Tesi sul tema "Pallandt"
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Powroźnik, Paulina. "Sensing mechanism in semiconducting hybrid structures for DMMP detection". Doctoral thesis, Katowice : Uniwersytet Śląski, 2020. http://hdl.handle.net/20.500.12128/15206.
Testo completoWagschal, Simon. "Synthèse d'hétérocycles et réactions pallado-catalysées". Phd thesis, Ecole Polytechnique X, 2010. http://pastel.archives-ouvertes.fr/pastel-00637723.
Testo completoAuffrant, Audrey. "Complexes tricarbonylmanganèse : premières fonctionnalisations par réactions pallado-catalysées". Paris 6, 2002. http://www.theses.fr/2002PA066017.
Testo completoPhanumartwiwath, Anuchit. "Novel halogenation and pallado-biology strategies for biological probes". Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:65892f29-353e-471a-9dfa-b3fc7e2f806d.
Testo completoIgnasiak, Hanna. "Synteza pochodnych pirydyny w reakcjach sprzęgania katalizowanych kompleksami palladu". Doctoral thesis, Katowice : Uniwersytet Śląski, 2010. http://hdl.handle.net/20.500.12128/5166.
Testo completoVezzosi, Ginevra. "Gli epigrammi gnomici e filosofici di Pallada di Alessandria". Doctoral thesis, Universita degli studi di Salerno, 2015. http://hdl.handle.net/10556/1914.
Testo completoQuesta tesi, dedicata all’opera di Pallada di Alessandria (IV sec. d.C.) priva a tutt’oggi sia di edizione critica che di commento filologico-letterario, è divisa in due parti: una parte generale dedicata alla discussione di alcuni aspetti della produzione del poeta e un commento filologicoletterario parola per parola di una sezione del corpus epigrammatico, gli epigrammi gnomicofilosofici. La prima parte consta di sei capitoli. Nel primo si affronta il grosso problema della cronologia palladiana, i capitoli II, III, IV sono interamente dedicati ad una trattazione dettagliata rispettivamente della poetica, filosofia e religione di Pallada, nel capitolo V viene fornita una descrizione delle principali caratteristiche metriche e prosodiche del gruppo degli epigrammi gnomici e filosofici, il capitolo VI infine offre una rapida disamina dei manoscritti che ci hanno tramandato il testo palladiano. Nella seconda parte, che consiste nel commento parola per parola, per ogni epigramma, oltre al testo greco, è stata fornita la traduzione italiana. Come testo base è stata utilizzata l’edizione di L. A. Guichard (c.d.s.). [a cura dell'autore]
XII n.s.
Countryman, James R. "Agricultural terracing and landscape history at Monte Pallano, Abruzzo, Italy". Oberlin College Honors Theses / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=oberlin1337974268.
Testo completoHorhant, David. "Borylation pallado-catalysée et couplages de Suzuki-Miyaura boro-sélectifs". Rennes 1, 2005. http://www.theses.fr/2005REN1S079.
Testo completoLee, Kevin Stuart. "City-dwelling Samnites : urban settlement at Monte Pallano and Monte Vairano". Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58790.
Testo completoArts, Faculty of
Classical, Near Eastern and Religious Studies, Department of
Graduate
Ouchaou, Kahina. "Catalyseurs hétérogènes à base de polysaccharides pour des réactions pallado-catalysées". Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112221.
Testo completoThis work describes the preparation, screening and use of heterogeneous catalysts based on polysaccharides. The main goal of our project was to evaluate two polysaccharides: alginates and chitosan as renewable supports for heterogeneous catalysis.Alginates are known to form gels with most di- and multivalent cations due to the presence of the carboxylate functions of their matrix. And chitosan is an attractive polysaccharide for application in catalysis owing to the presence of readily functionalizable amino group and its insolubility in organic solvents.First, our work focused on evaluating the catalytic activity of bimetallic Mn+-Pd catalysts supported on alginate in C—C coupling reactions. Among them, one system demonstrated remarkable catalytic properties for the Suzuki-Miyaura coupling. Then, the oxidation of alcohols catalyzed by Alginate-Mn+-Pd2+ catalyst was investigated. Two catalysts demonstrated good activity for oxidation of benzylic and allylic alcohol.In a second time, we developed new NHC ligands in order to anchor them on chitosan: two new NHC ligands for olefin metathesis and several NHC pincer CNC ligands for C—C coupling reactions in water. A palladium complex obtained with one our new ligand bearing long alkyl chains showed good activity in the Suzuki-Miyaura coupling in pure water.Finally, a new palladium (II) catalyzed decarboxylative cyanation reaction was investigated. This methodology is the first example of direct conversion of aryl carboxylic acid into the corresponding aryl nitrile. This reaction is well adapted to labeled compound synthesis
Roche, Maxime. "Couplages pallado-catalysés de N-tosylhydrazones : synthèse d’oléfines apparentées à l’isocombrétastatine A4". Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114843.
Testo completoThis thesis work concerns the development of new palladium catalyzed cross-coupling reactions of N-tosylhydrazones and their applications to the synthesis of isocombretastatin A4 (isoCA-4) analogs. The first part of this work is dedicated to the study of the reactivity of hindered N-tosylhydrazones in coupling with aryl halides. A protocol has been developed to synthesize ortho/ortho’-disubstituted 1,1-diarylethylenes related to isoCA-4. Another part of this thesis is dedicated to the development of tandem reactions involving N-tosylhydrazones. Two new reactions are reported, a Barluenga cross coupling-Buchwald-Hartwig cross coupling tandem reaction as well as a Barluenga cross coupling-Suzuki-Miyaura cross coupling tandem reaction. In the last chapter, oxidative coupling of indoles with N-tosylhydrazones was examined. N-vinylindoles synthesized by this way showed promising antiproliferative activities
Song, Tao. "Alkylation allylique asymétrique pallado-catalysée : contrôle de centres quaternaires au sein d'hétérocycles azotés". Thesis, Paris Sciences et Lettres (ComUE), 2018. http://www.theses.fr/2018PSLET012.
Testo completoThe development of new synthetic tools allowing to create quaternary stereogenic centers remains an important challenge in synthetic organic chemistry. In this context, the palladium-catalyzed asymmetric allylic alkylation has become a particularly effective tool. The first chapter of this thesis is focused on the application of this key reaction to succinimide type compounds. This convergent method has allowed us to access a number of succinimide derivatives bearing a quaternary stereogenic center in high yields and excellent enantioselectivities. Moreover, in order to demonstrate the synthetic utility of the method, the resulting alpha-quaternary succinimides were converted to various useful building block including pyrrolidines and spirocyclic frameworks. The second chapter is focused on the application of the palladium-catalyzed asymmetric allylic alkylation to alpha,gamma-disubstituted 2-siloxypyrroles in order to access gamma-lactams bearing an alpha-quaternary stereogenic center in high yields and enantioselectivities. The latter were eventually converted to the corresponding pyrrolidines and pipéridinesKeywords: asymmetric catalysis, allylic alkylation, palladium, succinimides, lactams, all-carbon quaternary stereogenic centers
Wahl, Benoit. "Nouvelle réaction domino pallado-catalysée : alcoxycarbonylation / allylation pour la synthèse d’esters alpha-allylés". Thesis, Lille 1, 2011. http://www.theses.fr/2011LIL10084/document.
Testo completoThe aim of this work was to develop a new domino reaction combining two different pallado-catalysed transformations: alcoxycarbonylation and allylic alkylation for the synthesis of α-allylated esters.First of all, each elementary reaction involved in the domino reaction was studied individually. When benzyl halide was used as the starting material, the incompatibility of the reactions conditions was clearly demonstrated, whereas the use of [Alpha]-chloroketones, leading to intermediate β-ketoesters, more reactive in allylic alkylation showed us the feasibility of this kind of transformation. Alcoxycarbonylation of α-chloroketones was optimized and the use of Xantphos as an ancillary ligand allowed us to get β-ketoesters with very good yields.Then, [Alpha]-chloroketones alcoxycarbonylation and subsequent allylation could be efficiently combined to provide a new pseudo-domino type I sequence wherein the same catalytic system drives the two concatenated cycles at moderate catalyst loadings. The use of allylic phenyl ether, less reactive to the metal than other allylic substrates, turned out to be the key factor, along with the use of Xantphos, to get allylated ketoesters with good yields and selectivity.This new domino reaction has been extended to several substrates which precludes interesting perspectives for the synthesis of highly functionalized cyclic structures via its intramolecular version
Begouin, Agathe. "Réalisation de couplages pallado-catalysés en série thiophénique : synthèse de composés biologiquement actifs". Thesis, Metz, 2007. http://www.theses.fr/2007METZ020S/document.
Testo completoN-Arylation of primary and secondary amines by Buchwald-Hartwig C-N cross-coupling reactions is a very convenient pathway for the synthesis of arylamines. Up to now, only few examples of arylamines synthesis were described in the thiophene series, although arylaminothiophenes generally show very interesting biological and electronic properties. Thus, we investigated the reactivity of 2- and 3- bromothiophene derivatives in palladium-catalyzed cross-coupling. Then we also studied the reactivity of aminothiophenes in those same cross-coupling reactions. Using this way, the expected diarylamines were successfully synthesized. An easy access to thienopyrimidinone derivatives was also described via a one-pot C-N coupling and intramolecular cyclization
Begouin, Agathe Anne Bérenice Kirsch Gilbert. "Réalisation de couplages pallado-catalysés en série thiophénique. Synthèse de composés biologiquement actifs". [S.l.] : [s.n.], 2007. ftp://ftp.scd.univ-metz.fr/pub/Theses/2007/Begouin.Agathe.SMZ0720.pdf.
Testo completoPican, Stéphanie. "Etude de la réaction de couplage C-P pallado-catalysée : versions racémique et énantiosélective". Caen, 2004. http://www.theses.fr/2004CAEN2037.
Testo completoVasseur, Alexandre. "Fonctionnalisation C-H d’hétérocycles dérivés de la biomasse : réactions pallado-catalysées de Heck déshydrogénantes". Thesis, Reims, 2012. http://www.theses.fr/2012REIMS017/document.
Testo completoThis thesis describes Pd-catalyzed dehydrogenative Heck reactions of heteroarenes that could be derived from the biomass with electron-rich alkenes such as styrenes. The first chapter presents a new methodology enabling cross coupling dehydrogenative Heck Reactions of furans and thiophenes with styrenes under Mild conditions and discusses the Influence of the oxidizing agent on the reaction rate. The second chapter focuses on ESI-MS studies of the dehydrogenative Heck reactions of furans with acrylates using benzoquinone as reoxidant and DMSO as solvent. The presentation of a new methodology for aerobic dehydrogenative Heck reactions of heterocycles with styrenes and the explanation about the negative effect of metallic co-oxidants represent the third chapter
Martinand-Lurin, Élodie. "Hétérocycles et réactions pallado-catalysées : développements méthodologiques, études mécanistiques et application en synthèse totale". Thesis, Paris 11, 2015. http://www.theses.fr/2015PA112018/document.
Testo completoThe development of new and more efficient synthetic methodologies, selective and eco-friendly seems to be an ongoing challenge as the interest in the heterocyclic compounds is important. All the studies performed during the last three years are divided in several axes in this field.First, the reactivity of N-(sulfonyl) and N-(sulfamoyl) aziridines as precursors of 1,3-zwitterionic species was explorated in order to obtain various 1-azaspiro[5.n]alkanes. The mechanism of the reaction has been studied by DFT calculations. The initial formation of the zwitterionic 1,3-dipole has been found to be the rate-determining step whereas the five-membered ring closure appeared to be the driving force.We tried to apply our expertise in the field of catalytic nitrene transfers (aziridination and C-H amination) to the total synthesis of pactamycin, highly functionalized aminocyclopentitol compound.Furthermore, the developments of a Passerini-Smiles/reduction/cyclization cascade and of a one-pot Passerini-Double-Smiles/SNAr sequence provide straightforward and efficient accesses to 1,4-benzoxazin-3-ones. These paths are complementary as they lead to regioisomers.Meanwhile, a new methodology based on Pd-catalyzed thiocyclopropanes ring opening gave thiochromenes. Due to their high synthetic potential, these compounds appear to be very promising scaffolds in heterocyclic chemistry.Finally, electrochemical and NMR studies coupled with DFT calculations have been done in order to elucidate the mechanism involved in the Pd-catalyzed couplings between an aryl halide, an isocyanide and a nucleophile
Johansson, Thomas, e Caisa Haraldsson. "”…men jag typ pallade inte med en massa ungar…” : Fem livsberättelser kring avhopp från gymnasieskolan". Thesis, Halmstad University, School of Teacher Education (LUT), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-3886.
Testo completoSyftet med denna studie är att genom fem livsberättelser tolka och förstå problematiken kring studieavbrott på fordonsprogrammet och barn- och fritidsprogrammet. Dessa gymnasieutbildningar är överrepresenterade i den statistik som visar avhopp i den undersökta kommunen. Rektorer och studievägledare för dessa program har intervjuats för att presentera en bakgrund kring problematiken. Som undersökningsverktyg används så kallad narrativ metod, vilket innebär att informanterna, fem ungdomar som hoppat av sina gymnasieutbildningar vid någon tidpunkt, fritt och med så liten styrning som möjligt får berätta om sina livsöden. Resultatet som analyserats utifrån tidigare forskning visar att det finns många olika anledningar och att det inte alltid är negativt att hoppa av sin utbildning. Dock visar sig två faktorer tydligare än andra, nämligen individuell mognad och skolans förmåga att upptäcka och diagnosticera elever som får svårigheter i utbildningen.
Mandel, Jérémie. "Approches synthétiques de tétrahydroisoquinoléines par cyclisation Pallado-Catalysée & synthèse de composés spirocétaliques par RRM". Phd thesis, Université de Haute Alsace - Mulhouse, 2010. http://tel.archives-ouvertes.fr/tel-00717736.
Testo completoEuzenat, Lisenn. "Dérivés aminoboranes monomères : des réactifs originaux pour la formation pallado-catalysée de liaisons carbone-bore". Rennes 1, 2003. http://www.theses.fr/2003REN1A010.
Testo completoPéron, Florent. "Activation C-H pallado-catalysée de N-tosylbenzamides : Application à la synthèse d'arènes diversement fonctionnalisés". Caen, 2014. http://www.theses.fr/2014CAEN2004.
Testo completoOver the past four decades, palladium-catalyzed cross-coupling reactions have profoundly revolutionized organic chemistry. More recently, transition-metal-catalyzed C-H bond functionalization of arenes has emerged as a new and promising methodology. This process allows the regioselective formation of C-C, C-N, C-O and C-X (X : halogen) bonds from more easily accessible starting materials precluding prior activation. As part of this PhD project, we used the N-tosylcarboxamide group as a versatile and transformable ortho-directing group to achieve palladium-catalyzed C-H bond functionalizations of arenes. In the first part, we developed C(sp2)-H arylation method of benzamides. The functional transformations of the N-tosylcarboxamide group were then accomplished including the synthesis of phenanthridinone structure, by C-H amination, which is a precursor of serotoninergic 5-HT4 receptors ligands synthesized in the laboratory. In the second part, the room temperature ortho-alkoxylation and -halogenation were performed using this directing group leading to the preparation of a wide variety of diversely ortho-functionalized N-tosylbenzamides. The last part of this project focused on the design and biological evaluation of new fluorinated 5-HT4 receptors ligands. This study highlighted the influence of the introduction of fluorine atom on the affinity of these ligands towards 5-HT4 receptors
Chamas, Zein El Abidine. "Chromophores pentacycliques azotés fluorescents : nouvelle cascade diastéréosélective pallado-catalysée et exploration de leurs propriétés biologiques". Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0079/document.
Testo completoThe aim of this work concerns the synthesis of a new family of aza-pentacyclic chromophore whose fluorescence properties can be modulated according to the functional groups present in the molecule. These chromophores were obtained through a cascade process between 2-formylbenzene boronic acid and 2,5-dihalopyridines. The cascade process is initiated by a palladium-catalyzed cross-coupling reaction and is followed by two successive nucleophilic cyclizations; the first cyclization performed on the pyridine nitrogen and the second occurred regioselectively on the adjacent carbon atom. This new cascade reaction allowed the formation of a pentacycle as a single regioisomer with four new bonds and two contiguous stereocenters with trans relationships. In addition, preliminary studies have shown that these polycyclic compounds have excellent fluorescence properties as well as biological properties that should enable us to extend the scope of these new chromophores to the medical field and molecular electronics
Saleh, Samer. "Méthodologie de synthèse pallado-catalysée en milieu non-usuel : alcynylation d'hétéroaromatiques et méthoxylation des alcynes". Thesis, Dijon, 2010. http://www.theses.fr/2010DIJOS078.
Testo completoThe properties of the ionic liquids such as their low melting point, their non-volatility, their thermal stability, and specially their ability to solubilize organic and inorganic compounds, made of them an interest media for organic synthesis. During this work, two principal research orientations were make it with the aim of the development of an efficient and immobilized palladium catalytic system which opens the way to recycling or continuous flow chemistry. The first part of this work was the study of the Heck alkynylation in [BMIM][BF4], using the system palladium monophosphines (PPh3 or imidazolium monophosphines) to make the coupling of a variety of activated and deactivated bromides and chlorides substrates with different terminal alkyne and diyne. The second part of this work was dedicated to the synthesis of new tiphophines ligand and their palladium complexes and the study of their potential in the methoxylation reaction in [BMIM][BF4]
Riflade, Benoît. "Applications catalytiques d'hybrides organiques et organométalliques de [P2V3W15O62]9- : oxydations contrôlées et allylations pallado-catalysées". Paris 6, 2012. http://www.theses.fr/2012PA066455.
Testo completoThis manuscript deals with the functionalization of the polyoxometalate [P2V3W15O62]9– by organic ligands. The first part is dedicated to a general introduction of POMs and their functionalization, especially the grafting of diol-amides into the Dawson type POM TBA5H4[P2V3W15O62]. The second part of this dissertation reports the synthesis of POM-diol-carbonyl organohybrids. A study of the chemoselective oxidation of sulfides by these hybrids was conducted. The final chapter describes complexation, by C-H activation, of POM-pyridine-diol-amide hybrids and palladium. These new complexes were subsequently successfully used as recyclable catalysts for sulfonimines and aldehydes allylation. Finally, an investigation about the folding of a tripeptide around the POM [1-P2W17O61]10– was carried out, using high field NMR. The spectra show the interaction between the organic moiety and the inorganic structure
Neilde, Kevin. "Pharmacomodulation anti-infectieuse en série 5-nitroimidazole : couplages pallado-catalysés et réactions par transfert monoélectronique". Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5502.
Testo completoThis work focuses on the synthesis of novel functionalized 5-nitroimidazoles possessing therapeutic activities. New 4-substituted-5-nitroimidazoles were obtained using Suzuki, Stille or Sonogashira cross-coupling using the 4-bromo-1,2 dimethyl-5-nitro-1H-imidazole. Moreover, access to functionalized products at both 2 and 4 positions of imidazole ring was developed thanks to a regioselective Suzuki cross-coupling on the 2,4-dibromo-1-methyl-5-nitro-1H-imidazole. Among cross-coupling products, those possessing chloromethyle substituent conjugated with the nitro group, were employed as starting material in the single electron transfer reaction (SRN1, TDAE) studies. Therefore, in a second part, we described the reaction between the 4-(3-chloroprop-1-ynyl)-1,2-dimethyl-5-nitro-1H-imidazole and several nitronate anions in SRN1 conditions. This reactivity was applied to the 2,4-bis(3-chloroprop-1-ynyl)-1-méthyl-5-nitro-1H-imidazole allowing the formation of bis-SRN1 products. TDAE methodology was implemented on the 4-(3-chloroprop-1-ynyl)-1,2-dimethyl-5-nitro-1H-imidazole, however poor yields were observed. TDAE strategy on the (E)-4-[4-(chlorométhyl)styryl]-1,2-diméthyl-5-nitro-1H-imidazole were more successful, addition products with different electrophilic species were obtained. Finally, mutagenic power and potential of reduction of synthesized 5-nitroimidazole were assayed. The anti-infective properties of these novel 5-nitroimidazole are currently under investigation
Neilde, Kevin. "Pharmacomodulation anti-infectieuse en série 5-nitroimidazole : couplages pallado-catalysés et réactions par transfert monoélectronique". Electronic Thesis or Diss., Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5502.
Testo completoThis work focuses on the synthesis of novel functionalized 5-nitroimidazoles possessing therapeutic activities. New 4-substituted-5-nitroimidazoles were obtained using Suzuki, Stille or Sonogashira cross-coupling using the 4-bromo-1,2 dimethyl-5-nitro-1H-imidazole. Moreover, access to functionalized products at both 2 and 4 positions of imidazole ring was developed thanks to a regioselective Suzuki cross-coupling on the 2,4-dibromo-1-methyl-5-nitro-1H-imidazole. Among cross-coupling products, those possessing chloromethyle substituent conjugated with the nitro group, were employed as starting material in the single electron transfer reaction (SRN1, TDAE) studies. Therefore, in a second part, we described the reaction between the 4-(3-chloroprop-1-ynyl)-1,2-dimethyl-5-nitro-1H-imidazole and several nitronate anions in SRN1 conditions. This reactivity was applied to the 2,4-bis(3-chloroprop-1-ynyl)-1-méthyl-5-nitro-1H-imidazole allowing the formation of bis-SRN1 products. TDAE methodology was implemented on the 4-(3-chloroprop-1-ynyl)-1,2-dimethyl-5-nitro-1H-imidazole, however poor yields were observed. TDAE strategy on the (E)-4-[4-(chlorométhyl)styryl]-1,2-diméthyl-5-nitro-1H-imidazole were more successful, addition products with different electrophilic species were obtained. Finally, mutagenic power and potential of reduction of synthesized 5-nitroimidazole were assayed. The anti-infective properties of these novel 5-nitroimidazole are currently under investigation
Riadi, Yassine. "Catalyse en synthèse organique : valorisation d'un biocatalyseur original et synthèse pallado-catalysée de nouveaux dérivés pyridopyrimidiniques". Phd thesis, Université d'Orléans, 2013. http://tel.archives-ouvertes.fr/tel-00952279.
Testo completoBrielles, Cédric. "Aminoboranes et cycloaminoboranes : des agents de borylation pour la formation de liaisons carbone-bore pallado-catalysée". Rennes 1, 2005. http://www.theses.fr/2005REN1S077.
Testo completoNassiri, Sarah. "Fonctionnalisations régiosélectives de N-oxyde de pyrazolopyridines via des réactions de C-H activation pallado-catalysées". Electronic Thesis or Diss., Orléans, 2024. https://theses.univ-orleans.fr/prive/accesESR/2024ORLE1007_va.pdf.
Testo completoThe activation of C-H bonds has emerged as an attractive approach for advancing the synthesis of novel heterocyclic systems with potential applications across diverse fields, particularly in biology and pharmacy.The primary aim of this PhD thesis was to develop innovative strategies for the selective functionalization of nitrogen-containing heterocycles through C-H activation reactions, employing transition metal catalysis.In the first part, we developed a synthesis methodology enabling the regioselective functionalization at the ortho position of the N-oxide function in 7-azaindazole derivatives. The reaction goes through anoxidative arylation reaction, with various arenes and heteroarenes as coupling partners. This approachenables precise control over the position of functionalization through optimized reaction conditions, which is crucial to design new compounds with enhanced properties whatever the domains of application.In the second part of our research, we conducted a series of experiments to perform a regioselectiveoxidative alkenylation on the pyridine moiety of 4-azaindazole and 7-azaindazole. Using the N-oxidefunction as an ortho directing group allowed us to exert control over the position of functionalization.In the last part, we presented our work aimed at establishing optimal conditions for a direct arylation reaction on various 7-azaindazole analogues. The use of the N-oxide function favoured the regioselectivity of the reaction towards the C6 position
Schmauck, Sebastian [Verfasser], Kai [Akademischer Betreuer] Tobias e Karina [Akademischer Betreuer] Pallagst. "Regionalparks als informelles Steuerungselement für den Natur- und Freiraumschutz in Europa / Sebastian Schmauck. Betreuer: Kai Tobias ; Karina Pallagst". Kaiserslautern : Technische Universität Kaiserslautern, 2015. http://d-nb.info/1075492777/34.
Testo completoVilliers, Pierre. "Synthèse d'un nouveau réactif d'hexavinylogation. Réactions de couplage croisé pallado-catalysées sur le 1,6-dibromohexa-1,3,5-triène". Rouen, 1999. http://www.theses.fr/1999ROUES051.
Testo completoNovoa, Alexandre. "Synthèse et fonctionnalisation d'exo-glycals : application à la préparation d'anti-tumoraux". Thesis, Nancy 1, 2010. http://www.theses.fr/2010NAN10006/document.
Testo completoThe objective of this work consists in the synthesis and functionnalization of exo-glycals toward potential anti-cancer compounds. On the one hand, the transformation of easily accessible exo-glycals to more elaborated ones using palladium cross-coupling reaction has been performed and offered a new route to disubstituted exo-glycals. The hydrogenation of these compounds gave original C-glycosides. On the other hand, the new functionnal exo-glycals have been developped to prepare biologically active compounds. Analogs of phenstatin have been obtained and tested for their cellular growth inhibition. Furthermore, a C-glycoside has been used as a scaffold for peptidomimetics synthesis against the tumor angiogenesis process
Skhiri, Aymen. "Réactivité des chlorures de benzènesulfonyle pour l'accès à des hétéroarènes et alcènes arylés via des réactions pallado-catalysées". Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1S080.
Testo completoIn this thesis we have been interested in the synthesis of arylated heterocycles via the activation of sp2 C-H bonds of heteroaromatics and to the synthesis of halo-substituted arylated alkenes using palladium-catalysis. The products obtained are considered to be molecular bricks which are of interest to biochemists as well as to the preparation of materials. The catalyst system Pd(MeCN)2Cl2/Li2CO3/dioxane allows the direct access to a wide variety of arylated molecules from heteroarenes or alkenes and benzenesulfonyl chlorides. We have developed a method for the direct β-arylation of selenophenes from selenophenes and benzenesulfonyl chlorides. We have also shown that the use of (poly)halogenated benzenesulfonyl chlorides makes it possible to synthesize, by Pd-catalyzed reactions, (poly)halo-substituted arylated heteroarenes, stilbenes or cinnamates
Goldschweer, Ulrike. "Gemeinsamkeit stiften, Distanz wahren : Kulinarische Motive in I. A. Gončarovs Reiseskizzen Fregat ‚Pallada’ (Die Fregatt e ‚Pallas’, 1858)". Universität Potsdam, 2013. http://opus.kobv.de/ubp/volltexte/2013/6794/.
Testo completoScott, James W. "Karina M. Pallagst, Raumordnung der Tschechischen Republik; Mittel- und Osteuropa vor dem Hintergrund europäischer Raumordnungsbestrebungen / [rezensiert von] James W. Scott". Universität Potsdam, 2002. http://opus.kobv.de/ubp/volltexte/2008/2476/.
Testo completoCORSI, ALESSANDRO. "TRA PALLADE E BACCO. PROFILO ISTITUZIONALE E ASPIRAZIONI UMANISTICHE NELLE ACCADEMIE LETTERARIE MILANESI DURANTE IL PERIODO SPAGNOLO (1548-1715)". Doctoral thesis, Università Cattolica del Sacro Cuore, 2019. http://hdl.handle.net/10280/59474.
Testo completoBy adopting a long-term period chronological perspective, this research analyses the institutional frameworks’ development of Milanese literary academies between their appearance in the city area and the beginning of Austrian government’s jurisdiction after the Peace of Utrecht. Key objectives of the phenomenon’s historical reconstruction are: the identification of patrons who promoted the academies’ dissemination; the description of associational networks made up by different intellectual elite groups operating in Milan; the contextualization of cultural projects - and resulting under covered political tensions - that influenced the academical pattern’s expansion process; finally, the gradual constitution of a peculiar Ambrosian identity related with this associations’ typology. The exegesis of the “Badia della Val di Blenio” academy’s literary production, deduced by the historical examine of the “Facchino” Cosme de Aldana’s bio-bibliographical experience, introduces the enquiry on students’ academical foundations, which were the result of the cooperation between the archiepiscopal curia, religious orders involved in the educational programs and representative bodies of Milanese patricians. Archival discoveries on Inquieti’s meetings contribute in depicting the progressive composition of a coherent Ambrosian “system of virtues” (the baroque reference point for academical activities), that got into a substantial crisis at the end of seventeenth century.
CORSI, ALESSANDRO. "TRA PALLADE E BACCO. PROFILO ISTITUZIONALE E ASPIRAZIONI UMANISTICHE NELLE ACCADEMIE LETTERARIE MILANESI DURANTE IL PERIODO SPAGNOLO (1548-1715)". Doctoral thesis, Università Cattolica del Sacro Cuore, 2019. http://hdl.handle.net/10280/59474.
Testo completoBy adopting a long-term period chronological perspective, this research analyses the institutional frameworks’ development of Milanese literary academies between their appearance in the city area and the beginning of Austrian government’s jurisdiction after the Peace of Utrecht. Key objectives of the phenomenon’s historical reconstruction are: the identification of patrons who promoted the academies’ dissemination; the description of associational networks made up by different intellectual elite groups operating in Milan; the contextualization of cultural projects - and resulting under covered political tensions - that influenced the academical pattern’s expansion process; finally, the gradual constitution of a peculiar Ambrosian identity related with this associations’ typology. The exegesis of the “Badia della Val di Blenio” academy’s literary production, deduced by the historical examine of the “Facchino” Cosme de Aldana’s bio-bibliographical experience, introduces the enquiry on students’ academical foundations, which were the result of the cooperation between the archiepiscopal curia, religious orders involved in the educational programs and representative bodies of Milanese patricians. Archival discoveries on Inquieti’s meetings contribute in depicting the progressive composition of a coherent Ambrosian “system of virtues” (the baroque reference point for academical activities), that got into a substantial crisis at the end of seventeenth century.
Petschlies, Marcus [Verfasser], Michael [Akademischer Betreuer] Müller-Preußker, Elisabetta [Akademischer Betreuer] Pallante e Friedrich [Akademischer Betreuer] Jegerlehner. "Non-perturbative investigation of current correlators in twisted mass lattice QCD / Marcus Petschlies. Gutachter: Michael Müller-Preußker ; Elisabetta Pallante ; Friedrich Jegerlehner". Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://d-nb.info/1036918815/34.
Testo completoKorzec, Mateusz. "Synteza bloków budulcowych dla farmacji i chemii metodą katalizy heterogenicznej w układzie nano-Pd/Cu". Doctoral thesis, Katowice : Uniwersytet Śląski, 2016. http://hdl.handle.net/20.500.12128/714.
Testo completoNanocatalytic system has been investigated in synthesis of selected compounds with potential application in pharmacy and chemistry. The study goal was to determinate the catalytic activity of various bimetallic materials consisting of Pd nanoparticles on the target carriers, such as Ag, AgO, Cu, CuO, Ni. The assays were performed in Sonogashira coupling as a model reaction. This allowed to select the active catalyst, i.e., nanosized palladium particles dispersed on the electrolytic copper (PdNPs/Cu). The method for the preparation of the catalyst and its modification was investigated. In a series of further studies different types of reactions using PdNPs/Cu catalyst were tested. The results that were obtained show high activity of the studied catalyst in the reactions of terminal alkynes with halogen derivatives. The examples of such reactions are: Sonogashira and Cadiota-Chodkiewicz cross coupling and cycloaddition azide-alkyne. In the course of the studies, a potential factors affecting high catalytic activity PdNPs/Cu were identified. Sonogashira coupling products were used for the preparation of the new styrylquinolines which have been described as new group of fluorescent dyes suitable for microscopic imaging of biological structures. The structure of all compound was confirmed by 1H and 13C NMR, ESI-MS analyses, while the purity of a compound was confirmed by: ED-XRF, ICP-MS, HPLC. The obtained catalysts were characterized by means of XPS, TEM, SEM + EDX, XRD.
Livecchi, Marion. "Synthèse pallado-catalysée de 5-azaindoles et évaluation de leur activité inhibitrice sur les protéines kinases CK2 et Pim-1". Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05P616.
Testo completoProtein kinases represent promising targets for anti-cancer drug design. In 2003, inhibitors of two of these enzymes, CK2 and Pim-1, were identified by the screening of the Curie Institute/CNRS small-molecule library. The aim of this thesis was to synthesize derivatives of these hits with a 5-azaindole scaffold in order to optimize their biological activity. As the synthesis of such molecules was not reported in the literature, efficient and flexible procedures were developed to access to these structures. Diarylated symmetrical 5-azaindoles were thus prepared by palladium-catalyzed heteroannulation from 4-aminopyridines derivatives. The methodology was subsequently extended to silylalkynes and led to monoarylated products through domino sila-Sonogashira/5-endo cyclization. Finally, a one-pot Sonogashira coupling/aminopalladation/reductive elimination afforded unsymmetrical compounds with a total control of the regioselectivity. Using these methodologies, 70 functionalized molecules were easily prepared. Their cytotoxicity and biological activity as CK2 inhibitors were then evaluated. A structure-activity relationship study was performed, which led to the identification of two key structural elements for the CK2 inhibitory potency of 5-azaindoles
Raffa, Guillaume. "Hétérocyclisations électrophiles et pallado-catalysées d’α-alcynyl β-alcoxyénones (et systèmes apparentés) : nouvelles voies d’accès à des dérivés furaniques tétrasubstitués". Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10236.
Testo completoKoubachi, Jamal. "Développement et application des réactions d'arylations et d'alcénylations directes pallado-catalysées pour la synthèse d'imidazo[1,2-a]pyridines diversement substituées". Orléans, 2008. http://www.theses.fr/2008ORLE2021.
Testo completoJulienne, Delphine. "Etude de la réaction de couplage C-P pallado-catalysée : Accès à des alcénylphosphines P-stéréogéniques énantioenrichies par catalyse asymétrique". Caen, 2008. http://www.theses.fr/2008CAEN2059.
Testo completoA methodology dealing with the preparation of enantioenriched P-stereogenic alkenylphosphines by asymmetric catalysis has been proposed. It is based on the palladium C-P cross-coupling reaction between secondary phosphine-boranes and alkenyltriflates. This study was carried out in racemic and enantioselective versions. In the racemic version, a general and efficient method enabling the coupling of alkenyltriflates was developped. Chiral or achiral diaryl-, alkylaryl- and dialkylalkenylphosphines were easily prepared under mild conditions, using a weak base (K2CO3 or K3PO4) and a mild thermal activation (60 to 80 °C). With the cheaper but less reactive alkenyltosylates, higher temperatures (80 to 110 °C) were required to perform the coupling. The alkenylphosphines were isolated in good yields (50 to 90%). In the enantioselective version, a catalytic system enabling to perform the coupling efficiently was designed. It involves the palladium catalyst [(S,S)-Me-DUPHOS]PdCl2. Optimization of the other parameters allowed us to synthesize an enantioenriched alkenylphosphine with an enantiomeric excess of 55%. A mechanistic study has enabled us to propose a mechanism and to confirm the individual steps in the catalytic cycle. The oxidative addition complex and the transmetallation adduct were fully characterized. A dynamic kinetic resolution was proposed to rationalize the enantioselectivity
Caesar, Beate Dorothea [Verfasser], e Karina [Akademischer Betreuer] Pallagst. "The Influence of the Trans-European Transport Networks and European Territorial Cooperation on Cross-Border Transport / Beate Dorothea Caesar ; Betreuer: Karina Pallagst". Kaiserslautern : Technische Universität Kaiserslautern, 2018. http://d-nb.info/1155166183/34.
Testo completoMathias, Fanny. "Synthèse et évaluation biologique de nouveaux nitroimidazoles : challenges et recherche de nouvelles relations structure-activité". Electronic Thesis or Diss., Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0591.
Testo completoWe have developed in this work the synthesis and the biological evaluation of novel nitromidazoles with anti-infectious potentialities. In the first three parts, we discussed the biological properties of 5-nitroimidazole scaffold, and the synthesis of new compounds functionalized at 2- and 4-position in order to improve the activity on metronidazole-resistant strains, while controlling mutagenicity. We developed a regioselective Suzuki-Miyaura cross- coupling reaction at 4-position of 2,4-dibromo-1-methyl-5-nitro-1H-imidazole, followed by a second Suzuki-Miyaura or Sonogashira cross-coupling reaction at 2-position by a "one-pot" sequential process. This methodology has enabled us to obtain 30 new products which were tested for their antibacterial and antiparasitic properties. Twelve compounds were synthesized by TDAE methodology on {4- [4- (chloromethyl) phenyl]} -1,2-dimethyl-5-nitro-1H-imidazole. In the last part, we initiated a work of pharmacomodulation in imidazooxazole series, scaffold well-known for its antituberculous and antileishmanial properties. We have described the synthesis and the biological evaluation of 6-functionalized 5-nitroimidazooxazole and 7-nitro-2,3-dihydroimidazo [5,1-b]oxazole derivatives. We have presented some CH-arylation assays on 2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole to obtain 5-functionalized 6-nitroimidazooxazole derivatives
Xuárez, Marill Lisbet. "Synthèse par ortho-métallation et couplage pallado-catalysés de nouveaux dérivés de bêta-carbolines actifs au niveau du système nerveux central". Paris 11, 2006. http://www.theses.fr/2006PA112189.
Testo completoThe aim of this thesis is the synthesis of new derivatives of β-carbolines interacting with the Central Nervous System (CNS) especially at the level of the GABAA receptor. In the first chapter, a new process for the synthesis of a β-carboline-3,4- γ-lactone, (R, S)-10-hydroxymethylbutanolide[3,4-c]-β-carboline using the technique of ortho-directed metallation, allows its preparation in a few steps and in a reproducible fashion. This result confirms the value of the ortho-metallation reaction for the introduction of substituants at the C-4 position of 3-carboxy-β-carbolines. In the second chapter, starting from the 4-iodo-β-carboline-3-carboxamide derivative prepared by ortho-metallation, the Suzuki coupling reaction was used to prepare a series of 4-aryl-β-carbolines-3-carboxamides, some of which were shown to bind to the GABAA receptor. In the third chapter, intramolecular cyclization by CH-ortho activation catalysed by palladium allowed the
Naret, Timothée. "Réactions de couplage pallado-catalysées entre des N-tosylhydrazones et des hétérocycles : application à la synthèse d'analogues de l'isoCombretastatine A-4". Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS443.
Testo completoThis manuscript reported the synthesis and the biological evaluation of analogs of Combretastatin A-4, a natural product with antivascular and cytotoxic properties.In a first hand, methodological studies were realized around the palladium-catalyzed cross-coupling reactions between N-tosylhydrazones and aryl and heteroaryl halides in order to develop synthetic tools to prepare libraries of molecules. These studies conducted to the synthesis of (1-arylvinyl)benzimidazoles from imidates, N-tosylhydrazones and d'amines and to the functionalization of nitrogen-containing heterocycles and coumarines.In the other hand, fluorated and heterocyclic analogs of isoCombretastatin A-4 (isoCA-4) were developed. After the biological evaluation of these new compounds, five molecules exhibited antiproliferative activities against cancer cell lines with nanomolar range. Excellent results of tubulin polymerization inhibition were also observed.These works contributed to develop new processes for an easy access of highly substituted compounds. Moreover, biological evaluation of new series of isoCA-4 analogs provides to a better understanding of ligands of colchicine binding sites with structure-activity relationship studies
Place, Matthieu. "Méthodologies de synthèses d'hétérocycles bicycliques (6-5) et (5-5). Application à la conception d'inhibiteurs de kinases impliquées en oncologie et dans les maladies du système nerveux central". Thesis, Orléans, 2017. http://www.theses.fr/2017ORLE2056.
Testo completoSince the early 2000s, precise knowledge of kinome has induced the emergence of novel therapies targeting kinases involved in several kinds of pathologies in oncology and nervous central systems disorders.In order to target original kinases of interest identified in this work, we have developed diversity-oriented synthesis to create new high-valuable heterocycles. We have focused our efforts on the design and functionalization of [6-5] or [5-5] fused ring bicycles. Those chemical species representing a great pathway tocreate competitive inhibitors of ATP; the natural substrate of kinases.First-of-all, we have worked on imidazo[1,2-b]pyridazines and then on [1,2,4]triazolo[4,3-b]pyridazinesscaffolds, to create more active and selective HASPIN kinase inhibitors, a new hot-target in oncology.Then, we have pursued previous laboratory studies on imidazo[2,1-b][1,3,4]thiadiazoles. Based on a well-built methodology, we have synthesized severals DYRK1A and CLK1 kinases inhibitors involved in neurodegenerative disorders, as Alzheimer’s disease. Thus, through original imidazothiadiazoles analogues,we have proposed synthetic methodologies to design these novel heterocycles allowding esay pharmacomodulations.These medicinal chemistry projects have been undertaken to improved knowledge of structure-activityrelashionship, and providing novel strong inhibitors of HASPIN, DYRK1A or CLK1 kinases
Chaulet, Charlotte. "Synthèse et étude du mécanisme d'action de nouveaux analogues de la thalidomide, dérivés du noyau 1H-pyrrolo (2, 3-b) pyridine, sur la modulation des cellules NK et la production des cytokines TNF-a et IL-6". Thesis, Tours, 2010. http://www.theses.fr/2010TOUR3802/document.
Testo completoThalidomide is a sedative hypnotic on the market for the first time in Germany in October 1957 and subsequently sold widely in the 46 countries under 51 different trade names. It was also used as antiemetic in pregnant women and from the Christmas Day of 1956, a first child with phocomelia born, six months before placing on the market. Thalidomide was withdrawn from the market in late 1961, because of its devastating effects on fetal development. Many mechanisms of action of thalidomide embryopathy have been reported, including an antiangiogenic effect with inhibition of neurovascularisation during limb development during fetal life. Subsequently, thalidomide has emerged as a treatment of many diseases. It was also demonstrated its ability to induce an increase or inhibition of expression of chemokines or growth factor. The development of new molecules like more effective remains the focus of many research studies. Based on studies on the regulation of cytokines production and modulation of NK cells by thalidomide and its analogs, we worked on the 1H-pyrrolo [2,3-b] pyridine. This study led us to functionalize 7-azaindole on various positions and by different organic synthesis: desulfonylation, Michael addition, peptide coupling… These synthetized compounds have been tested in pharmacologic studies