:H located near the anode and on the cathode, usinga time-modulated DC plasma with the (SiH4–Ar–O2)gas phase (Co2 = 21.5 mol%). Semiconductors.2019;53(11): 1514–1523. DOI: https://doi.org/10.1134/S10637826191102284. Terekhov V. A., Terukov E. I., Undalov Y. K.,Parinova E. V., Spirin D. E., Seredin P. V., Minakov D. A.,Domashevskaya E. P. Composition and optical propertiesof amorphous a-SiOx:H films with silicon nanoclusters.Semiconductors. 2016;50(2): 212–216. DOI:https://doi.org/10.1134/S10637826160202515. Terekhov V. A., Turishchev S. Y., Kashkarov V. M.,Domashevskaya E. P., Mikhailov A. N., Tetel’baum D. I.Silicon nanocrystals in SiO2 matrix obtained by ionimplantation under cyclic dose accumulation. PhysicaE: Low-dimensional Systems and Nanostructures.2007;38(1-2): 16–20. DOI: https://doi.org/10.1016/j.physe.2006.12.0306. Terekhov V. A., Turishchev S. Y., Pankov K. N.,Zanin I. E., Domashevskaya E. P., Tetelbaum D. I.,Mikhailov A. N., Belov A. I., Nikolichev D. E., Zubkov S. Y.XANES, USXES and XPS investigations of electronenergy and atomic structure peculiarities of the siliconsuboxide thin film surface layers containing Si nanocrystals.Surface and Interface Analysis. 2010;42(6-7):891–896. DOI: https://doi.org/10.1002/sia.33387. Terekhov V. A., Turishchev S. Y., Pankov K. N.,Zanin I. E., Domashevskaya E. P., Tetelbaum, MikhailovA. N., Belov A. I., Nikolichev D. E. Synchrotron investigationsof electronic and atomic-structure peculiaritiesfor silicon-oxide films’ surface layers containingsilicon nanocrystals. Journal of Surface Investigation.X-ray, Synchrotron and Neutron Techniques. 2011;5(5):958–967. DOI: https://doi.org/10.1134/S102745101110020X8. Sato K., Izumi T., Iwase M., Show Y., Morisaki H.,Yaguchi T., Kamino T. Nucleation and growth of nanocrystallinesilicon studied by TEM, XPS and ESR.Applied Surface Science. 2003;216 (1-4): 376–381. DOI:https://doi.org/10.1016/S0169-4332(03)00445-89. Ledoux G., Gong J., Huisken F., Guillois O., ReynaudC. Photoluminescence of size-separated siliconnanocrystals: Confirmation of quantum confinement.Applied Physics Letters. 2002;80(25): 4834–4836. DOI:https://doi.org/10.1063/1.148530210. Patrone L., Nelson D., Safarov V. I., Sentis M.,Marine W., Giorgio S. Photoluminescence of siliconnanoclusters with reduced size dispersion producedby laser ablation. Journal of Applied Physics. 2000;87(8):3829–3837. DOI: https://doi.org/10.1063/1.37242111. Takeoka S., Fujii M., Hayashi S. Size-dependentphotoluminescence from surface-oxidized Si nanocrystalsin a weak confinement regime. Physical ReviewB. 2000;62(24): 16820–16825. DOI: https://doi.org/10.1103/PhysRevB.62.1682012. Ievlev V. M. Activation of solid-phase processesby radiation of gas-discharge lamps, Russian ChemicalReviews. 2013;82(9): 815–834. DOI: https://doi.org/10.1070/rc2013v082n09abeh00435713. Zimkina T. M., Fomichev V. A. Ultrasoft X-Rayspectroscopy. Leningrad: Leningrad State UniversityPubl.; 1971. 132 p.14. Wiech G., Feldhütter H. O., Šimůnek A. Electronicstructure of amorphous SiOx:H alloy filmsstudied by X-ray emission spectroscopy: Si K, Si L, andO K emission bands. Physical Review B. 1993;47(12):6981–6989. DOI: https://doi.org/10.1103/Phys-RevB.47.698115. Domashevskaya E. P., Peshkov Y. A., TerekhovV. A., Yurakov Y. A., Barkov K. A., Phase compositionof the buried silicon interlayers in the amorph o u s m u l t i l a y e r n a n o s t r u c t u r e s[(Co45Fe45Zr10)/a-Si:H]41 and [(Co45Fe45Zr10)35(Al2O3)65/a-Si:H]41. Surface and Interface Analysis.2018;50(12-13): 1265–1270. DOI: https://doi.org/10.1002/sia.651516. Terekhov V. A., Kashkarov V. M., ManukovskiiE. Yu., Schukarev A. V., Domashevskaya E. P.Determination of the phase composition of surfacelayers of porous silicon by ultrasoft X-ray spectroscopyand X-ray photoelectron spectroscopy techniques.Journal of Electron Spectroscopy and Related Phenomena.2001;114–116: 895–900. DOI: https://doi.org/10.1016/S0368-2048(00)00393-517. JCPDS-International Centre for DiffractionData ICDD PDF-2, (n.d.) card No 01-077-2110.18. JCPDS-International Centre for DiffractionData ICDD PDF-2, (n.d.) card No 00-050-0438.
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DOYEUX, Henri. "Affichage. Visualisation - Écrans à plasma. Physique. Fabrication". Optique Photonique, giugno 2005. http://dx.doi.org/10.51257/a-v1-r610.
Testo completo
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Morishita, Toshimasa, Naoto Nishizaki, Sakiko Taniguchi, Shinsuke Sakai, Tomonori Kimura, Masashi Mita, Mayu Nakagawa et al. "Plasma d-asparagine and the d/l-serine ratio reflect chronic kidney diseases in children regardless of physique". Amino Acids 56, n. 1 (6 giugno 2024). http://dx.doi.org/10.1007/s00726-024-03400-x.
Testo completoAbstract (sommario):
AbstractBiomarkers that accurately reflect renal function are essential in management of chronic kidney diseases (CKD). However, in children, age/physique and medication often alter established renal biomarkers. We studied whether amino acid enantiomers in body fluids correlate with renal function and whether they are influenced by physique or steroid medication during development. We conducted a prospective study of children 2 to 18 years old with and without CKD. We analyzed associations of serine/asparagine enantiomers in body fluids with major biochemical parameters as well as physique. To study consequences of kidney dysfunction and steroids on serine/asparagine enantiomers, we generated juvenile mice with uninephrectomy, ischemic reperfusion injury, or dexamethasone treatment. We obtained samples from 27 children, of which 12 had CKD due to congenital (n = 7) and perinatal (n = 5) causes. Plasma d-asparagine and the d/l-serine ratio had robust, positive linear associations with serum creatinine and cystatin C, and detected CKD with high sensitivity and specificity, uninfluenced by body size or biochemical parameters. In the animal study, kidney dysfunction increased plasma d-asparagine and the d/l-serine ratio, but dexamethasone treatment did not. Thus, plasma d-asparagine and the d/l-serine ratio can be useful markers for renal function in children.
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Brummund, Dieter, e Tarik Husain. "Abdominal Etching with Renuvion Helium Plasma". Aesthetic Surgery Journal Open Forum 6, Supplement_1 (12 aprile 2024). http://dx.doi.org/10.1093/asjof/ojae007.074.
Testo completoAbstract (sommario):
Abstract Goals/Purpose Differential liposuction with abdominal etching is a powerful technique in high definition liposculpture to achieve an athletic aesthetic. Etching is performed in a superficial plane to create indentures mirroring the dermal-fascial inscriptions of the underlying desired musculature. Renuvion radiofrequency-helium plasma energy (Apyx Medical, Clearwater, FL) is an emerging technology that is used for subdermal coagulation and contraction of the subcutaneous tissue. This case series describes combination of differential liposuction with abdominal etching and Renuvion helium plasma subdermal coagulation in 68 patients and evaluates the outcomes. Methods/Technique A retrospective chart review of 68 patients undergoing differential liposuction with abdominal etching and Renuvion helium plasma subdermal coagulation between 2021 to 2023 by the senior author. The preoperative evaluation, markings, surgical technique and postoperative care are discussed. Clinical parameters assessed include age, gender, body mass index, combination of procedures, volume of lipoaspirate, degree of etching (light, moderate, deep), postoperative changes in weight, and complications such as contour irregularity, wound dehiscence, seroma, surgical site infection, patient dissatisfaction and operative revision. Results/Complications 68 consecutive patients who underwent abdominal etching with Renuvion by the senior author between July 2021 and August 2023 were included in this case series. There were 29 males (43%) and 39 females (57%). The average age of the patients was 39.11 (range, 22 to 64 years), with a non obese, average body mass index of 27.65 kg/m2 (range, 20.8 to 33.9 kg/m2). The average estimated intraoperative blood loss of patients was 104.68 ml (range, 75 to 150 ml); with an average tumescence of 4600 ml (range, 1400 to 8000 ml). The average lipoaspirate was 3920 ml (range, 500 to 9000 ml). In addition to the abdominal region, other areas liposuctioned at the time of etching included flanks (68, 100%), back (66, 97.05%), thighs (14, 20.58%), arms (9, 13.23%), neck (9, 13.23%), chest (8, 11.76%), axilla (3, 4.41%), calves (1, 1.47%). Use of ultrasound was used in 6 cases (8.82%), which were revisionary liposuction. Of our 68 abdominal etching with Renuvion cases the most common combined procedure was autologous fat transfer (20, 29.41%), platysmaplasty (4, 5.88%), mastopexy (5, 8%), breast augmentation (4, 5.88%), buccal fat pad excision (3, 4.41%), umbilical hernia repair (1, 1.47%) and rhytidectomy (1, 1.47%). There were 5 cases of seroma (7.35%) and 4 cases of contour irregularity (5.88%). There were 3 cases of surgical site infection (4.41%), but all in the area of fat grafting and not in the area of liposculpture. No cases of hyperpigmentation were identified. No major complications occurred including skin burns, skin necrosis, visceral injury, deep vein thrombosis, or pulmonary embolism. Overall 66 patients (97.05%) were satisfied following their procedure. Operative revision occurred in two patients (2.94%), who had residual skin laxity following Renuvion and desired skin excision. Conclusion Differential liposuction with abdominal etching and Renuvion helium plasma are safe and effective in combination to synergistically achieve an athletic physique and enhance abdominal aesthetics. Complication rates are low with appropriate surgical technique. Almost all patients reviewed were satisfied with the procedure and maintained long-term results.
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Safaei, Soroush, Veronique De Brabandere, Wilhelmus E. A. de Witte, Lindsay B. Avery, Tom Van Bogaert e Maria Laura Sargentini-Maier. "Reproducibility Study on a PBPK Model of FcRn-Mediated Recycling for Large Molecules". Physiome, 9 febbraio 2024. http://dx.doi.org/10.36903/physiome.25194020.
Testo completoAbstract (sommario):
The PBPK model of FcRn-mediated recycling of large molecules was developed and studied by \cite{de2023mechanistic} to characterize and predict Immunoglobulin G (IgG) disposition in plasma and tissues. This study investigated the large-molecule model in PK-Sim and its applicability to molecules with FcRn binding affinity in plasma. Subsequently, the model was extended to ensure a more mechanistic description of the internalization of FcRn and the FcRn-drug complex. This PBPK model has applications in autoimmune disorders such as primary immune thrombocytopenia which is mediated partly by platelet autoantibodies, resulting in thrombocytopenia, bleeding, and constitutional symptoms. Currently, there are several FcRn inhibitors in clinical development for numerous indications that can benefit from this model. We created a modular implementation of the model in MoBi, which is able to reproduce the originally published data. This Physiome paper describes how to access, run, and manipulate this model, how to parameterize the model to match data, and how to compare model predictions to data. In addition, some inconsistencies have been revealed and discussed in this paper. EDITOR'S NOTE v2: adding OMEX archive. v3: correcting file names.
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Safaei, Soroush, Veronique De Brabandere, Wilhelmus E. A. de Witte, Lindsay B. Avery, Tom Van Bogaert e Maria Laura Sargentini-Maier. "Reproducibility Study on a PBPK Model of FcRn-Mediated Recycling for Large Molecules". Physiome, 9 febbraio 2024. http://dx.doi.org/10.36903/physiome.25194020.v2.
Testo completoAbstract (sommario):
The PBPK model of FcRn-mediated recycling of large molecules was developed and studied by \cite{de2023mechanistic} to characterize and predict Immunoglobulin G (IgG) disposition in plasma and tissues. This study investigated the large-molecule model in PK-Sim and its applicability to molecules with FcRn binding affinity in plasma. Subsequently, the model was extended to ensure a more mechanistic description of the internalization of FcRn and the FcRn-drug complex. This PBPK model has applications in autoimmune disorders such as primary immune thrombocytopenia which is mediated partly by platelet autoantibodies, resulting in thrombocytopenia, bleeding, and constitutional symptoms. Currently, there are several FcRn inhibitors in clinical development for numerous indications that can benefit from this model. We created a modular implementation of the model in MoBi, which is able to reproduce the originally published data. This Physiome paper describes how to access, run, and manipulate this model, how to parameterize the model to match data, and how to compare model predictions to data. In addition, some inconsistencies have been revealed and discussed in this paper.
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Safaei, Soroush, Veronique De Brabandere, Wilhelmus E. A. de Witte, Lindsay B. Avery, Tom Van Bogaert e Maria Laura Sargentini-Maier. "Reproducibility Study on a PBPK Model of FcRn-Mediated Recycling for Large Molecules". Physiome, 25 febbraio 2024. http://dx.doi.org/10.36903/physiome.25194020.v5.
Testo completoAbstract (sommario):
The PBPK model of FcRn-mediated recycling of large molecules was developed and studied by \cite{de2023mechanistic} to characterize and predict Immunoglobulin G (IgG) disposition in plasma and tissues. This study investigated the large-molecule model in PK-Sim and its applicability to molecules with FcRn binding affinity in plasma. Subsequently, the model was extended to ensure a more mechanistic description of the internalization of FcRn and the FcRn-drug complex. This PBPK model has applications in autoimmune disorders such as primary immune thrombocytopenia which is mediated partly by platelet autoantibodies, resulting in thrombocytopenia, bleeding, and constitutional symptoms. Currently, there are several FcRn inhibitors in clinical development for numerous indications that can benefit from this model. We created a modular implementation of the model in MoBi, which is able to reproduce the originally published data. This Physiome paper describes how to access, run, and manipulate this model, how to parameterize the model to match data, and how to compare model predictions to data. In addition, some inconsistencies have been revealed and discussed in this paper. EDITOR'S NOTE v2: adding OMEX archive. v3: correcting file names. v4: updating publication date. v5: updating OMEX archive.
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Safaei, Soroush, Veronique De Brabandere, Wilhelmus E. A. de Witte, Lindsay B. Avery, Tom Van Bogaert e Maria Laura Sargentini-Maier. "Reproducibility Study on a PBPK Model of FcRn-Mediated Recycling for Large Molecules". Physiome, 9 febbraio 2024. http://dx.doi.org/10.36903/physiome.25194020.v3.
Testo completoAbstract (sommario):
The PBPK model of FcRn-mediated recycling of large molecules was developed and studied by \cite{de2023mechanistic} to characterize and predict Immunoglobulin G (IgG) disposition in plasma and tissues. This study investigated the large-molecule model in PK-Sim and its applicability to molecules with FcRn binding affinity in plasma. Subsequently, the model was extended to ensure a more mechanistic description of the internalization of FcRn and the FcRn-drug complex. This PBPK model has applications in autoimmune disorders such as primary immune thrombocytopenia which is mediated partly by platelet autoantibodies, resulting in thrombocytopenia, bleeding, and constitutional symptoms. Currently, there are several FcRn inhibitors in clinical development for numerous indications that can benefit from this model. We created a modular implementation of the model in MoBi, which is able to reproduce the originally published data. This Physiome paper describes how to access, run, and manipulate this model, how to parameterize the model to match data, and how to compare model predictions to data. In addition, some inconsistencies have been revealed and discussed in this paper. EDITOR'S NOTE v2: adding OMEX archive. v3: correcting file names.
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Safaei, Soroush, Veronique De Brabandere, Wilhelmus E. A. de Witte, Lindsay B. Avery, Tom Van Bogaert e Maria Laura Sargentini-Maier. "Reproducibility Study on a PBPK Model of FcRn-Mediated Recycling for Large Molecules". Physiome, 13 marzo 2024. http://dx.doi.org/10.36903/physiome.25194020.v6.
Testo completoAbstract (sommario):
The PBPK model of FcRn-mediated recycling of large molecules was developed and studied by \cite{de2023mechanistic} to characterize and predict Immunoglobulin G (IgG) disposition in plasma and tissues. This study investigated the large-molecule model in PK-Sim and its applicability to molecules with FcRn binding affinity in plasma. Subsequently, the model was extended to ensure a more mechanistic description of the internalization of FcRn and the FcRn-drug complex. This PBPK model has applications in autoimmune disorders such as primary immune thrombocytopenia which is mediated partly by platelet autoantibodies, resulting in thrombocytopenia, bleeding, and constitutional symptoms. Currently, there are several FcRn inhibitors in clinical development for numerous indications that can benefit from this model. We created a modular implementation of the model in MoBi, which is able to reproduce the originally published data. This Physiome paper describes how to access, run, and manipulate this model, how to parameterize the model to match data, and how to compare model predictions to data. In addition, some inconsistencies have been revealed and discussed in this paper. EDITOR'S NOTE v2: adding OMEX archive. v3: correcting file names. v4: updating publication date. v5: updating OMEX archive. v6: attaching CRBM report.
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Safaei, Soroush, Veronique De Brabandere, Wilhelmus E. A. de Witte, Lindsay B. Avery, Tom Van Bogaert e Maria Laura Sargentini-Maier. "Reproducibility Study on a PBPK Model of FcRn-Mediated Recycling for Large Molecules". Physiome, 11 febbraio 2024. http://dx.doi.org/10.36903/physiome.25194020.v4.
Testo completoAbstract (sommario):
The PBPK model of FcRn-mediated recycling of large molecules was developed and studied by \cite{de2023mechanistic} to characterize and predict Immunoglobulin G (IgG) disposition in plasma and tissues. This study investigated the large-molecule model in PK-Sim and its applicability to molecules with FcRn binding affinity in plasma. Subsequently, the model was extended to ensure a more mechanistic description of the internalization of FcRn and the FcRn-drug complex. This PBPK model has applications in autoimmune disorders such as primary immune thrombocytopenia which is mediated partly by platelet autoantibodies, resulting in thrombocytopenia, bleeding, and constitutional symptoms. Currently, there are several FcRn inhibitors in clinical development for numerous indications that can benefit from this model. We created a modular implementation of the model in MoBi, which is able to reproduce the originally published data. This Physiome paper describes how to access, run, and manipulate this model, how to parameterize the model to match data, and how to compare model predictions to data. In addition, some inconsistencies have been revealed and discussed in this paper. EDITOR'S NOTE v2: adding OMEX archive. v3: correcting file names. v4: updating publication date.
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Janssens, Georges E., Lotte Grevendonk, Bauke V. Schomakers, Ruben Zapata Perez, Michel van Weeghel, Patrick Schrauwen, Joris Hoeks e Riekelt H. Houtkooper. "A metabolomic signature of decelerated physiological aging in human plasma". GeroScience, 31 maggio 2023. http://dx.doi.org/10.1007/s11357-023-00827-0.
Testo completoAbstract (sommario):
Abstract The degenerative processes that occur during aging increase the risk of disease and impaired health. Meanwhile, interventions that target aging to promote healthy longevity are gaining interest, both academically and in the public. While nutritional and physical interventions exist, efficacy is often difficult to determine. It is therefore imperative that an aging score measuring the biological aging process is available to the wider public. However, simple, interpret, and accessible biological aging scores are lacking. Here, we developed PhysiAge, a physiological aging score based on five accessible parameters that have influence on or reflect the aging process: (1) average daily step count, (2) blood glucose, (3) systolic blood pressure, (4) sex, and (5) age. Here, we found that compared to calendar age alone, PhysiAge better predicts mortality, as well as established muscle aging markers such as decrease in NAD+ levels, increase in oxidative stress, and decline in physical functioning. In order to demonstrate the usefulness of PhysiAge in identifying relevant factors associated with decelerated aging, we calculated PhysiAges for a cohort of aged individuals and obtained mass spectrometry-based blood plasma metabolomic profiles for each individual. Here, we identified a metabolic signature of decelerated aging, which included components of the TCA cycle, including malate, citrate, and isocitrate. Higher abundance of these metabolites was associated with decelerated aging, in line with supplementation studies in model organisms. PhysiAge represents an accessible way for people to track and intervene in their aging trajectories, and identifies a metabolic signature of decelerated aging in human blood plasma, which can be further studied for its causal involvement in human aging.
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Hey, John Douglas. "On the Pasternack-Sternheimer theorem for bound states in hydrogenic atoms and ions derived by operator calculus". Journal of Physics A: Mathematical and Theoretical, 14 settembre 2022. http://dx.doi.org/10.1088/1751-8121/ac9201.
Testo completoAbstract (sommario):
Abstract The Pasternack-Sternheimer theorem for bound states (Pasternack S and Sternheimer R M 1962 J. Math. Phys. 3 1280) is obtained directly by the methods of operator calculus set out earlier (Hey J D 2006 J. Phys. B: At. Mol. Opt. Phys. 39 2641), on the basis of the factorisation technique of Infeld and Hull (Infeld L and Hull T E 1951 Rev. Mod. Phys. 23 21). The present derivation, which complements the group theoretical treatments of Armstrong (Armstrong L L Jr 1970 J. Physique Colloques 31 C4-17) and Cunningham (Cunningham M J 1972 J. Math. Phys. 13 33), not only elucidates the original result in terms of fundamental quantum mechanical theory, but also reveals some apparently new inter-connections between different radial matrix elements (for given n, diagonal and off-diagonal in , ' ) of hydrogenic atoms and ions. The key equation used to derive the Theorem here is shown to follow identically in the non-relativistic limit from the treatment of the generalised Kepler problem by Crubellier and Feneuille (Crubellier A and Feneuille S 1971 Journal de Physique 32 405). This work is a continuation of studies employing operator methods to provide results of potential usefulness for spectroscopic studies of laboratory and astrophysical plasmas, in particular to transitions between states of high principal quantum number, as in the high-n radio recombination lines (Hey J D 2013 J. Phys. B: At. Mol. Opt. Phys. 46 175702); Peach G 2014 Adv. Space Res. 54 1180).