Letteratura scientifica selezionata sul tema "NBEAL2"
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Articoli di riviste sul tema "NBEAL2":
Noetzli, Leila, Natalie Smith, Gary Brodsky e Jorge Di Paola. "Expression Patterns Of NBEAL2 In Human Tissues and a Megakaryocytic Cell Line". Blood 122, n. 21 (15 novembre 2013): 1075. http://dx.doi.org/10.1182/blood.v122.21.1075.1075.
Lo, Richard W., Ling Li, Fred G. Pluthero, Richard Leung, Koji Eto e Walter H. A. Kahr. "The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis". Blood 136, n. 6 (6 agosto 2020): 715–25. http://dx.doi.org/10.1182/blood.2019004276.
Kahr, Walter H. A., Richard W. Lo, Ling Li, Fred G. Pluthero, Hilary Christensen, Ran Ni, Nima Vaezzadeh et al. "Abnormal megakaryocyte development and platelet function in Nbeal2−/− mice". Blood 122, n. 19 (7 novembre 2013): 3349–58. http://dx.doi.org/10.1182/blood-2013-04-499491.
Darling, Thayer K., Michael P. Schenk, Chengjing C. Zhou, Franklin M. Maloba, Patrice N. Mimche, Jonathan M. Gibbins, Shawn M. Jobe e Tracey J. Lamb. "Platelet α-granules contribute to organ-specific pathologies in a mouse model of severe malaria". Blood Advances 4, n. 1 (31 dicembre 2019): 1–8. http://dx.doi.org/10.1182/bloodadvances.2019000773.
Mayer, Louisa, Maria Jasztal, Mercedes Pardo, Salvadora Aguera de Haro, Janine Collins, Tadbir K. Bariana, Peter A. Smethurst et al. "Nbeal2 interacts with Dock7, Sec16a, and Vac14". Blood 131, n. 9 (1 marzo 2018): 1000–1011. http://dx.doi.org/10.1182/blood-2017-08-800359.
Aarts, Cathelijn E. M., Kate Downes, Arie J. Hoogendijk, Evelien G. G. Sprenkeler, Roel P. Gazendam, Rémi Favier, Marie Favier et al. "Neutrophil specific granule and NETosis defects in gray platelet syndrome". Blood Advances 5, n. 2 (25 gennaio 2021): 549–64. http://dx.doi.org/10.1182/bloodadvances.2020002442.
Tang, Yuling, Hongping Wu, Caiyun Huo, Shumei Zou, Yanxin Hu e Hanchun Yang. "Transcriptomic Profiling of Mouse Mast Cells upon Pathogenic Avian H5N1 and Pandemic H1N1 Influenza a Virus Infection". Viruses 14, n. 2 (29 gennaio 2022): 292. http://dx.doi.org/10.3390/v14020292.
Di Paola, Jorge. "Novel Congenital Platelet Disorders". Blood 128, n. 22 (2 dicembre 2016): SCI—39—SCI—39. http://dx.doi.org/10.1182/blood.v128.22.sci-39.sci-39.
Kim, Dongjune A., Katrina J. Ashworth, Jorge Di Paola e David N. Ku. "Platelet α-granules are required for occlusive high-shear-rate thrombosis". Blood Advances 4, n. 14 (22 luglio 2020): 3258–67. http://dx.doi.org/10.1182/bloodadvances.2020002117.
Guerrero, Jose A., Cavan Bennett, Louise van der Weyden, Harriet McKinney, Melody Chin, Paquita Nurden, Zoe McIntyre et al. "Gray platelet syndrome: proinflammatory megakaryocytes and α-granule loss cause myelofibrosis and confer metastasis resistance in mice". Blood 124, n. 24 (4 dicembre 2014): 3624–35. http://dx.doi.org/10.1182/blood-2014-04-566760.
Tesi sul tema "NBEAL2":
Delage, Laure. "Des déficiences génétiques comme modèles naturels pour l'étude de la régulation des checkpoints immunitaires et la caractérisation des réponses auto-immunes". Electronic Thesis or Diss., Université Paris Cité, 2021. http://www.theses.fr/2021UNIP5190.
Recessive NBEAL2 mutations have been reported in patients with Gray Platelet Syndrome (GPS). This syndrome is characterized by a macro-thrombocytopenia, with platelets lacking alpha-granules, leading to bleeding disorders, often associated with splenomegaly. Thus, NBEAL2 plays a crucial role in the trafficking of alpha-granules in platelets. Moreover, our lab has also described NBEAL2 deficiencies in patients presenting clinical features of the autoimmune lymphoproliferative syndrome, suggesting a role of NBEAL2 in immune homeostasis and tolerance. A broader international cohort of GPS patients has been described, revealing immune system abnormalities (autoimmune diseases, autoantibodies, lymphopenia). If the role of NBEAL2 in the traffic of granules is often investigated, the exact mechanism leading to the development of autoimmune manifestations in GPS patients remains unknown. NBEAL2 belongs to a protein family involved in vesicular trafficking, all of which possess a conserved BEACH domain. Within this BEACH-domain containing proteins family, one of the closest members to NBEAL2 is LRBA. LRBA is involved in the recycling of CTLA-4, an inhibitory immune checkpoint. CTLA-4 plays a crucial role in the regulation of immune responses and tolerance. Recessive mutations of LRBA lead to similar clinical features as partial CTLA-4 deficiency: autoimmunity, lymphocytic infiltrations, and progressive B lymphopenia. Physiologically, LRBA prevents the lysosomal degradation of CTLA-4 and allows its recycling to the membrane. By analogy with LRBA, we investigated the importance of NBEAL2 in immune checkpoints intracellular trafficking and we brought new insights on its role in lymphocytes. Thus, NBEAL2 is a scaffold protein, binding LRBA, and involved in CTLA-4 trafficking as well as in vesicular trafficking in general. This work brings new knowledge to the regulation of CTLA-4 in activated T lymphocytes, a list of new partners for NBEAL2 protein and a new model of vesicular trafficking in which NBEAL2 is involved. Finally, a better understanding of the mechanisms leading to autoimmunity in patients with gray platelets syndrome could lead to better diagnosis and treatment management
Chang, Meng-Hsuan, e 張孟璇. "Key Factors in Family Business Succession - Case Studies of Public Companies in Taiwan". Thesis, 2019. http://ndltd.ncl.edu.tw/handle/nbezh2.
國立臺灣科技大學
管理研究所
107
Companies in Taiwan are mainly family-owned businesses, which account for a high proportion of economic contribution, thus significantly affecting the economy. Whether the family business succession transition has been implemented successfully is sufficient to affect Taiwan’s overall economy. Thus far, relevant studies on the inheritance of family businesses have focused mainly on a single related topic, thereby resulting in an inadequate understanding of the scope and insufficient discussion. This thesis aims to outline a framework and thus emphasize key areas of attention when addressing the transfer of a family business; it seeks to assist family members in conceptualizing and understanding this issue extensively for them to allow self-development of a comprehensive transfer plan that best suits the specificities of their families and businesses. This research uses “The Three-Circle Model of the Family Business System” framework (i.e., family members, shareholders, and enterprise) to examine issues that affect family businesses during transfer. This research conducts extensive interviews with members of three family businesses involved in public trading in Taiwan. Each of these companies has been in operation for more than 50 years. These interviews are conducted to derive critical factors in the transfer of family businesses.
Tsai, Chung-Han, e 蔡崇瀚. "The study of NbEILP from Nicotiana benthamiana involved in the cell-to-cell movement of Bamboo mosaic virus". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/65337367438434178777.
國立中興大學
生物科技學研究所
104
To study the interaction between the viral pathogens and their hosts, by cDNA-AFLP technique, we screened the differentially expressed genes from the Nicotiana benthamiana plants after inoculated with Bamboo mosaic virus (BaMV), a single-stranded positive-sense RNA virus. Among those differentially expressed genes, one of the upregulated genes ACCT8-1 is an ortholog of N. tabacum elicitor inducible leucine-rich repeats (LRR) protein gene (EILP) and Cladosporium fulvum resistance genes cf-2 and cf-5. In the previous study, by Tobacco rattle virus (TRV)-based silencing system, we knocked down the expression of ACCT8-1 in plants and resulting in reduced BaMV coat protein accumulation and lesion size on the inoculated leaves. Furthermore, the accumulation of BaMV coat protein in the ACCT8-1-knockdown protoplasts showed no significant difference to that in the control protoplasts. The results suggest that ACCT8-1 might be involved in the movement step of the BaMV infection cycle. Since the similarity of this gene is very similar to the EILP of N. tabacum, thus we designated this gene as NbEILP. To further reveal how the NbEILP is involved in the movement of BaMV, we fused the green fluorescent protein (GFP) at the C-terminus of the NbEILP. Unfortunately, because of the large gene size about 3.2 kb in length, the expression of this gene in plants was shown very difficult to detect. We then construct a deletion mutant removing the leucine-rich repeats domain (ΔLRR). The accumulation of BaMV coat protein is enhanced in the NbEILP/ΔLRR-GFP transient expressed leaves. The results indicate that the leucine-rich repeats domain is not essential in assisting BaMV movement. We then based on this construct NbEILP/ΔLRR-GFP to create a few deletion mutants such as NbEILP/ΔLRRΔTMD (without transmembrane domain), NbEILP/ΔLRRΔCD (without cytoplasmic domain), and NbEILP/ΔLRRΔSP (without signal peptide) to examine if these domains are involved in BaMV movement. The results of transient expression indicated that the two mutants NbEILP/ΔLRRΔTMD and NbEILP/ΔLRRΔSP could not enhance the accumulation of BaMV as that of NbEILP/ΔLRR. These results also suggest that NbEILP requires the signal peptide to target the right location and the transmembrane domain to associate the membrane in assisting the cell-to-cell movement of BaMV.
Libri sul tema "NBEAL2":
(Editor), Clarice P. Brantley, e Bobbye J. Davis (Editor), a cura di. The Changing Dimensions of Business Education: 1997 Nbea Yearbook (National Business Education Yearbook). National Business Education Association, 1997.
Rerreault, Heidi R. Classroom Strategies - The Methodology of Business Education: 1996 Nbea Yearbook (National Business Education Yearbook). National Business Education Association, 1996.
Atti di convegni sul tema "NBEAL2":
Wu, Weiji, Tao Zheng e Xitong Ning. "NBean: A HeteroPastry-Based P2P Proxy System". In 2009 5th International Conference on Wireless Communications, Networking and Mobile Computing (WiCOM). IEEE, 2009. http://dx.doi.org/10.1109/wicom.2009.5303154.
Zheng, Yuxuan, Huiwen Deng, Jianjun Chen, Jiaxiang Hu e Weihao Hu. "Degradation trajectories prognosis for fuel cell based on MP-NBEATS". In 2023 IEEE 4th China International Youth Conference On Electrical Engineering (CIYCEE). IEEE, 2023. http://dx.doi.org/10.1109/ciycee59789.2023.10401570.
Huang, Song, Danhong Zhang, Tuo Zheng, Guangbo Tong, Jianxin Xu e Fangzheng Jia. "Studies of short-term load forecasting model based on LSTM-NBEATS". In 2022 China Automation Congress (CAC). IEEE, 2022. http://dx.doi.org/10.1109/cac57257.2022.10055018.
S., Naveenkumar, Paras Rawat, Aditya Ganesh, Ashwath Ramakrishnan, Suresh Sankaranarayanan e Anis Salwa Binti Mohd Khairuddin. "Energy Generation Forecasting Based on Seasonality Using Deep Learning". In International Technical Postgraduate Conference 2022. AIJR Publisher, 2022. http://dx.doi.org/10.21467/proceedings.141.5.