Articoli di riviste sul tema "Partially-Separable Structure"

Objective: Previous studies in children with ADHD identified two partially separable familial factors underlying cognitive dysfunction, but evidence in adolescents and adults is lacking. Here, we investigate the etiological structure of cognitive-neurophysiological impairments in ADHD in adolescents and young adults. Method: Factor analyses and multivariate familial models were run in 356 participants from ADHD and control sibling pairs aged 11 to 27 years on data on IQ, digit span forward (DSF) and backward (DSB), and cognitive-performance and event-related potential (ERP) measures from three cognitive tasks. Results: Three familial factors (cF1-3), showing substantial familial overlap with ADHD, captured the familial covariation of ADHD with nine cognitive-ERP measures. cF1 loaded on IQ, mean reaction time (MRT), and reaction-time variability (RTV); cF2 on DSF and DSB; and cF3 on number of errors and ERPs of inhibition and error processing. Conclusion: These results identify three partially separable etiological pathways leading to cognitive-neurophysiological impairments in adolescent and adult ADHD.

A structured version of derivative-free random pattern search optimization algorithms is introduced, which is able to exploit coordinate partially separable structure (typically associated with sparsity) often present in unconstrained and bound-constrained optimization problems. This technique improves performance by orders of magnitude and makes it possible to solve large problems that otherwise are totally intractable by other derivative-free methods. A library of interpolation-based modelling tools is also described, which can be associated with the structured or unstructured versions of the initial pattern search algorithm. The use of the library further enhances performance, especially when associated with structure. The significant gains in performance associated with these two techniques are illustrated using a new freely-available release of the Brute Force Optimizer (BFO) package firstly introduced in [Porcelli and Toint 2017 ], which incorporates them. An interesting conclusion of the numerical results presented is that providing global structural information on a problem can result in significantly less evaluations of the objective function than attempting to building local Taylor-like models.

AbstractOne partially ordered set, Q, is a Tukey quotient of another, P, if there is a map (a Tukey quotient) $\phi :P \to Q$ carrying cofinal sets of P to cofinal sets of Q. Two partial orders which are mutual Tukey quotients of each other are said to be Tukey equivalent. Let ${\cal D}_{\rm{}} $ be the partially ordered set of Tukey equivalence classes of directed sets of size $ \le {\rm{}}$. It is shown that ${\cal D}_{\rm{}} $ contains an antichain of size $2^{\rm{}} $, and so has size $2^{\rm{}} $. The elements of the antichain are of the form ${\cal K}\left( M \right)$, the set of compact subsets of a separable metrizable space M, ordered by inclusion. The order structure of such ${\cal K}\left( M \right)$’s under Tukey quotients is investigated. Relative Tukey quotients are introduced. Applications are given to function spaces and to the complexity of weakly countably determined Banach spaces and Gul’ko compacta.

Background: Some individuals with autism find it challenging to use and understand language in conversation, despite having good abilities in core aspects of language such as grammar and vocabulary. This suggests that pragmatic skills (such as understanding implied meanings in conversation) are separable from core language skills. However, it has been surprisingly difficult to demonstrate this dissociation in the general population. We propose that this may be because prior studies have used tasks in which different aspects of language are confounded. Methods: The present study used novel language tasks and factor analysis to test whether pragmatic language skills are separable from core language skills. 120 adult participants were recruited online to complete a 7-task battery, including a test assessing comprehension of conversational implicature. Results: In confirmatory analysis of a preregistered model, we compared whether the data showed better fit to a two-factor structure (including a pragmatic conversation comprehension and core language factor) or a simpler one-factor structure (comprising a general language factor). The two-factor model showed significantly better fit. Conclusions: This study supports the view that interpreting context-dependent conversational meaning is partially distinct from core language skill. This has implications for understanding the pragmatic language impairments reported in autism.

Background: Some individuals with autism find it challenging to use and understand language in conversation, despite having good abilities in core aspects of language such as grammar and vocabulary. This suggests that pragmatic skills (such as understanding implied meanings in conversation) are separable from core language skills. However, it has been surprisingly difficult to demonstrate this dissociation in the general population. We propose that this may be because prior studies have used tasks in which different aspects of language are confounded. Methods: The present study used novel language tasks and factor analysis to test whether pragmatic understanding of implied meaning, as part of a broader domain involving social understanding, is separable from core language skills. 120 adult participants were recruited online to complete a 7-task battery, including a test assessing comprehension of conversational implicature. Results: In confirmatory analysis of a preregistered model, we compared whether the data showed better fit to a two-factor structure (including a “social understanding” and “core language” factor) or a simpler one-factor structure (comprising a general factor). The two-factor model showed significantly better fit. Conclusions: This study supports the view that interpreting context-dependent conversational meaning is partially distinct from core language skills. This has implications for understanding the pragmatic language impairments reported in autism.

Background: Some individuals with autism find it challenging to use and understand language in conversation, despite having good abilities in core aspects of language such as grammar and vocabulary. This suggests that pragmatic skills (such as understanding implied meanings in conversation) are separable from core language skills. However, it has been surprisingly difficult to demonstrate this dissociation in the general population. We propose that this may be because prior studies have used tasks in which different aspects of language are confounded. Methods: The present study used novel language tasks and factor analysis to test whether pragmatic understanding of implied meaning, as part of a broader domain involving social understanding, is separable from core language skills. 120 adult participants were recruited online to complete a 7-task battery, including a test assessing comprehension of conversational implicature. Results: In confirmatory analysis of a preregistered model, we compared whether the data showed better fit to a two-factor structure (including a “social understanding” and “core language” factor) or a simpler one-factor structure (comprising a general factor). The two-factor model showed significantly better fit. Conclusions: This study supports the view that interpreting context-dependent conversational meaning is partially distinct from core language skills. This has implications for understanding the pragmatic language impairments reported in autism.

Factor analyses suggest that impulsivity traits that capture tendencies to act prematurely or take risks tap partially distinct constructs. We applied genomic structure equation modeling to evaluate the genetic factor structure of two well-established impulsivity questionnaires, using published statistics from genome-wide association studies of up to 22,861 participants. We also tested the hypotheses that delay discounting would be genetically separable from other impulsivity factors and that emotionally triggered facets of impulsivity (urgency) would be those most strongly genetically correlated with an internalizing latent factor. A five-factor model best fitted the impulsivity data. Delay discounting was genetically distinct from these five factors. As expected, the two urgency subscales were most strongly related to an internalizing-psychopathology latent factor. These findings provide empirical genetic evidence that impulsivity can be broken down into distinct categories of differential relevance for internalizing psychopathology. They also demonstrate how measured genetic markers can be used to inform theories of psychology and personality.

At present, ResNet and DenseNet have achieved significant performance gains in the field of finger-vein biometric recognition, which is partially attributed to the dominant design of cross-layer skip connection. In this manner, features from multiple layers can be effectively aggregated to provide sufficient discriminant representation. Nevertheless, an over-dense connection pattern may induce channel expansion of feature maps and excessive memory consumption. To address these issues, we proposed a low memory overhead and fairly lightweight network architecture for finger-vein recognition. The core components of the proposed network are a sequence of sparsified densely connected blocks with symmetric structure. In each block, a novel connection cropping strategy is adopted to balance the channel ratio of input/output feature maps. Beyond this, to facilitate smaller model volume and faster convergence, we substitute the standard convolutional kernels with separable convolutional kernels and introduce a robust loss metric that is defined on the geodesic distance of angular space. Our proposed sparsified densely connected network with separable convolution (hereinafter dubbed ‘SC-SDCN’) has been tested on two benchmark finger-vein datasets, including the Multimedia Lab of Chonbuk National University (MMCBNU)and Finger Vein of Universiti Sains Malaysia (FV-USM), and the advantages of our SC-SDCN can be evident from the experimental results. Specifically, an equal error rate (EER) of 0.01% and an accuracy of 99.98% are obtained on the MMCBNU dataset, and an EER of 0.45% and an accuracy of 99.74% are obtained on the FV-USM dataset.

We classify multipartite entanglement in a unified manner, focusing on a duality between the set of separable states and that of entangled states. Hyperdeterminants, derived from the duality, are natural generalizations of entanglement measures, the concurrence, 3-tangle for 2, 3 qubits respectively. Our approach reveals how inequivalent multipartite entangled classes of pure states constitute a partially ordered structure under local actions, significantly different from a totally ordered one in the bipartite case. Moreover, the generic entangled class of the maximal dimension, given by the nonzero hyperdeterminant, does not include the maximally entangled states in Bell's inequalities in general (e.g., in the \(n \!\geq\! 4\) qubits), contrary to the widely known bipartite or 3-qubit cases. It suggests that not only are they never locally interconvertible with the majority of multipartite entangled states, but they would have no grounds for the canonical \(n\)-partite entangled states. Our classification is also useful for that of mixed states.

An improved GAN-based imaging logging image restoration method is presented in this paper for solving the problem of partially missing micro-resistivity imaging logging images. The method uses FCN as the generative network infrastructure and adds a depth-separable convolutional residual block to learn and retain more effective pixel and semantic information; an Inception module is added to increase the multi-scale perceptual field of the network and reduce the number of parameters in the network; and a multi-scale feature extraction module and a spatial attention residual block are added to combine the channel attention. The multi-scale module adds a multi-scale feature extraction module and a spatial attention residual block, which combine the channel attention mechanism and the residual block to achieve multi-scale feature extraction. The global discriminative network and the local discriminative network are designed to gradually improve the content and semantic structure coherence between the restored parts and the whole image by playing off each other and the generative network. According to the experimental results, the average structural similarity measure of the five sets of imaged logging images with different sizes of missing regions in the test set is 0.903, which is an improvement of about 0.3 compared with other similar methods. It is shown that the method in this thesis can be used for the restoration of micro-resistivity imaging log images with good improvement in semantic structural coherence and texture details, thus providing a new deep learning method to ensure the smooth advancement of the subsequent interpretation of micro-resistivity imaging log images.

Home service robots operating indoors, such as inside houses and offices, require the real-time and accurate identification and location of target objects to perform service tasks efficiently. However, images captured by visual sensors while in motion states usually contain varying degrees of blurriness, presenting a significant challenge for object detection. In particular, daily life scenes contain small objects like fruits and tableware, which are often occluded, further complicating object recognition and positioning. A dynamic and real-time object detection algorithm is proposed for home service robots. This is composed of an image deblurring algorithm and an object detection algorithm. To improve the clarity of motion-blurred images, the DA-Multi-DCGAN algorithm is proposed. It comprises an embedded dynamic adjustment mechanism and a multimodal multiscale fusion structure based on robot motion and surrounding environmental information, enabling the deblurring processing of images that are captured under different motion states. Compared with DeblurGAN, DA-Multi-DCGAN had a 5.07 improvement in Peak Signal-to-Noise Ratio (PSNR) and a 0.022 improvement in Structural Similarity (SSIM). An AT-LI-YOLO method is proposed for small and occluded object detection. Based on depthwise separable convolution, this method highlights key areas and integrates salient features by embedding the attention module in the AT-Resblock to improve the sensitivity and detection precision of small objects and partially occluded objects. It also employs a lightweight network unit Lightblock to reduce the network’s parameters and computational complexity, which improves its computational efficiency. Compared with YOLOv3, the mean average precision (mAP) of AT-LI-YOLO increased by 3.19%, and the detection precision of small objects, such as apples and oranges and partially occluded objects, increased by 19.12% and 29.52%, respectively. Moreover, the model inference efficiency had a 7 ms reduction in processing time. Based on the typical home activities of older people and children, the dataset Grasp-17 was established for the training and testing of the proposed method. Using the TensorRT neural network inference engine of the developed service robot prototype, the proposed dynamic and real-time object detection algorithm required 29 ms, which meets the real-time requirement of smooth vision.

Summary In this paper we present properties of an algorithm to determine the maximum likelihood estimators of the covariance matrix when two processes jointly affect the observations. Additionally, one process is partially modeled by a compound symmetry structure. We perform a simulation study of the properties of an iteratively determined estimator of the covariance matrix.

Abstract How voters use political issues to elect political candidates is of central importance to our understanding of democratic representation. Research on voting behavior often assumes that American voters hold distinct economic and cultural issue preferences. In this research note, we point out that this does not necessarily imply that preferences for candidates’ positions on the two issue dimensions are also additively separable in voters’ decisions. Analyzing survey data on US presidential elections from 1996 to 2016, we estimate to what extent voters’ economic and socio-cultural preferences are nonseparable and find that the two general dimensions act as substitutes in their decisions. Our finding implies that voting decisions are partially structured by an underlying single dimension, as liberal deviations from a voter’s ideal point on social issues can be compensated by conservative deviations on economic issues.

We study the entanglement dynamics of three two-level atoms interacting with a structured reservoir. The atoms are initially prepared in a mixed W state while the reservoir is in the vacuum. We show the dependence of entanglement dynamics on the purity of initial atomic state and on the amount of non-Markovianity. When the initial state of atoms is in a W pure state, the entanglement will decay asymptotically, while it vanishes in a finite time if the initial state is in a mixed W state. In addition, as the memory effect of the environment, entanglement can partially revive after it vanishes, and the revival degree is dependent on the strength of non-Markovian effect. In the end, we consider the entanglement generation and its evolution when the initial state of the atoms system is completely separable.

Procedural learning of spatio-motor and phoneme sequences was investigated in patients with Broca's and Wernick's aphasia and age-matched controls. In Experiment 1, participants performed a standard serial reaction task (SRT) in which they manually responded to a repeating sequence of stimulus locations. Both Broca's and Wernick's aphasics showed intact sequence learning, as indicated by a reliable response time (RT) cost when the repeating sequence was swithched to a random sequence. In Experiment 2, Broca's aphasics and controls performed a new serial search task (SST), which allowed us to investigate the learning of a spatio-motor sequence and a phoneme sequence independently from each other. On each trial, four letters were presented visually, followed by a single auditorily presented letter. Participants had to press one of four response keys to indicate the location of the auditory letter in the visual display. The arrangement of the visual letters was changed from trial to trial such that either the key-presses or the auditory letters followed a repeating pattern, while the other sequence was random. While controls learned both the key-press and the phoneme sequences, Broca's aphasics were selectively impaired in learning the phoneme sequence. This dissociation between learning of spatio-motor and phoneme sequences supports the assumption that partially separable brain systems are involved in proceedural learning of differenct types of sequential structures.

In this paper, we study the static discrete berth allocation problems (BAPs) for large-scale time-critical marine-loading scenarios. The objective is to allocate the vessels to different types of berths so that all the vessels can be loaded within the minimum time under the tidal condition. The BAP is formalized as a min–max problem. This problem is rather complex as the vessels and berths are quite numerous in the large-scale marine-loading problem. We analyze this problem from a novel perspective, and find out that this problem has the characteristic of partially separable. Therefore, the iterative variable grouping genetic algorithm (IVGGA) is designed to search the near-optimal berth allocation plans. The vessels and berths are divided into subgroups, and the genetic algorithm (GA) is applied to generate the near-optimal berth allocation plans in each subgroup. To achieve the balance of loading tasks among subgroups, we propose reallocating some vessels among subgroups according to the berth allocation plans in subgroups. To guarantee the convergency of the algorithm, an iterative vessel reallocation policy is devised considering the loading tasks of different types of berths. We demonstrate the proposed algorithm in dealing with large-scale BAPs through numerical experiments. According to the results, we find that the proposed algorithm would have good performance when the number of vessels in each subgroup are kept in medium scale. Compared with the original GA, our algorithm shows the effectiveness of the iterative variable grouping strategy. The performance of our algorithm is almost not changed as the number of vessels and berths increases. The proposed algorithm could obtain efficient berth allocation plans for the large-scale marine-loading problem.

Abstract Key message The inclusion of multiple traits and multiple environments within a partially separable factor analytic approach for genomic selection provides breeders with an informative framework to utilise genotype by environment by trait interaction for efficient selection. Abstract This paper develops a single-stage genomic selection (GS) approach which incorporates information on multiple traits and multiple environments within a partially separable factor analytic framework. The factor analytic linear mixed model is an effective method for analysing multi-environment trial (MET) datasets, but has not been extended to GS for multiple traits and multiple environments. The advantage of using all information is that breeders can utilise genotype by environment by trait interaction (GETI) to obtain more accurate predictions across correlated traits and environments. The partially separable factor analytic linear mixed model (SFA-LMM) developed in this paper is based on a three-way separable structure, which includes a factor analytic matrix between traits, a factor analytic matrix between environments and a genomic relationship matrix between genotypes. A diagonal matrix is then added to enable a different genotype by environment interaction (GEI) pattern for each trait and a different genotype by trait interaction (GTI) pattern for each environment. The results show that the SFA-LMM provides a better fit than separable approaches and a comparable fit to non-separable and partially separable approaches. The distinguishing feature of the SFA-LMM is that it will include fewer parameters than all other approaches as the number of genotypes, traits and environments increases. Lastly, a selection index is used to demonstrate simultaneous selection for overall performance and stability. This research represents an important continuation in the advancement of plant breeding analyses, particularly with the advent of high-throughput datasets involving a very large number of genotypes, traits and environments.

Abstract Alkaline exonucleases (AE) are present in several large DNA viruses including bacteriophage λ and herpesviruses, where they play roles in viral DNA processing during genome replication. Given the genetic conservation of AEs across viruses infecting different kingdoms of life, these enzymes likely assume central roles in the lifecycles of viruses where they have yet to be well characterized. Here, we applied a structure-guided functional analysis of the bifunctional AE in the oncogenic human gammaherpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV), called SOX. In addition to identifying a preferred DNA substrate preference for SOX, we define key residues important for DNA binding and DNA processing, and how SOX activity on DNA partially overlaps with its functionally separable cleavage of mRNA. By engineering these SOX mutants into KSHV, we reveal roles for its DNase activity in viral gene expression and infectious virion production. Our results provide mechanistic insight into gammaherpesviral AE activity as well as areas of functional conservation between this mammalian virus AE and its distant relative in phage λ.

Among the single-trajectory Gaussian-based methods for solving the time-dependent Schrödinger equation, the variational Gaussian approximation is the most accurate one. In contrast to Heller’s original thawed Gaussian approximation, it is symplectic, conserves energy exactly, and may partially account for tunneling. However, the variational method is also much more expensive. To improve its efficiency, we symmetrically compose the second-order symplectic integrator of Faou and Lubich and obtain geometric integrators that can achieve an arbitrary even order of convergence in the time step. We demonstrate that the high-order integrators can speed up convergence drastically compared to the second-order algorithm and, in contrast to the popular fourth-order Runge–Kutta method, are time-reversible and conserve the norm and the symplectic structure exactly, regardless of the time step. To show that the method is not restricted to low-dimensional systems, we perform most of the analysis on a non-separable twenty-dimensional model of coupled Morse oscillators. We also show that the variational method may capture tunneling and, in general, improves accuracy over the non-variational thawed Gaussian approximation.

Abstract Background Cluster algorithms are gaining in popularity in biomedical research due to their compelling ability to identify discrete subgroups in data, and their increasing accessibility in mainstream software. While guidelines exist for algorithm selection and outcome evaluation, there are no firmly established ways of computing a priori statistical power for cluster analysis. Here, we estimated power and classification accuracy for common analysis pipelines through simulation. We systematically varied subgroup size, number, separation (effect size), and covariance structure. We then subjected generated datasets to dimensionality reduction approaches (none, multi-dimensional scaling, or uniform manifold approximation and projection) and cluster algorithms (k-means, agglomerative hierarchical clustering with Ward or average linkage and Euclidean or cosine distance, HDBSCAN). Finally, we directly compared the statistical power of discrete (k-means), “fuzzy” (c-means), and finite mixture modelling approaches (which include latent class analysis and latent profile analysis). Results We found that clustering outcomes were driven by large effect sizes or the accumulation of many smaller effects across features, and were mostly unaffected by differences in covariance structure. Sufficient statistical power was achieved with relatively small samples (N = 20 per subgroup), provided cluster separation is large (Δ = 4). Finally, we demonstrated that fuzzy clustering can provide a more parsimonious and powerful alternative for identifying separable multivariate normal distributions, particularly those with slightly lower centroid separation (Δ = 3). Conclusions Traditional intuitions about statistical power only partially apply to cluster analysis: increasing the number of participants above a sufficient sample size did not improve power, but effect size was crucial. Notably, for the popular dimensionality reduction and clustering algorithms tested here, power was only satisfactory for relatively large effect sizes (clear separation between subgroups). Fuzzy clustering provided higher power in multivariate normal distributions. Overall, we recommend that researchers (1) only apply cluster analysis when large subgroup separation is expected, (2) aim for sample sizes of N = 20 to N = 30 per expected subgroup, (3) use multi-dimensional scaling to improve cluster separation, and (4) use fuzzy clustering or mixture modelling approaches that are more powerful and more parsimonious with partially overlapping multivariate normal distributions.

AbstractOptimizing the structure of deep neural networks is essential in many applications. Especially in the object detection tasks of Unmanned Aerial Vehicles. Due to the constraints of the onboard platform, a more efficient network is required to meet practical demands. Nevertheless, existing lightweight detection networks exhibit excessive redundant computations and may yield in a certain level of accuracy loss. To address these issues, this paper proposes a new lightweight network structure named Cross-Stage Partially Deformable Network (CSPDNet). The initial proposal consists of a Deformable Separable Convolution Block (DSCBlock), separating feature channels, greatly reducing the computational load of convolution, and applying adaptive sampling to the separated feature map. Subsequently, to establish information interaction between feature layers, a channel weighting module is proposed. This module calculates weights for the separated feature map, facilitating information exchange across channels and resolutions. Moreover, it compensates for the effect of point-wise (1 $$\times$$ × 1) convolutions, filtering out more important feature information. Furthermore, a new CSPDBlock is designed, primarily composed of DSCBlock, establishing multidimensional feature correlations for each separated feature layer. This approach improves the ability to capture critical feature information and reconstruct gradient paths, thereby preserving detection accuracy. The proposed technology achieves a balance between model parameter size and detection accuracy. Furthermore, experimental results on object detection datasets demonstrate that our designed network, using fewer parameters, achieves competitive detection performance results compared to existing lightweight networks YOLOv5n, YOLOv6n, YOLOv8n, NanoDet and PP-PicoDet. The optimization effect of the designed CSPDBlock, using the VisDrone dataset, is validated when incorporated into advanced detection algorithms YOLOv5m, PPYOLOEm, YOLOv7, RTMDetm and YOLOv8m. In more detail, by incorporating the designed modules it was achieved that the parameters were reduced by 10–20% while almost maintaining detection accuracy.

ABSTRACT Herpes simplex virus (HSV) entry into a subset of cells requires endocytosis and endosomal low pH. Preexposure of isolated virions to mildly acidic pH of 5 to 6 partially inactivates HSV infectivity in an irreversible manner. Acid inactivation is a hallmark of viruses that enter via low-pH pathways; this occurs by pretriggering conformational changes essential for fusion. The target and mechanism(s) of low-pH inactivation of HSV are unclear. Here, low-pH-treated HSV-1 was defective in fusion activity and yet retained normal levels of attachment to cell surface heparan sulfate and binding to nectin-1 receptor. Low-pH-triggered conformational changes in gB reported to date are reversible, despite irreversible low-pH inactivation. gB conformational changes and their reversibility were measured by antigenic analysis with a panel of monoclonal antibodies and by detecting changes in oligomeric conformation. Three-hour treatment of HSV-1 virions with pH 5 or multiple sequential treatments at pH 5 followed by neutral pH caused an irreversible >2.5 log infectivity reduction. While changes in several gB antigenic sites were reversible, alteration of the H126 epitope was irreversible. gB oligomeric conformational change remained reversible under all conditions tested. Altogether, our results reveal that oligomeric alterations and fusion domain changes represent distinct conformational changes in gB, and the latter correlates with irreversible low-pH inactivation of HSV. We propose that conformational change in the gB fusion domain is important for activation of membrane fusion during viral entry and that in the absence of a host target membrane, this change results in irreversible inactivation of virions. IMPORTANCE HSV-1 is an important pathogen with a high seroprevalence throughout the human population. HSV infects cells via multiple pathways, including a low-pH route into epithelial cells, the primary portal into the host. HSV is inactivated by low-pH preexposure, and gB, a class III fusion protein, undergoes reversible conformational changes in response to low-pH exposure. Here, we show that low-pH inactivation of HSV is irreversible and due to a defect in virion fusion activity. We identified an irreversible change in the fusion domain of gB following multiple sequential low-pH exposures or following prolonged low-pH treatment. This change appears to be separable from the alteration in gB quaternary structure. Together, the results are consistent with a model by which low pH can have an activating or inactivating effect on HSV depending on the presence of a target membrane.

AbstractThis paper presents a novel partially distributed outer approximation algorithm, named PaDOA, for solving a class of structured mixed integer convex programming problems to global optimality. The proposed scheme uses an iterative outer approximation method for coupled mixed integer optimization problems with separable convex objective functions, affine coupling constraints, and compact domain. PaDOA proceeds by alternating between solving large-scale structured mixed-integer linear programming problems and partially decoupled mixed-integer nonlinear programming subproblems that comprise much fewer integer variables. We establish conditions under which PaDOA converges to global minimizers after a finite number of iterations and verify these properties with an application to thermostatically controlled loads and to mixed-integer regression.

Abstract Structured light plays an essential role in several quantum information protocols by using the degrees of freedom of light to encode qubits. For exploring different correlations, especially in mixed states, such as discord, it is necessary to prepare partially entangled states. In this work, we present a theoretical and experimental study of a partial nonseprable spin-orbit modes. By exploring classical-quantum analogy, we perform the measurement of the Concurrence of partially separable modes directly from projective measurment of polarization. The results show a clear agreement with predictions of quantum theory for partially entangled states. We also perform a study of CHSH inequality and show that partial violation is observed in entire agreement with the expected by Quantum Theory. For the maximally nonseparable mode, we achieve a violation of $S=2.73 \pm 0.03 $, one of the higher ones observed for spin-orbit modes based on our best knowledge.

Emerging autonomous vehicles (AVs) are expected to bring about a revolution in both the automotive industry and transportation systems. Introducing AVs into the existing mobility system with human-driven vehicles (HVs) yields mixed traffic with the following new features: in-vehicle compensation on value of time for AV users, distinct road capacities for pure AV and HV flows, and stochastic road capacity for the inseparable AV-HV traffic pattern. In this paper, we aim to investigate equilibrium traffic dynamics for the morning commuting problem where AVs and HVs coexist in a transportation corridor by considering these new features, and also explore several novel mixed AV-HV traffic management strategies. The AV-HV traffic pattern could be either separable (i.e., pure AV flow and pure HV flow depart from home in different periods) or inseparable, depending on the user profile condition. In addition to deriving departure time equilibriums for scenarios with separable traffic flows, significant effort is put into the scenario with an inseparable AV-HV traffic pattern, where stochastic road capacity is taken into account. Based on these equilibrium traffic analyses, we propose and explore some new traffic management strategies, including AV certificate of entitlement management scheme for scenarios with separable traffic flows and departure-period management (DPM) scheme and lane management policies for the scenario with an inseparable AV-HV traffic pattern. Eligibilities for applying these strategies are analytically derived and extensively discussed, and numerical experiments are conducted to demonstrate our theoretical findings and reveal the underlying impacts of road capacity randomness. Some lessons learned from the numerical experiments are (i) overlooking the impact of road capacity uncertainty will lead to an overestimation of system performance and even yield biased policymaking, (ii) the full dedicated-lane policy is the preferred option for the medium-level AV situation and partial dedicated-lane policies are more attractive choices for the early AV era or a market with a high AV share, and (iii) the DPM scheme could be a better substitute for partially dedicated-lane policies. Funding: This study was supported by the Ministry of Education of Singapore [Project T2EP40222-0002 under the MOE Tier 2 Grant] and the National Natural Science Foundation Council of China [Grant 72001133 and the Excellent Young Scientists Fund Program (Overseas)]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2021.0469 .

This essay sheds lights on the framing process during the research on the crossing between natural and artificial systems. To approach this, we must outline the machine-natural system relation. From this notion, technology is not seen as an external thing, nor even in contrast to an imaginary of nature, but as an effect that emerges from our thinking and revealing being that, in many cases, may be reduced to an issue of knowledge and action. Here, we want to consider the concept of transduction from Gilbert Simondon as one possible framework for considering the socio-technological actions at stake. His thought offers a detailed conceptual vocabulary for the question of individuation as a “revelation process”, a concern with how things come into existence and proceed temporally as projective entities.Moreover, our approach to the work of philosopher Simondon marked the starting point of our interest and approach to the issue of technique and its politics. From this perspective, the reflection given by Simondon in his thesis on the Individuation and the Mode of Existence of Technical Objects, is to trace certain reasons that are necessary for the development of this project and helping to explain it. In first place, Simondon does not state a specific regime of “human individuation”. The possibility of a psychic and collective individuation is produced, as is manifested when addressing the structure of his main thesis, at the heart of biological individuation; Simondon strongly attacks the anthropocentric tendencies that attempt to establish a defining boundary between biological and psychic reality. We may presume, then, that the issue of language as a defining and differencing element of the human does not interest him; it is at this point that our project begins to focus on employing the transduction of the téchnē as a metaphor of life (Espinoza Lolas et al.); regarding the limits that language may imply for the conformation and expression of the psychic reality. In second place, this critique to the economy of attention present across our research and in Simondon’s thinking seeks to introduce a hypothesis raised in another direction: towards the issue of the technique. During the introduction of his Mode of Existence of Technical Objects, Simondon shows some urgency in the need to approach the reality of technical objects as an autonomous reality and as a configuring reality of the psychic and collective individualisation. Facing the general importance granted to language as a key element of the historical and hermeneutical, even ontological, aspects of the human being, Simondon considers that the technique is the reality that plays the fundamental role of mediating between the human being and the world.Following these observations, a possible question that will guide our research arises: How do the technologisation and informatisation of the cultural techniques alter the nature itself of the knowing of the affection of being with others (people, things, animals)? In the hypothesis of this investigation we claim that—insofar as we deliver an approach and perspective on the technologisation of the world as a process of individuation (considering Simondon’s concept in this becoming, in which an artificial agent and its medium may get out of phase to solve its tensions and give rise to physical or living individuals that constitute their system and go through a series of metastable equilibria)—it’s possible to prove this capacity of invention as a clear example of a form of transindividual individuation (referring to the human being), that thanks to the information that the artificial agent acquires and recovers by means of its “imagination”, which integrates in its perception and affectivity, enables the creation of new norms or artifacts installing in its becoming, as is the case of bioeconomy and cognitive capitalism (Fumagalli 219). It is imperious to observe and analyse the fact that the concept of nature must be integrated along with the concept of Cosmotecnia (Hui 3) to avoid the opposition between nature and technique in conceptual terms, and that is the reason why in the following section we will mention a third memory that is inscribed in this concept. There is no linear time development in human history from nature to technique, from nature to politics.The Extended MindThe idea of memory as something transmissible is important when thinking of the present, there is no humanity outside the technical, neither prior to the technical, and it is important to safeguard this idea to highlight the phýsis/téchnē dichotomy presented by Simondon and Stigler. It is erroneous to think that some entity may exceed the human, that it has any exteriority when it is the materialization of the human forms, or even more, that the human is crossed by it and is not separable. For French philosopher Bernard Stiegler there is no human nature without technique, and vice versa (Stigler 223). Here appears the issue of knowing which are the limits where “the body of the human me might stop” (Hutinel 44), a first glimpse of externalized memory was the flint axe, which is made by using other tools, even when its use is unknown. Its mere existence preserves a knowledge that goes beyond who made it, or its genetic or epigenetic transmission is preserved beyond the organic.We raise the question about a phýsis coming from the téchnē, it is a central topic that dominates the discussion nowadays, about technology and its ability to have a transforming effect over every area of contemporary life and human beings themselves. It is being “revealed” that the true qualitative novelty of the technological improves that happen in front of our eyes resides not only in the appearance of new practices that are related to any particular scientific research. We must point out the evident tension between bíos and zôê during the process of this adaptation, which is an ontological one, but we also witness how the recursivity becomes a modus operandi during this process, which is both social and technological. Just as the philosophy of nature, the philosophy of biology confronts its own limit under the light shed by the recursive algorithms implemented as a dominant way of adaptation, which is what Deleuze called societies of control (Deleuze 165). At the same time, there is an artificial selection (instead of a natural selection) imposed by the politics of transhumanism (for example, human improvement, genetic engineering).In this direction, a first aspect to consider resides in that life, held as an object of power and politics, does not constitute a “natural life”, but the result of a technical production from which its “nature” develops, as well as the possibilities of its deployment. Now then, it is precisely due to this gesture that Stiegler longs to distinguish between what is originary in mankind and its artefactual or artificial becoming: “the prosthesis is not a simple extension of the human body, it is the constitution of said body insofar as ‘human’ (the quotes belong to the constitution). It is not a ‘medium’ for mankind, but its end, and it is known the essential mistakenness of the expression, ‘the end of mankind’” (Stiegler 9). Before such phenomena, it is appropriate to lay out a reflexive methodology centered in observing and analysing the aforementioned idea by Stiegler that there is no mankind without techniques; and there is no technique without mankind (Stigler 223). This implies that this idea of téchnē comprises both the techniques needed to create things, as the technical products resulting from these techniques. The word “techniques” also becomes ambiguous among the modern technology of machines and the primitive “tools” and their techniques, whether they have become art of craft, things that we would not necessarily think as “technology”. What Stiegler is suggesting here is to describe the scope of the term téchnē within an ontogenetic and phylogenetic process of the human being; providing us a reflection about what do we “possess as a fundamental thing” for our being as humans is also fundamental to how “we experience time” since the externalization of our memory into our tools, which Stiegler understands as a “third kind” of memory which is separated from the internal memory that is individually acquired from our brain (epigenetic), and the biological evolutive memory that is inherited from our ancestors (phylogenetic); Stiegler calls this kind of evolutive process epiphylogenetic or epiphylogenesis. Therefore, we could argue that we are defined by this process of epiphylogenesis, and that we are constituted by a past that we ourselves, as individuals, have not lived; this past is delivered to us through culture, which is the fusion of the “technical objects that embody the knowledge of our ancestors, tools that we adopt to transform our surroundings” (Stiegler 177). These supports of external memory (this is, exteriorisations of the consciousness) provide a new collectivisation of the consciousness that exists beyond the individual.The current trend of investigation of ontogeny and phylogeny is driven by the growing consensus both in sciences and humanities in that the living world in every one of its aspects – biologic, semiotic, economic, affective, social, etc. – escapes the finite scheme of description and representation. It is for this reason that authors such as Matteo Pasquinelli refer, in a more modest way, to the idea of “augmented intelligence” (9), reminding us that there is a posthuman legacy between human and machine that still is problematic, “though the machines manifest different degrees of autonomous agency” (Pasquinelli 11).For Simondon, and this is his revolutionary contribution to philosophy, one should think individuation not from the perspective of the individual, but from the point of view of the process that originated it. In other words, individuation must be thought in terms of a process that not only takes for granted the individual but understands it as a result.In Simondon’s words:If, on the contrary, one supposes that individuation does not only produce the individual, one would not attempt to pass quickly through the stage of individuation in order arrive at the final reality that is the individual--one would attempt to grasp the ontogenesis in the entire progression of its reality, and to know the individual through the individuation, rather than the individuation through the individual. (5)Therefore, the epistemological problem does not fall in how the téchnē flees the human domain in its course to become technologies, but in how these “exteriorization” processes (Stiegler 213) alter the concepts themselves of number, image, comparison, space, time, or city, to give a few examples. However, the anthropological category of “exteriorization” does not bring entirely justice to these processes, as they work in a retroactive and recursive manner in the original techniques. Along with the concept of text and book, the practice of reading has also changed during the course of digitalisation and algorithmisation of the processing of knowledge; alongside with the concept of comparison, the practice of comparison has changed since the comparison (i.e. of images) has become an operation that is based in the extraction of data and automatic learning. On the other side, in reverse, we must consider, in an archeological and mediatic fashion, the technological state of life as a starting point from which we must ask what cultural techniques were employed in first place. Asking: How does the informatisation of the cultural techniques produce new forms of subjectivity? How does the concept of cultural techniques already imply the idea of “chains of operations” and, therefore, a permanent (retro)coupling between the living and the non-living agency?This reveals that classical cultural techniques such as indexation or labelling, for example, have acquired ontological powers in the Google era: only what is labelled exists; only what can be searched is absolute. At the same time, in the fantasies of the mediatic corporations, the variety of objects that can be labelled (including people) tends to be coextensive with the world of the phenomena itself (if not the real world), which will then always be only an augmented version of itself.Technology became important for contemporary knowledge only through mediation; therefore, the use of tools could not be the consequence of an extremely well-developed brain. On the contrary, the development of increasingly sophisticated tools took place at the same pace as the development of the brain, as Leroi-Gourhan attempts to probe when studying the history of tools together with the history of the human skeleton and brain. And what he managed to demonstrate is that the history of technique and the history of the human being run in parallel lines; they are, if not equal, at least inextricable. Even today, the progress of knowledge is still not completely subordinated to the technological inversion (Lyotard 37). In short, human evolution is inseparable from the evolution of the téchne, the evolution of technology. One may simply think the human being as a natural animal, isolated from the external material world. What he becomes and what he is, is essentially bonded to the techniques, from the very beginning. Leroi-Gourhan puts it this way in his text Gesture and Speech: “the apparition of tools as a species ... feature that marks the boundary between animals and humans” (90).To understand the behavior of the technological systems is essential for our ability to control their actions, to harvest their benefits and to minimize their damage. Here it is argued that this requires a wide agenda of scientific investigation to study the behavior of the machine that incorporates and broadens the biotechnological discipline, and includes knowledges coming from all sciences. In some way, Simondon sensed this encounter of knowledges, and proposed the concept of the Allagmatic, or theory of operations, “constituted by a systematized set of particular knowledges” (Simondon 469). We could attempt to begin by describing a set of questions that are fundamental for this emerging field, and then exploring the technical, legal, and institutional limitations in the study of technological agency.Information, Communication and SignificationTo establish the relation between information and communication, we will speak from the following two perspectives: first with Norbert Wiener, then with Simondon. We will see how the concept of information is essential to start understanding communication in an artificial agent.On one side, we have the notion from Wiener about information that is demarcated in his project about cybernetics. Cybernetics is the study of communication and control through the inquiry of messages in animals, human beings, and machines. This idea of information arises from the interrelation with the surrounding. Wiener defines it as the “content of what is an interchange object with the external world, while we adjust to it and make it adjust to us” (Wiener 17-18). In other words, we receive and use information since we interact with the world in which we live. It is in this sense that information is connected to the idea of feedback that is defined as the exchange and interaction of information in our systems or other systems. In Wiener’s own words, feedback is “the property of adjusting the future behavior to facts of the past” (31).Information, for Wiener, is influenced, at the same time, by the mathematic and probabilistic idea from the theory of information. Wiener refers to the amount of information that finds its starting point at the mechanics of statistics, along with the concept of entropy, inasmuch that the information is opposed to it. Therefore, information, by supplying a set of messages, indicates a measure of organisation. Argentinian philosopher Pablo Rodríguez adds that “information [for Wiener] is a new physical category of the universe. [It is] the measure of organization of any entity, an organization without which the material and energetic systems wouldn’t be able to survive” (2-3). This way, we have that information responds to the measure of organization and self-regulation of a given system.Moreover, and almost in complete contrast, we have the concept given by Simondon, where information is applicable to the whole possible range: animals, machines, human beings, molecules, crystals, etc. In this sense, it is more versatile, as it exceeds the domains of the technique. To understand well the scope of this concept we will approach it from two definitions. In first place, Simondon, in his conference Amplification in the Process of Information, in the book Communication and Information, claims that information “is not a thing, but the operation of a thing that arrives to a system and produces a transformation in there. The information can’t be defined beyond this act of transformative incidence, and the operation of receiving” (Simondon 139). From this definition it follows the idea of modulation, just when he refers to the “transformation” and “act of transformative incidence” modulation corresponds to the energy that flows amplified during that transformation that occurs within a system.There is a second definition of information that Simondon provides in his thesis Individuation in Light of Notions of Form and Information, in which he claims that: “the information signal is not just what is to be transmitted … it is also that what must be received, this is, what must adopt a signification” (Simondon 281). In this definition Simondon clearly distances himself from Wiener’s cybernetics, insofar as it deals with information as that which must be received, and not that that is to be transmitted. Although Simondon refers to a link between information and signification, this last aspect is not measured in linguistic terms. It rather expresses the decodification of a given code. This is, signification, and information as well, are the result of a disparity of energies, namely, between the overlaying of two possible states (0 and 1, or on and off).This is a central point of divergence with Wiener, as he refers to information in terms of transference of messages, while Simondon does it in terms of transformation of energies. This way, Simondon adds an energy element to the traditional definition of information, which now works as an operation, based in the transformation of energies as a result of a disparity or the overlaying of two possible elements within a system (recipient). It is according to this innovative element that modulation operates in a metastable system. And this is precisely the last concept we need to clarify: the idea of metastability and its relationship with the recipient-system.Metastability is an expression that finds its origins in thermodynamics. Philosophy traditionally operates around the idea of the stability of the being, while Simondon’s proposal states that the being is its becoming. This way, metastability is the condition of possibility of the individuation insofar as the metastable medium leaves behind a remainder of energy for future individuation processes. Thus, metastability refers to the temporal equilibrium of a system that remains in time, as it maintains within itself potential energy, useful for other future individuations.Returning to the conference Amplification in the Process of Information, Simondon points out that “the recipient metastability is the condition of efficiency of the incident information” (139). In such sense, we may claim that there is no information if the signal is not received. Therefore, the recipient is a necessary condition for said information to be given. Simondon understands the recipient as a mixed system (a quasi-system): on one hand, it must be isolated in terms of energy, and it must count with a membrane that allows it to not spend all the energy at the same time; on the other hand, it must be heteronomous, as it depends on an external input of information to activate the system (recipient).The metastable medium is the one indicated to understand the artificial agent, as it leaves the possibility open for the potential energy to manifest and not be spent all at once, but to leave a remainder useful for future modulations, and so, new transformations may occur. At the same time, Simondon’s concept of information is the most convenient when referring to communication and the relationship with the medium, primarily for its property of modulating potential energy. Nevertheless, it is also necessary to retrieve the idea of feedback from Wiener, as it is in the relationship of the artificial agent with its surrounding (and the world) that information is given, and it may flow amplified through its system. By this, significations manage to decode the internal code of the artificial agent, which represents the first gesture towards the opening of the communication.ConclusionThe hypotheses on extended cognition are subject to a huge amount of debate in the artistic, philosophical, and science of cognition circles nowadays, but their implications extend further beyond metaphysics and sciences of the mind. It is apparent that we have just began to scratch the surface of the social sphere in a broader way; realising that these start from cultural branches of the sight; as our minds are; if our minds are partially poured into our smartphones and even in our homes, then it is not a transformation in the human nature, but the latest manifestation of an ancient human ontology of the organic cognitive and informative systems dynamically assembled.It is to this condition that the critical digital humanities and every form of critique should answer. This is due to an attempt to dig out the delays and ruptures within the systems of mass media, by adding the relentless belief in real time as the future, to remind that systems always involve an encounter with a radical “strangeness” or “alienity”, an incommensurability between the future and the desire that turns into the radical potential of many of our contemporary social movements and politics. Our challenge in our critical job is to dismantle the practice of the representation and to reincorporate it to different forms of space and experience that are not reactionary but imaginary. What we attempt to bring into the light here is the need to get every spectator to notice the limits of the machinic vision and to acknowledge the role of image in the recruitment of liminal energies for the capital. The final objective of this essay will be to see that nature possesses the technique of an artist who renders contingency into necessity and inscribes the infinite within the finite, in arts it is not the figure of nature that corresponds to individuation but rather the artist whose task is not only to render contingency necessary as its operation, but also aim for an elevation of the audience as a form of revelation. The artist is he who opens up, through his or her work, a process of transindividuation, meaning a psychical and collective individuation.ReferencesDeleuze, Gilles. “Post-Script on Control Societies.” Polis 13 (2006): 1-7. 14 Feb. 2020 <http://journals.openedition.org/polis/5509>.Espinoza Lolas, Ricardo, et al. “On Technology and Life: Fundamental Concepts of Georges Caguilhem and Xavier Zubiri’s Thought.” Ideas y Valores 67.167 (2018): 127-47. 14 Feb. 2020 <http://dx.doi.org/10.15446/ideasyvalores.v67n167.59430>.Fumagalli, Andrea. Bioeconomía y Capitalismo Cognitivo: Hacia un Nuevo Paradigma de Acumulación. Madrid: Traficantes de Sueños, 2010.Hui, Yuk. “On Cosmotechnics: For a Renewed Relation between Technology and Nature in the Anthropocene.” Techné: Research in Philosophy and Technology 21.2/3 (2017): 319-41. 14 Feb. 2020 <https://www.pdcnet.org/techne/content/techne_2017_0021_42769_0319_0341>.Leroi-Gourhan, André. El Gesto y la Palabra. Venezuela: Universidad Central de Venezuela, 1971.———. El Hombre y la Materia: Evolución y Técnica I. Madrid: Taurus, 1989.———. El Medio y la Técnica: Evolución y Técnica II. Madrid: Taurus, 1989.Lyotard, Jean-François. La Condición Postmoderna: Informe sobre el Saber. Madrid: Cátedra, 2006.Pasquinelli, Matteo. “The Spike: On the Growth and Form of Pattern Police.” Nervous Systems 18.5 (2016): 213-20. 14 Feb. 2020 <http://matteopasquinelli.com/spike-pattern-police/>. Rivera Hutinel, Marcela.“Techno-Genesis and Anthropo-Genesis in the Work of Bernard Stiegler: Or How the Hand Invents the Human.” Liminales, Escritos Sobre Psicología y Sociedad 2.3 (2013): 43-58. 15 Dec. 2019 <http://revistafacso.ucentral.cl/index.php/liminales/article/view/228>.Rodríguez, Pablo. “El Signo de la ‘Sociedad de la Información’ de Cómo la Cibernética y el Estructuralismo Reinventaron la Comunicación.” Question 1.28 (2010): 1-17. 14 Feb. 2020 <https://perio.unlp.edu.ar/ojs/index.php/question/article/view/1064>.Simondon, Gilbert. Comunicación e Información. Buenos Aires: Editorial Cactus, 2015.———. La Individuación: a la luz de las nociones de forma y de información. Buenos Aires: La Cebra/Cactus, 2009 / 2015.———. El Modo de Existencia de los Objetos Técnicos. Buenos Aires: Prometeo, 2007.———. “The Position of the Problem of Ontogenesis.” Parrhesia 7 (2009): 4-16. 4 Nov. 2019 <http://parrhesiajournal.org/parrhesia07/parrhesia07_simondon1.pdf>.Stiegler, Bernard. La Técnica y el Tiempo I. Guipúzcoa: Argitaletxe Hiru, 2002.———. “Temporality and Technical, Psychic and Collective Individuation in the Work of Simondon.” Revista Trilogía Ciencia Tecnología Sociedad 4.6 (2012): 133-46.Wiener, Norbert. Cibernética y Sociedad. Buenos Aires: Editorial Sudamericana, 1958.