Articoli di riviste: "N-256"

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Calvo, E., D. Escors, J. A. López, J. M. González, A. álvarez, E. Arza e L. Enjuanes. "Phosphorylation and subcellular localization of transmissible gastroenteritis virus nucleocapsid protein in infected cells". Journal of General Virology 86, n. 8 (1 agosto 2005): 2255–67. http://dx.doi.org/10.1099/vir.0.80975-0.

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The nucleocapsid (N) protein is the only phosphorylated structural protein of the coronavirus Transmissible gastroenteritis virus (TGEV). The phosphorylation state and intracellular distribution of TGEV N protein in infected cells were characterized by a combination of techniques including: (i) subcellular fractionation and analysis of tryptic peptides by two-dimensional nano-liquid chromatography, coupled to ion-trap mass spectrometry; (ii) tandem mass-spectrometry analysis of N protein resolved by SDS-PAGE; (iii) Western blotting using two specific antisera for phosphoserine-containing motifs; and (iv) confocal microscopy. A total of four N protein-derived phosphopeptides were detected in mitochondria–Golgi–endoplasmic reticulum–Golgi intermediate compartment (ERGIC)-enriched fractions, including N-protein phosphoserines 9, 156, 254 and 256. Confocal microscopy showed that the N protein found in mitochondria–Golgi–ERGIC fractions localized within the Golgi–ERGIC compartments and not with mitochondria. Phosphorylated N protein was also present in purified virions, containing at least phosphoserines 156 and 256. Coronavirus N proteins showed a conserved pattern of secondary structural elements, including six β-strands and four α-helices. Whilst serine 9 was present in a non-conserved domain, serines 156, 254 and 256 were localized close to highly conserved secondary structural elements within the central domain of coronavirus N proteins. Serine 156 was highly conserved, whereas no clear homologous sites were found for serines 254 and 256 for other coronavirus N proteins.

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Wright, D., e M. S. El‐Shall. "A Monte Carlo study of methanol clusters (CH3OH)N, N=5–256". Journal of Chemical Physics 105, n. 24 (22 dicembre 1996): 11199–208. http://dx.doi.org/10.1063/1.472919.

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Pasqualatto, D., M. Pachón, D. Rodríguez e M. Albarrán. "256 Treatment of mercury oxide intoxication with N-acetyl cysteine". Toxicology Letters 144 (settembre 2003): s71—s72. http://dx.doi.org/10.1016/s0378-4274(03)90255-4.

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P. C, Odukwe, Mbachu C. B., Ekengwu B. O. e Onebunne D. K. "Minimizing PAPR of OFDM Signal Using Discrete Cosine Transform and Log Companding". International Journal of Advanced Networking and Applications 14, n. 02 (2022): 5361–66. http://dx.doi.org/10.35444/ijana.2022.14206.

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This paper proposed precoding of OFDM signal using Discrete Cosine Transform (DCT) and adding of Log companding algorithm so as to reduce PAPR. Three scenarios were considered to fully examine the effect of PAPR in OFDM system based on simulations conducted in MATLAB environment while varying the number of subcarriers, N = 64 and 256. Initial simulation using conventional OFDM showed high PAPR in transmitted signal for N = 64 and 256, which resulted in PAPR of 9.741 and 11.41 dB respectively. In the second case, log companding technique was introduced into the OFDM and it was observed that PAPR was significantly reduced to 5.664 dB, and 6.101 dB by a percentage improvement of 41.9% and 46.5% for N = 64 and 256. For the proposed scheme, DCT scheme was used to initially precode the OFDM and a log companding algorithm applied, the results obtained indicated more than half level of reduction in PAPR of OFDM signal such that for N = 64 and 256 the PAPR was reduced to 4.214 dB and 4.743 dB, which corresponded to percentage improvement of 56.7% and 58.4% respectively.

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Office, Editorial. "Boekbespreking". HTS Teologiese Studies / Theological Studies 51, n. 1 (31 marzo 1995): 254–75. http://dx.doi.org/10.4102/hts.v51i1.5778.

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Van der Merwe, P.J. - Brown, S. 1994. The nearest in affection: Towards a Christian understanding of Islam. (Bladsy 254-255)Van der Merwe, P.J. - Newbigin, L. 1991. The gospel in a pluralist society. (Bladsy 255-256)Van der Merwe, P.J. - Van der Merwe, D.C.S. 'n Watermodel vir die kosmologie of God se twee boeke met spesiale verwysing na Gen 1:1-19 en die moderne kosmologie. (Bladsy 256-258)Van der Merwe, P.J. - Kritzinger, J.J. Saayman, W. On being witnesses. (Bladsy 258-259)Dreyer, T.F.J. - Pieterse, Hennie. Praktiese Teologie as kommunikatiewe handelingsteorie. (Bladsy 260-261)Boshoff, F.J. - Burger, C.W., Müller, B.A. Smit D.J. Riglyne vir prediking oor die Pastorale en Algemene Briewe (Woord teen die lig 11/6). (Bladsy 261-262)Du Toit, B.A. - Van Aarde, Andries. Kultuurhistoriese agtergrond van die Nuwe Testament: Die eerste-eeuse Mediterreense sosiale konteks. (Bladsy 263-264)Van der Merwe, Paul - Van der Westhuizen, H.G. Herder van Angola. (Bladsy 264-268)Beukes J.A. - Burger, C.W., Müller, B.A. Smit D.J. Riglyne vir prediking oor regverdiging en reg: Woord teen die lig 111/3. (Bladsy 260-270)Engelbrecht Johannes J. - Joubert, Stephan. Matteus vandag. (Bladsy 270-272)Botes H.J. - Celliers, Johan. God vir ons. (Bladsy 272-274)Pretorius, S.P. - Papp, Kálmán. Die Nederduitsch Hervormde Gemeente Krugersdorp 1891 - 1991. (Bladsy 274-275)

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Terpstra, S., L. A. Van de Stadt, A. Boonen, F. Rosendaal e M. Kloppenburg. "POS1368 THE LONGITUDINAL ASSOCIATION OF HAND OA WITH PAID AND UNPAID WORK IMPAIRMENT AND RELATED COSTS: THE HOSTAS COHORT". Annals of the Rheumatic Diseases 82, Suppl 1 (30 maggio 2023): 1036.2–1037. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3538.

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BackgroundHand osteoarthritis (OA) is associated with impairment in paid and unpaid work and contributes to societal burden and costs of OA. However, the longitudinal development of hand OA-related work impairment and related societal costs are unknown.ObjectivesTo investigate the association of hand OA with paid and unpaid work productivity loss, hinder and societal costs longitudinally.MethodsWe used annual data of the Dutch Hand OSTeoArthritis in Secondary care (HOSTAS) cohort, consisting of patients with primary hand OA primary hand OA defined by the treating rheumatologist. Data from baseline to four years of follow-up was used. The Health and Labour Questionnaire (HLQ) was assessed over the last two weeks on (i) hand OA-related limitations and hours of productivity loss while at work, (ii) hours of sick leave, and (iii) limitations and hours of unpaid work replacement. Patients with HLQ data on >1 timepoint were included in this study.Societal costs of paid work productivity loss (=all hourly costs in order to employ a worker, such as salary and premiums) were estimated by multiplying the number of unproductive and sick leave hours due to hand OA by the estimated hourly costs of paid work in The Netherlands based on age and sex. Costs of unpaid work were estimated by multiplying the hours of unpaid work replaced by others by the Dutch gross average hourly salary of a household help (2021:€12.50). Costs were adjusted to 2021 values using conversion factors provided by the Dutch government, and to yearly values.Results470 patients had data on more than one timepoint. Baseline data was available for 381 patients, of whom 256 patients (67%) completed four years of follow-up, and 215 (56%) completed all five follow-up moments.Of 256 patients with baseline and four years follow-up, 113 (52%) had paid work at baseline and 104 (41%) at four years (Table1 for patient characteristics). Unproductive hours at any timepoint were present for 85/470 patients (18%), for whom unproductive hours fluctuated over time (Figure 1). Median paid work hinder score (score range: 6-24) remained stable at 7 (interquartile range (IQR): 6;8) over the study period. Unproductive hours at any timepoint were present for 85/470 patients (18%).Regarding unpaid work, 105/256 (41%) required unpaid task replacement by others due to hand OA at baseline, which remained stable over time (108/256 at four years (42%)). Unpaid work hinder was reported by 100/256 patients (39%) at baseline and 97/256 (36%) at four years.Costs related to loss of paid and unpaid productivity were incurred at baseline by 136/256 patients, with a median of €63 per patient ((IQR) 38;125) per two weeks (€1630 per patient (978;3261 per year). At four years, these costs were present for 120/256 patients, with a median of €50 (38;100) per two weeks (€1304 (978;2609) per year).ConclusionPatients with hand OA experience significant impairment in paid and unpaid work participation over the years, which translates into substantial societal costs. Impairment and costs fluctuate on individual level but seem to remain stable over four years on group level.Table 1.Demographics and hand OA characteristics of patients with at least baseline and four years of follow-up data.baseline, all patients (n=256)baseline, paid work (133/255, 52%)four years, all patients (n=256)four years, paid work (104/255, 41%)Age, years61.3 (8.0)60.2 (7.5)64.6 (8.4)62.0 (8.1)Sex, women,n (%)204 (80%)108 (82%)204 (80%)87 (84%)BMI, kg/m227.3 (4.7)27.2 (4.7)27.4 (5.0)27.1 (4.7)AUSCAN hand pain (0-20)9 (4.3)9.1 (4.6)9.3 (4.3)7.9 (4.5)AUSCAN hand function (0-36)15.1 (8.4)14.6 (8.5)15.2 (8.4)14.5 (7.7)HADS anxiety score (range 0-21)^4 (2;6)4 (2;6)4 (2;6)3 (2;6)HADS depression score (range 0-21)^2 (1;5)2 (1;4)2 (1;5)1 (1;4)Retired,n (%)83 (32%)-95 (37%)-Numbers represent (SD) mean unless otherwise specified. ^median (interquartile range). Abbreviations: SD = standard deviation, BMI = Body Mass Index, HADS = Hospital Anxiety and Depression Scale, AUSCAN = Australian Canadian Osteoarthritis Hand Index.REFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsSietse Terpstra: None declared, Lotte A. van de Stadt: None declared, Annelies Boonen: None declared, Frits Rosendaal: None declared, Margreet Kloppenburg Grant/research support from: Received funding for the HOSTAS cohort, all paid to the institution.

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Achebe, P. N. "Minimizing Peak to Average Power Ratio in OFDM System with WHT and Log Companding". International Journal of Advanced Networking and Applications 14, n. 02 (2022): 5329–33. http://dx.doi.org/10.35444/ijana.2022.14202.

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Orthogonal Frequency Division Multiplexing (OFDM) suffers the effect of Peak to Average Power Ratio (PAPR) that reduces the strength or power of radio frequency (RF) signal at the transmitter and which also pushes the performance of transmitter amplifier into distortion. In order to minimize the effect of PAPR in OFDM, this paper proposed a system that precodes the OFDM signal using Walsh-Hadamard Transform (WHT) and Log function companding algorithm. Simulations were conducted in MATLAB environment while varying the number of subcarriers, N = 16, 64, 128, 256. simulation results indicated original OFDM revealed high PAPR in transmitted signal for the different number of subcarriers (N) such that for N =16, 64, 128, and 256, resulting in 7.964dB, 8.885 dB, 9.548 dB, and 9.961 dB respectively. With the introduction of WHT-Log companding scheme, the PAPR of OFDM signal was significantly reduced to 4.775 dB, 4.285 dB, 4.517 dB, and 4.602 dB by a percentage improvement of 40%, 51.8%, 52.7%, and 57.8% for N = 16, 64, 128, and 256 respectively. As a result, from the simulation results, the proposed system can be said to have largely reduced PAPR in OFDM system using a scheme with significant computational complexity.

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Thomas, Juliette, Etienne Guillaud, Edouard Courtin, Emilie Doat, Pierre Burbaud e Dominique Guehl. "N°256 – Kinematic analysis of movement to assess GPi-DBS effectiveness in dystonia". Clinical Neurophysiology 150 (giugno 2023): e154. http://dx.doi.org/10.1016/j.clinph.2023.03.245.

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Lozniewski, A., R. Labia, X. Haristoy e F. Mory. "Antimicrobial Susceptibilities of ClinicalDesulfovibrio Isolates". Antimicrobial Agents and Chemotherapy 45, n. 10 (1 ottobre 2001): 2933–35. http://dx.doi.org/10.1128/aac.45.10.2933-2935.2001.

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ABSTRACT The antimicrobial susceptibilities of 16 clinical isolates ofDesulfovibrio spp. were determined. All or most isolates were susceptible to imipenem (MIC90 [MIC at which 90% of the isolates tested were inhibited], 0.5 μg/ml), metronidazole (MIC90, 0.25 μg/ml), clindamycin (MIC90, 4 μg/ml), and chloramphenicol (MIC90, 16 μg/ml) but were resistant or intermediate to penicillin G (MIC90, 64 μg/ml), piperacillin (MIC90, 256 μg/ml), piperacillin-tazobactam (MIC90, 256 μg/ml), cefoxitin (MIC90, >256 μg/ml), and cefotetan (MIC90, 64 μg/ml). Among isolates with decreased susceptibility to β-lactams (n = 15), only six were β-lactamase positive and susceptible to amoxicillin-clavulanate and ticarcillin-clavulanate.

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Draine, B. T. "Sensitivity of Polarization to Grain Shape. II. Aggregates". Astrophysical Journal 969, n. 2 (1 luglio 2024): 92. http://dx.doi.org/10.3847/1538-4357/ad3b9a.

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Abstract A previous study (Paper I) investigated the polarization properties of a variety of simple convex grain shapes, some of which were found to be consistent with the observed polarization properties of interstellar dust from far-ultraviolet to far-infrared. Here, we study the optical properties of 45 nonconvex shapes, all aggregates of N equal-sized spheres. We consider N = 2, N = 3, and N = 256 random aggregates obtained from three different aggregation schemes. We also consider “trimmed” N = 256 aggregates obtained by systematically trimming initially random aggregates to increase either flattening or elongation. The “macroporosities” of the studied aggregates range from P macro = 0.18 (for the N = 2 bisphere) to P macro ≈ 0.85 (for the N = 256 “BA” aggregates). The only aggregates consistent with observations of starlight polarization and polarized thermal emission are shapes that have been trimmed to increase their asymmetry. If interstellar grains are high-porosity aggregates, there must be processes causing extreme elongation or flattening; if not, interstellar grains must be dominated by fairly compact structures, with at most moderate porosities. The ratio of polarization in the 10 μm silicate feature to starlight polarization in the optical is shown to be insensitive to porosity and shape. X-ray scattering may be the best tool to determine the porosity of interstellar grains. We propose that modest porosities of interstellar grains could be the result of “photolytic densification.” High polarization fractions observed in some Class 0 cores require processes to reduce porosities and/or increase asymmetries of aggregates in dense regions.

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McDermott, Katherine A., Kristin Fitch, Kirsten H. Dillon, Nora E. Mueller, Corinne N. Carlton, Norman B. Schmidt e Jesse R. Cougle. "Development of the Response to Fearful Situations Scale". Behavioural and Cognitive Psychotherapy 48, n. 6 (28 luglio 2020): 688–704. http://dx.doi.org/10.1017/s1352465820000466.

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AbstractBackground:Most measures of anxious avoidance are limited to disorder-specific mechanisms and ignore the measurement of courage/approach responding in confronting fearful situations.Aims:The purpose of the present study was to construct and validate a self-report assessment of the tendency towards avoidant or approach responding in fearful situations, the Response to Fearful Situations Scale (RFSS).Method and Results:In Study 1 (n = 241), exploratory factor analysis resulted in two factors, avoidance and approach. Study 2 (n = 423) replicated the two-factor structure and established test–re-test reliability. In Study 3 (n = 44), the RFSS demonstrated predictive validity on a behavioural avoidance task. In Studies 4 (n = 253) and 5 (n = 256), the RFSS was associated with clinical symptoms above existing measures of avoidance.Discussion:These results validate the use of the RFSS as a transdiagnostic measure of avoidance and approach.

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Loke, Paxton, e Tiow-Suan Sim. "Mutational analysis of conserved glycines 42 and 256 in Cephalosporium acremonium isopenicillin N synthase". Canadian Journal of Microbiology 47, n. 10 (1 ottobre 2001): 961–64. http://dx.doi.org/10.1139/w01-101.

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Isopenicillin N synthase (IPNS) is critical for the catalytic conversion of δ -(L-α-aminoadipoyl)-L-cysteinyl-D-valine to isopenicillin N in the penicillin and cephalosporin biosynthetic pathway. Two conserved glycine residues in Cephalosporium acremonium IPNS (cIPNS), namely glycine-42 and glycine-256, were identified by multiple sequence alignment and investigated by site-directed mutagenesis to study the effect of the substitution on catalysis. Our study showed that both the mutations from glycine to alanine or to serine reduced the catalytic activity of cIPNS and affected its soluble expression in a heterologous host at 37°C. Soluble expression was restored at a reduced temperature of 25°C, and thus, it is possible that these glycine residues may have a role in maintaining the local protein structure and are critical for the soluble expression of cIPNS.Key words: isopenicillin N synthase, site-directed mutagenesis, glycine, Cephalosporium acremonium.

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Diethelm, Marie-Bénédicte. "« L’Indispensable visite », Orages , sous la direction d’Olivier Guichard, n°8, mars 2009, 256 p." Romantisme 153, n. 3 (1 settembre 2011): XIV. http://dx.doi.org/10.3917/rom.153.0169n.

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Kulbachinsky, N. V., T. V. Brailovskaya e B. Ya Bart. "Possibility of determining patients with chronic obstructive pulmonary disease at ambulatory treatment by dentist". Medical alphabet 3, n. 23 (21 novembre 2019): 51–54. http://dx.doi.org/10.33667/2078-5631-2019-3-23(398)-51-54.

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Detection of persons suffering from chronic obstructive pulmonary disease was carried out among patients who received scheduled and urgent surgical dental care on an outpatient dental appointment. At the first stage, a questionnaire was conducted for patients with dentition defects that needed orthopedic treatment, and patients who planned surgical manipulations with subsequent planned prosthetics, including those based on intraosseous implants. Patients with previously verified COPD, clinical signs of the disease (respiratory symptoms) and a high probability of its presence were sent to the physician-therapist for targeted standardized screening and diagnosis clarification. 978 patients were questioned, 256 patients were identified, subject to targeted standardized screening. COPD was verified in 95 patients (n = 95), which was 9,7 % of the total number of questionnaires (n = 978) and 37 % of the number of patients who underwent targeted screening (n = 256).

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Choi, Sol-lim, Hyun-Sung Kim, Jae-Hwan Choi e Eun Hye Oh. "The Head-Bending Test in Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo". Research in Vestibular Science 21, n. 4 (15 dicembre 2022): 99–103. http://dx.doi.org/10.21790/rvs.2022.21.4.99.

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Objectives: This study aimed to investigate clinical significance of a head-bending test in benign paroxysmal positional vertigo (BPPV) involving the posterior semicircular canal (PC-BPPV).Methods: We retrospectively recruited 256 patients with unilateral PC-BPPV between January 2016 and December 2021, and assessed the clinical characteristics of patients showing head-bending nystagmus (HBN).Results: Of 256 patients, 138 (53.9%) showed HBN. Most patients (n=136, 98.6%) had downbeat nystagmus with (n=38) or without (n=98) torsional component. The remaining two patients had pure upbeat and torsional nystagmus, respectively. The torsional component was directed to the contralesional side in all. Between patients with and without HBN, there were no significant differences in clinical characteristics such as age, lateralization, types of BPPV (canalolithiasis or cupulolithiasis), and success rate of repositioning maneuver.Conclusions: Head-bending test may be useful in predicting the diagnosis and lateralization of PC-BPPV.

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Ho, Ming-Chih, Ching-Hsi Hsiao, Ming-Hui Sun, Yih-Shiou Hwang, Chi-Chun Lai, Wei-Chi Wu e Kuan-Jen Chen. "Antimicrobial Susceptibility, Minimum Inhibitory Concentrations, and Clinical Profiles of Stenotrophomonas maltophilia Endophthalmitis". Microorganisms 9, n. 9 (30 agosto 2021): 1840. http://dx.doi.org/10.3390/microorganisms9091840.

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Stenotrophomonas maltophilia has been reported in various ocular infections, including keratitis, conjunctivitis, preseptal cellulitis, and endophthalmitis, all of which may lead to vision loss. However, the S. maltophilia strain is resistant to a wide variety of antibiotics, including penicillins, third-generation cephalosporins, aminoglycosides, and imipenem. In this study, we retrospectively reviewed the clinical characteristics, antibiotic susceptibility, antimicrobial minimum inhibitory concentrations (MICs), and visual outcomes for S. maltophilia endophthalmitis. The data of 9 patients with positive S. maltophilia cultures in a tertiary referral center from 2010 to 2019 were reviewed. Cataract surgery (n = 8, 89%) was the most common etiology, followed by intravitreal injection (n = 1, 11%). S. maltophilia’s susceptibility to levofloxacin and moxifloxacin was observed in 6 cases (67%). Seven isolates were resistant to sulfamethoxazole-trimethoprim (78%). The MIC90 for S. maltophilia was 256, 256, 256, 8, 12, 12, 12, and 8 μg/mL for amikacin, cefuroxime, ceftazidime, tigecycline, sulfamethoxazole-trimethoprim, levofloxacin, galtifloxacin, and moxifloxacin, respectively. Final visual acuity was 20/200 or better in 5 patients (56%). Fluoroquinolones and tigecycline exhibited low antibiotic MIC90. Therefore, the results suggest that fluoroquinolones can be used as first-line antibiotics for S. maltophilia endophthalmitis.

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Lind, D. A. "Charge-exchange studies at the Los Alamos Meson Physics Facility – Weapon Neutron Research Facility". Canadian Journal of Physics 65, n. 6 (1 giugno 1987): 637–42. http://dx.doi.org/10.1139/p87-090.

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The Los Alamos Meson Physics Facility – Weapon Neutron Research Facility has been used for (p,n) charge-exchange studies leading to a paper on the energy dependence of the nucleon–nucleon spin–isospin interaction at up to 800 MeV. Because of program changes connected with the use of the proton storage ring and the need for a "white" neutron source, a new facility for neutron time-of-flight studies of the (p,n) reaction up to 800 MeV has been designed. In addition, a proposed facility using the white source for (n,p) studies up to 200 MeV is being built. A brief discussion of the results achieved thus far from the (p,n) work is given. Specific plans for the (p,n) facility with a flight path of 250 m, as well as the design for the proposed (n,p) white source, are discussed. Initial results with the (p,n) line at 256, 600, and 880 MeV show that the time spread due to proton-drift distance results in roughly constant neutron resolution.

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Rohrbasser, Jean-Marc. "Dubert Isidro (dir.), 2014, « Démographie des dictatures », Annales de démographie historique, n° 2, 256 p." Population 72, n. 1 (2017): 173. http://dx.doi.org/10.3917/popu.1701.0173.

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Sagara, Shuichiro, Kenji Sadamatsu, Yasuki Isa, Kazuhiro Nagaoka, Tomoki Shikada, Kensuke Ooe, Kunio Morishige et al. "AS-256: Preventive Effect of N-Acetylcysteine in Contrast-Induced Nephropathy during Elective Coronary Intervention". American Journal of Cardiology 103, n. 9 (aprile 2009): 108B. http://dx.doi.org/10.1016/j.amjcard.2009.01.312.

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Saraiva, Felipe Martins, José Carlos Batista Dubeux, Márcio Vieira da Cunha, Rômulo Simões Cezar Menezes, Mércia Virginia Ferreira dos Santos, Dayanne Camelo e Ivan Ferraz. "Manure Source and Cropping System Affect Nutrient Uptake by Cactus (Nopalea cochenillifera Salm Dyck)". Agronomy 11, n. 8 (29 luglio 2021): 1512. http://dx.doi.org/10.3390/agronomy11081512.

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Forage cactus responds positively to organic fertilization. However, little is known about the mineralization dynamics of the various sources of existing organic fertilizers. Thus, the objective was to evaluate the release of nutrients from different manure types and the nutrient accumulation in forage cactus across different cropping systems. Different manure sources (cattle, goat, sheep, and broiler litter) were evaluated for the following cropping systems: (i) Gliricidia sepium intercropped with cactus cv. IPA-Sertânia; (ii) Leucaena leucocephala intercropped with cactus cv. IPA-Sertânia; and (iii) Cactus cv. IPA-Sertânia in monoculture, in the tropical semiarid region of Brazil. The rate of decomposition and release of N, P, and K from manure was determined by incubating a litterbag, evaluated in different periods (0, 4, 8, 16, 32, 64, 128, and 256 days). Broiler litter released the greatest amount of N and P. Sheep manure released the greatest amounts of K. The greatest accumulations of N, P, and K in cactus biomass occurred when broiler litter was applied. Cactus monoculture accumulated less N over 256 days, indicating that the presence of tree legumes favors the accumulation of N in cactus. Broiler litter promoted the best synchronism between N release and N uptake in different cropping systems.

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DUJELLA, ANDREJ. "On the size of Diophantine m-tuples". Mathematical Proceedings of the Cambridge Philosophical Society 132, n. 1 (gennaio 2002): 23–33. http://dx.doi.org/10.1017/s0305004101005515.

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Let n be a nonzero integer. A set of m positive integers {a1, a2, …, am} is said to have the property D(n) if aiaj+n is a perfect square for all 1 [les ] i [les ] j [les ] m. Such a set is called a Diophantine m-tuple (with the property D(n)), or Pn-set of size m.Diophantus found the quadruple {1, 33, 68, 105} with the property D(256). The first Diophantine quadruple with the property D(1), the set {1, 3, 8, 120}, was found by Fermat (see [8, 9]). Baker and Davenport [3] proved that this Fermat’s set cannot be extended to the Diophantine quintuple, and a famous conjecture is that there does not exist a Diophantine quintuple with the property D(1). The theorem of Baker and Davenport has been recently generalized to several parametric families of quadruples [12, 14, 16], but the conjecture is still unproved.On the other hand, there are examples of Diophantine quintuples and sextuples like {1, 33, 105, 320, 18240} with the property D(256) [11] and {99, 315, 9920, 32768, 44460, 19534284} with the property D(2985984) [19]].

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Wu, Kuang Shyr, e Tsung Ming Lo. "An Efficient Secret Image Sharing Scheme". Applied Mechanics and Materials 284-287 (gennaio 2013): 3025–29. http://dx.doi.org/10.4028/www.scientific.net/amm.284-287.3025.

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This paper refers to a novel (r, n)-threshold secret image sharing scheme with low information overhead. The secret image is encoded into n noise-like shadow images in such a way that any r of the n shares can be used to reveal the secret, and no information about the secret can be revealed from any r–1 or fewer shares. The size of the shadow images is relatively small. Compared with the commonly used in the field of secret image sharing “Thien-Lin algorithm (2002),” the proposed scheme provides an alternative solution for light images. For the security analysis in the case of a 256x256 gray level secret image, if a hacker acquires any r – 1 shadow images, the hacker can construct only r – 1 equations, then the possibility of guessing the right solution is only 1/256. Hence, there are (256x256)/r polynomials, the possibility of obtaining the right image is only (1/256) (256x256)/r. The experimental results and theoretically analysis demonstrate that the proposed scheme performs well.

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Joseph Raj, Alex Noel, Lianhong Cai, Wei Li, Zhemin Zhuang e Tardi Tjahjadi. "FPGA-based systolic deconvolution architecture for upsampling". PeerJ Computer Science 8 (11 maggio 2022): e973. http://dx.doi.org/10.7717/peerj-cs.973.

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A deconvolution accelerator is proposed to upsample n × n input to 2n × 2n output by convolving with a k × k kernel. Its architecture avoids the need for insertion and padding of zeros and thus eliminates the redundant computations to achieve high resource efficiency with reduced number of multipliers and adders. The architecture is systolic and governed by a reference clock, enabling the sequential placement of the module to represent a pipelined decoder framework. The proposed accelerator is implemented on a Xilinx XC7Z020 platform, and achieves a performance of 3.641 giga operations per second (GOPS) with resource efficiency of 0.135 GOPS/DSP for upsampling 32 × 32 input to 256 × 256 output using a 3 × 3 kernel at 200 MHz. Furthermore, its high peak signal to noise ratio of almost 80 dB illustrates that the upsampled outputs of the bit truncated accelerator are comparable to IEEE double precision results.

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Bielecka, Magdalena K., Nathalie Devos, Mélanie Gilbert, Miao-Chiu Hung, Vincent Weynants, John E. Heckels e Myron Christodoulides. "Recombinant Protein Truncation Strategy for Inducing Bactericidal Antibodies to the Macrophage Infectivity Potentiator Protein of Neisseria meningitidis and Circumventing Potential Cross-Reactivity with Human FK506-Binding Proteins". Infection and Immunity 83, n. 2 (1 dicembre 2014): 730–42. http://dx.doi.org/10.1128/iai.01815-14.

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A recombinant macrophage infectivity potentiator (rMIP) protein ofNeisseria meningitidisinduces significant serum bactericidal antibody production in mice and is a candidate meningococcal vaccine antigen. However, bioinformatics analysis of MIP showed some amino acid sequence similarity to human FK506-binding proteins (FKBPs) in residues 166 to 252 located in the globular domain of the protein. To circumvent the potential concern over generating antibodies that could recognize human proteins, we immunized mice with recombinant truncated type I rMIP proteins that lacked the globular domain and the signal leader peptide (LP) signal sequence (amino acids 1 to 22) and contained the His purification tag at either the N or C terminus (C-term). The immunogenicity of truncated rMIP proteins was compared to that of full (i.e., full-length) rMIP proteins (containing the globular domain) with either an N- or C-terminal His tag and with or without the LP sequence. By comparing the functional murine antibody responses to these various constructs, we determined that C-term His truncated rMIP (−LP) delivered in liposomes induced high levels of antibodies that bound to the surface of wild-type but not Δmipmutant meningococci and showed bactericidal activity against homologous type I MIP (median titers of 128 to 256) and heterologous type II and III (median titers of 256 to 512) strains, thereby providing at least 82% serogroup B strain coverage. In contrast, in constructs lacking the LP, placement of the His tag at the N terminus appeared to abrogate bactericidal activity. The strategy used in this study would obviate any potential concerns regarding the use of MIP antigens for inclusion in bacterial vaccines.

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A. Abdul Kareem, Mo A. AL-Mazini, T. Bukeet, and. "Comparison of recoveries of Mycobacterium tuberculosis using the automated BACTEC MGIT 960 System and Lowenstein – Jensen medium". Al-Qadisiyah Journal of Veterinary Medicine Sciences 9, n. 1 (20 giugno 2010): 44. http://dx.doi.org/10.29079/vol9iss1art92.

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We examined whether the BACTEC/ Mycobacteria Growth Indicator Tube (MGIT) System alone could supplant the use of a supplemental Lowenstein–Jensen (LJ) slant for routine recovery of M. tuberculosis from clinical specimens. A total of 392 specimens of sputum were included in the study, collected from 196 patients. Specimens were processed with standard N-acetyl- L- Cysteine (NALC-NaOH) method, then inoculated onto BACTEC MGIT 960 and onto LJ media. The recovery rates of M.tuberculosis were 100 % (256/256) with BACTEC MGIT 960 and 72.6%(186/256) with LJ. The rates of contamination for each of the system were 4.8%with BACTEC MGIT 960 and 5.3%with LJ. The TTD for M. tuberculosis was 11.3 days with BACTEC System and 30.8 days with LJ. The difference in TTD between smear positive and smear negative specimens for M.tuberculosis with BACTEC MGIT 960 was not statistically significant. This study shows that the BACTEC System demonstrates better sensitivity for the recovery of M. tuberculosis from clinical specimens.

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Loke, Paxton, e Tiow-Suan Sim. "Mutational analysis of conserved glycines 42 and 256 in Cephalosporium acremonium isopenicillin N synthase". Canadian Journal of Microbiology 47, n. 10 (2001): 961–64. http://dx.doi.org/10.1139/cjm-47-10-961.

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27

Liu, Jiajia, e Weiping Zheng. "Cyclic peptide-based potent human SIRT6 inhibitors". Organic & Biomolecular Chemistry 14, n. 25 (2016): 5928–35. http://dx.doi.org/10.1039/c5ob02339d.

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Abstract (sommario):

Six side chain-to-side chain cyclic pentapeptides (4–9) harboring a central N^ε-dodecyl (or tetradecyl)-thiocarbamoyl-lysine residue all behaved as highly potent (IC₅₀ ∼ 256–495 nM) inhibitors against human SIRT6-catalyzed deacylation reaction.

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28

Holtås, S. L., D. B. Plewes, J. H. Simon, S. Ekholm, D. K. Kido e R. Utz. "Technical Aspects on Magnetic Resonance Imaging of the Spine at 1.5 Tesla". Acta Radiologica 28, n. 4 (luglio 1987): 375–81. http://dx.doi.org/10.1177/028418518702800402.

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Abstract (sommario):

Technical aspects on surface coil magnetic resonance imaging of the spine using a superconducting system with a field strength of 1.5 tesla are described. By using a flat surface coil instead of the body coil the image quality was markedly improved and the signal-to-noise ratio (S/N) was increased approximately 2.6 times. Small voxels resulted in low S/N. The best image quality was achieved with a slice thickness of 5 mm, a field of view of 20 to 24 cm and a matrix of 256×256. Interleaved slices provided superior image quality compared with contiguous slices at the expense of acquisition time. For sagittal images the phase encoding gradient should be in the cranio-caudal direction to minimize motion artifacts. To obtain T1 and T2 images of high quality, spin echo pulse sequences with TR 600/TE 20 ms and TR 2000/TE 40 to 80 ms are useful.

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Yu, Long, Lintao Liu, Zhe Xia, Xuehu Yan e Yuliang Lu. "Lossless and Efficient Secret Image Sharing Based on Matrix Theory Modulo 256". Mathematics 8, n. 6 (22 giugno 2020): 1018. http://dx.doi.org/10.3390/math8061018.

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Most of today’s secret image sharing (SIS) schemes are based on Shamir’s polynomial-based secret sharing (SS), which cannot recover pixels larger than 250. Many exiting methods of lossless recovery are not perfect, because several problems arise, such as large computational costs, pixel expansion and uneven pixel distribution of shadow image. In order to solve these problems and achieve perfect lossless recovery and efficiency, we propose a scheme based on matrix theory modulo 256, which satisfies ( k , k ) and ( k , k + 1 ) thresholds. Firstly, a sharing matrix is generated by the filter operation, which is used to encrypt the secret image into n shadow images, and then the secret image can be obtained by matrix inverse and matrix multiplication with k or more shadows in the recovery phase. Both theoretical analyses and experiments are conducted to demonstrate the effectiveness of the proposed scheme.

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30

Dimitrova, Maya, Min Jae Kim, Douglas M. Donnelly, Keith M. Giles, Una Moran, Jeffrey S. Weber, Iman Osman e George Jour. "Lack of evidence to support large-panel genomic testing in treatment selection for malignant melanoma." Journal of Clinical Oncology 38, n. 15_suppl (20 maggio 2020): e22027-e22027. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e22027.

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e22027 Background: Genomic profiling informs clinical decision-making for malignant melanoma (MM) as specific tumor mutations can be treated with targeted therapy (TT). However, given the range of different panel sizes available and increasing use of immune checkpoint inhibitors (ICI), the clinical significance of upfront, large-panel genomic profiling in MM remains undetermined. Herein, we investigate the impact of panel size and targetable mutational status on first-line treatment selection and outcomes of MM patients from 9 different institutions. Methods: We analyzed data for 1,341 MM patients from 3 cohorts. Cohort 1 included 169 patients enrolled at NYULH and profiled with the 50 gene Ion Torrent panel (IT). Cohort 2 included 256 patients enrolled at MSKCC, profiled with the 400-gene MSK-IMPACT panel (MSK-I). Cohort 3 included 916 patients enrolled at 7 different sites, profiled with whole exome sequencing (WES). Data for cohorts 2 and 3 were extrapolated from publicly available data using cBioPortal. We tested associations between molecular data, treatment choice and overall survival (OS), adjusting for baseline characteristics when available. Results: Treatment information was available for 100%, 25%, and 0% of patients in cohort 1, 2 and 3, respectively. Stage was available for all of cohort 1 (III, n = 68; IV, n = 101) and cohort 2 (III, n = 2; IV, n = 254), but in only 23% of cohort 3 (III, n = 184; IV n = 25). For the IT and MSK-I, BRAF and NRAS were among the top 5 most commonly mutated genes, whereas for WES only BRAF was in the top 5. In cohort 1, 36% (16/45) of BRAF MUT patients received first-line TT vs 25% (66/256) in cohort 2. There was no significant difference for BRAF MUT patients treated with ICI vs. TT in cohort 1 in OS (P = 0.19), nor for BRAF MUT patients from cohort 1 treated with ICI vs. those from cohort 2 treated with TT (OS P = 0.762). Conclusions: Publicly available datasets provide population-level data, however the heterogeneity and deficiency of reported clinical information limits their value and calls for data standardization. Without evidence of clear clinical benefit of a larger panel size, there is a rationale for adopting smaller, more cost effective panels in MM.

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Nicholson, William L., Susie Muir, John W. Sumner e James E. Childs. "Serologic Evidence of Infection with Ehrlichia spp. in Wild Rodents (Muridae: Sigmodontinae) in the United States". Journal of Clinical Microbiology 36, n. 3 (1998): 695–700. http://dx.doi.org/10.1128/jcm.36.3.695-700.1998.

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Abstract (sommario):

Rodent (Muridae: Sigmodontinae) blood and sera collected from 14 states were tested for seroreactivity to a cultured isolate of the human granulocytic ehrlichiosis (HGE) agent by using an indirect immunofluorescence assay. Of the 1,240 samples tested, 136 (11%) were found to be reactive at titers of ≥32. Rodents with HGE agent-specific antibodies were found in New York (23% of 491 samples; geometric mean endpoint titer [GMT] = 441), Connecticut (11% of 100 samples; GMT = 481), California (9% of 32 samples; GMT = 323), Colorado (2% of 212 samples; GMT = 256), Florida (7% of 27 samples; GMT = 362), Maryland (7% of 15 samples; titer = 64), New Jersey (4% of 76 samples; titer = 256), and Wisconsin (13% of 8 samples; titer = 128). Samples from Georgia (n = 16), Illinois (n = 27), Nevada (n = 27), North Carolina (n = 52), Ohio (n = 57), and Utah (n = 100) were not reactive. The earliest seroreactive sample was from aPeromyscus leucopus mouse collected in June 1986 in Connecticut, and the majority of the seroreactive samples (68%) were from this species. Samples from other Peromyscus species (P. boylii, P. maniculatus, and P. gossypinus) were also found to be reactive, with a GMT for the genus of 410. Several species of Neotoma woodrats (N. fuscipes, N. lepida, N. albigula, and N. mexicana) from California and Colorado had antibodies that reacted with the HGE agent (genus GMT = 194), suggesting that enzootic cycles of Ehrlichia spp. exist outside of the areas of confirmed human disease. Attempts to amplify and detect ehrlichial DNA from the limited tissues available (n = 40 animals) were unsuccessful. Further studies are needed to determine the identity of the organisms inducing antibody production in these rodent species and to elucidate the epidemiology and public health importance of these agents.

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Cid Villagrasa, Blanca. "La Corte Constitucional italiana y el Tribunal de Justicia de la Unión Europea: Europeización del Derecho constitucional nacional o nacionalización del Derecho europeo". Asamblea. Revista parlamentaria de la Asamblea de Madrid, n. 28 (30 giugno 2013): 331–62. http://dx.doi.org/10.59991/rvam/2013/n.28/256.

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Sumario: I. INTRODUCCIÓN.—II. EVOLUCIÓN HISTÓRICA DE LA JURISPRUDENCIA DE LA CORTE CONSTITUCIONAL ITALIANA.—2.1. Lex posterior abrogat priori y Costa c. Enel.—2.2. Frontini y Spa Simmenthal.—2.3. Granital y Fragd.—2.4. Francovich y otros.—2.5. Reforma, Lisboa y prejudicialidad.—2.6. Convenio y Carta.—III. CONCLUSIONES: LOS CONTRA LÍMITES.

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Macey, David A. J. "Krest'ianskaia obshchina evropeiskoi Rossii, 1907-1914 gg. By P. N. Zyrianov. Moscow: Nauka, 1992. 256 pp. Paper." Slavic Review 52, n. 4 (1993): 906–7. http://dx.doi.org/10.2307/2499702.

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34

Hchicha, Khouloud, Marcus Korb, Riadh Badraoui e Houcine Naïli. "A novel sulfate-bridged binuclear copper(ii) complex: structure, optical, ADMET and in vivo approach in a murine model of bone metastasis". New Journal of Chemistry 45, n. 31 (2021): 13775–84. http://dx.doi.org/10.1039/d1nj02388h.

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A novel complex, formulated as [Cu₂(μ₃-SO₄)₂(C₄H₆N₂)₄], showed significant ameliorative effects on tumor osteolytic lesions in malignant Walker 256/B breast cancer-induced bone metastases.

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35

Huang, Penghe, Dongyan Li, Yu Wang, Huimin Zhao e Wu Deng. "A Novel Color Image Encryption Algorithm Using Coupled Map Lattice with Polymorphic Mapping". Electronics 11, n. 21 (24 ottobre 2022): 3436. http://dx.doi.org/10.3390/electronics11213436.

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Some typical security algorithms such as SHA, MD4, MD5, etc. have been cracked in recent years. However, these algorithms have some shortcomings. Therefore, the traditional one-dimensional-mapping coupled lattice is improved by using the idea of polymorphism in this paper, and a polymorphic mapping–coupled map lattice with information entropy is developed for encrypting color images. Firstly, we extend a diffusion matrix with the original 4 × 4 matrix into an n × n matrix. Then, the Huffman idea is employed to propose a new pixel-level substitution method, which is applied to replace the grey degree value. We employ the idea of polymorphism and select f(x) in the spatiotemporal chaotic system. The pseudo-random sequence is more diversified and the sequence is homogenized. Finally, three plaintext color images of 256×256×3, “Lena”, “Peppers” and “Mandrill”, are selected in order to prove the effectiveness of the proposed algorithm. The experimental results show that the proposed algorithm has a large key space, better sensitivity to keys and plaintext images, and a better encryption effect.

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Leliqia, Ni Putu Eka, Elin Yulinah Sukandar e Irda Fidrianny. "ANTIBACTERIAL ACTIVITIES OF ANREDERA CORDIFOLIA (TEN.) V. STEENIS LEAVES EXTRACTS AND FRACTIONS". Asian Journal of Pharmaceutical and Clinical Research 10, n. 12 (1 dicembre 2017): 175. http://dx.doi.org/10.22159/ajpcr.2017.v10i12.21503.

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Objective: This study aims to determine antibacterial activity of Anredera cordifolia leaves extracts and fractions.Methods: Crude drug was extracted using two methods. First method was extraction by reflux using ethanol 96% and then fractionated by liquid-liquid extraction using n-hexane and ethyl acetate. Second method was gradually extraction by reflux using n-hexane, ethyl acetate and ethanol 96%, respectively. Phytochemical screening was applied to all extracts and fractions, followed by thin-layer chromatography using ursolic acid, oleanolic acid (OA), apigetrin, and rutin as reference substances. A two-fold serial microdilution method was used to determine minimum inhibitory concentration (MIC) against Staphylococcus aureus (ATCC 6538), methicillin-susceptible S. aureus, methicillin resistant S. aureus (MRSA), Bacillus subtilis (ATCC 6633), Bacillus cereus (ATCC 11778), Pseudomonas aeruginosa (ATCC 9027), Escherichia coli (ATCC 8939), E. coli H7 (O156), and ESBL E. coli. Bacteriostatic and bactericidal activities were determined using minimum bactericidal concentration/MIC ratio.Results: The ethanolic extract, n-hexane and ethyl acetate fractions of A. cordifolia from the first method had antibacterial activity against S. aureus, MRSA, B. subtilis, and B. cereus (MIC 256-512 μg/ml). However, n-hexane and ethyl acetate extract from the second method had broad spectrum of antibacterial activity, which could inhibit the growth of S. aureus, MRSA, B. subtilis, P. aeruginosa, and E. coli (MIC 256-512 μg/ml). Extracts and fractions showed bacteriostatic and bactericidal activities, but n-hexane extract has most bactericidal activity. Furthermore, steroid/triterpenoid, ursolic, and OA were found in this extract.Conclusion: The n-hexane extract from the second method showed the highest antibacterial activity.

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Cavedo, Enrica, Simone Lista, Marion Houot, Andrea Vergallo, Michel J. Grothe, Stefan Teipel, Henrik Zetterberg et al. "Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease". Neurology 94, n. 1 (4 dicembre 2019): e30-e41. http://dx.doi.org/10.1212/wnl.0000000000008696.

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ObjectiveTo investigate whether baseline concentrations of plasma total tau (t-tau) and neurofilament light (NfL) chain proteins are associated with annual percent change (APC) of the basal forebrain cholinergic system (BFCS) in cognitively intact older adults at risk for Alzheimer disease (AD).MethodsThis was a large-scale study of 276 cognitively intact older adults from the monocentric INSIGHT-preAD (Investigation of Alzheimer's Predictors in Subjective Memory Complainers) cohort. Participants underwent baseline assessment of plasma t-tau and NfL concentrations as well as baseline and 24-month follow-up MRI scans. Linear models with and without influential observations (calculated using the Cook distance) were carried out to investigate the effect of plasma NfL and t-tau concentrations, and their interaction effect with β-amyloid status and APOE genotype, on the APC of the whole BFCS and its anterior (Ch1/2) and posterior (Ch4) subdivisions separately.ResultsHigher plasma t-tau concentrations at baseline were associated with higher BFCS rate of atrophy (model without influencers: n = 251, F value = 4.6815; p value = 0.031). Subregional analyses showed similar results for both the APC of the Ch1/2 (model without influencers: n = 256, F value = 3.9535, p corrected = 0.047) and Ch4 BFCS sectors (model without influencers: n = 253, F value = 4.9090, p corrected = 0.047). Baseline NfL, β-amyloid load, and APOE ε4 carrier status did not affect APC of the BFCS.ConclusionIncreased concentrations of baseline plasma t-tau may predict in vivo structural BFCS atrophy progression in older adults at risk for AD, independently of β-amyloid status and APOE genotype.

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Guimarães, Fernando, Alessandra Soares Schanoski, Tereza Cristina Samico Cavalcanti, Priscila Bianchi Juliano, Ana Neuza Viera-Matos e Ovídio Rettori. "Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor". Brazilian Archives of Biology and Technology 53, n. 5 (ottobre 2010): 1101–8. http://dx.doi.org/10.1590/s1516-89132010000500014.

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The present study aimed at characterizing the subcutaneous development of the Walker 256 (W256) AR tumor, a regressive variant of the rat W256 A tumor. Wistar rats were injected subcutaneously with 4x10(6) W256 A or W256 AR tumor cells. The development of tumors was evaluated daily by percutaneous measurements. None of the W256 A tumors (n=20) regressed, but 62% of the W256 AR tumor-bearing rats (n=21) underwent complete tumor regression within 35 days. Continuous growth of AR tumors was characterized by an increase of the tumor growth rate from day 12, which reached values above 1.0 g/day, and were significantly higher (p<0.05) than those of the regressive AR tumors. Immunosuppression by irradiation before subcutaneous injection of AR cells completely abrogated tumor regression and was associated with severe metastatic dissemination. Daily evaluation of the tumor growth rate enabled the discrimination, in advance, between continuously growing tumors and those that regressed later on.

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Warren, Richard H. "Factoring on a quantum annealing computer". Quantum Information and Computation 19, n. 3&4 (marzo 2019): 252–61. http://dx.doi.org/10.26421/qic19.3-4-5.

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This paper is about quantum factoring all integers in an interval. Our goal is to be able to factor all positive integers N < 1,000. We reached this goal on a D-Wave 2000 qubit processor by minimizing (N - (pxq))^2 by using one routine that calls the interface software dw. We sized p<32 and q<256 as Boolean variables. We factored seven semiprimes that could not be factored by the method in a 2016 D-Wave report. We did not use information about the factors for a specific N. The inputs to our routine are N and values for two parameters.

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Aldridge, Patrick, Sarah Wilson, Damian Roland, Gerard McCann e Richard George Burridge. "Impact of COVID-19 on paediatric emergency department attendances at four English hospitals". BMJ Paediatrics Open 6, n. 1 (febbraio 2022): e001345. http://dx.doi.org/10.1136/bmjpo-2021-001345.

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Paediatric emergency department (PED) attendances reduced worldwide during the COVID-19 pandemic (2020) but anecdotally babies under 30 days (BUD) appeared less affected. We collated monthly PED attendances (16 years and under) across four hospitals (three district general hospitals and a tertiary specialist PED) in England, UK from January 2017 to December 2020. Gross PED attendances dropped by 34% in 2020 (n=98 256) compared to 2019 (n=148 640). However, cumulative BUD attendances dropped by only 6% in 2020 (n=3922) compared to 2019 (n=4162). Monthly site-specific attendances showed marginal variation. PED attendances broadly decreased in 2020 with less of an impact on BUD.

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Abreu-Pereira, César Augusto, Ana Luiza Gorayb-Pereira, João Vinícius Menezes Noveletto, Cláudia Carolina Jordão e Ana Cláudia Pavarina. "Zerumbone Disturbs the Extracellular Matrix of Fluconazole-Resistant Candida albicans Biofilms". Journal of Fungi 9, n. 5 (16 maggio 2023): 576. http://dx.doi.org/10.3390/jof9050576.

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This study assessed the effect of zerumbone (ZER) against fluconazole-resistant (CaR) and -susceptible Candida albicans (CaS) biofilms and verified the influence of ZER on extracellular matrix components. Initially, to determine the treatment conditions, the minimum inhibitory concentration (MIC), the minimum fungicidal concentration (MFC) and the survival curve were evaluated. Biofilms were formed for 48 h and exposed to ZER at concentrations of 128 and 256 µg/mL for 5, 10 and 20 min (n = 12). One group of biofilms did not receive the treatment in order to monitor the effects. The biofilms were evaluated to determine the microbial population (CFU/mL), and the extracellular matrix components (water-soluble polysaccharides (WSP), alkali-soluble polysaccharides (ASPs), proteins and extracellular DNA (eDNA), as well as the biomass (total and insoluble) were quantified. The MIC value of ZER for CaS was 256 μg/mL, and for CaR, it was 64 μg/mL. The survival curve and the MFC value coincided for CaS (256 μg/mL) and CaR (128 μg/mL). ZER reduced the cellular viability by 38.51% for CaS and by 36.99% for CaR. ZER at 256 µg/mL also reduced the total biomass (57%), insoluble biomass (45%), WSP (65%), proteins (18%) and eDNA (78%) of CaS biofilms. In addition, a reduction in insoluble biomass (13%), proteins (18%), WSP (65%), ASP (10%) and eDNA (23%) was also observed in the CaR biofilms. ZER was effective against fluconazole-resistant and -susceptible C. albicans biofilms and disturbed the extracellular matrix.

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Osadchuk, O. V., V. V. Martyniuk, T. I. Sydoruk e O. O. Semenova. "Physical Parameters of the Synthesized Complex Compound of Cobalt (II) with N, N'-Bis(salicylidene)semicarbazide". Physics and Chemistry of Solid State 21, n. 4 (31 dicembre 2020): 749–55. http://dx.doi.org/10.15330/pcss.21.4.749-755.

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A new material of strontium tetraaquad[N, N'-bis(salicylidene)semicarbazidatocobalt(II)] dihydrate (I) with the following composition: Sr[CoL'(Н2О)2]22Н2О, where H3L = N,N'-bis(salicylidene)semicarbazide was synthesized. The molar mass of the extracted and dehydrated complex compound Sr[Co (C15H14N3O5)]2 is 838.07 g/mol, and the number of valence electrons in one molecule is 256. A cylindrical sample with a mass of 0.09 g and a volume of 17.67∙10-9 m3 was utilized for experimental studies. Experimental measurements and theoretical calculations for the main physical parameters of the synthesized material were performed. Such quantities were calculated: the substance density, the molecule mass, the number of molecules in the test cylindrical sample, the number of valence electrons, the bandgap. Dependences of specific conductivity, current density, resistance, the Hall coefficient, and charge carrier concentration on temperature were obtained.

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Huys, Geert, Klaas D'Haene, Jean-Marc Collard e Jean Swings. "Prevalence and Molecular Characterization of Tetracycline Resistance in Enterococcus Isolates from Food". Applied and Environmental Microbiology 70, n. 3 (marzo 2004): 1555–62. http://dx.doi.org/10.1128/aem.70.3.1555-1562.2004.

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ABSTRACT In the present study, a collection of 187 Enterococcus food isolates mainly originating from European cheeses were studied for the phenotypic and genotypic assessment of tetracycline (TC) resistance. A total of 45 isolates (24%) encompassing the species Enterococcus faecalis (n = 33), E. durans (n = 7), E. faecium (n = 3), E. casseliflavus (n = 1), and E. gallinarum (n = 1) displayed phenotypic resistance to TC with MIC ranges of 16 to 256 μg/ml. Eight of these strains exhibited multiresistance to TC, erythromycin, and chloramphenicol. By PCR detection, TC resistance could be linked to the presence of the tet(M) (n = 43), tet(L) (n = 16), and tet(S) (n = 1) genes. In 15 isolates, including all of those for which the MIC was 256 μg/ml, both tet(M) and tet(L) were found. Furthermore, all tet(M)-containing enterococci also harbored a member of the Tn916-Tn1545 conjugative transposon family, of which 12 erythromycin-resistant isolates also contained the erm(B) gene. Filter mating experiments revealed that 10 E. faecalis isolates, 3 E. durans isolates, and 1 E. faecium isolate could transfer either tet(M), tet(L), or both of these genes to E. faecalis recipient strain JH2-2. In most cases in which only tet(M) was transferred, no detectable plasmids were acquired by JH2-2 but instead all transconjugants contained a member of the Tn916-Tn1545 family. Sequencing analysis of PCR amplicons and evolutionary modeling showed that a subset of the transferable tet(M) genes belonged to four sequence homology groups (SHGs) showing an internal homology of ≥99.6%. Two of these SHGs contained tet(M) mosaic structures previously found in Tn916 elements and on Lactobacillus and Neisseria plasmids, respectively, whereas the other two SHGs probably represent new phylogenetic lineages of this gene.

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Souza, Leonardo Cruz de, Sonia Maria Dozzi Brucki, Lucas Porcello Schilling, Letícia Costa da Silva, Leonel Tadao Takada, Valéria Santoro Bahia, Breno José Alencar Pires Barbosa et al. "Current clinical and research practices on frontotemporal dementia in Brazil: a national survey". Arquivos de Neuro-Psiquiatria 81, n. 07 (luglio 2023): 632–40. http://dx.doi.org/10.1055/s-0043-1771173.

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Abstract Background Frontotemporal dementia (FTD) is a frequent cause of young-onset dementia and represents a major challenge for the diagnosis and clinical management. It is essential to evaluate the difficulties faced by physicians on the diagnostic workup and on patient care. Objective The aim of this study was to investigate the current practices and the local limits on the diagnosis and management of FTD in Brazil. Methods We elaborated an online survey, composed of 29 questions and divided in four parts, comprising questions about existing health facilities, clinical practices related to FTD, and suggestions to increment the national research on FTD. The invitation to participate was sent by email to all neurologists affiliated to the Brazilian Academy of Neurology (n = 3658), and to all physicians who attended the XII Meeting of Researchers on Alzheimer's disease, in 2019 (n = 187). The invitation was also diffused through social media. Results 256 Brazilian physicians answered the questionnaire. The three most relevant disorders for the differential diagnosis of FTD were Alzheimer's disease (AD) (n = 211), bipolar disorder (n = 117) and dementia with Lewy bodies (n = 92). Most respondents (125/256) reported the difficulty in performing genetic testing as the main limit in the diagnostic of FTD. 93% and 63% of participants considered that the assessment of social cognition and AD CSF biomarkers are useful for the diagnosis of FTD, respectively. Conclusions The present study may provide valuable insights for the medical education and clinical training of physicians, and to foster future research on FTD in Brazil.

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Lindoff, Claes, Göran Rybo e Birger Åstedt. "Treatment with Tranexamic Acid during Pregnancy, and the Risk of Thrombo-Embolic Complications". Thrombosis and Haemostasis 70, n. 02 (1993): 238–40. http://dx.doi.org/10.1055/s-0038-1649475.

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SummaryTranexamic acid (AMCA) is an inhibitor of fibrinolysis used to treat fibrinolytic bleeding (e.g., menorrhagia and gastro-intestinal haemorrhage), and to prevent bleeding at surgery, in cases of abruptio placentae and general haemorrhage. As AMCA stabilises preformed clots and prolongs their dissolution, it has been debated whether treatment with AMCA might predispose to thrombosis by depressing the fibrinolytic system. Pregnant women constitute a group with low fibrinolytic capacity and an increased frequency of thrombosis further increased after Caesarean section, and are thus more likely to be susceptible to antifibrinolytic therapy. We therefore carried out a retrospective analysis of the case records of 2,102 patients with various bleeding disorders during pregnancy. Of the 256 patients treated with AMCA (mean duration of treatment, 46 days), 169 were delivered by Caesarean section. Of the remaining 1,846 patients (i.e., controls), 443 were delivered by Caesarean section. The relationship between the use of AMCA and the occurrence of thrombo-embolism was calculated with 95% confidence limits.Of the AMCA treated group (n = 256), two patients – one of whom belonged to the Caesarean section subgroup (n = 168) – had pulmonary embolism. Of the controls (n = 1,846), three patients had deep vein thrombosis and one had pulmonary embolism, all four cases belonging to the Caesarean section subgroup (n = 443). Thus, the findings in this high risk group of women with complicated pregnancies, frequently entailing delivery by Caesarean section, provided no evidence of any thrombogenic effect of AMCA.

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Amitava, Nag, Arup Kumar Chattopadhyay e Maitra Paramita. "An Efficient (t,n) Threshold Secret Image Sharing Scheme Based on Thien-Lin Secret Image Sharing". American Journal of Advanced Computing 1, n. 4 (1 ottobre 2020): 1–4. http://dx.doi.org/10.15864/ajac.1401.

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In a (t, n) threshold secret image sharing scheme (TSIS), a secret image is first encoded into n pieces, normally referred as shares or shadow images. Those share-images can be stored or transferred safely as individually a share-image cannot reveal any detail about the secret image. The receiver or user of the share-images referred as participants. If at least t(≤n) share-images are submitted by the participants, the secret image can be recomputed. One of the most popular secret image sharing schemes was proposed by Thien-Lin (2002). The authors had proposed two versions of the scheme. The first version of SIS by Thien-Lin is efficient, but lossy as the pixel values more than 250 (< 256) are truncated to 250. The second one is lossless, but it increases the size of the secret image during preprocessing. In this paper, we propose a secret image sharing scheme based on Thien-Lin scheme. We consider a little loss in the reconstructed image which is maximum one per pixel (the loss can be one to five in Thien-Lin scheme) and keep the size of the secret image same. Although buffer pixels may be added for the sake of programming, after reconstruction of the secret image the buffer pixels are easily identifiable and can be safely removed.

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Mohsin, Zehra, Sarah Shahed e Talat Sohail. "Correlates of Professional Quality of Life in Nurses". Annals of King Edward Medical University 23, n. 4 (2 marzo 2018): 463–67. http://dx.doi.org/10.21649/akemu.v23i4.2222.

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To look into the correlation between demographic variables, perceived social support and professional quality of lifeof nurses in public hospitals. A sample of 160 nurses of age (M=33.48, SD=9.18) was selected from public hospitals of Lahore. The nurses completed a demographic information form, MultidimensionalScale of Perceived Social Supportand Professional Quality of Life Scale. The data were analyzed using SPSS version 20. Two demographic variables, age and experience had significant positive correlation with compassion fatigue, r =.252, n=160, p <.01 and r =.256, n=160, p <.01 respectively. Other demographicvariables i.e. working hours and monthly income had no significant relationship with the subscales of Professional Quality of Life (compassion satisfaction, compassion fatigue and burnout). Perceived Social Support had a significant correlation with compassion satisfaction, r=.222, n=160, p<.01. It was concluded that the relationship between age, experience and compassion fatigue of nurses was significantly positive. The greater the age and experience of the nurses the more likely they are to have compassion fatigue. Perceived Social Support was related with compassion satisfaction which suggests that nurses’ perception of social support can increase their compassion satisfaction.

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Nash, Martyn P., Judith M. Thornton, Claire E. Sears, Anthony Varghese, Mark O'Neill e David J. Paterson. "Ventricular activation during sympathetic imbalance and its computational reconstruction". Journal of Applied Physiology 90, n. 1 (1 gennaio 2001): 287–98. http://dx.doi.org/10.1152/jappl.2001.90.1.287.

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We characterized the epicardial activation sequence during a norepinephrine (NE)-induced ventricular arrhythmia in anesthetized pigs and studied factors that modulated it. Subepicardial NE infusion caused the QRS complex to invert within a single beat ( n = 35 animals, 101 observations), and the earliest epicardial activation consistently shifted to the randomly located infusion site ( n = 14). This preceded right atrial activation, whereas the total ventricular epicardial activation time increased from 20 ± 4 to 50 ± 9 ms ( P < 0.01). These events were accompanied by a ventricular tachycardia and a drop in left ventricular pressure, which were fully reversed after the infusion was stopped. Epicardial pacing at the infusion site mimicked all electrical and hemodynamic changes induced by NE. The arrhythmia was prevented by propranolol and abolished by cardiac sympathetic or vagal nerve stimulation. Focal automaticity was computationally reconstructed using a two-dimensional sheet of 256 × 256 resistively coupled ventricular cells, where calcium handling was abnormally high in the central region. We conclude that adrenergic stimulation to a small region of the ventricle elicits triggered automaticity and that computational reconstruction implicates calcium overload. Interventions that reduce spatial inhomogeneities of intracellular calcium may prevent this type of arrhythmia.

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Petyunina, Olga, Mykola Kopytsya e Olga Skrynnyk. "The role of single nucleotide polymorphism Val66Met in BDNF gene in the formation of end points after ST segment elevation myocardial infarction". Ukrains'kyi Visnyk Psykhonevrolohii 27, n. 3 (5 settembre 2019): 19–25. http://dx.doi.org/10.36927/2079-0325-v27-is3-2019-3.

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The purpose of this study was to research the possible associations of single-nucleotide polymorphism of Val66Met BDNF gene with the occurrence of endpoints after 6 months of follow-up after a myocardial infarction with ST elevation segment — ST segment elevation myocardial infarction (STEMI). To participate in the study, 256 patients which met all the inclusion criteria were hospitalized in the department of intensive care, State Institution “L. T. Malaya Therapy National Institute NAMSU” from January 2016 to February 2019. Blood fl ow to all patients was restored at the level TIMI III. The frequency of genotypes Val66Met gene for BDNF in STEMI patients (n = 256) was the following: 66ValVal — 74.2 % (n = 190), 66ValMet + 66MetMet — 25.8 % (n = 66). The study of single-nucleotide polymorphism of Val66Met gene BDNF (rs6265) was performed by real-time polymerase chain reaction using the “TacMan TMSNP Genotyping Assays” production of Thermo Fisher Scientifi c Assay IDC_11592758_1. The emotional state of the patients and its relationship with stress were assessed with the questionnaire “Depression, Anxiety and Stress Scale-21”. It turned out that the 66ValMet + 66MetMet polymorphism of the BDNF gene, stress and anxiety 10—14 days before the event, as well as reduced left ventricular ejection fraction, are associated with an unfavorable prognosis of the combined end point 6 months after STEMI and are its independent predictors.

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Corn, B. W., J. W. Goldwein, I. Evans e G. J. D'Angio. "Outcomes in low-risk babies treated with half-dose chemotherapy according to the Third National Wilms' Tumor Study." Journal of Clinical Oncology 10, n. 8 (agosto 1992): 1305–9. http://dx.doi.org/10.1200/jco.1992.10.8.1305.

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PURPOSE To determine whether the 50% dose reduction of all chemotherapeutic agents recommended for babies (less than or equal to 12 months of age) by the Third National Wilms' Tumor Study (NWTS-3) produced acceptable toxicity without sacrificing any survival benefit. MATERIALS AND METHODS The 365 babies enrolled in NWTS-3 had tumors of varying histologies and stages. The present analysis was restricted to the 256 infants who had tumors of favorable histology, were free of metastasis at diagnosis, and received treatment according to NWTS-3 guidelines. RESULTS Despite the recommended attenuation of drug doses observed in 75% of the chemotherapy courses received, outcomes for these babies were comparable to those obtained in older children given full doses of chemotherapy. Four-year survival rates for 256 babies with stages I (n = 199), II (n = 38), and III (n = 19) favorable-histology tumors were 96%, 95%, and 90%, respectively. The figures for 498 stage I, 342 stage II, and 373 stage III older children with favorable-histology lesions were 92%, 94%, and 91% in that order. There were no deaths from hematologic toxicity or infection among babies who received half-dose chemotherapy. The death rates for their older NWTS-3 counterparts was 1%. CONCLUSION Less aggressive therapies advocated for babies in NWTS-3 provide acceptable levels of morbidity without compromising the excellent results previously reported for low-risk patients of all ages.

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