Letteratura scientifica selezionata sul tema "Phosphorelays"
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Articoli di riviste sul tema "Phosphorelays":
Alves, Rui, Baldiri Salvadó, Ron Milo, Ester Vilaprinyo e Albert Sorribas. "Maximization of information transmission influences selection of native phosphorelay architectures". PeerJ 9 (10 giugno 2021): e11558. http://dx.doi.org/10.7717/peerj.11558.
Csikász-Nagy, Attila, Luca Cardelli e Orkun S. Soyer. "Response dynamics of phosphorelays suggest their potential utility in cell signalling". Journal of The Royal Society Interface 8, n. 57 (11 agosto 2010): 480–88. http://dx.doi.org/10.1098/rsif.2010.0336.
Thomason, P., e R. Kay. "Eukaryotic signal transduction via histidine-aspartate phosphorelay". Journal of Cell Science 113, n. 18 (15 settembre 2000): 3141–50. http://dx.doi.org/10.1242/jcs.113.18.3141.
Koppenhöfer, Sonja, e Andrew S. Lang. "Interactions among Redox Regulators and the CtrA Phosphorelay in Dinoroseobacter shibae and Rhodobacter capsulatus". Microorganisms 8, n. 4 (14 aprile 2020): 562. http://dx.doi.org/10.3390/microorganisms8040562.
Chen, Y. Erin, Christos G. Tsokos, Emanuele G. Biondi, Barrett S. Perchuk e Michael T. Laub. "Dynamics of Two Phosphorelays Controlling Cell Cycle Progression in Caulobacter crescentus". Journal of Bacteriology 191, n. 24 (25 settembre 2009): 7417–29. http://dx.doi.org/10.1128/jb.00992-09.
Schaller, G. Eric, Joseph J. Kieber e Shin-Han Shiu. "Two-Component Signaling Elements and Histidyl-Aspartyl Phosphorelays†". Arabidopsis Book 6 (gennaio 2008): e0112. http://dx.doi.org/10.1199/tab.0112.
Chauhan, Neeraj. "Two-component phosphorelays in fungal mitochondria and beyond". Mitochondrion 22 (maggio 2015): 60–65. http://dx.doi.org/10.1016/j.mito.2015.03.003.
Tierrez, Alberto, e Francisco García-del Portillo. "The Salmonella Membrane Protein IgaA Modulates the Activity of the RcsC-YojN-RcsB and PhoP-PhoQ Regulons". Journal of Bacteriology 186, n. 22 (15 novembre 2004): 7481–89. http://dx.doi.org/10.1128/jb.186.22.7481-7489.2004.
Kothamachu, Varun B., Elisenda Feliu, Carsten Wiuf, Luca Cardelli e Orkun S. Soyer. "Phosphorelays Provide Tunable Signal Processing Capabilities for the Cell". PLoS Computational Biology 9, n. 11 (7 novembre 2013): e1003322. http://dx.doi.org/10.1371/journal.pcbi.1003322.
Knudsen, Michael, Elisenda Feliu e Carsten Wiuf. "Exact analysis of intrinsic qualitative features of phosphorelays using mathematical models". Journal of Theoretical Biology 300 (maggio 2012): 7–18. http://dx.doi.org/10.1016/j.jtbi.2012.01.007.
Tesi sul tema "Phosphorelays":
Salvadó, López Baldiri. "Design principles in two component systems and his-asp phosphorelays". Doctoral thesis, Universitat de Lleida, 2016. http://hdl.handle.net/10803/393740.
El objectivo principal de esta tesis es la búsqueda de principios de diseño que relacionen la estructura y la función de redes bioquímicas de transducción de señales, concretamente en two-component systems (TCS) y phosphorelays (PR). La tesis se inicia con una revisión de los métodos usados para el estudio de principios de diseño en sistemas moleculares y algunos de los resultados obtenidos hasta ahora, seguida de una discusión sobre la importancia del estudio de dichos principios de diseño. A continuación, exploramos los proteomas secuenciados de más de 7000 organismos y hacemos un inventario de los distintos tipos de organización en operones o proteínas de los dominios proteicos implicados en TCS y PR, con el objetivo de deducir el repertorio de estructuras existentes en la naturaleza para estos circuitos moleculares. Para terminar, comparamos mediante modelización matemática las propiedades dinámicas de tres circuitos distintos de TCS, y observamos que una proteína adicional que interacciona con la histidina quinasa o con el response regulator modifica el espacio de valores de los parámetros del sistema en el cual existe biestabilidad.
The ultimate goal of this thesis is to set the stage for finding general design principles underlying the relationship between network design and network function in two-component (TCS) and His-Asp phosphorelay (PR) signal transduction systems. This thesis starts with a review of the methods for and results from the study of design principles in molecular systems, and a discussion about the importance of studying those design principles. Next, a survey of the fully sequenced and annotated genomes and proteomes of more than 7000 different organisms is performed in order to identify different types of organizations of the TCS/PR protein domains in operons and multidomain proteins. From this data, the existing diversity of TCS/PR circuit designs will be inferred. Finally, we compare through mathematical modeling the dynamic properties associated with three types of TCS circuit designs, and find that a third component that binds to and modulates the activity of either the sensor kinase or the response regulator can modify the parameter space in which bistability in the system’s response is possible.
Cochard, Clémence. "Régulation fine du système EnvZ/OmpR chez Dickeya dadantii : clef d'une infection réussie". Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS109.
Throughout their life, the bacteria must confront numerous environmental variations. They must adapt rapidly and effectively to ensure their survival. To accomplish this, they possess phosphorelays, or two-component systems, which are the major molecular tools enabling perception and adaptation to the environment in bacteria. These phosphorelays consist of a sensor and an associated regulator. Following the perception of a stimulus, the sensor autophosphorylates and transmits the phosphate group to the regulator, which then modulates the expression of the entire target gene set, known as a regulon. During the infection process, pathogenic bacteria must deal with multiple stresses. A significant number of these systems are found in various pathogenic bacteria, such as our study model Dickeya dadantii. Responsible for soft rot disease, D. dadantii is a wide-host-range phytopathogenic enterobacterium. It possesses a battery of 32 phosphorelays to deal with host defenses and the general stresses of nutritional deficiencies or physicochemical variations in the environment.First this study focuses on one of them, the EnvZ/OmpR system. My work initially shows that the pH in the plant remains acidic during infection. However, despite activation of the system by acidic pH, it is not activated during this process. To understand the reason for this inconsistency, the system's regulon was studied. It was then discovered that during the emergence of the Dickeya genus, the ompF gene, encoding the porin of the same name, was duplicated. Interestingly, the expression of ompF is constitutive, whereas that of ompF2, the duplicated gene, which is dependent on OmpR phosphorylation levels. The expression of this second porin is also detrimental to infection. Thus, during infection, the activation of EnvZ/OmpR is counteracted by the perception of host defense molecules to prevent the expression of ompF2 and enable proper virulence progression.In a second phase, a comprehensive study of the importance of each phosphorelay in D. dadantii's virulence was conducted in my work. The initial results show that only 6 systems are involved in virulence. The number and complexity of stresses encountered by pathogenic bacteria do not seem to align with this low number. Reducing the quantity of inoculated bacteria allowed for a more precise detection of the systems contributing to virulence, which now totals 12. Overall, these results indicate the significance of finely regulating the activity of a phosphorelay, as EnvZ/OmpR must be activated for infection, but this activation must be strongly controlled to avoid detrimental effects on virulence
Treffandier, Hélène. "Etude du phosphorelais RcsCDB/FA d'Escherichia coli". Toulouse 3, 2009. http://thesesups.ups-tlse.fr/797/.
Two-component systems, also called phosphorelays are the major signalling pathways in bacteria. They are widespread and mediate a large variety of adaptative cellular responses. The Rcs system of Escherichia coli is a complex phosphorelay composed of five proteins: RcsCDBFA. Exclusive to the Enterobacteriacae, the Rcs phosphorelay modulates biofilm formation and virulence in several pathogens. It is activated by membrane alterations and influences expression of 2 to 3% of the bacterial genome. However, the role of the Rcs system in adaptation to the environment remains elusive. The three objectives of my PhD were (i) to explore further the role of the Rcs system in adaptation to relevant environmental conditions (ii) to rationalize the complexity of the Rcs phosphorelay and, in particular, to explain the role of the accessory co-factor RcsA in the Rcs response (iii) to develop an integrated vision of the system through the identification of its protein partners. Within the framework of these objectives, my work proved that the Rcs system is essential for resistance to low pH, a situation encountered by E. Coli in mammals' stomach. My research also suggests that the accessory cofactor RcsA modulates the kinetics of expression of the whole RcsB regulon, in particular by prolonging the Rcs response after the phosphorelay's activating signal has stopped. To finish with, my work revealed a greater complexity in rcsA regulation than was previously thought to exist, by showing that it is twofold: transcriptional and post-transcriptional
Caby, Marine. "Rôle du phosphorelais EnvZ/OmpR chez la bactérie phytopathogène Dickeya dadantii". Thesis, Lille 1, 2020. http://www.theses.fr/2020LIL1S108.
During their lifetime, pathogenic bacteria are confronted with numerous environmental variations often referred to stress, particularly during infection. In order to survive and successfully colonize its host, the bacterium must perceive this new and dangerous environment to adapt quickly. This is the main role assigned to phosphorelays. These systems are composed of a sensor and a cognate regulator. Under the action of a stimulus, the sensor autophosphorylates and transmits the phosphate group to its regulator, which in turn modulates the activity of a set of target genes allowing adaptation to the new environment. Our experimental model Dickeya dadantii is a necrotrophic plant pathogen bacterium responsible for soft rot disease in a wide range of plant species. The variation of pH and osmolarity are two stresses often faced and fought by pathogenic bacteria. EnvZ/OmpR and RcsCDB phosphorelays are two major systems known to respond to these stresses. The laboratory had previously demonstrated that the level of activation of the RcsCDB system was dependent on the concentration of periplasmic osmoregulated glucans (OPG). Their concentration in the periplasm increases as the medium osmolarity decreases, making OPGs a major intermediate in the perception of osmolarity. This prompted us to decipher the relationship between EnvZ/OmpR and OPGs. I showed that, unlike for the activation of the RcsCDB system, the activation of EnvZ/OmpR doesn’t depend on the concentration of OPGs, but still requires its presence for proper activation of the phosphorelay. To go deeper into the EnvZ/OmpR system, activities of this system have been studied in vivo and in planta. While the EnvZ/OmpR system is activated in a medium with an acidic pH and a high osmolarity in E. coli, my work shows that only pH variation activates this phosphorelay in D. dadantii. In addition, only one major porin (versus two in E. coli) was previously detected in D. dadantii. My studies revealed the existence of a second porin expressed at acidic pH in vivo and in planta. These two OmpF-like porins are regulated by the pH via OmpR. After adaptation for a few hours in planta, the pattern of these two porines remains the same over the rest of the infection. However, the level of OmpR activation during the same period fluctuates indicating that at least one other environmental parameter modulates the activation of EnvZ/OmpR in planta. The steady state level of the porines in the envelope during this same period suggests that another regulatory system, perhaps RcsCDB may maintain their expression level
Huang, Ya-hui. "Genetic and functional analysis of the Rcs phosphorelay in the Enterobacteriaceae". Thesis, University of Bath, 2006. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436882.
Djeghdir, Inès. "Identification et caractérisation de facteurs de transcription appartenant à la famille des régulateurs de réponse de type B, impliqués dans la réponse à la sécheresse chez le peuplier". Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2056/document.
Plants are increasingly faced with a decrease in soil’s water availability, leading to a hydric and osmotic stress and impacting on their survival. Plant tolerance to this stress will be dependent on its perception. One of the signaling mechanisms related to this stress is called MultiStep Phosphorelay (MSP) and is composed by 3 partners: a histidine-aspartate receptor kinase (HK), histidine phosphotransfer proteins (HPt) and response regulators (RR), including the B-type RR transcription factors. In Arabidopsis, an MSP with AHK1, AHP2 and ARR18 has been identified for osmotic stress signaling. For poplar, HK1a and b, paralogous genes and homologous with AHK1, 10 HPt and 9 B-type RR genes have been isolated respectively. The osmosensor function of HK1a was proposed, and an osmosensing signaling pathway composed by HK1a, 3 HPt proteins, and 6 B-type RR has been suggested. The purpose of this work was focused on the identification and characterization of B-type RR transcription factors specifically linked to osmotic stress in poplar. The main results of this work are the highlight of the transcription factor function of two B-type RR, RR13 and RR19, through the study of their ability to dimerize and transactivate or not osmotic stress-responsive genes. The RR13 seems to be specific for cytokinins signaling pathway, whereas the RR19 seems to be specific for the osmosensing one. This work strongly supports the involvement of RR19 in the osmosensing MSP. Many studies have also been initiated during this work and will facilitate the characterization of the studied MSP
Borland, Stéphanie. "Rôle des systèmes à deux composants dans l’adaptation de la bactérie phytostimulatrice Azospirillum à la rhizosphère". Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10037.
Bacterial two-component systems play an important role in the ability of bacteria to adapt to various environments. The aim of this thesis was to identify and characterize two-component systems involved in the adaptation of the phytostimulatory bacteria Azospirillum to its host plant. Analysis of the genomic distribution of genes encoding two-component systems across Azospirillum available genomes revealed the existence of a high number of genes encoding hybrid histidine kinases, and further analyses highlighted a complex multi-domain organization of this family of proteins. In order to understand their role in Azospirillum, as a first step we selected and inactivated four genes encoding complex hybrid histidines kinases. Using a multidisciplinary approach which combines genetics, biochemistry and phylogeny, we brought to light for the first time in Azospirillum, an atypical three-component system named PreSKR which controls a wide variety of processes involved in survival and rhizosphere colonization likely by modulating c-di-GMP levels. As a second step, we focused on a gene encoding a hybrid histidine kinase named RsiK which is induced in contact with its host plant. RsiK is involved in surface sensing and biofilm formation regulation. Transcriptomic analysis of rsiK regulon by RNA-seq showed that 78 genes were under the control of this system. The prevalence of genes encoding hybrid histidine kinase family in Azospirillum, coupled with the functional characterization of two of them, highlight the importance of phosphorelays, still largely unrecognized in rhizospheric bacteria
Fernandez, Marion. "Le rôle de systèmes à phosphorelais dans l’infection de la puce Xenopsylla cheopis par Yersinia pestis". Thesis, Lille, 2019. http://www.theses.fr/2019LILUS050.
Two-component systems are used by bacteria to sense and respond to environmental cues by modulating genetic expression. They are composed of an histidine kinase, a sensor which transmits the signal to a response regulator by a phosphotransfert mechanism. Yersinia pestis is the causative agent of plague, a zoonotic disease, and is transmitted by fleas. Biofilm formation in the flea proventriculus leads to flea blockage, which is an important step for Y. pestis transmission by its vector. During its life cycle, Y. pestis must sense and adapt to different environments. This is why two-component systems have been considered of interest for Y. pestis pathogenicity studies. Our work provided evidence that OmpR/EnvZ is activated in the flea’s digestive tract. Interestingly, neither osmolarity nor pH variation in the flea gut trigger OmpR-EnvZ. In contrast, nutrient depletion occurring after blood digestion could be responsible for the activation of the system. We further reported that OmpR/EnvZ is needed for flea blockage because it is needed for biofilm formation in the proventriculus, especially by activating ompF. In addition to OmpR-EnvZ, we also provided evidence that the activation of the GlrKR-YfhG regulatory system is also required for flea blockage. Strikingly, this system displays two distinct function. In the proventriculus, it promotes the production of c-di-GMP, a secondary messenger essential for biofilm formation, and thus flea blockage. In the midgut, it activates the transcription of small RNA glmY and glmZ genes to maintain the bacterial morphology. Overall, our data suggest that the flea’s digestive tract is a toxic environment for Y. pestis and that the proventriculus and the midgut are two distinct environments
Sexauer, Anne [Verfasser], e Nicole [Akademischer Betreuer] Frankenberg-Dinkel. "Characterization of a bacterial-like signal transduction phosphorelay in Methanosarcina acetivorans / Anne Sexauer ; Betreuer: Nicole Frankenberg-Dinkel". Kaiserslautern : Technische Universität Kaiserslautern, 2021. http://d-nb.info/1237268974/34.
Chefdor, Françoise. "Recherche d’un phosphorelais multiple impliqué dans la perception et la transduction du signal stress hydrique chez le peuplier". Orléans, 2006. http://www.theses.fr/2006ORLE2054.
Capitoli di libri sul tema "Phosphorelays":
Perego, Marta, e James A. Hoch. "Two-Component Systems, Phosphorelays, and Regulation of Their Activities by Phosphatases". In Bacillus subtilis and Its Closest Relatives, 473–81. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555817992.ch33.
Hoch, James A. "spoO Genes, the Phosphorelay, and the Initiation of Sporulation". In Bacillus subtilis and Other Gram-Positive Bacteria, 747–55. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555818388.ch51.
Hoch, James A. "Control of Cellular Development in Sporulating Bacteria by the Phosphorelay Two-Component Signal Transduction System". In Two-Component Signal Transduction, 129–44. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555818319.ch8.
Hosoda, Kazuo, Etsuko Katoh, Tomohisa Hatta, Takeshi Mizuno e Toshimasa Yamazaki. "NMR Solution Structure of B-Motif, a Signature Motif of Type-B Response Regulators for His-to-Asp Phosphorelay Signal Transduction System, and Its Interactions with DNA". In Peptides: The Wave of the Future, 411–12. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0464-0_190.
Laub, Michael T., Emanuele G. Biondi e Jeffrey M. Skerker. "Phosphotransfer Profiling: Systematic Mapping of Two‐Component Signal Transduction Pathways and Phosphorelays". In Methods in Enzymology, 531–48. Elsevier, 2007. http://dx.doi.org/10.1016/s0076-6879(07)23026-5.
"Phosphorelay". In Encyclopedia of Genetics, Genomics, Proteomics and Informatics, 1485. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_12759.
"Serine/Threonine Protein Kinase Phosphorelay Modules". In Encyclopedia of Molecular Pharmacology, 1409. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57401-7_300467.
Varughese, Kottayil I., Haiyan Zhao, Vidya Harini Veldore e James Zapf. "Sporulation Phosphorelay Proteins and Their Complexes: Crystallographic Characterization". In Methods in Enzymology, 102–22. Elsevier, 2007. http://dx.doi.org/10.1016/s0076-6879(06)22005-6.
Majdalani, Nadim, e Susan Gottesman. "Genetic Dissection of Signaling Through the Rcs Phosphorelay". In Methods in Enzymology, 349–62. Elsevier, 2007. http://dx.doi.org/10.1016/s0076-6879(07)23016-2.
Kaserer, Alla O., Babak Andi, Paul F. Cook e Ann H. West. "Kinetic Studies of the Yeast His-Asp Phosphorelay Signaling Pathway". In Methods in Enzymology, 59–75. Elsevier, 2010. http://dx.doi.org/10.1016/s0076-6879(10)71004-1.
Atti di convegni sul tema "Phosphorelays":
Lampoudi, Sotiria, Robin Hulbert, Corinne Williams, Peggy Cotter e Linda Petzold. "The development of a model of a bacterial phosphorelay signal transduction system". In 2006 Bio Micro and Nanosystems Conference. IEEE, 2006. http://dx.doi.org/10.1109/bmn.2006.330933.
Rapporti di organizzazioni sul tema "Phosphorelays":
Lers, Amnon, e Gan Susheng. Study of the regulatory mechanism involved in dark-induced Postharvest leaf senescence. United States Department of Agriculture, gennaio 2009. http://dx.doi.org/10.32747/2009.7591734.bard.