Letteratura scientifica selezionata sul tema "Phtalate de dibutyle – Toxicologie"
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Tesi sul tema "Phtalate de dibutyle – Toxicologie":
Yedji, Rodrigue. "Perturbateurs endocriniens de type phtalate et poisson zèbre Danio rerio : approche chémoprotéomique pour l'identification des cibles et recherche de signatures d'exposition". Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0106.
Phthalate esters are a family of synthetic compounds widely used as plasticisers. They are used in a number of plastic products such as packaging, toys, cosmetics, plastic roofing system and furniture decoration materials. Phthalates are not covalently bonded to the polymer matrix and are therefore easily released into the environment, resulting in animal and human exposure. In the absence of non-toxic substitutes, phthalate compounds are still widely used in industry, despite the classification of some of them by the European Chemicals Agency (ECHA) as suspected toxic substances and as endocrine disruptors. In addition, they are carcinogenic and teratogenic. The deleterious effect of phthalate esters on organisms is established, but the multiple nature of the effects observed shows that the mechanisms of action of phthalates are only partially elucidated. We used two targeted proteomics approaches to shed light on the mechanisms of action of phthalate esters. Dibutyl phthalate (DBP) was used as a model phthalate and zebrafish (D. rerio) as a model organism. Using the first targeted proteomics approach, affinity-based protein profiling (AfBPP), the functional disruption of proteins by DBP with photoaffinity probes from aryl azide synthesis was demonstrated. Optimisation of the binding conditions for diazirine probes (Diazirine 2) should provide us with a probe that can be used to identify DBP protein targets in the zebrafish proteome. The second approach, activity-based protein profiling (ABPP), used a reactive probe specific for serine hydrolases (SHs) to map active SHs in the zebrafish proteome for the first time. The identification of deregulated SHs in the presence of DBP in zebrafish larvae was also reported in this study. Overall, our results indicate that targeted proteomics approaches such as ABPP or AfBPP can be an asset for understanding xenobiotic-related mechanisms of action in ecotoxicology
Lehraiki, Abdelali. "Effets et mécanismes d'action du Mono (2-ethylhexyl) phtalate (MEHP) sur le développement du testicule foetal et neonatal de souris in vitro". Paris 7, 2010. http://www.theses.fr/2010PA077100.
Phthalate esters are a class of endocrine disrupting chemicals widely distributed in the environment. Numerous studies, conducted almost exclusively in the rat have shown that in utero exposure to phthalates results in deleterious effects on fetal testis. A few recent studies reported that phthalates also have deleterious effects on human fetal testis in vitro but the alterations described do not exactly match those in the rat and the mechanisms of action of these chemicals are largely unkhown. We defined specific periods of sensitivity of the mouse fetal testis to MEHP for steroidogenesis and gametogenesis. MEHP induced a severe and early decrease in the number of gonocytes due to massive apoptosis. Similar effects have recently been observed in vitro in the rat and in the human fetal testis. In contrast, effects on steroidogenesis were different from that described in both rat and human species. Therefore our work show that the deleterious effects of phthalates on steroidogenesis vary according to species and developmental stage, while the effects on gerrn cell development are similar in various mammalian species. Therefore, the effects bf phthalates on steroidogenesis are unrelated to those on gametogenesis. Using mouse deficient for ERo; ER/3 and AR (Tfm mouse) we defînitively eliminated the hypothesis of direct or indirect effect of MEHP on gametogenesis and steroidogenesis through antiandrogenic/estrogenic pathways. Finally, we demonstrated for the first time the implication of retinoic acid pathway in MEHP induced germ cells apoptosis. These results offer new clues to understand the mechanisms of action of phthalates in the fetal
Wakx, Anaïs. "Etude de nouveaux biomarqueurs de toxicité induite par des micropolluants (benzo(a)pyrène et phtalate de bis(2-ethylhexyle)) sur des modèles de placenta humain". Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P620/document.
Prenatal exposure to pollutants is commonly evaluated using placenta as a barrier between mother and fetus. Here, we consider placenta as a target organ for toxic agents. To achieve this, we selected a trophoblastic cell model, which is adapted to toxicological studies. In clinical studies, pregnancy pathologies are associated to changes in human placental lactogen (hPL) and human chorionic gonadotropin (hCG) secretions. Our in vitro work links exposure to micropollutants (mono(2-ethylhexyl)phthalate, an endocrine disruptor, and benzo(a)pyrene, a carcinogen) and clinical observations. We identified biomarkers of hormonal secretion (hPL and hyperglycosylated hCG) and degeneration (P2X7 receptor activation), which enable the evaluation of exposure and risk attached to exposure to pollutants
Libri sul tema "Phtalate de dibutyle – Toxicologie":
Canada, Canada Environnement. Phtalate de butyle et de benzyle. Ottawa, Ont: Environnement Canada, 2000.
Canada, Canada Environment, e Canada Health Canada, a cura di. Dibutyl phthalate. [Ottawa]: Environment Canada, 1994.