Articoli di riviste sul tema "PCSK1"
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Parvaz, Najmeh, e Zahra Jalali. "Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss". PLOS ONE 16, n. 10 (28 ottobre 2021): e0259085. http://dx.doi.org/10.1371/journal.pone.0259085.
Testo completoGagnon, Jeffrey, Janice Mayne, Majambu Mbikay, John Woulfe e Michel Chrétien. "Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine". Regulatory Peptides 152, n. 1-3 (gennaio 2009): 54–60. http://dx.doi.org/10.1016/j.regpep.2008.07.006.
Testo completoXu, Xu, Egor Volcotrub e Svetlana B. Ten. "LBSUN131 Leptin Level, BMI And Genetics In Early Onset Obesity". Journal of the Endocrine Society 6, Supplement_1 (1 novembre 2022): A5. http://dx.doi.org/10.1210/jendso/bvac150.009.
Testo completoClément, Karine, Martin Wabitsch, Erica Van den Akker, Jesús Argente, Ceclila Scimia, Madhura Srinivasan, Guojun Yuan e Peter Kühnen. "ODP607 Long-term Efficacy of Setmelanotide in Patients With POMC or LEPR Deficiency Obesity". Journal of the Endocrine Society 6, Supplement_1 (1 novembre 2022): A14—A15. http://dx.doi.org/10.1210/jendso/bvac150.030.
Testo completoAerts, Laetitia, Nathalie A. Terry, Nina N. Sainath, Clarivet Torres, Martín G. Martín, Bruno Ramos-Molina e John W. Creemers. "Novel Homozygous Inactivating Mutation in the PCSK1 Gene in an Infant with Congenital Malabsorptive Diarrhea". Genes 12, n. 5 (10 maggio 2021): 710. http://dx.doi.org/10.3390/genes12050710.
Testo completoVelazquez-Roman, Jorge, Uriel A. Angulo-Zamudio, Nidia Leon-Sicairos, Hector Flores-Villaseñor, Miriam Benitez-Baez, Ana Espinoza-Salomón, Alejandra Karam-León et al. "Association of PCSK1 and PPARG1 Allelic Variants with Obesity and Metabolic Syndrome in Mexican Adults". Genes 14, n. 9 (8 settembre 2023): 1775. http://dx.doi.org/10.3390/genes14091775.
Testo completoAyers, Kristin L., Benjamin S. Glicksberg, Alastair S. Garfield, Simonne Longerich, Joseph A. White, Pengwei Yang, Lei Du et al. "Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment". Journal of Clinical Endocrinology & Metabolism 103, n. 7 (2 maggio 2018): 2601–12. http://dx.doi.org/10.1210/jc.2018-00258.
Testo completoVan Dijck, Evelien, Sigri Beckers, Sara Diels, Tammy Huybrechts, An Verrijken, Kim Van Hoorenbeeck, Stijn Verhulst, Guy Massa, Luc Van Gaal e Wim Van Hul. "Rare Heterozygous PCSK1 Variants in Human Obesity: The Contribution of the p.Y181H Variant and a Literature Review". Genes 13, n. 10 (27 settembre 2022): 1746. http://dx.doi.org/10.3390/genes13101746.
Testo completoMorash, Michael G., Angela B. MacDonald, Roger P. Croll e Younes Anini. "Molecular cloning, ontogeny and tissue distribution of zebrafish (Danio rerio) prohormone convertases: pcsk1 and pcsk2". General and Comparative Endocrinology 162, n. 2 (giugno 2009): 179–87. http://dx.doi.org/10.1016/j.ygcen.2009.03.013.
Testo completoSanders, SS. "PCSK1 variants: genetic risk factors for obesity". Clinical Genetics 75, n. 4 (aprile 2009): 318–19. http://dx.doi.org/10.1111/j.1399-0004.2009.01171_1.x.
Testo completoFarooqi, Sadaf, Jennifer Lynne Miller, Olga Ohayon, Guojun Yuan, Murray Stewart, Cecilia Scimia e Jack Yanovski. "Effects of Setmelanotide in Patients With POMC, PCSK1, or LEPR Heterozygous Deficiency Obesity in a Phase 2 Study". Journal of the Endocrine Society 5, Supplement_1 (1 maggio 2021): A669—A670. http://dx.doi.org/10.1210/jendso/bvab048.1367.
Testo completoClément, Karine, Erica L. T. van den Akker, Gregory Gordon, Guojun Yuan e Peter Kühnen. "Timing of Onset of Adverse Events With Setmelanotide, an MC4R Agonist, in Patients With Severe Obesity Due to LEPR or POMC Deficiency". Journal of the Endocrine Society 5, Supplement_1 (1 maggio 2021): A30—A31. http://dx.doi.org/10.1210/jendso/bvab048.058.
Testo completoWabitsch, Martin, Sadaf Farooqi, Jesús Argente, Erica van den Akker, Guojun Yuan, Olga Ohayon e Cecilia Scimia. "RF24 | PSUN96 Setmelanotide in Patients With Heterozygous POMC, LEPR, SRC1, or SH2B1 Obesity: Design of EMANATE – A Placebo-Controlled Phase 3 Trial". Journal of the Endocrine Society 6, Supplement_1 (1 novembre 2022): A37. http://dx.doi.org/10.1210/jendso/bvac150.076.
Testo completoFarooqi, Sadaf, Jennifer Miller, Olga Ohayan, Cecilia Scimia, Christopher Still, Marianne Yohn, Guojun Yuan, Jesús Argente e Brieana Buckley. "OR10-1 Body Mass Index and Weight Reductions in Patients With Obesity Due to Heterozygous Variants in POMC, PCSK1, and LEPR After 1 Year of Setmelanotide". Journal of the Endocrine Society 6, Supplement_1 (1 novembre 2022): A15. http://dx.doi.org/10.1210/jendso/bvac150.031.
Testo completoPickett, Lindsay A., Michael Yourshaw, Valeria Albornoz, Zijun Chen, R. Sergio Solorzano-Vargas, Stanley F. Nelson, Martín G. Martín e Iris Lindberg. "Functional Consequences of a Novel Variant of PCSK1". PLoS ONE 8, n. 1 (28 gennaio 2013): e55065. http://dx.doi.org/10.1371/journal.pone.0055065.
Testo completoHerrmann, G., M. Wabitsch e J. von Schnurbein. "Monogene Formen der Adipositas beim Menschen". Adipositas - Ursachen, Folgeerkrankungen, Therapie 12, n. 04 (dicembre 2018): 162–67. http://dx.doi.org/10.1055/s-0038-1676672.
Testo completoBenzinou, Michael, John W. M. Creemers, Helene Choquet, Stephane Lobbens, Christian Dina, Emmanuelle Durand, Audrey Guerardel et al. "Common nonsynonymous variants in PCSK1 confer risk of obesity". Nature Genetics 40, n. 8 (6 luglio 2008): 943–45. http://dx.doi.org/10.1038/ng.177.
Testo completoChrétien, Michel, e Majambu Mbikay. "60 YEARS OF POMC: From the prohormone theory to pro-opiomelanocortin and to proprotein convertases (PCSK1 to PCSK9)". Journal of Molecular Endocrinology 56, n. 4 (maggio 2016): T49—T62. http://dx.doi.org/10.1530/jme-15-0261.
Testo completoZheng, Xiaoya, Wei Ren, Suhua Zhang, Jingjing Liu, Sufang Li, Jinchao Li, Ping Yang, Jun He, Shaochu Su e Ping Li. "Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population". Molecular Biology Reports 39, n. 1 (25 marzo 2011): 17–23. http://dx.doi.org/10.1007/s11033-011-0705-6.
Testo completoStijnen, Pieter, Bruno Ramos-Molina, Stephen O'Rahilly e John W. M. Creemers. "PCSK1 Mutations and Human Endocrinopathies: From Obesity to Gastrointestinal Disorders". Endocrine Reviews 37, n. 4 (17 maggio 2016): 347–71. http://dx.doi.org/10.1210/er.2015-1117.
Testo completoRamos-Molina, Bruno, María Molina-Vega, José Fernández-García e John Creemers. "Hyperphagia and Obesity in Prader–Willi Syndrome: PCSK1 Deficiency and Beyond?" Genes 9, n. 6 (7 giugno 2018): 288. http://dx.doi.org/10.3390/genes9060288.
Testo completoGu, Q., M. Yazdanpanah, M. van Hoek, A. Hofman, X. Gao, F. W. M. de Rooij e E. J. G. Sijbrands. "Common variants in PCSK1 influence blood pressure and body mass index". Journal of Human Hypertension 29, n. 2 (17 luglio 2014): 82–86. http://dx.doi.org/10.1038/jhh.2014.59.
Testo completoFrank, Graeme R., Joyce Fox, Ninfa Candela, Zorica Jovanovic, Elena Bochukova, Jeremiah Levine, Peter R. Papenhausen, Stephen O'Rahilly e I. Sadaf Farooqi. "Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency". Molecular Genetics and Metabolism 110, n. 1-2 (settembre 2013): 191–94. http://dx.doi.org/10.1016/j.ymgme.2013.04.005.
Testo completoChang, Yi-Cheng, Yen-Feng Chiu, Kuang-Chung Shih, Ming-Wei Lin, Wayne Huey-Herng Sheu, Timothy Donlon, Jess David Curb et al. "Common PCSK1 Haplotypes Are Associated With Obesity in the Chinese Population". Obesity 18, n. 7 (luglio 2010): 1404–9. http://dx.doi.org/10.1038/oby.2009.390.
Testo completoMaly Majeed, Anas Hussain. "In-Silico Analysis of Nonsynonymous Single Nucleotide Polymorphism in Human PCSK1 Gene". Bioscience Biotechnology Research Communications 14, n. 1 (25 marzo 2021): 215–19. http://dx.doi.org/10.21786/bbrc/14.1/31.
Testo completoTAYLOR, AUSTIN, YI-CHUN CHEN e BRUCE VERCHERE. "2105-P: Beta Cell PCSK1 Deficiency Increases Diabetes Susceptibility in Male Mice". Diabetes 69, Supplement 1 (giugno 2020): 2105—P. http://dx.doi.org/10.2337/db20-2105-p.
Testo completoShan, Limin, Jiajie Sun, Chunlei Zhang, Xingtang Fang, Chuzhao Lei, Xianyong Lan e Hong Chen. "The polymorphisms of bovine PCSK1 gene and their associations with growth traits". Genes & Genomics 33, n. 1 (febbraio 2011): 57–63. http://dx.doi.org/10.1007/s13258-010-0049-y.
Testo completoMuhsin, Nor I. A., Liz Bentley, Ying Bai, Michelle Goldsworthy e Roger D. Cox. "A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes". Mammalian Genome 31, n. 1-2 (23 gennaio 2020): 17–29. http://dx.doi.org/10.1007/s00335-020-09826-4.
Testo completoKaur, Harleen, Beverly S. Muhlhausler, Pamela Su-Lin Sim, Amanda J. Page, Hui Li, Maria Nunez-Salces, Georgia S. Clarke et al. "Pregnancy, but not dietary octanoic acid supplementation, stimulates the ghrelin-pituitary growth hormone axis in mice". Journal of Endocrinology 245, n. 2 (maggio 2020): 327–42. http://dx.doi.org/10.1530/joe-20-0072.
Testo completoBlanco, Elias H., Bruno Ramos-Molina e Iris Lindberg. "Revisiting PC1/3 Mutants: Dominant-Negative Effect of Endoplasmic Reticulum-Retained Mutants". Endocrinology 156, n. 10 (24 luglio 2015): 3625–37. http://dx.doi.org/10.1210/en.2015-1068.
Testo completoDu, Qingyang, Rui Shao, Wentao Wang, Hui Zhang, Xinmeng Liao, Zhihao Wang, Zhan Yin et al. "Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio)". Nutrients 16, n. 9 (25 aprile 2024): 1271. http://dx.doi.org/10.3390/nu16091271.
Testo completoDuclaux-Loras, Rémi, Patrice Bourgeois, Pierre-Marie Lavrut, Fabienne Charbit-Henrion, Pauline Bonniaud-Blot, Raphael Maudinas, Marie Bournez et al. "A novel mutation of PCSK1 responsible for PC1/3 deficiency in two siblings". Clinics and Research in Hepatology and Gastroenterology 45, n. 6 (novembre 2021): 101640. http://dx.doi.org/10.1016/j.clinre.2021.101640.
Testo completoPyun, Jung-A., Sunshin Kim, Dong Hyun Cha e KyuBum Kwack. "Epistasis between polymorphisms in PCSK1 and DBH is associated with premature ovarian failure". Menopause 21, n. 11 (novembre 2014): 1249–53. http://dx.doi.org/10.1097/gme.0000000000000226.
Testo completoZhang, Hui, Xiaoxiang Hu, Zhipeng Wang, Yuandan Zhang, Shouzhi Wang, Ning Wang, Li Ma et al. "Selection Signature Analysis Implicates the PC1/PCSK1 Region for Chicken Abdominal Fat Content". PLoS ONE 7, n. 7 (11 luglio 2012): e40736. http://dx.doi.org/10.1371/journal.pone.0040736.
Testo completoKummerfeld, Delf-Magnus, Boris V. Skryabin, Juergen Brosius, Sergey Y. Vakhrushev e Timofey S. Rozhdestvensky. "Reference Genes across Nine Brain Areas of Wild Type and Prader-Willi Syndrome Mice: Assessing Differences in Igfbp7, Pcsk1, Nhlh2 and Nlgn3 Expression". International Journal of Molecular Sciences 23, n. 15 (5 agosto 2022): 8729. http://dx.doi.org/10.3390/ijms23158729.
Testo completoGarcía-Martínez, A., D. A. Cano, A. Flores-Martínez, J. Gil, M. Puig-Domingo, S. M. Webb, A. Soto-Moreno e A. Picó. "Why don’t corticotroph tumors always produce Cushing’s disease?" European Journal of Endocrinology 181, n. 3 (settembre 2019): 351–61. http://dx.doi.org/10.1530/eje-19-0338.
Testo completoPanigrahi, Sunil K., Kana Meece e Sharon L. Wardlaw. "Effects of Naltrexone on Energy Balance and Hypothalamic Melanocortin Peptides in Male Mice Fed a High-Fat Diet". Journal of the Endocrine Society 3, n. 3 (28 gennaio 2019): 590–601. http://dx.doi.org/10.1210/js.2018-00379.
Testo completoChou, Chia-Lin, Tzu-Ju Chen, Cheng-Yi Lin, Sung-Wei Lee, Shih-Chang Wang, Shou-Sheng Chu e Ching-Chieh Yang. "PCSK1 Overexpression in Rectal Cancer Correlates with Poor Response to Preoperative Chemoradiotherapy and Prognosis". OncoTargets and Therapy Volume 13 (aprile 2020): 3141–50. http://dx.doi.org/10.2147/ott.s243750.
Testo completoKilpelainen, T. O., S. A. Bingham, K. T. Khaw, N. J. Wareham e R. J. F. Loos. "Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study". Human Molecular Genetics 18, n. 18 (15 giugno 2009): 3496–501. http://dx.doi.org/10.1093/hmg/ddp280.
Testo completoQi, Qibin, Huaixing Li, Ruth J. F. Loos, Chen Liu, Frank B. Hu, Hongyu Wu, Zhijie Yu e Xu Lin. "Association of PCSK1 rs6234 with Obesity and Related Traits in a Chinese Han Population". PLoS ONE 5, n. 5 (17 maggio 2010): e10590. http://dx.doi.org/10.1371/journal.pone.0010590.
Testo completoPhilippe, J., P. Stijnen, D. Meyre, F. De Graeve, D. Thuillier, J. Delplanque, G. Gyapay et al. "A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity". International Journal of Obesity 39, n. 2 (3 giugno 2014): 295–302. http://dx.doi.org/10.1038/ijo.2014.96.
Testo completoCHEN, JIE, MEI YANG, KEHUI ZHAO, AIMIN XU e QINGYANG HUANG. "Polymorphisms in FTO, TMEM18 and PCSK1 are associated with BMI in southern Chinese population". Journal of Genetics 93, n. 2 (agosto 2014): 509–12. http://dx.doi.org/10.1007/s12041-014-0384-x.
Testo completoSeidah, Nabil G., Antonella Pasquato e Ursula Andréo. "How Do Enveloped Viruses Exploit the Secretory Proprotein Convertases to Regulate Infectivity and Spread?" Viruses 13, n. 7 (25 giugno 2021): 1229. http://dx.doi.org/10.3390/v13071229.
Testo completoAhmed, Amna Basheer M., e Badr M. Rasheed Alsaleem. "Enteroendocrine Dysfunction in Two Saudi Sisters". Case Reports in Gastroenterology 15, n. 1 (4 marzo 2021): 290–95. http://dx.doi.org/10.1159/000511761.
Testo completoChoi, Seungbum, Aleksandra Aljakna e Ron Korstanje. "GW28-e0704 PCSK1 MUTANT MICE DISPLAY INCREASED APOA1 LEVEL AND DECREASED PLTP ACTIVITIY IN SERUM". Journal of the American College of Cardiology 70, n. 16 (ottobre 2017): C64—C65. http://dx.doi.org/10.1016/j.jacc.2017.07.220.
Testo completoStijnen, Pieter, Krizia Tuand, Tibor V. Varga, Paul W. Franks, Bert Aertgeerts e John W. M. Creemers. "The Association of Common Variants in PCSK1 With Obesity: A HuGE Review and Meta-Analysis". American Journal of Epidemiology 180, n. 11 (29 ottobre 2014): 1051–65. http://dx.doi.org/10.1093/aje/kwu237.
Testo completoVillalobos-Comparán, Marisela, Hugo Villamil-Ramírez, Teresa Villarreal-Molina, Elena Larrieta-Carrasco, Paola León-Mimila, Sandra Romero-Hidalgo, Leonor Jacobo-Albavera et al. "PCSK1 rs6232 Is Associated with Childhood and Adult Class III Obesity in the Mexican Population". PLoS ONE 7, n. 6 (21 giugno 2012): e39037. http://dx.doi.org/10.1371/journal.pone.0039037.
Testo completoArgente, J., S. Farooqi, E. Van Den Akker, S. Malhotra, P. Kühnen, K. Clément e M. Wabitsch. "Caractéristiques cliniques des porteurs de variants sur les gènes POMC, PCSK1, LEPR, NCOA1 et SH2B1". Annales d'Endocrinologie 84, n. 5 (ottobre 2023): 669. http://dx.doi.org/10.1016/j.ando.2023.07.467.
Testo completoChetty, K., A. Khathi, S. Schneider e Gerda Martha Marx. "Type 2 Diabetes Mellitus Serum Biomarker Levels and Associated Single Nucleotide Polymorphisms in a South African Population". Series of Endocrinology, Diabetes and Metabolism 5, n. 3 (12 ottobre 2023): 100–118. http://dx.doi.org/10.54178/jsedmv5i3001.
Testo completoTAYLOR, AUSTIN, YI-CHUN CHEN, DANIEL PASULA, DAN S. LUCIANI e BRUCE VERCHERE. "123-OR: Deletion of Both Pcsk1 And Pcsk2 in Beta Cells: Lack of Mature Insulin Drives Beta-Cell Expansion and Dysfunction, but Not Severe Diabetes in Mice". Diabetes 70, Supplement 1 (giugno 2021): 123—OR. http://dx.doi.org/10.2337/db21-123-or.
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