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1
Zirzow, Karl-Heinz, e Alfred Schmidpeter. "Dialkylamino-phenyldi- und -triphosphide aus dem (PhP)5-Abbau mit Alkaliamiden / Dialkylamino-phenyldi- and -triphosphides from the Degradation of (PhP)5 by Alkali Amides". Zeitschrift für Naturforschung B 42, n. 9 (1 settembre 1987): 1083–87. http://dx.doi.org/10.1515/znb-1987-0905.
Testo completoAbstract (sommario):
(PhP)5 and lithium dialkylamides in tetrahydrofuran form equilibrium mixtures of lithium aminophenylphosphides (PhP)nNR- with n = 3 and (mainly) 2. The monophosphides (n = 1) are not formed; it is concluded that they are generally unstable, decomposing to aminodiphosphides and cyclophosphines. Alkylation of an equilibrium mixture gives 1-alkyl-2-dialkylamino-diphenyl- diphosphines which, however, are thermally unstable. (PhP)5 degradation equilibria using different anionic nucleophiles are compared.
2
Ehrlich, Lisa, Robert Gericke, Erica Brendler e Jörg Wagler. "P–Ru-Complexes with a Chelate-Bridge-Switch: A Comparison of 2-Picolyl and 2-Pyridyloxy Moieties as Bridging Ligands". Molecules 27, n. 9 (27 aprile 2022): 2778. http://dx.doi.org/10.3390/molecules27092778.
Testo completoAbstract (sommario):
Starting from [Ru(pyO)2(nbd)] 1 and a N,P,N-tridentate ligand (2a: PhP(pic)2, 2b: PhP(pyO)2) (nbd = 2,5-norbornadiene, pic = 2-picolyl = 2-pyridylmethyl, pyO = 2-pyridyloxy = pyridine-2-olate), the compounds [PhP(μ-pic)2(μ-pyO)Ru(κ2-pyO)] (3a) and [PhP(μ-pyO)3Ru(κ2-pyO)] (3b), respectively, were prepared. Reaction of compounds 3 with CO and CNtBu afforded the opening of the Ru(κ2-pyO) chelate motif with the formation of compounds [PhP(μ-pic)2(μ-pyO)Ru(κ-O-pyO)(CO)] (4a), [PhP(μ-pic)2(μ-pyO)2Ru(CNtBu)] (5a), [PhP(μ-pyO)4Ru(CO)] (4b) and [PhP(μ-pyO)4Ru(CNtBu)] (5b). In dichloromethane solution, 4a underwent a reaction with the solvent, i.e., substitution of the dangling pyO ligand by chloride with the formation of [PhP(μ-pic)2(μ-pyO)Ru(Cl)(CO)] (6a). The new complexes 3a, 4a, 5a, 5b and 6a were characterized by single-crystal X-ray diffraction analyses and multi-nuclear (1H, 13C, 31P) NMR spectroscopy. The different coordination behaviors of related pairs of molecules (i.e., pairs of 3, 4 and 5), which depend on the nature of the P–Ru-bridging ligand moieties (μ-pic vs. μ-pyO), were also studied via computational analyses using QTAIM (quantum theory of atoms in molecules) and NBO (natural bond orbital) approaches, as well as the NCI (non-covalent interactions descriptor) for weak intramolecular interactions.
3
Serrano, Mariana P., Claudio D. Borsarelli e Andrés H. Thomas. "Type I Photosensitization of 2′-deoxyadenosine 5′-monophosphate (5′-dAMP) by Biopterin and its Photoproduct Formylpterin". Photochemistry and Photobiology 89, n. 6 (3 agosto 2013): 1456–62. http://dx.doi.org/10.1111/php.12134.
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MURAKAMI, Kazunori, Chris PRIVALLE, Perenlei ENKHBAATAR, Katsumi SHIMODA, Frank C. SCHMALSTIEG, Joseph DEANGELO, Steve LEE, Lillian D. TRABER e Daniel L. TRABER. "Pyridoxalated haemoglobin polyoxyethylene conjugate, a nitric oxide scavenger, decreases dose-limiting hypotension associated with interleukin-2 (IL-2) therapy". Clinical Science 105, n. 5 (1 novembre 2003): 629–35. http://dx.doi.org/10.1042/cs20030164.
Testo completoAbstract (sommario):
Interleukin-2 (IL-2), a cytokine that induces natural killer cells termed lymphokine-activated killer (LAK) cells, is in use as an anticancer agent. During IL-2 therapy, adverse effects, such as vasodilatation and hypotension, are common. Previous studies suggest that these effects are due to nitric oxide (NO). Therefore a model of IL-2-induced hyperdynamic response in sheep was developed to test the effect of pyridoxalated haemoglobin polyoxyethylene conjugate (PHP; a NO scavenger), which is currently in clinical development for the treatment of shock associated with systemic inflammatory response syndrome. Twelve female sheep were divided into four groups (n=3 per group): sham control (Ringer's lactate solution), PHP alone (20 mg·kg-1·h-1 for 96 h), IL-2 alone (recombinant human IL-2; 1440000 units/kg intravenously every 8 h) and a combination of PHP and IL-2. All of the sheep received Ringer's lactate solution to maintain haematocrit at baseline levels. The sheep had free access to food and water. A fall in the mean arterial pressure and systemic vascular resistance index by 20% was observed in the IL-2 group, but not in the PHP+IL-2 group. The fluid requirement to maintain the haematocrit was higher in the IL-2 group (5 ml·kg-1·h-1) than in the PHP+IL-2 group (4 ml·kg-1·h-1). The sham group showed no changes in any of the parameters. Scavenging NO by PHP prevented the hyperdynamic reaction induced by IL-2 administration in sheep. This activity of PHP may prevent the early discontinuation of IL-2 therapy that results because of these adverse events.
5
Sancar, Serpil, e Elif Altınay Kırlı. "Circumcision requirement in children with phimosis: immediately or elective?" Medical Science and Discovery 7, n. 2 (26 febbraio 2020): 425–28. http://dx.doi.org/10.36472/msd.v7i2.357.
Testo completoAbstract (sommario):
Objective: Phimosis is define as unretractable prepuce and has two different clinical presentation; pathological (PaP) and physiological. Physiological phimosis (PhP) is a common condition in children that does not require treatment. In our study, we aimed to determine the actual requirement for circumcision in patients with phimosis who were recommended circumcision.
Material and Methods: Children who were offered circumcision due to phimosis between July 2019 and January 2020 and applied to the pediatric surgery and pediatric urology outpatient clinic were included in the study. They were evaluated in terms of referring physicians, genital examination findings and requirement for circumcision.
Results: Between the study dates, 199 patients applied for circumcision due to phimosis. 126 patients are under one year old, 73 patients are over one year old. PhP was present in 194 of the patients and PaP in 5 of them. While PaP is not detected in patients under one year of age, there are 5 patients with PaP over one year of age (2%). There was no requirement for urgent circumcision in any of the patients. Genital examination revealed incidentally undescended testicle in 3 patients and hydrocele in 12 children.
Conclusion: Male genital system examination and pathological findings are not well known by physicians. We think that there is a need for detailed training for physicians regarding PhP and childhood testicle pathologies.
6
Veelken, Rhea, Bettina Maiwald, Steffen Strocka, Tim-Ole Petersen, Michael Moche, Sebastian Ebel, Timm Denecke et al. "Repeated percutaneous hepatic perfusion with melphalan can maintain long-term response in patients with liver cancers". CardioVascular and Interventional Radiology 45, n. 2 (29 ottobre 2021): 218–22. http://dx.doi.org/10.1007/s00270-021-02983-2.
Testo completoAbstract (sommario):
AbstractChemosaturation (CS; CHEMOSAT®, Delcath Systems Inc.) temporarily administers melphalan into the liver by percutaneous hepatic perfusion (PHP). CS-PHP can effectively control growth in liver tumors, but efficacy and tolerability of sequential treatments are unclear. We analyzed outcomes of sequential CS-PHP treatment. Patients with either unresectable intrahepatic metastases of ocular melanoma (OM, n = 9), cholangiocarcinoma (CCA, n = 3), or hepatocellular carcinoma (HCC, n = 1) were recruited retrospectively. Response was assessed by tomography imaging. Ten patients (mean age 60 years) with more than one CS-PHP treatment were included. CS-PHP was administered 2–6 times in the OM patients, 3 times in the CCA, and the HCC patient received 6 treatments. Overall response rate (ORR) to CS-PHP was 80%, and stable disease was achieved in one patient. Median hepatic progression-free survival (hPFS) was 336 days (range 0–354) for OM, 251 days for the CCA patient, and 256 days for the HCC patient. At the end of observation (153–701 days after first CS-PHP), 6/10 patients were still alive (5/9 with OM, 0 with CCA, and 1 with HCC). Death cases were not related to CS-PHP. Adverse events were mostly hematologic, grade I-IV, and self-resolving. The liver function was not deteriorated by CS-PHP. We conclude that repeated CS-PHP treatments were effective and well tolerated in the long term.
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Schmidpeter, Alfred, e Karl-Heinz Zirzow. "Phosphinocyclopentadienid via Cyclopentadienylphosphid/ Phosphinocyclopentadienide via Cyclopentadienylphosphide". Zeitschrift für Naturforschung B 42, n. 8 (1 agosto 1987): 977–83. http://dx.doi.org/10.1515/znb-1987-0809.
Testo completoAbstract (sommario):
AbstractLithiumorganyls RLi (R = Me, Bu, Ph) add to (PhP)5 in successive degradation and disproportionation equilibria depending on the ratio of the reactants. At -70 °C (R = Me) disproportionation is blocked and (PhP)4R- and (PhP)3R- can be detected. With excess RLi m onophosphides PhPR- are formed. CpNa with the help of a crown ether degrades (PhP)5 or substitutes cyanide from PhPCN- to give an equilibrium mixture of (PhP)nCp- anions, which stabilize by proton shifts: In case of n = 1 and 2 a shift from the Cp unit to the terminal phosphorus results in the formation of the phenylphosphino- and diphenyldiphosphino-cyclopentadienide anion, in case of n = 3 two proton shifts within the Cp unit result in a cyclopenteno-l,2,3-triphospholene allylic anion.
8
Borm, Jutta, Gottfried Huttner, Olli Orama e Laszlo Zsolnai. "Reaktionen des diphosphen-komplexes (CO)5CrPhPPPhCr(CO)5". Journal of Organometallic Chemistry 282, n. 1 (febbraio 1985): 53–67. http://dx.doi.org/10.1016/0022-328x(85)87141-2.
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Roesky, Herbert W., Kaveripatnam S. Dhathathreyan, Mathias Noltemeyer e George M. Sheldrick. "Reactions of the Hexafluorothioacetone Dimer with Cyanides of Phosphorus, Arsenic and Germanium". Zeitschrift für Naturforschung B 40, n. 2 (1 febbraio 1985): 240–46. http://dx.doi.org/10.1515/znb-1985-0216.
Testo completoAbstract (sommario):
Abstract Cyanides such as P(CN)3 , As(CN)3 , PhP(CN)2 , ButAs(CN)2 and Ge(CN)4 react with [(CF3)2CS]2 (1) by insertion of the carbon atom of the iso-nitrile isomer into the four-membered [CS]2 ring to give compounds PR′3 (2), AsR′3 (3), FP(S)R′2 (4), PhP(S)R′2 (5), ButAsR′2 (6) and GeR′4 (7) respectively, where R′ is the novel heterocyclic ligand[xxx]. The crystal structures of 3 and 7 are reported.
10
Bone, Hans G., Paul J. Schenarts, Stefanie R. Fischer, Roy McGuire, Lillian D. Traber e Daniel L. Traber. "Pyridoxalated hemoglobin polyoxyethylene conjugate reverses hyperdynamic circulation in septic sheep". Journal of Applied Physiology 84, n. 6 (1 giugno 1998): 1991–99. http://dx.doi.org/10.1152/jappl.1998.84.6.1991.
Testo completoAbstract (sommario):
We investigated the effects of modified hemoglobin on regional blood flow and function of different organs during hyperdynamic sepsis. Fourteen sheep were surgically prepared for the study. After a 5-day recovery period, a continuous infusion of live Pseudomonas aeruginosa bacteria was begun and maintained for 48 h. At 24 h, after a hyperdynamic circulation had developed, the animals were randomly assigned to two groups: 1) a treatment group ( n = 7) that received an infusion with 100 mg/kg pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) over 30 min and 2) a control group ( n = 7) that received only the vehicle. PHP infusion increased mean arterial pressure from 86 ± 2.8 to 101.8 ± 3.5 mmHg ( P < 0.05) and systemic vascular resistance index from 769 ± 42.1 to 1,087 ± 56.8 dyn ⋅ s ⋅ m2⋅ cm−5( P < 0.05). PHP infusion did not decrease regional blood flow, measured with fluorescent microspheres, below the baseline values in any of the analyzed tissues. None of the investigated blood chemistry variables showed any changes indicative of impaired organ function after PHP infusion. In our model of ovine sepsis we found no side effects after PHP infusion that would limit the use of PHP as a nitric oxide scavenger in sepsis.
11
Qi, Zijuan, Zhensheng Li, Quwen Gao, Li Dong, Jian Lin, Kairun Peng, Wei Xiang e Bingmei Deng. "Characterizing Cerebral Imaging and Electroclinical Features of Five Pseudohypoparathyroidism Cases Presenting with Epileptic Seizures". Behavioural Neurology 2022 (12 agosto 2022): 1–7. http://dx.doi.org/10.1155/2022/8710989.
Testo completoAbstract (sommario):
Objective. To characterize the cerebral imaging and electroclinical features and investigate their etiological contributions to seizures in pseudoparathyroidism (PHP). Methods. The clinical symptoms, biochemical imaging by magnetic resonance imaging (MRI) and computed tomography (CT) tests, and electroencephalogram (EEG) manifestations of five PHP patients with seizures were retrospectively collected and analyzed. Results. Physical examination showed an average stature in cases 2~4 and short stature in cases 1 and 5. X-ray tests suggested ectopic calcification in four patients. The seizures in four cases were effectively controlled with antiseizure medicines (ASMs). Cerebral CT scans showed extensive brain calcifications in the bilateral basal ganglia (all five cases), cerebellum (cases 1, 3, and 5), thalamus (case 4), and cerebral cortex. Cerebral MRI showed short T1 signals mainly in the basal ganglia. EEG records revealed focal EEG abnormalities, including abnormal slow waves and epileptiform discharges, mainly over the temporal and frontal lobes. The brain areas with focal EEG abnormalities and calcification did not always coincide. Conclusion. The seizures in PHP can be focal to bilateral tonic–clonic. ASMs are effective in epilepsy combined with PHP. Intracranial calcification is not a reliable etiological cause of epilepsy in PHP patients.
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Dewald, C. L. A., L. S. Becker, S. K. Maschke, T. C. Meine, T. A. Alten, M. M. Kirstein, A. Vogel, F. K. Wacker, B. C. Meyer e J. B. Hinrichs. "Percutaneous isolated hepatic perfusion (chemosaturation) with melphalan following right hemihepatectomy in patients with cholangiocarcinoma and metastatic uveal melanoma: peri- and post-interventional adverse events and therapy response compared to a matched group without prior liver surgery". Clinical & Experimental Metastasis 37, n. 6 (9 ottobre 2020): 683–92. http://dx.doi.org/10.1007/s10585-020-10057-9.
Testo completoAbstract (sommario):
AbstractTo evaluate feasibility, frequency and severity of peri-procedural complications and post-procedural adverse events (AEs) in patients with advanced cholangiocarcinoma or liver metastasis of uveal melanoma and prior hemihepatectomy undergoing chemosaturation percutaneous hepatic perfusion (CS-PHP) and to analyze therapy response and overall survival compared to a matched group without prior surgery. CS-PHP performed between 10/2014 and 02/2018 were retrospectively assessed. To determine peri-procedural safety and post-procedural adverse events, hospital records and hematological, hepatic and biliary function were categorized using Common Terminology Criteria for Adverse Events (CTCAE) v5.0 (1–5; mild-death). Significance was tested using Wilcoxon signed-rank and Mann–Whitney U test. Kaplan–Meier estimation and log-rank test assessed survival. Overall 21 CS-PHP in seven patients (4/7 males; 52 ± 10 years) with hemihepatectomy (grouphemihep) and 22 CS-PHP in seven patients (3/7 males; 63 ± 12 years) without prior surgery (groupnoresection) were included. No complications occurred during the CS-PHP procedures. Transient changes (CTCAE grade 1–2) of liver enzymes and blood cells followed all procedures. In comparison, grouphemihep presented slightly more AEs grade 3–4 (e.g. thrombocytopenia in 57% (12/21) vs. 41% (9/22; p = 0.37)) 5–7 days after CS-PHP. These AEs were self-limiting or responsive to treatment (insignificant difference of pre-interventional to 21–45 days post-interventional values (p > 0.05)). One patient in grouphemihep with high tumor burden died eight days following CS-PHP. No deaths occurred in groupnoresection. In comparison, overall survival after first diagnosis was insignificantly shorter in groupnoresection (44.7(32–56.1) months) than in grouphemihep (48.3(34.6–72.8) months; p = 0.48). The severity of adverse events following CS-PHP in patients after hemihepatectomy was comparable to a matched group without prior liver surgery. Thus, the performance of CS-PHP is not substantially compromised by a prior hemihepatectomy.
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Brüning, R., M. Tiede, M. Schneider, P. Wohlmuth, H. Weilert, K. Oldhafer e A. Stang. "Unresectable Hepatic Metastasis of Uveal Melanoma: Hepatic Chemosaturation with High-Dose Melphalan—Long-Term Overall Survival Negatively Correlates with Tumor Burden". Radiology Research and Practice 2020 (2 settembre 2020): 1–7. http://dx.doi.org/10.1155/2020/5672048.
Testo completoAbstract (sommario):
Introduction. Percutaneous hepatic perfusion with melphalan (PHP-M) for hepatic metastasis of uveal melanoma (LMUM) achieves high local response rates, but the individual clinical benefit is poorly defined. We aimed to determine cofactors of response and clinical outcomes including the probability of long-term (5-years) overall survival (OS) in PHP-M-treated patients with LMUM. Patients and Methods. We retrospectively reviewed clinicopathological, radiological, and outcome data of 19 patients with unresectable LMUM treated with 43 PHP-M (median 2 PHP-M) between 2014 and 2019. Tumor response and adverse events were evaluated using RECIST 1.1 and the Clavien–Dindo classification. Kaplan–Meier methods and Cox regression hazard proportional models were used. Results. Of 19 patients, 10 (53%) achieved a partial response (PR) and 9 (47%) had stable disease (SD). There was no progressive disease (PD) and no adverse events exceeding Clavien–Dindo grade IV. Median OS was 16.7 months after the first PHP-M treatment and 26.4 months after initial diagnosis. Low hepatic tumor volume (median of 10 mL vs. 150 mL) was an independent predictor of favorable OS (hazard ratio (95% confidence interval): 0.190 (0.041, 0.893); p<0.05), and female patients were at a lower risk compared with males (0.146 (0.017, 1.240)). Estimates of the overall survival were 0.213 (0.0449, 1) from first imaging (95% confidence interval) to 5 years and 0.793 (0.609, 1) and 0.604 (0.380, 0.960) for 1 and 2 years after chemosaturation, respectively. Discussion. PHP-M for nonresectable LMUV provides a safe and locally efficient liver-directed procedure that offers patients a chance for long-term OS, especially for patients with a low hepatic tumor burden.
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Gill, Christopher. "Galen and the Stoics: Mortal Enemies or Blood Brothers?" Phronesis 52, n. 1 (2007): 88–120. http://dx.doi.org/10.1163/156852807x177977.
Testo completoAbstract (sommario):
AbstractGalen is well known as a critic of Stoicism, mainly for his massive attack on Stoic (or at least, Chrysippean) psychology in On the Doctrines of Hippocrates and Plato (PHP) 2-5. Galen attacks both Chrysippus' location of the ruling part of the psyche in the heart and his unified or monistic picture of human psychology. However, if we consider Galen's thought more broadly, this has a good deal in common with Stoicism, including a (largely) physicalist conception of psychology and a strongly teleological view of natural entities, shared features which are acknowledged in several treatises outside PHP. Why, then, is Galen such a remorseless and negative critic of Stoicism in PHP? Various factors are relevant, including the shaping influence on Galen of the Platonic-Aristotelian (part-based) psychological framework. But, it is suggested here, an important underlying factor is the contrast between two ways of thinking about the part-whole relationship, a 'composition' and a 'structure' approach or an atomistic and holistic approach. This contrast is most evident and explicit in one section of PHP 5, where Galen, criticising Chrysippus' holistic psychology, denies that the Stoic thinker is entitled to use the concept of part at all. But the contrast is also seen as pervading Galen's response to Stoic thought more generally, in PHP and elsewhere, in ways that inform his explicit disagreements with Stoic theory. Stoicism is presented here as having a consistently 'structure' (or holistic) approach. Galen's approach is seen as more mixed, sometimes sharing, or aspiring towards, a holistic picture, and yet sometimes (especially in PHP 5), adopting a strongly 'composition' or atomistic standpoint. This (partial) contrast in conceptual frameworks is presented as offering a new perspective on Galen's critique of Stoic psychology in PHP and on his relationship to Stoic thought more generally.
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Wittern, Ursula, Joachim Strähle e Ulrich Abram. "Synthese von Nitrenkomplexen mit N-Trimethylsilylanilin I. Charakterisierung und Kristallstruktur von [Re(NPh)Cl3(Et2PhP)2] und [Re(NPh)Cl3(Ph3P)2] ·1/2 CHCl3 / Synthesis of Nitrene Complexes with N –T rimethylsilylaniline I. Characterisation and Crystal Structure of [Re(NPh)Cl3(Et2PhP)2] and [Re(N Ph)Cl3(Ph3P)2] · 1/2CHCl3". Zeitschrift für Naturforschung B 50, n. 7 (1 luglio 1995): 997–1003. http://dx.doi.org/10.1515/znb-1995-0702.
Testo completoAbstract (sommario):
trans-mer--Trichlorobis(diethylphenylphosphine)phenylnitrene rhenium(V), [Re(NPh)Cl3- (Et2PhP)2], has been synthesized from [ReOCl3 (Et2 PhP)2 ] and N-trimethylsilylaniline, while trans-mer-trichlorophenylnitrenebis (triphenylphosphine) rhenium(V), [Re(NPh)Cl3 (Ph3P)2] has been obtained via a novel route, from (Bu4N)[ReOCl4 ] and N-trimethylsilylanilin. The products were studied by mass spectrometry, IR spectroscopy and X-ray diffraction.trans-mer-[Re(NPh)Cl3(Et2PhP)2 ] crystallizes in the monoclinic space group P21/n with a = 1498.5(3), b = 1068.6(1), c = 1784.0(4) pm and β = 91.28(1)°, Z = 4. The rhenium atom exhibits a distorted octahedral coordination with the phosphine groups in trans positions, and the Cl ligands in a meridional arrangement. The Re ≡N -C moiety is linear with a bond angle o f 169,4(5)°and a Re= N bond length o f 171.8(6) pm.[Re(NPh)Cl3(Ph3P)2 ]· 0.5 CHCI3 crystallizes in the triclinic space group P 1̄ with a = 1232.1 (4), b= 1431.6(5), c = 2236.6(8) pm, a = 89.19(2)°, β = 80.50(2)°and γ = 88.26(2)°, Z = 4. The asymmetric unit contains two symmetry independent complex molecules of approximately the same structure, with Cl atoms meridionally arranged and the phosphine groups in trans positions. The coordination geometry is a distorted octahedron. The almost linear Re≡N -C moieties have Re≡N bond lengths of 170.2(7) and 170.8(7) pm, respectively, and Re≡N -C angles of 173.3(6)°and 175.0(7)°.
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Anderson, Gordon K., e Minren Lin. "Preparation of Ph2PC5H4− and PhP(C5H4)2−bridged zirconium(IV)-platinum(II) complexes". Inorganica Chimica Acta 142, n. 1 (febbraio 1988): 7–8. http://dx.doi.org/10.1016/s0020-1693(00)80646-5.
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Zirzow, Karl-Heinz, e Alfred Schmidpeter. "Tetraphospholan-Bildung via Phosphaalken durch LiSnPh3-katalysierte PhP-Übertragung / Formation of a Tetraphospholane via Phosphaalkene by LiSnPh3-Catalyzed Transfer of PhP Units". Zeitschrift für Naturforschung B 43, n. 11 (1 novembre 1988): 1475–77. http://dx.doi.org/10.1515/znb-1988-1113.
Testo completoAbstract (sommario):
Abstract Lithium triphenylsilyl-phenylphosphide (3), X = SiPh3 , reacts with ketones to give tetraphenyl-phospholanes (6). In an initial step a phosphaalkene 5 is formed, which then adds three more phenylphosphinidene units. This second step can be performed independently, and the PhP units can be furnished by pentaphenylcyclopentaphosphane (1) if the reaction is catalyzed by lithium triphenylstannide (2), X = SnPh3.
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Boota, Muhammad, Syed Muhammad Ali Shah, Abid Rashid, Muhammad Akram, Sultan Ayaz, Imtiaz Mustafa, Jaweria Nisar e Zonaira Nisar. "The Hepatoprotective and Anti-Nephrotoxic Potential of Methanolic Extract of a Polyherbal Preparation in CCl4-Induced Liver Injury Model of Wistar Rats". Dose-Response 20, n. 3 (luglio 2022): 155932582211247. http://dx.doi.org/10.1177/15593258221124728.
Testo completoAbstract (sommario):
The liver and kidneys are the vital organs of the body and perform important life-sustaining functions in the body. Synthetic drugs used in the treatment of liver and kidney diseases are sometimes inadequate and can lead to serious side effects. Medicinal herbs and plants were used to combat diseases for a long time and combination therapy is preferred over single plant therapy. In the current study, the Asparagus racemosus, Mucuna pruriens, Anacyclus pyrethrum, and Tribulus terrestris polyherbal preparation (PHP) was selected to evaluate its hepatoprotective, antioxidant, and anti-nephrotoxic potential. The methanolic extract of PHP was prepared following standard protocols. Fifty-six albino rats were divided into 7 groups (n = 8). The negative control (NC) having the healthy rats and the remaining 6 groups were induced liver toxicity by intraperitoneally injecting 0.5 mL/kg of 50% CCl4 in olive oil. Group 2 was positive control and group 3 and 4 received silymarin standard drug at the dose of 100 and 200 mg/kg body weight. Groups 5, 6, and 7 (PHP-1, PHP-2, PHP-3) were the liver-damaged rats receiving the PHP at a dose of 50, 100, and 150 mg/kg body weight. Blood samples were collected at 21 of the trial, to evaluate oxidative stress, hepatoprotective and anti-nephrotoxic potential. Results of liver function tests revealed significant ( P < .05) hepatoprotective activities of PHP after intoxication with CCl4 of albino rats as compared to standard groups. Moreover, results of renal functions also showed that PHP has a significant ( P < .05) restoring the capacity of blood urea, creatinine, and uric acid in intoxicated rats as compared with the control group. The PHP also reduced the oxidative stress in the treatment groups by increasing the total antioxidant capacity and reducing the total oxidative status. It can be concluded that selected medicinal plants have a potential role in the management of liver and kidney disorders. So, by running the clinical trial on a large scale and by isolating the phytochemical constituents responsible for hepatoprotective and nephroprotective activities, locally prepared drugs could be developed to manage liver and renal disorders.
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Bugi, Valentina S. L. S., e Simon Ruruk. "PERAN KALIMAT DEPONEN BAHASA INDONESIA DALAM NOVEL GILA PHP KARYA JACOB JULIAN". Mataallo : Masyarakat Peneliti Pendidikan Bahasa Indonesia 1, n. 2 (7 settembre 2021): 9–16. http://dx.doi.org/10.47178/mataallo.v1i2.1327.
Testo completoAbstract (sommario):
Penelitian ini bertujuan untuk mendeskripsikan peran kalimat deponen dalam novel Gila PHP karya Jacob Julian. Jenis penelitian ini adalah penelitian kualitatif. Data penelitian berupa kalimat-kalimat deponen yang terdapat dalam novel Gila PHP karya Jacob Julian. Populasi dalam penelitian ini adalah 58 kalimat deponen, sedangkan sampel dalam penelitian ini ada 39 kalimat deponen. Teknik yang penulis gunakan untuk memperoleh data yakni (1) teknik baca, yaitu teknik yang digunakan untuk mengamati objek yang dibaca secara kritis, (2) teknik catat, yaitu teknik yang digunakan untuk mencatat data atau apa yang dilihat atau yang ditemukan yang dianggap memenuhi syarat. Berdasarkan hasil penelitian dapat disimpulkan, yaitu (1) Peran Pelaku - Perbuatan, (2) Peran Pelaku - Perbuatan - Sasaran, (3) Peran Pelaku - Perbuatan - cara, (4) Peran Pelaku - Perbuatan - Tempat, (5) Peran Pelaku - Perbuatan - Sasaran - Waktu.
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Carsote, Mara, Mihaela Stanciu, Florina Ligia Popa, Ana-Maria Gheorghe, Adrian Ciuche e Claudiu Nistor. "Pediatric Neuroendocrine Neoplasia of the Parathyroid Glands: Delving into Primary Hyperparathyroidism". Biomedicines 11, n. 10 (17 ottobre 2023): 2810. http://dx.doi.org/10.3390/biomedicines11102810.
Testo completoAbstract (sommario):
Our objective was to overview the most recent data on primary hyperparathyroidism (PHP) in children and teenagers from a multidisciplinary perspective. Methods: narrative review based on full-length, English-language papers (from PubMed, between January 2020 and July 2023). Results: 48 papers (14 studies of ≥10 subjects/study, and 34 case reports/series of <10 patients/study). Study-sample-based analysis: except for one case–control study, all of the studies were retrospective, representing both multicenter (n = 5) and single-center (n = 7) studies, and cohort sizes varied from small (N = 10 to 19), to medium-sized (N = 23 to 36) and large (N = 63 to 83); in total, the reviewed studies covered 493 individuals with PHP. Case reports/series (n = 34, N = 41): the mean ages studied varied from 10.2 to 14 years in case reports, and the mean age was 17 years in case series. No clear female predominance was identified, unlike that observed in the adult population. Concerning the assessments, there were four major types of endpoints: imaging data collection, such as ultrasound, 99mTc Sestamibi, or dual-phase computed tomography (CT); gene testing/familial syndrome identification; preoperative findings; and exposure to surgical outcome/preoperative drugs, like cinacalcet, over a 2.2-year median (plus two case reports of denosumab used as an off-label calcium-lowering agent). Single-gland cases (representing 85% of sporadic cases and 19% of genetic PHP cases) showed 100% sensitivity for neck ultrasounds, with 98% concordance with 99mTc Sestamibi, as well as a 91% sensitivity for dual-phase CT, with 25% of the lesions being ectopic parathyroids (mostly mediastinal intra-thymic). Case reports included another 9/41 patients with ectopic parathyroid adenomas, 3/41 with parathyroid carcinomas, and 8/41 subjects with brown tumors. Genetic PHP (which has a prevalence of 5–26.9%) mostly involved MEN1, followed by CDC73, CASR, RET, and CDKN1B, as well as one case of VHL. Symptomatic PHP: 70–100% of all cases. Asymptomatic PHP: 60% of genetic PHP cases. Renal involvement: 10.5% of a cohort with genetic PHP, 71% of sporadic PHP cases; 50% (in a cohort with a mean age of 16.7), 29% (in a cohort with a mean age of 15.2); 0% (in infancy) to 50–62% (in teenagers). Bone anomalies: 83% of the children in one study and 62% of those in two other studies. Gastrointestinal issues: 40% of one cohort, but the data are heterogeneous. Cure rate through parathyroidectomy: 97–98%. Recurrent PHP: 2% of sporadic PHP cases and 38% of familial PHP cases. Hungry bone syndrome: maximum rate of 34–40%. Case reports identified another 7/41 subjects with the same post-parathyroidectomy condition; a potential connection with ectopic presentation or brown tumors is suggested, but there are limited data. Minimally invasive thoracoscopic approaches for ectopic tumors seemed safe. The current level of statistical evidence on pediatric PHP qualifies our study- and case-sample-based analysis (n = 48, N = 534) as one of the largest of its kind. Awareness of PHP is the key factor to benefit our young patients.
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Lisbeth Siahaan, Yenny, Sekar Restuning, Ni Made Yuliana e Jendri Mamangkey. "Improving Maternal Role on Toddler Oral Hygiene in Integrated Service Center (Posyandu) Beber, Cirebon, Indonesia through Participatory Approach Assistance". International Journal of Health and Pharmaceutical (IJHP) 1, n. 1 (9 novembre 2021): 27–35. http://dx.doi.org/10.51601/ijhp.v1i1.5.
Testo completoAbstract (sommario):
Poor dental health on children including caries causes pain and difficulty in chewing. This study aimed to analyze the effect of assistance model on mothers to impove toddler oral health aged 2-5 years old. This research employed quasi-experiment through pretest and posttest approach intervention. The samples were mothers having 2-5 years old toddlers who met inclusion criteria including having PHP-M teeth index score of 40, willing to be involved, the mothers have at least junior high school education level and living in the Posyandu are. Meanwhile, the exclusion criteria was mothers who rarely visited Posyandu. Furthermore, data were analyzed using univariate and bivariate. If the data were not normally distributed, then Wilcoxon test would be done. Difference obtained between before and after the assistance model was provided to the mothers with significance value of p=0.001 (p<0.05). This indicates that assistance model caused changes on mothers’ knowledge at Posyandu. Same results were obtained from attitude, skills and PHP-M index score before and after the intervention with significance value of P=0.001 (p<0.05). This shows that assistance model caused changes on attitude, skills and decrease of toddlers’ PHP-M index score at Posyandu Beber. The outcome of the current research obtained that assistance model is proven to be more effective in improving toddler oral hygiene than extension that was carried out at Posyandu.
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Tong, Thaïs M. L., Mark C. Burgmans, Frank M. Speetjens, Arian R. van Erkel, Rutger W. van der Meer, Carla S. P. van Rijswijk, Mare A. Jonker et al. "Safety and efficacy of combined melphalan percutaneous hepatic perfusion (M-PHP) and ipilimumab plus nivolumab (IPI+NIVO) in metastasized uveal melanoma (mUM): First results of the phase Ib part of the CHOPIN trial." Journal of Clinical Oncology 40, n. 16_suppl (1 giugno 2022): 9560. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.9560.
Testo completoAbstract (sommario):
9560 Background: Uveal melanoma (UM) is the most frequent intraocular malignant tumor in adults. Approximately 50% of all patients (pts) will develop metastatic disease in the liver. Until now, there is no systemic therapy that has been shown to improve overall survival (OS), apart from tebentafusp. M-PHP is frequently applied for liver-only UM. However, the majority of pts eventually develops extrahepatic disease after M-PHP. IPI+NIVO has been shown to induce up to 20% response rates in mUM. Our observations that checkpoint inhibition was most effective on extrahepatic UM disease has led to the CHOPIN trial testing the combination of M-PHP and IPI+NIVO. Here we present the safety and efficacy data of the phase 1b part of CHOPIN. Methods: Adult pts with confirmed measurable hepatic mUM and WHO PS 0-1 were included. Two courses of 6 weekly M-PHPs (melphalan 3mg/kg, max 220mg) were combined with four courses IPI+NIVO three-weekly escalating the dosing from 1mg/kg each IPI+NIVO (cohort 1) to IPI 1mg/kg + NIVO 3mg/kg (cohort 2). Primary endpoint was safety of IPI+NIVO plus M-PHP. Secondary endpoints were best overall response (BOR) according to RECIST 1.1, progression-free survival (PFS), and OS. Results: 7 pts were included (4 male, median age 63.6 years (range 50-74)). Both cohorts were tolerated with no dose-limiting toxicities or deaths. Grade III/IV adverse events (AE) were observed in 2/3 pts in cohort 1 and in 3/4 pts in cohort 2 consisting of SIRS, febrile neutropenia, cholecystitis, neutropenia, thrombopenia, leukopenia, increased transaminases and fever. Grade I/II immune-related AEs occurred in all pts (myositis, hypothyroidism, hepatitis and dermatitis). BOR was 1 complete response, 5 partial responses and 1 stable disease accounting for an objective response rate (ORR) of 85.7%. At a median FU time of 20.2 months, 4 pts have an ongoing response. Currently the median PFS is 22.4 months, and all pts are still alive. Conclusions: Combining M-PHP with IPI+NIVO is safe at a dosing of IPI 1 mg/kg and NIVO 3 mg/kg and very promising ORR, PFS and OS have been observed. The randomized phase II part comparing M-PHP versus M-PHP+IPI+NIVO is currently recruiting. Clinical trial information: NCT04283890.
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Colvin-Wanshura, Leah E., Matthew S. Nelson, Elliot J. Stephenson, Shaukat A. Khan, Yonghong Xie e Pankaj Gupta. "Selective Modulation of the BMP Signaling Pathway Has Distinct Effects on Long-Term In Vitro Maintenance of Primitive Hematopoietic Progenitors in Human Umbilical Cord Blood." Blood 106, n. 11 (16 novembre 2005): 3162. http://dx.doi.org/10.1182/blood.v106.11.3162.3162.
Testo completoAbstract (sommario):
Abstract Factors responsible for long-term survival and proliferation of human hematopoietic stem cells (hHSC), and their mechanisms of action, remain to be defined. We previously showed that specific O-sulfated heparan sulfate (OS-HS) improves human long-term culture initiating cell (LTC-IC) maintenance for up to 5 wks in vitro. This is related to the ability of OS-HS to bind to and modulate the activity of heparin-binding cytokines on primitive hematopoietic progenitors (PHP). Recent studies indicate that bone morphogenetic proteins (BMPs) influence the development of embryonic hematopoiesis and also augment short-term survival and proliferation of hHSC. Since HS may modulate BMP activity, we examined how combinations of OS-HS, BMPs and specific BMP antagonists influence PHP in umbilical cord blood (UCB). First, we confirmed by real-time quantitative RT-PCR (qRT-PCR) that UCB CD34+ and/or CD34+/CD38− cells (using linear mRNA amplification) constitutively express transcripts for BMP-4 and its inhibitor Chordin, BMP receptors BMPR-IA, BMPR-IB, BMPR-II, AcvR-II and AcvR-IIB, downstream signaling proteins SMAD-1 and -5, and target genes upregulated by BMPs including Inhibitors of DNA binding (Id) proteins 1–4, and determined their relative levels of expression. BMP-4 upregulated Id2 expression 17-fold, confirming that the BMP signaling pathway is functionally active in CD34+ cells. Next, we demonstrated that OS-HS may protect BMP-4 from its inhibitors, using Western immunoblotting of immunoprecipitated proteins to show that direct binding of the antagonist Chordin to BMP-4 is inhibited by OS-HS in a dose-dependent manner. Finally, we examined the effect of exogenous supplementation with 6 BMPs, or inhibition of endogenous BMPs by 7 antagonists, on short-term (2 wk) and long-term (5 wk) LTC-IC maintenance in UCB CD34+/CD38− cells cultured in presence of OS-HS, Flt3-ligand and thrombopoietin. Long-term LTC-IC maintenance was enhanced by BMP-4 (LTC-IC maintenance: 164 +/− 11% compared to culture without BMP-4; P=0.0001) but reduced by BMP-2 or BMP-7 (P<0.005), whereas BMP-3 had no effect. In combination, BMP-3, -4 and -7 offset each other, with no net effect on LTC-IC maintenance. The simultaneous presence of BMPs 2–7 was markedly inhibitory to both short-term (56 +/− 11%; P=0.0018) and long-term (38 +/− 11%; P=0.0024) LTC-IC maintenance. Inhibition of endogenous BMPs by Noggin (which antagonizes BMP-2, -4 and -7 and GDF-5) most effectively enhanced long-term LTC-IC maintenance (320 +/− 36%; P=0.0002). In contrast, other antagonists that inhibit different groups of BMPs did not enhance long-term LTC-IC maintenance. These results indicate that (a) the BMP signaling pathway is expressed and functionally active in human PHP, (b) different members of the BMP family have distinct stimulatory or inhibitory effects on long-term LTC-IC maintenance, (c) endogenously expressed BMPs are extremely important modulators of long-term PHP maintenance, and (d) the ability of OS-HS to augment long-term in vitro PHP maintenance may be related to its effect on endogenous BMP activity. Our data suggest that selective modulation of BMP signaling may be essential for achieving long-term in vitro maintenance of human PHP. Ongoing studies are investigating how OS-HS affects BMP signaling, and the downstream effects of these molecules on target genes that influence stem cell decisions and fate.
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Güner, Savaş, Bahri Bozgeyik, Kamil İnce, Orhan Büyükbebeci e Burçin Karslı. "A Comparative Study of Trochanteric Fractures Treated with Hip Hemiarthroplasty or Proximal Femoral Nail — A Secondary Publication". Bone and Arthrosurgery Science 2, n. 2 (7 giugno 2024): 35–42. http://dx.doi.org/10.26689/bas.v2i2.7037.
Testo completoAbstract (sommario):
Objective: The aim of this study was to compare the clinical and functional outcomes of patients treated with partial hip prosthesis (PHP) or double lag screw proximal femoral nailing (PFN) for unstable femoral intertrochanteric region fractures. Material and method: In this study, the data of 101 patients who developed grade 3-4-5 femoral intertrochanteric fractures according to the Evans-Jensen classification between 2019–2020 and were treated with cemented PHP or double screw PFN were evaluated retrospectively. The patients were evaluated in terms of postoperative follow-up time, age, gender, trauma side, American Anesthesia Society Anesthesia Risk Scale (ASA), number of comorbid diseases, total hospitalization time, amount of intraoperative bleeding, duration of surgery, and postoperative complications. Results: 101 patients evaluated within the scope of the study were divided into groups of 51 patients who underwent PHP (Group 1) and 50 patients who underwent PFN (Group 2). When the results were compared in terms of mean length of hospital stay, duration of surgery, amount of intraoperative bleeding, and postoperative 1-year mortality, the results were found to be statistically significant. Conclusion: Our study results showed that the PFN method has clinical advantages over PHP. The PFN technique is a method that can be applied quickly and safely.
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Makazan, Nadezhda V., Elizaveta M. Orlova, Elena V. Tozliyan, Maria A. Melikyan, Maria A. Kareva, Natalia Yu Kalinchenko e Valentina A. Peterkova. "Variable phenotype of pseudohypoparathyroidism in children". Problems of Endocrinology 63, n. 3 (15 giugno 2017): 148–61. http://dx.doi.org/10.14341/probl2017633148-161.
Testo completoAbstract (sommario):
Background. Pseudohypoparathyroidism (PHP) is a heterogeneous group of disorders associated with tissue insensitivity to parathyroid hormone. PHP is characterized by genetic heterogeneity and variable phenotype. In addition to the hypocalcemic syndrome and resistance to parathyroid hormone, PHP is also characterized by phenotypic features and resistance to other hormones (TSH, LH, FSH, and GHRH), which are known as Albright Hereditary Osteodystrophy (AHO). Until recently, no analysis of large cohorts of patients with PHP has been performed in Russian literature.
Objective — to examine a large cohort of patients with PHP and assess the clinical features of PHP.
Material and methods. A group consisting of 32 patients with different variants of course of the disease who had been examined at the Endocrinology Research Center in 2014—2016 was analyzed.
Results. Features of AHO phenotype in addition to hormonal resistance were identified in 16 (50%) patients; one of them had one feature (brachydactyly) and 15 patients had two and more features of AHO. Besides insensitivity to PTH, TSH resistance was found in 22 (68.75%) patients and one patient had resistance to PTH, TSH and LH/FSH. Hypothyroidism manifested before hypocalcaemia in 4 patients. Obesity was the first complaint in 8 patients; 5 of them had subclinical hypocalcaemia and the remaining 3 patients had an elevated PTH level with the normal level of calcium at the time of first examination. The most typical clinical signs of hypocalcaemia in 23 (72%) patients were seizures. Thirteen of them were misdiagnosed with epilepsy and had been followed by a neurologist for a period ranging between 2 months and 7 years before hypocalcaemia was revealed.
Conclusions. Pseudohypoparathyroidism is a rare genetic disorder associated with resistance to parathyroid hormone, which can have a lot of other clinical features in addition to the symptoms of PTH resistance. Obesity or hypothyroidism can be the earliest manifestation of PHP preceding hypocalcaemia. Evaluation of serum calcium level is important for all pediatric patients with seizures to timely diagnose hypocalcaemia and avoid misdiagnosing.
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Algburi, Dr Abbas K. "Continuous Separation Process of Water-in-Crude Oil Emulsion by Simultaneous Application of an Electrical Field Combined with a Novel Absorbent Based on Functionalised PolyHIPE Polymer". Journal of Petroleum Research and Studies 11, n. 4 (20 dicembre 2021): 91–113. http://dx.doi.org/10.52716/jprs.v11i4.565.
Testo completoAbstract (sommario):
During the extraction process of crude oil, the removal of water from a high stability water-in-crude oil emulsions is life-threatening for the production of a profitable product. However, several technologies of separation exist today, e.g. stripping columns, centrifugal separators, coalescence separators, vacuum distillation systems and gravity separators, almost all of these approaches are not able to completely remove water from water-in-crude oil emulsions besides their high cost.
In this study, the preparation of a high internal phase emulsion (HIPE) was achieved on a laboratory scale. Subsequently, it was polymerized and sulphonated to produce a hydrophilic macroporous polyHIPE polymer (PHP) called silane (vinyl trimethoxy silane) PHP with a relatively high surface area of 104 m 2/g. It demonstrates high water absorption capability in addition to its ability to remove surface active substances such as Mg, Ca, Na and Cl, from crude oil which cause crude oil emulsification.
The rates of demulsification of water-in-crude oil emulsions were examined in high AC field under various emulsion inlet flow rates from 100 ml/min to 1500 ml/min and different applied voltages from 1-5 kV (equivalent to 14-69 kV/m) by using a model of an electrostatic separator combined with silane PHP as absorber. It was found that the best separation efficiency was 91% with applied voltage of 5 kV and emulsion inlet flow rate of 100 ml/min. When the spent silane PHP was reused in the demulsification process under similar conditions, a separation efficiency of up to 73% was achieved. Also, it was noticed that the separation efficiency was increased with the increase in applied voltage and reduction in the inlet flow rate of emulsion. Moreover, the original or spent silane PHP were able to remove the undesired metals present in the crude oil.
Keywords: Demulsification; Emulsion flow rate; Separation efficiency; Electrostatic Separator; Electric field strength.
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Dotollo, Michael, e Ulysses Cagasan. "Performance of Hybrid Lowland Rice (Oryza sativa L. var. SL-12H) to Application of Plant Growth Regulators and Inorganic Fertilizer". Science and Humanities Journal 16, n. 1 (27 dicembre 2022): 47–57. http://dx.doi.org/10.47773/shj.1998.161.4.
Testo completoAbstract (sommario):
Plant growth regulators (PGR) enhance the growth and yield of rice. This study aimed to determine the effects of growth regulators on the growth and yield of hybrid lowland rice, determine the kind of growth regulators and their appropriate concentrations that would give the optimum yield of hybrid lowland rice, and evaluate the profitability of rice production per hectare using the different plant growth regulators applied to hybrid lowland rice. The experimental area was laid out in Randomized Complete Block Design (RCBD) with three replications. The treatments were T = control, T = 500 ppm PBZ + RR, T = 1000 ppm PBZ + RR, T = 0 1 2 3 500 ppm PBZ + 500 ppm ANAA + RR, T = 500 ppm ANAA + RR, T = 1000 ppm ANAA 4 5 + RR, and T =120-60-60 kg ha-1 N, P O K O [RR]). Results revealed that the 6 2 5, 2 application of plant growth regulators significantly affected the agronomic characteristics of hybrid lowland rice. Rice plants applied with paclobutrazol regardless of the level (T and T ) and unfertilized plants (T ) headed and matured 1 2 0 earlier than the other treatments. The application of PBZ and NAA regardless of the concentration (T -T ) significantly did not vary in all the yield components of hybrid 1 5 rice. However, rice plants applied with 500ppm + RR (T ) obtained the highest net 1 income of Php 59, 496.33, which is slightly higher than plants applied with 1,000 ppm PBZ + R.R. (T ) and inorganic fertilizers alone (T ) which had net incomes of 2 6 PhP58,215.17 and Php 54, 436.33, respectively.
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Purnomo, Zulkarnain, Jorry Karim, Bahtiar Senung e Syahrir Abdussamad. "Sistem Informasi Jasa Pemesanan Percetakan Berbasis Android". Jambura Journal of Electrical and Electronics Engineering 2, n. 2 (2 luglio 2020): 44–51. http://dx.doi.org/10.37905/jjeee.v2i2.6006.
Testo completoAbstract (sommario):
Percetakan Mufidah Digital Printing setiap bulannya melayani order pencetakan, yang menjadi permasalahan selama ini adalah proses pelayanan kepada pelanggan yang akan melakukan order jasa percetakan tidak dapat terlayani dengan cepat hal ini karena banyaknya pelanggan serta ruang yang tersedia tidak terlalu luas dan pelanggan harus mendatangi Percetakan Mufidah Digital Printing untuk melakukan order pencetakan. Tujuan dari artikel ini untuk merancang sistem informasi jasa pemesanan percetakan berbasis android pada Percetakan Mufida Digital Printing Kota Gorontalo untuk memudahkan pelanggan melakukan pemesanan percetakan. Dalam merancang aplikasi ini menggunakan bahasa UML (Unified Modelling Language) dan diimplementasikan dengan menggunakan Android Studio, PHP dan MySQL. Metode yang digunakan adalah penelitian deskriptif yang berusaha menggambarkan dan menginterpretasi objek sesuai dengan apa adanya, di dalamnya terdapat upaya mendeskripsikan, mencatat, analisa, dan menginterprestasikan kondisi-kondisi yang saat ini terjadi atau ada. Berdasarkan hasil pengujian dengan menggunakan test case membuktikan bahwa sistem informasi jasa pemesanan percetakan berbasis android pada mufida digital printing ini lebih efektif dan efisien dibandingkan secara manual. Hasil pengujian: V (G) = 20 – 17 + 2 = 5, V (G) = 4 + 1 = 5, Cyclomatic Complexity (CC) = R1, R2, R3,R4,R5= 5. Diperoleh kesimpulan bahwa desain system informasi jasa pemesanan percetakan berbasis android dapat memudahkan konsumen untuk melakukan order percetakan dengan kelebihan fitur tambahan berupa notifikasi untuk pelanggan sehingga mempermudah proses produksi dari order cetakan yang dilakukan.Kata Kunci : Sistem Informasi, Mufida , android, php, mysql Printing of Mufidah Digital Printing every month serving printing orders, which has been a concern so far is the process of service to customers who will order printing services cannot be served quickly because this Mufidah Digital Printing customers make printing orders. The purpose of this article is to open an android-based printing order ordering information system in Gorontalo City Mufida Digital Printing Printing to provide printing ordering services. In completing this application using the UML (Unified Modeling Language) language and implemented using Android Studio, PHP and MySQL. The method used is descriptive research that discusses and interprets objects that are in accordance with what exists, where there are those that involve describing, loading, analyzing, and interpreting the conditions that currently occur or exist. Based on the test results using a test case prove that the Android-based ordering information system on digital printing mufida is more effective and efficient using manuals. Test results: V (G) = 20-17 + 2 = 5, V (G) = 4 + 1 = 5, Cyclone Complexity (CC) = R1, R2, R3, R4, R5 = 5. Obtained by the information system design Android-based printing order orders can make it easier for customers to order printing by loading additional notification features for customers to make the production process from ordering prints.Keywords: Information Systems, Mufida, android, php, mysql
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MAROKHÁZI, Judit, György KÓCZÁN, Ferenc HUDECZ, László GRÁF, András FODOR e István VENEKEI. "Enzymic characterization with progress curve analysis of a collagen peptidase from an enthomopathogenic bacterium, Photorhabdus luminescens". Biochemical Journal 379, n. 3 (1 maggio 2004): 633–40. http://dx.doi.org/10.1042/bj20031116.
Testo completoAbstract (sommario):
A proteolytic enzyme, Php-B (Photorhabdus protease B), was purified from the entomopathogenic bacterium, Photorhabdus luminescens. The enzyme is intracellular, and its molecular mass is 74 kDa. Tested on various peptide and oligopeptide substrates, Php-B hydrolysed only oligopeptides, with significant activity against bradykinin and a 2-furylacryloyl-blocked peptide, Fua-LGPA (2-furylacryloyl-Leu-Gly-Pro-Ala; kcat=3.6×102 s−1, Km=5.8×10−5 M−1, pH optimum approx. 7.0). The pKa1 and the pKa2 values of the enzyme activity (6.1 and 7.9 respectively), as well as experiments with enzyme inhibitors and bivalent metal ions, suggest that the activity of Php-B is dependent on histidine and cysteine residues, but not on serine residues, and that it is a metalloprotease, which most probably uses Zn2+ as a catalytic ion. The enzyme's ability to cleave oligopeptides that contain a sequence similar to collagen repeat (-Pro-Xaa-Gly-), bradykinin and Fua-LGPA (a synthetic substrate for bacterial collagenases and collagen peptidases), but not native collagens (types I and IV) or denatured collagen (gelatin), indicates that Php-B is probably a collagen peptidase, the first enzyme of this type to be identified in an insect pathogen, that might have a role in the nutrition of P. luminescens by degrading small collagen fragments. For the determination of enzyme kinetic constants, we fitted a numerically integrated Michaelis–Menten model to the experimental progress curves. Since this approach has not been used before in the characterization of proteases that are specific for the P1´–P4´ substrate sites (e.g. collagenolytic enzymes), we present a comparison of this method with more conventional ones. The results confirm the reliability of the numerical integration method in the kinetic analysis of collagen-peptide-hydrolysing enzymes.
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Adrian George, T., e Hassan H. Hammund. "Synthesis and characterization of low valent complexes of molybdenum containing the tridentate ligand PhP(CH2CH2PPh2)2 (TRI)". Journal of Organometallic Chemistry 503, n. 1 (novembre 1995): C1—C3. http://dx.doi.org/10.1016/0022-328x(95)05563-5.
Testo completo
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Ton-ogan, Martin, e Dionesio M. Bañoc. "Response of Black, Red, and White Rice (Oryza sativa L.) Cultivars to Nutrient Management Under Highly Alkaline Soil". Science and Humanities Journal 14, n. 1 (12 dicembre 2020): 68–82. http://dx.doi.org/10.47773/shj.1998.141.5.
Testo completoAbstract (sommario):
Increasing rice productivity under highly alkaline soil is possible by using appropriate cultivars and efficient nutrient management. This study determined the agronomic and yield response of three rice cultivars to nutrient management under highly alkaline soil. It evaluated rice production's profitability using three rice cultivars influenced by nutrient management under highly alkaline soil. The experiment was laid out in a split-plot arranged in an RCBD with rice cultivars as the main plot and nutrient management as the subplot. Statistical analysis revealed that fertilized plants headed and matured earlier than unfertilized plants. A significant interaction effect was noted among rice cultivars under different nutrient management. The combination of organic and inorganic fertilizers increased the percentage of filled spikelets while reducing unfilled spikelets. Application of 2.5 t/ha-1 poultry litter + 60-30-30 kg ha-1 N, P O , and K O (T ), significantly increased the 2 5 2 4 number of productive tillers, the weight of grains hill-1, and grain yield (t/ha-1) compared to plants applied with pure inorganic fertilizer. For cost and return analysis, black rice and T achieved the highest gross margins of PHP 297,708.28 4 and PHP 269,845.68 respectively. The results indicated that using black rice applied with 2.5 t/ha-1 poultry litter + 60-30-30 kg ha-1 N, P O , and K O (T ) is a highly effective 2 5 2 4 and profitable option for lowland rice production under highly alkaline soil.
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IKEDA, Yasuyuki, Katsumi GOJI e Atsuko TAKAGI. "A compound heterozygote for a novel missense mutation (G105R) in exon 3 and a missense mutation (D204E) in exon 5 of the lipoprotein lipase gene in a Japanese infant with hyperchylomicronaemia". Clinical Science 99, n. 6 (21 novembre 2000): 569–78. http://dx.doi.org/10.1042/cs0990569.
Testo completoAbstract (sommario):
We systematically investigated the molecular defects resulting in primary lipoprotein lipase (LPL) deficiency in a Japanese male infant (hereafter called ‘the patient’) with severe fasting hypertriglyceridaemia (type I hyperlipoproteinaemia). The primary LPL deficiency was diagnosed on the basis of the findings that no LPL activity was detected in post-heparin plasma (PHP) and that the immunoreactive LPL mass in PHP was less than 2% of the control level. The patient was a compound heterozygote for a novel missense mutation (G̲568GA → A̲GA/Gly105 → Arg; G105R) in exon 3 and a missense mutation (GAC̲867→GAG̲/Asp204→Glu; D204E) in exon 5 of the LPL gene. The biological significance of both missense mutations was examined by an in vitro study of the expression of the mutant G105R LPL cDNA and D204E LPL cDNA in COS-1 cells. Both mutant LPLs were catalytically inactive and were barely released by heparin from the expressing COS-1 cells. These findings explain the failure to detect LPL activity and immunoreactive LPL mass in the patient's PHP. The G105R allele could be detected by digestion with the BsmAI restriction enzyme, and the D204E allele by digestion with HincII. The patient inherited the G105R allele from his mother and the D204E allele from his father. His parents were heterozygotes for the corresponding mutant allele, but normolipidaemic. The novel G105R missense mutation could not be detected by conventional analysis of single-strand conformation polymorphism, but it was identified by extensive sequencing of the entire exons and their flanking regions in the LPL gene.
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Handler, Andreas, Paul Peringer e Ernst P. Müller. "Synthesis and NMR spectroscopy of the five-coordinate platinum(II) complexes [Pt(pp2-P,P′,P″)(dppmE-P,E)](O3SCF3)2 [pp2 = PhP(CH2CH2PPh2)2, dppme = Ph2PCH2P(E)Ph2, E = S, Se]". Polyhedron 10, n. 20-21 (gennaio 1991): 2471–74. http://dx.doi.org/10.1016/s0277-5387(00)86210-5.
Testo completo
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Wong, Wai-Kwok, Fong Lung Chow, Hua Chen, Boon Wai Au-Yeung, Ru-Ji Wang e Thomas C. W. Mak. "Preparation and reactivity of PhP(C5Me4H)2 and Ph2P(C5Me4H). X-ray crystal structures of Mo(CO)5[Ph2P(C5Me4H)] and (η5-C5Me4H)Mo(CO)(μ-PPh2)2Mo[(η5-C5Me4)P(O)Ph2](CO) · 1/4C6H14". Polyhedron 9, n. 24 (gennaio 1990): 2901–9. http://dx.doi.org/10.1016/s0277-5387(00)84199-6.
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Wolfsberger, Werner, Jürgen Bank e Helmut Werner. "Synthese dreizähniger Phosphanliganden RP[(CH2)n]2 (Y = OR′ oder CO2R′, n = 1 oder 2) sowie einiger zweizähniger chiraler Phosphane R2PCH(CH3)CO2Me / Synthesis of Tridentate Phosphine Ligands RP[(CH2)nY]2 (Y = OR′ or CO2R′, n = 1 or 2) and Some Bidentate Chiral Phosphines R2PCH(CH3)CO2Me". Zeitschrift für Naturforschung B 50, n. 9 (1 settembre 1995): 1319–28. http://dx.doi.org/10.1515/znb-1995-0904.
Testo completoAbstract (sommario):
AbstractThe bis(γ-alkoxypropyl)phosphines RP(CH2CH2OR′)2 1-4 were prepared by the reaction of RPLi2 (generated by lithiation of RPH2 with n-BuLi) with ClCH2CH2OR′. Deprotonation of the alkyl group R of RPH2 by n-BuLi and other side reactions leading preferably to diphosphines of the formula R [R′O(CH2)2]PP[(CH2)2OR′]R are responsible for the low yields of 1-4. The bis(propionate) analogues PhP(CH2CH2CO2R′)2 5 and 6 were readily accessible by hydrophosphination of methyl and ethyl acrylate with phenylphosphine, whereas the corresponding compounds RP(CH2CO2R′)2 7 -14 were best prepared by desilylation of RP(SiMe3)2 with C1CH2CO2R′. A similar reaction between R2PSiMe3 and the commercially available R - (+) - ClCH(CH3)CO2Me resulted in the formation of the chiral phosphinoesters R2PCH(CH3)CO 2Me 15-17. In the case of 15 and 16 partial racemation took place during the preparation, whereas 17 could be isolated in an enantiomerically pure form.
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Dugonjic, Sanja, Snezana Cerovic, Zoran Jankovic e Boris Ajdinovic. "Correlation of subtraction parathyroid scintigraphy with weight, pathohistologic finding and oxyphil cell content of parathyroid glands in parathyroid hyperplasia". Vojnosanitetski pregled 69, n. 4 (2012): 345–52. http://dx.doi.org/10.2298/vsp1204345d.
Testo completoAbstract (sommario):
Background/Aim. Parathyroid hyperplasia (PHP) is defined as an absolute increase in the mass of parenchymal cells of the parathyroid gland. PHP is classified as primary, secondary and tertiary. The enlargement of parathyroid glands (PG) is usually asymmetric, resulting in a ?dominant? gland. In order to confirm the diagnosis, at least two glands should be examined histologically. Subtotal parathyroidectomy, i.e. removal of the three PG and leaving a small remnant of the forth, is the treatment of choice. High percent of PHP recurrence imposes the need for preoperative high sensitivity localizing procedures. Parathyroid scintigraphy localizes about 60% of hyperplastic glands. The aim of this study was to correlate findings of subtraction parathyroid scintigraphy (SPS) with weight, pathohistologic finding and oxyphil cell (OC) content of PG in patients with primary, secondary and tertiary parathyroid hyperplasia. Methods. Twenty-seven patients with primary/secondary PHP underwent SPS before surgery. Scintigraphic results were graded from 1-5, in relation to the degree of uptake. SPS graded 3, 4 and 5 were considered positive. The number and weight of operated PG were evaluated macroscopically. Pathohistologic and cellular types were defined on standard stained hematoxylin-eosin slides. OC content was defined as a percent of OC and graded from 1 to 3: grade 1 < 10%, grade 2 ? 10% and grade 3 ? 20% of OC. Results. SPS localized dominant gland in all patients with sensitivity 100%, and 51 from 73 hyperplastic PG, with sensitivity per gland of 70%. PG weighed 0.1 g to 6.7 g (median 1 g). A significant positive correlation (p < 0.0001) was found between the SPS results and PG weight. A significant positive correlation was found between PG weight and OC content (p = 0.0002). An insignificant correlation was found between SPS and OC content. Thirty-eight PG had < 10% of OC, 32 PG had < 10% and 3 PG had ? 20% of OC. Four patients had diffuse PHP and 23 patients nodular PHP. There was no statistically significant difference in SPS results compared to hyperplasia type, and between OC content and hyperplasia type. A significant positive correlation (p = 0.05) was found between PG weight and hyperplasia type. Conclusion. A high positive correlation was found between SPS results and PG weight, PG weight and OC content and PG weight and hyperplasia type. Between SPS results and OC content, and between SPS results and hyperplasia type, an insignificant correlation was found. Our results showed that SPS is a reliable and very sensitive diagnostic tool in detecting abnormal PG in parathyroid hyperplasia, reaching 100% sensitivity in detecting a ?dominant gland? and sensitivity per localized gland of 70%. Causes that affect increased uptake of liposolubile Tc99m radiopharmaceuticals (RF) in the hyperfunctional PG tissue and conditions which prevent RF admission into the PG cells still remain to be accurately and precisely determined.
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Sembiring, Evaliata Br, e Wachid Zaini. "E-Book Pelajaran IPA Berbasis Mobile (Studi Kasus: Pelajaran IPA Kelas 5 SD)". Journal of Applied Informatics and Computing 6, n. 1 (12 maggio 2022): 64–70. http://dx.doi.org/10.30871/jaic.v6i1.3326.
Testo completoAbstract (sommario):
Buku Sekolah Elektronik merupakan sebuah buku digital atau elektronik agar dapat membantu proses pembelajaran peserta didik dimanapun dan kapanpun berada. Pembuatan ebook ini didasarkan karena pandemi covid-19 yang menyebabkan pembelajaran dilakukan dari rumah. Proses pembuatan e-book menggunkan pendekatan Luther Sutopo dengan memanfaatkan beberapa tool antara lain: Framework React Native, HTML, PHP, Javascript Framework, AngularJS, dan Node.js. E-book yang dihasilkan, dianalisis menggunakan metode evaluasi goal-attainment untuk mengetahui tingkat pemahaman minat belajar siswa. Hasil penelitian adalah: (1) E-book berhasil dibuat dalam bentuk aplikasi mobile dengan memenuhi kategori e-book yaitu dilengkapi dengan fitur login untuk keamanan pengguna, materi pelajaran dalam bentuk video, pdf, gambar dan evaluasi dalam bentuk soal pilihan ganda; (2) Produk telah digunakan oleh responden (siswa) dan berdasarkan analisisi goal attainment, diperoleh nilai MOS sebesar 4.6 berarti pengguna aplikasi sangat puas menggunakan aplikasi sehingga layak dijadikan alternatif media pembelajaran siswa di rumah.
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Putri, Weni Lestari. "Penggunaan Monte Carlo Untuk Optimalisasi Prediksi Pengadaan Barang Di QShop Batam". JR : Jurnal Responsive Teknik Informatika 2, n. 01 (28 ottobre 2021): 100–108. http://dx.doi.org/10.36352/jr.v2i01.229.
Testo completoAbstract (sommario):
Tujuan dari Penelitian -Memahami penggunaan Monte Carlo untuk prediksi data pemesan sehingga sistem barang dari pengadaan dapat optimal dan berguna bagi supplier Qshop. -Menganalisa penggunaan algoritma Monte Carlo untuk perhitungan barang dari pemesanan konsumen dalam memprediksi 2 tahun kedepan. Dalam hal penyelesaian dengan metode Monte Carlo yang akan dilakukan adalah mensimulasikan permintaan barang - barang aksesoris mobil 2 tahun dan untuk mendapatkan hasil prediksi pengadaan 2 tahun mendatang di Qshop Batam yang terletak di Nagoya. Adapun langkah-langkah penyelesaian metode Monte Carlo adalah 1.Menetukan tabel distribusi. 2.Menentukan distribusi kemungkinan dan kumulatif. 3.Menentukan interval angka random untuk setiap variabel. 4.Membuat angka random. 5.Membuat simulasi dari rangkaian percobaan. Penggunaan metode simulasi Monte Carlo untuk prediksi kebutuhan persediaan barang berguna bagi supplier Qshop. Metode menggunakan model determistik parametik. Peneliti berkesimpulan bahwa - Penggunaan metode simulasi Monte Carlo untuk prediksi kebutuhan persediaan barang berguna bagi supplier Qshop. -Penggunaan algoritma Monte Carlo dapat diimplementasikan dengan Microsoft Excel dan Aplikasi PHP didapat hasil yang sama. Pada penelitian ini, penulis mencoba memprediksi jumlah pengadaan barang aksesoris mobil dan keuntungan yang diperoleh yaitu dengan penerapan simulasi metode Monte Carlo. Untuk melakukan prediksi tersebut penulis mencoba merancang sebuah aplikasi berbasis Web dengan Bahasa Pemrograman PHP. Oleh sebab itu perlunya dilakukan pengembangan terhadap sistem yang telah di rancang sehingga menghasilkan hasil prediksi yang efektif dan efisien.
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Zhao, Wenqi, Ying Zhou, Yuqing Yuan, Zhihong Fan, Yixue Wu, Anshu Liu e Xuejiao Lu. "Potato Preload Mitigated Postprandial Glycemic Excursion in Healthy Subjects: An Acute Randomized Trial". Nutrients 12, n. 9 (10 settembre 2020): 2759. http://dx.doi.org/10.3390/nu12092759.
Testo completoAbstract (sommario):
This study investigated the preload effect of the medium and high glycemic index (GI) potato, as well as the combination of partially hydrolyzed guar gum (HG) and potato, when ingested prior to a rice meal, on the iso-carbohydrate basis. In a randomized crossover trial, 17 healthy female subjects consumed (1) rice; (2) co-ingestion of highly cooked potato (HP), and rice (HP + R); (3) co-ingestion of minimally cooked potato (MP) and rice (MP + R); (4) preload HP prior to rice meal (PHP + R); (5) preload MP prior to rice meal (PMP + R); (6) co-ingestion of partially hydrolyzed guar gum (HG), HP and rice (HG + HP + R); (7) preload HG prior to co-ingestion of HP and rice (PHG + HP + R); (8) co-preload of HG and HP prior to rice (PHG + PHP + R); and (9) preload of HP prior to co-ingestion of HG and rice (PHP + HG + R). Postprandial glycemic response (GR) tests and subjective satiety tests were conducted for each test food. Cooked potato as a preload to a rice meal could significantly cut the acute postprandial glycemic excursion by around 1.0 mmol/L, irrespective of the GI of the preload. Co-preload of partial hydrolyzed guar gum and highly cooked potato (PHG + PHP + R) resulted in improved acute GR in terms of peak glucose value and glycemic excursion compared with either HG preload or HP preload. All the meals with preload showed comparable or improved self-reported satiety. Within an equicarbohydrate exchange framework, both high-GI and medium-GI potato preload decreased the postprandial glycemic excursion in young healthy female subjects. The combination of HG and HP as double preload resulted in better GR than both single HG or HP preload did.
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Fitriyani, Fitriyani, e Zakaria H.M Yusuf. "ANALISIS DAN PENGEMBANGAN SISTEM INFORMASI PENERIMAAN MAHAMAHAMAHASISWA BARU BERBASIS CODEIGNITER PHP FRAMEWORK". Jurnal Sains Riset 12, n. 3 (30 novembre 2022): 729–32. http://dx.doi.org/10.47647/jsr.v12i3.996.
Testo completoAbstract (sommario):
This study aims to develop a New Student Admissions Information System Based on Codeigniter PHP Framework. This software serves to simplify the process of registering new students who so far still use paper documents and Microsoft Excel. This study also aims to test the software based on McCall's quality factors which include correctness, reliability, efficiency, integrity, and usability. This research method is Research and Development. The development model used is Waterfall which consists of analysis, design, implementation, and testing. The data in this study were obtained from: (1) the correctness test using the KLOC calculation; (2) reliability testing using Blitz, Loader, LoadImpact, and Blazemeter; (3) efficiency testing using Pagespeed Insights, YSlow, Pingdom Tools, and Websitetest; (4) integrity testing using Acunetix and Netsparker; and (5) usability testing using the PSSUQ (Post-Study System Usability Questionnaire) questionnaire on fifty one respondents including lecturers, academic administration and students at Jabal Ghafur University.Keywords: Information Systems, Admission of New Students, CodeIgniter, McCall
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Caguay, Marjun E. "Development of a Mini Ginger Chopping Machine". International Journal for Research in Applied Science and Engineering Technology 11, n. 7 (31 luglio 2023): 885–89. http://dx.doi.org/10.22214/ijraset.2023.54760.
Testo completoAbstract (sommario):
Abstract: In the Philippines, ginger processing operations, especially in small and medium-scale processing centers, require significant time, financial investment, and effort. This is primarily due to the lack of affordable and cost-effective chopping machines specifically designed for ginger processing. Consequently, the objective of the study was to develop a mini ginger chopping machine that addresses these constraints and meets the requirements of local ginger processors and workers. The machine was composed of five major parts: the hopper, chopping chamber, power transmission system, prime mover, and frame. Locally produced ginger was used as test materials for the experiments, which included three treatment speeds: 250, 350, and 450 rpm. The experiment was conducted using a completely randomized design (CRD), and the performance parameters of the machine were analyzed using an analysis of variance (ANOVA) test. Furthermore, a least significant difference (LSD) test was employed to compare the means, with a 5% significance level. The results demonstrated that the highest chopping capacity of 38.6 kg/hr was achieved at a shaft speed of 450 rpm, with a chopping efficiency of 96.13%. However, a significant portion of the device's inefficiency stemmed from the presence of unchipped materials, amounting to 2.74% of the total inputted test materials. The majority of the product sizes ranged from 2 to 4 mm, indicating consistency in the chopping process. A cost analysis revealed that the machine needed to process a total of 649.5 kg of ginger to reach the breakeven point, considering a custom rate of Php 2/kg. With an initial investment cost of Php 8,000, the machine could recoup this investment in just 3.36 months (equivalent to 74 working days), and additionally provide a net income of Php 21,641.55 per year to ginger processors.
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Carsote, Mara, Claudiu Nistor, Mihaela Stanciu, Florina Ligia Popa, Remus Calin Cipaian e Ovidiu Popa-Velea. "Neuroendocrine Parathyroid Tumors: Quality of Life in Patients with Primary Hyperparathyroidism". Biomedicines 11, n. 7 (21 luglio 2023): 2059. http://dx.doi.org/10.3390/biomedicines11072059.
Testo completoAbstract (sommario):
Tumors of the parathyroid glands, when associated with PTH (parathyroid hormone) excess, display a large area of complications; in addition to the classical clinical picture of primary hyperparathyroidism (PHP), a complex panel of other symptoms/signs can be identified, including memory and cognitive impairment, chronic asthenia/fatigue, reduced muscle functionality, depressive mood, non-specific bone pain, and loss of sleep quality. The perception of quality of life (QoL) can be supplementarily enhanced by their progressive onset, which makes many patients not be fully aware of them. Their improvement was reported very early after parathyroidectomy (PTx), yet the level of statistical evidence does not qualify these non-classical elements as standalone indications for PTx. Our objective is introducing an up-to-date on QoL scores with regards to the patients diagnosed with PHP, particularly taking into consideration PHP management from baseline to post-operatory outcome, including in cases with multiple endocrine neoplasia. This is a narrative review of literature. We revised full-length papers published in English through PubMed research conducted between January 2018 and May 2023 by using the key words “quality of life” and “primary hyperparathyroidism”. We particularly looked at data on self-reported QoL (through questionnaires). We excluded from the search the studies focused on non-PTH related hypercalcemia, secondary, and/or renal/tertiary hyperparathyroidism, and vitamin D supplementation. Overall, we identified 76 papers and selected for the final analysis 16 original studies on QoL and PHP (a total of 1327 subjects diagnosed with syndromic and non-syndromic PHP). The studies with the largest number of individuals were of 92, 104, 110, 134, 159, as well as 191. A few cohorts (n = 5) were of small size (between 20 and 40 patients in each of them). Concerning the study design, except for 2 papers, all the mentioned studies provided longitudinal information, particularly the timeframe from baseline (before PTx) and after surgery. The post-operatory follow-up was of 3–6 months, but mostly between 1 and 3 years (maximum a decade of surveillance). The age of the patients varies between medians of 56, 62, 64, and 68 years. Most frequent questionnaires were SF-36, PHPQoL, and PAS. Despite not being unanimously similar, an overall reduced score of QoL in patients with PHP versus controls was registered, as well as general improvement following PTx. Variations of QoL results might have a multifactorial background from different comorbidities, studied populations, technical aspects of collecting the data, etc. QoL scores in PHP represents a complex heterogeneous picture, from their correlation with clinical features and lab assays (e.g., the level of serum calcium), the associated comorbidities (such as multiple endocrine neoplasia syndromes), up to the assessment of the QoL improvement after parathyroidectomy (PTx). While current studies do not unanimously agree on each QoL domain, the assessment of QoL might represent a supplementary argument to consider when deciding for PTx, especially in asymptomatic cases and in patients who do not fit into well-known categories of surgery candidates, according to current guidelines, thus assessing QoL in PHP is part of a current research gap. QoL evaluation in PHP remains an open issue, towards which awareness should be cultivated by both endocrinologists and surgeons. The introduction of a routine evaluation of the QoL scores in patients, as well as the selection of the most appropriate questionnaire(s), represents an open chapter thus awareness in mandatory.
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Gavrilović, Ivana, Yunita Gelu e Vincenzo Abbate. "In Vitro Metabolic Study of Four Synthetic Cathinones: 4-MPD, 2-NMC, 4F-PHP and bk-EPDP". Metabolites 12, n. 2 (25 gennaio 2022): 115. http://dx.doi.org/10.3390/metabo12020115.
Testo completoAbstract (sommario):
The use of illicit drugs is exceedingly prevalent in society, and several of them can be illegally purchased from the internet. This occurrence is particularly augmented by the rapid emergence of novel psychoactive substances (NPS), which are sold and distributed as “legal highs”. Amongst NPS, the class of synthetic cathinones represents stimulant substances exhibiting similar effects to amphetamine and its derivatives. Despite potentially being less psychoactive than amphetamine, synthetic cathinones are harmful substances for humans, and little or no information is available regarding their pharmacology and toxicology. The present study investigated the in vitro metabolism and metabolites of four recent synthetic cathinones, namely, 1-(4-methylphenyl)-2-(methylamino)-pentanone (4-MPD), 1-(4-methylphenyl)-2-dimethylamino-propanone (2-NMC), 1-(4-fluorophenyl)-2-(pyrrolidin-1-yl-hexanone (4F-PHP) and 1-(1,3-benzodioxol-5-yl)-2-(ethylamino)-1-pentanone (bk-EPDP). Our in vitro metabolism study resulted in 24 identified metabolites, including both phase I and phase II metabolites. All metabolites were detected and identified using liquid chromatography–high-resolution mass spectrometry and may serve as additional markers of abuse of these NPS in toxicological analyses.
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Santoso, Firman, Sufil Wilda e Zaehol Fatah. "SISTEM INFORMASI PENERIMAAN SISWA BARU BERBASIS WEB DI SMK KHAMAS ASEMBAGUS MENGGUNAKAN PHP". Jurnal Advanced Research Informatika 1, n. 02 (5 luglio 2023): 8–15. http://dx.doi.org/10.24929/jars.v1i02.2615.
Testo completoAbstract (sommario):
Penerimaan peserta didik baru (PPDB) Online adalah sebuah sistem yang dirancang untuk melakukan seleksi otomatis mulai dari pendaftaran, peroses seleksi hingga proses pengumuman seleksi. Sistem PPDB online ini diharapkan mampu memenuhi harapan masyarakat tentang implementasi penerimaan peserta didik baru yang objektif, transparan dan akuntabel. Penelitian ini dilakukan untuk mendeskripsikan manajemen penerimaan peserta didik baru online jenjang SMK Khamas Asembagus Situbondo, meliputi perencanaan, pengorganisasian, pelaksanaan, pengendalian, faktor-faktor penunjang keberhasilan dan faktor penghambatnya. Penelitian ini dilatarbelakangi oleh permasalahan dalam pelaksanaan penerimaan peserta didik baru SMK Khamas Asembagus yang masih dilaksanakan dengan cara mendftarkan menggunakan formulir ketras yang diberikan kepada calon peserta didik baru sehingga memakan waktu yang lama. Metode yang digunakan dalam penelitian ini adalah (1) metode kualitatif pendekatan deskriptif, (2) lokasi penelitian dilaksanakan di SMK Khamas asembagus Situbondo, (3) sumber data informan tim PPDB online, (4) teknik pengumpulan data yang dilakukan adalah wawancara. Berdasarkan hasil penelitian, (1) Perencanaan PPDB Online meliputi pembentukan panitia, pelaksanaan, pembuatan website, (2) Pelaksanaan PPDB online berdasarkan petunjuk pelaksanaan yang tercantum dalam peraturan Sekolah yang meliputi pendaftaran, seleksi sampai pendaftaran ulang. (3) Pengendalian dilakukan melalui pengawasann oleh tim pengawasan dan pengaduan serta evaluasi yang dilakukan oleh tim PPDB tingkat kota dan sekolah. (4) Faktor-faktor penununjang keberhasilan PPDB online terdiri dari kejasama antar panitia. (5) Faktor penghambat terdiri dari SDM, keterbatasan infrastruktur, serta pemahaman terhadap teknologi.
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Jumadi, J., e Sigit Widiadi. "Pengembangan Aplikasi Sistem Informasi Geografis (SIG) berbasis Web untuk Manajemen Pemanfaatan Air Tanah menggunakan PHP, Java dan MySQL Spatial (Studi Kasus di Kabupaten Banyumas)". Forum Geografi 23, n. 2 (20 dicembre 2009): 1236. http://dx.doi.org/10.23917/forgeo.v23i2.5006.
Testo completoAbstract (sommario):
In the existing world of geographic information systems (GIS), desktop mapping has taken a critical role for managing and using spatial information for business. But desktop-based GIS application having any limitation for users. The research was conducted to develop the web-based GIS in order to manage groundwater exploration and production, preventing from uncontrolled exploration, using Java Applet, MySQL Spatial and PHP. The system development was designed by using waterfall model of system life cycle with following steps: 1) system requirements, 2) software requirements, 3) analysis, 4) program design, 5) coding, 6) testing, and 7) operation, supported by reference study, observation, and peer discussion. The result shows that by using Java Applet, MySQL Spatial and PHP, web-based GIS for groundwater management is customizable to create spatial modeling and well log modeling, user friendly, interactive, interoperable, informative, and easy to access with LAN/WAN connected PC. The application is very helpful in order to balance between groundwater supply and production, groundwater level monitoring, water quality monitoring, and groundwater user monitoring. Hopefully, the implementation of the system will help the groundwater supply conservation for sustainable development.
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D. Alejandrino, Darwin, e Lolita L. Beato. "PRODUCTION AND MARKETING PRACTICES OF BUNCHING ONION (ALLIUM FISTULOSUM L.) FARMERS IN PANGIL, LAGUNA". International Journal of Advanced Research 9, n. 10 (31 ottobre 2021): 01–15. http://dx.doi.org/10.21474/ijar01/13511.
Testo completoAbstract (sommario):
Bunching onion cultivation is becoming a popular enterprise in the 4th District of Laguna. A survey was conducted to evaluate the production and marketing practices of bunching onion farmers in Pangil, Laguna. A total of 200 managers and caretakers of bunching onion farms in the study area were identified through purposive sampling. Questionnaire with a combination of close and open-ended questions was used in the interview. Chi- Square was used for testing the correlation and association.Results show that majority of the respondents, who have an average age of 51 years, indicate that bunching onion production is their primary source of income and they have been in farming for no less than 15 years. Less than 50% of the respondents have an average farm size of .5 hectare and majority of them are tenants. Most of the producers were not able to go beyond secondary education and majority, and has no affiliation to any farmers organization. Also, majority of the respondents have not attended any seminar on bunching onion production.Apart from the demographic profile, the respondents production and operation management of their bunching onion farms were documented. Marketing management, which includes pricing and selling, was recorded. Results reveal that both growers and viajeros are the ones who decide on the price of bunching onions.Based on the data, an average income of Php 436,450.00 can be earned from .5 hectare in one cropping. Return on Sales (ROS) of 90.93% shows that every peso earned from the sale of the product there is a corresponding Php 0.91 centavos net return. Return on Investment (ROI) of 10.02% shows that for every Php 1.00 invested there is a corresponding Php 0.10 centavos net return.The study revealed that the level of yield and profit per hectare per cycle isinfluenced by the educational attainment, household size, and farm size, but are not influenced by age of the respondents. The major problems of the bunching onion farmers are the high price of seeds, insufficient capital, insect pests and diseases. Data revealed that growing bunching onions is profitable and a considerable income can be obtained in 2 to 3 months. Conduct of similar studies on bunching onion production in other towns is recommended to compare the profitability and the practices. Encouraging the farmers to practice companion cropping or any cropping system with higher biodiversity on order to enhance productivity per unit area is likewise recommended. Further, the bunching onion farmers must be organized and be extended with applicable trainings and assistance by concerned agencies and entities in order to improve their status and productivity.
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Paris, J. B., A. J. Wilkie e A. R. Woods. "Provability of the pigeonhole principle and the existence of infinitely many primes". Journal of Symbolic Logic 53, n. 4 (dicembre 1988): 1235–44. http://dx.doi.org/10.1017/s0022481200028061.
Testo completoAbstract (sommario):
In this note we shall be interested in the following problems.Problem 1. Can IΔ0 ⊢ ∀x∃y > x(y is prime)?Here I Δ0 is Peano arithmetic with the induction axiom restricted to bounded (i.e. Δ0) formulae.Problem 2. Can IΔ0 ⊢ Δ0 PHP?Here Δ0 PHP (Δ0 pigeonhole principle) is the schemafor θ ∈ Δ0, or equivalently in IΔ0, for a Δ0 formula F(x,y)written .By obtaining partial solutions to Problem 2 we shall show that Problem 1 has a positive solution if IΔ0 is replaced by IΔ0 + ∀xxlog(x) exists.Our notation will be entirely standard (see for example [3] and [4]). In particular all logarithms will be to the base 2 and in expressions like log(x), (1 + ε)x, etc. we shall always mean the integer part of these quantities.Concerning Problem 2 we remark that it is shown in [5] that for k ∈ N and F ∈ Δ0,As far as we know this is the best result of this form, in that we do not know how to replace log(z)k by anything larger. However, as we shall show in Theorem 1, we can do much better if we increase the difference between the sizes of the domain and range of F.In what follows let M be a countable nonstandard model of IΔ0, and let be those subsets of M defined by Δ0 formulae with parameters from M.Theorem 1. For k ∈ N andF ∈ Δ0,Here log0(x) = x, logk + 1(x) = log(logk(x)).Proof. To simplify matters, consider first the case k = 1. So assume M ⊨ alog(a) exists and with and a > 1. The idea of the proof is the following.
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Warni, Eka Risma, Erwin Rosadi e Eka Anto Supeni. "SISTEM INFORMASI PERIKANAN TANGKAP BERBASIS WEB DI KABUPATEN TANAH LAUT PROVINSI KALIMANTAN SELATAN". Fish Scientiae 11, n. 1 (30 giugno 2021): 104–20. http://dx.doi.org/10.20527/fishscientiae.v11i1.175.
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Tujuan penelitian ini yaitu, untuk mengidentifikasi dan menganalisis elemen sistem perikanan tangkap Kabupaten Tanah Laut, serta merancang dan membangun sistem informasi perikanan tangkap Kabupaten Tanah Laut berbasis web. Penelitian ini dilaksanakan pada bulan Maret-Oktober 2020 di Kabupaten Tanah Laut. Bahasa pemograman yang digunakan yaitu PHP. Pembuatan database dan desain sistem informasi menggunakan aplikasi XAMPP dan Sublime Text. Metode dalam membangun sistem ini dilakukan dengan menggunakan The Waterfall Model, adapun tahapannya yaitu 1) Analisis kebutuhan, 2) Tahap perancangan sistem informasi, 3) Tahap implementasi sistem informasi, 4) Tahap validasi sistem informasi, dan 5) Tahap pemeliharaan (maintenance). Hasil Penelitian menunjukkan bahwa elemen sistem perikanan tangkap di Kabupaten Tanah Laut yaitu terdiri dari nelayan, Dinas Ketahanan Pangan dan Perikanan, Pelabuhan Muara Kintap, dan Pengusaha Perikanan dan sistem informasi ini yaitu Sistem Informasi Perikanan Tangkap Tanah Laut (SI-PTTL) dengan 5 komponen yaitu SI-PTTL, admin, database, informasi, dan user . Menu yang ditampilkan pada SI-PTTL ialah menu profil admin, data master, data transaksi, dan grafik
The purpose of this research is to identify and analyze elements of the Tanah Laut district capture fisheries system, as well as to design and build a web-based capture fisheries information system in Tanah Laut District. This research was conducted in March-October 2020 in Tanah Laut District. The programming language used is PHP. Database creation and information system design using XAMPP and Sublime Text applications. the method of building this system is done by using The Waterfall Model. The stages include 1) Requirements analysis, 2) Information system design stage, 3) Information system implementation stage, 4) Information system validation stage, and 5) Maintenance stage. The results showed that elements of the capture fisheries system in Tanah Laut District consisted of fishermen, the Department of Food Security and Fisheries, Muara Kintap Port, and Fisheries Entrepreneurs. The menu displayed on the SI-PTTL is the admin profile menu, master data, transaction data, and graphics
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Ang, How-Ghee, Lip-Lin Koh e Qi Zhang. "Synthesis and structural studies of new ruthenium cluster carbonyl derivatives from (PhP)5 and [Ru3(CO)12] and [Ru3(CO)10(NCMe)2]". Journal of the Chemical Society, Dalton Transactions, n. 17 (1995): 2757. http://dx.doi.org/10.1039/dt9950002757.
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Gómez-Benı́tez, Valente, Simón Hernández-Ortega e David Morales-Morales. "Synthesis of a neutral SPS pincer Pd(II) complex with the proligand PhP(C6H4SH-2)2 [phPS2H2]. The X-ray crystal structure of [Pd(phPS2)(PPh3)]". Inorganica Chimica Acta 346 (marzo 2003): 256–60. http://dx.doi.org/10.1016/s0020-1693(02)01372-5.
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