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Articoli di riviste sul tema "Oncogeriatrics"

Autore: Grafiati

Pubblicato: 16 novembre 2024

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1

Monfardini, Silvio, Francesco Perrone e Lodovico Balducci. "Pitfalls in Oncogeriatrics". Cancers 15, n. 11 (25 maggio 2023): 2910. http://dx.doi.org/10.3390/cancers15112910.

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An oncogeriatric interdisciplinary activity exists only in a minority of high-income countries, and it is almost absent in those with lower incomes. Considering topics, sessions, and tracks in the main meetings and conferences of the major Oncological Societies in Europe and worldwide, the USA excluded, little attention has thus far been paid to the problem of cancer in the elderly. Again, with the exception of the USA, the major cooperative groups, for example, the EORTC in Europe, have only dedicated marginal attention to the research of cancer in the elderly. Despite major shortcomings, professionals interested in geriatric oncology have taken a number of important initiatives to highlight the benefits of this particular activity, including the organization of an international society (Société Internationale de Oncogeriatrie, or SIOG). In spite of these efforts, the authors believe that the management of cancer in the older population is still encountering several important and generalized pitfalls. The main obstacle is the grossly inadequate number of geriatricians and clinical oncologists necessary to an integrated care of the ever-expanding aging population, but other hurdles have been reported. Additionally, the prejudice of ageism can lead to missing potential resources for the development of a generalized oncogeriatric approach.

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Rey, Jean-Baptiste, Damien Parent e Stephane Perin. "Oncogeriatrics joint consultations: When pharmacists improve patients' management together with oncogeriatrics physician." Journal of Clinical Oncology 32, n. 31_suppl (1 novembre 2014): 79. http://dx.doi.org/10.1200/jco.2014.32.31_suppl.79.

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79 Background: Elderly patients often have several diseases and therefore polymedicated. Comorbidities and treatments may interfere with management of oncological patients. Methods: The objectives of this project are 1) to ensure a proper understanding of patients regarding their treatment, 2) to perform a pharmaceutical analysis of patients’ prescription, 3) to propose changes to the patients’ doctors (general practitioners and physicians of the Institute) to prevent and reduce adverse drug events. The project combines medical and pharmaceutical expertise around the patient to optimize their care coordinated with the action of a "disease professional” and a "drug professional " with a particularly vulnerable population. Results: Since the project began, more than 100 patients benefited from these joint consultations, thus establishing a network between the Institute and the general practionners supporting our patients. Optimization of drug treatment and reduction of iatrogenic events avoids the complications and hospitalizations extensions and / or re-hospitalization. The pharmaceutical intervention documented in the medical records of patients (explaining terms of the intervention) and the transmission of the report to "pharmaceutical consultation" to physician 1) improves the management of patients (reduction potential iatrogenic events – e.g. risk of falling by orthostatic hypotension) and 2) allows the referring physician to optimize patient care. Conclusions: Launched in 2010, the project entered its fourth year of existence and continues.

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Cohen, Q., P. Bocquet, A. Sebaux, J. L. Novella e A. A. Zulfiqar. "P-165: Oncogeriatrics: multidisciplinary management". European Geriatric Medicine 6 (settembre 2015): S76. http://dx.doi.org/10.1016/s1878-7649(15)30265-5.

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Carvalho, Dayara de Nazaré Rosa de, Viviane Ferraz Ferreira de Aguiar, Lorena Nayara Alves Neves, Celice Ruanda Oliveira Sobrinho, Dandara de Fátima Ribeiro Bendelaque, Rafael Everton Assunção Ribeiro da Costa, Djenanne Simonsen Augusto de Carvalho Caetano et al. "Clinical-epidemiological profile of the oncogeriatric patient served in high complexity public hospitals in the State of Pará in the historical series 2014-2018". Research, Society and Development 9, n. 9 (15 agosto 2020): e189996821. http://dx.doi.org/10.33448/rsd-v9i9.6821.

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Introduction: Cancer is classified as a set of cells that have a disordered growth and without specific functions, in which they affect the systems, being that the main population affected is the elderly, due to the associated risk factors, being highlighted the process of cell aging. Objective: to trace the clinical-epidemiological profile of the oncogeriatric patient seen in public hospitals of high complexity in the State of Pará, in the 2014-2018 historical series. Methodology: This is an epidemiological, descriptive retrospective study with a quantitative approach. The study was carried out in the month of June 2020 with information from secondary data, coming from the Hospital Cancer Registry Computerization System for oncogeriatric patients seen in high complexity hospitals in the state of Pará in the period from 2014 to 2018. Results: if the total of 8,184 oncogeriatrics patients seen in hospitals in Pará and the distribution of sociodemographic data found the predominance of the male population, in the age group between 60 and 69 years old, brown race, most have only incomplete fundamental level. Conclusion: It is necessary for professionals to carry out health education practices for this public, in order to raise awareness and encourage self-care, so that these rates are overcome and they can age with a better quality of life.

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Kenig, Jakub. "Oncogeriatrics (part 8.). Frailty screening tools". Nowotwory. Journal of Oncology 70, n. 5 (5 ottobre 2020): 184–86. http://dx.doi.org/10.5603/njo.a2020.0039.

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Kenig, Jakub. "Oncogeriatrics (part 2.). Normal and pathological ageing". Nowotwory. Journal of Oncology 69, n. 3-4 (31 ottobre 2019): 146–49. http://dx.doi.org/10.5603/njo.2019.0027.

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Falandry, Claire, Eric Gilson e K. Lenhard Rudolph. "Are aging biomarkers clinically relevant in oncogeriatrics?" Critical Reviews in Oncology/Hematology 85, n. 3 (marzo 2013): 257–65. http://dx.doi.org/10.1016/j.critrevonc.2012.08.004.

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Cudennec, T., S. Moulias, S. Labrune, T. Chinet e L. Teillet. "P.9 Oncogeriatrics in pneumology a growing activity". Critical Reviews in Oncology/Hematology 64 (novembre 2007): S38. http://dx.doi.org/10.1016/s1040-8428(13)70182-3.

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López Pardo, P., M. M. Cavanagh Podesta, A. M. Sánchez Peña, M. Soria Tristán, L. Díaz Paniagua, S. Enrech Francés, M. T. Díaz Puente, J. M. Martín Martínez e P. López-Dóriga Bonnardeaux. "Prevalence of Cognitive Impairment in our Oncogeriatrics Program". Journal of Geriatric Oncology 13, n. 8 (ottobre 2022): S69. http://dx.doi.org/10.1016/s1879-4068(22)00408-8.

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Katsila, Theodora, George P. Patrinos e Dimitrios Kardamakis. "Searching for Clinically Relevant Biomarkers in Geriatric Oncology". BioMed Research International 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/3793154.

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Ageing, which is associated with a progressive decline and functional deterioration in multiple organ systems, is highly heterogeneous, both inter- and intraindividually. For this, tailored-made theranostics and optimum patient stratification become fundamental, when decision-making in elderly patients is considered. In particular, when cancer incidence and cancer-related mortality and morbidity are taken into account, elderly patient care is a public health concern. In this review, we focus on oncogeriatrics and highlight current opportunities and challenges with an emphasis on the unmet need of clinically relevant biomarkers in elderly cancer patients. We performed a literature search on PubMed and Scopus databases for articles published in English between 2000 and 2017 coupled to text mining and analysis. Considering the top insights, we derived from our literature analysis that information knowledge needs to turn into knowledge growth in oncogeriatrics towards clinically relevant biomarkers, cost-effective practices, updated educational schemes for health professionals (in particular, geriatricians and oncologists), and awareness of ethical issues. We conclude with an interdisciplinary call to omics, geriatricians, oncologists, informatics, and policy-makers communities that Big Data should be translated into decision-making in the clinic.

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André, Louise, Gabriel Antherieu, Amélie Boinet, Judith Bret, Thomas Gilbert, Rabia Boulahssass e Claire Falandry. "Oncological Treatment-Related Fatigue in Oncogeriatrics: A Scoping Review". Cancers 14, n. 10 (17 maggio 2022): 2470. http://dx.doi.org/10.3390/cancers14102470.

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Fatigue is a highly prevalent symptom in both cancer patients and the older population, and it contributes to quality-of-life impairment. Cancer treatment-related fatigue should thus be included in the risk/benefit assessment when introducing any treatment, but tools are lacking to a priori estimate such risk. This scoping review was designed to report the current evidence regarding the frequency of fatigue for the different treatment regimens proposed for the main cancer indications, with a specific focus on age-specific data, for the following tumors: breast, ovary, prostate, urothelium, colon, lung and lymphoma. Fatigue was most frequently reported using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) versions 3 to 5. A total of 324 regimens were analyzed; data on fatigue were available for 217 (67%) of them, and data specific to older patients were available for 35 (11%) of them; recent pivotal trials have generally reported more fatigue grades than older studies, illustrating increasing concern over time. This scoping review presents an easy-to-understand summary that is expected to provide helpful information for shared decisions with patients regarding the anticipation and prevention of fatigue during each cancer treatment.

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Kenig, Jakub. "Oncogeriatrics (part 1.). Frailty in older adults with cancer". Nowotwory. Journal of Oncology 69, n. 2 (2 agosto 2019): 55–57. http://dx.doi.org/10.5603/njo.2019.0010.

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Rashid, Ahmed. "Yonder: Oncogeriatrics, binge eating in black women, dissection, and podcasts". British Journal of General Practice 70, n. 694 (30 aprile 2020): 246. http://dx.doi.org/10.3399/bjgp20x709697.

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Kenig, Jakub. "Oncogeriatrics (part 3.) Influence of surgical trauma on older patients". Nowotwory. Journal of Oncology 69, n. 5-6 (31 dicembre 2019): 163–67. http://dx.doi.org/10.5603/njo.2019.0030.

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Kenig, Jakub, e Kinga Szabat. "Oncogeriatrics (part 7.). Geriatric assessment for older patients with cancer". Nowotwory. Journal of Oncology 70, n. 4 (27 luglio 2020): 153–57. http://dx.doi.org/10.5603/njo.2020.0031.

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Kenig, Jakub. "Oncogeriatrics (part 4.) Pre-operative assessment of elderly patients with cancer". Nowotwory. Journal of Oncology 70, n. 1 (3 marzo 2020): 16–19. http://dx.doi.org/10.5603/njo.2020.0003.

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Monacelli, Fiammetta, Alessio Signori, Matteo Prefumo, Chiara Giannotti, Alessio Nencioni, Emanuele Romairone, Stefano Scabini e Patrizio Odetti. "Delirium, Frailty, and Fast-Track Surgery in Oncogeriatrics: Is There a Link?" Dementia and Geriatric Cognitive Disorders Extra 8, n. 1 (7 febbraio 2018): 33–41. http://dx.doi.org/10.1159/000486519.

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Background/Aims: Postoperative delirium (POD) is more frequent in elderly patients undergoing major cancer surgery. The interplay between individual clinical vulnerability and a series of perioperative factors seems to play a relevant role. Surgery is the first-line treatment option for cancer, and fast-track surgery (FTS) has been documented to decrease postoperative complications. The study sought to assess, after comprehensive geriatric assessment (CGA) and frailty stratification (Rockwood 40 items index), which perioperative parameters were predictive of POD development in elderly patients undergoing FTS for colorectal cancer. Methods: A total of 107 consecutive subjects admitted for elective colorectal FTS were enrolled. All patients underwent CGA, frailly stratification, Timed up & go (TUG) test, 4AT test for delirium screening, anesthesiologists physical status classification, and Dindo-Clavien classification. Results: The incidence of POD was 12.3%. Patients’ prevalent clinical phenotype was pre-frail. The multivariate analysis indicated physical performance (TUG in seconds) as the most significant predictor of POD for each second of increase. Conclusions: Only few procedure-specific studies have examined the impact of FTS for colorectal cancer on POD. This is the first study to investigate the risk factors for POD, in a vulnerable octogenarian oncogeriatric population submitted to FTS surgery and frailty stratification.

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Monacelli, F., C. Giannotti, G. Zoppoli, L. Ferrando, R. Murialdo, S. Scabini, R. Murialdo et al. "PREDICTORS OF 1-YEAR MORTALITY IN ONCOGERIATRICS: DEVELOPMENT OF AN ONCOLOGICAL PROGNOSTIC INDEX". Journal of Geriatric Oncology 10, n. 6 (novembre 2019): S70—S71. http://dx.doi.org/10.1016/s1879-4068(19)31235-4.

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Caglevic, Christian, Macarena Honorato, Oscar Calderón, Verónica Rojas, Gerardo Fasce e Constanza Bartolotti. "Considerations and Analysis of the Implementation of Oncogeriatrics in Chile and Its Importance". Biomedical and Clinical Research 1, n. 1 (17 ottobre 2022): 01–07. http://dx.doi.org/10.31579/2834-8486/001.

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The Chilean census of 2017 reported that 11.4% of the local population are 65 years or older, and according to the National Institute of Statistics (INE) by 2025 20% of the Chilean population will be in this group. Cancer in Chile is a major public health problem. Aging is a significant risk factor for cancer development which added to the improved life expectancy, it increases the incidence of cancer. In 2040, new cancer cases will increase from 19.3 to 30.2 million worldwide. Older people are a heterogeneous group requiring specialized and individualized management. Chronological age does not necessarily correlate with physiological age. More than half of the geriatric patients with cancer have at least one comorbidity which is relevant when defining a cancer treatment. Likewise, polypharmacy is frequent and is an important issue to consider in people with cancer due to the risk associated with drug interactions. Oncogeriatric assessment consists of a comprehensive multidimensional evaluation, including functional and biopsychosocial issues, addressing aspects of the neoplastic disease such as the risk of toxicities due to systemic therapy and life expectancy. This tool has proven to be helpful in the diagnosis of conditions that are not evident in a routine oncological evaluation, such as geriatric syndromes, frailty, functional dependence, and cognitive impairment among others, which have an impact when deciding on therapy, predicting risks of treatment toxicity and mortality.

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Mendoza-Moreno, Fernando, Belén Matías-García, Ana Quiroga-Valcárcel, Eduardo Serrano-Yébenes, Yousef Allaoua-Moussaoui, Cristina Vera-Mansilla, Alma Blázquez-Martín et al. "Surgical oncogeriatrics: Is the elderly patient more vulnerable after colectomy than the middle-aged patient?" European Journal of Surgical Oncology 49, n. 2 (febbraio 2023): e135. http://dx.doi.org/10.1016/j.ejso.2022.11.384.

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Molina-Garrido, Maria-Jose, Carmen Guillén-Ponce, Remei Blanco, Juana Saldaña, Jaime Feliú, Maite Antonio, Rosa López-Mongil, Primitivo Ramos Cordero e Regina Gironés. "Delphi consensus of an expert committee in oncogeriatrics regarding comprehensive geriatric assessment in seniors with cancer in Spain". Journal of Geriatric Oncology 9, n. 4 (luglio 2018): 337–45. http://dx.doi.org/10.1016/j.jgo.2017.11.012.

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Kenig, Jakub, Jerzy Mituś e Kamil Rapacz. "Oncogeriatrics (part 6.). The usefulness of routine preoperative investigations in the qualification of an older patient for elective surgery". Nowotwory. Journal of Oncology 70, n. 3 (16 giugno 2020): 101–4. http://dx.doi.org/10.5603/njo.2020.0022.

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Foley, Rose-Anna, Lucie Lechevalier Hurard, Annick Anchisi e Sandro Anchisi. "Rising to the medication's requirements: The experience of elderly cancer patients receiving palliative chemotherapy in the elective oncogeriatrics field". Social Science & Medicine 242 (dicembre 2019): 112593. http://dx.doi.org/10.1016/j.socscimed.2019.112593.

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Heudel, Pierre, Mashal Ahmed e Felix Renard. "Abstract PO5-21-04: Leveraging Digital Twins for Patient Stratification and Treatment Optimization in geriatric oncology: A Breast Cancer Multivariate Clustering Analysis". Cancer Research 84, n. 9_Supplement (2 maggio 2024): PO5–21–04—PO5–21–04. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-21-04.

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Abstract Context: Geriatric oncology necessitates an accurate evaluation of a patient's health status and cancer characteristics. Digital twins, virtual replicas of a patient and their cancer, can aid in predicting real-world behaviors and support therapeutic decision-making. Objectives: This study aims to demonstrate how digital twins can optimize treatments by simulating various scenarios based on the individual characteristics of patients and their cancers. Methods: Creation of a digital twin relies on the use of advanced manifold learning technologies. A model is built to represent the variability present in the reference cohort, capturing complex relationships and inherent data structures. A reference digital twin is generated by drawing samples from this model, thus reflecting the characteristics distribution of the reference population. Stratification (MeanShift algorithm) enables cohort structure visualization and classical statistics estimation for each stratum. Multivariate analysis was performed on a French monocentric population of 1345 patients aged over 70 years who underwent surgery for HER2-negative early breast cancer. Results: 8 cluster, created by manifold learning based on biological, demographic, and tumoral variables, exhibits unique five-year survival rates and influential factors. The clusters represent specific patient subgroups, each with its distinct set of characteristics and prognostic indicators. Table 1 provides a summary of these variables' averages within each cluster. we can thus see that the variables of clusters 3 and 6 (including only HR+ cancers) do not show statistically significant differences, unlike their 5-year survival rates (cluster 3 : 80,9% (CI95 :70-88.5) and 63.9% (CI95 :47.6-77.5) for cluster 6, p= 0,04). Provided with model results, the relative importance of these variables varies from one cluster to another, underscoring the heterogeneity among patient subgroups. Interestingly, Hormonal receptor status, nodal involvement and tumoral grade were not the predominant variables in these clusters, which challenges traditional perspectives. Table 1 : Mean value of variables per cluster (SBR grade 0=grade 1 and 2 ; 1= grade 3) Discussion: The findings underscore the vast variability of individual variable importance across clusters. Digital twins enabled the modeling of these complex interactions, providing valuable insights for clinical decision-making. Conclusion: Digital twins offer a valuable tool for personalizing care in oncogeriatrics, facilitating the identification of patient subgroups, yielding more accurate treatment outcomes, and guiding future research directions. The results affirm that incorporating digital twins into oncogeriatric care could potentially lead to the enhanced personalization of therapeutic approaches, ultimately improving patient outcomes. Table. Citation Format: Pierre Heudel, Mashal Ahmed, Felix Renard. Leveraging Digital Twins for Patient Stratification and Treatment Optimization in geriatric oncology: A Breast Cancer Multivariate Clustering Analysis [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-21-04.

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Artiles-Medina, A., e F. J. Burgos-Revilla. "Limitations and challenges of uro-oncologic surgery in elderly patients: A critical review of the management of prostate, bladder and kidney cancer". ANALES RANM 139, n. 139(01) (30 aprile 2022): 43–55. http://dx.doi.org/10.32440/ar.2022.139.01.rev05.

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Due to the increase in life expectancy, challenging scenarios in oncogeriatrics are becoming more common in clinical practice. The outcomes of curative cancer treatments, which have shown benefits in the general population, are not always studied in elderly patients. Chronological age alone may not accurately correlate with the risk of complications or the potential benefit in survival, in contrast to the increasingly used frailty scores. Therefore, an adequate preoperative comprehensive geriatric assessment is essential. This review addresses the challenge of decision-making regarding surgical treatment of the most frequent urological cancers in elderly patients. Prostate cancer in elderly patients implies a complex scenario; life expectancy represents a determining factor given its often indolent behavior, in order to avoid overtreatment. It is crucial to face this challenge focusing on cancer screening primarily. In the literature, there are heterogeneous data regarding survival, although a similar rate of surgical complications and worse functional outcomes than younger patients have been reported. Muscle-invasive bladder cancer in the elderly also represents a challenge, because of the high rate of complications of radical cystectomy and the evidence of lower overall and cancer-specific survival in this group of patients. Finally, the key elements in the management of kidney cancer in elderly patients who are candidates for surgical treatment are the need to preserve renal function (considering nephron-sparing surgery) and the limited data regarding benefit in overall survival. For this reason, active surveillance of small renal masses can be a useful strategy.

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Molina-Garrido, Maria José, e Carmen Guillén-Ponce. "Ability of the Comprehensive Geriatric Assessment to Predict Frailty in Older People Diagnosed with Cancer in a General Hospital". European Oncology & Haematology 08, n. 02 (2012): 85. http://dx.doi.org/10.17925/eoh.2012.08.02.85.

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The field of oncogeriatrics considers the comprehensive geriatric assessment (CGA) as the main tool for distinguishing between patients who are frail and those who are not frail. The aim of our study was to determine the role of the CGA in predicting the risk of frailty in elderly patients. This prospective study was conducted at the Cancer in the Elderly Unit of the Medical Oncology Department at the Virgen de la Luz General Hospital in Cuenca, Spain. Demographic data and information about the CGA were collected. Using a bivariate logistic regression analysis, these factors were analysed and the factors that are associated with the risk of frailty were determined, as measured by the Barber questionnaire (BQ). We included 262 patients in the study with a mean age of 79 years (range 7093 years). Seventy-four percent of the patients (n=194) had a risk of frailty as measured by the BQ. In the bivariate analysis, only age (odds ratio [OR] 1.064, 95 % confidence interval [CI] 1.0001.133, p=0.051), being divorced, widowed or single (OR 0.450, 95 % CI 0.2160.937, p=0.033) and being dependent in instrumental activities of daily living (IADL) (OR 3.003, 95 % CI 1.1817.638, p=0.021) were associated with a higher risk of frailty. The risk of being frail in an elderly patient with cancer is higher in patients dependent in IADL and in patients who are not married. Age is another risk factor for frailty.

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Roche, Mélanie, Christine Ravot, Amélie Malapert, Sophie Paget-Bailly, Charlène Garandeau, Virginie Pitiot, Mélanie Tomatis et al. "Feasibility of a prehabilitation programme dedicated to older patients with cancer before complex medical–surgical procedures: the PROADAPT pilot study protocol". BMJ Open 11, n. 4 (aprile 2021): e042960. http://dx.doi.org/10.1136/bmjopen-2020-042960.

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BackgroundAgeing is associated with an increased prevalence of comorbidities and sarcopenia as well as a decline of functional reserve of multiple organ systems, which may lead, in the context of the disease-related and/or treatment-related stress, to functional deconditioning. The multicomponent ‘Prehabilitation & Rehabilitation in Oncogeriatrics: Adaptation to Deconditioning risk and Accompaniment of Patients’ Trajectories (PROADAPT)’ intervention was developed multiprofessionally to implement prehabilitation in older patients with cancer.MethodsThe PROADAPT pilot study is an interventional, non-comparative, prospective, multicentre study. It will include 122 patients oriented to complex medical–surgical curative procedures (major surgery or radiation therapy with or without chemotherapy). After informed consent, patients will undergo a comprehensive geriatric assessment and will be offered a prehabilitation kit that includes an advice booklet with personalised objectives and respiratory rehabilitation devices. Patients will then be called weekly and monitored for physical and respiratory rehabilitation, preoperative renutrition, motivational counselling and iatrogenic prevention. Six outpatient visits will be planned: at inclusion, a few days before the procedure and at 1, 3, 6 and 12 months after the end of the procedure. The main outcome of the study is the feasibility of the intervention, defined as the ability to perform at least one of the components of the programme. Clinical data collected will include patient-specific and cancer-specific characteristics.Ethics and disseminationThe study protocol was approved by the Ile de France 8 ethics committee on 5 June 2018. The results of the primary and secondary objectives will be published in peer-reviewed journals.Trial registration numberNCT03659123. Pre-results of the trial.

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de Boer, Anna Z., Willemien van de Water, Esther Bastiaannet, Nienke A. de Glas, Mandy Kiderlen, Johanneke E. A. Portielje e Martine Extermann. "Early stage breast cancer treatment and outcome of older patients treated in an oncogeriatric care and a standard care setting: an international comparison". Breast Cancer Research and Treatment 184, n. 2 (19 agosto 2020): 519–26. http://dx.doi.org/10.1007/s10549-020-05860-7.

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Abstract Introduction Since older patients with breast cancer are underrepresented in clinical trials, an oncogeriatric approach is advocated to guide treatment decisions. However, the effect on outcomes is unclear. The aim of this study was to compare treatments and outcomes between patients treated in an oncogeriatric and a standard care setting. Methods Patients aged ≥ 70 years with early stage breast cancer were included. The oncogeriatric cohort comprised unselected patients from the Moffitt Cancer Center, and the standard cohort patients from a Dutch population-based cohort. Cox models were used to characterize the influence of care setting on recurrence risk and overall mortality. Results Overall, 268 patients were included in the oncogeriatric and 1932 patients in the standard cohort. Patients in the oncogeriatric cohort were slightly younger, had more comorbidity, and received more adjuvant endocrine therapy and chemotherapy. Oncogeriatric care was associated with a lower risk of recurrence, which remained significant after adjustment for patient and tumour characteristics [hazard ratio (HR) 0.66, 95% confidence interval (CI) 0.44–0.99]. Oncogeriatric care was also associated with a lower overall mortality, which also remained significant after adjustment for patient and tumour characteristics (HR 0.69, 95% CI 0.55–0.87). Conclusions Patients treated in the oncogeriatric care setting had a lower risk of recurrence, which may be explained by more systemic treatment. Overall mortality was also lower, but other explanations besides care setting could not be ruled out as the cohorts had different patient profiles. Future studies need to clarify the impact of an oncogeriatric approach on outcomes.

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Focan, C., E. Warzée, C. Sondag e T. Guillaume. "Evaluation of biological rhythms in elderly cancer patients. A complementary translational research within the frame of the trans-hospital pilot program of oncogeriatrics launched at CHC–Liège". Pathologie Biologie 61, n. 2 (aprile 2013): e33-e37. http://dx.doi.org/10.1016/j.patbio.2011.01.001.

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Domingues Dziedicz, Daniella. "Home Enteral Nutrition in Oncogeriatry: Infusion versus Energy Needs". Gerontology & Geriatric Medicine 7, n. 1 (5 marzo 2021): 1–6. http://dx.doi.org/10.24966/ggm-8662/100086.

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Purpose: Oncogeriatric patients use enteral nutrition as an alternative means to supply the energy intake required. The aim of this study was to verify the nutritional energy delivery compared to the energy needs of oncogeriatric patients in home care.

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Metges, J. P., M. A. Lebot, R. Faroux, F. Riaud, E. Gamelin, O. Capitain, V. Guérin Meyer et al. "Evaluation in usual practice of the bevacizumab-FOLFIRI combination for the first-line treatment of patients with unresectable metastatic colorectal cancer treated in 2006: focus on resected patients and oncogeriatrics". Oncologie 16, n. 5 (maggio 2014): 267–76. http://dx.doi.org/10.1007/s10269-014-2391-1.

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32

Todi, F., S. Rotunno, M. V. Zoffoli, F. Satta, E. Burattini, G. Coiro, A. Pellegrino, L. Marchetti e M. Di Palma. "Oncogeriatric Unit: our experience". Annals of Oncology 27 (settembre 2016): iv121. http://dx.doi.org/10.1093/annonc/mdw345.51.

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33

Niemier, J. Y., C. Perret-Guillame, H. Rousselot, I. Krakowski e A. Benetos. "Oncogeriatric activity in Lorraine, France: Organization of a regional oncogeriatric coordination unit". European Geriatric Medicine 4 (settembre 2013): S169. http://dx.doi.org/10.1016/j.eurger.2013.07.566.

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Niemier, J. Y., C. Perret-Guillaume, H. Rousselot, I. Krakowski e A. Benetos. "Oncogeriatric activity in Lorraine, France: Oganization of a regional oncogeriatric coordination unit". Journal of Geriatric Oncology 4 (ottobre 2013): S103. http://dx.doi.org/10.1016/j.jgo.2013.09.182.

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35

Saraiva Torres, Tatiana, Dani Ellen Fernandes da Costa, Natally Suellen Ladislau Ortiz e Nathan Aratani. "Cuidados ao fim da vida em pacientes oncogeriátricos recebendo cuidados paliativos". Perspectivas Experimentais e Clínicas Inovações Biomédicas e Educação em Saúde (PECIBES) ISSN - 2594-9888 9, n. 2 (31 dicembre 2023): 18. http://dx.doi.org/10.55028/pecibes.v9i2.20038.

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Abstract (sommario):

Introdução: O câncer, doença crônica não transmissível, vem alcançando patamares alarmantes, e de acordo com a Sociedade Brasileira de Geriatria e Gerontologia a população idosa correspondente a 60% dos brasileiros com câncer, e cerca de 70% das mortes decorrentes nessa faixa etária decorre do câncer de próstata, nos homens, e de mama nas mulheres1. Diante disso, os cuidados aos pacientes oncogeriatricos deixam de ser apenas curativos e passam a receber cuidados paliativos, tendo como foco principal o controle dos sintomas da doença e alívio do sofrimento, promovendo a melhora na qualidade de vida2. Objetivo: Analisar como os cuidados paliativos têm sido aplicados a pacientes oncogeriatricos no Brasil. Método: Pesquisa do tipo revisão integrativa, que teve como intenção responder a questão norteadora como assistir o fim da vida em idosos oncológicos?. A busca ocorreu entre os meses de Agosto a Novembro de 2020 nos portais da Scielo e Biblioteca Virtual em Saúde, considerando os descritores “idosos oncológicos”, “oncogeriatria” e “cuidados paliativos”, e como recorte temporal publicações entre os anos de 2015 e 2020. Resultados: Os cuidados paliativos devem ser empregados em pacientes idosos logo após receberem o diagnóstico de câncer, estejam eles em estado terminal ou não, visando promover qualidade de vida no processo de adoecimento. Entre os cuidados aplicados está o alívio do sofrimento, na perspectiva de uma assistência integral, respeitando a vontade do paciente ou de seu representante legal, auxiliar o doente a desfrutar de possíveis realizações pessoais durante o enfrentamento da doença e nos últimos momentos da vida, sendo fundamental considerar o paciente como um ser único, complexo e multidimensional3. Nessa perspectiva, as atividades assistenciais prestadas aos pacientes incluem a avaliação sistemática dos sinais e sintomas, a dinâmica da interação familiar, conforto por meio da escuta ativa e empática, a fim de conhecer as expectativas, os anseios, os medos e as preocupações do paciente e de sua família para que se apoie no emprego da comunicação clara e cuidadosa, efetivo controle dos sintomas, atuação interdisciplinar e suporte à família durante todas as etapas do acompanhamento, inclusive no luto2,3. O cuidar no fim da vida busca assegurar a dignidade e conforto até o último minuto da vida do paciente, para isso deve-se tomar decisões com clareza, aproveitar o tempo para rever e dar significados a vida, realizar despedidas, resolver conflitos, passar mais tempo com familiares e amigos, deixar um legado, receber cuidados consistentes de acordo com as necessidades clínicas e de acordo com os desejos do paciente2. Além de assegurar a higiene do paciente3. Conclusão: Ainda é um desafio para as famílias tomar decisões de conduta sobre a assistência paliativista, o que representa um obstáculo para a equipe de saúde. Para reverter esse quadro é necessário adoção da disseminação de informações sobre quais ações e intervenções de cuidados podem ser realizadas, elencando as vantagens da assistência paliativista.

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Smith, D., M. Rouyer, P. Noize, R. Lassalle, O. Bernard, F. Burki, P. Guichard, A. Ravaud, N. Moore e A. Fourrier-Ráglat. "Effectiveness and safety in very elderly patients treated by bevacizumab (BV) plus chemotherapy in first-line therapy of metastatic colorectal cancer: Results of ETNA, a French cohort study." Journal of Clinical Oncology 29, n. 4_suppl (1 febbraio 2011): 555. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.555.

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555 Background: In view of the ageing population, oncogeriatrics has become a priority for public health. Elderly cancer patients are often excluded from clinical trials and there is no therapeutic standard for their care management. Cohort studies have been conducted in US and Europe but not in France. The ETNA study aimed to describe BV use and survival outcomes in real-life practice. Here, the population aged >75 years was compared to that aged >75. Methods: ETNA is a cohort study conducted in 28 French centers that included 411 patients initiating BV between Jan 2006 and Dec 2007, with 24 month follow-up. Results: Fifty-one patients (12.4%) of the cohort were over 75 years old: mean age 78.3 years (vs 61.9 years for the rest of the cohort), male 66.7% (vs 56.1%), ECOG≥2 17.6% (vs 10.8%). BV was combined with FOLFIRI/XELIRI in 88.2% of patients aged >75 years (vs 87.5%) and FOLFOX/XELOX in 11.8% (vs 12.2%). Median duration of BV treatment was 5.6 months (m) (vs 5.5 m), and median duration of the 1st-line was 10.3 m (vs 9.8 m). More patients >75 years had treatment-free intervals (39.2% vs 28.6%), and 13.7% had a maintenance therapy (vs 12.8%). Curative surgery performed in 15.7% of patients (vs. 20.6%). Among the 43 patients who discontinued the 1st-line, only 9.3% discontinued BV prematurely (vs 18.2%). The incidence of any grade-3/4 adverse event was 43.1% (vs 41.7%). In-line with the known safety profile of BV (any grade), hypertension was observed in 21.6% (vs 18.9%), proteinuria 23.5% (vs 27.2%), there were no GI perforations (vs 0.3%), thrombotic events 5.9% (vs 7.8%), and grade 3/4 arterial thrombotic events 2.0% (vs 0.6%). The 1-year OS rate was 78.0%, 95%CI [63.9-87.2] (vs 80.5%, 95%CI [76.0-84.2]) and the median OS was not reached for both groups. The median PFS was 10.6 m, 95%CI [9.0-12.8] (vs 9.9 m, 95%CI [9.3-11.1]). Conclusions: Effectiveness and safety of BV plus chemotherapy in elderly patients were similar to those of the rest of the ETNA cohort. Estimations of survival outcomes (1-year OS rate, median OS and PFS) were also comparable to those found in elderly patients (75-80 years) from the BRITE cohort (72.0%, 20.3 m and 10.0 m, respectively). No significant financial relationships to disclose.

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Batista Pereira, Esdras Edgar. "Functional Capacity Assessment in Oncogeriatric". American Journal of Biomedical Science & Research 5, n. 6 (21 ottobre 2019): 455–56. http://dx.doi.org/10.34297/ajbsr.2019.05.000965.

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Kenig, Jakub. "Oncogeriatric. Other frailty assessment instruments". Nowotwory. Journal of Oncology 70, n. 6 (4 dicembre 2020): 267–71. http://dx.doi.org/10.5603/njo.2020.0052.

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Audisio, Riccardo A., Andrew P. Zbar e Michael T. Jaklitsch. "Surgical Management of Oncogeriatric Patients". Journal of Clinical Oncology 25, n. 14 (10 maggio 2007): 1924–29. http://dx.doi.org/10.1200/jco.2006.10.2533.

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Major changes are taking place at a great pace in modern medicine, and surgical oncologists are at the forefront when new skills are to be tested and implemented. Perhaps the most significant change we are facing relates to the aging of our population, with most solid tumors presenting at age 70 years (± 5 years). The demographics and epidemiological details are covered in the appropriate sections of this special issue, but it is important to realize how such a shift influences our day-to-day practice. These principally are occurring in improved anesthetic care, minimally invasive surgery, nonoperative therapies, risk assessment, and quality-of-life estimates.

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40

Terret, Catherine, e Jean-Pierre Droz. "Development of Oncogeriatry – A European Perspective from the French Experience". European Oncology & Haematology 05, n. 01 (2009): 84. http://dx.doi.org/10.17925/eoh.2009.05.1.84.

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Oncogeriatry is the clinical discipline concerned with the management of elderly cancer patients. It is based on a global oncological and geriatric approach to the health status of patients. Oncogeriatry has been widely adopted throughout the world, but the approaches used and the organisational solutions provided are complex and varied. Based on the French experience of a centralised health system, the different aspects are discussed: clinical management, organisation, clinical research and information. At a European level, the best approach seems to be a partnership between the International Society of Geriatric Oncology and the Elderly Task Force of the European Organisation on Research and Treatment of Cancer. This co-operation ensures comprehensive information on oncogeriatric programmes, clinical research and teaching programmes, thus enhancing the effectiveness of the oncogeriatric approach.

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41

Arnal Rondan, M., G. Suay Montagud, D. Polo Soriano, A. Ferrero Mico, F. J. Perea Rojo, J. Linares Diaz, N. Gomez Sepulveda, R. Girones Sarrio e O. Juan Vidal. "Oncogeriatric Consultation. Experience of our Section". Journal of Geriatric Oncology 13, n. 8 (ottobre 2022): S64—S65. http://dx.doi.org/10.1016/s1879-4068(22)00396-4.

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42

Basterretxea Badiola, Laura, Helis Telleria Soret, Jennifer Gomez Mediavilla e Ibone De Elejoste Echeverria. "Frailty screening and relationship with oncogeriatric evaluation". International Journal of Integrated Care 19, n. 4 (8 agosto 2019): 301. http://dx.doi.org/10.5334/ijic.s3301.

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43

Lidouren, G., V. Ratsimbazafy, J. Martin, M. Javerliat e N. Tubiana-Mathieu. "20 Pharmacy services in a oncogeriatric unit". Critical Reviews in Oncology/Hematology 60 (novembre 2006): S31—S32. http://dx.doi.org/10.1016/s1040-8428(13)70091-x.

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Chauvin, V. Dougoud, N. Szüts, A. Laszlo e D. C. Betticher. "THE IMPLEMENTATION OF A NEW ONCOGERIATRIC CONSULTATION". Journal of Geriatric Oncology 10, n. 6 (novembre 2019): S104—S105. http://dx.doi.org/10.1016/s1879-4068(19)31294-9.

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Dodkins, Joanna, Adrian Cook, Melanie Morris, Julie Nossiter, Steve Prust, Steve Waller, Jan van der Meulen, Ajay Aggarwal, Noel Clarke e Heather Ann Payne. "Organisation and delivery of supportive services for patients with prostate cancer in the National Health Service in England and Wales: a national cross-sectional hospital survey and latent class analysis". BMJ Open 13, n. 11 (novembre 2023): e071674. http://dx.doi.org/10.1136/bmjopen-2023-071674.

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Abstract (sommario):

ObjectivesWe assessed how often National Health Service (NHS) hospitals reported that they had specific supportive services for patients with prostate cancer available onsite, including nursing support, sexual function and urinary continence services, psychological and genetic counselling, and oncogeriatric services. We identified groups of hospitals with similar patterns of supportive services.Design/settingWe conducted an organisational survey in 2021 of all NHS hospitals providing prostate cancer services in England and Wales. Latent class analysis grouped hospitals with similar patterns of supportive services.ResultsIn 138 hospitals, an advanced prostate cancer nurse was available in 125 hospitals (90.6%), 107 (77.5%) had a clinical nurse specialist (CNS) attending all clinics, 103 (75.7%) had sexual function services, 111 (81.6%) had continence services and 93 (69.4%) psychological counselling. The availability of genetic counselling (41 hospitals, 30.6%) and oncogeriatric services (15 hospitals, 11.0%) was lower. The hospitals could be divided into three groups. The first and largest group of 85 hospitals provided the most comprehensive supportive services onsite: all hospitals had a CNS attending all clinics, 84 (98.8%) sexual function services and 73 (85.9%) continence services. A key characteristic of the second group of 31 hospitals was that none had a CNS attending all clinics. A key characteristic of the third group of 22 hospitals was that none had sexual function services available. The hospitals in the largest group were more likely to run joint clinics (p<0.001) and host the regional specialist multidisciplinary team (p=0.002).ConclusionsThere is considerable variation in supportive services for prostate cancer available onsite in NHS hospitals in England and Wales. Availability of genetic counselling and oncogeriatric services is low. The different patterns of supportive services among hospitals demonstrate that initiatives to improve the availability of the entire range of supportive services to all patients should be carefully targeted.

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Audisio, Riccardo A., Hodigere Ramesh, Walter E. Longo, Andrew P. Zbar e Daniel Pope. "Preoperative Assessment of Surgical Risk in Oncogeriatric Patients". Oncologist 10, n. 4 (aprile 2005): 262–68. http://dx.doi.org/10.1634/theoncologist.10-4-262.

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Slee-Valentijn, M. S., K. S. Versteeg, A. B. Maier, H. M. Verheul e I. R. Konings. "Towards an objective longitudinal assessment of oncogeriatric outpatients". Journal of Geriatric Oncology 4 (ottobre 2013): S84. http://dx.doi.org/10.1016/j.jgo.2013.09.141.

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Parker, H., S. Birchenough, U. Barthakur e E. Cattell. "Ascertaining the need for an oncogeriatric service, and the subsequent launch of an oncogeriatric MDT (multi-disciplinary team) in Somerset, UK". Journal of Geriatric Oncology 12, n. 8 (dicembre 2021): S47—S48. http://dx.doi.org/10.1016/s1879-4068(21)00419-7.

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van Leeuwen, B. L., S. R. Kristjansson e R. A. Audisio. "Should specialized oncogeriatric surgeons operate older unfit cancer patients?" European Journal of Surgical Oncology (EJSO) 36 (settembre 2010): S18—S22. http://dx.doi.org/10.1016/j.ejso.2010.06.018.

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50

Mackey, Rosewellv, e Gopal Chandru Kowdley. "Treatment Practices and Outcomes of Elderly Women with Breast Cancer in a Community Hospital". American Surgeon 80, n. 7 (luglio 2014): 714–19. http://dx.doi.org/10.1177/000313481408000729.

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Abstract (sommario):

There is a paucity of clinical data available on specific treatment in the oncogeriatric population with breast cancer. The purpose of this study was to evaluate treatment patterns and survival outcomes in the elderly to address any disparities at our community hospital. We retrospectively identified a total of 1749 patients diagnosed and treated for breast cancer at our institution between 2001 and 2011. Patient demographics, surgical treatment, stage of disease, tumor characteristics, adjuvant therapy, and 5-year survival data were obtained from tumor registry records. Comparisons between study groups were made using the Pearson χ2 test and Student's t test. We found more favorable prognostic makers among women older than 70 years of age. Of the women with lymph node-positive disease, 84 per cent of those younger than 70 years and 33 per cent in the older than 70 years of age study group received chemotherapy. Adjuvant chemotherapy and radiation therapy were more frequently performed in the younger group. Overall 5-year survival was 90 per cent and 71 per cent for younger than 70 years and older than 70 years groups, respectively. Women older than 70 years of age have more favorable breast cancer characteristics compared with younger women and received less aggressive treatment and experienced a higher mortality rate. Prospective trials are needed to assess the impact of aggressive multimodality therapy in this oncogeriatric population.

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