Bibliografie tematiche / MSPR

Letteratura scientifica selezionata sul tema "MSPR"

Autore: Grafiati

Pubblicato: 8 giugno 2024

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Articoli di riviste sul tema "MSPR":

Kadekoppala, Madhusudan, Rebecca A. O'Donnell, Munira Grainger, Brendan S. Crabb e Anthony A. Holder. "Deletion of the Plasmodium falciparum Merozoite Surface Protein 7 Gene Impairs Parasite Invasion of Erythrocytes". Eukaryotic Cell 7, n. 12 (26 settembre 2008): 2123–32. http://dx.doi.org/10.1128/ec.00274-08.

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ABSTRACT Merozoite surface proteins have been implicated in the initial attachment to the host red blood cell membrane that begins the process of invasion, an important step in the life cycle of the malaria parasite. In Plasmodium falciparum, merozoite surface proteins include several glycosylphosphatidyl inositol-anchored proteins and peripheral proteins attached to the membrane through protein-protein interactions. The most abundant of these proteins is the merozoite surface protein 1 (MSP1) complex, encoded by at least three genes: msp1, msp6, and msp7. The msp7 gene is part of a six-member multigene family in Plasmodium falciparum. We have disrupted msp7 in the Plasmodium falciparum D10 parasite, as confirmed by Southern hybridization. Immunoblot and indirect immunofluorescence analyses confirmed the MSP7 null phenotype of D10ΔMSP7 parasites. The synthesis, distribution, and processing of MSP1 were not affected in this parasite line. The level of expression and cellular distribution of the proteins MSP1, MSP3, MSP6, MSP9, and SERA5 remained comparable to those for the parental line. Furthermore, no significant change in the expression of MSP7-related proteins, except for that of MSRP5, was detected at the transcriptional level. The lack of MSP7 was not lethal at the asexual blood stage, but it did impair invasion of erythrocytes by merozoites to a significant degree. Despite this reduction in efficiency, D10ΔMSP7 parasites did not show any obvious preference for alternate pathways of invasion.

Pearce, J. Andrew, Tony Triglia, Anthony N. Hodder, David C. Jackson, Alan F. Cowman e Robin F. Anders. "Plasmodium falciparum Merozoite Surface Protein 6 Is a Dimorphic Antigen". Infection and Immunity 72, n. 4 (aprile 2004): 2321–28. http://dx.doi.org/10.1128/iai.72.4.2321-2328.2004.

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ABSTRACT Merozoite surface protein 1 (MSP1) is a highly polymorphic Plasmodium falciparum merozoite surface protein implicated in the invasion of human erythrocytes during the asexual cycle. It forms a complex with MSP6 and MSP7 on the merozoite surface, and this complex is released from the parasite around the time of erythrocyte invasion. MSP1 and many other merozoite surface proteins contain dimorphic elements in their protein structures, and here we show that MSP6 is also dimorphic. The sequences of eight MSP6 genes indicate that the alleles of each dimorphic form of MSP6 are highly conserved. The smaller 3D7-type MSP6 alleles are detected in parasites from all malarious regions of the world, whereas K1-type MSP6 alleles have only been detected in parasites from mainland Southeast Asia. Cleavage of MSP6, which produces the p36 fragment in 3D7-type MSP6 and associates with MSP1, also occurs in K1-type MSP6 but at a different site in the protein. Anti-3D7 MSP6 antibodies weakly inhibited erythrocyte invasion by homologous 3D7 merozoites but did not inhibit a parasite line expressing the K1-type MSP6 allele. Antibodies from hyperimmune individuals affinity purified on an MSP3 peptide cross-reacted with MSP6; therefore, MSP6 may also be a target of antibody-dependent cellular inhibition.

Boyle, Michelle J., Christine Langer, Jo-Anne Chan, Anthony N. Hodder, Ross L. Coppel, Robin F. Anders e James G. Beeson. "Sequential Processing of Merozoite Surface Proteins during and after Erythrocyte Invasion by Plasmodium falciparum". Infection and Immunity 82, n. 3 (11 novembre 2013): 924–36. http://dx.doi.org/10.1128/iai.00866-13.

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ABSTRACTPlasmodium falciparumcauses malaria disease during the asexual blood stages of infection when merozoites invade erythrocytes and replicate. Merozoite surface proteins (MSPs) are proposed to play a role in the initial binding of merozoites to erythrocytes, but precise roles remain undefined. Based on electron microscopy studies of invadingPlasmodiummerozoites, it is proposed that the majority of MSPs are cleaved and shed from the surface during invasion, perhaps to release receptor-ligand interactions. In this study, we demonstrate that there is not universal cleavage of MSPs during invasion. Instead, there is sequential and coordinated cleavage and shedding of proteins, indicating a diversity of roles for surface proteins during and after invasion. While MSP1 and peripheral surface proteins such as MSP3, MSP7, serine repeat antigen 4 (SERA4), and SERA5 are cleaved and shed at the tight junction between the invading merozoite and erythrocyte, the glycosylphosphatidylinositol (GPI)-anchored proteins MSP2 and MSP4 are carried into the erythrocyte without detectable processing. Following invasion, MSP2 rapidly degrades within 10 min, whereas MSP4 is maintained for hours. This suggests that while some proteins that are shed upon invasion may have roles in initial contact steps, others function during invasion and are then rapidly degraded, whereas others are internalized for roles during intraerythrocytic development. Interestingly, anti-MSP2 antibodies did not inhibit invasion and instead were carried into erythrocytes and maintained for approximately 20 h without inhibiting parasite development. These findings provide new insights into the mechanisms of invasion and knowledge to advance the development of new drugs and vaccines against malaria.

Sayapin, S. N. "Mobile speleological parallel robot with a spatial tactile system for identification of the contact surface". Proceedings of Higher Educational Institutions. Маchine Building, n. 12 (753) (dicembre 2022): 46–58. http://dx.doi.org/10.18698/0536-1044-2022-12-46-58.

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The paper considers the problem of conducting speleological studies of natural and artificial caves, including channels of the underground rivers, as well as various mine workings in dangerous or inaccessible conditions for a speleologist. In this case, external environment of the objects under study could turn out to be opaque for optical, radio, ultrasonic and other physical methods of monitoring the inner surface, for example, due to partial or complete flooding of the object with water with inhomogeneous suspensions. A solution to the problem is proposed by robotizing the research using a mobile speleological parallel robot (MSPR) with a spatial tactile system for identification of the contact surface. MSPR is created in the form of an active octahedral structure, which edges are rods with linear drives. The rod ends are pivotally connected to the corresponding vertices of the active octahedral structure ensuring its geometric invariability when the linear drives are turned off. As a result, MSPR is able to carry out contact (tactile) mapping of the inner surface under study regardless of the external environment transparency and its geodetic binding to the base coordinate system with visualization in the form of histograms. At the same time, MSPR is able to self-move along the internal surfaces regardless of their spatial orientation. MSPR and its functionalities are described, one of which is the ability to build the 3D histograms of the surrounding space bind to the base (inertial) coordinate system through the mechanical contact. The tactile system of identifying the contact surface makes it possible not only to move the MSPR, but also to tactilely monitor in the external environment that is opaque for optical, radio, ultrasonic and other physical control methods. MSPR allows robotizing speleological research in dangerous, hard-to-reach and inaccessible places for a speleologist, as well as to carry out rescue operations and ensure delivery of the required cargo.

Yu, Jinjin, Fenghao Zhang, Zhi Chen e Liman Liu. "MSPR-Net: A Multi-Scale Features Based Point Cloud Registration Network". Remote Sensing 14, n. 19 (29 settembre 2022): 4874. http://dx.doi.org/10.3390/rs14194874.

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Point-cloud registration is a fundamental task in computer vision. However, most point clouds are partially overlapping, corrupted by noise and comprised of indistinguishable surfaces, especially for complexly distributed outdoor LiDAR point clouds, which makes registration challenging. In this paper, we propose a multi-scale features-based point cloud registration network named MSPR-Net for large-scale outdoor LiDAR point cloud registration. The main motivation of the proposed MSPR-Net is that the features of two keypoints from a true correspondence must match in different scales. From this point of view, we first utilize a multi-scale backbone to extract the multi-scale features of the keypoints. Next, we propose a bilateral outlier removal strategy to remove the potential outliers in the keypoints based on the multi-scale features. Finally, a coarse-to-fine registration way is applied to exploit the information both in feature and spatial space. Extensive experiments conducted on two large-scale outdoor LiDAR point cloud datasets demonstrate that MSPR-Net achieves state-of-the-art performance.

Bokalo, Miko, Stephen J. Titus e Douglas P. Wiens. "Sampling with Partial Replacement Extended To Include Growth Projections". Forest Science 42, n. 3 (1 agosto 1996): 328–34. http://dx.doi.org/10.1093/forestscience/42.3.328.

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Abstract The original theory of Sampling with Partial Replacement (SPR) is modified to incorporate growth model projections of the unmatched plot data on the initial measurement. The Modified Sampling with Partial Replacement (MSPR) theory is illustrated by estimating growth and current volume using simulated plot data. In addition to the assumptions required by SPR, MSPR requires that the growth projection errors be random and have a mean of zero. If these assumptions are met, the modified theory improves the precision of the volume and growth estimators over the original SPR estimator. For. Sci. 42(3):328-334.

Domine, Daniel, James Devillers, Maurice Chastrette e Walter Karcher. "Multivariate structure-property relationships (MSPR) of pesticides". Pesticide Science 35, n. 1 (1992): 73–82. http://dx.doi.org/10.1002/ps.2780350110.

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She, Yue Hui, Fu Chang Shu, Zheng Liang Wang e Long Jiang Yu. "Investigation of Indigenous Microbial Enhanced Oil Recovery in a Middle Salinity Petroleum Reservoir". Advanced Materials Research 365 (ottobre 2011): 326–31. http://dx.doi.org/10.4028/www.scientific.net/amr.365.326.

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Culture-based techniques were applied to analyze the diversity of indigenous microbial communities in the Qinghai middle salinity petroleum reservoir (QH-MSPR). The results of the most probable number (MPN) method indicated there was an abundance of indigenous microbes (105-106MPN/ml). Two isolations (BIOS682) from the QH-MSPR were identified as Brevibacillus agri and Brevibacillus levickii. The study showed that BIOS682 enhanced the degradation rate of Huatugou crude oil. The viscosity and freezing point of crude oil after treatment by BIOS682 were all decreased. The results of TLC and FTIR spectrum analysis of the biosurfactant produced by BIOS682 indicated that it was identical to that of lipopeptide. The core-flooding tests showed that the incremental oil recoveries were 7.05-10.15%. Thus, BIOS682 may provide a viable application of microbial enhanced oil recovery (MEOR).

Dahl, John L., Farah K. Tengra, David Dutton, Jinyuan Yan, Tracy M. Andacht, Lia Coyne, Veronica Windell e Anthony G. Garza. "Identification of Major Sporulation Proteins of Myxococcus xanthus Using a Proteomic Approach". Journal of Bacteriology 189, n. 8 (9 febbraio 2007): 3187–97. http://dx.doi.org/10.1128/jb.01846-06.

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ABSTRACT Myxococcus xanthus is a soil-dwelling, gram-negative bacterium that during nutrient deprivation is capable of undergoing morphogenesis from a vegetative rod to a spherical, stress-resistant spore inside a domed-shaped, multicellular fruiting body. To identify proteins required for building stress-resistant M. xanthus spores, we compared the proteome of liquid-grown vegetative cells with the proteome of mature fruiting body spores. Two proteins, protein S and protein S1, were differentially expressed in spores, as has been reported previously. In addition, we identified three previously uncharacterized proteins that are differentially expressed in spores and that exhibit no homology to known proteins. The genes encoding these three novel major spore proteins (mspA, mspB, and mspC) were inactivated by insertion mutagenesis, and the development of the resulting mutant strains was characterized. All three mutants were capable of aggregating, but for two of the strains the resulting fruiting bodies remained flattened mounds of cells. The most pronounced structural defect of spores produced by all three mutants was an altered cortex layer. We found that mspA and mspB mutant spores were more sensitive specifically to heat and sodium dodecyl sulfate than wild-type spores, while mspC mutant spores were more sensitive to all stress treatments examined. Hence, the products of mspA, mspB, and mspC play significant roles in morphogenesis of M. xanthus spores and in the ability of spores to survive environmental stress.

Tewari, Rita, Solabomi A. Ogun, Ruwani S. Gunaratne, Andrea Crisanti e Anthony A. Holder. "Disruption of Plasmodium berghei merozoite surface protein 7 gene modulates parasite growth in vivo". Blood 105, n. 1 (1 gennaio 2005): 394–96. http://dx.doi.org/10.1182/blood-2004-06-2106.

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Abstract Merozoite invasion of red blood cells is crucial to the development of the parasite that causes malaria. Merozoite surface proteins (MSPs) mediate the first interaction between parasite and erythrocyte. In Plasmodium falciparum, they include a complex of products from at least 3 genes (msp1, msp6, and msp7), one of which, msp7, is part of a gene family containing 3 and 6 adjacent members in Plasmodium yoelii and Plasmodium falciparum, respectively. We have identified and disrupted msp7 in the Plasmodium berghei gene family. The protein is expressed in schizonts and colocalizes with MSP1. The synthesis and processing of MSP1 was unaffected in the parasite with the disrupted gene (MSP7ko). Disruption of msp7 was not lethal but affected blood-stage parasite growth. MSP7ko parasites initially grew more slowly than wild-type parasites. However, when reticulocytes were prevalent, the rate of increase in parasitemia was similar, suggesting that MSP7ko parasites prefer to invade and grow within reticulocytes. (Blood. 2005;105:394-396)

Più fonti

Tesi sul tema "MSPR":

Zhao, Yanqing. "Contributions à la détection précoce de chatter et à l’identification des bifurcations de période-N basée sur une approche de diagnostic cumulatif". Electronic Thesis or Diss., Université de Lorraine, 2020. http://www.theses.fr/2020LORR0250.

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Le diagnostic cumulatif des systèmes dynamiques nécessite la détection, l’identification et la caractérisation des dégradations naissantes. Son application à l'usinage à grande vitesse, par exemple, pourrait s’appuyer sur l’analyse des phénomènes de bifurcations de période-N pour détecter et identifier les chatters (broutages) naissants et améliorer la qualité des produits et des processus de fraisage. Jusqu'à présent, de nombrecuses méthodes efficaces ont été proposées pour détecter les broutages naissants et identifier les bifurcations de période-N. Cependant, ces méthodes peinent à mettre en œuvre ces tâches de manière fiable et précise. Le but de la présente thèse est de développer et mettre en œuvre des méthodes de détection de broutages naissants et d’identification de bifurcations de période-N dans une approche de diagnostic cumulatif temps réel. Afin de détecter les défauts de broutages naissants (early-chatter), nous avons proposé trois méthodes de détection et une méthode d’identification pour le diagnostic cumulatif. La première méthode peut être utilisée pour détecter à distance les broutages naissants. La deuxième méthode détecte rapidement les broutages naissants dans des conditions spécifiques de fonctionnement et de mesure. Mais dans la pratique, les conditions de fonctionnement et de mesure sont complexes et variables. Pour s'adapter aux différentes conditions de fonctionnement et de mesure, nous avons proposé une troisième méthode et cette dernière détecte de manière fiable les broutages naissants. On note également que dans les processus de fraisage, les broutages peuvent naître avec une bifurcation de type période-N ou de type Hopf. La qualité d'usinage sous un processus de bifurcation de type période-N est moins critique que celle de type Hopf. Ainsi, il est indispensable d’identifier précocement les bifurcations de type période-N pour améliorer l'efficacité d'usinage. Pour cela, nous avons développé une méthode d’identification du type et de la taille des bifurcations de période-N. Nous avons également prouvé l'efficacité des méthodes proposées, en utilisant deux modèles de processus de fraisage de référence. De plus, les méthodes proposées peuvent être utilisées pour le diagnostic de défaut d'autres systèmes dynamiques, tels que les systèmes de conversion d'énergie par modulation de largeur d'impulsion ou systèmes de paliers ou d’engrenage
Cumulative diagnosis of dynamic systems requires the detection, identification, and characterization of incipient degradations. Its application to high-speed machining, for instance, could rely on period-N bifurcations phenomena analysis to detect and identify early-chatters and improve the quality of milling products and processes. Up to now, many efficient methods were proposed to detect early-chatter and identify period-N bifurcations. But these methods are struggling to implement these tasks reliably and accurately due to the complex nonlinear characteristics of their dynamic behaviors, the noise, and the variation of their operating conditions. The present thesis aims to develop and implement methods of early-chatter detection and period-N bifurcations identification within a real-time cumulative diagnosis approach. Aimed at early-chatter detection, we proposed three detection methods and one identification method for the cumulative diagnosis. The first method can be used to detect early-chatters remotely. The second one detects early-chatter quickly under specific operating and measuring conditions. However, in practice, the operating and measuring conditions are complex and variable. To adapt to different operating and measuring conditions, we proposed a third method, and the latter detects early-chatter reliably. It is also noted that in milling processes, the early-chatter can give rise to a bifurcation of period-N or Hopf type. The machining quality under the bifurcation process of the period-N type is less critical than that under the Hopf bifurcation type. To improve machining productivity and ensure the required machining quality, we can mill the workpiece under the condition of period-N bifurcations. Thus, it is compulsory to identify the early period-N bifurcations for improving machining productivity. For that purpose, we developed a method for identifying the type and size of the period-N bifurcations. We also proved the effectiveness of the proposed methods, using two benchmark milling process models. Besides, the proposed methods can be used for fault diagnosis of other dynamic systems, such as the pulse energy conversion systems or bearing or gearing systems

Cruau, Aurélie. "Étude, conception, réalisation et test d' une capacité variable MEMS RF pour le traitement de fréquences entre 0. 5 et 20 GHz". Paris 7, 2005. http://www.theses.fr/2005PA077014.

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Zitouni, Adel. "Modélisation et conception d'un capteur à courants de Foucault intelligent pour l'identification de canalisations enterrées". Reims, 2006. http://theses.univ-reims.fr/exl-doc/GED00000353.pdf.

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Dans cette thèse, nous présentons la modélisation et la réalisation d'un capteur à courants de Foucault basé sur le principe de la balance d'induction. L'objectif de ce détecteur est la localisation et l'identification de canalisations enterrées sans fouille. Nous avons défini un code pour chaque type de canalisation, et la reconnaissance du code entraîne l'identification de la canalisation. Nous appelons code une succession de motifs conducteurs, la longueur et les espaces entre ces motifs varient d'un code à un autre. Notre détecteur comprend une bobine d'émission qui génère un champ électromagnétique, et des bobines réceptrices captant le champ réfléchi créé par les courants de Foucault induits dans les motifs conducteurs du code. Une mesure du déphasage par détection synchrone permet l'obtention d'un signal représentatif des motifs du code. Cette mesure est ensuite conditionnée grâce à une étape de filtrage et débruitage par séparation de sources afin d'éliminer la présence d'un éventuel objet conducteur aux alentours. L'analyse de données permet le calcul des paramètres pertinents pour effectuer la classification. Nous avons ajouté un nouveau système de codage compatible et complémentaire à l'ancien, ainsi que des classifieurs assurant son identification tels que : la distance transformée, DTW (Dynamic Time Warping) et la reconnaissance structurelle. Nous avons également ajouté trois classifieurs pour le premier système de codage, basés sur les K plus proches voisins, la distance de Mahalanobis et les fonctions à base radiale RBF pour renforcer le système de reconnaissance. Une combinaison des résultats des différents classifieurs par une méthode de fusion de données permet d'obtenir une bonne fiabilité du système. Dans la dernière partie, nous présentons les nombreuses perspectives de développement dont la principale repose sur l'utilisation de cibles magnétiques comme motifs de code
In this thesis, we present the modeling of an eddy current sensor based on the induction balance principle. The objective of this detector is the localization and the identification of buried pipes without excavation. We have defines a tag for each pipe type, and the recognition of the tag involves the identification of the pipe. We call tag a succession of conductive elements, the length and spaces between these elements vary from a tag to another. Our detector includes an emitting coil which generates an electromagnetic field, and receiving coils collect the reflected field created by the eddy current in the conductive elements of the tag. A measurement of dephasing by lock-in detection allows obtaining a signal representative of the tag elements. This measurement is then conditioned thanks to a stage of filtering and denoising per Blind Source Separation (BSS) in order to eliminate the presence of an eventual conductive object in the neighbourhoods. The data analysis allows the calculation of the pertinent parameters to carry out classification. We added a new coding system compatible and complementary to the old one, as well as classifiers ensuring his identification such as: the transformation distance, DTW (Dynamic Time Warping) and the structural recognition. We added three classifiers for the first coding system, based on K near neighbourhood, the Mahalanobis distance and the Radial Basis Function (RBF) to reinforce the recognition system. A combination of the various classifiers results by a method of data fusion makes it possible to obtain a good reliability of the system. In the last part, we present the many development prospects whose principal one rests on the use of magnetic targets like tag elements

Lind, Anders. "High-speed View Matching using Region Descriptors". Thesis, Linköping University, Computer Vision, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-58843.

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This thesis treats topics within the area of object recognition. A real-time view matching method has been developed to compute the transformation between two different images of the same scene. This method uses a color based region detector called MSCR and affine transformations of these regions to create affine-invariant patches that are used as input to the SIFT algorithm. A parallel method to compute the SIFT descriptor has been created with relaxed constraints so that the descriptor size and the number of histogram bins can be adjusted. Additionally, a matching step to deduce correspondences and a parallel RANSAC method have been created to estimate the undergone transformation between these descriptors. To achieve real-time performance, the implementation has been targeted to use the parallel nature of the GPU with CUDA as the programming language. Focus has been put on the architecture of the GPU to find the best way to parallelize the different processing steps. CUDA has also been combined with OpenGL to be able to use the hardware accelerated anisotropic sampling method for affine transformations of regions. Parts of the implementation can also be used individually from either Matlab or by using the provided C++ library directly. The method was also evaluated in terms of accuracy and speed. It was shown that our algorithm has similar or better accuracy at finding correspondences than SIFT when the 3D geometry changes are large but we get a slightly worse result on images with flat surfaces.

Ekala, Borise Marie-Thérèse. "Étude des réponses humorales spécifiques des familles alléliques des antigènes de surface du mérozoite, MSP1 et MSP2, dans le paludisme à Plasmodium falciparum". Paris 6, 2002. http://www.theses.fr/2002PA066120.

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Kano, Flora Satiko. "Anaplasma marginale : análise da variabilidade do gene msp1 a e avaliação imunogênica da vacina de DNA contendo genes para MSP1a, MSP1b e MSP5 em camundongos BALB/c". Universidade Estadual de Londrina. Centro de Ciências Agrárias. Programa de Pós-Graduação em Ciência Animal, 2007. http://www.bibliotecadigital.uel.br/document/?code=vtls000123331.

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O Anaplasma marginale é um importante patógeno riquetsial de bovinos transmitido por carrapato que invade e se multiplica dentro de eritrócitos, causando anemia hemolítica durante a infecção aguda. A imunização com proteínas de membrana externa (OMP) purificadas induz proteção contra doença aguda. Das 21 OMPs descritas, seis MSPs (1a, 1b, 2-5) já foram bem caracterizadas. O complexo MSP1 (MSP1a e 1b) é adesinas de eritrócitos de bovinos. A MSP1a varia em tamanho pelo número de repetições in tandem de 28-29 aminoácidos. Vacina de DNA contra a anaplasmose tem sido investigada usando os genes msp1? e msp1?, e os resultados evidenciaram resposta celular e humoral em camundongos e bovinos. A imunização com DNA plasmidial que codifica genes de interesse é uma tecnologia nova e promissora no desenvolvimento de vacinas. Vacinas de DNA que visam múltiplos epitopos têm se mostrado mais eficientes aumentando a imunogenicidade e a proteção de animais vacinados quando comparadas com as de epitopo único. Os objetivos deste trabalho foram analisar a variabilidade do gene msp1a de amostras paranaenses de A. marginale, testar a capacidade dos plasmídios recombinantes expressarem MSP1a, MSP1b e MSP5 em células eucarióticas e avaliar a imunogenicidade destas vacinas administradas individualmente ou em associação, em camundongos BALB/c. A análise da região repetitiva do gene msp1a identificou a presença de seis, cinco e três repetições nas amostras PR1, PR2 e PR3, respectivamente, e seis padrões de repetições inéditas. Contudo, a região da MSP1a responsável pela imunogenicidade foi conservada. Os plasmídios pcDNA/ msp1a, pcDNA/ msp1 ? e pcDNA/ msp5, os quais codificam os genes das MSPs sob o controle do promotor do citomegalovirus e intron A, foram construídos, multiplicados em E. coli TOPO10 e purificados. A expressão das proteínas MSP1a, MSP1b e MSP5 in vitro foi realizada em células Vero usando lipofectamina 2000 e Imunofluorescência Indireta (IFA), utilizando anticorpos monoclonais. Sete grupos de camundongos foram imunizados para avaliar a produção de IgG total e determinar os isotipos IgG1 e IgG2a: G1-100 mL PBS; G2-100 mg de vetor; G3- 100 mg de corpúsculos iniciais de A. marginale + adjuvante de Freund; G4- 100 mg pcDNA-msp1a; G5-100 mg pcDNA-msp1b; G6-100 mg of pcDNA-msp5 e G7- pool de plasmídios (33 mg de cada plasmídio). Três semanas após a última imunização, os camundongos foram sacrificados para avaliar a proliferação dos esplenócitos. As células Vero transfectadas com plasmídios recombinantes reagiram com anticorpos monoclonais específicos, demonstrando a expressão dos genes msp. IgG específica para a MSP1a e MSP5 foram detectadas tanto por ELISA quanto por Western blot. Os grupos que receberam pcDNA-msp1a and pcDNA-msp5 mostraram predomínio do isotipo IgG2a, e proliferação de esplenócitos, sugerindo que estes plasmídios são bons candidatos para estimular reposta imune Th1. A associação dos três plasmídios recombinantes (pcDNA-msp1a, pcDNA-msp1b and pcDNA-msp5) empregados na imunização de camundongos induziram altos títulos de anticorpos por ELISA e reagiram com todas proteínas recombinantes (rMSP1a, rMSP1b e rMSP5) de A. marginale por Western blot. Adicionalmente, a combinação dos plasmídios levou a uma forte proliferação de linfócitos (SI = 12, 2), enquanto o gene msp1a determinou significante proliferação significativa (SI = 2,6) e os genes msp1b e msp5 não promoveram proliferação (SI<2). Os resultados demonstraram que a associação dos plasmídios induziu a expressão das MSPs e estimulou significante produção de linfócitos T, podendo ser uma estratégia eficiente para a imunoprofilaxia da anaplasmose.
Anaplasma marginale is an important tick-transmitted rickettsial pathogen of cattle that invades and multiplies within erythrocytes, causing severe hemolytic anemia during acute infection. Immunization with purified outer membrane proteins (OMP) induces protection against acute A. marginale disease. Of 21 OMP described six major surface proteins (MSPs 1a, 1b, 2-5) have been well-characterized. The complex MSP1 (MSP1a and 1b) is an adhesin for bovine erythrocyte, and MSP1a vary in size and sequence due to the number of tandem 28-29-amino acid repeats. DNA vaccine against anaplasmosis has been investigated using the msp1a and msp1? genes, and the results related cellular and humoral response in mice and cattle. Immunization with DNA plasmids encoding antigens of interest represents a novel and promising method in vaccine research and development. Multiepitope DNA vaccine is a new experience to increase immunogenicity and protection for vaccinated animal as compared in single epitope. The objectives of this study were to analyze the variability of the msp1a gene of A. marginale strains from Parana State, evaluate the capacity of the recombinant plasmids to express MSP1a, MSP1b, and MSP5 in eukaryotic cells, and evaluate the immunogenicity of BALB/c mice immunized with these DNA vaccines encoding MSPs of A. marginale PR1 strain individually or in association. The analysis of the msp1a gene identified the presence of six, five and three tandem repeats in PR1, PR2 PR3, respectively; however, the region of MSP1a responsible for immunogenicity was conserved. The plasmids pcDNA-msp1?, pcDNA-msp1? and pcDNA-msp5, which encode the MSPs genes under the control of cytomegalovirus enhancer/promoter and intron A, were constructed, multiplied in TOP10 E. coli and purified. Expression of MSP1a, MSP1b, and MSP5 in vitro was performed into Vero cells using lipofectamine 2000, following Indirect Immunofluorescen Assay (IFA) using monoclonal antibodies. Seven experimental groups of mice were immunized to evaluate the production of whole IgG and to determinate IgG1 and IgG2a isotype: G1-100 ml PBS; G2-100 mg empty vector; G3-100 mg A. marginale initial bodies + Freund´s adjuvant; G4-100 mg pcDNA-msp1a; G5-100 mg pcDNA-msp1b; G6-100 mg pcDNA-msp5; and G7-pool of recombinant plasmids (33 mg for each). Three weeks after the last immunization, mice were sacrified to evaluate spleen cells proliferation. Vero cells transfected with recombinants plasmids reacted with specific monoclonal antibodies, demonstrating the expression of msp genes. Specific IgG against MSP1a and MSP5 were detected in either by ELISA and Western blot. The groups that received pcDNA-msp1a and pcDNA-msp5 exhibited predominance for IgG2a production and splenocytes proliferation, suggesting that these recombinant plasmids are good candidates for elicited T helper 1 immune response. The association of three recombinant plasmids (pcDNA-msp1a, pcDNA-msp1b and pcDNA-msp5) used in the immunization of mice induced high antibodies response by ELISA and reacted with all recombinant proteins (rMSP1a, rMSP1b, and rMSP5) of A. marginale by Western blot. Also, the combination of plasmids provide strong lymphoproliferation (SI = 12,2), whereas the genes to MSP1a provide significant splenocytes (SI = 2,6) and the genes to MSP1b and MSP5 did not provide significant proliferation (SI<2). The results showed no suppression when the recombinant plasmids were taken in association, and demonstrated that they can generate significant T-cell lymphocyte. Thus, the immunization in association of recombinant plasmids encoding MSPs can be an effective strategy for immunoprofilaxy of anaplasmosis.

Mahler, Anna-Britt. "MULTIANGLE SPECTROPOLARIMETRIC IMAGER (MSPI)". Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/193923.

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Substantial impacts of aerosols on climate and public health underscore the need for accurate characterization of atmospheric aerosol distributions and microphysical properties. The Multiangle SpectroPolarimetric Imager (MSPI) combines accurate multispectral, multiangle, and polarimetric technologies in a single instrument that images a wide swath on the Earth's surface to advance aerosol remote sensing capabilities. MSPI is required to have 3% radiometric uncertainty and 0.005 degree of linear polarization (DoLP) uncertainty. These are difficult requirements that push the limits of available technologies needed to perform space-based polarimetric imaging. This work examines three topics related to MSPI fabrication and calibration: polarization errors and their correction, achromatic, athermal, quarter wave retarder fabrication, and analysis of a polarization state generator (PSG) for MSPI polarization calibration confirmation.MSPI polarization errors may arise from surface geometry of the optical components, coatings, and quarter wave plates (QWPs). Static polarization errors can be calibrated out, but result in decreased SNR. Polarization errors that drift following calibration cannot be corrected, so a sensitivity analysis is used to set time-varying diattenuation and retardance magnitude tolerances. QWPs are required to work in concert with the PEMs to modulate the linear component of the Stokes vector. A three-material achromatic, athermalized QWP was designed, fabricated and its performance validated. Analysis indicated that the compound QWP was unlikely to meet the requirements if plates were specified by thickness. To address this, a method for QWP fabrication was developed that involves monitoring retardance during polishing. To verify MSPI performance, a PSG was built and calibrated which outputs weakly linearly polarized light with DoLPs varying from 0.0005 to 0.4 with 0.0005 uncertainty by passing nearly unpolarized light through a tilted plane parallel plate. The PSG was intended to act as a calibration standard based on calculated DoLP, but proved difficult to model. Therefore, the DoLP was instead measured to repeatability of 0.0005. Finally, example spectropolarimetric image data taken with MSPI was presented. Work on a follow-on prototype continues that will advance the technologies needed to realize the space-based, fully capable MSPI.

Brovchenko, Mariya. "Études préliminaires de sûreté du réacteur à sels fondus MSFR". Phd thesis, Université de Grenoble, 2013. http://tel.archives-ouvertes.fr/tel-00956589.

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Les réacteurs nucléaires de 4ème génération devront permettre une utilisation optimisée desressources naturelles. Les travaux réalisés durant cette thèse se placent ainsi dans le cadre del'étude du potentiel de déploiement d'un tel réacteur : le MSFR (Molten Salt Fast Reactor), réacteurà sels fondus à spectre neutronique rapide dans une configuration innovante et encore peuétudiée. Comme un excellent niveau de sûreté est une condition nécessaire pour le déploiementde l'énergie nucléaire, il est important de soulever la question de la sûreté de ce type de réacteurdès les premières phases de sa conception.Le MSFR a fait l'objet d'études comparatives des outils de simulations numériques dans lecadre d'un benchmark neutronique au sein du projet européen EVOL. La définition et l'analysedu benchmark neutronique statique et en évolution ont été réalisées pendant cette thèse. Lescomparaisons des différentes grandeurs physiques ont permis de conclure à un bon accord entreles différents codes et méthodes utilisés par les partenaires du projet, et ont mis en avant l'influencedu choix des bases de données nucléaires. Dans l'objectif de l'étude de sûreté du MSFR,la puissance résiduelle a aussi été étudiée en détails. Un outil de calcul de chaleur résiduellea été développé et validé, permettant ainsi d'évaluer la puissance résiduelle précise du MSFR.Les sources de chaleur de chaque localisation contenant des produits radioactifs ont alors étéquantifiées. Ceci a permis de conclure que le sel combustible et l'unité de bullage constituent lessources majeures de puissance résiduelle.Nous avons initié un travail sur la méthodologie de l'étude de sûreté. Les principes fondamentauxde sûreté sont directement transposables au MSFR, mais leurs applications concrètes nele sont pas. En effet, la spécificité du design, due à l'état liquide du combustible et aux systèmesde retraitement associés au réacteur, ainsi que l'état embryonnaire du design, font qu'un travailpréliminaire de transposition des éléments de sûreté a dû être réalisé. Ce travail a conduit entreautres à dresser une liste d'accidents propres au MSFR. Enfin, nous avons pu mener des étudesphysiques préliminaires sur les conséquences possibles de certains de ces accidents, qui serontutilisées comme base pour des études plus approfondies avec des outils plus sophistiqués.

Hálková, Gabriela. "Bariéry internacionalizácie MSP". Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-16537.

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The thesis focuses on the barriers to the internationalization of SMEs. The theoretical part consists of four chapters outlining the basic theoretical resources necessary for the practical part. The first part explains the nature of internationalization and globalization, the second defines SMEs in the Czech Republic and the European Union, the third section presents the most important and most common barriers to the internationalization of SMEs, the last fourth part provides an overview of the institutions involved in export promotion in the Czech Republic. The practical part of the thesis consists of an analysis sample of four companies that led to the determination of the largest and most common barriers to the internationalization of Czech SMEs.

Celbová, Monika. "Podnikatelský plán MSP". Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-18155.

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The study presents a business plan for a firm which offers fishing services. The study consist of a theoretical part and a practical part. In the theoretical section the small and medium enterprises are specified, especially the family business and there are characteristics of the form, structure and terms of the business plan. The practical section focuses on elaboration of the business plan for the particular firm. It includes description of all activities, market analysis, financial plan, SWOT analysis, break-even point analysis and potential risks. As a result the study provides an examination of a feasibility of the business plan.

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Libri sul tema "MSPR":

Body, Scottish Parliamentary Corporate. SPCB/MSPs. [S.l.]: SPCB, 1999.

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Board, United States Merit Systems Protection. MSPB practices and procedures. [Washington, D.C.?]: U.S. Merit Systems Protection Board, 1986.

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Fowler, Renn C. MSPB, charges and penalties. Arlington, Va: Dewey Publications, 1999.

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Scotland. Parliament. Public Information Service., a cura di. You and your MSPs. Edinburgh: Public Information Service, 1999.

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B, Wiley William, e Federal Personnel Management Institute (Huntsville, Ala.), a cura di. Advanced MSPB practitioner's handbook. Huntsville, AL: FPMI, 2003.

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United States. Merit Systems Protection Board. An introduction to the MSPB. Washington, DC: The Board, 1999.

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Alejandro, Morelli Colombres, e Candeau Alberto, a cura di. MSP, 1985-1990. [Montevideo, Uruguay?: s.n., 1990.

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Knes, Heinz Peter, e Jonas Beuchert. E.M.T. in MSP. München: Edition Taube, 2021.

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Judy, Blair, Barrett Ruth, Shierling Maryellen e United States. Employment Standards Administration. Wage and Hour Division, a cura di. Conducting MSPA housing inspections: Resource book. [Washington, D.C.?]: U.S. Dept. of Labor, Employment Standards Administration, Wage and Hour Division, 1990.

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Gray, Barbara, e Jill Purdy. Collaborating for Our Future. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198782841.001.0001.

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Organizations turn to multistakeholder partnerships (MSPs) to meet challenges they cannot handle alone. By tapping diverse stakeholders’ resources, MSPs develop the capability to address complex issues and problems, such as health care delivery, poverty, human rights, watershed management, education, sustainability, and innovation. This book provides a comprehensive understanding of MSPs, why they are needed, the challenges partners face in working together, and how to design them effectively. Through the process of collaboration partners combine their differing strengths, vantage points, and expertise to craft innovative responses to pressing societal concerns. The book offers valuable advice for leaders about how to design and scale up effective partnerships and how to address potential obstacles partners may face, such as dealing with the conflicts and power issues likely to arise as partners negotiate with each other. Drawing on three comprehensive cases and countless shorter examples from around the world, the book offers practical advice for organizations embarking on an MSP, as well as theoretical understanding of how partnerships function. Using an institutional theory lens, it explains how partnerships can effect change in institutional fields by reducing turbulence and negotiating a common set of norms and routines to govern partners’ future interactions within the field of concern. Topics covered include: the nature of working collaboratively, why partnerships are needed, types of partnerships, guidelines for partnership design, partnerships and field dynamics, how to deal with conflicts among partners, negotiating across power differences, partnerships for sustainability, collaborative governance, working across scale differences, and how partnerships transform fields.

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Ejsmont, Krzysztof, Bartlomiej Gladysz, Natalia Roczon, Andrea Bettoni, Zeki Mert Barut, Rodolfo Haber e Elena Minisci. "Multisided Business Model for Platform Offering AI Services". In Artificial Intelligence in Manufacturing, 105–20. Cham: Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-46452-2_7.

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AbstractThe development of B2B platforms has led to the diffusion of business models (BMs) based on the concept of sharing economy. In recent years, multisided platform BMs have become an important way of creating and capturing value even though the phenomenon remains undertheorized (Zhao et al., Long Range Planning 53(4):101892, 2020). Multisided platforms (MSPs) are present in an increasing number of sectors due to the development of the Internet, digital technologies, and artificial intelligence (AI). The manufacturing sector has not been untouched by this trend; however, it still struggles to establish value drivers to support small- and medium-sized enterprises (SMEs) in the change. The objective of the proposed study is to present an ecosystem for the SME manufacturing sector, which will be based on the selected MSP offering AI services. An initial BM for the AI platform as a service will be design, and a revenue model will be proposed within it. The selected case allowed the use of a methodological approach (PDT – Platform Design Toolkit) to the design of an MSP business model based on a qualitative analysis of the dynamics governing the platform ecosystem. The originality of the research stems from the reliance on data obtained from the implementation of the KITT4SME project (H2020, GA 952119). The study results indicate that it is crucial to properly identify the needs of the platform’s stakeholders, and then precisely define the values and the mechanisms for exchanging them through MSP.

Han, Xue, Yuanyuan Wu e Jie Zheng. "Pair Comparison Between Chinese MSPs and American MSPs". In Disruptive Innovation through Digital Transformation, 69–84. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-3944-2_5.

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Kaur, Harleen. "What is MSPE?" In International Medical Graduate and the United States Medical Residency Application, 83–87. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-31045-5_14.

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Flannery, Wesley. "Making Marine Spatial Planning Matter". In Ocean Governance, 93–111. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-20740-2_5.

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AbstractOver the last decade, Marine Spatial Planning (MSP) has become one of the key components of marine governance. In the European Union, member states are working towards the development of their first plans under the Maritime Spatial Planning Directive. Internationally, UNESCO and the European Commission have launched their MSP Global initiative to speed up the implementation of MSP around the world. MSP is also framed as being a key mechanism for sustainably realising the benefits of the Blue Economy and emerging Green Deals. During this same period, however, a substantial body of critical academic work has emerged that questions whether the implementation of MSP will transform unsustainable marine governance and management practices. This scholarship illustrates that the current trajectory of many MSP initiatives is to preserve the status quo and that they fail to adequately address longstanding marine governance issues. Drawing on Flyvbjerg’s vital treatise on phronetic social science, this chapter will explore: where is MSP going; who gains and loses, and how they do so; is this desirable, and if not, what can be done to make MSP matter? I particularly focus on mechanisms of winning and losing, characterising them as key tensions in MSP processes that can be unsettled to make MSP more transformative.

Kaufman, Keith A., Carol R. Glass e Timothy R. Pineau. "Empirical support for MSPE." In Mindful sport performance enhancement: Mental training for athletes and coaches., 163–77. Washington: American Psychological Association, 2018. http://dx.doi.org/10.1037/0000048-012.

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Montemuiño, Carlos, Antonio Espinosa, Juan-Carlos Moure, Gonzalo Vera-Rodríguez, Sebastián Ramos-Onsins e Porfidio Hernández Budé. "msPar: A Parallel Coalescent Simulator". In Euro-Par 2013: Parallel Processing Workshops, 321–30. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54420-0_32.

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Coogan, Kevin, Varun Khare, Stephen G. Kobourov e Bastian Katz. "MSDR-D Network Localization Algorithm". In Algorithms for Sensor Systems, 148–60. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-16988-5_13.

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Magis, David, Duanli Yan e Alina A. von Davier. "Examples of Simulations Using mstR". In Computerized Adaptive and Multistage Testing with R, 141–60. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-69218-0_8.

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Burger, Wilhelm, e Mark J. Burge. "Maximally Stable Extremal Regions (MSER)". In Texts in Computer Science, 765–95. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-05744-1_26.

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Zou, Chunyan, Chenggang Yu, Jun Zhou, Shuning Chen, Jianhui Wu, Yang Zou, Xiangzhou Cai e Jingen Chen. "Minor Actinides Transmutation in Thermal, Epithermal and Fast Molten Salt Reactors with Very Deep Burnup". In Springer Proceedings in Physics, 656–72. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-1023-6_57.

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AbstractDeep burnup and high minor actinides (MA) loading are two alluring features for molten salt reactors (MSR) to incinerate the nuclear wastes. The transmutation capability of minor actinides in MSR is tightly related with the neutron spectrum, the loading of MA and the carrier salt compositions. In this work, three MSR core designs (thermal, epithermal and fast) and two types of salt compositions (Flibe and Flinak) with different solubility limits of transuranic elements are chosen for analyzing the transmutation capability of MA. With a significant mole fraction of MA loading (4% in the Flibe salt and 10% in the Flinak salt) and the continuous MA refueling, MSR acquires an excellent transmutation rate. The specific incineration rates of MA in the thermal, epithermal and fast MSR cores with the Flibe salt are about 167, 185 and 206 kg/GWth/y, respectively. With a larger loading of MA in the Flinak salt, a higher annual incineration rate of MA can be obtained, which are about 170, 206 and 247 kg/GWth/y in thermal, epithermal and fast MSRs, respectively. On the other hand, since there is a preferred neutron economy for the Flibe salt, a higher MA incineration ratio is achieved than that for the Flinak salt. When the neutron spectrum varies from the thermal to fast region, the MA incineration ratio ranges from 0.79 to 0.82 for the Flibe salt and it ranges from 0.75 to 0.81 for the Flinak salt. The transmutation capability of MA in MSR is much higher than that in solid-fueled reactors (~20 kg/GW.y in a PWR), which can provide a feasible way for reducing the current nuclear wastes.

Atti di convegni sul tema "MSPR":

Li, Chao, Zhefan Jin, Xiaohong Jiang e Jiaoying Shi. "MSPR: a retained-mode-based multiscreen parallel rendering system". In Fourth ionternational conference On Virtual Reality and Its Applications in Industry, a cura di Jizhou Sun e Zhigeng Pan. SPIE, 2004. http://dx.doi.org/10.1117/12.561129.

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Zhao, Jinkun, Shengyi Si, Qichang Chen e Hua Bei. "New Exploration on TMSR: Redesign of the TMSR Lattice". In 2017 25th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/icone25-66564.

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Molten Salt Reactor (MSR) has been recognized as one of the Next Generation Nuclear Power systems. Most MSR concepts are the variants evolved from the ORNL’s Molten-Salt Breeder Reactor (MSBR) which employs Molten-Salt as both fuel and coolant, and normally graphite is used as moderator. Many evaluations have revealed that such concepts have low breeding ratio and might present positive power coefficient. Facing these impediments, TMSR (Thorium Molten Salt Reactor) with redesigned lattice is proposed in this paper. Based on comprehensive investigation and screening, important lattice parameters including molten salt fuel composition, solid moderator material, lattice size, structure and lattice P/D ratio (lattice pitch to channel diameter) are redesigned. In this paper, new composition of fuel salt without BeF2, which is also recommend for Molten Salt Fast Reactor (MSFR), is employed instead of LiF-BeF2-ThF4-UF4 adopted in the design of single fluid MSBR. The new fuel composition makes TMSR to benefit from the increased solubility for actinides (e.g. Th4, UF4). Moreover, due to the decent slowing-down power and neutron multiplication effect by (n,2n) reaction of beryllium, BeO is employed as moderator to improve neutron economy instead of graphite. To avoid corrosion on the one hand, Ceramic cladding (e.g. SiC) is introduced to separate the flowing liquid fuel and fixed solid moderator. More importantly, ceramic cladding is capable of maintaining a stable flow channel and supporting the core structure on the other hand. Concerning neutron spectrum, P/D ratio is an important parameter indicating the volume fraction of fuel in the lattice. In order to obtain a suitable spectrum for better breeding and safety features, lattice size and P/D ratio have been optimized for TMSR. Furthermore, since online reprocessing capability and refueling control are key parameters influencing depletion behavior which concerns the sustainability of the reactor system, these issues are also discussed in this paper. Simulation of the redesigned TMSR system is performed to evaluate the outcomes of the lattice parameters optimization. SONG/TANG-MSR codes system is applied in the simulation, which is independently developed by Shanghai Nuclear Engineering Research & Design Institute (SNERDI). A traditional core model with LiF-BeF2-ThF4-UF4 fuel and graphite moderator is also evaluated by the codes for reference. Thanks to the optimized lattice parameters and as consequences of the redesigned lattice, TMSR has achieved a high breeding ratio close to 1.13. With a proper reprocessing and refueling strategy, the doubling time of TMSR can be shortened to about 15 years. Meanwhile a negative power coefficient is still maintained. Based on this lattice design, TMSR will have excellent performance on safety and sustainability.

Guerrieri, Claudia, Manuele Aufiero, Antonio Cammi, Carlo Fiorina e Lelio Luzzi. "A Preliminary Study of the MSFR Dynamics". In 2012 20th International Conference on Nuclear Engineering and the ASME 2012 Power Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/icone20-power2012-54521.

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In the last years, increasing interest has been focused on an innovative concept of Molten Salt Reactor (MSR) characterized by a fast neutron spectrum that combines the favorable characteristics of MSRs adopting molten salt fluorides both as fuel and coolant with those ones of fast neutron reactors. As a matter of fact, the Molten Salt Fast Reactor (MSFR) has been recognized as a long term alternative to solid-fuelled fast neutron systems and has been identified as reference Gen-IV configuration. Although considerable studies have been carried out for the analysis of the graphite-moderated MSR dynamics, the adoption of a fast spectrum configuration without graphite in the core is expected to notably modify the dynamic behavior of the system, thus requiring further investigation. In this paper, a preliminary analysis of the MSFR dynamics is performed allowing for the evaluation of the impact of some safety parameters (e.g., feedback coefficients and delayed neutron fraction) on the system behavior for different fuel cycle strategies. For this purpose, a simplified non-linear one-dimensional model of the primary circuit has been developed and the dynamic response of the system has been investigated with reference to different significant transient initiators, namely: unprotected transient overpower, unprotected loss of flow, and unprotected loss of heat sink. These analyses are thought to give a basic understanding of the MSFR dynamics, as well as significant indications in terms of the system safety parameters.

Oruko, Happiness, John Kutna, Anne Gitimu, Yvonne Opanga e Esther Wambui. "Assessing The Role of Multi-Sectoral Platforms and Their Influence on Nutrition Outcomes in West Pokot County, Kenya". In 3rd International Nutrition and Dietetics Scientific Conference. KENYA NUTRITIONISTS AND DIETICIANS INSTITUTE, 2023. http://dx.doi.org/10.57039/jnd-conf-abt-2023-f.s.s.d-04.

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Background: Various actors continue to implement food and nutrition security interventions in West Pokot. SMART Survey Report, 2022 indicates higher stunting rates of 43.2% against 26% at national level. Multisector approach offers comprehensive strategies to enhance food systems as well as food and nutrition security (FNS) through addressing underlying and basic causes of malnutrition which seem to be missed out in most nutrition interventions. The paper highlights the functionality of multi-sectorial platforms (MSP) and their influence on FNS issues in West Pokot County. Methods: A cross sectional design utilizing qualitative data collection methods was utilized. 25 Key Informant Interviews with purposively selected representatives from line ministries and implementing partners were conducted. Additionally, 9 FGDs with Community Based Organizations and Community Health Volunteers were conducted. Qualitative data was audio recorded, translated, transcribed verbatim and coded using MAXQDA version 22. Data was analyzed thematically through deductive and inductive methods. Results: Key findings indicated lack of awareness on existence and objectives of multi-sectoral platforms and County FNS priorities among stakeholders. There was minimal evidence of stakeholder participation in development of FNS priorities at subcounty and community levels, poor dissemination of FNS priorities and the MSP terms of reference. At the community level, food security was limited due to high food prices, poor road networks for food distribution as well as cultural practices that limit consumption of certain foods. It was also noted that some community members also lack awareness on food preservation leading to food wastage. Facilitating factors for MSP functionality included availability of well-established government structures and technical capacity of various stakeholders. Barriers included: inadequate financial and human resources to support MSP, minimal capacity to coordinate MSP and failure to prioritize MSP by stakeholders. Proposed sustainability mechanisms included: Need to strengthen government commitment to fund and convene MSPs, improve capacity of stakeholders to coordinate MSP, and institutionalize MSP in line ministries. Conclusion: There is need to improve inclusivity of all stakeholders in MSP processes including design, implementation and monitoring. To ensure sustainability, there is need to enhance government commitment and stakeholder contribution in co-funding MSP activities. Key Words: Stunting, Multi-sectoral platform, Food and Nutrition Security, co-funding, Sustainability

Zhang, Dalin, Zhi-Gang Zhai, Andrei Rineiski, Zhangpeng Guo, Chenglong Wang, Yao Xiao e Suizheng Qiu. "COUPLE, A Time-Dependent Coupled Neutronics and Thermal-Hydraulics Code, and its Application to MSFR". In 2014 22nd International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/icone22-30609.

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Molten salt reactor (MSR) using liquid fuel is one of the Generation-IV candidate reactors. Its liquid fuel characteristics are fundamentally different from those of the conventional solid-fuel reactors, especially the much stronger neutronics and thermal hydraulics coupling is drawing significant attention. In this study, the fundamental thermal hydraulic model, neutronic model, and some auxiliary models were established for the liquid-fuel reactors, and a time-dependent coupled neutronics and thermal hydraulics code named COUPLE was developed to solve the mathematic models by the numerical method. After the code was verified, it was applied to the molten salt fast reactor (MSFR) to perform the steady state calculation. The distributions of the neutron fluxes, delayed neutron precursors, velocity, and temperature were obtained and presented. The results show that the liquid fuel flow affects the delayed neutron precursors significantly, while slightly influences the neutron fluxes. The flow in the MSFR core generates a vortex near the fertile tank, which leads to the maximal temperature about 1100 K at the centre of the vortex. The results can provide some useful information for the reactor optimization.

Cherkaoui, Soumaya, e Omar Lahlou. "MSBR". In the 2nd ACM international workshop. New York, New York, USA: ACM Press, 2006. http://dx.doi.org/10.1145/1163673.1163697.

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Wang, Xiang, e Rafael Macian-Juan. "Comparative Study of Basic Reactor Physics of the DFR Concept Using U-Pu and TRU Fuel Salts". In 2017 25th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/icone25-66035.

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The Dual Fluid Reactor (DFR) is a molten salt fast reactor developed by the IFK1 based on the Gen-IV Molten-Salt Reactor (MSR) and the Liquid-Metal Cooled Reactor (SFR, LFR) concepts. The analysis reported focuses on the comparison between previous neutronic calculations with the default fuel salt of U-Pu mixture and new ones with a transuranium (TRU) salt fuel option under steady state conditions. They include criticality, neutron spectrum, spatial flux distribution and temperature coefficient values. Fuel based on molten TRU salts has already been considered for the MSFR and other molten salt reactor designs. Therefore, the DFR for the first time has a comparable baseline with other molten salt reactors, so that its performance with TRU salt fuel can be assessed.

Xu, Hailiang, Siqi Xie e Fan Chen. "Fast MSER". In 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR). IEEE, 2020. http://dx.doi.org/10.1109/cvpr42600.2020.00344.

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Liu, Yafen, Rui Guo, Xiangzhou Cai, Rui Yan, Yang Zou e Bo Zhou. "Breeding Properties Study on High Power Thorium Molten Salt Reactor". In 2017 25th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/icone25-66961.

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The Molten Salt Reactor (MSR), the only one using liquid fuel in the six types ‘Generation IV’ reactors, is very different from reactors in operation now and has initiated very extensive interests all over the world. This paper is primarily aimed at investigating the breeding characteristics of high power (1000 MWe) Thorium Molten Salt Reactor (TMSR) based on the two-fluid Molten Salt Breeder Reactor (MSBR) with superior breeding performance. We explored the optimized structure to be a thorium based molten salt breeder reactor with different core conditions and different post-processing programs, and finally got the breeding ratio of 1.065 in our TMSR model. At last we analyzed the transient security of our optimized model with results show that the temperature coefficient of core is −3 pcm/K and a 2000 pcm reactivity insertion can be successfully absorbed by the core if the insertion time is more than or equal to 5 seconds and the core behaves safely.

Zhong, Ziguo, e Tian He. "MSP". In the 5th international conference. New York, New York, USA: ACM Press, 2007. http://dx.doi.org/10.1145/1322263.1322266.

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Rapporti di organizzazioni sul tema "MSPR":

Shahbazi, Shayan, Mauricio Tano, Samuel Walker, Michael Tonks e Jun Fang. Survey of Relevant Data from the MSRP to Guide Development of MSR Chemistry Modeling Benchmarks. Office of Scientific and Technical Information (OSTI), settembre 2022. http://dx.doi.org/10.2172/1962308.

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Hajj, Ramez, e Babak Asadi. Review of Illinois Multiple Stress Creep and Recovery Data for Future Implementation. Illinois Center for Transportation, dicembre 2023. http://dx.doi.org/10.36501/0197-9191/23-027.

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The multiple stress creep recovery (MSCR) test, per AASHTO M 332, or as a supplement to M 320, has been widely implemented across the United States and in other parts of the world for assessing the rutting resistance of asphalt binder. Meanwhile, the Illinois Department of Transportation (IDOT) has conducted wide-ranging MSCR testing since 2006 but has not yet implemented this test into the binder specification, which utilizes AASHTO M 320 with other PG Plus tests for modified asphalt binder. This report presents a review of the existing literature and an update of specifications in the United States for the rutting resistance of asphalt binder. The report also presents an analysis of existing MSCR data collected by IDOT and a machine learning model with the ability to predict asphalt binder elastic recovery using MSCR. This model demonstrated the potential effectiveness of MSCR to serve as an appropriate surrogate for this test, but further study is needed of Illinois mixture performance compared to MSCR to best understand how this specification can be implemented for local materials and traffic levels.

Brayton, Kelly A., Varda Shkap, Guy H. Palmer, Wendy C. Brown e Thea Molad. Control of Bovine Anaplasmosis: Protective Capacity of the MSP2 Allelic Repertoire. United States Department of Agriculture, gennaio 2014. http://dx.doi.org/10.32747/2014.7699838.bard.

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Anaplasmosis is an arthropod-borne disease of cattle caused by the rickettsia Anaplasmamarginale and is an impediment to efficient production of healthy livestock in both Israel and the United States. Currently, the only effective vaccines are derived from the blood of infected cattle. The risk of widespread transmission of both known and newly emergent pathogens has prevented licensure of live blood-based vaccines in the U.S. and is a major concern for their continued use in Israel. Consequently, development of a safe, effective vaccine is a high priority. Despite its drawbacks as a live, blood-based vaccine, the Israel vaccine strain protects against disease upon challenge with wild-type A. marginale in extensive experimental trials and during 50 years of deployment in Israel. Field studies in Australia and Argentina indicate that this protection is broadly effective. Thus, to identify antigens for development of a safe and effective recombinant vaccine, we have used a comparative genomics approach by sequencing the Israel vaccine strain and searching for shared surface antigens with sequenced wild-type U.S. strains. We have focused on Msp2, the immune-dominant but antigenically variable surface protein, based on shared structure among strains and demonstration that antibody from cattle immunized with the Israel vaccine strain binds Msp2 from the genetically and geographically distinct U.S. St. Maries strain, consistent with the ability to protect against St. Maries challenge. Importantly, we have defined the full repertoire of Msp2 simple variants encoded by the vaccine strain and hypothesize that a recombinant vaccine encoding this full repertoire will induce protection equivalent to that induced by the live vaccine strain. Any escape from immunity by generation of complex Msp2 variants is predicted to carry a severe fitness cost that prevents high-level bacteremia and disease— consistent with the type of protection induced by the live vaccine strain. We tested the hypothesis that the Msp2 simple variant repertoires in wild-type A. marginale strains are recognized by antibody from cattle immunized with the Israel vaccine strain and that immunization with the vaccine strain Msp2 repertoire can recapitulate the protection provided by the vaccine strain upon challenge with Israel and U.S. strains of A. marginale. Our findings demonstrate that a set of conserved outer membrane proteins are recognized by immune serum from A. centrale vaccinated animals but that this set of proteins does not include Msp2. These findings suggest that “subdominant” immunogens are required for vaccine induced protection.

Henderson, J. R., e M. E. Zelinski. UNESE MSIR Summary, FY15-FY16. Office of Scientific and Technical Information (OSTI), luglio 2016. http://dx.doi.org/10.2172/1289385.

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Palmer, Guy H., Eugene Pipano, Terry F. McElwain, Varda Shkap e Donald P. Knowles, Jr. Development of a Multivalent ISCOM Vaccine against Anaplasmosis. United States Department of Agriculture, luglio 1993. http://dx.doi.org/10.32747/1993.7568763.bard.

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Anaplasmosis is an arthropod+borne disease of cattle caused by the rickettsia Anaplasma marginale and an impediment to efficient production of healthy livestock in both Israel and the United States. Our research focuses on development of a recombinant membrane surface protein (MSP) immunogen to replace current vaccines derived from the blood of infected cattle. The risk of widespread transmission of both known and newly emergent pathogens has prevented licensure of live blood-based vaccines in the U.S. and is a major concern for their continued use in Israel. Briefly, we accomplished the following in our BARD supported research: i) characterization of the intramolecular and intermolecular relationships of the native Major Surface Proteins (MSP) in the outer membrane; ii) expression, purification, and epitope characterization of the recombinant MSP-2, MSP-3, MSP-4, and MSP-5 proteins required to construct the recombinant ISCOM; iii) demonstration that the outer membrane-Quil A induces CD4+ T lymphocytes specific for the outer membrane polypeptides; iv) identification of CD4+ T lymphocytes that recognize outer membrane polypeptide epitopes conserved among other wise antigenically distinct strains; v) determination that immunization with the outer membrane-Quil A construct does not affect the ability of ticks to acquire or transmit A. marginale; and vi) demonstration that the outer membrane-Quil A construct induces complete protection against rickettsemia upon homologous challenge and significant protection against challenge with antigenically distinct strains, including tick transmission. Importantly, the level of protection against homologous challenge in the MSP vaccinates was comparable to that induced by live blood-based vaccines and demonstrates that development of a new generation of vaccines is feasible.

Campbell, B., R. Mahy e C. Jennings, a cura di. The Message Session Relay Protocol (MSRP). RFC Editor, settembre 2007. http://dx.doi.org/10.17487/rfc4975.

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Holcomb, David, Willis Poore III e George Flanagan. MSR Fuel Qualification Methodology. Office of Scientific and Technical Information (OSTI), luglio 2020. http://dx.doi.org/10.2172/1649079.

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Holcomb, David. MSR Promise and Challenge. Office of Scientific and Technical Information (OSTI), novembre 2023. http://dx.doi.org/10.2172/2367289.

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Holcomb, David. MSR History, Promise, and Challenges. Office of Scientific and Technical Information (OSTI), marzo 2024. http://dx.doi.org/10.2172/2356769.

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Holmberg, C. Message Session Relay Protocol (MSRP) over Data Channels. RFC Editor, gennaio 2021. http://dx.doi.org/10.17487/rfc8873.

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