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Tesi sul tema "Neutrophils"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Gillis, Caitlin. "Neutrophils in IgG- and endotoxin-induced systemic inflammation : protective or pathological agents ?" Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066279/document.

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Les neutrophiles contribuent à l'inflammation protectrice et pathologique. Ce projet de thèse consiste à déterminer le rôle des neutrophiles dans des modèles d'inflammation systémique graves et potentiellement mortelles, induite par le lipopolysaccharide (LPS, endotoxémie) ou par des complexes immuns antigène-anticorps (anaphylaxie). L'anaphylaxie est une réaction allergique qui peut être IgE- et/ou IgG-dépendante. L’endotoxémie est un modèle pertinent de l'inflammation au cours de maladies graves. Pour étudier les neutrophiles in vivo, nous avons utilisé un nouveau modèle murin de neutropénie

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2

Garcia, Geoffrey. "Les NETs (Neutrophils Extracellular Traps) et les DNases au cours de la COVID-19." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0175.

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Au cours des infections, les polynucléaires neutrophiles libèrent des Neutrophil Extracellular Traps (NETs) pour capturer les agents pathogènes et les détruire. Les NETs; en coordination avec les plaquettes et les cellules immunitaires, activent la coagulation et participent à l’immunothrombose pour piéger les agents pathogènes et éviter leur dissémination. Ils sont dégradés physiologiquement par les DNases et les macrophages. Exacerbée, les NETs sont responsables de dommages cellulaires et tissulaires. Ils sont décrits comme des acteurs centraux de nombreuses pathologies, notamment comme part

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3

Mawhin, Marie-Anne. "Role of neutrophils and leukotrienes in atherosclerotic plaque destabilisation : implication of endotoxemia." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ034/document.

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La déstabilisation de la plaque d’athérosclérose reste de nos jours un problème majeur, malgré les progrès récents dans sa compréhension. Les neutrophiles sont des acteurs puissants de l’immunité innée capables d’altérer les plaques. Un chimio-attractant majeur des neutrophiles, le leucotriène B4, pourrait être un des contributeurs potentiels de la déstabilisation des plaques en particulier dans l’endotoxémie, elle-même associée aux accidents cardiovasculaires. L’objectif de ce travail a été de définir le rôle du leucotriène B4 dans l’attraction des neutrophiles dans la plaque au cours de l’en

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4

Yao, Yi. "Sequential Priming of Neutrophils." University of Toledo Health Science Campus / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1389612809.

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5

Manriquez, Rojas Valeria. "Role of the innate immune response in vascular damage caused by Neisseria meningitidis infection Vascular colonization by Neisseria meningitidis triggers a delayed and inefficient neutrophil response Intermittent pili-mediated forces fluidize Neisseria meningitidis aggregates promoting vascular colonization Adhesion to nanofibers drives cell membrane remodeling through 1D wetting." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB076.

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Neisseria meningitidis est un diplocoque à Gram négatif responsable de méningite et de choc septique. Alors que la méningite est la forme d'infection la plus fréquente, la septicémie fulminante est responsable de 90% de la mortalité imputable à N. meningitidis. La septicémie méningococcique est caractérisée par une éruption purpurique due à des lésions vasculaires. Les observations au niveau histologique révèlent des méningocoques associés aux cellules endothéliales, des thromboses, des hémorragies périvasculaires et des infiltrations de cellules inflammatoires. Les mécanismes conduisant à ces

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6

Fischer, Steven Harold. "Interactions of Neisseria gonorrhoeae with human neutrophils: Gonococcal outer membrane protein II modulates neutrophil responses." Diss., The University of Arizona, 1988. http://hdl.handle.net/10150/184364.

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The disease gonorrhea has plagued mankind at least as long as written records have been kept (Black and Sparling, 1985). N. gonorrhoeae is still an important cause of suffering, infertility, and occasional mortality despite the fact that treatment with antibiotics is relatively easy and highly effective, even with the recent increase in penicillin-resistant isolates (Jephcott, 1986). The continued existence of this public health problem is partly the result of a reservoir of asymptomatic carriers within the community who normally don't seek treatment and continue their usual sexual practices (

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7

GRIMOLIZZI, FRANCO. "Neutrophils alter placental glucose metabolism in gestational diabetes mellitus via neutrophil elastase mediated IRS1 degradation." Doctoral thesis, Università Politecnica delle Marche, 2017. http://hdl.handle.net/11566/245194.

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La gravidanza è da considerarsi una condizione pro-inflammatoria dove si osserva un’attivazione dei neutrofili circolanti. Con l'avanzare della gravidanza la concentrazione nel sangue di nucleosomi e mieloperossidasi aumenta e riflette la produzione delle trappole extracellulari dei neutrofili (NETs). Abbiamo dimostrato che in corso di diabete mellito gestazionale (GDM) tale produzione è aumentata in confronto ad una gravidanza fisiologica. Elevati livelli di glucosio e TNF-a, segni tipici presenti in corso di GDM, in vitro agiscono in modo sinergico e sono in grado di pre-attivare i neutrof

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8

Darbousset, Roxane. "Roles of polymorphonuclear neutrophils in thrombosis." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5071.

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L’hémostase est un processus physiologique permettant de préserver l’intégrité du système vasculaire et de prévenir une perte de sang en réponse à une blessure. En situation pathologique, comme dans le cas de cancers, d’infections ou de maladies cardiovasculaires, il peut y avoir activation de la cascade de coagulation entraînant la formation d’un thrombus.Dans cette étude, nous avons utilisé la microscopie intravitale dans un modèle de blessure au rayon laser pour comprendre les mécanismes cellulaires et moléculaires mis en jeu dans la formation d’un thrombus plaquettaire en conditions physio

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9

Haynes, Andrew Paul. "Metabolic abnormalities in uraemic neutrophils." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305133.

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10

Cross, Andrew. "Molecular properties of inflammatory neutrophils." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250467.

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11

MacLeod, Ronald. "Gene expression in human neutrophils." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317206.

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12

Savill, John Stewart. "Macrophage recognition of senescent neutrophils." Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47641.

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13

Liu, Li. "Complement and neutrophil activation on protein coated solid surfaces." Göteborg : Dept. of General and Marine Microbiology and Dept of medical Microbiology and Immunology, University of Göteborg, 1997. http://catalog.hathitrust.org/api/volumes/oclc/38986844.html.

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14

Bordignon, Milena. "Relationship between AOPP (Advanced Oxidation Protein Products) and bovine neutrophils "in vitro": AOPP production by neutrophils and AOPP effects on neutrophils ROS production and viability." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3422657.

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The aim of the present study was to evaluate the relationship between AOPP (Advanced oxidation protein products) and bovine neutrophils 'in vitro'. For this purpose AOPP were produced "in vitro" by oxidizing bovine serum albumin with HOCl (hypochlorous acid) and bovine neutrophils were isolated from whole blood of dairy cattles. AOPP-BSA were incubated with freshly isolated bovine neutrophils, unstimulated and stimulated with PMA a strong activator of the respiratory burst. Neutrophils ROS production and viability were measured by luminol-amplified chemiluminescence and by MTT and lactate dehy

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15

Koch, Crystal C. "Effects of azithromycin on human neutrophils." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ48018.pdf.

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16

Naylor, Emma J. "Interactions of neutrophils with Haemophilus influenzae." Thesis, University of Liverpool, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427016.

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17

Medeiros, Kyle Andrew. "Hypoxia and the activity of neutrophils." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12516.

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Thesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Polymorphonuclear leukocytes (neutrophils) play a major role in fighting off invading bacteria. They are the first of the inflammatory cells to migrate to sites of inflammation through a process known as chemota

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18

Lowe, David. "The roles of neutrophils in tuberculosis." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24828.

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This thesis explores the potential roles of neutrophils in the host response to tuberculosis. First, a review of literature identifies the capacity of neutrophils to phagocytose and kill mycobacteria as well as their ability to influence the development of acquired immune responses. The effect of HIV infection on neutrophil function is also explored. Novel assays are presented to assess phagocytosis of mycobacteria (flow cytometry) and restriction of mycobacterial metabolism (bio-luminescence) by human neutrophils. Subsequently neutrophil function is investigated in HIV-infected antiretroviral

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19

Wan, Shek-kong Thomas. "Neutrophil function tests in Chinese newborn infants." Hong Kong : University of Hong Kong, 1991. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13186292.

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20

McColl, Shaun Reuss. "Factors affecting the regulation of leukotriene production by neutrophils." Title page, contents and summary only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phm1288.pdf.

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21

Romanelli, Raquel G. "Activation of neutrophil collagenase in periodontitis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0022/MQ40756.pdf.

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22

Rigby, David Andrew. "Inflammation-induced migration of neutrophils across the lymphatic endothelium." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.561107.

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Abstract (sommario):

The lymphatic system provides a conduit for the trafficking of immune cells from the periphery to draining lymph nodes, both for constitutive immune surveillance and during inflammation. Thus, leucocyte migration into the lymphatics represents an important step in the initiation of a primary immune response, which occurs within lymph nodes. Traditionally, it has been considered that neutrophils are absent from the afferent lymph, having a finite lifespan in the periphery after extravasation from the blood. However, recent research has reported the presence of neutrophils in lymph nodes, in ani

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23

Laurans, Salomé. "Interactions neutrophiles-adénovirus : mécanismes moléculaires impliqués et rôle physiologique." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL030.

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Les polynucléaires neutrophiles (PN) sont des cellules de l'immunité innée constituant, après les muqueuses et les épithéliums, la première ligne de défense contre les pathogènes. Si leur rôle est bien connu dans l'élimination des bactéries et champignons, leurs interactions avec les virus ont été moins étudiées. Lors d'infections virales, les PN peuvent être nécessaires à la résolution de l'infection (infections par le virus de l'herpès ou le virus de la grippe A) mais aussi, dans certains cas, excessivement recrutés et/ou activés générant ainsi d'importants dégâts aux tissus hôtes (virus res

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24

De, Chiara Alessia. "Molecular analysis of the prosurvival effect of cytosolic Proliferating Cell Nuclear Antigen (PCNA) in neutrophils." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05S002.

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Le polynucléaire neutrophile (PMN), cellule clé de l’immunité innée, est la première cellule à être recrutée sur le site inflammatoire. Après avoir détruit l’agent pathogène, il entre en apoptose puis est éliminé par les macrophages pour éviter le déversement de son contenu lytique, dangereux pour l’environnement. La régulation de la balance survie/apoptose du neutrophile est donc une étape cruciale de la résolution de l’inflammation. Notre laboratoire a mis en évidence la présence du Proliferating Cell Nuclear Antigen (PCNA) dans le neutrophile mature. PCNA est exprimé dans le noyau des cellu

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25

Lawson, Roderick A. "Neutrophils in bacterial pneumonia : influx and clearance." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/28407.

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A rabbit model of pneumonia was used. Bacteria were instilled bronchoscopically into a localised area, allowing strict timing of pneumonia onset, and study of subsequent evolving processes. Two organisms were used: 1) Streptococcus pneumoniae, an organism characteristic of pneumonia CAP and; 2) Escherichia coli, an organism characteristic of NP. It was hypothesised that in pneumonia due to the former (PneuS), the usual remarkably complete recovery witnessed clinically is due to the tissue load of neutrophils being carefully controlled. By contrast, pneumonia due to the latter (PneuE), is clini

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26

Brumell, John H. "Phosphorylation-dependent signalling mechanisms in human neutrophils." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0018/NQ27612.pdf.

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27

Reinhardt, P. Hans. "The function of VLA-4 on neutrophils." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0024/MQ31370.pdf.

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28

Perskvist, Nasrin. "Interaction between Mycobacterium tuberculosis and human neutrophils /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med679s.pdf.

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29

Harris, Fiona Elizabeth. "The role of neutrophils in experimental vasculitis." Thesis, St George's, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407971.

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30

Prigmore, Elena. "Rho family binding proteins in human neutrophils." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314081.

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31

Perry, Frances. "Oxidative responses of neutrophils to Streptococcus pneumoniae." Thesis, University of Bristol, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335509.

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32

Freitas, Marisa Andreia Carvalho de. "The Effect of Metals on Human Neutrophils." Doctoral thesis, Faculdade de Farmácia da Universidade do Porto, 2009. http://hdl.handle.net/10216/63815.

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33

Corleis, Bjoern. "Interaction of human neutrophils with mycobacterium tuberculosis." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549780.

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34

Cropp, Amy Rena. "Interaction of Bovine Seminal Proteins with Neutrophils." Thesis, The University of Arizona, 2006. http://hdl.handle.net/10150/193318.

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Abstract (sommario):

Neutrophils ordinarily infiltrate the female reproductive tract subsequent to mating or artificial insemination, resulting in reduced fertility. Recently, it was demonstrated that equine neutrophil extracellular traps (NETs) entangled sperm in these DNA-rich structures, interfering with their normal transport through the female reproductive tract. Seminal plasma (SP) or proteinaceous extracts from SP inhibited sperm-neutrophil binding and specifically degraded sperm-activated NETs, without suppressing bactericidal activity of neutrophils. Fertility-associated antigen (FAA), a 31 kDa natural

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35

Laight, David W. "Neutrophils and vascular reactivity in ischaemia/reperfusion." Thesis, University of Bath, 1994. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385291.

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36

Freitas, Marisa Andreia Carvalho de. "The Effect of Metals on Human Neutrophils." Tese, Faculdade de Farmácia da Universidade do Porto, 2009. http://hdl.handle.net/10216/63815.

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37

Kalupov, Timofey. "Protéases à serine du neutrophile et inflammations pulmonaires : 1. L’air exhalé condensé est-il un matériel adapté pour les mesures d’activités protéolytiques ? : 2. La spécificité des protéases neutrophiliques valide-t-elle l’utilisation du modèle souris de Broncho-Pneumopathie Chronique Obstructive (BPCO) ?" Thesis, Tours, 2009. http://www.theses.fr/2009TOUR3301/document.

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Abstract (sommario):

Le recrutement des neutrophiles qui caractérise l’inflammation observée lors de différentes pathologies pulmonaires conduit à la libération dans le milieu extracellulaire de protéases à sérine qui sont en partie responsables de la dégradation du tissu pulmonaire et/ou de la chronicité de l’inflammation. L’objectif initial de cette thèse était de développer une méthode de quantification de ces protéases, à partir des condensats d’air exhalé. En dépit de la sensibilité de la technique nous n’avons pas été en mesure de détecter des quantités significatives de protéases actives dans ces condensats

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38

Schroder, Angie Lisa. "A Role for Neutrophil Extracellular Traps in the Pathogenesis of Inflammatory Bowel Disease." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/28779.

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Neutrophil influx is a distinctive feature of inflammatory bowel disease (IBD), correlated with disease severity. Formation of neutrophil extracellular traps (NETs) is mediated by enzymes neutrophil elastase (NE), and myeloperoxidase (MPO) and its product hypochlorous acid (HOCl). Release of MPO in NETs results in extracellular HOCl production, causing tissue damage. To investigate NET formation in clinical IBD, ileal biopsies were retrieved from Crohn’s disease (CD) patients, allocated an endoscopic assignment of healthy, transitional or diseased, and corresponding histopathological score. A

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39

Koehl, Bérengère. "Implication de l'endotheline-1 dans l'adhérence et l'activation des polynucléaires neutrophiles dans la drépanocytose." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC112/document.

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La drépanocytose est une maladie génétique du globule rouge, due à une mutation ponctuelle du gène β de la chaine de l’hémoglobine. Néanmoins, la physiopathologie de la maladie va bien au-delà des anomalies érythrocytaires, avec notamment un dysfonctionnement vasculaire et leucocytaire qui font toute la complexité de la maladie. Au cours de ce travail, nous avons étudié le rôle de l’endothéline-1, peptide vaso-constricteur impliqué de nombreuses pathologies notamment vasculaires, sur l’activation et l’adhérence des polynucléaires neutrophiles dans la drépanocytose. Nous avons travaillé à la fo

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40

Tam, Wai-kin, and 譚偉健. "A small scale study evaluating allelic frequencies of human neutrophil antigens in Hong Kong Chinese population." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206588.

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Background: Human neutrophil antigens (HNA) are involved in a variety of clinical conditions such as transfusion related acute lung injury (TRALI), alloimmune neutropenia (ANN), autoimmune neutropenia (AIN). There are a total of five HNA systems, namely HNA-1, HNA-2, HNA-3, HNA-4 and HNA-5. In this decade, the allelic and genotypic frequencies of HNA were gradually evaluated in Europe, America and East Asia. [1] Despite HNA system being less polymorphic than HLA antigens, genotypic and allelic frequencies differences can still be observed in different geographical locations even of close pro

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41

Summers, Charlotte. "Neutrophil priming : effects on pulmonary transit time and bio-distribution in vivo." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609579.

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42

ROCK, JOHN PATRICK. "MOLECULAR BIOLOGY OF GONOCOCCAL DEATH FOLLOWING EXPOSURE TO THE GRANULE EXTRACTS OF HUMAN NEUTROPHILS (NEISSERIA GONORRHOEAE, PEPTIDOGLYCAN, MEMBRANE DAMAGE)." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183844.

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Gonococci that have been phagocytized by human neutrophils are killed very effectively. While much research has focused on defining the microbicidal mechanisms of the neutrophil arsenal, substantially less is known regarding why phagocytized bacteria die. Gonococci were examined, at the molecular level, following exposure to human neutrophil granule extracts (GE) in an effort to discover the "lethal lesion", that injury to the bacterial cell which results in its death. The cytoplasm-based metabolism of GE-treated gonococci continues to function normally for at least 30 minutes, although these

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43

Ishak, Reezal. "Calpain-1 : investigating its role in murine neutrophils." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/37448/.

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Abstract (sommario):

Neutrophils are phagocytic white blood cells which act as the first line of defence against entry of foreign microorganisms. Neutrophils are recruited to their target site through the process of spreading, extravasation and phagocytosis involving complex signal transduction within the cells, which might include the activation of the cytosolic Ca2+ activated protease, calpain-1. The work described here investigates the role of calpain-1 in regulating neutrophil functions such as spreading, trans-endothelial migration, chemotaxis, phagocytosis and Ca2+ signalling. Through the work done at Europe

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44

Morton, Jonathan. "Modulation of vascular tone by neutrophils in vivo." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/55681/.

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The vascular endothelium regulates vasomotor tone and blood fluidity through the release of paracrine factors, such as nitric oxide (NO). Acutely activated neutrophils have been shown to consume vasodilatory NO in vitro through the NAD(P)H oxidase-dependent generation of superoxide. As such, neutrophils may contribute to the endothelial dysfunction and increased vascular tone commonly observed in inflammatory vascular diseases. Herein, the experiments in this thesis set out to examine a role for neutrophils in the regulation of vascular tone. Initial experiments aimed to assess the capacity of

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45

Adams, Susan. "Activated gene expression by neutrophils in rheumatoid arthritis." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386829.

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46

Stringer, Rebecca Elizabeth. "Endogenous and activated protein synthesis in human neutrophils." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386847.

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47

Ellis, J. A. "Studies of the NADPH-oxidase of human neutrophils." Thesis, University of Bristol, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233765.

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48

Rodriguez, Jairo Antonio. "Functional activities of C-reactive protein on neutrophils." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2004. http://researchonline.lshtm.ac.uk/682313/.

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C-reactive protein (CRP) is a member of the pentraxin family which opsonises S. pneumoniae through its binding to phosphorylcholine. In addition, CRP binds to Fcγ receptors: FcγRI with high affinity and, probably, FcγRIIA with lower affinity. Binding to FcγRIIA was suggested to depend on a polymorphism at residue 131 of the receptor, HH individuals being poorer binders compared to RR. To clarify the role of CRP binding to FcγRIIA and functional activities upon interaction, neutrophils from HH and RR individuals were incubated with CRP in the presence or absence of pneumococci type 3. No differ

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49

Rowe, John Christopher. "Targeting Neutrophils to Improve Protection by Sublingual Vaccines." The Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1612190976457585.

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Lingadahalli, Shreyas Vaman. "ACTIVATED NEUTROPHILS MEDIATE KIM-1 SHEDDING AND RENALREMODELLING." Cleveland State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=csu1368404728.

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Gli stili APA, Harvard, Vancouver, ISO e altri

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