Tesi sul tema "Organisation spatiale du génome"
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Lapendry, Audrey. "Les biais de composition des gènes et de leurs produits établissent un lien entre l'organisation spatiale du génome et celle de la cellule". Electronic Thesis or Diss., Lyon, École normale supérieure, 2023. http://www.theses.fr/2023ENSL0109.
Testo completoGenes are not randomly distributed in the nucleus space, but are organized within more or less dynamical spatial clusters. This genome spatial organization plays a major role in gene expression regulation. Using different types of experimental data, it is shown that genes in spatial proximity to each other share the same nucleotide composition biases, which could in part explain the spatial genome self-organization. In addition, co-localized genes with similar biases have a higher probability of being co-regulated by the same transcription factors. They also produce RNAs that share the same nucleotide composition biases, that are co-regulated by the same RNA-binding proteins. Finally, mRNAs produced by genes that co-localize generate proteins that share the same amino acid composition biases. As a consequence, proteins produced by co-localized genes share the same physicochemical properties and have a higher probability of belonging to the same cellular sub-compartments and to have similar biological functions. Thus, by analyzing compositional biases, as a proxy of the physicochemical properties of genes and their products, it is highlighted a link between the spatial organization of genes in the nucleus and the spatial organization of their products (i.e. proteins) in the cell
Cournac, Axel. "Aspects temporel et spatial dans des systèmes de régulation génétique". Phd thesis, Université Paris-Diderot - Paris VII, 2009. http://tel.archives-ouvertes.fr/tel-00472602.
Testo completoTufaï, Muzafer. "Organisation sociale et spatiale en Macédoine yougoslave". Paris 5, 1985. http://www.theses.fr/1985PA05H020.
Testo completoLhuillier, Yves. "Architecture et programmation spatiale". Paris 11, 2005. http://www.theses.fr/2005PA112267.
Testo completoCurrent processor and multiprocessor architectures are almost all based on the Von Neumann paradigm. Based on this paradigm, one can build a general-purpose computer using very few transistors. The performance improvement of Von Neumann processors was mainly due to the increase in clock frequency of silicon technologies. Because clock frequency may no longer increase as quickly, there is a growing consensus on on-chip concurrent architectures being a major route for the efficient exploitation of an increasing number of transistors. In this thesis, we first introduce a new computing model, the “Blob Computing” defining both an architecture and a language, that is intrinsically designed to exploit space. Through this model, we also want to outline that revisiting some of the principles of today's computing paradigm has the potential of overcoming major limitations of current architectures. Finaly, we propose an implementation of the “Blob Computing” main ideas on more traditional architectures (multithreaded processors). Thanks to this implementation, we advocate that research efforts should further focus on striking the right balance between architecture, compiler and user effort. Especially, we show that letting the user reasonably effortlessly pass information on program parallel properties and making the architecture ``aware'' of this additional information is a promising path for futur processors scalability
Allardet-Servent, Annick. "Polymorphisme et organisation du génome à l'intérieur du genre Brucella". Montpellier 1, 1990. http://www.theses.fr/1990MON11304.
Testo completoKarayan-Tapon, Lucie. "Organisation du génome des bactéries appartenant au groupe alpha2 des proteobacteriaceae". Montpellier 1, 1992. http://www.theses.fr/1992MON11159.
Testo completoCanel, Annie. "Processus d'innovation technique, organisation de la firme et organisation spatiale Le cas de l'électronique". Phd thesis, Marne-la-vallée, ENPC, 1993. http://www.theses.fr/1993ENPC9312.
Testo completoCanel, Annie. "Processus d'innovation technique, organisation de la firme et organisation spatiale. Le cas de l'électronique". Phd thesis, Ecole Nationale des Ponts et Chaussées, 1993. http://tel.archives-ouvertes.fr/tel-00344621.
Testo completoDes problèmes se posent à deux niveaux: celui des stratégies d'organisation en matière de recherche et d'innovation et celui des moyens utilisés, notamment la gestion des ressources humaines et la gestion par projet, pour développer les interactions entre la R-D et les autres acteurs de la firme.
L'organisation spatiale des entreprises joue un rôle particulier dans les stratégies d'organisation; elle constitue à la fois une contrainte, par l'inertie des localisations, et un facteur de développement de nouvelles synergies, par la relocalisation des équipes de R-D ou la réorganisation spatiale des relations entre les acteurs du processus d'innovation.
Dupont, Céline. "Conformation de la chromatine et réorganisation spatiale du génome dans le noyau : relation de cause à effet et conséquences en clinique humaine". Paris 5, 2010. http://www.theses.fr/2010PA05T037.
Testo completoIn humans, nuclear architecture and chromatin organization during interphase play a crucial role in gene expression regulation. Within the nucleus, chromatin is organized nonrandomly in distinct chromosome territories optimizing the efficiency of transcriptional processes. Constitutive heterochromatin, which represents over 90% of our genome and whose role is largely unknown could be one of the main regulators of genome organization within the nucleus. Our goal was to study the effects of topographic changes of heterochromatin secondary to cohesin abnormalities (in Roberts syndrome) or methylation defect (in ICF syndrome) by 3D FISH and confocal microscopy. We have shown that the functional defect of cohesin secondary to ESCO2 mutations in Roberts syndrome causes a change in the architecture of pericentric heterochromatin associated with a repositioning in the nucleus. In ICF syndrome, DNA hypomethylation of constitutive heterochromatin seems also to modify nuclear architecture. These results shed new light on the regulation of 3D organization of the genome and further refine the hypothesis on gene expression control pathways in the pathophysiology of both disorders
Dauban, Lise. "Organisation du génome par le complexe cohésine chez la levure Saccharomyces cerevisiae". Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30100.
Testo completoCohesin is an evolutionary-conserved complex composed of a ring capable of DNA entrapment and of auxiliary proteins regulating its association with DNA. On the one hand, cohesin confers sister chromatid cohesion required for their proper segregation and on the other hand it establishes and maintains chromatin looping. Chromatin loops are crucial for assembly of topological domains, gene expression and genome stability. However, mechanisms driving their establishment remain to be elucidated. According to loop extrusion model, cohesin would capture small loops and enlarge them by extruding DNA throughout its ring. This model predicts that loop size would depend on both cohesin residence time on DNA and on its processivity. Deciphering cohesin regulation is thus fundamental to understand chromosome biology. In this study, we showed that mitotic chromosome arms of yeast Saccharomyces cerevisiae are organised in cohesin-dependent chromatin loops. We studied the role of cohesin regulatory subunits Pds5, Wpl1 and Eco1 on loop establishment. Our data show that Pds5 inhibits loop expansion via Wpl1 and Eco1. As previously described in mammals, Wpl1 counteracts loop expansion by dissociating cohesin from DNA. Our results suggest that Eco1 would inhibit cohesin translocation on DNA, required for loop expansion. We then studied how these proteins contribute to the organisation of the ribosomal DNA array (rDNA), a cohesin-rich, highly transcribed sequence segregated away from the rest of the genome. Our data point toward a central role for Pds5 in organising this genomic region, independently of Wpl1 and Eco1. To study in detail rDNA spatial organisation, we developed a dedicated image analysis to assess its organisation in three dimensions. We have unveiled an underlying organisation for rDNA, made by a succession of small domains spatially organised by cohesin. This study opens large perspectives towards a better understanding of cohesin regulation in genome organisation
Huet, Thomas. "Organisation spatiale et sériation des gravures piquetées du mont Bego". Phd thesis, Université de Nice Sophia-Antipolis, 2012. http://tel.archives-ouvertes.fr/tel-00712290.
Testo completoDaillant, Isabelle. "Sens dessus dessous : organisation sociale et spatiale des Chimane d’Amazonie bolivienne". Paris 10, 1994. http://www.theses.fr/1994PA100211.
Testo completoThis enquiry first sketches the historical background of the Chimane (as well as of their "relatives" and neighbors, the mostene) and sets out some of the fundamental of their identity (i. A. With reference to their relationships with their Indian and Bolivian neighbors). It then addresses of its two major themes: the kinship system. As is common in the amazon, the Chimane system is cognatic and Dravidian but it is in addition characterized by a singular distinctive mark: it is a global mode of functioning. The analysis seeks to show how this a-typical fea may result from the conjunction of different components of the system which combines very rigorous parts (concerning terminology and marriage) with others that are most flexible (in matters of residence and attitudes) but not less necessary. In addition to such theoretical issues, this pattern raises a problem of demography to which an answer may be provided by a historical hypothesis concerning the emergence of the present kinship network. The following section, dealing with religion and with an older, more formal, type of social organization, seeks both to give a fuller picture of the Chimane sociology (e. G. Intra-and inter-ethnic accusations of witchcraft, relationships with spirit «relatives") and to throw some light on a series of spatial representations (underpinning myths, views of after-death destiny, localization of spirits, rituals, former village topography). The last section deals specifically with spatial sues: noting the recurrence of the "reversal" theme, it also proposes an overall view of the morphology and orientation of the Chimane world. This is ordained by an internal-external opposition which can assume various concrete forms (concentric, west east, under over) and governs many representations. According to the spheres of reality to which they belong, these combine to form various pictures which while conforming to the same basic principles, remain relatively autonomous
Gicquel, Antoine. "Le système urbain pavillonnaire français : essai d'analyse structurelle d'une organisation spatiale". Tours, 2000. http://www.theses.fr/2000TOUR1504.
Testo completoPascarel, Devilder Marie-Claire. "Caractérisation, séquence nucléotidique et organisation du génome du virus 4 de Spiroplasma melliferum : spv4". Bordeaux 2, 1987. http://www.theses.fr/1987BOR22002.
Testo completoThiébaut, Michel. "INTERACTIONS FRONTO-PARIETALES: DYNAMIQUE ET ORGANISATION DES RESEAUX CEREBRAUX DE L'ATTENTION SPATIALE". Phd thesis, Université Pierre et Marie Curie - Paris VI, 2007. http://tel.archives-ouvertes.fr/tel-00803106.
Testo completoMartin, Jean-Yves. "Artisanat et tourisme en maine-et-loire. Approche economique et organisation spatiale". Angers, 1994. http://www.theses.fr/1994ANGE0020.
Testo completoKabatusuila, Panu-Mpanu. "Organisation spatiale, cadre de vie et crise de l'environnement à Kananga (Zaïre)". Bordeaux 3, 1994. http://www.theses.fr/1994BOR30026.
Testo completoKananga, the subject of this study is a town situated in the southern part of zaire. Serving as the metropolitan city of westen kasai, kananga has a population of 380. 000 inhabitants and lies on the latitudes 5o35' southwards and on the longitudes 22025' eastwards. The study aims to illustrate how human activities (for survival) in poverty stricten situations contribute to the degradation of the urban ecosytem. It is universally accepted that ecological balance results from equilibrum between the biotic, abiotic and human systems. The discruption of balanced relationship between these three systems can best explain the causes of the environmental problems encountered in kananga : massive soil erosions, pollutions, deforestation and the lack of sanitation etc. . . To clearly quality the effects of these problems, we carried out a systematic and integrated field survey. The analysis of this investigation helped us to come up some recommendations such and intensive community motivation and involvement as one of the stratigies by shich we can improve urban life
Dias, Miguel José. "Plasticité du génome de la bactérie Lactococcus lactis : domaines de contraintes révélés par inversions expérimentales". Toulouse 3, 2006. http://www.theses.fr/2006TOU30008.
Testo completoWe used artificial chromosome inversions to investigate the chromosomal constraints that preserve genome organization Lactococcus lactis. Chromosomal inversions are the most appropriate rearrangement for the experimental analysis of genome organization because they disturb the normal order of sequences on the chromosome without affecting overall genetic content. Twenty large inversions, 80-1260 kb in length, were constructed using the site-specific Cre-loxP recombination system. These inversions were all mechanistically feasible and fell into various classes according to stability and effect on cell fitness. The location of detrimental inversions allowed identification of two constrained chromosomal regions : a large domain covering one fifth of the genome that encompasses the origin of replication (Ori domain) and a smaller domain, covering approximately 200 kb, located at the opposite of the chromosome (Ter domain)
Baudrimont, Marie. "Analyse quantitative de la morphologie neuronale : facteurs influençant l'organisation spatiale de l'arborisation dendritique". Aix-Marseille 2, 1987. http://www.theses.fr/1987AIX21916.
Testo completoLestrade, Marc. "Système d'information et implantation spatiale des grandes entreprises". Paris 4, 1999. http://www.theses.fr/1998PA040326.
Testo completoGodwin, Matthew. "The Skylark rocket : British space science and the European space research organisation, 1957-1972 /". Paris : Beauchesne, 2007. http://catalogue.bnf.fr/ark:/12148/cb411905977.
Testo completoThiebaut, de Schotten Michel. "Interactions fronto-pariétales : dynamique et organisation des réseaux cérébraux de l'attention". Paris 6, 2007. http://www.theses.fr/2007PA066719.
Testo completoSpatial attention refers to a family of cognitive processes which allow us to interact efficiently with our environment, by selecting relevant stimuli and inhibiting distractors. Unilateral spatial neglect (USN) is a dramatic neurological condition resulting from damage to the right hemipshere of the human brain. USN is mainly characterized by a severe lack of attention for left, contralesional stimuli. This thesis uses USN to demonstrate that a normal distribution of spatial attention needs unimpaired pathways linking the parietal to the frontal lobe. The second part of this thesis deals with the connectional anatomy of long-range brain pathways, the relevance of the study of these pathways to cognitive neuroscience (hodological approach), and the consequences of white-matter disconnections in neurological syndromes
Bodet, Jean-Marie. "Etude expérimentale de phénomènes d'auto-organisation spatiale dans les systèmes chimiques hors d'équilibre". Bordeaux 1, 1986. http://www.theses.fr/1986BOR10640.
Testo completoBodet, Jean-Marie. "Etude expérimentale de phénomènes d'auto-organisation spatiale dans les systèmes chimiques hors d'équilibre". Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb375960982.
Testo completoRamasinjatovo, Nirinjaka. "Organisation et perception de l'espace en Imerina, Madagascar". Paris 5, 2008. http://www.theses.fr/2008PA05H041.
Testo completoThis dissertation's objective is to analyze the current influence of spatial markers of Merina's identity and its evolution in the space organization, perception and also the social relationships that are related to these latters. The spatial markers assessed here are the irrigated rice culture, the tombs and the houses. We highlight how the evolution of the socioeconomic context determines the level and the nature of the markers'influence. Moreover, this dissertation offers a cultural perspective to illustrate the relationships and interdependencies between the population and its environment
Terrone, Sophie. "Connexion entre organisation 3D du génome et épissage alternatif médiée par les hélicases DDX5 et DDX17". Thesis, Lyon, 2019. https://n2t.net/ark:/47881/m6n015wq.
Testo completoAlternative splicing is the mechanism that allows the production of several mRNA isoforms from the same gene, and that concerns the majority of human genes. As it occurs during transcription, both processes are co-regulated. Several recent studies have proposed that the three-dimensional organization of the genome, which regulates transcription, could also have an impact on splicing. DDX5 and DDX17 are two RNA helicases involved in several steps of RNA biogenesis and processing, including transcription and splicing. Notably, previous studies from our lab have shown they are downregulated during cellular differentiation, which contributes to establish specific splicing programs. Moreover, DDX5/17 interact with CTCF and Cohesin that are key regulators of chromatin topology and looping. This suggests a role for DDX5/17 in genome topology, and could suggest their involvement in the cross-talk between 3D organization and splicing. In order to address this question, we first assessed the impact of DDX5/17 on splicing by RNA-Seq and tested the contribution of CTCF and Cohesin on DDX5/17-dependant exon inclusion. We observed that the co-depletion of CTCF and Cohesin with DDX5/17 increases the effect of the helicases on the inclusion of some exons. Moreover, our results indicate for the first time that depletion of DDX5/17 deregulates transcriptional termination of many genes. Finally, we selected two exons regulated by both DDX5/17 and CTCF and investigated the three-dimensional organization of their associated genes by Chromosome Conformation Capture (3C) assays. The first exon is located within the NCS1 gene while the second exon has a promoter-proximal position in the PRMT2 gene. Our 3C experiments indicate the presence of a chromatin loop between the NCS1 promoter and its internal DDX5/17- and CTCF-regulated exon. Moreover, our results reveal a physical proximity between the promoter and the terminator region of both genes, and a deregulation of this specific configuration upon DDX5/17 depletion, which could possibly lead to transcriptional readthrough. Finally, stabilizing the promoter-terminator loop using a dCas9-based approach altered the inclusion of the PRMT2 promoter-proximal exon. Altogether, our results support the hypothesis of a mechanistical link between the 3D organization of genes and the regulation of alternative splicing and transcription fidelity
Trichet, Valérie. "Étude structurale et organisation des gènes vitellogénine dans le génome de la truite arc en ciel". Rennes 1, 1996. http://www.theses.fr/1996REN10090.
Testo completoLabbé, Jessy. "Contribution à l'étude de la structure et du polymorphisme du génome du basidiomycète ectomycorhizien "Laccaria bicolor" (Maire) Orton et identification de QTLs de mycorhization chez les peupliers, "Populus trichocarpa Torr. & A. Gray ex Hook. et "Populus deltoides (Bartr.) Marsh". Thesis, Nancy 1, 2009. http://www.theses.fr/2009NAN10079/document.
Testo completoThe mycorrhizal symbioses between fungi and roots concern 95 % of the plant species. Social trees of boreal and temperate forests form a particular type of root association with fungi: the ectomycorrhizal symbiosis. Ectomycorrhizas play a major role in tree hydromineral nutrition, nutrient cycles and primary production. However, their complexity have so far prevented from deciphering their precise function and role. The recent availability of the genome of the ectomycorrhizal fungus Laccaria bicolor and that of the host-tree Populus trichocarpa provides an unprecedented opportunity to decipher the key components of development and functioning of this symbiosis. The aims of this study were to participate to the characterization and deciphering of the genome of L. bicolor, and to determine the genes involved in the formation of ectomycorrhizas in both partners. Firstly, in order to facilitate the assembly of the genomic sequence of L. bicolor, we have identified the repeated sequences and generated a genetic map. On the 60 Mb of this genome, 8 % are microsatellite sequences and 24 % transposable elements. A genetic map was built from 111 monokaryons issued from L. bicolor S238N. This map includes 326 markers (8 RAPD, 243 AFLP, 59 SSR and 14 SNP) distributed on 10 linkage groups anchored onto the genomic sequence of L. bicolor. Secondly, we have identified the genes involved in the establishment of ectomycorrhizas in poplar by combining QTL detection and DNA microarrays. We targeted 81 genes which can be involved in the establishment and/or the functioning of the symbiosis
Maunier-Sifre, Laurence. "Organisation spatiale du tissu conjonctif intramusculaire : relation avec la texture de la viande bovine". Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2005. http://tel.archives-ouvertes.fr/tel-00668883.
Testo completoAlberton, Lorenzo. "Organisation spatiale des activités techniques sur un campement du prédorsétien tardif (2900-2500 AA)". Thesis, Université Laval, 2006. http://www.theses.ulaval.ca/2006/23989/23989.pdf.
Testo completoLECLERC, JACQUES. "Organisation spatiale d'un assemblage d'araignees et strategies d'exploitation des ressources : approche experimentale et modelisation". Paris 6, 1990. http://www.theses.fr/1990PA066201.
Testo completoCavey, Matthieu. "Organisation spatiale de l'adhérence intercellulaire par le cytosquelette d'actine dans l'épithélium embryonnaire de drosophile". Aix-Marseille 2, 2008. http://theses.univ-amu.fr.lama.univ-amu.fr/2008AIX22092pdf.
Testo completoIntercellular adhesion, crucial for tissue cohesion, is maintained by E-Cadherin (E-Cad) transmembrane proteins which are dynamically linked to the actin cytoskeleton via β- and α-Catenin. To understand how this dynamic interaction stabilizes adhesion and how E-Cad molecules are distributed at the cell surface, i have used drosophila embryonic epithelial cells during my phD. My work reveals two levels of control of adhesion by actin. One population of actin filaments with a slow turnover maintains locally E-Card molecules in stable aggregates. Another population of filaments, with rapid turnover, controls the localization of these aggregates by immobilizing them by an anchoring mechanism which involves α-Catenin. This work identifies the main function of α-Catenin in adhesion control and demonstrates that adhesion is spacially organized at the cell surface
Durand, Eric. "Modèles statistiques pour la structure génétique des populations : organisation spatiale et liens de parentés". Grenoble INPG, 2009. http://www.theses.fr/2009INPG0064.
Testo completoGenetic structure arises when genetically differentiated groups are present among a set of organisms. The knowledge of genetic structure is of first importance in many domains, such as the detection of genes associated with diseases or in conservation genetic. We developed two very different statistical methods to analyze the genetic structure of populations, which is generally hidden. The first method assumes that we have genotyped multilocus markers for a set of georeferenced individuals. We built an MCMC algorithms to infer the genetic structure taking advantage of the spatial information. The second method only relies on the census number of organisms in a population. We developed a coalescent model of animal group patterns which assumes that individuals tend to group with their closest relatives
Chaplot, Vincent. "Organisation spatiale des sols hydromorphes de fonds de vallee. Modelisation predictive de leur distribution". Rennes, Agrocampus Ouest, 1998. http://www.theses.fr/1998NSARD028.
Testo completoGuevara, Garcia Rosario Amaris. "Organisation spatiale et ségrégation des récepteurs BMP2 dans les sites d'adhésion impliquant l'intégrine β3". Thesis, Université Grenoble Alpes, 2020. https://thares.univ-grenoble-alpes.fr/2020GRALV039.pdf.
Testo completoHow cells integrate biochemical and physical input from the extracellular matrix to achievespecific cell differentiation through adhesive receptor signaling is a big challenge in cellbiology. BMP2 is a crucial molecule for normal bone development in vertebrates andinduces osteoblastic differentiation of pluripotent mesenchymal cells likely troughcoordination with matrix elements such as fibronectin. The host lab has previously shownthat BMP receptors and β3 integrin work together to control Smad signaling and tensionalhomeostasis (Fourel, 2016), thereby coupling cell adhesion and fate commitment -twofundamental aspects of developmental biology and regenerative medicine. However, stillrequire to indentify whether their spatial arrangement affects the cellular response toreceptor signaling. Whether dynamics between integrin and BMP receptors is controlled inspace and time to guide pivotal intracellular processes remains to be elucidated.My work during this Ph.D. consisted of investigating the distribution of BMP2 receptors(ALK3 and BMPRII) and β3 integrin at the cell surface and the impact of their physicalproximity on cell behavior by combining live imaging, fluorescent recovery afterphotobleaching (FRAP), biomimetic substrates, and an optogenetic approach.My results showed that BMP receptors (BMPR) are discretely organized into segregatedspatial domains at the cell surface. I have shown that ALK3 is enriched at β3-integrin focaladhesions after BMP2 stimulation. Unlike ALK3, BMPRII is often excluded from these sitesand never enriched. Furthermore, the use of specific matrix protein reveals that therecruitment of ALK3 in focal adhesion is visible when β3 integrin is prone to form focaladhesions upon its engagement. The activated form of ALK3 is able to be localized inadhesion sites independently on BMP2. These results suggested that ALK3 organization atadhesion sites is dependent on integrin activity and ALK3 activation by BMP2 stimulation.FRAP experiments support the BMPR segregation model showing a distinct pattern oflateral movement of ALK3 and BMPRII upon BMP2 treatment through trapping of ALK3within focal adhesions.For a reversible and light-controlled interaction between BMPR and β3 integrin in space andtime, an optogenetic approach is based on the Venus-iLID (improved Light Inducer Dimer)system (Guntas, 2016) has been developed. These approaches mimic BMP2 stimulation bytargeting ALK3, but not BMPRII, into β3 integrin containing focal adhesions. Additionally,the optogenetic approach allows us to apply or withdraw the light signal to induce theproximity between ALK3 and β3 integrin offering the opportunity to induce rapid and localsignal activation. My results show that this light-induced proximity of ALK3 and β3 integrinis sufficient to induce cell spreading on a soft substrate independently on matrix-boundBMP2. Moreover, the targeting of ALK3 into β3 integrin containing focal adhesion uponBMP2 treatment is responsible for cell migration induced by matrix-bound BMP2.These results show that the cooperation between β3 integrin and ALK3 converges alreadyat the cell surface upon BMP2 stimulation. These data demonstrate that the microdomainclustering of ALK3 with β3 integrins is highly regulated by both BMP2 stimulation and β3integrin engagement, indicating that the spatial control of ALK3 might have specificfunctional implications for mechanotransduction or BMP signaling.From a broader perspective, this coupling between Integrins and BMP signaling pathwaysis of great relevance in developmental processes and regenerative medicine, where cellrecruitment is a prerequisite to cell differentiation to form a specific organ or repairdamaged tissue. Identification of signaling will provide new therapeutic strategies foroptimizing bone repair and regeneration
Stahl, Philippe. "Le Chat forestier d'Europe, Felis silvestris, Schreber 1777 exploitation des ressources et organisation spatiale /". Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37601337s.
Testo completoMaunier-Sifre, Laurence Culioli Joseph. "Organisation spatiale du tissu conjonctif intramusculaire Relation avec la texture de la viande bovine /". Clermont-Ferrand : Université Blaise Pascal, Clermont-Ferrand 2, 2009. http://195.221.120.247/simclient/consultation/binaries/stream.asp?INSTANCE=UCFRSIM&eidmpa=DOCUMENTS_THESES_110.
Testo completoMoindrot, Benoît. "Organisation de la chromatine et son lien avec la réplication de l'ADN". Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2012. http://tel.archives-ouvertes.fr/tel-00733254.
Testo completoDordet-Frisoni, Emilie. "Staphylococcus xylosus : cartographie du génome et diversité génétique". Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2007. http://tel.archives-ouvertes.fr/tel-00718141.
Testo completoDordet-Frisoni, Emilie. "Staphylococcus xylosus : cartographie du génome et diversité génétique". Phd thesis, Clermont-Ferrand 2, 2007. http://www.theses.fr/2007CLF21760.
Testo completoRodriguez, Mathieu. "Évolution et organisation spatiale de la dynamique vibratoire des arbres au cours de leur développement". Phd thesis, Ecole Polytechnique X, 2009. http://pastel.archives-ouvertes.fr/pastel-00005729.
Testo completoVIAUD, Valérie. "Organisation spatiale des paysages bocagers et flux d'eau et de nutriments. Approche empirique et modélisations". Phd thesis, Agrocampus - Ecole nationale supérieure d'agronomie de renneS, 2004. http://tel.archives-ouvertes.fr/tel-00007460.
Testo completoLe premier objectif de cette thèse est d'aborder l'impact du bocage sur les flux d'eau et de nutriments à l'échelle du bassin versant, compatible avec la gestion de la ressource en eau. Le second objectif est d'articuler les connaissances sur les fonctions tampons des haies avec les connaissances sur l'organisation et l'évolution des paysages sous l'effet de dynamiques agricoles. Trois axes ont été développés : un axe conceptuel pour définir le rôle tampon des paysages, un axe empirique de comparaison du rôle tampon à l'exutoire de cinq bassins versants et un axe de modélisation. Ce
dernier comprend d'une part l'intégration des résultats locaux sur le fonctionnement hydrique des haies (évapotranspiration) dans un modèle hydrologique spatialisé et d'autre part une démarche de modélisation de paysages à partir de règles de fonctionnement (allocation des usages) et d'évolution des exploitations agricoles (agrandissement, changement de système de production), couplée à deux modèles de description de l'organisation fonctionnelle des réseaux de haies, l'un pour les transferts de surface, l'autre pour les transferts de subsurface.
Une analyse bibliographique critique du concept de rôle tampon et de sa mesure à des échelles spatiales larges a été réalisée. Elle a débouché sur une typologie des effets tampons des structures paysagères, basée sur la prise en compte du temps, et sur la définition d'un effet tampon des paysages intégrant l'effet des structures paysagères et du milieu physique. L'étude empirique montre un gradient de rôle tampon qui va dans le sens du gradient de densité de bocage entre les bassins. Elle fait ressortir la co-variation des types de géomorphologie, des types de système de production, des types de parcellaire, et des types de bocages, dans les paysages. La modélisation hydrologique montre spécifiquement le rôle hydrologique des haies à l'échelle annuelle, plus marqué les années sèches.
Dans la modélisation de paysages, le rôle de l'exploitation agricole dans l'organisation spatiale des usages et de leur évolution est pris en compte explicitement. Elle montre qu'une même évolution des exploitations se traduit par une évolution variable de l'effet tampon à l'échelle des bassins versants.
Le rôle tampon sur les transferts de subsurface apparaît plus stable et plus résilient que le rôle tampon sur les transferts de surface, très dépendant de la continuité du réseau de haies..
Viaud, Valérie. "Organisation spatiale des paysages bocagers et flux d'eau et de nutriments : Approche empirique et modélisations". Rennes, Agrocampus Ouest, 2004. http://www.theses.fr/2004NSARD041.
Testo completoRoche, Philip. "Structuration de la végétation et organisation du paysage en Provence calcaire : approche spatiale et hiérarchique". Aix-Marseille 1, 1994. http://www.theses.fr/1994AIX11008.
Testo completoPerrin, Catherine. "Organisation socio-spatiale et distribution des activités chez la marmotte alpine (Marmota marmota Linné 1758)". Paris 7, 1993. http://www.theses.fr/1993PA077087.
Testo completoViaud, Valérie. "Organisation spatiale des paysages bocagers et flux d'eau et de nutriments : approche empirique et modélisations /". Rennes : Éd. de Géosciences Rennes, 2004. http://catalogue.bnf.fr/ark:/12148/cb39955689n.
Testo completoGaussier, Nathalie. "Environnement et organisation spatiale : un modèle statique et dynamique d'étude de la localisation des décharges". Aix-Marseille 3, 1998. http://www.theses.fr/1998AIX32045.
Testo completoSINCE 1990'S, OBNOXIOUS GOODS LOCATION IS UNDERGOING PROFOUND CHANGES. AN ORGANIZATIONAL LOGIC BASED ON THE COMBINATION OF RECYCLING FACILITIES AND INCINERATORS MARKS THE END THE STORAGE LOGIC. THESE OBJECTIVES MIGHT RADICALLY TRANSFORM THE SPATIAL ORGANIZATION. THE STORAGE LOGIC THAT PREVAILED, LOCALIZED THE GARBAGE DUMPS AS FAR AS POSSIBLE FROM THE INHABITANTS IN THE AREAS OF THE JURISDICTION OF THE TOWNS. THIS LOGIC SHOULD BE REPLACED BY AN ORGANIZATIONAL ONE THAT IS LOOKING FOR SCALES ECONOMIES IN THE VICINITY OF THE TOWNS IN ORDER TO MANAGE NETWORK AREA AND TO HAVE THE ADVANTAGE OF AGGLOMERATION ECONOMIES. NEVERTHELESS, THE LOCAL AUTHORITIES FACE THE VIRULENCE OF THE NIMBY SYNDROME (NEVER IN MY BACK YARD) AND THE UNCERTAINTY ABOUT THE DURATION OF THE TREATMENT MEANS. THEY BEHAVE IN AMBIVALENT WAYS. THE INERTIA OF THE PREVIOUS LOGIC IS AN EXAMPLE. PREVIOUS EXPERIENCE IN LANDFILLS SITE LOCATION IS INSTRUCTIVE. OUR THESIS IS BASED ON 1980S DATA IN PROVENCE-ALPES-COTE D'AZUR AREA. TWO LEVELS OF OUR WORK HANG TOGETHER. WE HAVE BUILT A PROBABILISTIC MODEL BASED ON THE COMPLEXE BEHAVIOUR OF A TOWN IN ITS GARBAGE DUMP LOCATION. THIS APPROACH HAS BEEN ENLARGED TO THE CASE OF SEVERAL TOWNS. OUR STATIC MODEL HAS AN INTERESTING FORECASTING ASPECT. OUR DYNAMIC MODEL EXPLAINS, without BEING A DEMONSTRATION, SOME PROCESS THAT COULD SUPPORT THE COMPLEX CONFIGURATIONS WE OBSERVED IN THE PROBABILISTIC APPROACH. THE ARRANGEMENT OF THE STATIC AND DYNAMIC APPROACHES IS FRUITFUL. IT IS A WAY TO PROGRESS WITH THE UNDERSTANDING OF THE SPATIAL MICROECONOMIC BEHAVIOURS
Le, Bourgeois Pascal. "Structure et organisation du chromosome de Lactococcus lactis : [thèse en partie soutenue sur un ensemble de travaux]". Toulouse 3, 1993. http://www.theses.fr/1993TOU30095.
Testo completoWierinckx, Anne. "Les gènes de fucosyltransférases de Bos Taurus "Organisation et expression d'un gène (futb) d'alpha 3-fucosyltransférase"". Limoges, 1999. http://www.theses.fr/1999LIMO0004.
Testo completoRobin, Guillaume. "L'art pariétal des tombes à couloir néolithiques autour de la Mer d'Irlande : iconographie et organisation spatiale". Phd thesis, Université de Nantes, 2008. http://tel.archives-ouvertes.fr/tel-00360165.
Testo completoexclusivement de signes géométriques, considérés généralement comme abstraits et non structurés.
Une analyse spatiale révèle au contraire une réelle organisation des signes. Cette analyse, menée sur plus
de 630 dalles gravées, met en avant un grand nombre de récurrences dans l'association des signes, dans
leur positionnement sur les pierres ainsi que dans leur emplacement dans l'architecture complexe des
tombeaux. Il est ainsi possible de définir une véritable « syntaxe » régissant l'agencement des signes à
différentes échelles de l'espace. Cette syntaxe permet par ailleurs de retrouver la position d'origine de
dalles gravées en réemploi dont les gravures, en position secondaire, sont « désorganisées ». Enfin, une
étude de l'organisation des éléments architecturaux et des dépôts funéraires montrent que ceux-ci
forment avec l'art pariétal un seul et même modèle symbolique de représentation spatiale.