Tesi sul tema "Oxygen therapy"
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Wijesinghe, Meme. "Oxygen therapy in respiratory disorders". Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/2511.
Testo completoMaia, Mariana Cervaens Costa. "Hyperbaric oxygen therapy in sports medicine". Doctoral thesis, [s.n.], 2013. http://hdl.handle.net/10284/4224.
Testo completoAs lesões desportivas são um grande problema no que diz respeito à sua rápida reabilitação. Inúmeros estudos tentam encontrar a técnica mais rápida capaz de acelerar o processo da recuperação. A oxigenoterapia hiperbárica (OTH) é a aplicação de 100% de oxigénio numa câmara hiperbárica a pressões mais elevadas do que o nível do mar. A inalação de OTH comporta-se como um fármaco multifacetado dotado de efeitos anti-isquémicos, anti-hipóxicos, anti-edematosos, pós-lesão e anti-infecciosos. Portanto, o objetivo desta tese foi analisar a influência da OTH na recuperação de lesões desportivas, como contusão muscular e do ligamento cruzado anterior (LCA) pós ruptura. Em primeiro lugar, verificou-se se a aplicação de OTH melhorou as propriedades biomecânicas, tais como rigidez, alongamento máximo e peso máximo, dos gastrocnémios de ratos após induzir contusão muscular. Em segundo lugar, era de nosso interesse analisar, após de se ter induzido uma contusão muscular nos gastrocnémios dos ratos, a influência da OTH na bioenergética mitocondrial avaliada através do consumo de oxigénio e potencial transmembranar e susceptibilidade à indução do poro de transição de permeabilidade mitocondrial, em mitocôndrias isoladas. Finalmente, no último trabalho experimental, tentou-se verificar se a aplicação de OTH tem a capacidade de melhorar a neovascularização, por meio da análise do factor de crescimento do endotélio vascular (VEGF), bem como analisar a proliferação e a produção de proteína, em coelhos com ruptura do LCA. A OTH parece desempenhar um papel importante na recuperação de lesões musculares, mais especificamente, na contusão muscular em ratos, melhorando as propriedades biomecânicas musculares, tais como a rigidez e peso máximo e na bioenergética mitocondrial, onde o tempo até que o inchaço na mitocôndria iniciasse em grande escala foi menor no grupo submetido a OTH, assim como a amplitude de inchaço foi maior, o que atrasou a apoptose mitocondrial. Contudo, em relação à ruptura do LCA, a OTH promoveu a neovascularização, activando VEGF, mas no entanto, contribuindo para o aumento da espessura da cápsula. VII Palavras-chave: Oxigenoterapia hiperbárica, gastrocnémios, contusão muscular, propriedades biomecânicas, bioenergética mitocondrial, ligamento cruzado anterior, neovascularização, colagénio tipo I. Sports injuries is a major problem what concerns to its rapid rehabilitation. There is innumerous attempting to find the faster technique to apply to the injured ones to accelerate its recovery. Hyperbaric oxygen therapy (HBO) is the application of 100% oxygen in a hyperbaric chamber at pressures higher than sea level. The inhalation of HBO has already shown that behaves like a multifaceted drug endowed with anti-ischemic, anti-hypoxic, anti-edematous, pro-healing and anti-infective effects. Therefore, the objective of this thesis was to analyze the influence of HBO in the recovery from sports injuries such as muscle contusion and anterior cruciate ligament (ACL) rupture. Firstly, it was verified if HBO improved the biomechanical properties, such as hardness, maximum elongation and maximum weight, of rats’ gastrocnemius after inducing muscle contusion. Secondly, it was of our interest to analyze skeletal muscle mitochondrial energetic of rats’ gastrocnemius after induced muscle contusion, by determining end points related to oxygen consumption, transmembrane electric potential and permeability transition pore susceptibility in isolated mitochondria. At last, our last experimental work aimed to verify if HBO has the ability to improve neovascularization, through the analysis of vascular endothelial growth factor (VEGF) as well the proliferation and protein production, of rabbit ruptured ACL. HBO seems to play an important role in the recovery of muscle injuries, more specifically, muscle contusion in rats, by improving muscle biomechanical properties, such as hardness and maximum weight and in mitochondria energetic, where the time until large scale swelling initiates in mitochondria was lower in HBO and the swelling amplitude was higher, which delayed mitochondria apoptosis. However, concerning to ACL rupture, HBO increased neovascularization by activating VEGF, contributing for the increasing of capsule thickness. Les lésions sportives sont un grand problème en ce qui concerne la rapidité de sa réhabilitation. De nombreux études essayent de trouver la plus rapide et moins douloureuse technique capable d’accélérer le processus de récupération. L’oxygénothérapie hyperbare (OHB) consiste à l’inhalation de 100% d’oxygène dans un caisson étanche avec une pression plus élevée que celui de la mer. Il a été démontré que l’inhalation de l’OHB se comporte comme une drogue à multiple facette, qui permet d'agir sur l'ischémie tissulaire qu'elle qu'en soit la cause : vasculaire, traumatique, toxique, ou infectieuse. Pourtant, l’objectif de cette étude a été d’analyser l’influence de l’OHB dans la récupération des lésions sportifs, l’ecchymose du ligament croisé antérieur post rupture. Dans un premier temps, on a vérifié si l’utilisation de l’OHB améliore les propriétés biomécaniques, comme la rigidité, l’étirement maximum et le poids maximum, des Gastrocnémiens chez les rats après induire une ecchymose. Deuxièmement, cela été dans notre intérêts d’analyser, après induire une ecchymose des Gastrocnémiens chez les rats, l’influence du OBH dans la bioénergétique mitochondriale, évalué à travers la consommation d’oxygène, le potentiel transmembranaire et la susceptibilité d’induction du pore de transition de perméabilité mitochondrial, des mitochondries isolés. Pour finir, lors du dernier travail expérimental, nous avons essayé de vérifier si l’application de l’OHB a la capacité d’amélioré la néo vascularisation, en analysant le facteur de croissance de l’endothélium vasculaire (en anglais Vascular endothelial growth factor, VEGF), en analysant aussi la prolifération et la production de protéine, sur des lapins avec rupture du LCA. L’OHB semble avoir un rôle important dans la récupération des lésions musculaires, plus précisément sur l’ecchymose chez les rats, améliorant ainsi les propriétés biomécaniques musculaires, comme la rigidité, le poids maximum et la bioénergétique mitochondriale. Le temps pour que l’oedème dans la mitochondrie arrive à grande échelle a été plus faible dans le groupe soumis à l’OHB, comme l’amplitude de l’oedème fut plus grand, ce qui a retardé XI l’apoptose mitochondrial. Toutefois, en ce qui concerne la rupture du LCA, l’OHB a promu la néo vascularisation, activant le VEGF, contribuant à une capsule épaisse.
Kunin, Wendy. "Hyperbaric oxygen therapy following arthroscopic meniscectomy surgery". Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80308.
Testo completoIobbi, Mario Gabriel. "Saturation driven flow controller for oxygen therapy". Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/43396.
Testo completoHodge, Rachel Elizabeth. "Coping During Hyperbaric Oxygen Therapy: Predictors and Intervention". Thesis, University of Canterbury. Psychology, 2008. http://hdl.handle.net/10092/2167.
Testo completoPerrin, Kyle Gareth. "High concentration oxygen therapy in acute respiratory disease". Thesis, University of Canterbury. Health Sciences Centre, 2010. http://hdl.handle.net/10092/5079.
Testo completoMorozoff, Edmund Pavel. "Modelling and fuzzy logic control of neonatal oxygen therapy". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/mq24210.pdf.
Testo completoRuiz, González Rubén. "New strategies in antimicrobial photodynamic therapy and singlet oxygen detection". Doctoral thesis, Universitat Ramon Llull, 2013. http://hdl.handle.net/10803/119556.
Testo completoTres estrategias destinadas a aportar una mayor perspectiva en el campo de la terapia fotodinámica antimicrobiana componen la primera parte de la tesis. En una primera aproximación, seis fotosensibilizadores catiónicos, con distinta carga eléctrica neta y estructura, han sido caracterizados en disolución y sus propiedades fotoinactivadoras probadas contra diferentes tipos de microorganismos. En una segunda aproximación, conjugados entre un fotosensibilizador y el péptido antimicrobiano Apidaecina 1b han sido analizados fotofísica y mecanísticamente, y sus propiedades correlacionadas con su habilidad fotosensibilizadora en bacterias. En la última aproximación, dos proteínas fluorescentes –TagRFP y miniSOG- han sido expresadas en E. coli y se ha estudiado su fototoxicidad así como su mecanismo de acción. Además, se ha reevaluado y estudiado en detalle la capacidad de miniSOG para fotosensibilizar la formación de oxígeno singlete. En la segunda parte de la tesis, el interés se ha centrado en la detección de oxígeno singlete. En la primera sección, se ha evaluado la capacidad de detección en disolución de una nueva díada compuesta por un naftoxazol y una trampa química de oxígeno singlete. En la última sección, se desarrolla, prueba y discute la viabilidad de nanopartículas de poliacrilamida como plataforma potencial para detección de oxígeno singlete en sistemas intracelulares.
Three strategies addressed to give further scope on to the antimicrobial photodynamic therapy field comprise the first part of the thesis. In a first approach, six cationic photosensitisers varying in the net electrical charge and structure have been characterised in solution and their photoinactivation skills have been tested against different types of microorganisms. In a second approach, conjugates between a photosensitiser and the antimicrobial peptide Apidaecin 1b have been analysed in a photophysical and mechanistic way, and their properties have been correlated with their bacterial photoinactivation ability. In the last approach, two fluorescent proteins –namely TagRFP and miniSOG- have been expressed in E. coli and their phototoxicity has been studied and characterised mechanistically. Moreover, the capacity of miniSOG to photosensitise singlet oxygen formation has been revisited and studied in detail. In the second part of the thesis, focus has been shifted towards singlet oxygen detection. In the first section, the probing ability of a new dyad comprising a naphthoxazole moiety plus a singlet oxygen chemical trap has been evaluated in solution. In the last section, we develop, test, and discuss the feasibility of a polyacrylamide nanoparticle scaffold as a potential platform for singlet oxygen detection in intracellular systems.
Vudiniabola, Sunia. "Hyperbaric oxygen therapy for the treatment and prevention of osteoradionecrosis /". Title page, contents and summary only, 1997. http://web4.library.adelaide.edu.au/theses/09DM/09dmv986.pdf.
Testo completoGermain, Geneviève. "Effect of hyperbaric oxygen therapy on exercise-induced muscle injury". Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29504.
Testo completoSkelton, Deborah. "The effects of hyperbaric oxygen therapy on acute ankle sprains /". Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31140.
Testo completoCashman, Lauren E. "Oxygen Therapy in Malawi: Revising Oxygen Concentrator Filtration and Use for Improved function in Low-Resource Hospitals". Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/79132.
Testo completoMaster of Science
The quality of healthcare in low-resource countries is often limited by the environment, lack of funds, staff availability, electricity availability, and more. In the words of a Malawian physician, medicine can feel like improvisation, wherein one must make due with available resources rather than desired resources. One prevalent problem among low-resource hospitals is the functionality and longevity of medical equipment. A large percentage of all medical equipment in Malawian hospitals is donated, resulting in a wide spectrum of models, necessary spare parts, and functionality. These machines can break quickly due to heavy use prior to donation, missing user and maintenance manuals, and a lack of replacement parts. Thus, finding necessary life-saving equipment in Malawian hospital wards can be a challenge. One such piece of equipment is the oxygen concentrator. This device fills many roles in low-resource hospitals, but in many Malawian hospitals it is the most frequently malfunctioning piece of equipment. A survey was used in hospitals in Malawi’s Central and Southern Regions to collect information on why oxygen concentrators malfunction. Common reported causes of malfunction were oxygen concentrators overheating due to clogged exhaust vents, and the unavailability of necessary disposable filters. A stand made from locally-available materials was developed to improve oxygen concentrator ventilation. Replaceable filter alternatives were researched, designed, constructed, and tested, made from housing materials and filter materials available in Malawi or continental Africa. A primary source of difficulty for low-resource hospitals is dependence on more developed nations for supplies and aid. This work suggests that designing materials from locally-available materials can lessen this dependency and make necessary medical materials more accessible. Collaboration with material suppliers and engineers in Malawi can provide sustainable designs and systems to help hospitals access the supplies they need to service oxygen concentrators and other equipment.
Lau, Wai-lee Cherry. "Outcomes of COPD patients receiving long term oxygen therapy a retrospective cohort study /". Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23316767.
Testo completoQuine, David. "Studies and observations on different kinds of oxygen monitoring, oxygen therapy, and associated morbidities in preterm infants". Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/25105.
Testo completoMcGavock, Jonathan M. "The effect of hyperbaric oxygen therapy on aerobic performance following fatigue". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0027/MQ50544.pdf.
Testo completoCarnochan, Fiona Mary. "The metabolic consequences of inflammation and the effects of oxygen therapy". Thesis, University of Aberdeen, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305435.
Testo completoAl-Hadi, Hadil. "The effect of Hyperbaric Oxygen Therapy on osteoclast and osteoblast function". Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1614.
Testo completoPhilips, Alyssa. "EFFECTS OF HYPERBARIC OXYGEN ON STAPYLOCOCCUS AUREUS". OpenSIUC, 2018. https://opensiuc.lib.siu.edu/theses/2328.
Testo completoBennett, Michael Heywood Prince of Wales Clinical School UNSW. "The evidence basis of diving and hyperbaric medicine - a synthesis of the high level clinical evidence with meta-analysis". Awarded by:University of New South Wales. Prince of Wales Clinical School, 2006. http://handle.unsw.edu.au/1959.4/24243.
Testo completoJackson, Laura. "Oxygen-regulated gene expression in Escherichia coli and hypoxia-targeted gene therapy". Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414676.
Testo completoAl-mzaiel, Anwar J. "Mechanisms by which hyperbaric oxygen therapy may resolve inflammation in chronic wounds". Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1945.
Testo completoKelly, Carol Ann. "Patients' and healthcare professionals' perceptions of oxygen therapy : an interpretative phenomenological analysis". Thesis, Edge Hill University, 2014. http://repository.edgehill.ac.uk/6432/.
Testo completoMuhonen, Arja. "Distraction osteogenesis of irradiated rabbit mandible with and without hyperbaric oxygen therapy". Turku : Turun Yliopisto, 2002. http://catalog.hathitrust.org/api/volumes/oclc/50131839.html.
Testo completoMostert, Lelane. "Central oxygen pipeline failure". Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86313.
Testo completoENGLISH ABSTRACT: Case Report - A case is described of central oxygen pipeline failure that occurred at a large academic hospital and its subsequent implications for managing the situation. Literature review - The literature review undertaken focused on the current state of affairs with regards to anaesthetic staff's knowledge of and preparedness for the management implications of central oxygen pipeline failure. The events I describe below demonstrate a significant deficiency in the staff’s understanding of and training for the crisis, which should be remedied to improve patient safety. Specific measures are suggested in the literature to prevent such incidents and guidelines are available to manage central oxygen pipeline failure. These are reviewed in this study. Recommendations - This study attempts to bring together the most critical aspects that need to be addressed to safely manage similar future incidents. Prevention should include measures to implement clearly stated disaster management plans and increased awareness with regards to the medical gas pipeline system (MGPS), simulation training, efficient alarm systems, personally conducted routine evaluations of equipment and emergency backup systems by anaesthesiologists and effective communication between hospital staff. Careful planning and successful coordination during maintenance and modification of the medical gas pipeline system, using piston-type or air-driven, rather than oxygen-driven, ventilators and optimal design of the hospital bulk oxygen system can contribute to reduce risks. In the event of central oxygen pipeline failure a specific sequence of actions should be taken by the anaesthesiologist and a clear institutional operational policy is described.
AFRIKAANSE OPSOMMING: Gevalsbeskrywing - 'n Geval van sentrale suurstoftoevoerversaking, wat plaasgevind het by 'n groot opleidingshospitaal, word bespreek. Daar word ook gekyk na die praktiese gevolge met betrekking tot die hantering van die situasie. Literatuurstudie - 'n Literatuurstudie is aangepak met die doel om te fokus op die huidige toedrag van sake betreffende narkosepersoneel se kennis en paraatheid in die hantering van sentrale suurstoftoevoerversaking. 'n Wesenlike gebrek aan begrip en opleiding aangaande hierdie onderwerp is geïdentifiseer – areas wat, met die nodige aandag, verbeter kan word ten einde die welstand van pasiënte te verseker. Spesifieke voorkomende maatreëls en hanteringsriglyne word voorgestel deur die literatuur en word gevolglik hersien in hierdie studie. Aanbevelings - Hierdie studie poog om kernaspekte aan te raak ten einde soortgelyke toekomstige voorvalle veilig en optimaal te kan hanteer. Voorkomende maatreëls behels onder meer die daarstelling van duidelik verstaanbare noodplanne, verbeterde bewustheid aangaande die mediese gaspypsisteem, simulasie-opleiding, doeltreffende alarmstelsels, effektiewe kommunikasie tussen hospitaalpersoneel, sowel as narkotiseurs wat self roetine-evaluasies van hul narkosetoebehore en -noodtoerusting uitvoer. Noukeurige beplanning en neweskikking tydens herstelwerk of werk aan die mediese gaspypsisteem, die gebruik van suierventilators (of dan lugaangedrewe in plaas van suurstofaangedrewe ventilators) en die optimale uitleg van 'n hospitaal se suurstoftoevoer, kan bydra om die risiko's te beperk. In die geval van sentrale suurstoftoevoerversaking behoort die narkotiseur stapsgewyse aksie te neem. 'n Duidelike institusionele noodbeleid word ook omskryf.
Ragàs, Amalrich Xavier. "Singlet Oxygen in Antimicrobial Photodynamic Therapy: Biological effects, Mechanistic Studies and Future Directions". Doctoral thesis, Universitat Ramon Llull, 2010. http://hdl.handle.net/10803/9302.
Testo completoPer altra banda, s'han estudiat les cinètiques de formació i decaïment d'oxigen singlet (1O2) en E. coli mitjançant un espectrofotòmetre ultrasensible a l'infraroig proper amb resolució temporal per sota del microsegon. Els resultats ens permeten profunditzar en el mecanisme de l'APDT, és a dir, en la localització del fotosensibilitzador (PS) en el bacteri i la reactivitat de l'1O2. Per un costat, l'entorn del PS canvia quan la distribució de les càrregues catiòniques varia. Per l'altre, en funció del lloc de formació, l'1O2 reacciona amb l'entorn proper o és capaç d'escapar fora de les cèl·lules.
En tercer lloc, també s'ha estudiat, mitjançant sondes fluorescents i tècniques amb resolució temporal, l'habilitat d'una proteïna fluorescent per produir espècies reactives d'oxigen, actuant com a agents fotosensibilitzadors genèticament codificats. Així, s'ha calculat per primera vegada el rendiment quàntic de formació d'1O2 obtenint un valor similar al del cromòfor sintètic de les GFPs.
Finalment, s'ha investigat mitjançant l'espectrofotòmetre en l'infraroig proper l'efecte plasmó produït per films d'illes de plata sobre l'1O2, demostrant un increment màxim en la luminescència d'1O2 a 1270 nm al voltant de 30 vegades en alguns casos.
En esta tesis se ha evaluado el uso la terapia fotodinámica antimicrobiana (APDT) como alternativa a los antibióticos. Inicialmente, se ha demostrado, in vitro y en un modelo de quemaduras en ratón, el potencial de las fenotiazinas, y más concretamente del nuevo azul de metileno, para inactivar una bacteria resistente a antibióticos como Acinetobacter baumanii. Además, también se ha investigado el potencial de los porficenos aril catiónicos como agentes fotosensibilizadores para APDT in vitro e in vivo, inactivando exitosamente distintos tipos de bacterias gram positivas y negativas, así como hongos.
Por otro lado, se ha estudiado las cinéticas de formación y decaimiento de oxígeno singlete (1O2) en E. coli mediante un espectrofotómetro ultrasensible en el infrarrojo cercano con resolución temporal por debajo del microsegundo. Los resultados nos permiten profundizar en el mecanismo de la APDT, es decir, en la localización del fotosensibilizador (PS) en la bacteria y la reactividad del 1O2. Por un lado, el entorno del PS cambia cuando la distribución de las cargas catiónicas varía. Por otro lado, en función del lugar de formación, el 1O2 reacciona con el entorno cercano o es capaz de escapar fuera de las células.
En tercer lugar, también se ha estudiado, mediante sondas fluorescentes y técnicas con resolución temporal, la habilidad de una proteína fluorescente para producir especies reactivas de oxígeno, actuando pues como agentes fotosensibilizadores genéticamente codificados. Así, se ha calculado por primera vez el rendimiento cuántico de formación de 1O2 mostrando un valor similar al del cromóforo sintético de las GFP.
Finalmente, se ha investigado mediante el espectrofotómetro en el infrarojo cercano el efecto plasmon producido por films de islas de plata sobre 1O2, observando un incremento máximo de la luminiscencia de 1O2 a 1270 nm alrededor de 30 veces en algunos casos.
In this thesis, the use of antimicrobial photodynamic therapy as alternative to antibiotics has been assessed. First, the potential of phenothiazinium dyes, and specifically new methylene blue, to inactivate multidrug-resistant strains has been demonstrated against Acinetobacter baumanii in vitro and in a mouse burn model. In this regard, it also has been investigated the potential of aryl cationic porphycenes as photosensitizing drugs in APDT in vitro and in vivo, successfully inactivating different gram-positive and negative bacteria, and fungal cells.
Second, the kinetics of singlet oxygen (1O2) production and fate in E. coli have been investigated by means of an ultrasensitive near-infrared spectrometer with submicrosecond time resolution. The results allowed us to gain insight into the mechanism of APDT, i.e., the localization of the photosensitiser (PS) in the bacteria and the reactivity of 1O2. On one hand, the microenvironment of the PS changes when the distribution of the cationic charges changes. On the other hand, depending on the site of production, 1O2 reacts with the nearest microenvironment or is able to escape out of the cells.
Third, the ability of fluorescent proteins (GFPs), as genetically-encoded photosensitisers, to produce reactive oxygen species has been studied by means of fluorescent probes and time-resolved techniques. Thus, for the first time, the quantum yield of 1O2 production of some of the studied proteins has been calculated showing a value similar to that of the synthetic GFP chromophore.
Finally, the plasmonic effect of silver island films on 1O2 has been investigated using the near-infrared spectrometer, demonstrating a maximum enhancement of the 1O2 luminescence signal at 1270 nm ca. 30-fold in some cases.
Lau, Wai-lee Cherry, e 劉慧莉. "Outcomes of COPD patients receiving long term oxygen therapy: a retrospective cohort study". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3197014X.
Testo completoDing, Rui. "Enhanced Singlet Oxygen Production from Metal Nanoparticle Based Hybrid Photosensitizers". University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1447690607.
Testo completoShi, Shuning. "VEGF-A, VEGF-B and PIGF in mouse oxygen induced retinopathy /". St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17390.pdf.
Testo completoFranzen-Korzendorfer, Holly. "Effects of monochromatic infrared energy on transcutaneous oxygen measurements in diabetic subjects with a loss of protective sensation". Diss., NSUWorks, 2006. https://nsuworks.nova.edu/hpd_pt_stuetd/15.
Testo completoMoolman, Francis Sean. "Oxygen carriers for a novel bio-artificial liver support system". Pretoria : [s.n.], 2003. http://upetd.up.ac.za/thesis/available/etd-09092004-162043.
Testo completoTitle from opening screen (viewed Oct. 06, 2004). Summaries in English and Afrikaans. Includes bibliographical references (leaves 144-151).
Liebich, Ingrid. "Hyperbaric oxygen therapy for children with cerebral palsy : Jebsen-Taylor test of hand function". Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31117.
Testo completoAskie, Lisa. "A randomised controlled trial of oxygen therapy on growth and development of preterm infants". Connect to full text, 2003. http://hdl.handle.net/2123/599.
Testo completoIncludes tables and questionnaires. Title from title screen (viewed Apr. 28, 2008). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Centre for Perinatal Health Services Research, School of Public Health. Includes bibliography. Also available in print form.
Askie, Lisa Maree. "A randomised controlled trial of oxygen therapy on growth and development of preterm infants". Thesis, The University of Sydney, 2003. http://hdl.handle.net/2123/599.
Testo completoAskie, Lisa Maree. "A randomised controlled trial of oxygen therapy on growth and development of preterm infants". University of Sydney. Public Health, 2003. http://hdl.handle.net/2123/599.
Testo completoSmith, David L. "Nocturnal hypoxaemia in cystic fibrosis". Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296267.
Testo completoTroy, Lauren Kristie. "Supplemental Oxygen Therapy in Patients with Early Interstitial Lung Disease: Physiological Effects during Exercise and Sleep". Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16400.
Testo completoSmith, Cameron. "Intravenous Administration of Perfluorocarbon Emulsions as a Non-Recompression Therapy for Decompression Sickness". VCU Scholars Compass, 2008. http://scholarscompass.vcu.edu/etd/1555.
Testo completoDaulton, Donna Lynn. "Using Optimal Control Theory to Optimize the Use of Oxygen Therapy in Chronic Wound Healing". TopSCHOLAR®, 2013. http://digitalcommons.wku.edu/theses/1232.
Testo completoHoldsworth, Clark Thomas. "Vascular ATP-sensitive potassium channels impact spatial and temporal oxygen transport: implications for sulphonylurea therapy". Diss., Kansas State University, 2015. http://hdl.handle.net/2097/20562.
Testo completoDepartment of Anatomy and Physiology
Timothy I. Musch
Matching local muscle O[subscript]2-supply to O[subscript]2-demand during the prodigious exercise-induced metabolic challenge is achieved through coordinated mechanisms of vascular control. The unique sensitivity of ATP-sensitive potassium (K[subscript]ATP) channels to cell metabolism indicates the potential to match energetic demand to peripheral O[subscript]2 transport. The aim of this dissertation was to determine the magnitude and kinetics of the K[subscript]ATP channel contribution to vascular control during exercise in health and heart failure. It was hypothesized that K[subscript]ATP channel inhibition via glibenclamide would, in healthy rats, 1) reduce exercising skeletal muscle blood flow and vascular conductance 2) speed the fall of microvascular O[subscript]2 driving pressure (PO[subscript]2mv; set by the O[subscript]2 delivery-O[subscript]2 utilization ratio) during muscle contractions and 3) in heart failure rats, augment the PO[subscript]2mv undershoot and delay the time to reach the contracting steady-state. A total of 55 male Sprague-Dawley rats were used under control and glibenclamide conditions (5 mg kg[superscript]-1). Hindlimb muscle blood flow (radiolabelled microspheres) was determined at rest (n = 6) or during treadmill exercise (n = 6-8; 20, 40 and 60 m min[superscript]-1, 5% incline). Spinotrapezius muscle PO[subscript]2mv (phosphorescence quenching) was measured in 16 heart failure (coronary artery ligation) and 12 healthy rats and during 180 s of 1-Hz twitch contractions (~6 V). The major effects of glibenclamide were, in healthy rats, 1) a reduction in exercising hindlimb skeletal muscle blood flow with the greatest effect in predominantly oxidative muscle fiber types and at higher running speeds 2) an increased prevalence of the undershoot of PO[subscript]2mv steady-state and doubled time to reach the steady-state and 3) in heart failure rats, a reduced baseline PO[subscript]2mv, an augmented undershoot of the steady-state and time to reach steady-state and a reduction in the mean PO[subscript]2mv during contractions. These data suggest that the K[subscript]ATP channel contributes substantially to exercise-induced hyperemia and may contribute to the slowing of VO[subscript]2 kinetics given the spatial and temporal effects of glibenclamide. The K[subscript]ATP channel-mediated protection against a severe O[subscript]2-delivery to O[subscript]2-utilization mismatch at the onset of contractions raises serious concerns for sulphonylurea treatment in diabetes which is likely to cause perturbations of [metabolite] and compromise exercise tolerance.
Bauer, Timothy Alan. "Oxygen uptake kinetics in peripheral arterial disease". Diss., Manhattan, Kan. : Kansas State University, 2005. http://hdl.handle.net/2097/125.
Testo completoAtilgan, Serdar. "Water Soluble Distyryl-boradiazaindacenes As Efficient Photosensitizers For Photodynamic Therapy". Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607601/index.pdf.
Testo completoMarntell, Stina. "Sedation and dissociative anaesthesia in the horse : physiological and clinical aspects /". Uppsala : Dept. of Large Animal Clinical Sciences, Swedish Univ. of Agricultural Sciences, 2004. http://epsilon.slu.se/v169.pdf.
Testo completoYukruk, Funda. "Water Soluble Green Perylenediimide (pdi) Dyes As Potential Sensitizers For Photodynamic Therapy". Phd thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/3/12605693/index.pdf.
Testo completoan important parameter to be optimized for practical application as a novel photodynamic therapy agent was the excited dye toxicity to dark toxicity. Our results confirmed that these novel perylenediimides acted as sensitizers generating singlet oxygen and the initial in vitro biological experiments demonstrated their potential utility in photodynamic therapy.
Durand, Marcus L. "The evaluation of methods for the prospective patient safety hazard analysis of ward-based oxygen therapy". Thesis, Cranfield University, 2009. http://dspace.lib.cranfield.ac.uk/handle/1826/4480.
Testo completoO'Neill, Brenda. "The efficacy and use of ambulatory and short burst oxygen therapy in chronic obstructive pulmonary disease". Thesis, University of Ulster, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413826.
Testo completoDost, Zeynep. "Efficient Synthesis Of Novel Near Ir Emitting Distyrylboradiazaindacene Sensitizers For Photodynamic Therapy". Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/2/12607377/index.pdf.
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s therapeutic window. Therefore, there is a significant impetus to develop novel and better efficiency sensitizers for use in PDT. Boradiazaindacenes (BODIPY dyes or difluoroboradipyrrines) are well known fluorescent dyes. We discovered novel distyryl-derivatized boradiazaindacene dyes. These dyes have strong absorptions beyond 650nm. In order to transform these novel dyes into potential PDT reagents, bromine substituents were placed and then heavy atom effect was showed. We also demonstrated that on red-light excitation, singlet oxygen trap 1,3-diphenyl-iso-benzofuran is rapidly degraded.
Kong, Lingkun. "The expression of the VEGF gene in a mouse model of oxygen-induced retinopathy /". [St. Lucia, Qld.], 2000. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16968.pdf.
Testo completoJoyce, Lauren Elizabeth. "Ru(II), Os(II), and Rh2(II,II) Complexes as Potential Photodynamic Therapy Agents". The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1291176129.
Testo completoValentine, Ronan. "Biophysical aspects of photodynamic therapy". Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2471.
Testo completoAndrasik, Stephen James. "Singlet Oxygen Generation Using New Fluorene-Based Photosensitizers Under One- and Two-Photon Excitation". Doctoral diss., University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2210.
Testo completoPh.D.
Department of Chemistry
Sciences
Chemistry PhD