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Letteratura scientifica selezionata sul tema "Orlan – Exhibitions"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 19 febbraio 2022

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Articoli di riviste sul tema "Orlan – Exhibitions"

Chen, Ying, Ala Lisok, Samit Chatterjee, Bryan Wharram, Mrudula Pullambhatla, Yuchuan Wang, George Sgouros, Ronnie C. Mease e Martin G. Pomper. "[18F]Fluoroethyl Triazole Substituted PSMA Inhibitor Exhibiting Rapid Normal Organ Clearance". Bioconjugate Chemistry 27, n. 7 (24 giugno 2016): 1655–62. http://dx.doi.org/10.1021/acs.bioconjchem.6b00195.

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Helyer, Laura. "Memento and exhibition: consuming city, consuming character in Orhan Pamuk’s ‘The Museum of Innocence’". Heritage Turkey 2 (1 dicembre 2012): 39. http://dx.doi.org/10.18866/biaa2015.052.

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Harphoush, Seba, Guoqing Wu, Gao Qiuli, Margaret Zaitoun, Maissam Ghanem, Yonghui Shi e Guowei Le. "Thymoquinone ameliorates obesity-induced metabolic dysfunction, improves reproductive efficiency exhibiting a dose-organ relationship". Systems Biology in Reproductive Medicine 65, n. 5 (1 luglio 2019): 367–82. http://dx.doi.org/10.1080/19396368.2019.1626933.

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Correia, A. D., A. L. Pereira, M. H. Costa e F. Carrapiço. "Functional anatomy of the midgut gland of Gammarus locusta (Crustacea: Amphipoda)". Journal of the Marine Biological Association of the United Kingdom 82, n. 2 (aprile 2002): 201–4. http://dx.doi.org/10.1017/s0025315402005362.

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A description of the midgut gland of Gammarus locusta with the aim of using this organ as a complementary tool in ecotoxicological studies was made. The hepatopancreas is composed of two pairs of blind-ending tubular structures. The thickness and length of these tubules were ∼50 μm and 5 mm, respectively, in adult males (10–12 mm length). The distal part of each tubule is characterized by non-vacuolated E-cells typically exhibiting a relatively high nuclear to cytoplasmatic ratio. The epithelium of the remaining tubules is characterized by abundant columnar R- and F-cells, both ∼40 μm long. Large vacuolated B-cells (∼60 μm length) were very common along the midgut gland but seemed to increase in number in the proximal region of each tubule. An SEM examination revealed a delicate network of muscle fibres that limits the organ.

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Norman, MD. "Ameloctopus litoralis, gen. et sp. nov. (Cephalopoda : Octopodidae), a new shallow-water octopus from tropical Australian waters". Invertebrate Systematics 6, n. 3 (1992): 567. http://dx.doi.org/10.1071/it9920567.

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A new genus of octopus is described from northern Australian waters. Ameloctopus litoralis, gen. et sp. nov., is a shallow-water octopus characterised by the absence of an ink sac, vestigial funnel organ, terminal organ without a diverticulum, marked elongation of the arms and arm autotomy. It is found across northern Australia from southern Queensland to north-west Western Australia, primarily on coastal mudflats and intertidal reefs. This species occupies lairs in shallow and intertidal coastal habitats, feeding by extending arms from the safety of the lair or by foraging at night during low tides, over open sand, mud and rubble. A. litoralis lays large eggs, indicating that hatchlings are benthic and dispersal limited. Loss of the ink sac in a shallow-water octopod and the development of arm autotomy are discussed. Relationships with other octopod taxa exhibiting similar traits are examined.

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Ceesay, Abdoulie, Mariana Nor Shamsudin, Mohammed Aliyu-Paiko, Intan Safinar Ismail, Muhammad Farhan Nazarudin e Norfarrah Mohamed Alipiah. "Extraction and Characterization of Organ Components of the Malaysian Sea Cucumber Holothuria leucospilota Yielded Bioactives Exhibiting Diverse Properties". BioMed Research International 2019 (15 aprile 2019): 1–16. http://dx.doi.org/10.1155/2019/2640684.

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The aim of the present study was to extract and characterize bioactive components from separate body organs of Holothuria leucospilota. Preliminary qualitative assessment of the crude extracts was positive for phenols, terpenoids, carbohydrates, flavonoids, saponins, glycosides, cardiac glycosides, steroids, phlobatannins, and tannins in all body organs evaluated. Phenolics were the most abundant group of bioactives accounting for approximately 80%. The extraction solvent mixtures that yielded most compounds evaluated were methanol/acetone (3:1, v:v) and methanol/distilled water (3:1, v:v). In other analyses, GC-MS data revealed diverse metabolic and biologically active compounds, where those in high concentrations included 2-Pentanone, 4-hydroxy-4-methyl- among the ketones; phenol- 2,4-bis(1,1-dimethylethyl)-, a phenol group; and 2-Chlorooctane, a hydrocarbon. Among FA and their methyl/ethyl esters, n-hexadecanoic acid, 5,8,11,14-eicosatetraenoic acid ethyl ester (arachidonic acid), and 5,8,11,14,17-eicosapentaenoic acid methyl ester (EPA) were among the most abundant FAMEs accounting for approximately 50% of the subgroups measured. Data from GC-FID analysis revealed methyl laurate (C12:0), methyl myristate (C14:0), methyl palmitate (C16:0), and methyl stearate (18:0) methyl esters as the most abundant saturated FA, whereas cis-9-oleic methyl ester (C18:1) and methyl linoleate (C18:2) were found as the major monounsaturated FA and PUFA FAMEs, respectively, in the body wall of the species. Taken together, the extraction and characterization of different categories of metabolically and biologically active compounds in various organ extracts of H. leucospilota suggest that the species is potentially a rich source of cholesterol-lowering, antioxidant, antimicrobial, and anticancer agents. These substances are known to benefit human health and assist in disease prevention. These findings justify the use of sea cucumbers in traditional folklore medication and the current interest and attention focused on the species to mine for bioactives in new drugs research.

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Belsky, Daniel. "TESTING HEALTH DISPARITIES IN COGNITIVE AND BIOLOGICAL AGING IN OLDER ADULTS IN THE UNITED STATES". Innovation in Aging 3, Supplement_1 (novembre 2019): S427. http://dx.doi.org/10.1093/geroni/igz038.1595.

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Abstract We conducted analysis to test if health disparities in cognitive aging were parallel to or different from health disparities in patterns of aging in other systems in the body, and if race/ethnicity-related disparities could be accounted for by differences in socioeconomic circumstances across the life-course. We analyzed data from more than 10,000 adults participating in the US NHANES and US Health and Retirement Study. We measured cognitive aging using neuropsychological tests of processing speed and memory. We measured aging in other systems using composite indices of biological aging based on organ-system function tests and blood chemistries. We conducted analysis to (i) quantify and compare health disparities in cognitive aging and biological aging; (ii) test if individuals exhibiting accelerated cognitive aging were also exhibiting accelerated biological aging; and (iii) test if race/ethnic disparities in cognitive and biological aging could be explained by measured socioeconomic resource differences in childhood and later life.

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Yu, Haitao, Yasuo Nagafuchi e Keishi Fujio. "Clinical and Immunological Biomarkers for Systemic Lupus Erythematosus". Biomolecules 11, n. 7 (22 giugno 2021): 928. http://dx.doi.org/10.3390/biom11070928.

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Systemic lupus erythematosus (SLE) is characterized by immune system dysfunction and is clinically heterogeneous, exhibiting renal, dermatological, neuropsychiatric, and cardiovascular symptoms. Clinical and physiological assessment is usually inadequate for diagnosing and assessing pathophysiological processes in SLE. Clinical and immunological biomarkers could play a critical role in improving diagnosis, assessment, and ultimately, control of SLE. This article reviews clinical and immunological biomarkers that could diagnose and monitor disease activity in SLE, with and without organ-specific injury. In addition, novel SLE biomarkers that have been discovered through “omics” research are also reviewed.

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Haque, Shahara, Tarannum Morshed, Hasina Begum, Shahidul Islam, Kaniz Fatema, Afroza Begum e Muhammad Shoyab. "Tuberous Sclerosis Complex : A Case Report". Chattagram Maa-O-Shishu Hospital Medical College Journal 13, n. 3 (30 novembre 2014): 89–92. http://dx.doi.org/10.3329/cmoshmcj.v13i3.21044.

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The aim of this report is to present various clinical and radiological features of a young female patient with tuberous sclerosis who exhibited multiple hamartomas of various organ system. Tuberous sclerosis is a rare neurocuteneous syndrome exhibiting multiple hamartomatous proliferations that may involve multiple organ system such as brain, kidney, heart, lungs, eyes and skin. An 18 year old female patient presented with abdominal pain and swelling. Clinical examination of the patient revealed presence of facial angiofibromas and huge left flank mass. She also gave history of twin pregnancy with IUD. USG of abdomen showed bilateral gross angiomyolipoma with necrosis and haemorrhage in left kidney. CT and MRI of brain showed presence of multiple cortical tubers and calcified subependymal nodules. This case report is a good example of complex nature of tuberous sclerosis. The diagnosis and management of these patients depend on the presentation of the disease.DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i3.21044

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Camiolo, Giuseppina, Daniele Tibullo, Cesarina Giallongo, Alessandra Romano, Nunziatina Parrinello, Giuseppe Musumeci, Michelino Di Rosa et al. "α-Lipoic Acid Reduces Iron-induced Toxicity and Oxidative Stress in a Model of Iron Overload". International Journal of Molecular Sciences 20, n. 3 (31 gennaio 2019): 609. http://dx.doi.org/10.3390/ijms20030609.

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Iron toxicity is associated with organ injury and has been reported in various clinical conditions, such as hemochromatosis, thalassemia major, and myelodysplastic syndromes. Therefore, iron chelation therapy represents a pivotal therapy for these patients during their lifetime. The aim of the present study was to assess the iron chelating properties of α-lipoic acid (ALA) and how such an effect impacts on iron overload mediated toxicity. Human mesenchymal stem cells (HS-5) and animals (zebrafish, n = 10 for each group) were treated for 24 h with ferric ammonium citrate (FAC, 120 µg/mL) in the presence or absence of ALA (20 µg/mL). Oxidative stress was evaluated by reduced glutathione content, reactive oxygen species formation, mitochondrial dysfunction, and gene expression of heme oxygenase-1b and mitochondrial superoxide dismutase; organ injury, iron accumulation, and autophagy were measured by microscopical, cytofluorimetric analyses, and inductively coupled plasma‒optical mission Spectrometer (ICP-OES). Our results showed that FAC results in a significant increase of tissue iron accumulation, oxidative stress, and autophagy and such detrimental effects were reversed by ALA treatment. In conclusion, ALA possesses excellent iron chelating properties that may be exploited in a clinical setting for organ preservation, as well as exhibiting a good safety profile and low cost for the national health system.

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Tesi sul tema "Orlan – Exhibitions"

Kidd, Verity. "Perfection? - Recreating the human : an exhibition of works by Orlan, Patricia Piccinini, Margi Geerlinks and Jake and Dinos Chapman". University of Western Australia. School of Architecture, Landscape and Visual Arts, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0036.

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Perfection? - Recreating the Human is an exhibition of recent works of art by Orlan, Patricia Piccinini, Margi Geerlinks and Jake and Dinos Chapman. Each of the artists engages, in various ways, with issues relating to biotechnology and the body. The convergence of technology and the body arouses both utopian desires and dystopian nightmares; many of these desires and fears are prefigured in ancient myth and legend. The artists and artworks are therefore discussed with reference to reoccurring tropes from both ancient myth and science fiction.

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Libri sul tema "Orlan – Exhibitions"

Orlan. Orlan, 1964-1996. Roma: Diagonale, 1996.

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Orlan. Orlan. Paris: Flammarion, 2004.

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Orlan. Orlan, 1964-2001. Vitoria-Gasteiz: Artium, 2002.

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Orlan. Orlan: 1964.1996. Rome: Diagonale, 1996.

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Orlan. Orlan: Self-hybridations. Romainville: Al Dante, 1999.

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1934-, Vaneigem Raoul, Enthoven Raphaël e Abbaye royale et cistercienne de Maubuisson, a cura di. Orlan: Unions mixtes, mariages libres et noces barbares. Paris: Dilecta, 2010.

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Landier, Henri, e Bernard Baritaud. Henri Landier, Pierre Mac Orlan: Les confidences de l'ombre. [Saint-Cyr-sur-Morin]: Musée des pays de Seine-et-Marne, 2002.

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Orlan: Triomphe du baroque = triumph of the baroque. Marseille: Images En Manoeuvres, 2000.

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Nantes (France). Musée des beaux-arts, a cura di. Orlan: Un bœuf sur la langue. Lyon: Fage, 2011.

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Orlan. Orlan: Le récit = the narrative. Milano: Charta, 2007.

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Capitoli di libri sul tema "Orlan – Exhibitions"

Morris, Peter J. T. "‘An Effective Organ of Public Enlightenment’: The Role of Temporary Exhibitions in the Science Museum". In Science for the Nation, 212–49. London: Palgrave Macmillan UK, 2010. http://dx.doi.org/10.1057/9780230283145_11.

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Schadt, Eric E. "Network Methods for Elucidating the Complexity of Common Human Diseases". In Neurobiology of Mental Illness, a cura di Karl Deisseroth, 183–98. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199934959.003.0014.

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As big data comes to define the landscape in the life and biomedical sciences, carrying out successful research or providing the most appropriate diagnosis and treatment path for a given patient will more and more come to depend upon one’s ability to master the big data, to derive meaning and understanding from it. We can now score variations in DNA across whole genomes, RNA levels and alternative isoforms, metabolite levels, protein levels and protein state information, protein–protein interactions, and protein–DNA interactions, in a comprehensive fashion in entire populations of individuals. Interactions among these molecular entities define the complex web of biological processes that give rise to all higher order phenotypes, including disease. Most common forms of human disease such as schizophrenia, Alzheimer’s disease, and autism are not the result of single changes to single genes but rather emergent properties of the complex networks that define our systems at multiple scales (molecular, cellular, tissue, organ, organism, community). In order to elucidate the complexity of common human disease and other complex phenotypes, biological systems such as ourselves must be modeled as highly modular, fluid systems exhibiting a plasticity that allows them to adapt to a vast array of conditions. Leveraging the vast mountains of data to model biological systems in this way demands the development of analytical approaches that simultaneously integrate different dimensions of data. Here I motivate the need to take a more holistic approach to modeling biological systems and then detail different approaches that have been recently developed to carry out this type of modeling, from leveraging DNA variation as a systematic perturbation source to infer causal relationships among traits of interest, to the application of more advanced Bayesian network reconstruction algorithms to construct predictive network models of disease.

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Haroutounian, Joanne. "Talent as Giftedness". In Kindling the Spark. Oxford University Press, 2002. http://dx.doi.org/10.1093/oso/9780195129489.003.0012.

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Wolfgang Amadeus Mozart began composing at the age of four. He toured as a prodigy for three years before the age of ten, astounding audiences with his ability to perform on the harpsichord, voice, organ, and violin. He would compose on sight in different styles and on different instruments. He could “most accurately name from a distance any notes that may be sounded for him either singly or in chords, on the clavier or on every imaginable instrument, including bells, glasses, and clocks.” When his father was recovering from an illness, eight-year-old Wolfgang was not allowed to play the piano. He filled his time by composing his first symphony (K.16) for all instruments of the orchestra. When we hear the word “gifted” in connection with music, the musical prodigy immediately comes to mind. The arguments of recognizing talent through performance, creative endeavors, or music aptitude tests seem incidental in comparison to the possibilities and accomplishments of the musical prodigy. There is no question that these young musicians show incredible levels of musical talent, often exhibiting musical capabilities equal to those of a highly trained adult. Mozart remains the preeminent example of the prodigy, described by his father and teacher as a “God-given miracle,” knowing “in his eighth year what one would expect from a man of forty. Indeed, only he who sees him can believe it.” A prodigy is a child who displays extraordinary talent at an early age. Prodigies occur most often in the field of music, exceeding the total of all other fields combined. Musical prodigies show outstanding abilities at a younger age than other prodigies, with some as young as three or four years old. The field of chess is a distant second place in number, with prodigious achievement often seen at five or six years of age. Relatively few prodigies are identified in the natural sciences, philosophy, dance, or plastic arts. Even the field of mathematics, whose young calculating wonders gain media recognition, have few true prodigies capable of original mathematical reasoning prior to their teen years. The literature offers differing opinions concerning age and prodigious talent.

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Atti di convegni sul tema "Orlan – Exhibitions"

Al-Jighefee, Hadeel, Roba Abdin, Gheyath Khalid Nasrallah e Ola Aljamal. "Toxicity Evaluation of Stearamidopropyl Dimethylamine Surfactant on Embryonic development of Zebrafish". In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0194.

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Background: Surfactants best known for their use in the industry of detergents, household products, and cosmetics. Usually, the amount of released surfactants into the environment is diluted during secondary water treatment. However, there is always a risk of releasing untreated and polluted wastewater containing high amounts of surfactants without knowing the harmful effect on biotic and abiotic elements of the environment. SAPDMA is a surfactant that is used mostly in cosmetics, conditioning agents, and recently in corrosion inhibition. The classification of SAPDMA as a “safe” or “green” surfactant by different environment or chemical agencies is ambiguous, and the literature is lacking. Aim: The aim of this study is to evaluate the safety of SAPDMAusing the zebrafish embryo model. Methods: Zebrafish embryos were exposed to different concentrations of SAPDMA and the effect was assessed by different toxicity assays. This includes mortality/ survival assay to assess the median lethal dose (LC50) teratogenicity assay to assess the no observed effect concentration (NOEC); and organ specific toxicity assays including cardiotoxicity, neurotoxicity (using locomotion assay), and hemoglobin synthesis (using odianisidine staining). Results: Exposure of zebrafish embryos to SAPDMA caused mortality in a dose-dependent manner with a calculated LC50 of 2.3 mg/L. Thus, based on the LC50 value and according to the Fish and Wildlife Service Acute Toxicity Rating Scale, SAPDMA is classified as “moderately toxic”. The NOEC, the concentration that did not cause any significant teratogenicity, was 0.1mg/L. However, this concentration caused significant organ specific and cytotoxic effects, suggesting that harmless concentrations of SAPDMAare lower than 0.1 mg/L. Conclusion: Our data indicate that SAPDMA at very low concentrations causes adverse effects on zebrafish embryos. Thus, we recommend that the use of SAPDMA in industry should be re-evaluated and monitored by the environment and public health agencies.

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Al-Ansari, Dana E., Nura A. Mohamed, Isra Marei, Huseyin Yalcin e Haissam Abou-Saleh. "Assessment of Metal Organic Framework as Potential Drug Carriers in Cardiovascular Diseases". In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0127.

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Background: Cardiovascular diseases (CVDs) are considered the major cause of death worldwide. Therapeutic delivery to the cardiovascular system may play an important role in the successful treatment of a variety of CVDs, including atherosclerosis, ischemic-reperfusion injury, and microvascular diseases. Despite their clinical benefits, current therapeutic drugs are hindered by their short half-life and systemic side effects. This limitation could be overcome using controlled drug release with the potential for targeted drug delivery using a nanomedicine approach. In the current study, we have assessed the use of a highly porous nano-sized preparation of iron-based Metal-organic Framework (MOF) commonly referred to as MIL-89 as potential drug carriers in the cardiovascular system. Aims: To assess the effect of MOFs on the viability and cytotoxicity of human vascular cells and the cellular uptake in vitro, and the organ-system toxicity of MOF in vivo using the Zebrafish model. Methods: Human pulmonary endothelial cells (HPAECs) and pulmonary smooth muscle cells (HPASMCs) were treated with variable concentrations of MOFs. The viability, cytotoxicity and anti-inflammatory effects were measured using AlamarBlue, LDH assay and ELISA. The cellular uptake of MOFs were assessed using light, confocal, and transmission electron microscopes and EDS analysis. Moreover, Zebrafish embryos were cultured and treated with MOFs-nanoparticles at 0 hours post fertilization (hpf) followed by different organ-specific assays at 24, 48, and 72 hpf. Results: Although MOFs affect the viability at high concentrations, it does not cause any significant cytotoxicity on HPAECs and HPASMCs. Interestingly, MOFs were shown to have an anti-inflammatory effect. Microscopic images showed an increased (concentration-dependent) cellular uptake of MOFs and transfer to daughter cells in both cell types. Moreover, the in vivo study showed that high concentrations of MOFs delay zebrafish embryos hatching and cause heart deformation, which is currently investigated using cardiotoxicity markers. Conclusion: MOFs is a promising nanoparticle prototypes for drug delivery in the cardiovascular system with high cellular uptake and anti-inflammatory effects. Further investigations of MOFs, including diseased models and drug- loaded formulation is required.

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Aktas, MA, RK Kazmi, GR Randhawa e JB Brierley. "G361 Children, organ donation and islam: a report of a multi-disciplinary day". In Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference and exhibition, 13–15 May 2019, ICC, Birmingham, Paediatrics: pathways to a brighter future. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-rcpch.348.

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Mohbeddin, Abeer, Nawar Haj Ahmed e Layla Kamareddine. "The use of Drosophila Melanogaster as a Model Organism to study the effect of Innate Immunity on Metabolism". In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0224.

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Apart from its traditional role in disease control, recent body of evidence has implicated a role of the immune system in regulating metabolic homeostasis. Owing to the importance of this “immune-metabolic alignment” in dictating a state of health or disease, a proper mechanistic understanding of this alignment is crucial in opening up for promising therapeutic approaches against a broad range of chronic, metabolic, and inflammatory disorders like obesity, diabetes, and inflammatory bowel syndrome. In this project, we addressed the role of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) innate immune pathway in regulating different metabolic parameters using the Drosophila melanogaster (DM) fruit fly model organism. Mutant JAK/STAT pathway flies with a systemic knockdown of either Domeless (Dome) [domeG0282], the receptor that activates JAK/STAT signaling, or the signal-transducer and activator of transcription protein at 92E (Stat92E) [stat92EEY10528], were used. The results of the study revealed that blocking JAK/STAT signaling alters the metabolic profile of mutant flies. Both domeG0282 and stat92EEY10528 mutants had an increase in body weight, lipid deprivation from their fat body (lipid storage organ in flies), irregular accumulation of lipid droplets in the gut, systemic elevation of glucose and triglyceride levels, and differential down-regulation in the relative gene expression of different peptide hormones (Tachykinin, Allatostatin C, and Diuretic hormone 31) known to regulate metabolic homeostasis in flies. Because the JAK/STAT pathway is evolutionary conserved between invertebrates and vertebrates, our potential findings in the fruit fly serves as a platform for further immune-metabolic translational studies in more complex mammalian systems including humans.

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Soares, João S., Trung L. Le, Fotis Sotiropoulos e Michael S. Sacks. "Modeling the Role of Oscillatory Flow and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell Derived Heart Valve Tissue Engineering". In ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fmd2013-16165.

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Living tissue engineered heart valves (TEHV) may circumvent ongoing problems in pediatric valve replacements, offering optimum hemodynamic performance and the potential for growth, remodeling, and self-repair [1]. Although a myriad of external stimuli are available in current bioreactors (e.g. oscillatory flows, mechanical conditioning, etc.), there remain significant bioengineering challenges in determining and quantifying parameters that lead to optimal ECM development and structure for the long term goal of engineering TEHVs exhibiting tissue architecture functionality equivalent to native tissue. It has become axiomatic that in vitro mechanical conditioning promotes engineered tissue formation (Figure 1), either in organ-level bioreactors or in tissue-level bioreactors with idealized-geometry TE constructs. However, the underlying mechanisms remain largely unknown. Efforts to date have been largely empirical, and a two-pronged approach involving novel theoretical developments and close-looped designed experiments is necessary to reach a better mechanistic understanding of the cause-effect interplay between MSC proliferation and differentiation, newly synthetized ECM, and tissue formation, in response to the controllable conditions such as scaffold design, oxygen tension, nutrient availability, and mechanical environment during incubation. We thus evaluate the influence of exterior flow oscillatory shear stress and dynamic mechanical conditioning on the proliferative and synthetic behavior of MSCs by employing a novel theoretical framework for TE. We employ mixture theory to describe the evolution of the biochemical constituents of the TE construct and their intertwined biochemical reactions, evolving poroelastic models to evaluate the enhancement of nutrient transport occurring with dynamic mechanical deformations, and computational fluid dynamics (CFD) to assess the exterior flow boundary conditions developed in the flex-stretch-flow (FSF) bioreactor [4–6].

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Al-Asmar, Jawaher, Sara Rashwan e Layla Kamareddine. "The use of Drosophila Melanogaster as a Model Organism to study the effect of Bacterial Infection on Host Survival and Metabolism". In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0186.

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Enterobacteriaceae, a large family of facultative anaerobic bacteria, encloses a broad spectrum of bacterial species including Escherichia coli, Salmonella enterica, and Shigella sonnei, that produce enterotoxins and cause gastrointestinal tract diseases. While much is known about the regulation and function of enterotoxins within the intestine of the host; the lack of cheap, practical, and genetically tractable model organisms has restricted the investigation of others facets of this host-pathogen interaction. Our group, among others, has employed Drosophila melanogaster, as a model organism to shed more light on some aspects of host-pathogen interplays. In this project, we addressed the effect of Escherichia coli, Salmonella enterica, and Shigella sonnei infection on altering the metabolic homeostasis of the host. Drosophila melanogaster flies were orally infected with Escherichia coli, Salmonella enterica, or Shigella sonnei, a method that mimics the natural route used by enteric pathogens to gain access to the gastrointestinal tract in humans. The results of our study revealed that both Escherichia coli and Shigella sonnei pathogens were capable of colonizing the host gut, resulting in a reduction in the life span of the infected host. Escherichia coli and Shigella sonnei infected flies also exhibited altered metabolic profiles including lipid droplets deprivation from their fat body (normal lipid storage organ in flies), irregular accumulation of lipid droplets in their gut, and significant elevation of systemic glucose and triglyceride levels. These metabolic alterations could be mechanistically attributed to the differential down-regulation in the expression of metabolic peptide hormones (Allatostatin A, Diuretic hormone 31, and Tachykinin) detected in the gut of Escherichia coli and Shigella sonnei infected flies. Salmonella enterica; however, was unable to colonize the gut of the host; and therefore, Salmonella enterica infected flies exhibited a relatively normal metabolic status as that of non infected flies. Gaining a proper mechanistic understanding of infection-induced metabolic alterations helps in modulating the pathogenesis of gastrointestinal tract diseases in a host and opens up for promising therapeutic approaches for infection induced metabolic disorders

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