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Letteratura scientifica selezionata sul tema "Nitric oxide – Physiological effect"

Autore: Grafiati
Pubblicato: 4 giugno 2021
Ultima modifica: 1 febbraio 2023

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Articoli di riviste sul tema "Nitric oxide – Physiological effect"

1

Smiljic, Sonja, Vojkan Nestorovic e Sladjana Savic. "Modulatory role of nitric oxide in cardiac performance". Medical review 67, n. 9-10 (2014): 345–52. http://dx.doi.org/10.2298/mpns1410345s.

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Abstract (sommario):
Nitric oxide is produced by almost all cardiac cells, endothelial cells, cardiomyocytes and nerve fibers. It is synthesized by an enzyme, a nitric oxide synthase, which occurs in endothelial, neural and inducible form. The distribution of nitric oxide synthase in the heart is characterized by a pronounced non-uniformity. Nitric oxide exerts its effects in physiological and pathophysiological conditions. The physiological effects of low concentrations of nitric oxide, which is released in the normal conditions under the influence of constituent enzymes, occur via cyclic guanosine monophosphate. The synthesized nitric oxide exhibits its effect in the cells where it is produced, in an autocrine manner, or by diffusing into the neighboring cells, in a paracrine manner. Nitric oxide acts by regulating the coronary vessel tonus, affecting the contractility of cardiomyocytes, generating an inotropic effect in a dose-dependent manner and controlling the cellular respiration. Other effects of nitric oxide in the cardiovascular system include the hyperpolarization of the smooth muscle cells in blood vessels, the inhibition of the monocyte adhesion, the inhibition of platelet migration, adhesion and aggregation and the proliferation of smooth muscle cells and fibroblasts. The anti-atherosclerotic effects of nitric oxide are based on these effects. Nitric oxide is a weak free radical in gaseous state, and the cytotoxic and/or the cytoprotective effects of the higher concentrations of nitric oxide are related to the chemical structure of nitric oxide as a free radical. The excessive production of nitric oxide by the activation of inducible nitric oxide synthase can lead to major irregularities in the function of cardiomyocytes and cardiac insufficiency. Understanding the nitric oxide molecular mechanisms of signaling pathways in the heart can provide a new strategic approach to prevention and treatment of cardiovascular diseases.
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Ukeri, John, Michael T. Wilson e Brandon J. Reeder. "Modulating Nitric Oxide Dioxygenase and Nitrite Reductase of Cytoglobin through Point Mutations". Antioxidants 11, n. 9 (15 settembre 2022): 1816. http://dx.doi.org/10.3390/antiox11091816.

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Cytoglobin is a hexacoordinate hemoglobin with physiological roles that are not clearly understood. Previously proposed physiological functions include nitric oxide regulation, oxygen sensing, or/and protection against oxidative stress under hypoxic/ischemic conditions. Like many globins, cytoglobin rapidly consumes nitric oxide under normoxic conditions. Under hypoxia, cytoglobin generates nitric oxide, which is strongly modulated by the oxidation state of the cysteines. This gives a plausible role for this biochemistry in controlling nitric oxide homeostasis. Mutations to control specific properties of hemoglobin and myoglobin, including nitric oxide binding/scavenging and the nitrite reductase activity of various globins, have been reported. We have mapped these key mutations onto cytoglobin, which represents the E7 distal ligand, B2/E9 disulfide, and B10 heme pocket residues, and examined the nitric oxide binding, nitric oxide dioxygenase activity, and nitrite reductase activity. The Leu46Trp mutation decreases the nitric oxide dioxygenase activity > 10,000-fold over wild type, an effect 1000 times greater than similar mutations with other globins. By understanding how particular mutations can affect specific reactivities, these mutations may be used to target specific cytoglobin activities in cell or animal models to help understand the precise role(s) of cytoglobin under physiological and pathophysiological conditions.
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Sibgatullin, I. T., R. Ya Gilmutdinov e T. M. Zakirov. "The Effect of the Drug Estrofan on the Content of Nitric Oxide (II), Sex Hormones, Biochemical Parameters and Their Relationship in Cows". BIO Web of Conferences 37 (2021): 00170. http://dx.doi.org/10.1051/bioconf/20213700170.

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Abstract (sommario):
The physiological functions of nitric oxide (II) are diverse, and its therapeutic uses continue to expand. Many methods have been found to regulate the production of this compound, both physiological, regulated by the body itself, and as a result of various, drug and non-drug, external influences, correcting the ability of cells, organs and tissues to produce nitric oxide (II). The drug estrophan (synthetic prostaglandin PGF2α) has an activating effect on the nitric oxide (II) system and on sex hormones that regulate the reproductive functions of cows. The introduction of estrophan to cows is accompanied by an increase in the synthesis of nitric oxide (II), estrogen in the body of cows, and a decrease in progesterone. A high level of interrelation of estrogen with nitric oxide (II) was shown, the value of the correlation coefficient is (r = 0.552; p < 0.05). Correlation of the level of nitric oxide (II) with estrogen allows making an assumption of its bioregulatory functions, including the sexual cycle. The introduction of estrophan had no effect on the biochemical parameters in the blood serum of cows.
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Jovic, Slavoljub, Jelka Stevanovic, Suncica Borozan, Blagoje Dimitrijevic, Svetlana Fister e Jelena Aleksic. "Useful and harmful effects of nitric oxide". Veterinarski glasnik 67, n. 3-4 (2013): 245–57. http://dx.doi.org/10.2298/vetgl1304245j.

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Abstract (sommario):
In living sistems synthesis of nitric oxide occurs during metabolism from Larginin, nitrite and ascorbate. Being very significant carrier of information within numerous both physiological and pathological proceses in mammals' organisms, nitric oxid could possibly be useful as well as harmful. Nitric oxide synthesis is adjuvant in a healthy organism because it represents the basic molecule for understanding numerous processes in neurology, psychology, immunology and varios related fields. In other words, nitric oxide participate in number of physiological processes, such as: transmission of nerve signals (neurotransmitter role), regulation of smooth muscle tissue relaxation (eg. vasodilatation), peristaltic movements, immunomodulation, mastocyte activation, development of inflammatory response, apoptosis regulation, angiogenesis and glucose metabolism, normal heart functioning and antioxidation role. Besides being useful, nitric oxide can be harmful as well, because it has one unpaired electron, so consequently it is susceptible to oxidation becoming a stable free radical. Being such, it reacts quickly with superoxide-anion radical, givind at first an extremely reactive peroxinitrite anion, and subsequently peroxidnitrite acid. This acid is very dangerous causing thiol groups oxidation, tyrosine and phenylalanine nitrosylation, lipid oxidation, DNK chain splitting, nitrification and nucleic bases deamination. These damages of macromolecules can cause a series of undesirable changes which subsequently distub functions of molecules, and thus of cells, tissues and even organs.
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Muftin, Najlaa Qassim, Asma Jameil Al-Lamei, Suzanne Jubair, Abdalla Raied Jabber e Rasha Shakir Mahmood. "The Role Of Nitric Oxide In Cancer Development & it`s Therapy". Journal of advanced Sciences and Engineering Technologies 3, n. 1 (3 gennaio 2020): 21–34. http://dx.doi.org/10.32441/jaset.03.01.02.

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Abstract (sommario):
The Nitric oxide is a free radical belongs to reactive nitrogen species, acts as a signal molecule in many physiological and pathological processes as well as plays a significant role in a variety of biological processes including its action as a regulator to programmed cell death (apoptosis). In addition to its role in tumor formation, proliferation, and metastasis, Nitric oxide has also been stated to have tumoricidal effects. Therefore this review deals with the effect of nitric oxide on different types of cancer and its use in cancer drugs
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Suschek, Christoph V., Dennis Feibel, Maria von Kohout e Christian Opländer. "Enhancement of Nitric Oxide Bioavailability by Modulation of Cutaneous Nitric Oxide Stores". Biomedicines 10, n. 9 (29 agosto 2022): 2124. http://dx.doi.org/10.3390/biomedicines10092124.

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The generation of nitric oxide (NO) in the skin plays a critical role in wound healing and the response to several stimuli, such as UV exposure, heat, infection, and inflammation. Furthermore, in the human body, NO is involved in vascular homeostasis and the regulation of blood pressure. Physiologically, a family of enzymes termed nitric oxide synthases (NOS) generates NO. In addition, there are many methods of non-enzymatic/NOS-independent NO generation, e.g., the reduction of NO derivates (NODs) such as nitrite, nitrate, and nitrosylated proteins under certain conditions. The skin is the largest and heaviest human organ and contains a comparatively high concentration of these NODs; therefore, it represents a promising target for many therapeutic strategies for NO-dependent pathological conditions. In this review, we give an overview of how the cutaneous NOD stores can be targeted and modulated, leading to a further accumulation of NO-related compounds and/or the local and systemic release of bioactive NO, and eventually, NO-related physiological effects with a potential therapeutical use for diseases such as hypertension, disturbed microcirculation, impaired wound healing, and skin infections.
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Suresh, Vinod, David A. Shelley, Hye-Won Shin e Steven C. George. "Effect of heterogeneous ventilation and nitric oxide production on exhaled nitric oxide profiles". Journal of Applied Physiology 104, n. 6 (giugno 2008): 1743–52. http://dx.doi.org/10.1152/japplphysiol.01355.2007.

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Abstract (sommario):
Elevated exhaled nitric oxide (NO) in the breath of asthmatic subjects is thought to be a noninvasive marker of lung inflammation. Asthma is also characterized by heterogeneous bronchoconstriction and inflammation, which impact the spatial distribution of ventilation in the lungs. Since exhaled NO arises from both airway and alveolar regions, and its level in exhaled breath depends strongly on flow, spatial heterogeneity in flow patterns and NO production may significantly affect the exhaled NO signal. To investigate the effect of these factors on exhaled NO profiles, we developed a multicompartment mathematical model of NO exchange using a trumpet-shaped central airway segment that bifurcates into two similarly shaped peripheral airway segments, each of which empties into an alveolar compartment. Heterogeneity in flow alone has only a minimal impact on the exhaled NO profile. In contrast, placing 70% of the total airway NO production in the central compartment or the distal poorly ventilated compartment can significantly increase (35%) or decrease (−10%) the plateau concentration, respectively. Reduced ventilation of the peripheral and acinar regions of the lungs with concomitant elevated NO production delays the rise of NO during exhalation, resulting in a positive phase III slope and reduced plateau concentration (−11%). These features compare favorably with experimentally observed profiles in exercise-induced asthma and cannot be simulated with single-path models. We conclude that variability in ventilation and NO production in asthmatic subjects impacts the shape of the exhaled NO profile and thus impacts the physiological interpretation.
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Cui, X. M., Y. K. Zhang, X. B. Wu e C. S. Liu. "The investigation of the alleviated effect of copper toxicity by exogenous nitric oxide in tomato plants". Plant, Soil and Environment 56, No. 6 (3 giugno 2010): 274–81. http://dx.doi.org/10.17221/98/2009-pse.

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Abstract (sommario):
As a bioactive signal, nitric oxide (NO) is involved in multiple plant physiological responses, especially under some abiotic stress. Here, we investigated the effects of exogenous nitric oxide on both the reactive oxygen species (ROS) scavenging metabolism and regulating functions of plasma membrane and tonoplast in tomato plants treated with 50&micro;M CuCl<sub>2</sub>. Copper stress induced significant accumulation of H<sub>2</sub>O<sub>2</sub>, led to serious lipid peroxidation, and finally markedly decreased shoot height and fresh weight of tomato plants. The application of 100&micro;M sodium nitroprusside (SNP &ndash; NO donor) promoted some antioxidant enzymes, reduced accumulation of H<sub>2</sub>O<sub>2</sub>, and adjusted the activity of H<sup>+</sup>-ATPase and H<sup>+</sup>-PPase in plasma membrane or tonoplast, and significantly alleviated the growth inhibition induced by copper toxicity. On the other hand, the application of sodium ferrocyanide (an analog of SNP) and sodium nitrate or nitrite (the decomposition product of NO or its donor SNP) which did not release NO, did not show the effects of SNP. Furthermore, the effects of SNP were reverted by addition of hemoglobin (an NO scavenger). Therefore, these results indicated that exogenous NO could effectively assuage copper toxicity by physiological and biochemical response so as to maintain normal growth. &nbsp;
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Nenasheva, N. M., e N. M. Nenasheva. "ROLE OF NITRIC OXIDE IN EXHALED AIR IN BRONCHIALASTHMA". Russian Journal of Allergy 7, n. 1 (15 marzo 2010): 26–31. http://dx.doi.org/10.36691/rja871.

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In this review the main physiological effects of nitric oxide in the human body have been considered, as well as its pathophysiologic role in bronchial asthma. Methods for determination of nitric oxide in exhaled air have been described. The importance of determining the level of nitric oxide in patients with bronchial asthma has been analyzed.
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Satoh, Nobuhiko, Motonobu Nakamura, Atsushi Suzuki, Hiroyuki Tsukada, Shoko Horita, Masashi Suzuki, Kyoji Moriya e George Seki. "Effects of Nitric Oxide on Renal Proximal Tubular Na+Transport". BioMed Research International 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/6871081.

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Nitric oxide (NO) has a wide variety of physiological functions in the kidney. Besides the regulatory effects in intrarenal haemodynamics and glomerular microcirculation,in vivostudies reported the diuretic and natriuretic effects of NO. However, opposite results showing the stimulatory effect of NO on Na+reabsorption in the proximal tubule led to an intense debate on its physiological roles. Animal studies have showed the biphasic effect of angiotensin II (Ang II) and the overall inhibitory effect of NO on the activity of proximal tubular Na+transporters, the apical Na+/H+exchanger isoform 3, basolateral Na+/K+ATPase, and the Na+/HCO3-cotransporter. However, whether these effects could be reproduced in humans remained unclear. Notably, our recent functional analysis of isolated proximal tubules demonstrated that Ang II dose-dependently stimulated human proximal tubular Na+transport through the NO/guanosine 3′,5′-cyclic monophosphate (cGMP) pathway, confirming the human-specific regulation of proximal tubular transport via NO and Ang II. Of particular importance for this newly identified pathway is its possibility of being a human-specific therapeutic target for hypertension. In this review, we focus on NO-mediated regulation of proximal tubular Na+transport, with emphasis on the interaction with individual Na+transporters and the crosstalk with Ang II signalling.
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Tesi sul tema "Nitric oxide – Physiological effect"

1

Osborne, Michael G. "The role of nitric oxide in carrageenan-induced hyperalgesia". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0025/MQ50848.pdf.

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張婓怡 e Filly Cheung. "Regulation of nitric oxide synthase expression in mammalian cells". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31241554.

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Lee, Hing-lun, e 李慶麟. "Hemodynamic effects of endothelin-1 and platelet-activating factor after nitric oxide synthase inhibition in the rat". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31969628.

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Morakinyo, Moshood Kayode. "S-Nitrosothiols: Formation, Decomposition, Reactivity and Possible Physiological Effects". PDXScholar, 2010. https://pdxscholar.library.pdx.edu/open_access_etds/100.

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Abstract (sommario):
Three biologically-active aminothiols cysteamine (CA), DL-cysteine (CYSH) and DL-homocysteine, were studied in this thesis. These aminothiols react with nitrous acid (HNO2), prepared in situ, to produce S-nitrosothiols (RSNOs): S-nitrosocyteamine (CANO), S-nitrosocysteine (CYSNO) and S-nitrosohomocysteine (HCYSNO). They also react with S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP) through a transnitrosation reaction to produce their corresponding RSNOs. A detailed kinetics and mechanistic study on the formation of these RSNOs and their subsequent decomposition to release nitric oxide (NO) were studied. For all three aminothiols the stoichiometry of their reaction with nitrous acid is strictly 1:1 with the formation of one mole of RSNO from one mole of HNO2. In all cases, the nitrosation reaction is first order in nitrous acid, thus implicating it as a nitrosating agent in mildly acidic pH conditions. Acid catalyzes nitrosation after nitrous acid has saturated, implicating another nitrosating agent, the nitrosonium cation, NO+ ( which is produced from the protonation of nitrous acid) as a contributing nitrosating species in highly acidic environments. The acid catalysis at constant nitrous acid concentrations suggests that the nitrosonium cation nitrosates at a much higher rate than nitrous acid. Nitric oxide itself was not detected as a nitrosant. Bimolecular rate constants for the nitrosation of CA, CYSH and HCYSH were deduced to be 17.9, 6.4, 0.09 M-1 s-1 for the nitrosation by nitrous acid and 8.25 x 1010, 2.89 x 1010 and 6.57 x 1010 M-1 s-1 for the nitrosation by nitrosonium cation respectively. A linear correlation was obtained between the rate constants and the pKa of the sulfur center of the aminothiols for nitrosation by NO+. The stabilities of the three RSNOs were found to be affected by metal ions. They were unstable in the presence of metal ions, with half-lives of few seconds. However, in the presence of metal ion chelators, they were found to be relatively stable with half-lives of 10, 30 and 198 hours for CYSNO, CANO and HCYSNO respectively. The relative stability of HCYSNO may be an advantage in the prevention of its metabolic conversion to homocysteine thiolactone, the major culprit in HCYSH pathogenesis. This dissertation has thus revealed new potential therapeutic way for the modulation of HCYSH related cardiovascular diseases.
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McLean, David L. "The gaseous messenger molecule, nitric oxide : a modulator of locomotor movements during early amphibian development". Thesis, University of St Andrews, 2001. http://hdl.handle.net/10023/2829.

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Abstract (sommario):
1. The free radical gas nitric oxide (NO) is now recognised as a ubiquitous and versatile signalling molecule and the investigation of its biological roles has involved a wide range of scientific disciplines in many different species. Yet despite this, its potential roles in the development of rhythmic motor activities in vertebrates have been largely ignored. 2. Physiological experiments recording extracellular ventral root output suggest that NO is playing an inhibitory role in the swimming system of Xenopus laevis larvae, shortening the duration of swim episodes and slowing swim frequency. Nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase histochemistry labelled three populations of neurons in the brainstem, which putatively co-localise NO with the aminergic neuromodulators serotonin (5-HT) and noradranaline (NA), and the fast descending inhibitory neurotransmitter, y-aminobutyric acid (GABA). This suggests that the inhibitory role is supraspinal in origin. 3. Intracellular recordings from neurons presumed to be spinal motor neurons provide further evidence for the inhibitory influence of NO. My experiments suggest that NO potentiates both glycinergic and y-aminobutyric acid (GABA)-ergic inhibition onto spinal motor neurons. The facilitation of the release of these inhibitory transmitters is consistent with the observed effects on swim frequency and swim episode duration, respectively. Additionally, NO appears to affect membrane properties, causing a pronounced membrane potential depolarisation and a decrease in membrane conductance. This suggests that NO shuts off a resting membrane conductance. 4. NADPH-diaphorase histochemistry was subsequently applied to determine the four dimensional expression of putative nitrergic neurons in the central nervous system and related structures. The developmental sequence of staining identifies groups and subgroups of interconnected intemeurons, and provides further clues to their identity. NADPH-diaphorase labelling was also located in the eyes, skin and blood vessels, further confirming the validity of this staining technique for identirying nitric oxide synthase. 5. In the related anuran species, Rana temporaria nitric oxide donor drugs appear to have no affect on swimming, but instead reliably initiates a non-rhythmic "lashing" motor pattern similar to that elicited by dimming of the illumination. Interestingly the NADPH-diaphorase technique labelled three clusters of apparently homologous interneurons in the brainstem and additionally the inner layer of the skin was intensely stained, implicating a species-specific role for NO released from brainstem neurons.
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許煥珍 e Wun-chun Hui. "A study on the potential effects of endogenous nitric oxide in the healing of acetic acid-induced gastric ulcer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B42575928.

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Heaton, Daniel Anthony. "Role of nNOS in the autonomic control of cardiac excitability in cardiac physiological and pathophysiological states". Thesis, University of Oxford, 2005. http://ora.ox.ac.uk/objects/uuid:5dfc213d-7846-485d-93f1-1635a0018ef0.

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何志達 e Chi-tat Ho. "Nitric oxide and bone morphogenetic protein -2, 4 and 7 expressions during cleft palate formation in BALB/c mice". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31970217.

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Xu, Mingjing, e 徐明婧. "Baicalin protects neural cells from cerebral ischemia reperfusion injury by scavenging peroxynitrite". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47753110.

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Abstract (sommario):
 Ischemic stroke is the leading cause of death and disability in human diseases all around the world. As effective treatment for ischemic stroke is still absent, seeking for new therapy is of great interest. Currently, several key pathological cascades following cerebral ischemia have been explored to develop further therapies. Among them, reactive nitrogen species (RNS) has been indicated to play a critical role in cerebral ischemia reperfusion injury. As one of the RNS, peroxynitrite contributes to the neural cell death and subsequent brain dysfunction in the process. Thus, development of antioxidants targeting on peroxynitrite could be an important strategy for the treatment of cerebral ischemia-reperfusion injury. Baicalin is a polyphenolic compound isolated from roots of Scutellaria baicalensis. Baicalin exerted protective effects against cerebral ischemia-reperfusion injury but the mechanisms are not clear yet. In this study, we investigated the free radical scavenging ability and neuroprotective effects of baicalin. According to our results, baicalin neutralized DPPH radicals effectively. By using electron paramagnetic resonance (EPR) spin trapping technology and fluorescent probe DAF-2DA, we found that baicalin dose-dependently scavenged superoxide, but had very low effect on elimination of nitric oxide. The immunofluoresent results revealed that baicalin at the concentration of 50 M completely suppressed the nitrotyrosine formation induced by 3-morpholinylsydnoneimine chloride (SIN-1, a peroxynitrite donor) in neuroblastoma SH-SY5Y cells. Mass spetrum provided direct evidence of the peroxynitrite scavenging ability of baicalin. Using MTT assays, we found that baicalin totally reversed peroxynitrite-induced cytotoxicity in SH-SY5Y cells and protected SH-SY5Y cells in oxygen glucose deprivation (OGD) and following reoxygenation injury. Furthermore, in vivo experiments revealed that intravenous injection of baicalin exerted better neuroprotective effect than intraperitoneal administration in rats underwent middle cerebral artery occlusion (MCAO). After cerebral ischemia reperfusion, rats treated with 3 mg/kg of peroxynitrite decomposition catalyst (FeTMPyP) or 25 mg/kg of baicalin revealed a smaller size of infarction volume, suppressed neural cell death and reduced nitrotyrosine formation than MCAO rats. However, baicalin did not alter the expression of tight junction proteins, claudin-5 and ZO-1, in brain endothelial bEnd3 cell line treated with OGD following reoxygenation. In cerebral ischemia reperfusion rats, administration of FeTMPyP at the dosage of 3 mg/kg diminished the Evans blue leakage caused by blood brain barrier disruption, whereas treatment of baicalin did not show significant effect. In conclusion, this study suggests that baicalin can scavenge peroxynitrite and protect neural cells from peroxynitrite-induced injury. Furthermore, baicalin could prevent brains from cerebral ischemia-reperfusion injury and the neuroprotective mechanisms are associated with the scavenging effects on peroxynitrite. These findings provide new insights into the antioxidant and neuroprotective properties of baicalin and indicate the potential application of baicalin for the treatment of ischemic stroke.
published_or_final_version
Chinese Medicine
Master
Master of Philosophy
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Davis, John Paul. "Acute and chronic effects of nitric oxide on cardiomyocyte guanylyl cyclase, implications for the modulation of the heart following environmental, physiological and clinical exposure to nitric oxide". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0015/NQ37880.pdf.

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Libri sul tema "Nitric oxide – Physiological effect"

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service), ScienceDirect (Online, a cura di. Nitric oxide. San Diego, Calif: Elsevier/Academic Press, 2008.

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Dimmeler, Stefanie. Nitric oxide-stimulated ADP-ribosylation. Aachen: Shaker, 1993.

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3

Martin, Feelisch, e Stamler Jonathan S, a cura di. Methods in nitric oxide research. Chichester: J. Wiley, 1996.

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Ignarro, Louis J. Nitric oxide: Biology and pathobiology. 2a ed. Amsterdam: Boston, 2010.

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Hayat, Shamsul. Nitric oxide in plant physiology. Weinheim: Wiley-Blackwell, 2010.

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Aviv, Hassid, a cura di. Nitric oxide protocols. 2a ed. Totowa, N.J: Humana Press, 2004.

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Joseph, Loscalzo, e Vita Joseph A, a cura di. Nitric oxide and the cardiovascular system. Totowa, N.J: Humana Press, 2000.

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Nitric oxide: Methods and protocols. New York, N.Y: Humana Press, 2011.

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Rosslyn, Nicholson, a cura di. Life, death, and nitric oxide. Cambridge, UK: RSC, 2003.

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O, Cannon Richard, e Panza Julio A, a cura di. Endothelium, nitric oxide, and atherosclerosis. Armonk, NY: Futura Pub. Co., 1999.

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Capitoli di libri sul tema "Nitric oxide – Physiological effect"

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Garthwaite, J. "The Physiological Roles of Nitric Oxide in the Central Nervous System". In Nitric Oxide, 259–75. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-57077-3_12.

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Shen, Xinggui, Alan D. Kaye, Elyse M. Cornett e Christopher G. Kevil. "Nitric Oxide and Hemoglobin: Physiological Implications". In Blood Substitutes and Oxygen Biotherapeutics, 93–97. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-95975-3_9.

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Pfeilschifter, Josef, e Heiko Mühl. "NOS in Mesangial Cells: Physiological and Pathophysiological Roles". In Nitric Oxide and the Kidney, 198–215. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-6039-5_10.

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Siesjö, Peter. "Sensitizing Effect of Nitric Oxide to Cytotoxic Stimuli". In Nitric Oxide (NO) and Cancer, 237–52. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-1432-3_12.

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Adams, D. R., M. Brochwicz-Lewinski e A. R. Butler. "Nitric Oxide: Physiological Roles, Biosynthesis and Medical Uses". In Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, 1–186. Vienna: Springer Vienna, 1999. http://dx.doi.org/10.1007/978-3-7091-6351-1_1.

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Grisham, Matthew B., David Jourd’heuil e David A. Wink. "Physiological Chemistry of Superoxide and Nitric Oxide Interactions". In Advances in DNA Damage and Repair, 125–34. Boston, MA: Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4865-2_11.

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Nasir Khan, M., Mohammad Mobin e Zahid Khorshid Abbas. "Nitric Oxide and High Temperature Stress: A Physiological Perspective". In Nitric Oxide Action in Abiotic Stress Responses in Plants, 77–93. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-17804-2_5.

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Bajguz, Andrzej. "Nitric Oxide: Role in Plants Under Abiotic Stress". In Physiological Mechanisms and Adaptation Strategies in Plants Under Changing Environment, 137–59. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8600-8_5.

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Stamler, Jonathan S. "S-Nitrosothiols: Correlation of Biological Chemistry with Physiological Actions". In Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide, 67–78. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1903-4_7.

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Klasson, K. Thomas, e Brian H. Davison. "Effect of Temperature on Biofiltration of Nitric Oxide". In Twenty-Second Symposium on Biotechnology for Fuels and Chemicals, 205–11. Totowa, NJ: Humana Press, 2001. http://dx.doi.org/10.1007/978-1-4612-0217-2_18.

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Atti di convegni sul tema "Nitric oxide – Physiological effect"

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Tao Zhang, Rui-xueWang, Liang-yu Shen e Yan Zou. "Effect of exogenous nitric oxide on seed germination and physiological characteristics of Brassica napus". In 2011 International Conference on Remote Sensing, Environment and Transportation Engineering (RSETE). IEEE, 2011. http://dx.doi.org/10.1109/rsete.2011.5965601.

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Zeng Chang-li, Liu Min-chao e Luo Man. "Physiological effects of exogenous nitric oxide on Brassica campestris ssp. Chinensis L. seedlings under salt stress". In 2011 International Conference on Remote Sensing, Environment and Transportation Engineering (RSETE). IEEE, 2011. http://dx.doi.org/10.1109/rsete.2011.5965474.

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Svitko, S. O., K. S. Koroleva, G. F. Sitdikova e K. A. Petrova. "The role of nitric oxide in the regulation of the electrical activity of the trigeminal nerve in the rat". In VIII Vserossijskaja konferencija s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka». Publishing center of Ulyanovsk State University, 2021. http://dx.doi.org/10.34014/mpphe.2021-177-180.

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Abstract (sommario):
Nitric oxide (NO) is a gaseous signaling molecule that regulates a number of physiological functions, including its role in the formation of migraine has been established. NO is endogenously produced in the body from L-arginine by NO synthase. The NO donor, nitroglycerin, is a trigger of migraine in humans and is widely used in the modeling of this disease in animals, which suggests the involvement of components of the NO signaling cascade in the pathogenesis of migraine. Based on the results obtained, it was found that an increase in the concentration of both the substrate for the synthesis of NO, L-arginine, and the NO donor, sodium nitroprusside, has a pro-nociceptive effect in the afferents of the trigeminal nerve. In this case, the effect of sodium nitroprusside is associated with the activation of intracellular soluble guanylate cyclase. Key words: nitric oxide, migraine, trigeminal nerve, L-arginine, guanylate cyclase, sodium nitroprusside, nociception.
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Elshiekh, Duaa Ibnomer, Hadeel Hendawi, Aya Goul, Dina Awartan, Isra Marei, Christopher Triggle e Haissam Abou Saleh. "Effect of Hyperglycemia on eNOS function in EPCs". In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0215.

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Abstract (sommario):
Type 2 diabetes mullites (T2DM) results in different cardiovascular complications. The main cause of these complications is endothelial dysfunction, which affects the endothelium physiologically and pathologically. The chronic hyperglycemia introduced by T2DM impacts the pivotal enzyme endothelial nitric oxide synthase (eNOS) in terms of phosphorylation and dimerization, which initiates oxidative stress and reduces the bioavailability of the vasodilator nitric oxide. To overcome endothelial dysfunction, endothelial progenitor cells (EPCs) contribute to vascular repair due to their regenerative characteristics. The effects of hyperglycemia on EPCs are understudied. Thus, this study aims to investigate the effects of hyperglycemia on the eNOS/Akt signaling pathway and reactive oxygen species (ROS) formation. Cells were treated with normal glucose (NG, 5.5mM) and high glucose (HG, 25mM) media for 3 & 6 days, and the effect on eNOS and Akt phosphorylation were assessed using western blot. ROS was assessed using CellROX stain following 1 and 3 days of treatment. Results showed that both acute and chronic hyperglycemia showed a trend towards decrease in phosphorylation of eNOS and Akt. In addition, ROS formation was increased following 24hr compared to NG. Further investigations are needed to enhance the capability of BOECs to serve as therapeutic tools in T2DM.
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Forsyth, Alison M., Philip D. Owrutsky, Jiandi Wan e Howard A. Stone. "Channel Geometry Effects on Red Blood Cell Dynamics and the Resulting ATP Release". In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19359.

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Abstract (sommario):
In shear flow, red blood cells (RBCs) exhibit a variety of dynamic behaviors such as translation, tumbling, swinging, and tank-treading. The physiological consequences of these dynamic behaviors, however, are unknown. For example, how different cell dynamics, be it translation, tumbling, or tank-treading relate to ATP release and how these dynamics are altered by pathological geometries such as constrictions and plaque formations at asymmetric bifurcations are not known. Using microfluidic channels to mimic pathological geometries and RBCs with attached carboxylate beads, to follow any relevant motion, we are able to quantify the dynamical response of red cells to specific pathological geometries with in vitro models. Further, by using an ATP-luciferase enzymatic reaction we set out to determine if there is a functional difference, via chemical release, in cell behaviors. Previously, we correlated RBC deformation and ATP release (Wan et al, PNAS 2008) which in vivo is known to stimulate nitric oxide production, leading to vasodilation. High-speed video and a probability-based cell tracking algorithm make it possible to study large numbers of cells. Preliminary experiments have shown that when cells enter a constriction, there are increased instances of tumbling along constriction wall, while cells more central in the constriction are aligned and deformed by the entrance flow. The relation between the observed cell behaviors and resulting ATP release will be reported.
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Chazan, David, Vivek Balasubramanyam, Bhairavi Parikh e Nina Peled. "The Effect Of Ambient Nitric Oxide On Exhaled Nitric Oxide Measurements". In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4272.

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Wilson, John T., Rebecca L. Dahlin, Olga Gasheva, David C. Zawieja e James E. Moore. "Nitric Oxide Transport in Lymphatic Vessels". In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53886.

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Abstract (sommario):
The lymphatic system plays a vital role in maintaining proper physiological function in the body. Its removal of proteins and other particulate matter from the tissue spaces is particularly important for the body’s prevention of extracellular edema [1]. After fluid is absorbed by the initial lymphatics, it is transported to lymph nodes where filtration occurs. In addition, the lymphatic system serves as a common pathway of initial metastases to regional lymph nodes for certain types of cancers [2]. Thus, the characterization of mass transport in the lymphatic system could lead to unprecedented insight into the treatment of such pathologies.
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Shibata, Masahiro, Takehiro Yamakoshi e Ken-ichi Yamakoshi. "Physiological role of nitric oxide in oxygen consumption by arteriolar wall". In 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2008. http://dx.doi.org/10.1109/iembs.2008.4649424.

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Zhang, Xiaoling, Qiao Yang, Yunhua Hui, Youqiong Cai, Wuzhong Ni e Huijuan Yu. "Physiological Functions of Nitric Oxide in Sedum Alfredii Hance under Complex Heavy Metals Stress". In 2009 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2009. http://dx.doi.org/10.1109/icbbe.2009.5163192.

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Karampitsakos, Theodoros, Adonis Protopapas, Maria Gianoloudi, Athanasios Chatzimichail e Emmanouil Paraskakis. "The effect of bronchodilation and spirometry on exhaled nitric oxide". In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa3356.

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Rapporti di organizzazioni sul tema "Nitric oxide – Physiological effect"

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Zhou, Youfa, Yanting Zhang, Jing Zhao e Gang Chen. The effect of Nitric oxide delivered via cardiopulmonary bypass on postoperative outcomes in patients who underwent cardiac surgery: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, dicembre 2022. http://dx.doi.org/10.37766/inplasy2022.12.0002.

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Schwartz, Bertha, Vaclav Vetvicka, Ofer Danai e Yitzhak Hadar. Increasing the value of mushrooms as functional foods: induction of alpha and beta glucan content via novel cultivation methods. United States Department of Agriculture, gennaio 2015. http://dx.doi.org/10.32747/2015.7600033.bard.

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Abstract (sommario):
During the granting period, we performed the following projects: Firstly, we differentially measured glucan content in several pleurotus mushroom strains. Mushroom polysaccharides are edible polymers that have numerous reported biological functions; the most common effects are attributed to β-glucans. In recent years, it became apparent that the less abundant α-glucans also possess potent effects in various health conditions. In our first study, we explored several Pleurotus species for their total, β and α-glucan content. Pleurotuseryngii was found to have the highest total glucan concentrations and the highest α-glucans proportion. We also found that the stalks (stipe) of the fruit body contained higher glucan content then the caps (pileus). Since mushrooms respond markedly to changes in environmental and growth conditions, we developed cultivation methods aiming to increase the levels of α and β-glucans. Using olive mill solid waste (OMSW) from three-phase olive mills in the cultivation substrate. We were able to enrich the levels mainly of α-glucans. Maximal total glucan concentrations were enhanced up to twice when the growth substrate contained 80% of OMSW compared to no OMSW. Taking together this study demonstrate that Pleurotuseryngii can serve as a potential rich source of glucans for nutritional and medicinal applications and that glucan content in mushroom fruiting bodies can be further enriched by applying OMSW into the cultivation substrate. We then compared the immune-modulating activity of glucans extracted from P. ostreatus and P. eryngii on phagocytosis of peripheral blood neutrophils, and superoxide release from HL-60 cells. The results suggest that the anti-inflammatory properties of these glucans are partially mediated through modulation of neutrophileffector functions (P. eryngiiwas more effective). Additionally, both glucans dose-dependently competed for the anti-Dectin-1 and anti-CR3 antibody binding. We then tested the putative anti-inflammatory effects of the extracted glucans in inflammatory bowel disease (IBD) using the dextran sulfate sodium (DSS)–induced model in mice. The clinical symptoms of IBD were efficiently relieved by the treatment with two different doses of the glucan from both fungi. Glucan fractions, from either P. ostreatus or P. eryngii, markedly prevented TNF-α mediated inflammation in the DSS–induced inflamed intestine. These results suggest that there are variations in glucan preparations from different fungi in their anti-inflammatory ability. In our next study, we tested the effect of glucans on lipopolysaccharide (LPS)-induced production of TNF-α. We demonstrated that glucan extracts are more effective than mill mushroom preparations. Additionally, the effectiveness of stalk-derived glucans were slightly more pronounced than of caps. Cap and stalk glucans from mill or isolated glucan competed dose-dependently with anti-Dectin-and anti-CR-3 antibodies, indicating that they contain β-glucans recognized by these receptors. Using the dextran sulfate sodium (DSS)-inflammatory bowel disease mice model, intestinal inflammatory response to the mill preparations was measured and compared to extracted glucan fractions from caps and stalks. We found that mill and glucan extracts were very effective in downregulatingIFN-γ and MIP-2 levels and that stalk-derived preparations were more effective than from caps. The tested glucans were equally effective in regulating the number of CD14/CD16 monocytes and upregulating the levels of fecal-released IgA to almost normal levels. In conclusion, the most effective glucans in ameliorating some IBD-inflammatory associated symptoms induced by DSS treatment in mice were glucan extracts prepared from the stalk of P. eryngii. These spatial distinctions may be helpful in selecting more effective specific anti-inflammatory mushrooms-derived glucans. We additionally tested the effect of glucans on lipopolysaccharide-induced production of TNF-α, which demonstrated stalk-derived glucans were more effective than of caps-derived glucans. Isolated glucans competed with anti-Dectin-1 and anti-CR3 antibodies, indicating that they contain β-glucans recognized by these receptors. In conclusion, the most effective glucans in ameliorating IBD-associated symptoms induced by DSS treatment in mice were glucan extracts prepared from the stalk of P. eryngii grown at higher concentrations of OMSW. We conclude that these stress-induced growing conditions may be helpful in selecting more effective glucans derived from edible mushrooms. Based on the findings that we could enhance glucan content in Pleurotuseryngii following cultivation of the mushrooms on a substrate containing different concentrations of olive mill solid waste (OMSW) and that these changes are directly related to the content of OMSW in the growing substrate we tested the extracted glucans in several models. Using dextran sulfate sodium (DSS)–inflammatory bowel disease (IBD) mice model, we measured the colonic inflammatory response to the different glucan preparations. We found that the histology damaging score (HDS) resulting from DSS treatment reach a value of 11.8 ± 2.3 were efficiently downregulated by treatment with the fungal extracted glucans, glucans extracted from stalks cultivated at 20% OMSWdownregulated to a HDS value of 6.4 ± 0.5 and at 80% OMSW showed the strongest effects (5.5 ± 0.6). Similar downregulatory effects were obtained for expression of various intestinal cytokines. All tested glucans were equally effective in regulating the number of CD14/CD16 monocytes from 18.2 ± 2.7 % for DSS to 6.4 ± 2.0 for DSS +glucans extracted from stalks cultivated at 50% OMSW. We finally tested glucans extracted from Pleurotuseryngii grown on a substrate containing increasing concentrations of olive mill solid waste (OMSW) contain greater glucan concentrations as a function of OMSW content. Treatment of rat Intestinal epithelial cells (IEC-6) transiently transfected with Nf-κB fused to luciferase demonstrated that glucans extracted from P. eryngii stalks grown on 80% OMSWdownregulatedTNF-α activation. Glucans from mushrooms grown on 80% OMSW exerted the most significant reducing activity of nitric oxide production in lipopolysaccharide (LPS) treated J774A.1 murine macrophages. The isolated glucans were tested in vivo using the Dextran Sodium Sulfate (DSS) induced colitis in C57Bl/6 mice and found to reduce the histology damaging score resulting from DSS treatment. Expression of various intestinal cytokines were efficiently downregulated by treatment with the fungal extracted glucans. We conclude that the stress-induced growing conditions exerted by OMSW induces production of more effective anti-inflammatory glucans in P. eryngii stalks.
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