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Letteratura scientifica selezionata sul tema "Nano-Compliance"

Autore: Grafiati

Pubblicato: 11 gennaio 2025

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Articoli di riviste sul tema "Nano-Compliance"

Ghabezi, P., e M. Farahani. "Trapezoidal traction–separation laws in mode II fracture in nano-composite and nano-adhesive joints". Journal of Reinforced Plastics and Composites 37, n. 11 (21 marzo 2018): 780–94. http://dx.doi.org/10.1177/0731684418761001.

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The main focus of this paper is on the experimental investigation and comparison between different bridging laws. For mode II fracture in the presence of nano-particles, these laws are calculated from three data reduction schemes for describing the bridging zone and trapezoidal traction–separation law parameters. For the calculation of the energy release rate in mode II fracture, three corresponding data reduction schemes, compliance calibration method, corrected beam theory and compliance-based beam method, have been utilized for different percentages of nano-particles in the adhesives and the adherents.

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Nayak, Lakshmi, Annette Molinaro, Katherine Peters, Jennifer Clarke, Justin Jordan, John de Groot, Phioanh Nghiemphu et al. "NCOG-44. NEUROLOGIC ASSESSMENT IN NEURO-ONCOLOGY (NANO) SCALE IN A PHASE II STUDY OF PEMBROLIZUMAB OR PEMBROLIZUMAB PLUS BEVACIZUMAB IN PATIENTS WITH RECURRENT GLIOBLASTOMA". Neuro-Oncology 22, Supplement_2 (novembre 2020): ii138—ii139. http://dx.doi.org/10.1093/neuonc/noaa215.582.

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Abstract PURPOSE The neurologic assessment in neuro-oncology (NANO) scale was developed as a standardized metric to objectively measure neurologic function in brain tumor patients to complement radiographic assessment in defining overall outcome. A multicenter, phase 2 study of pembrolizumab with or without bevacizumab in patients with recurrent glioblastoma incorporated the NANO scale as an exploratory endpoint. METHODS Neurologic examination was evaluated at baseline and MRI assessments using the NANO scale until patients came off study. Statistical descriptive data analysis was performed using R (version 3.4.3). Correlation analysis utilized Fisher’s exact test. RESULTS NANO compliance rate was 94% in 80 patients accrued on the study. Of the 80 patients, 7 were missing NANO at baseline visit and were excluded from analysis for NANO response criteria. Fifteen patients did not have end of treatment NANO evaluation. Of 73 patients, 35 (48%) had a normal neurologic examination at baseline by NANO. Strength and language accounted for the majority of changes in neurologic function over the course of study treatment. Eighteen patients (25%) had neurologic progression by NANO, of whom 2 did not have concurrent radiographic progression. Three patients (pembrolizumab plus bevacizumab cohort) had a neurologic response associated with stable disease on MRI. NANO assessment prior to initiation of cycle 3 correlated with RANO response (p=0.011), change in KPS (p=0.002) and dexamethasone requirement (p=0.007) while those with NANO progression at this assessment had worse overall survival (291 vs 324 days), but this trend did not achieve statistical significance (p=0.2). CONCLUSIONS Evaluation of neurologic function by NANO scale was feasible in a multicenter prospective study in patients with GBM with a high compliance rate. The NANO scale objectively tracked stable neurologic function in most patients throughout the trial period and was associated with a trend for survival.

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Lim, Chooi Ling, Chandramathi S. Raju, Tooba Mahboob, Sunil Kayesth, Kamal K. Gupta, Gaurav Kumar Jain, Mahaveer Dhobi et al. "Precision and Advanced Nano-Phytopharmaceuticals for Therapeutic Applications". Nanomaterials 12, n. 2 (12 gennaio 2022): 238. http://dx.doi.org/10.3390/nano12020238.

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Phytopharmaceuticals have been widely used globally since ancient times and acknowledged by healthcare professionals and patients for their superior therapeutic value and fewer side-effects compared to modern medicines. However, phytopharmaceuticals need a scientific and methodical approach to deliver their components and thereby improve patient compliance and treatment adherence. Dose reduction, improved bioavailability, receptor selective binding, and targeted delivery of phytopharmaceuticals can be likely achieved by molding them into specific nano-formulations. In recent decades, nanotechnology-based phytopharmaceuticals have emerged as potential therapeutic candidates for the treatment of various communicable and non-communicable diseases. Nanotechnology combined with phytopharmaceuticals broadens the therapeutic perspective and overcomes problems associated with plant medicine. The current review highlights the therapeutic application of various nano-phytopharmaceuticals in neurological, cardiovascular, pulmonary, and gastro-intestinal disorders. We conclude that nano-phytopharmaceuticals emerge as promising therapeutics for many pathological conditions with good compliance and higher acceptance.

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Shinde, Snehal M., Priti U. More, Smita P. Borkar, Vishal D. Yadav, Swapnil D. Zambare e Shrikrushn B. Sontakke. "New Trends in Emerging Novel Nanosponges Drug Delivery". Asian Journal of Pharmaceutical Research and Development 12, n. 2 (15 aprile 2024): 52–63. http://dx.doi.org/10.22270/ajprd.v12i2.1360.

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Medical professionals have long had trouble delivering medications to the correct location in the body and controlling their release to prevent overdose. Nano-sponges are novel and complicated molecules, which have the ability to alleviate these challenges. Utilizing nano-sponges allows for precise drug delivery to the desired location. Nano-sponge technology gets better patient compliance by delivering drugs to strategic locations while also extending dosing intervals. Various drug delivery techniques, such as parenteral, transdermal, oral, and immunosuppressive drugs, involve Nano-sponges. In today's world, nanosponges are used in gastro-retentive drug delivery systems.

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Lee, Dong Keun, Min-Hwi Kim, Suhyun Bang, Tae-Hyeon Kim, Sungjun Kim, Seongjae Cho e Byung-Gook Park. "Multilevel Switching Characteristics of Si3N4-Based Nano-Wedge Resistive Switching Memory and Array Simulation for In-Memory Computing Application". Electronics 9, n. 8 (30 luglio 2020): 1228. http://dx.doi.org/10.3390/electronics9081228.

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In this research, nano-wedge resistive switching random-access memory (ReRAM) based on a Si3N4 switching layer and silicon bottom electrode was fabricated, and its multilevel switching characteristics were investigated. The wedge bottom electrode was formed by a tetramethyl ammonium hydroxide (TMAH) wet-etching process. The nano-wedge ReRAM was demonstrated to have different reset current levels by varying the compliance currents. To explain the effect of modulating the compliance currents, the switching characteristics of both the SET and RESET behaviors were shown. After measuring the device under four different compliance currents, it was proved to have different current levels due to an inhibited resistive state after a SET switching process. Furthermore, SPICE circuit simulation was carried out to show the effect of line resistance on current summation for the array sizes of 8 × 8 and 16 × 16. These results indicate the importance of minimizing the line resistance for successful implementation as a hardware-based neural network.

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Tang, Jingyu, Luhan Bao, Xue Li, Lin Chen e Feng F. Hong. "Potential of PVA-doped bacterial nano-cellulose tubular composites for artificial blood vessels". Journal of Materials Chemistry B 3, n. 43 (2015): 8537–47. http://dx.doi.org/10.1039/c5tb01144b.

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Introduction of PVA can improve the compliance of bacterial nano-cellulose hydrogel, which has been suggested as a promising biomaterial for artificial blood vessels especially for small-caliber vessels.

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Park, Soyeun, e Yong J. Lee. "Nano-mechanical Compliance of Müller Cells Investigated by Atomic Force Microscopy". International Journal of Biological Sciences 9, n. 7 (2013): 702–6. http://dx.doi.org/10.7150/ijbs.6473.

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Gražulytė, Judita, Audrius Vaitkus e Simona Bitarytė. "Optimisation Of Nano-ZnO And Nano-SiO₂ Mixing Time For Bitumen Modification". IOP Conference Series: Materials Science and Engineering 1202, n. 1 (1 novembre 2021): 012017. http://dx.doi.org/10.1088/1757-899x/1202/1/012017.

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Abstract Nanotechnologies have gradually penetrated to the field of bitumen modification especially where durable asphalt mixtures have to be designed. Longer mixing time, higher temperatures or/and higher rotation (shearing) speeds are needed to increase the dispersion of nanoparticles in bitumen. However, this is not necessarily beneficial to the physical and mechanical properties of the final material. As a result, in this study nano-zinc oxide (nano-ZnO) and nano-silica (nano-SiO2) mixing time for bitumen modification was optimized considering the physical and mechanical properties of the final bitumen. For this purpose bitumen PMB 25/55-60 was modified with nanoparticles at 180 °C using a laboratory high-shear mixer at a rotation speed of 4000 rpm for different modification time selected on the basis of literature review (60 and 90 minutes). Penetration, softening point, viscosity at 135 °C, recovery and non-recoverable creep compliance (multiple stress creep and recovery test) at 60 °C were measured in order to determine the optimal mixing time. The results showed that 60 minutes ensures the dispersion of nano-ZnO and nano-SiO2 in the bitumen PMB 25/55-60 and longer mixing time do not have a significant effect on the properties of nano-ZnO and nano-SiO2 modified bitumen (the difference was less than 7%).

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Li, Jinyin, Peng Yan e Jianming Li. "Displacement amplification ratio modeling of bridge-type nano-positioners with input displacement loss". Mechanical Sciences 10, n. 1 (25 giugno 2019): 299–307. http://dx.doi.org/10.5194/ms-10-299-2019.

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Abstract. This paper presents an improved modeling method for bridge-type mechanism by taking the input displacement loss into consideration, and establishes an amplification ratio model of bridge-type mechanism according to compliance matrix method and elastic beam theory. Moreover, the amplification ratio of the designed bridge-type nano-positioner is obtained by taking the guiding mechanism as the external load of bridge-type mechanism. Comparing with existing methods, the proposed model is more accurate, which is further verified by finite element analysis(FEA) and experimental test. The consistency of the results obtained from theoretical model, FEA and experimental testing indicates that the proposed model can accurately predict the amplification characteristics of nano-positioners, which helps the analysis and design of bridge-type nano-positioners in practical applications.

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Rehman, Mehreen, Abida Raza, Jamshaid Ali Khan e M. Aslam Zia. "Laser Responsive Cisplatin-Gold Nano-Assembly Synergizes the Effect of Cisplatin With Compliance". Journal of Pharmaceutical Sciences 110, n. 4 (aprile 2021): 1749–60. http://dx.doi.org/10.1016/j.xphs.2021.01.012.

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Più fonti

Tesi sul tema "Nano-Compliance"

Wehbe, Maya. "Modélisation et caractérisation des effets de nano-compliance pour la croissance épitaxiale localisée de GaN sur substrats Si". Electronic Thesis or Diss., Université Grenoble Alpes, 2024. http://www.theses.fr/2024GRALY041.

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Le nitrure de gallium (GaN) est un semiconducteur prometteur pour les microLEDs, mais lacroissance hétéroépitaxiale du GaN génère des dislocations qui réduisent leur efficacitéd’émission. Afin d’améliorer la qualité du GaN épitaxiée, on propose une approche qui consisteà faire la croissance des pyramides de GaN au-dessus de nanopiliers de GaN/AlN/Si(111)/SiO2.L’excès d’énergie à l'interface de chaque pyramide permettra aux piliers de subir une rotationdurant la coalescence des pyramides de GaN qui sont au-dessus afin que ceux-ci se coalescenten s’alignant cristallographiquement. Les objectifs de cette thèse sont de comprendre lesphénomènes qui ont lieu durant la coalescence, déterminer la qualité des couches GaNobtenues, étudier la rotation des piliers et proposer un modèle de piliers optimales. Ainsi,différents échantillons ont été caractérisés par la diffraction d'électrons rétrodiffusés, lacathodoluminescence et différentes techniques avancées de diffraction des rayons X réalisées àl’European Synchrotron Radiation Facility. Les résultats ont confirmé la rotation des piliers de0.1° après coalescence ainsi que la réalisation des lignes de GaN très homogènes (densité dedislocations ≈1.2 x 107 cm-2). Nous avons pu suivre le comportement du GaN au début de lacoalescence ; les piliers de GaN initialement désorientés sont transformés en gros îlots de GaNbien définis et bien orientés en eux-mêmes. La présence des dislocations au niveau des jointsde grains a été confirmé. De plus, nous avons constaté que tant que l'inclinaison entre les piliersvoisins ne dépasse pas 0.1°, les piliers voisins contribuent à former des domaines cristallinssimilaire en taille à ceux formés au début de la coalescence. Des simulations éléments finis etdes calculs analytiques ont permis d’optimiser les différents paramètres des piliers. Le rayon(r) du pilier a été identifié comme le paramètre ayant le plus grand impact sur l'énergienécessaire à la rotation car cette dernière a été trouvé proportionnelle à r4. Ces résultats ontpermis la réalisation d'un nouveau modèle de piliers optimisé qui a montré des résultatsprometteurs et permettra la fabrication d'îlots GaN de haute qualité adaptés aux microLEDs
Gallium nitride (GaN) is a promising semiconductor for microLEDs, but heteroepitaxial growthof GaN generates dislocations that reduce their emission efficiency. To improve the quality ofthe GaN, we propose novel approach based on growing GaN pyramids on top ofGaN/AlN/Si(111)/SiO2 nano-pillars. The approach relies on the excess surface energy at eachpyramid's interface to allow the pillars to tilt/twist, coalescing and aligning the GaN on top. Themain objective of this work is to gain a physical understanding of the processes operating duringcoalescence, determine the GaN quality, investigate the tilt/twist of the pillars and propose anoptimal pillars pattern. Therefore, different samples were studied by electron backscatterdiffraction, cathodoluminescence and advanced X-ray diffraction techniques at the EuropeanSynchrotron Radiation Facility. The results demonstrated the rotation of pillars by 0.1°. Weshowed that achievement of homogenous GaN layers in lines of pillars (dislocation density ≈1.2 x 107 cm-2). We were able to follow the behavior of the GaN at the early stage ofcoalescence, in fact, the initially misoriented GaN pillars, were found to coalesce into largerwell-defined GaN domains with a unique orientation distribution within each domain and a tiltlimit of 0.1° between neighboring pillars was found. Geometrically necessary dislocations werefound at the grain boundaries of the GaN domains. To complete the work, finite elementsimulations and analytical calculations are performed to identify the optimal parameters thatmake the pillars rotation energetically feasible; the radius (r) of the pillar was identified as theparameter with the greatest impact as the energy required to rotate is proportional to r4. Theseresults allowed the realization of new optimized pillars pattern that showed promising resultsand will allow the fabrication of high quality GaN islands suitable for microLEDs

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Thakur, Rookmoney. "The quality of selected food products containing nanosilica additive (E551) in South Africa". Thesis, 2017. http://hdl.handle.net/10321/2513.

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Submitted in fulfilment of the requirements for the Degree Master of Philosophy: Quality Management, Durban University of Technology, 2017.
The proliferation of nanotechnology, whilst perceived to be positive for human advancement, introduces potential risks when applied to food. Silicon Dioxide (E551), a common food additive made up of particles in the nano-range, is found in spices, salt, sweets and some frozen foods and functions as an anti-caking agent to allow these food products to flow and mix evenly. According to Codex Alimentarius, E551 is generally regarded as safe (GRAS), provided that food manufacturers apply good manufacturing practice (GMP) principles and use the lowest possible amounts necessary. Smaller nanoparticles are more readily taken up by the human body than larger sized particles and could be injurious to human health. While the use of E551 is strictly regulated in some countries, there is growing debate regarding the health and safety implications for consumers and the quality of food. This study examined the quality of selected food products containing E551 (nanosilica) in South Africa (SA). A mixed method paradigm (qualitative and quantitative) and an experimental research strategy were adopted. Respondents were purposefully selected, their participation in this study was voluntary and confidentiality was maintained. Pilot studies were conducted for the semi-structured interviews and the survey, with a sample size of one food expert and three food technologists, respectively. The main study consisted of interviews, a survey and experimental work. The interviews, conducted with five food experts, were recorded and transcribed to ensure credibility. The results were interpreted and analysed against existing literature using thematic content analysis. The findings suggest that it was critical for food manufacturers to demonstrate the safe use of products without posing any safety risks to the consumer and the environment; and for the South African government to address and regulate the application of nanomaterials in food either by legislation or guidelines. The survey was conducted with a sample population of thirty food technologists who reported that public awareness of nanotechnology was limited as many consumers were not familiar with this technology. Descriptive and inferential statistics were used to analyse the quantitative data. Content validity ensured that the survey focused on concepts and constructs that emerged from the review of literature on the application of nanotechnology in food products. Cronbach’s alpha index was used to assess the reliability of the surveys and found α = 0.862 and α = 0.809 for food additives awareness and nanosilica safety in food, respectively. Different characterisation methods, such as Fourier Spectra Infrared Spectroscopy (FT-IR), Energy Dispersive X-ray Spectroscopy (EDX) and X-ray Diffraction (XRD), were used to determine the type and form of silica, and its levels in selected food brands available in SA. This was compared against similar products manufactured and packed in the European Union (EU) and Asia. This study benchmarked against the EU standard because of its more stringent guidelines in the field of nanotechnology and regulations. The results indicate that while the comparative EU food sample conformed to the European Food Safety Association (EFSA) permissible level of 1 %, the South African sample levels were higher. Even though the regulatory standards are different in both countries, the potential health effects remain the same. Significantly, the most prominent finding of this study is that the form of silica in some of the South African and Asian products were crystalline in nature, rather than synthetic amorphous silica (SAS), which is indicative of E551. Thus, it stands to reason that the generalised limit set by Codex Alimentarius was inadequate to regulate and control the quantity and type of E551 used as it varied from each of the selected samples. The identification of traces of crystalline silica is of concern since studies in literature showed that exposure to and ingestion of crystalline silica that was not food grade, is likely to induce perilous health effects such as cancer and fibrosis in humans. In light of this finding on the crystalline nature of silica in the studied brands, it is therefore imperative that specific limits and regulations be put in place and enforceable in SA to ensure that products sold are in line with acceptable standards as found in some developed countries like the United States of America (US) and EU. In view of the above, and to ensure proper monitoring and minimal risk exposure, a risk management framework, a ‘Hazard identification, Access the risks, Control the risks’ (HAC) model, was developed and recommended to ensure that the correct form and type, and limits of silica is used and the associated risk controls applied.
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Capitoli di libri sul tema "Nano-Compliance"

Kocaman, Suheyla. "Recent Trends in Smart Medicine and Nanotechnology for Diabetes: a Novel Strategy". In Current Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism, 151–59. Istanbul: Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359104.14.

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Recent advancements in smart medicine and nanotechnology have introduced transformative approaches to managing diabetes mellitus, focusing on enhancing monitoring, diagnosis, and therapeutic interventions. Smart medicine leverages wearable devices, biosensors, and mobile health applications to enable continuous glucose monitoring (CGM) systems that provide real-time insights into glucose levels and metabolic trends. These systems not only improve patient compliance but also empower individuals with diabetes and their healthcare providers to make informed decisions regarding insulin dosing and dietary adjustments. Moreover, nanotechnology has revolutionized drug delivery systems with the development of nano-sized carriers and biomaterials that enhance the stability, bioavailability, and targeted delivery of insulin and other therapeutics. Nanosensors integrated into CGM devices offer enhanced sensitivity and specificity in glucose monitoring, potentially replacing traditional invasive methods with non-invasive alternatives. Additionally, nanotechnology facilitates the development of implantable devices and tissue-engineered constructs aimed at restoring pancreatic function and ameliorating diabetic complications. By integrating smart medicine and nanotechnology, these innovative strategies pave the way for personalized diabetes management, improved treatment outcomes, and enhanced quality of life for individuals living with diabetes.

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Tokunaga, Hitoo, Kiyohiko Dceda, Koichi Kaizu e Hiroyuki Kinoshita. "Evaluation of KI-V Relation in Ceramics by Using Dt Technique (Crack Length Measurement by Using Compliance Method)". In Experimental Analysis of Nano and Engineering Materials and Structures, 185–86. Dordrecht: Springer Netherlands, 2007. http://dx.doi.org/10.1007/978-1-4020-6239-1_91.

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Tahrani, M., I. Adam, A. Reinhardt, M. Al-Haik e M. Reda Taha. "Nano versus macro creep compliance of concrete". In Creep, Shrinkage and Durability Mechanics of Concrete and Concrete Structures, 229–35. Taylor & Francis, 2008. http://dx.doi.org/10.1201/9780203882955.ch27.

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Bakliwal, Akshada, Swati Gokul Talele, Shweta Shaileshkumar Gedam, Vijay Sharadkumar Chudiwal e Swapnil Sharadkumar Jain. "Nanoparticulate Drug Delivery System". In Advances in Medical Diagnosis, Treatment, and Care, 173–85. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-4453-2.ch007.

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The herbal medicines have been extensively used worldwide since ancient times and have been accepted by physicians and patients for their improved therapeutic value as they have less adverse effects in contrast with modern medicines. Phytotherapeutics requires a scientific approach to carry the components in a sustained manner to increase patient compliance and to reduce the frequency of administration. This can be accomplished by designing novel drug delivery systems (NDDS) for herbal constituents. NDDSs not only reduce the frequency of drug administration to improve patient compliance but also help to enhance the therapeutic value by dropping toxicity and enhancing the drug bioavailability. A nanotechnology is a new approach in which nano-sized drug delivery systems of herbal drugs have a prospective future for enhancing the therapeutic activity and conquer problems associated with plant medicines. Hence, the addition of the nanotechnology as an NDDS in traditional medication is essential for the treatment of more chronic diseases like cancer, diabetes, asthma, and others.

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Lanjhiyana, S. K., Gopal Bihari, Sanmati Kumar Jain, Sweety Lanjhiyana e Sakshi Gupta. "POLYMERIC LIPOSPHERE DRUG DELIVERY SYSTEM: REVIEW ON PREPARATION METHODS AND DISEASE MANAGEMENT". In Futuristic Trends in Chemical Material Sciences & Nano Technology Volume 3 Book 12, 255–62. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3becs12p2ch9.

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The biggest and most accessible organ of the body is the skin. Topical medication delivery has become more and more popular among people as the prevalence of dermatological problems, desire for drug targeting, and patient compliance have all grown. The stratum corneum, the top layer of the epidermis, blocks the penetration of most pharmaceuticals, making drug administration over the skin a difficulty for researchers. To administer the medications topically, a variety of techniques have been utilised, including the use of chemical permeation enhancers and physical techniques including sonophoresis, iontophoresis, electroporation, microneedles, etc. There are certain restrictions and disadvantages to these approaches to topical administration of drugs. Therefore, new techniques based on nano delivery system such as liposphere gels has been developed for the treatment of disease like osteoarthritis which is common in old age people.

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Sharma, Mani, Neeraj Kumar Chouhan, Sandeep Vaidya e Mamta N. Talati. "Lipids, Peptides, and Polymers as Targeted Drug Delivery Vectors in Cancer Therapy". In Handbook of Research on Advancements in Cancer Therapeutics, 255–75. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-6530-8.ch007.

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The authors aim to describe valuable information and experimental reviews that may help to develop and design different formulation, which can boost up the overall efficiency of the final product. Further, they explained the overall efficiency, method of preparation, target delivery approaches, drawbacks, and other characteristics in relation to lipids, peptides, polymers, and vaccines. In addition, they also propose to uncover the physico-chemical properties, in-process manufacturing issues, and external factors that influence the fate of a medicine. That major includes the excipients, method of preparation, dose, delivery route, chemical and biological properties, drug-drug interaction, drug-body interaction, patient compliance, modifications in lipid based nano-vectors, polymer-mediated delivery systems, conjugate delivery systems, and others. In conclusion, by the end of this chapter, the authors are able to explain a robust mode of delivering active constituents more safely and economically to the target site by showing maximum bioavailability.

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Chavan, Rahul B., e Nalini R. Shastri. "Overview of Multicomponent Solid Forms". In Alternative Pain Management, 65–102. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-1680-5.ch004.

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Multi-drug therapy involves the simultaneous or sequential administration of two or more drugs with similar or different mechanisms of action and is efficient in combating various ailments such as cancer, diabetes, and rheumatoid arthritis. It has emerged advantageous due to larger therapeutic benefits, an increase in patient compliance, lower administrative costs, and reduced number of prescriptions. In the recent past, the clinical success of the Novartis product Entresto (sacubitril, disodium valsartan and water) and Esteve product E-58425 (tramadol and celecoxib) has boosted the development of multi-drug . The present article is hence designed to provide an overview of different multicomponent addicts which provide option of combining the drugs at a supramolecular level (nano-sized level). Key features of multi-drug cocrystal, co-amorphous system and eutectics are described with major emphasis on screening tools, preparation methods, characterization techniques, biopharmaceutical aspects and scale up.

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Pancholi, Shyam S., Aseem Setia, Manu Singhai e Atul Chaudhary. "Nanocarrier-based Targeted Delivery in Cancer". In Nanoparticles and Nanocarriers-Based Pharmaceutical Formulations, 197–229. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815049787122010010.

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Anticancer agents are known for their cytotoxic action against tumors, but the spread of their activity to noncancerous tissue is highly undesirable and may be toxic. The conventional methods of drug delivery pose numerous restrictions, involving side effects, lack of patient compliance, etc. Nanocarrier-based drug delivery alternatives offer the potential for the management of cancer, as they not only confer better delivery but also efficient targeting to the tissues with limited toxicity. Nanoparticles offer localization in tumors in the vicinity of capillaries, that accounts for improved penetration and prolonged detainment of drug in tumors. Under the tremendous potential of nanoparticles. The exploitation of multi-functional nanocarrier approaches is a burgeoning research subject, driven by increasing medical needs in the area of cancer therapy. Several nano-formulation have been approved for the treatment of cancer. This chapter is an attempt to provide an overview of the recent developments in nanoparticle formulations for cancer treatment and presents a comprehensive outlook of the clinical studies and utilization in different prevalent cancers affecting the brain, lung, breast, colon, cervix, and prostate, etc.

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Singh, Aditya, Mohammad Saleem, Pankaj Kumar, Poonam Kumari, Durgesh Singh e Shubhrat Maheshwari. "DENDRIMERS IN ALZHEIMER'S DISEASE: CURRENT STATE AND FUTURE DIRECTIONS". In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 9, 121–37. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bipn9ch13.

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Alzheimer's disease (AD), neuronal death, and synaptic loss are all characterized by extracellular amyloid-(A) plaques and neurofibrillary in the intracellular milieu, all of which lead to progressive cognitive impairment. The prevalence of AD exponentially rises after age 65, making age the most major risk factor for the disease. It is expected that during the next 20 years, the overall prevalence of AD will double as the average lifespan in emerging nation’s increases. Ideal drug delivery systems depend on the pharmacokinetics and pharmacodynamics of many innovative formulations to achieve the following characteristics: efficient drug transport to the target tissue, consistent therapeutic drug concentrations, a reduction in dose quantity and frequency, and increased patient compliance. Various dendrimers-based formulations, include orally disintegrating tablets, extended-release capsules, and numerous attempts to develop alternative delivery systems, including Three basic components make up a typical dendrimer molecule: a central core composed of at least two identical functional groups on an atom or molecule; branching units that emerge from the central core; and various peripheral surface functions, such as drug delivery, a nose-to-brain delivery system, and nano formulations with various nano-carriers for the treatment of AD. Fate of all the novel formulations depends on the Pharmacokinetics and Pharmacodynamic behavior of the drug substances. Pharmacokinetics (PK) studies the disposition of drug molecules in the body, including their concentration patterns and AUC last, Tmax, Cmax, and AUC in values Pharmacodynamic (PD) assessment looks at how a drug affects the body includes variations in Emax, EC50, in an Emax- model parameter. A drug must cross the blood brain barriers and be absorbed by the specific tissues in order for it to be effective in treating an Alzheimer patient (as measured by PK studies). To successfully alter the target protein activity in the body (as determined by PD studies), this is required. This chapter will focus on the various novel formulations Targeting AD and its Pharmacokinetics and Pharmacodynamics behaviour.

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Mehraj, Safiya, e Zahoor Ahmad Parry. "War against ESKAPE Pathogens". In Infectious Diseases. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.112853.

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ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are the prominent reasons of Healthcare-Acquired Infections (HAIs) with multidrug resistance against vancomycin, carbapenem, methicillin, and extended spectrum β-lactamases (ESBL). Multidrug resistance develops owing to inappropriate prescription, poor quality pharmaceuticals, patient non-compliance, and use of antimicrobials as growth promoters. The worst is the fact that resistance development and spread are continuous processes to the extent that present times are times of extensively drug resistant and totally drug resistant pathogens (confirmed worldwide). These dangerous pathogens pose global threat of the magnitude to the extent of reversing the situation to pre-antibiotic era as they have left majority of efficient antibiotics futile and estimates show expected death rates are 10 million/year by 2050. Considering this global havoc due to ESKAPEs intensive research from academia and industry is going on with significant success about the causes, mechanisms, spreading ways, and most importantly the novel/alternative strategies to combat them all. Substitute therapies such as combination use of antibiotics or immunomodulators/adjuvants with antibiotics, nanoparticles, antimicrobial peptides (AMPs), AMPs with antibodies, star polymers, and structurally nano-engineered antimicrobial peptide polymers (SNAPPs) all these aspects are well discussed and reviewed here.

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Atti di convegni sul tema "Nano-Compliance"

Wang, Huijing, Tao Mei e Xiaohua Wang. "Modelling and Rough Surface Compliance Analysis of Biomimetic Micro/Nano Adhesive Array". In 2007 International Conference on Information Acquisition. IEEE, 2007. http://dx.doi.org/10.1109/icia.2007.4295719.

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Ma, Ou, Xiumin Diao e Mingjun Zhang. "Simulation of Nanomanipulation Using Compliance-Based Contact Dynamics Modeling Technique". In ASME 2007 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/detc2007-35691.

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This paper describes dynamics modeling and simulation of AFM-based manipulation of a nano-scale object using the compliance-based contact dynamics modeling technique (also referred to as the penalty method). Such a modeling technique has been well developed and widely applied in macro-scale applications. Its applicability to nano-scale cases is, however, relatively new and thus, requires more investigation. The dynamics model developed in the paper includes the Van der Waals forces, electrostatic forces, contact forces (for modeling repulsion), and friction forces with consideration of contact geometry, stiffness, and friction properties of all the physically interacting objects. The model can simulate the dynamic behavior of interactions between nano-scale objects and its environment. For demonstration, the dynamic simulation results of an AFM-based manipulation process are presented. To provide confidence of the model fidelity, a simulation example which matches some published data is presented.

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Patil, Chinmaya B., S. V. Sreenivasan e Raul G. Longoria. "Robust Design of Flexure Based Nano Precision Compliant Mechanisms With Application to Nano Imprint Lithography". In ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/detc2008-50114.

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Flexure-based compliant mechanisms are the preferred motion guiding systems for small range, nano-precision positioning applications because of excellent characteristics like friction-free continuous motion. These mechanisms are commonly used in nano fabrication equipment and ultra precision instruments. However, machining imperfections induced geometric errors in the mechanisms are known to cause undesirable parasitic motion and significant loss of precision. A systematic design approach to minimize the sensitivity of the flexure mechanisms to geometric errors induced by machining tolerances is presented here. Central to the design approach is the screw systems based analytical model to study the spatial motion characteristics of flexure mechanisms. Using this model, the parasitic motion is classified into those errors which can be corrected by calibration (extrinsic) and those which are coupled with the mechanism motion and cannot be corrected by apriori calibration (intrinsic). Metric to quantify the intrinsic parasitic motion results naturally from the screw systems analysis, and is used to represent the precision capability of the flexure mechanism. The analytical model enables the selection of geometric parameters of flexure joints of the mechanism via an optimization scheme with the aim of minimizing the parasitic motion metric. The statistical nature of the machining tolerances is accounted for by sampling the random variables at every iteration step of the optimization, leading to a stochastic formulation. The robust design approach is illustrated using a one DOF rotational flexure mechanism that is used in nano-imprint lithography equipment. Numerical results of the optimization indicate up to 40% improvement in the precision capability of the mechanism without any change in the manufacturing tolerance limits. Further, it is shown via eigenscrew analysis of mechanism compliance that the robustness resulting from the optimal flexure joint design can be attributed to the improved compliance distribution.

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Choi, Young, In Kim, Sung Jang e Jae Lee. "Structural Design Optimization of a Thermal Nano Imprinting Machine for Minimum Compliance by Using Genetic Algorithm". In 2006 SICE-ICASE International Joint Conference. IEEE, 2006. http://dx.doi.org/10.1109/sice.2006.314790.

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Napolean, A., N. M. Sivamangai, Joel Samuel e Vimukth John. "Overview of Current Compliance Effect on Reliability of Nano Scaled Metal Oxide Resistive Random Access Memory Device". In 2018 4th International Conference on Devices, Circuits and Systems (ICDCS). IEEE, 2018. http://dx.doi.org/10.1109/icdcsyst.2018.8605178.

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Yang, Bozhi, Burak Aksak, Shan Liu, Qiao Lin e Metin Sitti. "Compliant and Low-Cost Humidity Sensors Using Nano-Porous Polymer Membranes". In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-59557.

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This paper proposes non-fragile compliant humidity sensors that can be fabricated inexpensively on various types of nano-porous polymer membranes such as polycarbonate, cellulose acetate, and nylon membranes. The sensor contains a pair of interdigitated electrodes deposited on the nano-porous polymer membranes. The resistance and/or capacitance between these electrodes vary at different humidity levels with a very high sensitivity due to the water adsorption (capillary condensation) inside the nano-pores. The proposed sensors are low-cost in both material and fabrication. Due to its compliance, the sensors can be suitable for certain applications such as in-situ water leakage detection on roofs, where people can walk on top of them. Testing results demonstrated that the sensor changes resistance within large range of humidity values. For most sensors, the resistance changes from 0.1 GΩ to 2000 GΩ when the relative humidity changes from 39% to 100% at room temperature. It takes about 4–8 minutes for the resistance to reach steady state when the sensor was taken from 100% to 39% relative humidity at the room temperature.

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Zheng, Weikang, Zhigang Liu e Junkang Guo. "An Optimized 3D Probe Using Sensitivity and Compliance Analysis". In ASME 2019 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/imece2019-11184.

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Abstract High-precision micro/nano probe plays an increasingly important role in manufacturing and measurement. The multi-arm elastic mechanism that can produce deformation under the contact force is widely used in the design of probe. The striking feature of this mechanism is that multiple variables are coupled to each other and are not easily separated. However, the transfer matrix of probe, rather than a multivariable decoupling model, is widely used as a measurement model in traditional research. Transfer matrix appears as a “black box” and does not reveal working principles of probe. Our previous research proposed a 3D decoupling model. The 3D model presents the coupling relationship between input and output variables, and also finishes a theoretical explanation of complex features of 3D probe. Recent studies have found that this decoupling model has practical value in parameter and shape optimization of probe. As the optimized purpose, two indicators — sensitivity and compliance (reciprocal of stiffness) are proposed from the model. The increased sensitivity means the probe has a lower resolution requirement for the capacitive sensor used. High compliance of probe means small contact force between the stylus ball and workpiece. Excessive stiffness can cause excessive contact forces that damages surface of workpiece. Combined with theoretical model and finite element analysis (FEA), the key parameters affecting sensitivity and compliance of probe are extracted, and a new optimized elastic mechanism based on an original Hexflex mechanism. The new optimized probe has better performance with sensitivity, input compliance, output compliance increased by 78.6%, 48.4%, 157.7%, respectively.

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Cole, Daniel P., e Ed M. Habtour. "Improved Understanding of Damage Precursors Through Local Mechanical Characterization". In ASME 2015 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/smasis2015-8822.

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We report on the use of local mechanical characterization techniques for the understanding of structural damage precursors in various material systems. Instrumented indentation and atomic force microscopy (AFM) were used to characterize local damage in: (1) fatigued metallic beams subject to non-linear vibration, (2) individual polymer and glass microfibers, and (3) additive manufactured thermoplastics. Indentation studies of the fatigued metallic beams showed a compliance effect of up to 40% in relatively highly stressed regions. An approved fiber mounting technique allowed for indentation of unmodified surfaces of single microfibers, while AFM modulus maps of the fibers reveal local regions of relative compliance. Local mechanical tests of 3-D printed acrylonitrile butadiene styrene specimens revealed a variation in properties between printed beads and bead-bead interfaces. The nano-/micro-scale techniques developed in the present study provide a framework for understanding how damage precursors may affect processing-structure-property relationships in present and future structural aerospace materials.

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Силиванов, Михаил Олегович, e Юлия Денисовна Сопина. "ENGINEERING OF A DEVICE FOR MEASURING THE OSCILLATION PERIOD OF A BALLISTIC PENDULUM". In Перспективы инновационных научно-практических исследований и разработок: сборник статей международной научной конференции (Санкт-Петербург, Февраль 2023). Crossref, 2023. http://dx.doi.org/10.37539/230224.2023.16.18.002.

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В статье представлена работа по моделированию и изготовлению установки для измерения периода колебаний баллистического маятника при помощи современных систем проектирования. Также собрана установка на базе процессора «Arduino NANO» и написана программа, обеспечивающая корректное функционирование оборудования в соответствии с поставленными задачами измерения времени и количества колебаний системы. The purpose of this work was to design and manufacture using modern systems for designing the cases of the device and the light sensor with a laser. A program was also written to ensure the correct functioning of the equipment in compliance with the goals.

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Lellep, Jaan, e Mainul Hossain. "Free vibration of rectangular nanoplate strips". In The 13th international scientific conference “Modern Building Materials, Structures and Techniques”. Vilnius Gediminas Technical University, 2019. http://dx.doi.org/10.3846/mbmst.2019.026.

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Natural vibrations of nanobeams and nanosheets are investigated with the help of nonlocal theories of elasticity. The vibration analysis is based on the size-dependent non-local theory of elasticity developed by A. C. Eringen. It is assumed that the nano-structures under consideration have rectangular cross sections with piece wise constant dimensions and that the nanoplates are weakened with defects. The influence of the crack on the vibration of the nanoplate is assessed with the aid of additional local compliance developed in previous papers. Numerical results are presented for one- and two-stepped nanoplates.

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