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Gonzalez-Rivas, Benigno, Mulualem Tigabu, Guillermo Castro-Marin e Per Christer Oden. "Dynamique des peuplements et distribution spatiale des semis et arbrisseaux de quatre essences de forêt tropicale sèche au Nicaragua". BOIS & FORETS DES TROPIQUES 302, n. 302 (1 dicembre 2009): 21. http://dx.doi.org/10.19182/bft2009.302.a20397.
Testo completoAbstract (sommario):
La variation temporelle des densités de semis et arbrisseaux de quatre essences en forêt tropicale sèche, Calycophyllum candidissimum, Cedrela odorata, Haematoxylon brasiletto et Gyroscarpus americanus, ainsi que l'hétérogénéité dans l'espace de leur régénération selon la pente du terrain et l'exposition des houppiers à l'ensoleillement direct ont été examinées dans le Refuge national de faune de Chacocente, au Nicaragua. Les données relatives à chaque individu de plus de 10 cm de hauteur et de moins de 5 cm de diamètre à hauteur de poitrine ont été enregistrées pendant trois années consécutives, de 2001 à 2003. La densité des semis et arbrisseaux était fortement variable suivant les essences et dans le temps. La densité moyenne des semis au cours des années de recensement s'est établie respectivement à 37, 20 et 4 individus sur 2 ha pour G. americanus, C. candidissimum et H. brasiletto. Aucune régénération n'a été observée pour C. odorata. De même, la densité moyenne des arbrisseaux sur une parcelle de 2 ha s'est établie respectivement à 55, 20 et 2 pour G. americanus, C. candidissimum et H. brasiletto. La variation de la densité des peuplements de semis et d'arbrisseaux était positive pour C. candidissimum, indiquant une régénération continue et avancée pour cette essence. Pour G. americanus et H. brasiletto, le peuplement de semis a baissé alors que celui des arbrisseaux a augmenté. Pour G. americanus et C. candidissimum, les densités de semis et d'arbrisseaux étaient variables selon la pente du terrain et l'exposition des houppiers à l'ensoleillement direct, avec pour conséquence une distribution par paquets de la régénération. Il a été conclu que la régénération naturelle pourrait ne pas suffire au maintien du stock souhaité de ces essences, et qu'il conviendrait de prendre des mesures de restauration immédiates afin de soutenir le processus de régénération naturelle. (Résumé d'auteur)
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Widodo, Arif Siaha, e Surti Wardani. "Pengaruh Promosi Dan Penetapan Harga Terhadap Keputusan Pembelian Produk Cendo". Jurnal Pemasaran Kompetitif 3, n. 2 (23 febbraio 2020): 62. http://dx.doi.org/10.32493/jpkpk.v3i2.4496.
Testo completoAbstract (sommario):
Abstract. This study aims to determine the effect of promotion on the purchase decision of PT Penta Valent Jakarta products, to find out the effect of price setting on the "purchase decision" of cendo product PT Penta Valent Jakarta" and to determine the silmultaneous effect of "promotion and price determination on the purcahse decision of cendo product "PT Penta Valent Jakarta". The "analysis method" is used multiple linear regression test, t test and F test. The population are all the consumers who use cendo product PT Penta Valent Jakarta and the sample size are "100 respondents". The results show a positive effect of promotion on the "purchase decision" of cendo PT Penta Valent Jakarta with a coefficient value of "equal to" 0.519 and t value > t table or 5.884> 1,660. Pricing has a positive effect on purchasing decisions with a coefficient value obtained "of 0.327" and t valuet > t table or 8.007 > 1,660. Promotion and price simultaneously have a positive and significant effect on purchasing decisions for cendo product PT Penta Valent Jakarta, with the equation Y = 7.210 + 0.519 X1 + 0.327 X2 and F value > F table that is 60,369> 3,090. Keywords:" Promotion; "Pricing; Purchase Decisions
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Saiev, Shamil, Leïla Bonnaud, Camilo Zúñiga, Philippe Dubois, David Beljonne, Juan Carlos Ronda, Virginia Cadiz e Roberto Lazzaroni. "Positive effect of functional side groups on the structure and properties of benzoxazine networks and nanocomposites". Polymer Chemistry 10, n. 38 (2019): 5251–64. http://dx.doi.org/10.1039/c9py00667b.
Testo completo
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Zou, B. S. "Penta-Quark Components in Baryons and Evidence at BES". International Journal of Modern Physics A 21, n. 27 (30 ottobre 2006): 5552–57. http://dx.doi.org/10.1142/s0217751x06034732.
Testo completoAbstract (sommario):
Some recent progresses in our understanding of penta-quark components in baryons is briefly reviewed. The diquark cluster picture for the penta-quark components in baryons gives a natural explanation not only to the empirical indications for a positive strangeness magnetic moment μs and positive strangeness radius of the proton but also the longstanding mass-reverse problem of N*(1535), N*(1440) and Λ*(1405) resonances as well as the unusual decay pattern of the N*(1535) resonance. Evidence supporting this picture from available BES data on J/ψ decays is pointed out.
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Rahmiati, Filda, Rendika Nugraha e Tasya Zahwa Prayoga. "Workshop on Tourism Service Quality for Tourist Satisfaction and Return Visits to Cikadu Tourism Village, Tanjung Lesung Buffer Zone". Asian Pacific Journal of Management and Education 6, n. 3 (20 novembre 2023): 30–44. http://dx.doi.org/10.32535/apjme.v6i3.1634.
Testo completoAbstract (sommario):
In the light of COVID-19 outbreak, the tourism industry has affected the most with a loss in visitor both in local and foreign. The popularity of village tourism has increased as it can significantly boost the local and regional economies. This study is a explatorary research with descriptive analysis approach takes the form of community service activity program that based on a penta-helix structure and featured a strategic steering stakeholder with the representatives from academics, volunteers, businesspeople, and local resident from Cikadu, Tanjung Lesung. This paper intend to identify the stakeholders involved and increase their knowledge towards penta-helix model in village to rbuild restart tourism. This study found that not all tourism stakeholders in Cikadu village aware of the penta-helix model due to a lack of synergy in maximizing their roles. However, the workshop program giving a positive response from tourism village stakeholder and they are capable using a cooperative strategy between the community and stakeholders to manage tourism during a pandemic. The Penta helix instilled both knowledge and a fervor for tourist village development in participants.
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Felmlee, Diane H., Chris Julien e Sara C. Francisco. "Debating stereotypes: Online reactions to the vice-presidential debate of 2020". PLOS ONE 18, n. 1 (25 gennaio 2023): e0280828. http://dx.doi.org/10.1371/journal.pone.0280828.
Testo completoAbstract (sommario):
The 2020 Vice-Presidential debate afforded the opportunity to examine online reactions toward a woman of color, Kamala Harris, and a white man, Mike Pence, as they vied for the same position. We collected tweets from the Twitter API related to Harris and Pence, mainly using neutral hashtags. We examined keywords for gender and race slurs and conducted a multivariate analysis of tweet sentiment. Gender and racial slurs surface in both Harris and Pence datasets, showcasing the insidious nature of sexist and racist stereotypes that seep into online conversations regarding a high-status job debate. As anticipated, tweets regarding Harris contained a higher proportion of racist and sexist curse words, highlighting greater levels of harassment and “intersectional,” multi-ethnic/gender attacks. Racial insults targeting Blacks or Asians were more negative than those associated with Whites. Unexpectedly, tweets related to Harris were more positive in average sentiment than those regarding Pence. Yet, there were significantly more retweets, and more negativity of retweets, relating to Harris than to Pence, underscoring the relatively widespread broadcasting of derogatory messages about Harris. Overall, we found that harassing messages toward the candidates reinforced traditional race and gender stereotypes and bolstered the status of those who posted negative content by attaining more retweets. Harassers routinely invoked well-worn, stereotypical insults in their attacks, especially when targeting a multiracial woman.
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Aji, Wahyu Trisno. "Penta Helix: Five Variable Elements of Strength in the Development of Taman Langit Tourism Village, Batu Layar District, West Lombok Regency". Empowerment: Jurnal Pengabdian pada Masyarakat 3, n. 2 (28 ottobre 2023): 65–76. http://dx.doi.org/10.51700/empowerment.v3i2.564.
Testo completoAbstract (sommario):
This research discusses the application of the penta helix model in the development of the Taman Langit tourist village in Bengkuang Hill, Bengkaung village, Gunungsari sub-district, West Lombok district, NTB. The penta helix model emphasizes the important role of five main actors, namely government, community, business people, media and academics, in building and developing tourism destinations. Harmonious collaboration between these five factors is considered very crucial for the smooth development of village tourism. In the context of the Taman Langit tourist village, the government has a role as a provider of tourism access and infrastructure, while the community and business people act as the main actors who run and develop village tourism. The media functions as a promotional tool, while historians provide direction, consultation and predictions regarding the development of village tourism. Through the penta helix approach, it is hoped that people from various sectors can enjoy the positive benefits resulting from the development of the Taman Langit tourist village. This research uses a type of library study (library research) with secondary data in the form of literature such as books, journals, magazines and websites that are relevant to the research. Key words: penta helix, sky garden, tourism
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Dutra, Delamar José Volpato. "2020, o ano da peste". Estudos Kantianos [EK] 9, n. 1 (10 luglio 2021): 185. http://dx.doi.org/10.36311/2318-0501.2021.v9n1.p185.
Testo completoAbstract (sommario):
Em sua TL, Kant suscita a questão: a vacinação atenta ou não contra o dever perfeito de não se suicidar? O texto apresenta os argumentos dos comentadores para uma resposta afirmativa ou negativa à pergunta posta por Kant. A hipótese do presente artigo é que os termos nos quais Kant apresentou a problemática permitem que a sua argumentação seja reconstruída, em face da evolução científica das vacinas nos quesitos de eficácia e de segurança, de tal forma que se poderia dar uma resposta positiva à questão por ele formulada.
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Muthia, Rahma, Baso Amang e Junaiddin Zakaria. "Pengaruh Motivasi, Lingkungan Kerja, Organizational Citizenship Behaviour terhadap Kepuasan Kerja Karyawan Pt. Pentel Siporio di Makassar". Journal on Education 5, n. 3 (13 febbraio 2023): 9077–93. http://dx.doi.org/10.31004/joe.v5i3.1707.
Testo completoAbstract (sommario):
This study aims to examine empirically the influence of motivation, work environment and organizational citizenship behavior on job satisfaction of PT Pentel Siporio employees in Makassar. The population used is employees of PT. Pentel Siporio in Makassar, who have worked for three consecutive years, namely in 2019, 2020 and 2021. With a total population of 105 people, samples were drawn based on the solving formula, finally 51 people were obtained. employees who were used as respondents. This research is a quantitative and qualitative research using primary data. The hypothesis test used is Multiple Linear Regression Analysis. Data is processed through the Statistical Product and Service Solution (SPSS) Program. The results of this study indicate that Motivation, Work Environment and Organizational Citizenship Behavior are based on the results of a Simultaneous test or testing simultaneously with the three variables Motivation (x1), Work Environment (X2) and Organizational Citizenship Behavior (x3), so the results have a positive and significant effect on job satisfaction Employees of PT. Pentel Siporio in Makassar.
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Atu, Laurentius Florido, e Yohanes Gekeng Koten. "Nilai - Nilai dalam Upacara Penti di Manggarai Ditinjau dari Perspektif Filsafat Moral Kant". Proceedings of The National Conference on Indonesian Philosophy and Theology 2, n. 2 (1 settembre 2024): 522–48. http://dx.doi.org/10.24071/snf.v2i2.8521.
Testo completoAbstract (sommario):
Each culture has various traditional ceremonies. Traditional ceremonies become one of the entities that perpetuate a culture. Each traditional ceremony has values that want to be preserved and taught to the followers of that culture. The Penti Ceremony in the Manggarai Community, Flores, NTT is one of the pedagogical cultural activities. There are many values to be taught in the ceremony. Therefore, this paper aims to examine the important values contained in the Penti ceremony from the perspective of Immanuel Kant's moral philosophy. This research uses a qualitative approach with ethnographic methods. The results of this study show that the Penti ceremony contains philosophical values that can be interpreted from the perspective of Kant's moral philosophy, such as harmony with God and others. These positive things are important to be raised in order to become material that can be taught to the younger generation through formal and informal schools, such as local content programs.
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Leach, RM, AC Davidson, MJ O'Doherty, M. Nayagam, A. Tang e NT Bateman. "Non-invasive management of fever and breathlessness in HIV positive patients". European Respiratory Journal 4, n. 1 (1 gennaio 1991): 19–25. http://dx.doi.org/10.1183/09031936.93.04010019.
Testo completoAbstract (sommario):
In a prospective study of 72 human immunodeficiency virus (HIV) positive patients presenting with fever and breathlessness, a non-invasive management protocol, incorporating a scanning technique using radioactively labelled diethylenetriamine penta acetate (DTPA) and sputum induction, was found to be highly sensitive and specific in the early detection of Pneumocystis carinii pneumonia (PCP). At presentation, the DTPA scan was abnormal in 34 of 36 cases of PCP, irrespective of smoking history, whilst the chest radiograph was diffusely abnormal in 21 cases. Sputum induction identified 7 of 14 patients with PCP in the first six months of its use and 7 of 10 patients over the last six months. The DTPA lung scan and induced sputum examination are non-invasive techniques which can be used to investigate out-patients. In combination they detected all cases of PCP at presentation, reduced the need for bronchoscopy, resulted in a low case fatality (5.4%) and reduced the need for admission.
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Hanny, Rissa, e Yuli Krisnawati. "Pengaruh Kualitas Produk Dan Harga Terhadap Keputusan Pembelian Ac Merek Daikin Pada PT Penta Mitra Aircon Karawaci". Excellent 9, n. 2 (27 gennaio 2023): 133–44. http://dx.doi.org/10.36587/exc.v9i2.1359.
Testo completoAbstract (sommario):
The development of the business world is currently running very rapidly, which creates increasingly fierce competition among entrepreneurs. Technological advances are so rapid in various aspects of human life. The purpose of this study is to examine how much influence product quality has on purchasing decisions for Daikin Brand AC at PT Penta Mitra Aircon Karawaci Tangerang. Quantitative research methods were used in this study, which is based on the philosophy of positivism to examine certain populations or samples. The population of this research is consumers of PT Penta Mitra Aircon as many as 156 customers with a slovin' calculation and a precision of 5 percent, obtained 112 respondents as the final sample. The analytical method uses multiple linear regression analysis. The results of the study prove empirically that the magnitude of the influence of product quality on purchasing decisions of Daikin brand air conditioners is proven to have significance and a positive direction both partially and simultaneously. These product quality and price factors make a strong contribution of 60.08 percent to the decision to purchase Daikin Brand AC at PT Penta Mitra Aircon Karawaci Tangerang. The price factor has the highest influence compared to the product quality factor
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Nagai, T., A. Uehara, M. Fukushima, M. Myochin, T. Fujii, N. Sato e H. Yamana. "Absorption spectra and cyclic voltammograms of uranium species in molten lithium molybdate–sodium molybdate eutectic at 550 ºC". Proceedings in Radiochemistry 1, n. 1 (1 settembre 2011): 151–55. http://dx.doi.org/10.1524/rcpr.2011.0028.
Testo completoAbstract (sommario):
AbstractAbsorption spectra of uranium species dissolved in molten lithium molybdate–sodium molybdate eutectic of 0.51Li2MoO4–0.49Na2MoO4 mixture at 550 ºC were measured by UV/Vis/NIR spectrophotometry, and their redox reactions were investigated by cyclic voltammetry. We found that the major ions of uranium species dissolved in the melt were uranyl penta-valent. After purging dry oxygen gas into the melt, penta-valent species were oxidized to the uranyl hexa-valent. In the cyclic voltammetry of the melt without uranium species, it was confirmed that the lithium-sodium molybdenum oxide compounds were deposited on the working electrode at the negative potential and the lithium molybdenum oxide compounds were deposited on the counter electrode at positive potential. When UO2 was dissolved into the melt, the reductive reaction of the uranium species was observed at the reductive potential of the pure melt. This suggests that the uranium species dissolved in the melts could be recovered as mixed uranium-molybdenum oxides by electrolysis.
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Vajer, Prashant, V. J. Zinzala, Narendra Singh, Sisodiya R. R., V. A. Patel e J. B. Vasave. "Evaluation of Extractants for Determination of Micronutrients in Soils of South Gujarat, India". International Journal of Plant & Soil Science 36, n. 2 (22 gennaio 2024): 1–8. http://dx.doi.org/10.9734/ijpss/2024/v36i24358.
Testo completoAbstract (sommario):
An experiment was conducted at Department of Soil Science and Agricultural Chemistry, Navsari Agricultural University during the year 2018-19. The methods of micronutrients determination were (i) extracted through diethylene triamine penta acetic acid (DTPA) (ii) extracted through ammonium bicarbonate- diethylene triamine penta acetic acid (AB-DTPA) (iii) extracted through Neubauer. The methods of micronutrients were evaluated through method validation parameters like linearity, sensitivity of instruments, precision and predictability. The available micronutrients determined from the sample soils were correlated with soil physico-chemical properties to know the relationship of these properties with available micronutrients. The linearity study of the series of micronutrients standard were measured through different methods of micronutrient determination. These measured values showed linear relationship with reference values. The coefficient of determination (R2) for all the methods was > 0.90. The precision was determined by relative standard deviation (RSD) (%) of different micronutrient methods which were in the range of 1.834 to 19.11 %. All the studied methods of copper, iron, zinc and manganese determination, AB-DTPA extractant method has highly significant and positive correlation with nutrient uptake by wheat on Microwave Plasma Atomic Emission Spectroscopy (MP-AES) instrument. Organic C and sand content of soil have positive correlation with micronutrients availability. While pH, EC, CEC, CaCO3, silt and clay content of soil have negative correlation with available micronutrients.
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Sarjito, Aris, e Ghazalie. "Analysis Good Governance of Corruption Eradication toward Penta Helix Model in Indonesia". New Challenges in Accounting and Finance 3 (aprile 2020): 14–28. http://dx.doi.org/10.32038/ncaf.2020.03.02.
Testo completoAbstract (sommario):
Transparency International released an annual report on the corruption perception index in 2018. The survey results of 180 countries showed a bad score because more than two-thirds scored less than 50. The highest score is 100, which means very clean or free of corruption, and the lowest is zero which means it is very corrupt. Indonesia must learn from New Zealand and Australia who have succeeded in helping improve the corruption perception index in their country, even though Indonesia's corruption perception index experienced an upward trend in 2014-2018. In an effort to analyze Good Governance in eradicating corruption in Indonesia, the researchers applied the Penta Helix Model, better known as the ABCGM concept, namely Academicians, Business, Community, Government, and Media to reduce the level of corruption in Indonesia. This research method is qualitative to investigate, find, describe, and explain the quality or features of social influences that cannot be explained, measured or described through a quantitative approach. The Penta Helix model is considered to have a positive influence in eradicating corruption.
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Mello, Gabrielli Thais de, Rafael Martins da Costa, Maria Alice Altenburg de Assis e Kelly Samara Silva. "Obesogenic behavior clusters associated with weight status among Brazilian students: a latent class analysis". Ciência & Saúde Coletiva 28, n. 7 (luglio 2023): 1949–58. http://dx.doi.org/10.1590/1413-81232023287.08612022.
Testo completoAbstract (sommario):
Abstract This study aimed to examine the association between clusters of physical activity (PA), diet, and television viewing (TV) with weight status among a representative sample of Brazilian students. Data from the National Health School-based Survey (PeNSE) 2015 were analyzed (n = 16,521; mean age 14.8, standard deviation 0.03 year). PA (minutes/week spent in leisure-time, and commuting to/from school), TV (hours/day), and weekly consumption of deep-fried empanadas, candies, sodas, ultra-processed foods, fast foods, green salads or vegetables, and fruits were self-reported on the validated PeNSE questionnaire. Latent class analysis defined behavior classes, and binary logistic regression assessed the association between clustering and weight status. Six classes’ types with positive and negative behaviors were identified. Adolescents belonging to the “low TV time and high healthy diet” class had higher chances of being overweight (including obesity) compared to their peers in the “moderate PA and mixed diet” class. No associations were found in the other clusters. Mixed classes with healthy and unhealthy behaviors characterized adolescents’ lifestyles and these profiles were related to weight status.
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Sukmawati, Nur Najibah, Lystiana Nurhayat Hakim, Tommy Hastomo, Purwanti Taman e Hana Lia. "(Im)politeness Strategies Used in Vice -Presidential Candidates Debate Between Mike Pence and Sen. Kamala Harris". IDEAS: Journal on English Language Teaching and Learning, Linguistics and Literature 10, n. 2 (1 gennaio 2023): 1735–43. http://dx.doi.org/10.24256/ideas.v10i2.2990.
Testo completoAbstract (sommario):
Politeness is necessary for the way people socialize. However, some people choose to communicate impolitely despite knowing that it’s inappropriate. This study aims to find out how people use impoliteness strategies in communication, and identify the impoliteness strategies used in the Vice-Presidential United States of Amerika candidates debate between Mike Pence and Sen. Kamala Harris on October 8th, 2020, while also figuring out the purpose of using these strategies in the debate. For this reason, to identify the use of impoliteness strategies, the researcher used Jonathan Culpeper's (2005) theory of impoliteness strategies and a qualitative approach to analyze the data. The data was taken from a YouTube video entitled “Full Debate: Vice President Mike Pence and Sen. Kamala Harris | WSJ” posted by the Wall Street Journal on October 8, 2020. The results of this study revealed that four out of five impolite strategies were used, with negative impoliteness as the most commonly used strategy. The other four strategies are bald on record impoliteness, positive impoliteness, negative impoliteness, and sarcasm and mock politeness. Meanwhile, withholding politeness was never used in the debate.
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Dimian, Caroline O., Michael J. O'Doherty, David Asboe, Christopher J. Page, Kate Entwisle e James S. Bingham. "Radioactively labelled diethylene triamine penta acetate lung scan in Pneum ocystis carinii pneumonia and asymptomatic HIV-positive patients". International Journal of STD & AIDS 8, n. 8 (1 agosto 1997): 482–88. http://dx.doi.org/10.1258/0956462971920622.
Testo completoAbstract (sommario):
The objective of this study is to establish normal ranges for the assessment of lung permeability, using 99mTc DTPA (diethylene triamine penta acetate) aerosol by measuring the half-time of transfer from the lung in asymptomatic HIV-positive patients. Also to audit the use of the test in the clinical management of outpatients with symptoms suggestive of Pneumocystis carinii pneumonia (PCP). A retrospective analysis of data from outpatients' notes for the audit of symptomatic patients, and prospective acquisition of 'normal' data for HIVpositive asymptomatic patients who were non-smokers and smokers was performed. Over a period of 8 years, DTPA scans were performed on 400 asymptomatic HIV-positive patients (121 non-smokers and 279 smokers) and 188 symptomatic HIV-positive patients with symptoms suggestive of PCP. A biphasic curve of transfer of 99mTc DTPA with a half-time of less than 4 min, was considered diagnostic of PCP. The mean half-times ( SEM) for asymptomatic non-smokers was 61.4 3 min and for smokers was 21.9 0.8 min. In the symptomatic patients, 106 were treated for PCP and in 97 (91.5%) of these, the transfer was biphasic. Of the remaining 82 patients with respiratory pathology other than PCP, 71 (86.6%) had normal scans. The results show that smokers may have abnormal baseline scans 16/ 279 (5.7%) and therefore a baseline scan before symptoms should be recorded or a higher false positive rate can be expected. The test is however highly sensitive for the detection of PCP and allows the attending physician to initiate PCP treatment without delay.
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Astuti, Wati Aris, e Nurlaelasari Nurlaelasari. "Pengaruh Arus Kas Bebas dan Profitabilitas terhadap Kebijakan Utang". TRIKONOMIKA 12, n. 1 (26 giugno 2013): 40. http://dx.doi.org/10.23969/trikonomika.v12i1.458.
Testo completoAbstract (sommario):
The decision to select the best source of funding for companies requiring careful analysis of company financial managers. Debt policyis one ofthe important funding decisions for companies that must always be considered so that the company’s financial statements to be optimal. Financial statements that will either enhance the reputation of the company that created the trust all stakeholders such as investors. Free cash flow and profitability is one of the ratios used to measure the financial performance of the company. On the basis of the phenomenon of the study aims to determine how much influence the free cash flow and profitability to debt policy on PT Intraco Penta Tbk (PT Inta).The method used in this research is descriptive and verification methods with quantitative approaches. The data used is the annual financial report of PT Inta for 7 years, from 2005 until 2011. The test statistic used is the calculation of Pearson correlation, multiple linear regression analysis with the classical assumptions. Results of analysis variables free cash flow and profitability have a significant effect and has a strong relationship with the positive direction of the debt policy on PT Intraco Penta Tbk.
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Septiana, Winda, e Gloria Angelita. "Seasoldier's Brand Activation Strategy in the Penta Helix Model (Spreading Environmentally Friendly Viruses at the Deep Extreme Indonesia Event)". Jurnal Mahardika Adiwidia 3, n. 1 (11 gennaio 2024): 57–69. http://dx.doi.org/10.36441/mahardikaadiwidi.v3i1.1913.
Testo completoAbstract (sommario):
Now many people are competing to do good for the environment, this positive thing is in the spotlight in the eyes of the world, namely regarding plastic waste. There are many laws and government regulations regarding waste, with retailers no longer providing single-use shopping bags and the effect of the Covid 19 pandemic has reduced the problem of waste a little. The Seasoldier Community, founded by Nadine Chandrawinata and Dinni Setianingrum, has dared to carry out a movement with various actions to spread environmentally friendly viruses to the community. One of them has been done at Deep Extream Indonesia. This research method uses a qualitative approach and the type of research is descriptive. This research aims to analyze the Brand Activation Strategy in the Penta Helix Model by spreading environmentally friendly viruses at the Deep Extream Indonesia 2023 event. This research raises a sense of care and awareness so that every individual lives by keeping the environment clean, healthy and becomes an inherent culture. Cleaning up trash is no longer an obstacle for society but a reward.Keywords: Brand Activation, Penta Helix Model, Environmentally Friendly Virus, Seasoldier, Deep Extream Indonesia.
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Aragão, Antônia Ivoneida, Antônio Carlos M. Seoane, Tereza Cristina Arcanjo Leal, Nilma Cintra Leal e Alzira Maria Paiva de Almeida. "Vigilância da peste no Estado do Ceará: 1990-1999". Revista da Sociedade Brasileira de Medicina Tropical 35, n. 2 (aprile 2002): 143–48. http://dx.doi.org/10.1590/s0037-86822002000200003.
Testo completoAbstract (sommario):
As atividades de vigilância sorológica da peste nos focos do Estado do Ceará detectaram elevação do número de animais indicadores/sentinela com anticorpos antipestosos a partir de 1995, com pico em 1997 evidenciando aumento da circulação do bacilo pestoso em todos os focos investigados. De um total de 110.725 amostras de soro obtidas de roedores (7.873) e carnívoros domésticos (102.852) analisadas pela técnica de hemaglutinação (HA) para detecção de anticorpos contra o antígeno F1 da Yersinia pestis, 905 revelaram-se positivas, sendo 15 de roedores (4 Rattus rattus e 11 Galea spp), 720 de cães e 170 de gatos. Dos 652 casos humanos suspeitos e contatos investigados apenas dois foram positivos pela HA e um terceiro paciente foi positivo por hemocultura. A cepa isolada revelou-se altamente patogênica para animais de laboratório e mostrou sensibilidade aos antimicrobianos usados no tratamento dos doentes.
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NIEDBALSKI, WIESŁAW. "Progress in vaccines against peste des petits ruminants virus". Medycyna Weterynaryjna 79, n. 02 (2024): 6747–2024. http://dx.doi.org/10.21521/mw.6747.
Testo completoAbstract (sommario):
Peste des petits ruminants (PPR) is a highly contagious and economically important viral disease of both domestic (goats and sheep) and wild small ruminants. Due to the devastating effect of this disease on livestock and livelihoods, the Food and Agriculture Organization of the United Nations (FAO) and the World Organization for Animal Health (WOAH) endorsed the Global Strategy for the Control and Eradication of PPR (PPR GCES) and launched the PPR Global Eradication Programme (PPR GEP) to eradicate PPRV by 2030. In order to achieve this goal, a potent, safe and efficacious live-attenuated PPR vaccine with long-lasting immunity is available for immunoprophylaxis. However, the live-attenuated PPR vaccines are thermolabile and require maintenance of an effective cold chain to deliver to the field. In addition, infected animals cannot be differentiated from vaccinated ones (DIVA). To overcome these limitations, some new generation PPR vaccines have been developed: poxvirus vaccine, positive and negative marker vaccine through reverse genetic approach, chimeric vaccine, anti-idiotypic vaccine, subunit vaccine, virus-like particles vaccine, edible vaccine and combined vaccines. Novel recombinant PPR DIVA vaccines were evaluated in goats for safety and efficacy, and all vaccinated animals were clinically protected against an intranasal PPRV challenge. Furthermore, newly developed ELISAs were capable of differentiating between infected and vaccinated animals. Therefore, these DIVA vaccines and the associated tests can facilitate the serological monitoring process and speed up global PPR eradication through vaccination.
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Rossi, Omar, Mariaelena Caboni, Aurel Negrea, Francesca Necchi, Renzo Alfini, Francesca Micoli, Allan Saul, Calman A. MacLennan, Simona Rondini e Christiane Gerke. "Toll-Like Receptor Activation by Generalized Modules for Membrane Antigens from Lipid A Mutants of Salmonella enterica Serovars Typhimurium and Enteritidis". Clinical and Vaccine Immunology 23, n. 4 (10 febbraio 2016): 304–14. http://dx.doi.org/10.1128/cvi.00023-16.
Testo completoAbstract (sommario):
ABSTRACTInvasive nontyphoidalSalmonella(iNTS) disease is a neglected disease with high mortality in children and HIV-positive individuals in sub-Saharan Africa, caused primarily by Africa-specific strains ofSalmonella entericaserovars Typhimurium and Enteritidis. A vaccine using GMMA (generalized modules for membrane antigens) fromS.Typhimurium andS.Enteritidis containing lipid A modifications to reduce potentialin vivoreactogenicity is under development. GMMA with penta-acylated lipid A showed the greatest reduction in the level of cytokine release from human peripheral blood monocytes from that for GMMA with wild-type lipid A. Deletion of the lipid A modification genesmsbBandpagPwas required to achieve pure penta-acylation. Interestingly, ΔmsbBΔpagPGMMA fromS.Enteritidis had a slightly higher stimulatory potential than those fromS.Typhimurium, a finding consistent with the higher lipopolysaccharide (LPS) content and Toll-like receptor 2 (TLR2) stimulatory potential of the former. Also, TLR5 ligand flagellin was found inSalmonellaGMMA. No relevant contribution to the stimulatory potential of GMMA was detected even when the flagellin protein FliC fromS.Typhimurium was added at a concentration as high as 10% of total protein, suggesting that flagellin impurities are not a major factor for GMMA-mediated immune stimulation. Overall, the stimulatory potential ofS.Typhimurium andS.Enteritidis ΔmsbBΔpagPGMMA was close to that ofShigellasonneiGMMA, which are currently in phase I clinical trials.
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Cianniello, D., A. Prudente, R. Caputo, M. Piezzo, M. Riemma, B. Savastano, S. Cocco et al. "PerTe: efficacy and safety of pertuzumab in “real life setting” for the neoadjuvant treatment of HER2-positive breast cancer patients". Annals of Oncology 28 (ottobre 2017): vi36. http://dx.doi.org/10.1093/annonc/mdx424.039.
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Hernández Peralta, Alejandro de Jesús, Juan Carlos Crudet Balderas, Jesabel Gómez Sánchez e Ivette Pérez Hernández. "Análisis de competitividad sistémica de las mypes bajo un enfoque de productividad, innovación e industria 4.0". Revista Relayn - Micro y Pequeñas empresas en Latinoamérica 5, n. 1 (20 aprile 2021): 7–31. http://dx.doi.org/10.46990/relayn.2021.5.1.20.
Testo completoAbstract (sommario):
El objetivo del presente es determinar la forma de medir la asociación y correlación del índice de productividad, lo grados de adopción de innovaciones y el uso del comercio electrónico de las mypes. Además, de un análisis de competitividad sistémico a partir de los resultados del cuestionario aplicado a 464 directores de las mypes de la región Córdoba, Yanga y Fortín utilizando en el periodo de inicio de la pandemia. Donde se comprobó la existencia de una relación positiva entre las variables sistémicas de la innovación y la productividad. Abstract The purpose of this investigative research is to understand how the application of ISO 2600 Standards influence productivity within micro and small enterprises located in the municipality of Veracruz, in the State of Veracruz, Mexico. With regards to the n)ythodology, the analysis of 502 enterprises was performed with the use of an instrument which was validated and integrated with 230 items in seven parts. To carry out this investigation, this research focused on questions 33 and 34 (Posada, Penta, & Aguilar, 2020). The results that were obtained tend to demonstrate the existence of a positive correlation mean; between the , application of ISO 26000 standards and productivity in micro and small enterprises.
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Hoerniasih, Nia, Achmad Hufad, Uyu Wahyudin, Elih Sudiapermana, Dadang Yunus e Cucu Sukmana. "Pentahelix Based Entrepreneurship Management at PKBM Asholahiyah". International Journal of Professional Business Review 7, n. 3 (31 ottobre 2022): e0616. http://dx.doi.org/10.26668/businessreview/2022.v7i3.e616.
Testo completoAbstract (sommario):
Purpose: This study aims to find out how to manage the entrepreneurial potential of the village with the method of building cross-stakeholder cooperation (penta helix), then to improve entrepreneurship skills in an effort to improve the welfare of rural communities. Theoretical Framework: The theoretical framework used is entrepreneurship theory, pentahelix theory and community learning center (PKBM). Design/Methodology/Approach: This study uses a quantitative approach, namely research based on assumptions, then determined several variables through the right research instruments. The number of respondents was 30 PKBM students. Findings: The results of the study show extraordinary results, meaning that the contributors have proven to benefit from this research, starting from the skill factor in mapping business capabilities, besides showing positive results, meaning that participants have proven to benefit from this research starting from the knowledge aspect of mapping business potential. , determination of marketing strategies, and business management techniques. Research, Practical & Social implications: The practical implication is that the program has succeeded in increasing participants' knowledge of the penta helix principle, the use of various media to market products, and the flow of entrepreneurial capital. loans for MSME development. Implications/Originality/Value: Furthermore, pentahelix-based entrepreneurial management has an impact on increasing the ability of entrepreneurship skills according to the entrepreneurial potential of the existing village, carried out systematically and sustainably, then managing appropriate marketing strategies, and business control techniques.
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Hörmann, Anton Amadeus, Maximilian Klingler, Christine Rangger, Christian Mair, Lieke Joosten, Gerben M. Franssen, Peter Laverman e Elisabeth von Guggenberg. "Effect of N-Terminal Peptide Modifications on In Vitro and In Vivo Properties of 177Lu-Labeled Peptide Analogs Targeting CCK2R". Pharmaceutics 15, n. 3 (28 febbraio 2023): 796. http://dx.doi.org/10.3390/pharmaceutics15030796.
Testo completoAbstract (sommario):
The therapeutic potential of minigastrin (MG) analogs for the treatment of cholecystokinin-2 receptor (CCK2R)-expressing cancers is limited by poor in vivo stability or unfavorable accumulation in non-target tissues. Increased stability against metabolic degradation was achieved by modifying the C-terminal receptor-specific region. This modification led to significantly improved tumor targeting properties. In this study, further N-terminal peptide modifications were investigated. Two novel MG analogs were designed starting from the amino acid sequence of DOTA-MGS5 (DOTA-DGlu-Ala-Tyr-Gly-Trp-(N-Me)Nle-Asp-1Nal-NH2). Introduction of a penta-DGlu moiety and replacement of the four N-terminal amino acids by a non-charged hydrophilic linker was investigated. Retained receptor binding was confirmed using two CCK2R-expressing cell lines. The effect on metabolic degradation of the new 177Lu-labeled peptides was studied in human serum in vitro, as well as in BALB/c mice in vivo. The tumor targeting properties of the radiolabeled peptides were assessed using BALB/c nude mice bearing receptor-positive and receptor-negative tumor xenografts. Both novel MG analogs were found to have strong receptor binding, enhanced stability, and high tumor uptake. Replacement of the four N-terminal amino acids by a non-charged hydrophilic linker lowered the absorption in the dose-limiting organs, whereas introduction of the penta-DGlu moiety increased uptake in renal tissue.
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Couacy-Hymann, Emmanuel, Kouramoudou Berete, Theophilus Odoom, Lamouni Habibata Zerbo, Koffi Yao Mathurin, Valère Kouame Kouakou, Mohamed Idriss Doumbouya et al. "The Spread of Peste Des Petits Ruminants Virus Lineage IV in West Africa". Animals 13, n. 7 (6 aprile 2023): 1268. http://dx.doi.org/10.3390/ani13071268.
Testo completoAbstract (sommario):
Monitoring the transboundary spread of peste des petits ruminants (PPR) virus is an essential part of the global efforts towards the eradication of PPR by 2030. There is growing evidence that Lineage IV is becoming the predominant viral lineage, replacing Lineage I and II in West Africa. As part of a regional investigation, samples collected in Burkina Faso, Côte d’Ivoire, Guinea and Ghana were screened for the presence of PPRV. A segment of the nucleoprotein gene from positive samples was sequenced, and phylogenetic analysis revealed the co-circulation of Lineage II and IV in Burkina Faso, Côte d’Ivoire and Guinea, and the identification of Lineage IV in Ghana. These data will be of importance to local and regional authorities involved in the management of PPRV spread.
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Czarny, T. L., A. L. Perri, S. French e E. D. Brown. "Discovery of Novel Cell Wall-Active Compounds Using PywaC, a Sensitive Reporter of Cell Wall Stress, in the Model Gram-Positive Bacterium Bacillus subtilis". Antimicrobial Agents and Chemotherapy 58, n. 6 (31 marzo 2014): 3261–69. http://dx.doi.org/10.1128/aac.02352-14.
Testo completoAbstract (sommario):
ABSTRACTThe emergence of antibiotic resistance in recent years has radically reduced the clinical efficacy of many antibacterial treatments and now poses a significant threat to public health. One of the earliest studied well-validated targets for antimicrobial discovery is the bacterial cell wall. The essential nature of this pathway, its conservation among bacterial pathogens, and its absence in human biology have made cell wall synthesis an attractive pathway for new antibiotic drug discovery. Herein, we describe a highly sensitive screening methodology for identifying chemical agents that perturb cell wall synthesis, using the model of the Gram-positive bacteriumBacillus subtilis. We report on a cell-based pilot screen of 26,000 small molecules to look for cell wall-active chemicals in real time using an autonomous luminescence gene cluster driven by the promoter ofywaC, which encodes a guanosine tetra(penta)phosphate synthetase that is expressed under cell wall stress. The promoter-reporter system was generally much more sensitive than growth inhibition testing and responded almost exclusively to cell wall-active antibiotics. Follow-up testing of the compounds from the pilot screen with secondary assays to verify the mechanism of action led to the discovery of 9 novel cell wall-active compounds.
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Cianniello, Daniela, Antonella Prudente, Roberta Caputo, Michela Piezzo, Maria Riemma, Beatrice Savastano, Stefania Cocco et al. "PerTe: Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer patients—Efficacy and safety of pertuzumab in “real life" setting." Journal of Clinical Oncology 36, n. 15_suppl (20 maggio 2018): e12654-e12654. http://dx.doi.org/10.1200/jco.2018.36.15_suppl.e12654.
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MUDUN, AYSE, SEHER UNAL, RIDVAN ILHAN, RECAI AKTAY, MISTEN DEMIRYONT e SEMA CANTEZ. "False-Positive Uptake of Tc-99m Penta-DMSA in Fibrous Dysplasia of Breast in a Patient With Medullary Carcinoma of Thyroid". Clinical Nuclear Medicine 19, n. 4 (aprile 1994): 364–65. http://dx.doi.org/10.1097/00003072-199404000-00023.
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Mohammed, Abde Aliy, Tesfaye Rufael Chibssa, Waktole Terfa, Fasil Aklilu, Delesa Damena, Redeat Belayneh e Menbere Kidane. "Isolation and Molecular Characterization of Peste des Petits Ruminants Virus from Outbreaks in Southern Ethiopia, 2020". Advances in Virology 2022 (29 maggio 2022): 1–7. http://dx.doi.org/10.1155/2022/5329898.
Testo completoAbstract (sommario):
Peste des petits ruminants (PPR) is one of the most important transboundary diseases of small ruminants. In this study, nasal and oral swabs (n = 24) were collected from sheep (n = 7) and goats (n = 17) with clinical signs in southern Ethiopia in March 2020. PPR virus was isolated on Vero dog cells expressing the signaling lymphocyte activation molecule (VDS) and screened using RT-qPCR. Positive samples were confirmed by conventional RT-PCR followed by sequencing of a partial nucleoprotein (N) gene segment. Results revealed that 54% (n = 13/24) of the tested samples were PPRV-positive Phylogenetic analysis revealed that the viruses belonged to lineage IV and lineage II. The lineage IV viruses were similar, although not identical, to other lineage IV viruses previously reported in Ethiopia and other East African countries while the lineage II viruses have been reported for the first time in Ethiopia showed a high nucleotide identity (99.06%) with the vaccine (Nigeria 75/1) that is currently used in Ethiopia for the prevention of PPR. Further investigations are therefore recommended in order to fully understand the true nature of the lineage II PPRVs in Ethiopia.
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Omondi, Immaculate, Alessandra Galiè, Nils Teufel, Agnes Loriba, Eunice Kariuki e Isabelle Baltenweck. "Women’s Empowerment and Livestock Vaccination: Evidence from Peste des Petits Ruminants Vaccination Interventions in Northern Ghana". Animals 12, n. 6 (12 marzo 2022): 717. http://dx.doi.org/10.3390/ani12060717.
Testo completoAbstract (sommario):
Healthy livestock provide meaningful opportunities to enhance women’s empowerment (WE) in low- and middle-income countries. Animal vaccines are important to keep livestock healthy and productive. However, gender-based restrictions limit women’s access to animal health services, thereby affecting the potential of livestock to enhance their empowerment. While growing empirical evidence reveals that women-controlled livestock (e.g., small ruminants) have important implications for WE and support better household nutrition outcomes, little empirical evidence exists from rigorous analyses of the relationship between WE and animal vaccines for women-controlled livestock species. Our analysis explores the relationship between WE and involvement with PPR vaccination in Ghana. Data collected using the Women’s Empowerment in Livestock Index (WELI) tool from 465 women and 92 men farmers (who keep goats) from northern Ghana, and analyzed using PLS-SEM, revealed a significant direct positive association between knowledge about animal health and PPR vaccines and a significant indirect positive association between access to PPR vaccines and empowerment. The empowerment of women goat farmers, as revealed by our model’s results for the relationship between empowerment and vaccine facets, was significantly represented by asset ownership and input into decisions concerning livestock. These study results reveal important considerations in designing effective and equitable livestock vaccine systems.
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Rahat, Samsor, e Khwaja Mir Islam Saeed. "Effects of the COVID-19 Pandemic on Routine Immunization Coverage—Afghanistan, 2020". Iproceedings 8, n. 1 (3 febbraio 2022): e36464. http://dx.doi.org/10.2196/36464.
Testo completoAbstract (sommario):
Background The COVID-19 pandemic has been declared the worst public health crisis in the world, with over 50 million global confirmed cases and 1,256,869 global deaths across 214 countries and territories as of November 9, 2020. Among 73 GAVI-eligible countries, 69 of them have reported COVID-19 cases; Indonesia, India, and Pakistan are the countries that comprise the highest number of cases. Afghanistan reported its first case of COVID-19 on February 24, 2020, in Herat province, which was an imported case who had a travel history from Iran. Afghanistan reported 42,092 confirmed cases and 1558 deaths as of November 9, 2020. During the COVID-19 pandemic, around 300,000 Afghans returned from Iran and Pakistan, and this overwhelmed the government’s attempts to control the outbreak. There is no specific treatment for COVID-19, and no vaccine has been introduced yet. However, the World Health Organization recommends some measures in order to decrease the spread of virus transmission, such as physical distancing, avoiding gatherings, closing schools and universities, wearing masks, and home quarantine. Despite the lockdown of cities, health service delivery remains open in Afghanistan during the COVID-19 pandemic. The reporting of confirmed cases remains low; only health facilities are reporting confirmed cases and deaths. Hospitals have begun to lose staff; health staff are not only becoming ill or dying, they are also not able to work under conditions with highly contaminated environments and health hazards. The reporting of COVID-19 data has been unreliable. At first, the government only managed 100 tests per day, and the majority of people did not have access to HFs for testing, which caused the virus to start spreading throughout the community. In a recent nationwide, population-based seroepidemiological study that the Ministry of Public Health conducted on July in 9 regions of Afghanistan, around 10 million people were affected by COVID-19. The total proportion of COVID-19–positive infections was 31.5%. The highest proportion of COVID-19–positive infections was in Kabul region (53%). The east region had the second highest proportion of COVID-19–positive infections, which was 43% (Ministry of Public Health, 2020). Routine immunization is a vital component in reducing morbidity and mortality and one of the top priorities for the Ministry of Public Health. The health facilities that provide EPI services remain open all over the country, but the outreach and mobile sessions have been mostly suspended due to the lockdown, and families have been unable to reach HFs due to restrictions. In Kenya, the EPI performance dropped by 20% in the second quarter of 2020. In addition, in Bangladesh, Penta-3 coverage was 50% lower in April 2020 compared to that in the same period in 2019. As per our review on the routine immunization coverage for Pakistan, the first case of COVID-19 in Pakistan was reported on February 26, 2020, and Pakistan reported 344,839 confirmed cases and 6977 deaths as of November 9, 2020. More than 1 million children had missed vaccine doses by July 1, 2020, in Pakistan. The immunization coverage decreased by 49% for Penta-3 during March to April 2020 when compared with that in 2019 for the same months in Pakistan. Generally, the immunization uptake dropped by more than half during the COVID-19 pandemic in Pakistan (GAVI, 2020). Objective The primary objective of this study is to analyze the data on how much the EPI performance dropped during the COVID-19 pandemic and to determine its impact on routine immunization coverage. The secondary objectives of this study are (1) to analyze the data from April, May, June, and July for 2019 and 2020 and compare the coverage of different antigens in this period; (2) to learn how much the coverage of routine immunization dropped due to the COVID-19 pandemic; and (3) to trend analyze Penta-3, Measles-1, and TT2+(PW) coverage from December 2019 to August 2020. Methods This was a descriptive analysis of secondary data that existed in the EPIMIS database at the national level. The EPIMIS database is a part of the HMIS at the Ministry of Public Health. It was developed in 2015, and it is used as a data collection and extraction tool at the national and provincial levels. We extracted routine immunization data from the EPIMIS database from April to July of both 2019 and 2020 for comparison. In addition, we reviewed the trend analysis conducted from December 2019 to August 2020 that compared the four months prior to the lockdown (from December 2019 to March 2020) with the COVID-19 lockdown period (from April to July 2020). We managed and analyzed the data by using Microsoft Excel 2016 and Epi Info 7.2. Results Data for the main EPI indicators were analyzed at the national and provincial levels. As shown in our graph, the routine immunization coverage dropped by 11%, 2%, and 12% for Penta-3, Measles-1, and TT2+(PW), respectively, during the COVID-19 pandemic lockdown period (April to July 2020) when compared to those in 2019 for the same period. During the lockdown, the supplementary immunization activities for polio eradication nationwide, which were scheduled for May and June, were postponed as well. However, the coverage for OPV-3 decreased by 6% during the lockdown when compared with that in the same period of last year. The table shows the dropped percentages of all antigens from April to July of 2020 compared to those in the same period in 2019. This high drop in coverage was observed for TT2+(PW) and Penta-3. Moreover, coverage at the provincial level also decreased due to the COVID-19 pandemic. The highest decrease in coverage for Penta-3 and Measles-1—45% and 43%, respectively—was observed in Paktya province during the COVID-19 pandemic (compared to those in the same period in 2019). In addition, the highest TT2+ coverage for pregnant women was observed in Kunduz province, which dropped by 67%. During the lockdown, almost 200 HFs were closed, and the provision of fixed, outreach, and mobile sessions were limited due to COVID-19. The number of fixed sessions declined by 3%, while the number of outreach sessions declined by 1% during the lockdown period. Overall, 202,408 children in fixed sessions and 24,173 children in mobile sessions were missed during the lockdown period due to COVID-19 when compared to those in the same period in 2019. This decline was observed for Penta-3, Measles-1, and TT2+(PW) coverage due to COVID-19. The trend analyses for Penta-3, Measles-1, and TT2+(PW) for December 2019 to August 2020 indicates that the coverage of routine immunization slightly declined from April to July 2020 when compared to that in the months prior to the lockdown period. Based on the trend analyses, immunization coverage started to resume in July 2020. Conclusions Compared to the regional countries in which the EPI performance dropped by a high percentage, routine immunization coverage in Afghanistan dropped by 11% for Penta-3 and by 2% for Measles-1 during the lockdown period due to COVID-19. This reveals that the Afghanistan EPI team performed better during a crisis than lower-middle–income countries. However, there is a need for proper planning to protect essential health services during emergencies. In addition, the performance of fixed and outreach sessions for EPI activities declined by 3% and 1%, respectively, during the lockdown, which had a minor impact on routine immunization activities.
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Liu, Yu-Liang, Hai-Bin Zhu, Mai-Lin Chen, Wei Sun, Xiao-Ting Li e Ying-Shi Sun. "Prediction of the lymphatic, microvascular, and perineural invasion of pancreatic neuroendocrine tumors using preoperative magnetic resonance imaging". World Journal of Gastrointestinal Surgery 15, n. 12 (27 dicembre 2023): 2809–19. http://dx.doi.org/10.4240/wjgs.v15.i12.2809.
Testo completoAbstract (sommario):
BACKGROUND Significant correlation between lymphatic, microvascular, and perineural invasion (LMPI) and the prognosis of pancreatic neuroendocrine tumors (PENTs) was confirmed by previous studies. There was no previous study reported the relationship between magnetic resonance imaging (MRI) parameters and LMPI. AIM To determine the feasibility of using preoperative MRI of the pancreas to predict LMPI in patients with non-functioning PENTs (NFPNETs). METHODS A total of 61 patients with NFPNETs who underwent MRI scans and lymphadenectomy from May 2011 to June 2018 were included in this retrospective study. The patients were divided into group 1 (n = 34, LMPI negative) and group 2 (n = 27, LMPI positive). The clinical characteristics and qualitative MRI features were collected. In order to predict LMPI status in NF-PNETs, a multivariate logistic regression model was constructed. Diagnostic performance was evaluated by calculating the receiver operator characteristic (ROC) curve with area under ROC, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy. RESULTS There were significant differences in the lymph node metastasis stage, tumor grade, neuron-specific enolase levels, tumor margin, main pancreatic ductal dilatation, common bile duct dilatation, enhancement pattern, vascular and adjacent tissue involvement, synchronous liver metastases, the long axis of the largest lymph node, the short axis of the largest lymph node, number of the lymph nodes with short axis > 5 or 10 mm, and tumor volume between two groups (P < 0.05). Multivariate analysis showed that tumor margin (odds ratio = 11.523, P < 0.001) was a predictive factor for LMPI of NF-PNETs. The area under the receiver value for the predictive performance of combined predictive factors was 0.855. The sensitivity, specificity, PPV, NPV and accuracy of the model were 48.1% (14/27), 97.1% (33/34), 97.1% (13/14), 70.2% (33/47) and 0.754, respectively. CONCLUSION Using preoperative MRI, ill-defined tumor margins can effectively predict LMPI in patients with NF-PNETs.
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Ke, Dangyang, e Michael Boersig. "Sensory and Chemical Analyses of Tomato Flavor". HortScience 31, n. 4 (agosto 1996): 599b—599. http://dx.doi.org/10.21273/hortsci.31.4.599b.
Testo completoAbstract (sommario):
Consumer acceptance of sensory quality was significantly correlated (P = 0.05) with overall eating quality of tomatoes (Lycopersicon esculentum Mill.) determined by a trained taste panel. The overall eating quality was partitioned into three flavor components (sweetness, sourness, and aroma) and internal texture. Relationships between the sensory flavor components and concentrations of several chemical compounds were analyzed in tomatoes of eleven varieties within a range of acceptable texture. Sweetness was significantly correlated with total sugar concentration and overall flavor at P = 0.01 and 0.001. High concentrations of two ketone volatiles (6-methyl-5-hepten-2-one and 1-penten-3-one) were significantly correlated with aroma and overall flavor at P = 0.05 to 0.001. This study indicates that positive tomato flavor may be characterized by high sweetness, moderate acidity, and high concentrations of certain ketone volatiles.
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Da Silva Santos, Ane Francielly, e José Roberto Da Silveira Maia. "ANTIMICROBIAL EFFECT OF ORGANOTIN COMPOUNDS DERIVED FROM PHENOLIC SCHIFF BASES". Journal of Engineering and Exact Sciences 5, n. 5 (20 dicembre 2019): 0452–59. http://dx.doi.org/10.18540/jcecvl5iss5pp0452-0459.
Testo completoAbstract (sommario):
Several organotin(IV) derivatives of phenolic Schiff bases were prepared and investigated by spectroscopic methods. These compounds were bioassayed to evaluate their bacterial effect against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli and Salmonella typhimurium) microorganisms. Dimeric and monomeric compounds were characterized by infrared in solid state. Metallic centers having penta-, hexa-, and heptacoordination were identified by multinuclear NMR (1H, 13C and 119Sn) in solution. The di- and triorganotin(IV) derivatives were also investigated by conductimetric measurements in methanol, elemental analysis and melting point. The bioassay of these tin(IV) compounds showed that the best resulting activity was against S. aureus for the triphenyltin(IV) phenolic Schiff base derivatives, presenting MICs of 1.1 µM (0.6 mg mL-1) and 2.2 µM (1.3 mg mL-1).
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Perik, Patrick J., Marjolijn N. Lub-De Hooge, Jourik A. Gietema, Winette T. A. van der Graaf, M. Alexander de Korte, Sharon Jonkman, Jos G. W. Kosterink et al. "Indium-111–Labeled Trastuzumab Scintigraphy in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer". Journal of Clinical Oncology 24, n. 15 (20 maggio 2006): 2276–82. http://dx.doi.org/10.1200/jco.2005.03.8448.
Testo completoAbstract (sommario):
Purpose The cardiac and antineoplastic effects of trastuzumab may be related to specific uptake of trastuzumab in myocardium and tumor tissue, respectively. We evaluated whether indium-111 (111In) –labeled trastuzumab scintigraphy can predict cardiotoxicity and identify tumor lesions. In addition, we evaluated whether plasma markers for cardiac dysfunction can be used to predict cardiotoxicity. Patients and Methods Patients with human epidermal growth factor receptor 2 (HER2) –positive metastatic breast cancer underwent gamma camera imaging from 15 minutes to 7 days after injection of 150 MBq 111In–diethylenetriamine penta-acetic acid anhydride (DTPA) –trastuzumab, after loading-dose trastuzumab, and after once-a-week trastuzumab doses for 11 weeks, and concomitant paclitaxel once every 3 weeks. Cardiac assessments were performed before treatment, and after four and six cycles. Plasma N-terminal probrain natriuretic peptide (NT-proBNP) and serum troponin I were measured with immunoassay. Results Fifteen of the 17 patients were available for cardiac and tumor uptake analysis. On the first scan, myocardial 111In-DTPA-trastuzumab uptake was observed in one patient with pre-existing cardiac arrhythmias, who did not develop heart failure during treatment. Severe cardiotoxicity occurred in three patients, without initial myocardial uptake, whereas one showed weak myocardial uptake after four cycles. The detection rate of single tumor lesions was 45%. New tumor lesions were discovered in 13 of 15 patients. Pretreatment plasma NT-proBNP levels were higher in patients with than without heart failure (mean, 534 [standard deviation, 236] v 105 [standard deviation, 79] ng/L; P = .009). Conclusion Radiolabeled trastuzumab scintigraphy was not valuable in predicting trastuzumab-related cardiotoxicity in metastatic breast cancer patients, but can identify HER2-positive tumors. Measurement of plasma NT-proBNP is promising regarding prediction of trastuzumab-related cardiotoxicity.
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Dorais, Louis-Jacques. "Discours et identité à Iqaluit après l’avènement du Nunavut". Études/Inuit/Studies 30, n. 2 (7 febbraio 2008): 163–89. http://dx.doi.org/10.7202/017570ar.
Testo completoAbstract (sommario):
Résumé En examinant les résultats d’entrevues effectuées à Iqaluit en 2003 avec 35 personnes d’origine inuit, cet article tente de mettre en lumière les perceptions des répondants quant à la situation langagière dans le Nord après la création du Nunavut. L'article cherche à répondre à deux questions principales: 1) Croit-on que la valeur pratique de l’inuktitut — en tant qu’outil donnant accès au pouvoir social et politique, au marché du travail et au monde extérieur — a augmenté (ou est en voie d’augmentation) depuis la création du Nunavut? 2) Pense-t-on que le comportement langagier (plus particulièrement le choix entre l’inuktitut et l’anglais) a changé ou devrait changer suite à l’avènement du Nunavut? L'analyse des entrevues permet de conclure à l'apparition à Iqaluit d'un marché linguistique alternatif au sein duquel l'inuktitut possède une valeur fortement positive.
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Antier, Guilhen. "La chute de l’éternel dans le temps chez Kierkegaard : kénose et temporalité". Dossier 67, n. 1 (9 agosto 2011): 57–67. http://dx.doi.org/10.7202/1005488ar.
Testo completoAbstract (sommario):
Examinant la manière dont Kierkegaard pense l’articulation des notions de « temps » et d’« éternel » dans trois de ses ouvrages pseudonymes consacrés, sous des modalités et dans des styles divers, au thème central du christianisme — l’incarnation —, cette contribution tente de développer une compréhension de la kénose qui permette de remettre en perspective la temporalité historique et la condition de finitude propres à l’humain. On part d’un questionnement sur le rapport entre foi et histoire et sur le type de vérité auquel on a affaire dans le champ théologique. On poursuit par une réflexion qui s’efforce de rendre possible une réinterprétation positive de la notion aujourd’hui malmenée de « toute-puissance de Dieu ». On conclut en indiquant quelques retombées de la dialectique paradoxale entre temps et éternel, kénose et toute-puissance, sur le plan d’une éthique de la temporalité.
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Hosny, Wafaa Abd El Wahab, Eman Mohamed Baheeg, Hala Abd El Raheem Aly, Samia Said Abd El Nabi e Nadia Maher Hanna. "Field serological investigation for peste des petits ruminants, foot-and-mouth disease, and bluetongue diseases in illegally introduced animals in Egypt". August-2020 13, n. 8 (2020): 1661–66. http://dx.doi.org/10.14202/vetworld.2020.1661-1666.
Testo completoAbstract (sommario):
Aim: In this study, laboratory scoping on the viruses that cause peste des petits ruminants (PPR), bluetongue (BT), and foot-and-mouth disease (FMD) was performed to evaluate the current status of animals illegally introduced into Egypt. This study aims to help control these infectious illnesses and tries to prevent the introduction of other strains of these three viruses to Egypt, as these illnesses spread quickly if not controlled. Materials and Methods: In the year 2018, 62 serum samples were collected and serologically tested through competitive enzyme-linked immunosorbent assays (ELISA) kits to detect antibodies against PPR, BT, and FMD, which are three important transboundary infectious illnesses. Results: The results indicated that 60 out of 62 serum samples were positive for PPR antibodies (96.7%), 31 out of 62 were positive for FMD antibodies (50%), and 59 out of 62 serum samples were positive for BT antibodies (95%). Conclusion: This study revealed that PPR, FMD, and BT can be introduced into Egypt through the illegal introduction of sheep and goat from neighboring countries. Laboratory diagnostic abilities should be improved for the early detection and control of these illnesses.
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Choi, Kang-Seuk, Jin-Ju Nah, Young-Joon Ko, Shien-Young Kang e Nam-In Jo. "Rapid Competitive Enzyme-Linked Immunosorbent Assay for Detection of Antibodies to Peste des Petits Ruminants Virus". Clinical Diagnostic Laboratory Immunology 12, n. 4 (aprile 2005): 542–47. http://dx.doi.org/10.1128/cdli.12.4.542-547.2005.
Testo completoAbstract (sommario):
ABSTRACT Peste des petits ruminants (PPR) is a contagious viral disease of small ruminants that is of economic importance in Africa, the Middle East, and Asia. We developed a rapid competitive enzyme-linked immunosorbent assay (rapid c-ELISA) for the diagnosis and surveillance of PPR. This assay detects PPR virus (PPRV) antibodies in serum samples by quantifying the amount of monoclonal antibody (MAb) P-3H12 after 30 min of incubation of a serum-MAb conjugate mixture on plates coated with a PPRV recombinant nucleocapsid protein (rPPRV-N). We tested 249 PPRV-positive serum samples and 733 PPRV-negative serum samples from field ruminants. The threshold of percent inhibition (PI) was determined to be <50 on the basis of the mean PI plus 3 standard deviations for sera from PPRV-negative ruminants. The relative specificity and sensitivity of the rapid c-ELISA were 98.5% (722 of 733 serum samples) and 93.4% (234 of 249 serum samples), respectively. The rapid c-ELISA sensitively detected PPRV antibodies in hyperimmune sera (virus neutralization test [VNT] titer, >512), even at dilutions ≥512 in normal goat serum, and as early as 6 to 13 days postinfection from 12 goats, each of which was infected with one of the four PPRV lineages. Hyperimmune sera from animals experimentally vaccinated with rinderpest virus gave positive results by the rapid c-ELISA when the rinderpest virus VNT titers were >512, although the rapid c-ELISA titers were very low (2 to 16). However, the rapid c-ELISA was negative when the rinderpest virus VNT titer was ≤128. The rapid c-ELISA developed in the present work provides a short turnaround time and could be a useful tool for the diagnosis of PPR and screening for PPRV in the field.
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Ts., Undrakhbayar, Uuganbayar E. e Odbileg R. "SERO-SURVEILLANCE OF “PESTE DES PETITS RUMINANTS” PPR IN MONGOLIA AND DEVELOPMENT OF RECOMMENDATION". Mongolian Journal of Agricultural Sciences 19, n. 3 (10 gennaio 2017): 22–26. http://dx.doi.org/10.5564/mjas.v19i3.731.
Testo completoAbstract (sommario):
PPR (Peste des Petits Ruminants) is a transboundary disease, listed in the OIE Terrestrial Animal Health Code, which Mongolia and other countries are obligated to report the disease to the OIE according to the criteria [1]. Purpose of this study is to conduct sero-epidemiological survey for detection of PPR antibody in livestock and susceptible animals from aimag, soums near border area because 244 outbreaks have been recorded [2] in China mainland since September, 2013. A total of 1950 goat and sheep serum samples from 52 soums of 15 aimags have been examined by “ID VET” Competitive ELISA kit for antibody detection. Result showed that PPR virus antibodies have been found in 12 samples from 1550 sheep, and 4 samples from 400 goat samples which have been examined. The same result has been shown after the re-testing the positive samples by ELISA with the serum titration of 1:4 and 1:8. PPR Global strategy for prevention, control and eradication of PPR by 2030, has been developed by OIE and FAO [14]. PPR recommendation has been developed in accordance with the Global strategy and sero-surveillance conducted in Mongolia.
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Mdetele, Daniel Pius, Erick Komba, Misago Dimson Seth, Gerald Misinzo, Richard Kock e Bryony Anne Jones. "Review of Peste des Petits Ruminants Occurrence and Spread in Tanzania". Animals 11, n. 6 (7 giugno 2021): 1698. http://dx.doi.org/10.3390/ani11061698.
Testo completoAbstract (sommario):
Peste des petits ruminants (PPR) is an important transboundary animal disease of domestic small ruminants, camels, and wild artiodactyls. The disease has significant socio-economic impact on communities that depend on livestock for their livelihood and is a threat to endangered susceptible wild species. The aim of this review was to describe the introduction of PPR to Tanzania and its subsequent spread to different parts of the country. On-line databases were searched for peer-reviewed and grey literature, formal and informal reports were obtained from Tanzanian Zonal Veterinary Investigation Centres and Laboratories, and Veterinary Officers involved with PPR surveillance were contacted. PPR virus (PPRV) was confirmed in northern Tanzania in 2008, although serological data from samples collected in the region in 1998 and 2004, and evidence that the virus was already circulating in Uganda in 2003, suggests that PPRV might have been present earlier than this. It is likely that the virus which became established in Tanzania was introduced from Kenya between 2006–7 through the cross-border movement of small ruminants for trade or grazing resources, and then spread to eastern, central, and southern Tanzania from 2008 to 2010 through movement of small ruminants by pastoralists and traders. There was no evidence of PPRV sero-conversion in wildlife based on sera collected up to 2012, suggesting that they did not play a vectoring or bridging role in the establishment of PPRV in Tanzania. PPRV lineages II, III and IV have been detected, indicating that there have been several virus introductions. PPRV is now considered to be endemic in sheep and goats in Tanzania, but there has been no evidence of PPR clinical disease in wildlife species in Tanzania, although serum samples collected in 2014 from several wild ruminant species were PPRV sero-positive. Similarly, no PPR disease has been observed in cattle and camels. In these atypical hosts, serological evidence indicates exposure to PPRV infection, most likely through spillover from infected sheep and goats. Some of the challenges for PPRV eradication in Tanzania include movements of small ruminants, including transboundary movements, and the capacity of veterinary services for disease surveillance and vaccination. Using wildlife and atypical domestic hosts for PPR surveillance is a useful indicator of endemism and the ongoing circulation of PPRV in livestock, especially during the implementation of vaccination to control or eliminate the disease in sheep and goats. PPR disease has a major socio-economic impact in Tanzania, which justifies the investment in a comprehensive PPRV eradication programme.
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Tavares, Letícia Ferreira, Inês Rugani Ribeiro de Castro, Renata Bertazzi Levy, Letícia de Oliveira Cardoso e Rafael Moreira Claro. "Dietary patterns of Brazilian adolescents: results of the Brazilian National School-Based Health Survey (PeNSE)". Cadernos de Saúde Pública 30, n. 12 (dicembre 2014): 2679–90. http://dx.doi.org/10.1590/0102-311x00016814.
Testo completoAbstract (sommario):
The objectives of this study were to identify dietary patterns in Brazilian adolescents, describe their distributions in Brazil's State capitals and Federal District, and analyze the correlations with the Municipal Human Development Index (HDI-M). The study analyzed a sample of 60,954 ninth-graders from public and private schools who participated in the National School-Based Health Survey (PeNSE) in 2009. Cluster analysis was used to characterize dietary patterns. Three patterns were identified: healthy (27.7%), unhealthy (34.6%), and mixed (37.7%). Adolescents in the country's Southeast, South, and Central West regions showed a higher proportion of the healthy eating pattern. HDI-M showed a positive correlation with the healthy pattern and a negative correlation with the mixed pattern. The identification of different dietary patterns within and between regions and according to HDI-M highlights the need for better knowledge of each local context in terms of both the magnitude of events and the examination of determinants within these different realities.
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Werner, Christian. "FUTURO E PASSADO DA LINHAGEM DE FERRO EM TRABALHOS E DIAS: O CASO DA GUERRA JUSTA". Classica - Revista Brasileira de Estudos Clássicos 27, n. 1 (3 novembre 2015): 37. http://dx.doi.org/10.24277/classica.v27i1.91.
Testo completoAbstract (sommario):
Discute-se a representação da linhagem de ferro em Trabalhos e Dias de Hesíodo como um desafio poético e sapiencial que Hesíodo propõe a seu público a partir do passado consubstanciado em outras quatro linhagem e um futuro em aberto. O principal viés explorado é a linhagem dos heróis, pois ela não está de todo separada da de ferro. Ainda que a linhagem dos heróis tenha elementos que a caracterizem de forma positiva relativamente à linhagem de bronze, polemos como sua atividade por excelência a liga diretamente à cidade injusta e à Eris má. Assim, nem a linhagem dos heróis nem a de ouro são um futuro viável para a de ferro, mas servem para que o público do poema pense alternativas de futuro para sua própria época.
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Monopoli, Antonio, Giovanni Ventura, Andrea Aloia, Fulvio Ciriaco, Angelo Nacci, Tommaso R. I. Cataldi e Cosima D. Calvano. "Synthesis and Investigation of Novel CHCA-Derived Matrices for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometric Analysis of Lipids". Molecules 27, n. 8 (15 aprile 2022): 2565. http://dx.doi.org/10.3390/molecules27082565.
Testo completoAbstract (sommario):
A significant area of study and upgrading for increasing sensitivity and general performances of matrix-assisted laser-desorption ionization (MALDI) mass spectrometry (MS) is related to matrix design. Several efforts have been made to address the challenge of low-mass-region interference-free for metabolomics analysis and specifically for lipidomics. To this aim, rationally designed matrices as 4-chloro-α-cyanocinnamic acid (ClCCA) were introduced and reported to provide enhanced analytical performances. We have taken this rational design one step further by developing and optimizing new MALDI matrices with a range of modifications on the CHCA core, involving different functionalities and substituents. Of particular interest was the understanding of the electron-withdrawing (e.g., nitro-) or donating (e.g., methoxy-) effects along with the extent of conjugation on the ionization efficiency. In the present work, ten matrices were designed on a reasonable basis, synthesized, and characterized by NMR and UV spectroscopies and laser desorption ionization. With the assistance of these putative MALDI matrices, samples containing phospholipids (PL), and neutral di-/tri-acylglycerols (DAG, TAG) were investigated using milk, fish, blood, and human plasma extracts. In comparison with CHCA and ClCCA, four of them, viz. [(2E,4E)-2-cyano-5-(4-methoxyphenyl)penta-2,4-dienoic acid] (1), [(2E,4E)-2-cyano-5-(4-nitrophenyl)penta-2,4-dienoic acid] (2), [(E)-2-cyano-3-(6-methoxynaphthalen-2-yl)acrylic acid] (6) and [(E)-2-cyano-3-(naphthalen-2-yl)acrylic acid] (7) displayed good to even excellent performances as MALDI matrices in terms of ionization capability, interference-free spectra, S/N ratio, and reproducibility. Especially compound 7 (cyano naphthyl acrylic acid, CNAA) was the election matrix for PL analysis and matrix 2 (cyano nitrophenyl dienoic acid, CNDA) for neutral lipids such as DAG and TAG in positive ion mode.
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Schmitt, Anita, Junxia Yao, Hermann Einsele, Ulrich Grigoleit, Dirk Busch, Manuel Odendahl, Lothar Germeroth et al. "Streptamer Technology for the Assessment of CMVpp65 Specific CD8+ T Cell Frequencies and for the Adoptive T Cell Transfer to Post-Transplant Patients." Blood 110, n. 11 (16 novembre 2007): 1964. http://dx.doi.org/10.1182/blood.v110.11.1964.1964.
Testo completoAbstract (sommario):
Abstract Cytomegalovirus (CMV) reactivation constitutes a serious complication after allogeneic peripheral blood stem cell transplantation (PBSCT). The frequency of CMVpp65 specific CD8+ T cells is pivotal for the clearance of CMV. CMVpp65 specific CD8+ T cell frequencies can be measured using tetra-, penta- and streptamer technologies, streptamers can also be applied therapeutically. In donors, these frequencies might allow us to define the best available donor in addition to the mere serostatus. In the present study we investigated the specificity and sensitivity of all three methods and compared the results to the serostatus. A therapeutical application, i.e. an adoptive transfer of CMV specific CD8+ T cells selected by streptamer technology to a patient with acute lymphatic leukemia suffering from life-threatening CMV antigenemia after allogeneic PBSCT was performed. 23 samples from CMV seropositive healthy volunteers (HV) and 10 samples from CMV seropositive patients before and after allogeneic stem cell transplantation (all HLA-A2 or -B7 positive) were analyzed with tetra-, penta- or streptamer conjugated to PE by flow cytometry. Our lab took part in an inter-lab CMV multimer assay including 20 European countries in the framework of www.kimt.de. For the adoptive T cell transfer a donor leukapheresis was performed followed by an HLA-B7 CMVpp65 streptamer positive selection. The patient received 2×10E5 CMV specific CD8+ T cells per kg body weight as a single transfusion. Optimal amounts of HLA-A2 multimers to stain a pellet of 10E6 cells were 0.44 mcg tetramer, 0.15 mcg pentamer and 0.2 mcg MHC/0.3 mcg streptactin complex. Surprisingly, only in 48% (11/23) seropositive HV CD8+ multimer+ T cells could be detected. The ALL patient developed a foscarvir resistant CMV antigenemia with a maximum of 959/500,000 CMVpp65 positive cells. After a switch to ganciclovir/valganciclovir and an adoptive transfer of CMV specific T cells, the antigenemia was cleared. Valganciclovir was discontinued, but CMV antigenemia remained controlled. The frequency of CMVpp65 specific CD8+ T cells increased dramatically from 0.0% till 19.8%. All of these T cells were donor derived as demonstrated by small tandem repeat (STR) analysis. The patient did not develop signs of CMV disease at any time point. This study demonstrates the power of multimer staining to define appropriate donors for transplantation. Donors should be screened for their CMVpp65 specific CD8+ T cell frequency. All three multimer technologies can be used yielding similar results. The streptamer technology additionally offers the advantage to select CMVpp65 specific CD8+ T cells at the GMP level for adoptive T cell transfer and can induce long-lasting CD8+ T cell responses effectively clearing even a high virus load.
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Pestil, Zuleyha. "Molecular Epidemiology of Peste Des Petits Ruminants Cases Associated with Abortion in Sheep and Goat in Marmara Region of Turkey, 2018". Pakistan Veterinary Journal 40, n. 04 (1 dicembre 2020): 494–98. http://dx.doi.org/10.29261/pakvetj/2020.042.
Testo completoAbstract (sommario):
The aim of this study was to investigate the molecular epidemiology of peste des petits ruminants (PPR) infections associated with abortion in sheep and goat samples from the Marmara region of Turkey during 2018. The study was carried out from 116 sheep and 26 goat abortion cases. PPR virus (PPRV) detection in these samples was performed using real-time RT-PCR (Q-RT-PCR). Then, sequence analysis was performed from PPRV positive samples. Q-RT-PCR results demonstrated that 12 (10.34%) out of 116 sheep abortion samples and 3 (11.53%) out of 26 goat abortion samples were positive for PPRV genome. The sequence results of RT-PCR positive products revealed that the viruses causing the cases belong to lineage IV. Furthermore, molecular analysis showed that present cases were not related to PPRV vaccine strains or its mutants. Marmara region, where this study was conducted, is a neighbour of European countries such as Bulgaria and Greece. The first PPR cases in Europe were reported from Bulgaria at the beginning of 2018 and subsequently, other cases also reported before are mentioned in the present study. This study provides valuable information to understand the epidemiology of recently emerged PPRV cases in Europe and Turkey. Furthermore, because of the prevalence of PPRV in abortion samples in this study, these results suggest that PPRV may be one of the possible etiologic agents of abortions in sheep and goat. However, for clarification of the relationship between abortion and PPRV, there is need more robust epidemiological data and experimental infection studies
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Ratna Susanti, Suci Purwandari e Basnendar Herry Prilosadoso. "PENTA HELIX AS STRATEGY OF TOURISM VILLAGE DEVELOPMENT IN KARANGASEM VILLAGE, BULU DISTRICT, SUKOHARJO REGENCY". International Journal of Social Science 2, n. 4 (14 dicembre 2022): 1979–84. http://dx.doi.org/10.53625/ijss.v2i4.4261.
Testo completoAbstract (sommario):
This study aims to identify the integration of tourism development in Karangasem Village using the penta helix, which is a process of synergy between the five helices to support tourism in Karangasem Village. The five helics are academics, business, communities, media, and government. This study uses a qualitative descriptive method by applying the data collection techniques of Miles, Huberman, and Saldana, namely data condensation, data display, and drawing conclusions. The results of this study indicate that each stakeholder has their role in the development of a tourism village. The academics focus on training and mentoring for Pokdarwis members as well as tourism village managers regarding tourism village management and promotion strategies, the business sectors focus on increasing value and maintaining economic growth in the Karangasem tourism village, the community help to support and manage the tourism potential, the media help to publish news on tourism village branding as well as promotion, and the governments collaborate with academics to make policies of the management of tourism villages. The collaboration between the various actors involved government, community, business sector, academics and mass media can provide positive feedback in the concept of developing a tourism village in Karangasem Village.