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Sorice, Gabriele. ""Huon de Bordeaux" in alessandrini (ms. Paris, BnF, fr. 1451): edizione critica con glossario e note di commento". Doctoral thesis, University of Trento, 2019. http://eprints-phd.biblio.unitn.it/3542/1/TESI_SORICE.pdf.
Testo completoBueno, Mara Lucinéia Marques Corrêa. "ENSINO FUNDAMENTAL DE NOVE ANOS: IMPLEMENTAÇÃO E ORGANIZAÇÃO ESCOLAR EM DOURADOS/MS". UNIVERSIDADE FEDERAL DA GRANDE DOURADOS, 2010. http://tede.ufgd.edu.br:8080/tede/handle/tede/55.
Testo completoThis research intended to answer to the question: how was the implementation of the extension of the obligedness politics of the fundamental schooling given for the six year-old population in municipal schools of Dourados, Mato Grosso do Sul. The objective was to know the local configuration of that politics in relation to municipal and national regulations and orientations, with special attention to the measures taken by the schools concerning the organization of time, space and curriculum. For so much, it was accomplished a qualitative investigation in the three municipal schools that obtained the largest numbers of registrations in the first year in the fundamental teaching during the years of 2007 to 2009. It was used information obtained through interviewing pedagogic coordinators and responsible technicians for the fundamental teaching in the Municipal Bureau of Education of Dourados submitted to content analysis. Those information were compared with national and municipal official legislation, regulation and orientations, by document analysis. The qualitative approach was enriched with statistical data from INEP and by consultation to bibliographical sources about the subject. The results showed that in the observed municipal schools the implementation of the politics in focus is recent, being marked by the improvisation, for the lack of infrastructure and pedagogic conditions that difficult the organization of space, time and curriculum in consonance with national orientations. Few were the changes in the school atmosphere to assist the six year-old child. Thus, the educational installment propitiated by the extension of the fundamental teaching politics implemented in Dourados hasn t been effecting the child's fundamental rights assured in the legal sphere and evidence the scarce local consequence of MEC initiatives
Esta pesquisa buscou responder à pergunta: como se deu a implementação da política de extensão da obrigatoriedade do ensino fundamental para a população de seis anos de idade em escolas municipais de Dourados estado de Mato Grosso do Sul? O objetivo foi conhecer a configuração local dessa política vista em relação às regulamentações e orientações municipais e nacionais, com especial atenção às medidas tomadas pelas escolas no tocante à organização do tempo, espaço e currículo. Para tanto, realizei investigação qualitativa em três escolas municipais, que obtiveram maior número de matrículas no primeiro ano no ensino fundamental entre os anos de 2007 e 2009. Utilizei informações obtidas por meio de entrevistas a coordenadores pedagógicos e técnico responsável pelo ensino fundamental na Secretaria Municipal de Educação de Dourados valendo-me da análise de conteúdo. Essas informações foram cotejadas com legislação, regulamentação e orientações oficiais nacionais e municipais, por meio de análise de documento. A abordagem qualitativa foi enriquecida com dados estatísticos do INEP e pela consulta a fontes bibliográficas que tratam da questão. A pesquisa mostrou que nas escolas municipais observadas a implementação da política em foco é recente, sendo marcada pela improvisação, pela falta de condições infraestruturais e pedagógicas que entravam a organização do espaço, do tempo e currículo em consonância com orientações nacionais. Poucas foram as mudanças ocorridas no ambiente escolar para atender à criança de seis anos de idade. Desse modo, a prestação educacional propiciada pela política de extensão do ensino fundamental implementada no município tem deixado de efetivar direitos fundamentais da criança assegurados na esfera legal e evidenciado a escassa consequência local das iniciativas do MEC.
Thekedar, Bhushan. "Investigations on the use of breath gas analysis with Proton Transfer Reaction Mass Spectrometry (PTR-MS) for a non-invasive method of early lung cancer detection". kostenfrei, 2009. https://mediatum2.ub.tum.de/node?id=821780.
Testo completoFilho, William Sallun. "Geomorfologia e geoespeleologia do carste da Serra da Bodoquena, MS". Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/44/44134/tde-19112015-093950/.
Testo completoThe Bodoquena plateau, developed over the Corumbá Group (Neoproterozoic III - Paraguai Fold Belt), is a carbonate rock highland relative to the non carbonate lowlands of the Mato Grosso do Sul State, mid-western Brazil. Based on 1:60.000 scale morphological analysis of the karst topography, three main compartments were defined. The first one is a mixed recharge karst landforms, developed over limestone of the Bodoquena plateau. The second unit is characterized by essentially autogenic recharge, residual hills and karstic plains with dolines, developed mainly over dolomites of the Miranda river depression (lowlands). The third one, characterizes an interstratatl karst system in proterozoic limestones overlain by sandstones of the Aquidauana Formation of the Phanerozoic Paraná basin. This geomorphological unit is localized at the southern extremity of the Bodoquena plateau, exhibiting flat topography, with frequent dolines in sandstone, of up to 700 m in diameter. Although the Bodoquena karst system is well developed, as can be inferred based on the presence of several vauclusian springs, blind valleys in the northwest border, dolines and a deep conduit aquifer evidenced through productive water wells, the cave incidence is low as are their dimensions, considering the large carbonate rock exposure. Four cave patters were recognized, which are related to the above geomorphological units: 1) large irregular breakdown halls in plain view and dipping planes in longitudinal section (following bedding and joint surfaces), which frequently reach up to 90 m beneath the water table, sometimes with large lakes, as for example, the Lago Azul cave (Bonito municipality). This pattern is the most frequent cave type of the second unit, occurring at the dolomitic residual hills with karst plains; 2) network caves with anastomotic pattern in plan view and circular to elliptical conduits with lateral anastomosis in cross section. They occur mostly associated with the labyrinth and polygonal karst topography of the first morphological unit and rarely with the unit of residual hills and plains; 3) caves with meandering conduits in plan view, sometimes with active or inactive allogenic stream sinks, associated with the polygonal and labyrinth karst topography; 4) Steep dipping phreatic conduits, characterizing vauclusian springs, occurring at the limestone plain along the base of the eastern escarpment of the Bodoquena plateau. The recent tectonic activity along the Bodoquena plateau area was detected by the following features: vadose speleothems submerged at least 16 m beneath the lowest seasonal water level stage; limestone highland with the escarpment beside dolomitic lowlands; northern part of the carbonate plateau with deep entrenched river valleys in contrast with the southern sector of open valleys and less entrenchment; linear structure observed in 1:250.000 scale which marks the border of the Pantanal basin and crosses the Bodoquena plateau.
Sauwala, Laetitia. "Édition critique du Mystère des trois doms (ms BnF n.a.f. 18995). Analyse linguistique, glossaire et notes". Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCA138.
Testo completoThis thesis presents a critical edition of the Mystère des Trois Doms (1509), from a single manuscript now kept in the National Library of France under the reference n.a.f 18995. This drama play in Middle French contains approximately 11,000 verses, and tells the conversion and martyrdom of the three patron saints of the town of Romans, Séverin, Exupère and Félicien; it was composed for a performance, which took place in the city during three days, on 27, 28 and 29 May 1509. Our work includes several distinct and complementary aspects: philological and historical analysis, literary presentation and linguistic study. After presenting the objectives of our work, we analyze the preparation of the 1509 performance, from a writing point of view (analysis of the manuscript and the various stages of its composition) as well as from the material realization of the representation (construction of the theater and scenery). Indeed, we also have the book of accounts of the mystery play, which contains valuable informations on organizational modalities of its representation: it is a unique case, making this text of great importance for the history of the theater in France. We then propose a presentation of the text of the mystery, an analysis of sources, staging, and some elements of versification and stylistics. The language of the mystery being very rich, our linguistic study focuses on several aspects: graphics systems of the different scribes, regionality of the language and representation of orality. Finally, we present the principles that guided our critical edition of the three days of the play, followed by an account of the various variants and corrections contained in the manuscript, some notes on the text, a glossary and a bibliography. The appendices of the volume also contain several boards of the manuscript
Zaine, Mariselma Ferreira. "Análise de fósseis de parte da faixa Paraguai (ms,mt) e seu contexto temporal e paleoambiental". Universidade de São Paulo, 1991. http://www.teses.usp.br/teses/disponiveis/44/44136/tde-31032015-110745/.
Testo completoThis dissertation describles fossils and their temporal and paleoenvironmental contexts from the Jacadigo and Corumbá Groups and Araras and Raizama Formations of the Paraguai Belt in the regions of Corumbá and Bonito/serra da Bodoquena, Mato Grosso do Sul, Cáceres and Bauxi/Jangada in Mato Grosso, in Central-Western Brazil. The paleontologic record of these sequences is of great importance for a better understanding of the Proterozoic Cambrian transition in Brazil. The fossils studied include metazoans, metaphytes, organic-walled microfossils, ichnofossils and stromatolites, all of rather limited occurrence. Within the Jacadigo Group, vase-shaped microfossils apparently restrict the age of the carbonate clasts in which they occur to the interval between 700 and 950 Ma. Greater paleontological diversity is displayed by the overlyng Corumbá Group in the form of metazoans (Cloudina Lucianoi and Corumbella werneri), metaphytes (tyrasotaenia sp.) and microfossils (Sphaerocongregus variabilis), that together point to a latest Vendian age at least for the uppermost part of this sedimentary sequence. In the Araras Formation, a lateral equivalent of the Corumbá Group, stromatolites provide no significant indication of age but are of considerable paleoenvironmental interest and may be useful in local correlation. Above the Araras Formation, in the Raizama Formation, simple, horizontal ichnofossils are here registered for the first time in the Paraguai Belt and are forms known elsewhere from the end of the Proterozoic although not necessarily restricted to this eon. Isotopic analyses of the stable isotopes of C in limestone of the Corumbá Group and Araras Formation furnished \'delta\'\'ANTPOT.18 C\' values consistent with those exhibited by other terminal Vendian sequences in the world, they also complement paleoenvironmental studies, together with evidence derived from study of lithologies, sedimentary structures and a few analyses of \'delta\'\'ANTPOT.18 O\'. Isotopic compositions of Sr for many of the same samples analysed for C and O fall within the general range of values known for the Late Proterozoic, in conjunction with the associated fossil evidence, however, they appear to be consistent with a more restricted interval at the end of this eon.
VASTEL, JACQUELINE. "Recherches sur la dramaturgie et la spiritualite des miracles de notre dame par personnage du ms. Cange". Caen, 1994. http://www.theses.fr/1994CAEN1145.
Testo completoOur purpose is to establish the kinds of bonds existing between the dramatic art of the forty miracles de notre dame par personnages and the spiritual conception of their sleeping partners. At first, we recall the conjoncture space in wich those miracles were played : the religious theme is not unimportant in the plays, as they were stage from 1339 to 1382 and that their sleeping partners were the rich confrerie des orfevres de paris. Thus we evoke the conjoncture in which they were born : the one hundrerd years war, the economic situation and especially the religious context, the increasing power of the parisian burgesses and, more particulary the corporation of goldsmiths. After, the main characteristics of the recueil du cange are presented. Those forty miracles have a striking common point : god and or the virgin always break in - although in varied degrees - on their dramatic art. Those divine interventions always appear justified because of the bonds between creator and creature, by the creator's sight of his creature's attitude : about the respect it should have towards creator and about the others god's creatures from whom life interfere with its one's it always must have in its mind that its eternal salvation is at stake ; the divine interventions are intended to remind them for it. Between them, exist a contract : the eternal contract. Then we define the methodology used for the individual analysis of miracles with a view to
Mirats, Christine. "Le manuscrit 4. 123 de la biblioteca nacional de Madrid : édition critique, introduction et notes". Toulouse 2, 1988. http://www.theses.fr/1988TOU20015.
Testo completoThe manuscript 4. 123 from biblioteca nacional de madrid includes sixty-six "bailes", collected together and transcribed during the second half of seventeenth century by bernardo lopez del campo, actor and writer who died at grenada in 1705. In the introduction part, i suggest a definition for "baile" in the 16th and 17th centuries, then i explain the remarks on the transcription and on the edition. Next, i suggest a transcription for the first thirty "bailes" of the manuscript, metric pattern and critical notes for each of them as well. This critical edition also includes : the list of reference books ; the index of notes ; the index of proverbs for the thirty "bailes" which i have transcribed ; the index of first lines for the sixty-six "bailes" including authors names except for the anonymous "bailes" ; the index of titles for the sixty-six "bailes" of manuscript 4. 123
Silva, Eduard Lopes da. "Geologia da região da Serra da Alegria, extremo Sul do Cráton Amazônico, município de Porto Murtinho - MS". Universidade de São Paulo, 1998. http://www.teses.usp.br/teses/disponiveis/44/44135/tde-28092015-151933/.
Testo completoThe Serra da Alegria region with an area of 830 km² is a part of the southernmost extremity of the Amazon Craton (Cráton Amazônico) located in Mato Grosso do Sul State, Brazil. It was studied by fieldwork and photogeology as well as by mineralogical, petrographical and geochemical laboratory methods. A regional lithostructural reconnaissance map at a scale of 1:100.000 and results concerning the Precambrian geological evolution and metallogenesis are presented. From W to E the study area encopasses the transition from stable Archean parts of the Craton to the adjoining portions of the Proterozoic mobile belt comprising the Alto Tererê Metamorphic Association (Associação Metamórfica do Alto Tererê) of the Rio Apa Complex (Complexo Rio Apa). According to the main lithostrutural features, the area was subdivided in into Western, Central and Eastern sectors. The Western and Central sectors are composed a regionally continuous major sialic crustal segment of high-grade polymetamorphic TTG-gneisses and intrusive TTG-metagranitoids. As minor tectonic inliers they host supracrustal rocks having greenstone-belt characteristics named the Basic Metavulcano-Sedimentary Sequence (Seqüência Metavulcano-Sedimentar Básica). Basal portions of the supracrustal sequence include basic metavolcanics, now amphibolites, with well-preserved pillow lava structures and geochemical properties of ocean floor tholeiites, associated with mafic schists derived from basic to intermediate tuffs. The differentiated plutonic to hypabyssal igneous intrusion of the Serra da Alegria forms the most prominent geomorphological marker of the study area. It intruded the sialic basement rocks throughout the northern half of the Central Sector, extending regionally to the north far beyond this sector. There occur two genetically unrelated anorogenic magmatic series locally involved in magmatic mixing and contamination processes. The first one comprises major cumulate and layered gabbros and anorthosites as well as minor felsic differentiates (as veins intruding the gabbros). These rocks formed by magma chamber differentiation through fractional crystallization under rather shallow crustal conditions (as shown by Sr-fractionation in the anorthosite plagioclases), from upper mantle tholeiitic gabbroic parental magmas subjected to the fractionation processes during mantle ascent. The second series consists of a huge amount of younger granophyres. These are felsic rocks of alkaline affinities inferred to have originated from lower-crust magmas. Acid metavolcanics and subvolcanics and metadiabases complete the regional petrographic spectrum. The petrogenesis of the acid metavolcanics, which include decites/rhyodacites and rhyolites, is still problematical, since only ambiguous evidence was found regarding their mutual relationships and those with the metagranophyres of the Serra da Alegria Intrusion. The metadiabases were observed in only two occurrences; they are low-grade metamorphic rocks considered to be the youngest Precambrian rocks of the region. Throughout the Eastern Sector occurs an intimate association of granitic gneisses and metapelitic to quartzose schists prominently tectonized, also including probable equivalents of rocks of the adjoining Central and Western sectors. The Eastern Sector represents a parautochtonous to allochtonous, E-to-W transported block, structured and amplaced in the course of the younger orogenic processes of the Proterozoic mobile belst. Progressive regional metamorphism from W to E in this sector is medium grade and reached - in the extreme E in this sector - maximum conditions, transitional from medium to upper amphibolite facies. The main regional matallotects are the Metabasic Volcano-Sedimentary Sequence of greenstone-belt characteristics and the Differentiated Layered Cu anomalies and an inferred potentiality for gold and base metals. The latter shows traces of platinum minerals in heterogeneous Cr-richer gabbros and an inferred potentiality for stratiform chromities and magmatic sulphides of the Ni-Cu-Fe type, among others, related to basic-ultrabasic and ultramafic lower portions of the intrusion. The Precambrian geotectonic evolution comprises four major events including three orogenic cycles: 1)-formation of the polymetamorphic TTG-gneisses and possibly the intrusive TTG-metagranitoids in the course of one or more Archean processes of high-grade metamorphism and crustal anataxis; 2)-generation and tectiono-metamorphic collapse of the oceanic (possibly back-arc) basin of the Metabasic Volcano-Sedimentary Sequence of greenstone-belt characteristics of Archean or Palaeoproterozoic age; 3)-emplacement and magmatic evolution of the layered intrusion of the Serra da Alegria in a period of crustal stability and tectonic calm of Paleo- to Mesoproterozoic age, including perhaps, as a final stage, the acid metavolcanics, and (4)-regional mobile belt development of the Alto Tererê Metamorphic Association affecting mainly the rocks of the Eastern Sector of the study area, with a Mesoproterozoic minimum age (of 1.7-1.6 Ga), as reported in geochronological studies in the literature.
Filho, Edvard Elias de Souza. "Aspectos da geologia e estatigrafia dos depósitos sedimentares do Rio Paraná entre Porto Primavera (MS) e Guaira (PR)". Universidade de São Paulo, 1993. http://www.teses.usp.br/teses/disponiveis/44/44136/tde-02042015-144458/.
Testo completoThis research deals with geological mapping and stratigraphy of the Parana river deposits on the reach between Porto Primavera (MS) and Guaira (PR). The geological mapping was based on MSS and RADAR image interpretation and aerial-photo analysis, besides field work in which outcrops and cores were analysed. Field work had been concentrated in the area between Porto Rico and Porto Camargo (PR). Additional data have been supplied by well records from CESP (Porto Primavera) and DALCON (Porto Camargo). The available data were analysed through longitudinal and transversal topographic profiles and geological and stratigraphic crossections. The studied deposits occur in four different levels of terraces and in the active channel. The \"high terrace\" is constituted of gravel deposits of braided channel of Scott type (fluvial sequence SFa) covered with massive sands of colluvial sequence SCa. The \"medium terrace\" is constituted of gravel deposits of braided channel of Donjek Type (fluvial sequence SFb) covered with massive sands and mud ponds of colluvial sequence SCb. The \"low terrace\" is constituted of channel shape and tabular sand bed forms deposited by braided channel of Platte type. The fluvial plain is the lowest terrace and contains pebble deposits of Donjek braided channels covered with sand bed forms deposited by Platte braided channels which have been covered by mud and sand deposited in flood plain, channel and natural levee of anastomosed fluvial system. All the terraces may show alluvial fan and colluvial deposits covering parts of their surface (colluvial bars and lag deposits distributes in two levels into the channel). The hydrologic and faciologic present day characteristic of Parana river enable us to compare them South SasKatchewan braided river. The sedimentary deposits have developed through cyclic climatic changes (humid and dry phases) and under tectonic influence. Active than the alluvial systems. On the other hand, in dry periods the situation was reverted. Tectonic events have tilted the block confined by fault strutures and controlling the valley slope. According to geomorphological correlations the deposits are Quaternary in age, but palinological evidence suggests Pliocene age for the oldest deposits.
Hidalgo, Renata Lourenço Lopes. "Análise micropaleontológica das Formações Tamengo e Guaicurus, Grupo Corumbá (MS) e Formação Araras (MT), Transição do Neoproterozóico - Fanerozóico". Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/44/44136/tde-31032015-094214/.
Testo completoThe presente study documents the palynological record of the Tamengo, Guaicurus and Araras formations of the Paraguai Belt in the region of Corumbá (MS) and Cáceres (MT), west central Brazil, and interprets its temporal and paleoenvironmental context. In the Tamengo Formation the importance of the microfossil Bavlinella faveolata, considered typical of the Vendian, was confirmed. Other microfossils registered for the first time in this formation are Eonthophysalis croxfordii, two species of Siphonophicus, Helicothricoides waltheri, Leiosphaeridia crassa, as well as additimal possible acritich. In the Guaicurus Formation, no microfossils were observed but four multicellular organismos were registered: the algal Eoholynia mosquensis and Enteromorphites siniansis and two possible metazoans of unknow affinities, metazoan sp. 1 and meazoan sp.2. In the Araras Formation, the following microfossils were found for the first time: Bavlinella favellata, a species Siphonophycus (both of which also acens in the Tamengo Formation), Symplassophaeridum sp., two species of Leiosphaeridia, Soldadophycus bossii, and possible scallesor spikes of a warm like metazoan, plus possible organobacterial filaments. These fossils together with stratigraphic and sedimentologia data, allowed the Tamengo Formation to be correlated in the Laginha and Ladário quarries. They also allow tentative, more specific correlation between the Tameng and A formations, based on the presence of presumably chronocorrelative cap carbonates in the basal part the Corumbá Group and immediately beneath the Arara Formation. It is concluded that sedimentation the graten part of the C.G. And Araras Formation was penecontemporaneos at the and of the Neoproterozoic, specifically during the Vendian.
Burian, Cosmin. "Improvement of ms based e-nose performances by incorporation of chromatographic retention time as a new data dimension". Doctoral thesis, Universitat Rovira i Virgili, 2010. http://hdl.handle.net/10803/8482.
Testo completoLa importancia del sentido de olor en la naturaleza y en la sociedad humana queda latente con el gran interés que se muestra en el análisis del olor y el gusto en la industria alimentaria. Aunque las aéreas mas interesadas son las de la alimentación y bebida, también se ha mostrado la necesitad para esta tecnología en otros campos como en el de la cosmética. Lamentablemente, el uso de los paneles sensoriales humanos o paneles caninos son costosos, propensos al cansancio, subjetivos, poco fiables e inadecuados para cuantificar, mientras que el análisis de laboratorio, a pesar de la precisión, imparcialidad y capacidad cuantitativa, necesita una labor intensa, con personal especializado y requiere de mucho tiempo. Debido a estos inconvenientes el concepto de olfato artificial generó un gran interés en entornos industriales.
El término "nariz electrónica" se asocia con una serie de sensores de gases químicos, con una amplia superposición de selectividad para las mediciones de compuestos volátiles en combinación con los instrumentos informáticos de análisis de datos. La nariz electrónica se utiliza para proporcionar una información comparativa en vez de una cualitativa en un análisis, y porque la interpretación puede ser automatizada, el dispositivo es adecuado para el control de calidad y análisis. A pesar de algunos logros prometedores, los sensores de estado sólido de gas no han cumplido con sus expectativas. La baja sensibilidad y selectividad, la corta vida del sensor, la calibración difícil y los problemas de deriva han demostrado serias limitaciones. En un esfuerzo para mejorar los inconvenientes de los sensores de estado sólido, se han adoptado nuevos enfoques, utilizando diferentes sensores para la nariz electrónica. Sistemas de sensores ópticos, la espectrometría de movilidad iónica y la espectrometría infrarroja son ejemplos de técnicas que han sido probadas.
Las narices electrónicas basadas en la espectrometría de masas (MS) aparecieron por primera vez en 1998 [B. Dittmann, S. y G. Nitz Horner. Adv. Food Sci. 20 (1998), p. 115], y representan un salto importante en la sensibilidad, retando a la nariz electrónica basada en sensores químicos. Este nuevo enfoque del concepto de una nariz electrónica usa sensores virtuales en forma de proporciones m/z. Una huella digital compleja y muy reproducible se obtiene en forma de un espectro de masas, que se procesa mediante algoritmos de reconocimiento de patrones para la clasificación y cuantificación. A pesar de que la nariz electrónica basada en la espectrometría de masas supera a la nariz electrónica clásica de sensores de estado sólido en muchos aspectos, su uso se limita actualmente a la instrumentación de laboratorio de escritorio. La falta de portabilidad no representará necesariamente un problema en el futuro, dado que espectrómetros de masas en miniatura se han fabricado ya en una fase de prototipado.
Un inconveniente más crítico de la nariz electrónica basada en MS consiste en la manera en la que se analizan las muestras. La fragmentación simultánea de mezclas complejas de isómeros pueden producir resultados muy similares a raíz de este enfoque. Una nariz electrónica mejor sería la que combina la sensibilidad y el poder de identificación del detector de masas con la capacidad de separación de la cromatografía de gases. El principal inconveniente de este enfoque es de nuevo el coste y la falta de portabilidad de los equipos. Además de los problemas anteriores con la espectrometría de masas, el análisis de cromatografía de gases requiere mucho tiempo de medida.
Para abordar estas cuestiones, se han reportado miniaturizaciones en cromatografía capilar de gases (GC) que hacen posible el GC-en-un-chip, CG-rápido y CG-flash que hacen uso de columnas cortas, reduciendo el tiempo de análisis a los tiempos de elución como segundos y, en algunos casos, se han comercializado. La miniaturización de la espectrometría de masas y cromatografía de gases tiene un gran potencial para mejorar el rendimiento, la utilidad y la accesibilidad de la nueva generación de narices electrónicas.
Esta tesis se dedica al estudio y a la evaluación del enfoque del GC-MS para la nariz electrónica como un paso anterior al desarrollo de las tecnologías mencionadas anteriormente. El objetivo principal de la tesis es de estudiar si el tiempo de retención de una separación de cromatografía puede mejorar el rendimiento de la nariz electrónica basada en MS, mostrando que la adición de una tercera dimensión trae más información, ayudando a la clasificación de las pruebas. Esto se puede hacer de dos maneras:
· comparando el análisis de datos de dos vías de espectrometría de masas con análisis de datos de dos vías de matrices desplegadas y concatenadas para los datos de tres vías y
· comparando el análisis de datos de dos vías del espectrometría de masas con el análisis de datos de tres vías para el conjunto de datos tridimensionales.
Desde el punto de vista de cromatografía, la meta será la de optimizar el método cromatográfico con el fin de reducir el tiempo de análisis a un mínimo sin dejar de tener resultados aceptables.
Un paso importante en el análisis de datos multivariados de vías múltiples es el preprocesamiento de datos. Debido a este objetivo, el último objetivo será el de determinar qué técnicas de preprocesamiento son las mejores para y el análisis de dos y tres vías de datos.
Con el fin de alcanzar los objetivos propuestos se crearon dos grupos de datos. El primero consiste en las mezclas de nueve isómeros de dimetilfenol y etilfenol. La razón de esta elección fue la similitud de los espectros de masas entre sí. De esta manera la nariz electrónica basada en espectrometría de masas sería retada por el conjunto de datos. También teniendo en cuenta el tiempo de retención de los nueve isómeros solos, las soluciones se hicieron, como si el conjunto de datos demostraría el reto si se usaría sólo el tiempo de retención. Por tanto, este conjunto de datos "artificiales" sostiene nuestras esperanzas en mostrar las mejoras de la utilización de ambas dimensiones, la MS (espectros de masas) y la GC (tiempo de retención).
Veinte clases, representando las soluciones de los nueve isómeros se midieron en diez repeticiones cada una, por tres métodos cromatográficos, dando un total de 600 mediciones. Los métodos cromatográficos fueron diseñados para dar un cromatograma resuelto por completo, un pico coeluido y una situación intermediaria con un cromatograma resuelto parcialmente. Los datos fueron registrados en una matriz de tres dimensiones con las siguientes direcciones: (muestras medidas) x (proporción m/z) x (tiempo de retención). Por "colapsar" los ejes X e Y del tiempo de retención cromatográfica y los fragmentos m/z, respectivamente, se obtuvieron dos matrices que representan los espectros de masa regular y el cromatograma de iones totales, respectivamente. Estos enfoques sueltan la información traída por la tercera dimensión y el despliegue por lo que la matriz original 3D y la concatenación de las TIC y el espectro de masa media se han tenido en consideración como una forma de preservar la información adicional de la tercera dimensión en una matriz de dos dimensiones.
Los datos fueron tratados mediante la alineación de picos, con una media de centrado y la normalización por la altura máxima y el área del pico, los instrumentos de pre-procesamiento que también fueron evaluados por sus logros.
Para el análisis de datos de dos vías fueron utilizados el PCA, PLS-DA y fuzzyARTMAP. La agrupación de PCA y PARAFAC fueron evaluados por la relación intervariedad - intravariedad, mientras que los resultados mediante fuzzy ARTMAP fueron dados como el éxito de la las tasas de clasificación en porcentajes.
Cuando PCA y PARAFAC se utilizaron, como era de esperar, el método de cromatografía resuelto (método 1) dio los mejores resultados globales, donde los algoritmos 2D funcionan mejor, mientras que en un caso más complicado (picos más coeluidos del método 3) pierden eficacia frente a métodos 3D.
En el caso de PLS-DA y n-PLS, aunque los resultados no son tan concluyentes como los resultados del PCA y PARAFAC, tratándose de las diferencias mínimas, el modelo de vías múltiples PLS-DA ofrece un porcentaje de éxito en la predicción de ambos conjuntos de datos. También se recomienda el n-PLS en vez de utilizar datos desplegados y concatenados, ya que construye un modelo más parsimonioso.
Para el análisis fuzzyARTMAP, la estrategia de votación empleada ha demostrado que al usar los espectros de masa media y la información del cromatograma de iones totales juntos se obtienen resultados más consistentes.
En el segundo conjunto de datos se aborda el problema de la adulteración del aceite de oliva extra virgen con aceite de avellana, que debido a las similitudes entre los dos aceites es una de las más difíciles de detectar. Cuatro aceites extra virgen de oliva y dos aceites de avellana se midieron puros y en mezclas de 30%, 10%, 5% y 2% con los mismos objetivos mostrando que la adición de la extra dimensión mejora los resultados. Se han hechos cinco repeticiones para cada preparación, dando un total de 190 muestras: 4 aceites puros de oliva, 2 aceites puros de avellana y 32 adulteraciones de aceite de avellana en aceite de oliva, dando un total de 38 clases. Dos métodos cromatográficos fueron utilizados. El primero estaba dirigido a una completa separación de los componentes del aceite de oliva y empleó una separación con temperatura programable, mientras que el objetivo del segundo método fue un pico coeluido, por lo tanto fue contratada una temperatura constante de separación. Los datos fueron analizados por medio de la PCA, PARAFAC, PLS-DA y PLS-n.
Como en el conjunto "artificial" de datos, el PCA y PARAFAC se analizaron por medio de la capacidad de clusterización, que mostró que los mejores resultados se obtienen con los datos desplegados seguido por los datos 3D tratados con el PARAFAC.
Desde el punto de vista de optimización de la columna, los logros obtenidos por la columna corta está por debajo del enfoque de la columna larga, pero este caso demuestra una vez más que la adición de los incrementos de tercera dimensión mejoran la nariz electrónica basada en MS.
Para el PLS-DA y n-PLS se evaluaron las tasas de éxito comparativamente, tanto para las corridas cromatográficas largas como para las cortas. Mientras que para la columna larga el mejor rendimiento es para los datos del cromatograma de iones totales (TIC), la columna corta muestra mejor rendimiento para los datos concatenados de los espectros de masa media y TIC. Además, la predicción de las tasas de éxito son las mismas para los datos TIC de columna larga como para los datos concatenados de la columna corta. Este caso es muy interesante porque demuestra que el enfoque PLS de la tercera dimensión mejora los resultados y, por otra parte, mediante el uso de la columna corta el tiempo de análisis se acorta considerablemente.
Se esperan ciertos logros de la nariz electrónica. Por el momento, ninguno de esos enfoques se acercó lo suficiente para producir una respuesta positiva en los mercados. Los sensores de estado sólido tienen inconvenientes casi imposibles de superar. La nariz electrónica basada en espectrometría de masas tiene una falta de portabilidad y a veces sus logros son insuficientes, y el aparato del cromatógrafo de gases-espectrómetro de masas sufre problemas de portabilidad igual que espectrómetro de masas y toma mucho tiempo. El desarrollo de potentes algoritmos matemáticos durante los últimos años, junto con los avances en la miniaturización, tanto para MS y GC y mostrar cromatografía rápida cierta esperanza de una nariz electrónica mucho mejor.
A través de este trabajo podemos afirmar que la adición del tiempo de retención cromatográfica como una dimensión extra aporta una ventaja sobre las actuales tecnologías de la nariz electrónica. Mientras que para los cromatogramas totalmente resueltos no se logran mejoras o la ganancia es mínima, sobre todo en la predicción, para una columna corta la información adicional mejora los resultados, en algunos casos, hacerlos tan bien como cuando una larga columna se utiliza. Esto es muy importante ya que las mediciones en un cromatógrafo de gases - espectrometro de masas se pueden optimizar para tramos muy cortos, una característica muy importante para una nariz electrónica. Esto permitiría el diseño de un instrumento de mayor rendimiento, adecuado para el control de calidad en líneas de productos.
Konečný, Martin. "Návrh na vylepšení komunikační infrastruktůry gymnázia". Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2015. http://www.nusl.cz/ntk/nusl-224835.
Testo completoCrégheur, Eric. "Édition critique, traduction et introduction des « deux Livres de Iéou » (MS Bruce 96), avec des notes philologiques et textuelles". Thesis, Université Laval, 2013. http://www.theses.ulaval.ca/2013/29956/29956.pdf.
Testo completoThe subject of this thesis is the « two Books of Jeu », a Christian Gnostic treatise preserved in Coptic, generally dated from the fourth century C. E., and found in the Bruce Codex (MS Bruce 96). The Books of Jeu depicts a postresurrectional dialogue between Jesus and his disciples, in which Jesus reveals the configuration of the heavenly spheres, composed of eons and treasuries, and gives to the souls the means to cross them. Once they have passed through all these places and overcome all the obstacles posed by the archons that dwell there, the souls reach the highest sphere, where they can contemplate the unapproachable God and give glory to him. These revelations of Jesus are accompanied by several diagrams and illustrations, which represent the treasuries and the seals with which the souls must seal themselves. Acquired in the eighteenth century by the Scottish explorer and geographer James Bruce, the Books of Jeu is one of the oldest known direct sources of Gnosticism. Paradoxically, it is now among the least well known and disregarded texts of the Gnostic literature. To address this problem, our project has several objectives. It is primarily aimed at producing a new critical edition of the Coptic text of the « two Books of Jeu », a new French translation, and a philological, doctrinal, and historical introduction of the text. The edition and translation are followed by mainly philological and textual notes, which discuss the establishment of the text, the language and, the choices of our translation. This doctoral project distinguishes itself by its interest in both the external (the manuscript), and internal (the text) aspects of the Books of Jeu.
Crégheur, Éric. "Édition critique, traduction et introduction des « deux Livres de Iéou » (MS Bruce 96), avec des notes philologiques et textuelles". Doctoral thesis, Université Laval, 2013. http://hdl.handle.net/20.500.11794/24860.
Testo completoCette thèse a pour sujet les « deux Livres de Iéou », un traité chrétien gnostique conservé en copte, daté généralement du quatrième siècle de notre ère et préservé dans le codex Bruce (MS Bruce 96). Les Livres de Iéou mettent en scène un dialogue postrésurrectionnel entre Jésus et ses disciples, au cours duquel Jésus révèle la configuration des sphères célestes, composées d’éons et de trésors, et donne les moyens nécessaires pour que les âmes puissent les traverser. Une fois qu’elles ont traversé tous les lieux et surmonté toutes les embûches posées par les archontes qui les habitent, les âmes parviennent au lieu supérieur où elles peuvent contempler le Dieu inaccessible et lui rendre gloire. Ces révélations de Jésus sont accompagnées par plusieurs diagrammes et dessins, qui illustrent les trésors et les sceaux dont les âmes doivent se marquer. Acquis au dix-huitième siècle par l’explorateur et géographe écossais James Bruce, les Livres de Iéou sont une des plus anciennes sources directes du gnosticisme connues des chercheurs. Paradoxalement, ils figurent aujourd’hui parmi les textes les moins connus de la littérature gnostique. Pour répondre à ce problème, notre projet poursuit plusieurs objectifs. Il vise d’abord à produire une nouvelle édition critique du texte copte des « deux Livres de Iéou », une nouvelle traduction française et une introduction philologique, doctrinale et historique au texte. L’édition et la traduction sont enfin suivies de notes essentiellement philologiques et textuelles, qui discutent de l’établissement du texte, de la langue et des choix de notre traduction. Ce projet a comme particularité de s’intéresser à toutes les facettes, tant externes (le manuscrit, le contenant) qu’internes (les textes, le contenu), des Livres de Iéou.
The subject of this thesis is the « two Books of Jeu », a Christian Gnostic treatise preserved in Coptic, generally dated from the fourth century C. E., and found in the Bruce Codex (MS Bruce 96). The Books of Jeu depicts a postresurrectional dialogue between Jesus and his disciples, in which Jesus reveals the configuration of the heavenly spheres, composed of eons and treasuries, and gives to the souls the means to cross them. Once they have passed through all these places and overcome all the obstacles posed by the archons that dwell there, the souls reach the highest sphere, where they can contemplate the unapproachable God and give glory to him. These revelations of Jesus are accompanied by several diagrams and illustrations, which represent the treasuries and the seals with which the souls must seal themselves. Acquired in the eighteenth century by the Scottish explorer and geographer James Bruce, the Books of Jeu is one of the oldest known direct sources of Gnosticism. Paradoxically, it is now among the least well known and disregarded texts of the Gnostic literature. To address this problem, our project has several objectives. It is primarily aimed at producing a new critical edition of the Coptic text of the « two Books of Jeu », a new French translation, and a philological, doctrinal, and historical introduction of the text. The edition and translation are followed by mainly philological and textual notes, which discuss the establishment of the text, the language and, the choices of our translation. This doctoral project distinguishes itself by its interest in both the external (the manuscript), and internal (the text) aspects of the Books of Jeu.
Xiong, Li. "Correlation of analyses of odor profiles of HDPE films coated with different adhesives using electronic nose, sensory evaluation, and GC-MS". Diss., Connect to online resource - MSU authorized users, 2006.
Cerca il testo completoMonteau, Elodie. "Edition critique d'une révision du XVème siècle du recueil hagiographique moyen-anglais du "Festial" de John Mirk, conservé dans les manuscrits London British Library Harley 2247, Royal 18 B xxv & Trinity College Dublin 428, avec notes et glossaire". Poitiers, 1998. http://www.theses.fr/1998POIT5017.
Testo completoLainé, Ariane. "Cambridge University Library MS Gg. 6. 16 : édition critique et étude du contenu d'un outil de prédication moyen anglais, accompagnées de notes et d'un glossaire". Poitiers, 2000. http://www.theses.fr/2000POIT5014.
Testo completoDennery, Vaisman Anna. "La musique liturgique en l'abbaye de Saint Evroult d'après le Tropaire-prosaire ms. Paris, B. N. Lat. 10508". Paris 4, 1987. http://www.theses.fr/1987PA040201.
Testo completoThe manuscript listed as lat. 10508 in the Paris Bibliotheque Nationale, is made up of two different works bound together in one volume : 1) a cantatorium troper-proser, written for the use of saint Évroult abbey, in Normandy, dating from the early twelfth century, and 2) a musical treatise, from the same abbey, but very probably written at one of the foundations of saint Évroult in Italy, at about the same time. The historical and codicological survey of the manuscript is followed by an introduction to the proper of saint Évroult, which attests the presence of a few ancient liturgical forms that are gradually dying out. It enables us to observe uses peculiar to Normandy, particularly, concerning the introits. The following section is devoted to the genesis, development, and appearance in Normandy, and especially in abbey, of the tropes of ordinary and of sequentias. Analysis of their prosody shows that the Kírie eléison are not the result of laying a text under already existing melismas, as in the case with the sequentias. Rather they are a form of chant in which text and music were composed at the same time. The troper-sequentiary, of undoubted Norman origin, nevertheless contains chants from various other sources, for the works of the composers and poets of the North West make up only about one - third of saint Évroult repertory. The musical notations used in the manuscript run the gamut from neumes in campo aperto to guidonian notation, from alphabetical notation to the dasian. Additions show the evolution of notation on stave. A report on the interpretation, meaning, and liturgical use of the tropes and sequentias brings the survey to a close. It might just as well have been entitled: "musical and liturgical life at the saint Évroult abbey"
Kelly, Molly Kathleen. "Effect of Foliar Nitrogen and Sulfur Applications on Aroma Profile of Vitis vinifera L. cv. Petit Manseng using Modified Quantitative Descriptive Analysis, SPME GC-MS and Electronic Nose Technology". Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/49536.
Testo completoPh. D.
Vera, Carrasco Luciano. "Sensory quality control of alcoholic beverages using fast chemical sensors". Doctoral thesis, Universitat Rovira i Virgili, 2010. http://hdl.handle.net/10803/9061.
Testo completoEn la presente tesis Doctoral, han sido aplicados dos sensores artificiales para el análisis de
bebidas alcohólicas: la nariz electrónica basada en la espectrometría de masas (MS) y la lengua
electrónica basada en la espectroscopía infrarroja con transformada de Fourier (FTIR). El
propósito fue desarrollar nuevas estrategias para analizar la autenticidad de estos productos,
desde un punto de vista sensorial, por medio de técnicas las espectrales antes mencionadas.
Adicionalmente, ha sido utilizado un espectrofotómetro UV-visible como ojo electrónico. El
trabajo presentado pretende ser un avance significativo hacia el desarrollo de un catador
electrónico mediante la fusión de los tres sensores químicos: nariz electrónica, lengua
electrónica y ojo electrónico.
Sensory quality control of alcoholic beverages using fast chemical sensors
In the present Doctoral Thesis, two chemical artificial sensors are applied to the analysis of
alcoholic beverages: the Mass Spectrometry (MS)-based electronic-noses and Fourier
transform infrared (FTIR)-based electronic-tongue. The aim was developing new strategies to
test the authenticity of these products, from a sensory point of view, by means of the spectral
techniques above mentioned. Additionally, has been used an UV-visible spectrophotometer as
electronic eye. The work presented wants to be a significant advance towards the development
of an electronic taster through the fusion of three chemical sensors: electronic nose, electronic
tongue and electronic eye.
Ježek, Jan. "Statistický modul k pracovní databázi TIVOLE". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217191.
Testo completoPiQUILLOUD, IMBODEN Lise. "Apport de la physiologie dans l’optimisation de l’assistance ventilatoire : l’exploration de la commande respiratoire Information conveyed by electrical diaphragmatic activity during unstressed, stressed and assisted spontaneous breathing: a physiological study A diaphragmatic electrical activity-based optimization strategy during pressure support ventilation improves synchronization but does not impact work of breathing Accuracy of P0.1 measurements performed by ICU ventilators: a bench study". Thesis, Angers, 2019. http://www.theses.fr/2019ANGE0042.
Testo completoThe brainstem respiratory centers are in charge of breathing regulation. Their output is transmitted to the inspiratory muscles. Respiratory drive monitoring can be performed using the electrical activity of the diaphragm (Eadi) or the measurement of the occlusion pressure at 100 ms (P0.1). Monitoring these parameters should allow improving the delivered ventilator assist. Few data regarding the normal values of Eadi and P0.1 and their variations in non-physiological situations are available. The question of the reliability of the bedside measurements also remains opened.This thesis project aimed at increasing our knowledge on Eadi and P0.1 measurements. The studies performed allowed 1. better characterizing Eadi and P0.1 normal values in physiological and non-physiological situations. 2. demonstrating that Eadi maximal value well reflects inspiratory drive intensity, 3. demonstrating that Eadi monitoring provides additional information compared to respiratory profile and inspiratory effort monitoring, 4. demonstrating that Eadi and P0.1 are well correlated, 5. demonstrating that Eadi can be used to improve the ventilator settings during pressure support and that this strategy allows improving patient-ventilator synchrony. 6. showing that the P0.1 variations are well reflected by the P0.1 measured by the ventilators, 7. demonstrating that overall the P0.1 measured by the ventilators underestimate the reference P0.1. Additional studies in more patients and studies designed to assess the impact on patient’s outcome of using Eadi and P0.1 monitoring should be perform before recommaending these monitorings as a standard procedure in ventilated patients
SURDEL, ALAIN-JULIEN. "La vie de monseigneur sainct didier martir et evesque de lengres de guillaume flamang (1482). Tome 1 : edition du texte avec notes et glossaire d'apres le ms. no 159 de la bibliotheque municipale de chaumont (52). tome 2: etudes linguistique, historique et litteraire". Université Marc Bloch (Strasbourg) (1971-2008), 1997. http://www.theses.fr/1997STR20001.
Testo completoThis is a reedition of a hagiographical mystery (10495 verses) composed by guillaume flamang, a langres's cathedral canon, c. 1482. A foreword deals with the former edition by carnandet (1855) and describes the aims of the present one. We begin with a description of the ms. No 159 of the bibliotheque municipale in chaumont (eastern france) which transmitted the mystery. The edition of the text is preceded by a detailed synopsis and followed by the usual notes, glossary (100 pages) and indices. The second volume is dedicated to linguistical, historical and literary ananlysis. After a detailed bibliography, it ends with the preedition of five religious poems by guillaume flamang
Mohamadian, Wrya. "DILATOMETRIC EVALUATION OF SOME CRITICAL PHYSICAL PROPERTIES OF OT75 AND OT101 STEEL GRADES". Thesis, Luleå tekniska universitet, Institutionen för teknikvetenskap och matematik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-86758.
Testo completoHarengel, Peter. "Three Tales of Dominant Technological Artifacts : Tracing the Paths from Success to Domination of Software Applications with the Help of Latour's Actor-Network-Theory and Bourdieu's Capital Theory". Thesis, Blekinge Tekniska Högskola, Sektionen för datavetenskap och kommunikation, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-5265.
Testo completoLéal, Françoise. "Etude de la production et de l'émanation de composés volatils malodorants sur textile à usage sportif". Thesis, Vandoeuvre-les-Nancy, INPL, 2011. http://www.theses.fr/2011INPL070N/document.
Testo completoFresh human sweat is odorless. Odoriferous volatile compounds are produced by the metabolism of bacteria living on the skin, generating strong malodor. Sweaty body odors do also appear on clothes during use, and especially on synthetic fabrics. The aim of this document is to improve understanding of odor emission by investigating subject effect, microbiota effect and fabric effect on the emission of odoriferous volatile compounds.Odors of perspiration are hereby globally approached with a wide use of methods and experimental devices, for microbial flora study as well as for odoriferous volatile compounds emission study.First, microflora enumeration has been simultaneously processed on the skin and on the fabric after exercise for 15 subjects. This experiment allowed an evaluation of the average bacterial transfer yield during physical activity and the beginning of the investigation of its effect on odor emission.A molecular biology methodology has then been developed in order to refine these results. Monitoring of qualitative composition of the microbiota has been performed to study the stability of the armpit’s ecosystem on a subject during 3 months. Specific microbial transfer from subject’s skin to clothe has been performed for 4 textile fabrics (including cotton and PET). This leaded to characterize the effect of specific bacterial transfer on odor emission from fabric.The last chapter is dedicated to the study of the emission of odoriferous volatile compounds over time using olfactory measurements and electronic nose for 8 selected fabrics. Principal component analysis targeted 9 chemical compounds that have been selected as malodorous behavior indicators for a given fabric. Those 9 compounds could be used for setting up a fitted physicochemical method of malodor.To conclude, this study helped to understand the effect of 3 factors in odor perception from a fabric after sport : subject, microbial flora and fabric. Perspectives have been charted on contact microbial contamination, but also on odor, and especially on desorption of odoriferous volatile molecules from a textile or knitted matrix. The solutions that could be used to limit malodorous emission from fabrics have also been discussed
Han, I.-Fang, e 韓宜芳. "Identification of Odor Profile of Clam Water Extract by Electronic Nose and GC/MS". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/93081162210511075133.
Testo completo國立臺灣海洋大學
食品科學系
99
Freshwater clam (Corbicula fluminea) is a major cultivated bivalvia in Taiwan. In recent years, it has been used in dietary supplements. The odor of freshwater clam extracts due to processing may smell undesirable to consumer. The purpose of this study was to improve the odor by following the extraction process measuring VBN (volatile basic nitrogen), pH and Brix as indicators of quality of the clam extracts. Electronic nose (E-nose) was used to establish the odor fingerprint, GC-sniffing and GC-MS were used to evaluate and identify the odorous compounds of clam extract. The pH of the clam extracts was 9.2-8.6, it decreased during the batch heating process. The manufacturer-made clam extract had higher pH than the Lab-made extracts. VBN and Brix increased and the quantity of volatiles also increased during batch heating. E-nose sensors PA/2, T70/2, T30/1 showed significantly different plot in the odor fingerprint of clam extracts while sensors LY/LG, P40/1, P10/2, P10/1 did not show any difference. The principal component analysis (PCA) of the volatiles from different batch of clam extracts differed by 99.35%. The volatiles could be divided into heat-generated, heat-decomposed and heat-stable compounds based on GC-sniffing and GC/MS analysis of the extracts from heat process. Volatile aldehydes and alcohols were higher than other types of volatile compounds present in the clam extracts. 2-Pentanal (R.I. < 800, Almond, pungent odor), 4-heptenal (R.I. = 904, biscuit-like odor), benzaldehyde (R.I. = 964, almond, burnt sugar odor), nonanal (R.I. = 1107, fatty, citrus odor), 2-pentenol (R.I. < 800, green, plastic, rubber odor), 2-octanol (R.I. = 985, orange peel-like odor), 2,5-methylpyrazine (R.I. = 915, roasted nut, roasted beef odor) were present in the commercial products and lab-made clam extracts.
(8780765), Charles R. Bupp. "A nanoHILIC-MS Platform for Separation and Characterization of Glycoproteins". Thesis, 2020.
Cerca il testo completoSiddhu, Silvi. "Sensory analysis of refined and whole wheat breads made from red and white wheat using electronic nose and gas chromotography-mass spectrometry". 2010. http://hdl.handle.net/1993/3934.
Testo completo(5930282), Dalton T. Snyder. "One- and Two-dimensional Mass Spectrometry in a Linear Quadrupole Ion Trap". Thesis, 2019.
Cerca il testo completo(7013258), Tse-Hong Chen. "Polymer-Shell Bonded Phase for Improving Online LC-MS Analysis of Intact Proteins, mAbs, and ADCs". Thesis, 2019.
Cerca il testo completoLC-MS of protein drugs requires new ideas in bonded phase design rather than adapting bonded phases from the realm of small-molecule drugs. The polymer-shell bonded phase is designed to interact with larger molecules and to shield proteins from the silica substrate. The particles consist of a core of solid silica and a shell of dense polymer brush. The polymer layer is thick enough to protect the protein from interactions with silanols to reduce peak tailing. The polymer contains multiple functional groups that introduce more selectivity. This design gives unprecedented LC resolution and MS sensitivity. Our group has developed polymer shell bonded phases for hydrophobic interaction chromatography (HIC-MS) of antibody-drug conjugates (ADCs), hydrophilic interaction liquid chromatography (HILIC-MS) of glycoproteins, and reversed-phase liquid chromatography (RPLC-MS) of monoclonal antibodies. Since HIC is not in-line compatible with MS due to the high salt levels, it is laborious to identify the constituents of HIC peaks. An MS-compatible alternative to HIC is reported here: native reversed phase liquid chromatography (nRPLC). This employs a mobile phase 50 mM ammonium acetate for high sensitivity in MS, and elution with a gradient of water/isopropanol. The nRPLC-MS data show that all ADC species, ranging from drug-to-antibody ratios of 1 to 8, remained intact and native on the column. As we adapt this concept to intact proteins, we find that lysozyme and α-chymotrypsinogen A are both eluted in their native conformations. We also use the polymer-shell concept to resolve IgG1 free thiol variants by RPLC-MS with 0.5% formic acid. Since there are always other variants besides the intended ones, the need for high MS sensitivity is desired to distinguish subtle mass change between disulfide bond and free thiols. Overall, MS sensitivity increases 10X relative while all of the thiol variants are well resolved by the polymethylmethacrylate bonded phase.
Masoodi, Mojgan, Anna Nicolaou, Karl Gledhill, L. E. Rhodes, Desmond J. Tobin e Anthony J. Thody. "Prostaglandin D2 production in FM55 melanoma cells is regulated by ¿-melanocyte stimulating hormone and is not related to melanin production". 2010. http://hdl.handle.net/10454/4581.
Testo completoThis study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX-1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independently. ¿-Melanocyte stimulating hormone (¿-MSH), which had no effect on melanin production in FM55 cells, stimulated PGD2 production in these cells without affecting PGE2. While cAMP pathways may be involved in regulating PGD2 production, our results suggest that ¿-MSH acts independently of cAMP, possibly by regulating the activity of lipocalin-type PGD synthase. This ¿-MSH-mediated effect may be associated with its role as an immune modulator.
The Wellcome Trust
(6449489), Feifei Zhao. "Development and Application of Theta Tips as a Novel nESI-MS Ion Source and Protein Identification Using Limited Trypsin Digestion and Mass Spectrometry". 2019.
Cerca il testo completo(9137873), Zhuoer Xie. "Accelerating the Throughput of Mass Spectrometry Analysis by Advanced Workflow and Instrumentation". Thesis, 2020.
Cerca il testo completoThe exploratory profiling and quantitative bioassays of lipids, small metabolites, and peptides have always been challenging tasks. The most popular instrument platform deployed to solve these problems is chromatography coupled with mass spectrometry. However, it requires large amounts of instrument time, intensive labor, and frequent maintenance, and usually produces results with bias. Thus, the pace of exploratory research is one of poor efficacy and low throughput. The work in this dissertation provides two practical tactics to address these problems. The first solution is multiple reaction monitoring profiling (MRM-profiling), a new concept intended to shift the exploratory research from current identification-centered metabolomics and lipidomics to functional group screening by taking advantage of precursor ion scan and product ion scan. It is also demonstrated that MRM-profiling is capable of quantifying the relative amount of lipids within the same subclass. Besides, an application of the whole workflow to investigate the strain-level differences of bacteria is described. The results have zeroed in on several potential lipid biomarkers and corresponding MRM transitions. The second strategy is aimed to increase the throughput of targeted bioassays by conducting induced nanoelectrospray ionization (nESI) in batch mode. A novel prototype instrument named "Dip-and-Go" system is presented. Characterization of its ability to carry out reaction screening and bioassays exhibits the versatility of the system. The distinct electrophoretic cleaning mechanism contributes to the removal of salt during ionization, which assures the accuracy of measurement.
(11178123), Chau Bao Nguyen. "Paper Spray - Mass Spectrometry: Investigation of Sampling Devices for Illicit Drug Detection and Quantification". Thesis, 2021.
Cerca il testo completo(8771429), Ashley S. Dale. "3D OBJECT DETECTION USING VIRTUAL ENVIRONMENT ASSISTED DEEP NETWORK TRAINING". Thesis, 2021.
Cerca il testo completoAn RGBZ synthetic dataset consisting of five object classes in a variety of virtual environments and orientations was combined with a small sample of real-world image data and used to train the Mask R-CNN (MR-CNN) architecture in a variety of configurations. When the MR-CNN architecture was initialized with MS COCO weights and the heads were trained with a mix of synthetic data and real world data, F1 scores improved in four of the five classes: The average maximum F1-score of all classes and all epochs for the networks trained with synthetic data is F1∗ = 0.91, compared to F1 = 0.89 for the networks trained exclusively with real data, and the standard deviation of the maximum mean F1-score for synthetically trained networks is σ∗ F1 = 0.015, compared to σF 1 = 0.020 for the networks trained exclusively with real data. Various backgrounds in synthetic data were shown to have negligible impact on F1 scores, opening the door to abstract backgrounds and minimizing the need for intensive synthetic data fabrication. When the MR-CNN architecture was initialized with MS COCO weights and depth data was included in the training data, the net- work was shown to rely heavily on the initial convolutional input to feed features into the network, the image depth channel was shown to influence mask generation, and the image color channels were shown to influence object classification. A set of latent variables for a subset of the synthetic datatset was generated with a Variational Autoencoder then analyzed using Principle Component Analysis and Uniform Manifold Projection and Approximation (UMAP). The UMAP analysis showed no meaningful distinction between real-world and synthetic data, and a small bias towards clustering based on image background.
GORLA, Sandra. "Metamorfosi e magia nel Roman de Renart. Traduzione e commento delle branches XXII e XXIII". Doctoral thesis, 2018. http://hdl.handle.net/11393/251268.
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