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1
Che, Lida, Kai Wang, Zhanfang Wu e Xiangyang Li. "The Combination of X-ray Ct and Multi-particle Finite Element Method for Powder Compaction". Journal of Physics: Conference Series 2913, n. 1 (1 dicembre 2024): 012015. https://doi.org/10.1088/1742-6596/2913/1/012015.
Testo completoAbstract (sommario):
Abstract The macroscopic mechanical properties of granular materials are closely related to their microscopic properties, and studying the compression problem of powder is helpful for establishing a constitutive law of powder compaction process. This study utilized X-ray CT technology to investigate the 3D numerical analysis model of loose particle stacking and compaction based on MPFEM, and investigated the mechanical behavior of powder under compression. The results of MPFEM were experimentally verified through powder uniaxial compression experiments, and the results showed that the calculated results of MPFEM were in good agreement with the experimental results. The method of X-ray CT can effectively capture the geometric characteristics of powder particles, and the MPFEM can obtain the true characteristics of plastic deformation of powder bodies, which is an important means of developing powder compaction constitutive models.
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Lee, Kyung-Hun, Jung-Min Lee e Byung-Min Kim. "Particle Behavior and Deformation During Compaction of Al Powder Using MPFEM". Transactions of the Korean Society of Mechanical Engineers A 34, n. 4 (1 aprile 2010): 383–90. http://dx.doi.org/10.3795/ksme-a.2010.34.4.383.
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Zhang, Wei, Chuanniu Yuan, Weijian Xiao, Xu Gong, Bozhan Hai, Rongxin Chen e Jian Zhou. "MPFEM investigation on densification and mechanical structures during ferrous powder compaction". Advanced Powder Technology 35, n. 12 (dicembre 2024): 104700. http://dx.doi.org/10.1016/j.apt.2024.104700.
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Han, Peng, Xizhong An, Yuxi Zhang, Fen Huang, Tingxuan Yang, Haitao Fu, Xiaohong Yang e Zongshu Zou. "Particulate scale MPFEM modeling on compaction of Fe and Al composite powders". Powder Technology 314 (giugno 2017): 69–77. http://dx.doi.org/10.1016/j.powtec.2016.11.021.
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Xu, Lei, Yasong Wang, Changyun Li, Guoliang Ji e Guofa Mi. "MPFEM simulation on hot-pressing densification process of SiC particle/6061Al composite powders". Journal of Physics and Chemistry of Solids 159 (dicembre 2021): 110259. http://dx.doi.org/10.1016/j.jpcs.2021.110259.
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Jia, Qian, Xizhong An, Haiyang Zhao, Haitao Fu, Hao Zhang e Xiaohong Yang. "Compaction and solid-state sintering of tungsten powders: MPFEM simulation and experimental verification". Journal of Alloys and Compounds 750 (giugno 2018): 341–49. http://dx.doi.org/10.1016/j.jallcom.2018.03.387.
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Demirtas, Ahmet, e Gerard R. Klinzing. "Understanding die compaction of hollow spheres using the multi-particle finite element method (MPFEM)". Powder Technology 391 (ottobre 2021): 34–45. http://dx.doi.org/10.1016/j.powtec.2021.06.004.
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Zou, Yi, Xizhong An, Qian Jia, Ruiping Zou e Aibing Yu. "Three-dimensional MPFEM modelling on isostatic pressing and solid phase sintering of tungsten powders". Powder Technology 354 (settembre 2019): 854–66. http://dx.doi.org/10.1016/j.powtec.2019.07.013.
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Han, Peng, Xizhong An, Defeng Wang, Haitao Fu, Xiaohong Yang, Hao Zhang e Zongshu Zou. "MPFEM simulation of compaction densification behavior of Fe-Al composite powders with different size ratios". Journal of Alloys and Compounds 741 (aprile 2018): 473–81. http://dx.doi.org/10.1016/j.jallcom.2018.01.198.
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Güner, Faruk. "Numerical Investigation of AISI 4140 Powder High Relative Density Compaction In Terms of Compaction Velocity". Mechanics 26, n. 1 (12 febbraio 2020): 5–11. http://dx.doi.org/10.5755/j01.mech.26.1.22862.
Testo completoAbstract (sommario):
In this study high relative density compaction of AISI 4140 steel powder compaction numerically investigated via different compaction velocities using Multi Particle Finite Element Method (MPFEM). 2D Analyses performed by three different particle geometry; 25µm, 35µm and 45µm in radius. Particle size effect also investigated via high relative density and compaction velocity. von Mises Power law evaluated for AISI 4140 steel powder and utilized to analysis. Results were plotted both in visually and graphically in aim to show effect of relative density, particle size, contact interactions and compaction velocity. The stress distribution through the height of die revealed out. A four-fold increase in compaction velocity increase the Equivalent von Mises stress 2% where the stress value can reach up to 3 times the yield stress. Stress values along the punch to the bottom of the die show a parabolic tendency with compaction velocity increase.
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Kim, Jaemin, e Seonbong Lee. "Study on Compressibility According to Mixing Ratio and Milling Time of Fe-6.5wt.%Si". Materials 17, n. 8 (9 aprile 2024): 1723. http://dx.doi.org/10.3390/ma17081723.
Testo completoAbstract (sommario):
Recently, researchers have focused on improving motor performance and efficiency. To manufacture motors with performance and efficiency higher than those of motors manufactured through the additive process, compressibility verification through the parameter control of soft magnetic composites (SMCs) is essential. To this end, this study aims to select suitable powders for manufacturing high-performance, high-efficiency motors by exploring powder mixing ratios and milling times. Through physical property tests, the optimal mixing ratio is predicted using the Multi-Particle Finite Element Method (MPFEM) and powder compression molding analysis, and compressibility is predicted in view of the influence of a change in particle size as a function of the powder mixing ratio and milling time. In addition, based on the result of a comparative analysis of density through experiments and an analysis of internal defects through SEM, a 50:50 mixing ratio of hybrid atomizing and gas atomizing powders milled for 3 h provided the best compressibility. Therefore, the use of SMC cores fabricated using powder compression molding is expected to improve motor performance and efficiency.
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Wang, Defeng, Xizhong An, Peng Han, Haitao Fu, Xiaohong Yang e Qingchuan Zou. "Particulate Scale Numerical Investigation on the Compaction of TiC-316L Composite Powders". Mathematical Problems in Engineering 2020 (29 febbraio 2020): 1–13. http://dx.doi.org/10.1155/2020/5468076.
Testo completoAbstract (sommario):
This paper presents a numerical investigation on the 2D uniaxial die compaction of TiC-316L stainless steel (abbreviated by 316L) composite powders by the multiparticle finite element method (MPFEM). The effects of TiC-316L particle size ratios, TiC contents, and initial packing structures on the compaction process are systematically characterized and analyzed from macroscale and particulate scale. Numerical results show that different initial packing structures have significant impacts on the densification process of TiC-316L composite powders; a denser initial packing structure with the same composition can improve the compaction densification of TiC-316L composite powders. Smaller size ratio of 316L and TiC particles (R316L/RTiC = 1) will help achieve the green compact with higher relative density as the TiC content and compaction pressure are fixed. Meanwhile, increasing TiC content reduces the relative density of the green compact. In the dynamic compaction process, the void filling is mainly completed by particle rearrangement and plastic deformation of 316L particles. Furthermore, the contacted TiC particles will form the force chains impeding the densification process and cause the serious stress concentration within them. Increasing TiC content and R316L/RTiC can create larger stresses in the compact. The results provide valuable information for the formation of high-quality TiC-316L compacts in PM process.
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Li, Junnan, Peng Han, Yingshi Xu, Kun Liu, Guoxin Zhang e Peng Xu. "A Study of Compaction Densification Behavior of Composite Particles by Multiparticle Finite Element Method". Mathematical Problems in Engineering 2022 (10 febbraio 2022): 1–11. http://dx.doi.org/10.1155/2022/8580849.
Testo completoAbstract (sommario):
In this paper, 3D particulate scale modelling on the die compaction of DEM generated initial packings of both soft and hard particles was conducted by employing the multiparticle finite element method (MPFEM). The effects of initial packing structures as well as the compaction pressure on the macroscopic and microscopic properties of the whole powder mass and local structures were investigated. In addition, corresponding physical experiments were carried out for model validation. The results show that the compact obtained from the initial dense packing under vibration undergoes yielding stage earlier than that with natural initial packing (without vibration), and the relative density is much higher. Pores that are significantly smaller and with more uniform size and homogenous stress distribution are observed in the former case. Highest stress regions occur in most cases at a grain boundary with large curvature after deformation. Moreover, the high stress in the central part of both soft and hard particles during compaction is significantly reduced after pressure unloading, reaching a new force balance. In this case, the stress is concentrated mainly at the corners of the deformed particles, which creates the risk of cracking during subsequent sintering at either the contact region between particles or the corners. The numerical results are found to be in good agreement with those from physical experiments, confirming the robustness and reliability of the numerical model used in the simulations.
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Zhou, Jian, Chenyu Zhu, Wei Zhang, Wentao Ai, Xuejie Zhang e Kun Liu. "Experimental and 3D MPFEM simulation study on the green density of Ti–6Al–4V powder compact during uniaxial high velocity compaction". Journal of Alloys and Compounds 817 (marzo 2020): 153226. http://dx.doi.org/10.1016/j.jallcom.2019.153226.
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Zhou, Liwen, Peng Han, Kun Liu, Lianghua Feng e Guangqiang Liu. "Particulate Scale Multiparticle Finite Element Method Modeling on the 2D Compaction and Release of Copper Powder". Mathematical Problems in Engineering 2019 (16 novembre 2019): 1–10. http://dx.doi.org/10.1155/2019/5269302.
Testo completoAbstract (sommario):
Herein, two-dimensional (2D) single-action die compaction process of copper (Cu) powder was simulated by the multiparticle finite element method (MPFEM) at particulate scale. The initial packing structure, generated by the discrete element method (DEM), was used as an input for the FEM model, where the mesh division of each particle was discretized. The evolution of macro- and microscopic properties, such as relative density, stress distribution, particle deformation, void filling behavior, and force transmission, during compaction and pressure release processes have been systematically studied. The results revealed that the force is mainly concentrated on largely deformed regions of the particles during compaction and formed a contact force network, which hindered the densification process. In the compact, the shorter side of the large void edges rendered higher stress than the longer side. On the other hand, the stress distribution of small void edges remained uniform. After pressure release, large residual stress was observed at the contact area of the adjacent particles and the maximum stress was observed at the particles’ edges. Moreover, the residual stress did not proceed to the interior of the particles. Meanwhile, the stress of large void edges has been completely released but exhibited a nonuniform distribution. The smaller fraction of void filling resulted in a larger reduction of the released stress after pressure removal. Also, the particles closer to the upper die exhibited higher average equivalent von Mises stress inside the particles during compaction and pressure release processes.
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Giannis, Kostas, Arno Kwade, Jan Henrik Finke e Carsten Schilde. "The Effect of Particle Shape on the Compaction of Realistic Non-Spherical Particles—A Multi-Contact DEM Study". Pharmaceutics 15, n. 3 (10 marzo 2023): 909. http://dx.doi.org/10.3390/pharmaceutics15030909.
Testo completoAbstract (sommario):
The purpose of this study was to investigate the deformation behavior of non-spherical particles during high-load compaction using the multi-contact discrete element method (MC-DEM). To account for non-spherical particles, the bonded multi-sphere method (BMS), which incorporates intragranular bonds between particles, and the conventional multi-sphere (CMS), where overlaps between particles are allowed to form a rigid body, were used. Several test cases were performed to justify the conclusions of this study. The bonded multi-sphere method was first employed to study the compression of a single rubber sphere. This method’s ability to naturally handle large elastic deformations is demonstrated by its agreement with experimental data. This result was validated further through detailed finite element simulations (multiple particle finite element method (MPFEM)). Furthermore, the conventional multi-sphere (CMS) approach, in which overlaps between particles are allowed to form a rigid body, was used for the same objective, and revealed the limitations of this method in successfully capturing the compression behavior of a single rubber sphere. Finally, the uniaxial compaction of a microcrystalline cellulose-grade material, Avicel® PH 200 (FMC BioPolymer, Philadelphia, PA, USA), subjected to high confining conditions was studied using the BMS method. A series of simulation results was obtained with realistic non-spherical particles and compared with the experimental data. For a system composed of non-spherical particles, the multi-contact DEM showed very good agreement with experimental data.
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Oddone, Enrico, Jordy Bollon, Consuelo Rubina Nava, Giada Minelli, Marcello Imbriani, Dario Consonni, Alessandro Marinaccio, Corrado Magnani e Francesco Barone-Adesi. "Forecast of Malignant Peritoneal Mesothelioma Mortality in Italy up to 2040". International Journal of Environmental Research and Public Health 18, n. 1 (28 dicembre 2020): 160. http://dx.doi.org/10.3390/ijerph18010160.
Testo completoAbstract (sommario):
Despite their differences, pleural and peritoneal mesothelioma are frequently lumped together to describe epidemic curves and to forecast future mesothelioma trends. This study aims to describe the malignant peritoneal mesothelioma (MPeM) epidemic in Italy (1996–2016) and to forecast future trends up to 2040 in order to contribute to the assessment of MPeM future burden. All MPeM deaths in Italy from 1996–2016 were collected (as provided by the Italian National Statistical Institute (ISTAT)) in order to estimate MPeM mortality rates for each 3-year period from 1996 to 2016. Poisson age-period-cohort (APC) models were then used to forecast MPeM future trends. Between 2017 and 2040, 1333 MPeM deaths are expected. The number of MPeM deaths, as well as mortality rates, are expected to constantly decrease throughout the considered period. Based on considering the information from this study, it can be concluded that the MPeM epidemic has probably already reached its peak in Italy.
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Chapman, Lynne O., Michael J. Overman, Anneleis Willett, Mark Knafl, Szu-Chin Fu, Anais Malpica, Christopher Scally et al. "Comprehensive genomic profiling of malignant peritoneal mesothelioma (MPeM) reveals key genomic alterations (GAs) distinct from malignant pleural mesothelioma (MPM)." Journal of Clinical Oncology 39, n. 15_suppl (20 maggio 2021): 8557. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.8557.
Testo completoAbstract (sommario):
8557 Background: MPeM is a rare and aggressive cancer with very limited treatment options. Lack of dedicated research has impeded improvements in outcomes. Defining prevalent GAs is a critical unmet need for use of targeted therapies in these patients. Although MPeM is notably distinct from MPM vis-à-vis epidemiologic and clinical attributes, the genomic underpinings of these differences have yet to be established. We aimed at describing a comprehensive genomic profile (CGP) of MPeM in comparison to MPM. Methods: We performed a retrospective comparative analysis between 89 patients with MPeM and 241 patients with MPM (N = 330) who underwent CGP using CLIA certified next-generation sequencing assays. The cohort was generated using mesothelioma patients at MD Anderson Cancer Center (N = 223) and supplemented by additional mesothelioma patients (N = 107) from a publicly available database from Memorial Sloan Kettering Cancer Center, the MSK-IMPACT database. Essential clinicopathological variables were collected. Descriptive statistics, Fisher’s exact and Mann-Whitney tests were used for comparison. Kaplan-meier method and log rank tests were used for overall survival (OS) estimates. Results: MPeM cohort (vs. MPM) had more women (54% vs. 31%, P < 0.001) and younger age at diagnosis (56 vs. 69 years, P < 0.001). Histology was epithelioid, biphasic and sarcomatoid in 86%, 7% and 7% cases, a distribution similar to MPM cohort. At least 1 GA was found in 64 (72% vs. 82% in MPM, P = 0.044) of MPeM patients with a median of 1 (range 1 – 12) (vs. a median of 2, range 1 – 24, P < 0.001) GA per patient. A significantly lower proportion of MPeM patients had ≥ 3 mutations (14% vs. 26%, OR 2.1, P = 0.028) per patient. The most frequent mutations were present in the following genes: TP53 (24%), BAP1 (16%), NF2 (15%), MET (9%) and TRAF7, KIT and PIK3CA (each 6%). MPeM patients harbored more mutations in MET (9% vs. < 1%, P < 0.001) and TRAF7 (6% vs. < 1%, P = 0.02) but fewer mutations in BAP1 (16% vs. 32%, P = 0.003) and CDKN2B (0% vs. 5%, P = 0.041). The most common copy number variations (CNVs: amplifications or deletions) were seen in BAP1, MCL1, SETD2, WT1 (each 2%) and AURKA (1%) genes. Among genes with CNVs, MPeM had a lower rate of deletions in CDKN2A (1% vs. 6%, P = 0.040). Among more common GAs, only BAP1 mutations appeared to be associated with poor OS (45.7 vs. 127.1 months, HR 2.5, 95%CI: 0.6 – 10.1, P = 0.050) in patients with MPeM. Conclusions: In this large cohort with CGP, we identified potential molecular drivers in MPeM and demonstrated key genomic differences between MPeM and MPM. MPeM is frequently driven by GAs involved in cell cycle control, a potentially targetable pathway. Despite this insight from CGP, a large subset of patients do not have actionable GAs and for these patients, further collaborative trans-“omic” research efforts are needed to advance potential therapeutic options.
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Katiyar, Vatsala, Rohit Kumar, Ishaan Vohra e Adam Rojan. "Comparison of clinical characteristics and survival outcomes in patients with malignant peritoneal and pleural mesothelioma." Journal of Clinical Oncology 39, n. 3_suppl (20 gennaio 2021): 460. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.460.
Testo completoAbstract (sommario):
460 Background: Malignant peritoneal mesothelioma (MPeM) is an aggressive tumor strongly associated with asbestos exposure. We analyzed a large nationwide database to better understand the differences in the demographic and clinical patterns of MPeM and pleural mesothelioma (MPlM). Methods: The National Cancer Database (NCDB) 2010-15 was queried to identify all patients diagnosed with MpeM and MPlM. The demographic and clinical characteristics were compared using Pearson’s chi-square test. Kaplan-Meier method and associated log-rank test were used to compare the unadjusted overall survival of the two malignant mesothelioma (MM) sites. A multivariate Cox regression analysis was done to determine survival difference between the 2 groups. Results: Of the 8,668 patients included in the study, 1,081 (12.5%) had MPeM and 7,587 (87.5%) had MPlM. The MPeM cohort was younger (median age at diagnosis 61 vs 73 years), predominantly females (45.7% vs 23.5%), had a lower Charlson Deyo Comorbidity Score ( > = 1: 24.5% vs 32.1%), had higher percentage of uninsured patients (4% vs 2.2%), was less likely to be treated at a community or comprehensive community center (36.1% vs 47.3%) and had lower proportion of sarcomatous or biphasic histology (9.3% vs 22.4%) compared to MPlM cohort. The MPeM cohort was more likely to receive surgery (56.5% vs 28%) and chemotherapy (68.4% vs 54.5%) but less likely to receive radiation (0.8% vs 11%). The p-value was < 0.001 for all comparisons. The median OS was 19.7 and 9.7 months for patients with MPeM and MPlM, respectively (log-rank p value < 0.001). On multivariate Cox proportional hazards analysis, OS was significantly worse for MPlP compared to MPeP [HR adj: 1.19, 95% confidence interval (CI): 1.09-1.30 (p < 0.001)]. Conclusions: There is paucity of data about clinical characteristics and outcomes of MPeM. Much of our current knowledge about MPeM is extrapolated from MPlM. Our study suggests significant differences in prognostic factors and survival outcomes between the two sites.
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Segundo-Paredes, Jorge, Marcos Espinola-Sánchez, Claudia Saldaña-Diaz, Joyce Desposorio-Robles, Jacqueline Mejía-Veramendi, Augusto Elmer Racchumí Vela, Pedro Arango-Ochante e Carlos Gonzales-Medina. "Factores asociados al acceso de métodos de planificación familiar modernos en mujeres en edad fértil inmigrantes venezolanas en Perú. ENPOVE 2018". Revista Peruana de Investigación Materno Perinatal 9, n. 1 (14 aprile 2020): 59–68. http://dx.doi.org/10.33421/inmp.2020188.
Testo completoAbstract (sommario):
Objetivo. Estimar la prevalencia y determinar los factores asociados al acceso de métodos de planificación familiar modernos (MPFM) en mujeres en edad fértil inmigrantes venezolanas en Perú. Materiales y métodos. Estudio observacional, transversal y analítico de la Encuesta Dirigida a la Población Venezolana que Reside en el País (ENPOVE) 2018. Se calculó la proporción de mujeres en edad fértil inmigrantes venezolanas con acceso a MPFM. Se estimaron razones de prevalencia (RP) crudas y ajustadas (RPa) del acceso a MPFM, usando modelos lineales generalizados. Resultados. Se incluyeron 3378 mujeres en edad fértil inmigrantes venezolanas. El 78,45% no tuvo acceso a MMPF. Estar en la etapa de vida joven (RPa:1.07; IC:1.05-1.14), ser casada (RPa:1.09; IC:1.03-1.14), conviviente (RPc:1.11; IC:1.06-1.16), residir en la ciudad de Trujillo (RPa:1.21; IC:1.13-1.29) se asociaron a una mayor probabilidad de acceder de MPFM. Conclusiones. Tres de cada diez mujeres en edad fértil inmigrantes venezolanas en Perú tiene acceso a MPFM. Ser joven, casada, conviviente, y residir en la ciudad de Trujillo incrementa la probabilidad de acceder a MMPF inmigrantes venezolanas en el Perú. Los servicios de salud sexual y reproductiva deben estar priorizados a aquellas a ciudades y etapas de vida con mayores barreras en el acceso a MPFM.
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Steadman, Jessica A., e Travis E. Grotz. "Principles of Surgical Management of Peritoneal Mesothelioma". Journal of the National Comprehensive Cancer Network 21, n. 9 (settembre 2023): 981–86. http://dx.doi.org/10.6004/jnccn.2023.7055.
Testo completoAbstract (sommario):
Malignant peritoneal mesothelioma (MPeM) is a rare malignancy and represents 5% to 30% of malignant mesothelioma cases. The primary curative therapy for MPeM is radical cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), with the strongest predictor of long-term survival being complete cytoreduction. There is a paucity of high-quality evidence available to guide management in MPeM; however, NCCN Guidelines for the management of MPeM were updated this year. In well-selected patients, 5-year overall survival exceeds 65%, but achieving optimal results requires careful preoperative evaluation and expert surgical management. Preoperative patient selection includes histology review and staging with cross-sectional imaging. Ideal candidates for curative intent surgery are those with epithelioid MPeM, a low peritoneal cancer index, and a good performance status. Contraindications to curative intent surgery include the sarcomatoid MPeM, distant metastases, extensive nodal metastases, and extensive small bowel serosal or mesentery involvement not amenable to complete cytoreduction. Those with biphasic histology, bicavitary disease, and metastatic lymphadenopathy may be considered for surgery following response to neoadjuvant therapy. CRS involves resection of all peritoneal disease, the extent of which varies case by case. Key aspects involve careful evaluation of all peritoneal surfaces, complete parietal peritonectomy and omentectomy, and evaluating suspicious abdominal lymph node basins. Once maximum cytoreduction is achieved, HIPEC is performed using a platinum-based perfusate. Postoperative protocols are recommended to optimize recovery and mitigate HIPEC-specific complications, namely chemotherapy-mediated nephrotoxicity and bone marrow suppression.
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Nagata, Yusuke, Ryoichi Sawada, Atsuo Takashima, Hirokazu Shoji, Yoshitaka Honma, Satoru Iwasa, Katsushi Amano et al. "Efficacy and safety of pemetrexed plus cisplatin as first-line chemotherapy in advanced malignant peritoneal mesothelioma". Japanese Journal of Clinical Oncology 49, n. 11 (9 luglio 2019): 1004–8. http://dx.doi.org/10.1093/jjco/hyz104.
Testo completoAbstract (sommario):
Abstract Background Malignant peritoneal mesothelioma (MPeM) is a rare cancer for which no standard systemic chemotherapy has been established. While cisplatin plus pemetrexed, the standard treatment for malignant pleural mesothelioma (MPlM), is usually used for MPeM, its efficacy remains unclear. Methods We retrospectively reviewed the medical charts of MPeM patients who had received cisplatin plus pemetrexed as first-line chemotherapy between January 2001 and July 2016 at the National Cancer Center Hospital. Patients received cisplatin 75 mg/m2 and pemetrexed 500 mg/m2 on day1, repeated every 3 weeks until progressive disease, unacceptable toxicities or patient’s refusal to continue. Results A total of 29 MPeM patients received cisplatin plus pemetrexed. Median progression-free survival and overall survival were 7.1 months (95% CI: 4.8–9.3) and 15.4 months (95% CI: 9.5–21.2), respectively. Among 16 patients with measurable lesions, the response rate was 38%. Incidences of grade 3/4 leukopenia, neutropenia, anemia and thrombocytopenia were 21%, 17%, 14% and 3%, respectively. Non-hematological toxicities were mild, and there were no treatment-related deaths. Conclusions Cisplatin plus pemetrexed, showing consistent efficacy with MPlM, can be recommended as first-line treatment for unresectable MPeM patients.
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Liang, Yufei, Guoqi Zheng, Wenjie Yin, Hui Song, Chunying Li, Liang Tian e Dongliang Yang. "Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma". Gastroenterology Research and Practice 2019 (4 febbraio 2019): 1–9. http://dx.doi.org/10.1155/2019/7103915.
Testo completoAbstract (sommario):
Objective. The aim of our study was to investigate the expression of EGFR and PTEN in tissues and measure the serum platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) to evaluate the prognostic factors of patients with epithelioid malignant peritoneal mesothelioma (MPeM). Methods. 33 patients of pathologically diagnosed epithelioid MPeM tissues were analyzed using immunohistochemistry to detect EGFR and PTEN; the PLR and NLR were determined by using a routine blood test. We analyzed the relationships of these markers to age, sex, asbestos exposure, elevated platelet count, ascites, and clinical stage. Results. EGFR and PTEN expressions were positive in 22 (66.67%) and 7 (21.21%) epithelioid MPeM patients, respectively. However, these two markers as well as PLR and NLR were not significantly associated with age, sex, asbestos exposure, elevated platelet counts, ascites, and clinical stage (P>0.05). The correlation between EGFR and PTEN was negative (r=−0.577, P<0.001), but the correlation between NLR and PLR was positive (r=0.456, P=0.008). The median survival of all patients was 6 months. In univariate analysis, PTEN (P<0.001), PLR (P=0.014), and NLR (P=0.015) affected the overall survival. Multivariate analysis revealed that PTEN and PLR were validated as predictive for overall survival of epithelioid MPeM (HR=0.070, P=0.001, and HR=3.379, P=0.007, respectively). Conclusion. On the basis of these results, it is suggested that PTEN and PLR are risk factors for the prognosis of epithelioid MPeM, which may be targets for selective therapies and improve the outcomes of patients with epithelioid MPeM.
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Tanaka, Takaaki, Yosuke Miyamoto, Atsue Sakai e Nobukazu Fujimoto. "Nivolumab for malignant peritoneal mesothelioma". BMJ Case Reports 13, n. 11 (novembre 2020): e237721. http://dx.doi.org/10.1136/bcr-2020-237721.
Testo completoAbstract (sommario):
Malignant peritoneal mesothelioma (MPeM) is a highly malignant neoplasm of the peritoneum, which carries a poor prognosis. A 70-year-old man, who was employed in the shipbuilding industry and exposed to asbestos for 50 years, was found to have a low-density lesion in the peritoneum around the liver and spleen, associated with multiple mediastinal and parasternal lymphadenopathy. Laparoscopic exploration was performed, and biopsy specimen analysis led to a diagnosis of MPeM. Initial systemic chemotherapy comprising cisplatin and pemetrexed yielded a modest cytoreductive effect. However, 4 months later, the patient presented with abdominal distension and anorexia. CT images revealed massive ascites, bowel obstruction and an enlarged intra-abdominal tumour, which was considered progression of the MPeM. The patient was treated with nivolumab. Bowel obstruction was improved after the first administration, and his sense of abdomen distension completely disappeared after the third administration. This case supports the utility of immunotherapy in MPeM.
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Ramakrishnan, Vijay, e Muhammad Arsalan. "A Pressure-Based Multiphase Flowmeter: Proof of Concept". Sensors 23, n. 16 (19 agosto 2023): 7267. http://dx.doi.org/10.3390/s23167267.
Testo completoAbstract (sommario):
Multiphase flowmeters (MPFMs) measure the flow rates of oil, gas, and brine in a pipeline. MPFMs provide remote access to real-time well production data that are essential for efficient oil field operations. Most MPFMs are complex systems requiring frequent maintenance. An MPFM that is operationally simple and accurate is highly sought after in the energy industry. This paper describes an MPFM that uses only pressure sensors to measure gas and liquid flow rates. The design is an integration of a previously developed densitometer with an innovative Venturi-type flowmeter. New computing models with strong analytical foundations were developed, aided by empirical correlations and machine-learning-based flow-regime identification. A prototype was experimentally validated in a multiphase flow loop over a wide range of field-like conditions. The accuracy of the MPFM was compared to that of other multiphase metering techniques from similar studies. The results point to a robust, practical MPFM.
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Oshiobugie, Austin. "Multi-Phase Flow Metering for Offshore Pipeline Leak Detection: Anomaly Detection Using AI Algorithms". International Journal of Electrical and Electronics Engineering Studies 10, n. 1 (15 gennaio 2024): 19–36. http://dx.doi.org/10.37745/ijeees.13/vol10n11936.
Testo completoAbstract (sommario):
Offshore oil and gas operations have long relied on Multi-Phase FlowMetering (MPFM) technology to accurately monitor the flow of oil, gas, and water within pipelines. As offshore pipeline networks expand and age, the risks of undetected leaks grow significantly, leading to economic losses and environmental disasters. Traditional MPFM systems focus on fluid composition and flow rate monitoring but fall short in providing real-time leak detection capabilities. The integration of Artificial Intelligence (AI), specifically anomaly detection algorithms, into MPFM systems presents a promising solution for addressing this critical gap in pipeline monitoring. Anomaly detection using AI involves training predictive models on historical pipeline data to identify irregularities in flow patterns that could signify a leak. By utilizing machine learning techniques such as random forests, k-means clustering, and autoencoders, AI models can detect subtle deviations in pipeline behavior that are often overlooked by conventional monitoring methods. This paper explores the application of AI-driven anomaly detection to offshore pipeline leak detection, offering a comprehensive review of the existing literature on MPFM technology, AI in industrial settings, and the evolving role of predictive analytics in oil and gas operations. The methodology outlines the steps taken to develop and validate a predictive model using historical MPFM data from a real-world offshore pipeline in Nigeria. Through a case study focusing on an offshore pipeline in the Niger Delta, this research demonstrates the effectiveness of AI in identifying leaks before they result in major economic or environmental damage. Results from the case study highlight significant improvements in leak detection accuracy, early identification of leaks, and cost savings through the implementation of AI-enhanced MPFM systems. By integrating real-time data, such as pressure changes, flow rates, and fluid composition, the proposed AI-driven model offers a dynamic approach to pipeline monitoring. This approach not only automates the detection of potential leaks but also reduces the time it takes to identify and mitigate leaks, ultimately leading to enhanced operational efficiency and environmental safety. Additionally, the study explores the economic and environmental impact of early leak detection, emphasizing the importance of incorporating AI into MPFM systems for long-term sustainability in offshore oil and gas operations. The findings of this research suggest that AI has the potential to revolutionize pipeline monitoring by enhancing the capabilities of MPFM systems, making them more responsive to leaks and better equipped to handle the complexities of multi-phase flow in offshore environments. As offshore pipelines become more susceptible to leaks due to age and harsh operational conditions, the integration of AI-driven anomaly detection will be key to ensuring the continued viability and safety of offshore oil and gas infrastructure. This paper concludes by outlining future research directions and recommending best practices for deploying AI-enhanced MPFM systems to optimize leak detection and pipeline integrity management in offshore settings.
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Nomoto, Sukeharu, Masahito Segawa e Makoto Watanabe. "Non- and Quasi-Equilibrium Multi-Phase Field Methods Coupled with CALPHAD Database for Rapid-Solidification Microstructural Evolution in Laser Powder Bed Additive Manufacturing Condition". Metals 11, n. 4 (13 aprile 2021): 626. http://dx.doi.org/10.3390/met11040626.
Testo completoAbstract (sommario):
A solidification microstructure is formed under high cooling rates and temperature gradients in powder-based additive manufacturing. In this study, a non-equilibrium multi-phase field method (MPFM), based on a finite interface dissipation model, coupled with the Calculation of Phase Diagram (CALPHAD) database, was developed for a multicomponent Ni alloy. A quasi-equilibrium MPFM was also developed for comparison. Two-dimensional equiaxed microstructural evolution for the Ni (Bal.)-Al-Co-Cr-Mo-Ta-Ti-W-C alloy was performed at various cooling rates. The temperature-γ fraction profiles obtained under 105 K/s using non- and quasi-equilibrium MPFMs were in good agreement with each other. Over 106 K/s, the differences between the non- and quasi-equilibrium methods grew as the cooling rate increased. The non-equilibrium solidification was strengthened over a cooling rate of 106 K/s. Columnar-solidification microstructural evolution was performed at cooling rates of 5 × 105 K/s to 1 × 107 K/s at various temperature gradient values under a constant interface velocity (0.1 m/s). The results show that, as the cooling rate increased, the cell space decreased in both methods, and the non-equilibrium MPFM was verified by comparing with the quasi-equilibrium MPFM. Our results show that the non-equilibrium MPFM showed the ability to simulate the solidification microstructure in powder bed fusion additive manufacturing.
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KURIBAYASHI, KOZO, KAZUHIRO KITAJIMA, TOSHIYUKI MINAMI, MASATAKA IKEDA, KOICHIRO YAMAKADO e TAKASHI KIJIMA. "Malignant Peritoneal Mesothelioma Features Shown by FDG-PET/CT". Cancer Diagnosis & Prognosis 2, n. 6 (3 novembre 2022): 654–60. http://dx.doi.org/10.21873/cdp.10156.
Testo completoAbstract (sommario):
Background/Aim: Malignant peritoneal meso-thelioma (MPeM) has no specific imaging findings that can distinguish it from other peritoneal tumors and the accuracy of peritoneal cytology is low, therefore definitive diagnosis is usually performed by histology. This study investigated whether 18F-fluorodeoxyglucose positron emission tomography/ computed tomography representing glucose metabolism is a useful modality for identifying biopsy sites using the tumor viability of MPeM. Patients and Methods: Sixty MPeM patients underwent pre-biopsy FDG-PET/CT examination. The findings were retrospectively evaluated, and histopathological subtype differences were investigated. Results: The diffuse MPeM type was found in 45 (75.0%) and the localized type in 15 (25.0%) cases. The most frequent site of occurrence was the peritoneum (91.7%), followed by the omentum (51.7%). FDG-avid results were noted in 55 patients (91.7%), while 5 (8.3%) showed no FDG uptake with a variety of maximum standardize uptake value (SUVmax) values (range=0-16.77, mean=7.32±4.05). In the 53 epithelial cases, mean SUVmax (7.09±4.07, range=0-16.77) was slightly lower compared to the 4 biphasic (8.30±4.70, range=2.35-13.36) and 3 sarcomatoid (10.08±2.64, range=8.21-13.10) cases, without any significant difference (p=0.12). Diffuse and focal disease patterns showed similar percentages in the three types. Six cases (10.0%) had nodal metastases and 6 (10.0%) extra-abdominal metastases. Compared to the biphasic and sarcomatoid groups, nodal metastases were more common in the epithelial group, while extra-abdominal metastases were more often seen in the biphasic and sarcomatoid groups. Ascites was seen in 53 (83.3%), pleural effusion in 43 (71.7%), and pleural plaque in 31 (51.7%) cases. Conclusion: Through reviewing and elucidation of the FDG-PET/CT features of MPeM, it was shown that FDG-PET/CT is an extremely useful modality for identifying biopsy sites of MPeM.
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Mianroodi, Jaber Rezaei, Pratheek Shanthraj, Bob Svendsen e Dierk Raabe. "Phase-Field Modeling of Chemoelastic Binodal/Spinodal Relations and Solute Segregation to Defects in Binary Alloys". Materials 14, n. 7 (5 aprile 2021): 1787. http://dx.doi.org/10.3390/ma14071787.
Testo completoAbstract (sommario):
Microscopic phase-field chemomechanics (MPFCM) is employed in the current work to model solute segregation, dislocation-solute interaction, spinodal decomposition, and precipitate formation, at straight dislocations and configurations of these in a model binary solid alloy. In particular, (i) a single static edge dipole, (ii) arrays of static dipoles forming low-angle tilt (edge) and twist (screw) grain boundaries, as well as at (iii) a moving (gliding) edge dipole, are considered. In the first part of the work, MPFCM is formulated for such an alloy. Central here is the MPFCM model for the alloy free energy, which includes chemical, dislocation, and lattice (elastic), contributions. The solute concentration-dependence of the latter due to solute lattice misfit results in a strong elastic influence on the binodal (i.e., coexistence) and spinodal behavior of the alloy. In addition, MPFCM-based modeling of energy storage couples the thermodynamic forces driving (Cottrell and Suzuki) solute segregation, precipitate formation and dislocation glide. As implied by the simulation results for edge dislocation dipoles and their configurations, there is a competition between (i) Cottrell segregation to dislocations resulting in a uniform solute distribution along the line, and (ii) destabilization of this distribution due to low-dimensional spinodal decomposition when the segregated solute content at the line exceeds the spinodal value locally, i.e., at and along the dislocation line. Due to the completely different stress field of the screw dislocation configuration in the twist boundary, the segregated solute distribution is immediately unstable and decomposes into precipitates from the start.
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Munir, Misbakhul, Marlina Ekawaty e Asfi Manzilati. "Comparison of Sharia Banking Performance in Malaysia and Indonesia According to Maqashid Sharia Perspectives". Journal of Indonesian Applied Economics 12, n. 1 (29 febbraio 2024): 55–68. http://dx.doi.org/10.21776/ub.jiae.2024.012.01.5.
Testo completoAbstract (sommario):
Purpose The research objective was to analyze the difference of sharia banking performance in Malaysia and Indonesia through measurement tool of maqashid index of MPEM and PMMS Design/methodology/approach This research used comparative study quantitative method and secondary data with observation period of 2014-2021. Findings Based on the MPEM index of maqashid sharia, this research result referred that Indonesia was superior in the dimension of preserving religion, maintaining wealth, and continuing offspring. Based on PMMS maqashid sharia index, Malaysia was superior to Indonesia in all indicators consisting of educating individuals and upholding justice and welfare. Research limitations/implications The research objective was to analyze the difference of sharia banking performance in Malaysia and Indonesia through measurement tool of maqashid index of MPEM and PMMS period of 2014-2021 Originality/value The countries in Southeast Asia region have applied this Dual Banking System including Indonesia and Malaysia. The use of different system applied in banking field should affect the difference of performance measurement. MPEM and PMMS were taken as alternatives of maqashid sharia-based banking performance measurement which was more proper if it was functioned to measure the performance of sharia banking.
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Wieser, Markus. "Ziel 10: Krebs bek�mpfen". Sozial- und Pr�ventivmedizin SPM 42, S1 (gennaio 1997): 24–25. http://dx.doi.org/10.1007/bf01326154.
Testo completo
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Kindler, Hedy Lee. "Peritoneal Mesothelioma: The Site of Origin Matters". American Society of Clinical Oncology Educational Book, n. 33 (maggio 2013): 182–88. http://dx.doi.org/10.14694/edbook_am.2013.33.182.
Testo completoAbstract (sommario):
The etiology, gender distribution, pathology, natural history, and treatment options for mesothelioma (MM) differ substantially depending on the site of origin. Peritoneal mesothelioma (MPeM) is a rare disease, comprising only approximately 10% to 15% of the 2,500 cases of MM diagnosed in the United States each year. Patients with MPeM are younger than patients with pleural MM, and a higher proportion, mostly women, are long-term survivors. Most MPeM is caused by asbestos exposure. Germ-line mutations of BAP1 (BRCA associated protein 1) can predispose to MM, uveal melanoma, and potentially other cancers. MPeM can be challenging to diagnose, and cytology is rarely helpful. Review by an experienced pathologist using a panel of at least two positive and two negative immunohistochemical stains is essential. The three major pathologic subtypes are epithelial, sarcomatoid, and biphasic. Most cases are epithelial; the others have a dismal prognosis. Two indolent subtypes of borderline malignant potential—well-differentiated papillary mesothelioma and benign multicystic mesothelioma—are more common in the peritoneum and are treated surgically. In highly selected patients receiving treatment at experienced referral centers, an aggressive locoregional strategy that combines cytoreductive surgery to remove all gross disease and hyperthermic intraperitoneal chemotherapy to treat residual microscopic tumors yields a 3-year survival of 60% and a median survival approaching 5 years, far better than expected from historic controls. This approach also provides durable palliation of malignant ascites in nearly all patients. Pemetrexed is the only U.S. Food and Drug Administration (FDA)–approved systemic chemotherapy for pleural MM. Largely on the basis of data from pharmaceutical registry studies, the activity of pemetrexed-based chemotherapy appears to be similar in pleural MM and MPeM.
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Raghav, Kanwal Pratap Singh, Michael J. Overman, Suyu Liu, Anneleis Willett, Richard Eldon Royal, Anais Malpica, Christopher Scally et al. "A phase II trial of atezolizumab and bevacizumab in patients with relapsed/refractory and unresectable malignant peritoneal mesothelioma." Journal of Clinical Oncology 38, n. 15_suppl (20 maggio 2020): 9013. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.9013.
Testo completoAbstract (sommario):
9013 Background: Malignant peritoneal mesothelioma (MPeM) is an orphan malignancy. No recommended/FDA approved therapies exist for salvage treatment beyond first-line platinum and pemetrexed based chemotherapy. While immune checkpoint inhibition has shown preliminary efficacy in mesotheliomas, data and efficacy is limited in MPeM patients (pts) [objective response rate (ORR) ~ 11%; median progression-free survival (mPFS) ~ 4 months (m); median overall survival (mOS) ~ 11 m]. We aimed to prospectively assess the safety and efficacy of combined anti-PD1 (atezolizumab) and VEGF (bevacizumab) blockade (AtezoBev) in pts with MPeM. Methods: In this phase 2 study, eligible pts with histologically confirmed MPeM, ECOG PS 0-1, and prior platinum and pemetrexed treatment were treated with 1200 mg of atezolizumab and 15 mg/kg of bevacizumab IV every 21 days until disease progression, unacceptable toxicity, or withdrawal. Primary endpoint was confirmed ORR by RECIST 1.1 by independent radiology review. Duration of response (DOR), PFS and OS were pre-specified secondary endpoints. Results: Among 20 enrolled pts (3/2017 - 2/2019), median age was 63 (range, 33-87) years, 12 (60%) were female, 12 (60%) had PS 0, and 2 (10%) had biphasic MPeM. Among 20 evaluable pts (median cycles 14), confirmed ORR was 35% (7 pts; 95% CI: 15.4-59.2) (median DOR 8.8 m). Responses were ongoing in 5/7 (71.4%) pts at data cutoff. The median follow-up was 20.5 months. Six deaths were observed during follow-up, and the 1-year OS was 79% (95% CI: 52 – 91) (median OS ~ NR). Median PFS was estimated as 17.6 m (95% CI: 9.1 – NR). The 1-year PFS was 54% (95% CI: 28 – 74). Grade 3 (no grade 4/5) treatment-emergent adverse events occurred in 10 (50%) pts; most common being hypertension (40%) and anemia (10%). Two (10%) pts had grade 3 immune-related adverse events. Translational studies are ongoing. Conclusions: AtezoBev showed promising and durable efficacy in relapsed/refractory MPeM with acceptable safety profile. Ongoing multiomic analyses of pre and on-treatment tissue/liquid biopsies obtained on all these pts will provide additional insight into mechanisms and biomarkers of response and resistance. Clinical trial information: NCT03074513.
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Lee, Jimmy, Jordan Turetsky, Elham Nasri e Sherise C. Rogers. "Complete clinical remission of malignant peritoneal mesothelioma with systemic pemetrexed and bevacizumab in a patient with a BAP1 mutation". BMJ Case Reports 16, n. 12 (dicembre 2023): e255916. http://dx.doi.org/10.1136/bcr-2023-255916.
Testo completoAbstract (sommario):
Malignant peritoneal mesothelioma (MPeM) is a rare malignancy with historically poor prognosis. Recent research has started to reveal increasingly prevalent genetic mutations seen in this malignancy. Here, we report a case of complete clinical remission of unresectable, metastatic MPeM with systemic chemotherapy. Immunohistochemistry of our patient’s malignant cytology sample showed loss of Breast Cancer Gene 1-associated protein-1 expression (BAP1). The patient had synchronous diagnoses of primary squamous cell carcinoma of the anus, benign schwannoma and meningioma. Following the completion of 18 cycles of pemetrexed and bevacizumab, the patient has remained in clinical remission for 8 months. We examine the unusual susceptibility of unresectable MPeM to systemic chemotherapy and attribute susceptibility to the molecular milieu created by mutations in multiple DNA repair pathways. We encourage increased testing for and analysis of mutations in DNA repair pathways to improve future treatment outcomes in this rare malignancy.
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Andriana, Adinda Vindri, e Rini Rini. "ANALISIS KINERJA PERBANKAN SYARIAH DENGAN MAQASID BASED PERFORMANCE EVALUATION MODEL (MPEM)". Jurnal Wahana Akuntansi 13, n. 1 (25 luglio 2018): 70–94. http://dx.doi.org/10.21009/wahana.13.016.
Testo completoAbstract (sommario):
Penelitian ini bertujuan untuk membobot komponen-komponen penyusun Maqasid based Performance Evaluation Model (MPEM) dan menguji MPEM yang telah di bobot tersebut untuk mengukur kinerja 18 bank syariah dari 9 negara yaitu, Saudi Arabia, Indonesia, Malaysia, Bahrain, Bangladesh, Uni Emirat Arab, Qatar, Kuwait dan Pakistan. Data dalam penelitian ini dikumpulkan dengan 2 cara berbeda sesuai tujuan penelitiannya. Untuk tujuan pembobotan, data dikumpulkan melalui kuesioner yang dikirimkan kepada akademisi dan profesional perbankan syariah. Untuk tujuan pengujian, data dikumpulkan dari laporan tahunan yang dipublikasikan oleh bank syariah atau bank sentral negaranya. Metode convenience sampling digunakan, sehing ga baik sampel responden maupun sampel bank syariah dipilih berdasarkan kem udahan aksesnya terhadap peneliti. Datta dianalisis menggunakan metode Simple Additive Weighting (SAW). Hasil penelitian ini adalah 1) bobot dari tiap komponen MPEM dan 2) peringkat kinerja maqasid al-shari’ah dimana Bank Muamalat Indonesia (BMI) merupakan yang terb aik di antara bank syariah serta Indonesia merupakan yang terbaik antar negara yang diuji.
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Wu, Weitiao, Wenzhou Jin e Luou Shen. "Mixed Platoon Flow Dispersion Model Based on Speed-Truncated Gaussian Mixture Distribution". Journal of Applied Mathematics 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/480965.
Testo completoAbstract (sommario):
A mixed traffic flow feature is presented on urban arterials in China due to a large amount of buses. Based on field data, a macroscopic mixed platoon flow dispersion model (MPFDM) was proposed to simulate the platoon dispersion process along the road section between two adjacent intersections from the flow view. More close to field observation, truncated Gaussian mixture distribution was adopted as the speed density distribution for mixed platoon. Expectation maximum (EM) algorithm was used for parameters estimation. The relationship between the arriving flow distribution at downstream intersection and the departing flow distribution at upstream intersection was investigated using the proposed model. Comparison analysis using virtual flow data was performed between the Robertson model and the MPFDM. The results confirmed the validity of the proposed model.
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Patel, Meera, Jonathan M. Loree, Melissa W. Taggart, Anais Malpica, Aurelio Matamoros, Scott Kopetz, Gauri R. Varadhachary, Keith F. Fournier, Richard Eldon Royal e Kanwal Pratap Singh Raghav. "Malignant peritoneal mesothelioma: Clinicopathological features, prognostic factors, and survival outcomes." Journal of Clinical Oncology 36, n. 4_suppl (1 febbraio 2018): 650. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.650.
Testo completoAbstract (sommario):
650 Background: Peritoneal mesothelioma (PeM) is an orphan disease with approximately 300-400 cases diagnosed in the United States each year. Due to its rarity, data on its presentation and prognostic factors is limited. The purpose of this study was to investigate the clinicopathological profile and outcome of Malignant PeM (MPeM). Methods: We retrospectively reviewed 128 PeM patients (pts) seen at UTMDACC (2011 - 2017) comprised of 111 MPeM and 17 variants (VPeM) [9 well-differentiated papillary and 8 multicystic]. Kaplan-Meier method was used to estimate median overall survival (mOS) and compared with log-rank tests. Results: Median age at diagnosis was 57 yrs. with a higher proportion of women (61%). The mOS for MPeM was significantly shorter than VPeM (HR 3.7, 95% CI: 1.6 – 8.4, P = 0.002). Among pts with MPeM, median age at diagnosis was 56 yrs. and 58% were women. Only 22% had prior exposure to asbestos. Epithelioid subtype was seen in 94 (85%) pts. Calretinin and WT-1 IHC were positive in 98% and 96% of cases. BerEP4 and MOC-31 IHC were negative in 90% and 84% of cases. After median follow-up of 31 months (m), the mOS for MPeM cohort was 78 m. In univariate analysis, age, prior asbestos exposure, ECOG PS, histologic subtype, CA125, neutrophil-lymphocyte ratio (NLR) and cytoreductive surgery (CRS) were found to be associated with OS. In multivariate analyses, age ≥ 65 years (HR 4.5, 95% CI: 1.3 - 15.2, P = 0.02), prior asbestos exposure (HR 4.1, 95% CI: 1.1 – 15.6, P = 0.04), poor PS (ECOG 2/3) (HR 8.9, 95% CI: 1.7 – 47.7, P = 0.01), elevated CA125 ( > 3X upper limit of normal) (HR 4.5, 95% CI: 1.3 – 15.5, P = 0.02), and high NLR (HR 3.8, 95% CI: 1.1 – 12.6, P = 0.03) were found to be independently associated with poor OS. A total of 50 (45%) pts underwent CRS and among these the completion of cytoreduction score (CCS) was strongly associated with OS (mOS: 201 m, 53 m and 36 m for CCS 0, 1, 2/3, respectively, P = 0.005). Conclusions: MPeM is associated with poor survival outcomes. Prognostic factors include age, history of asbestos exposure, CA-125 level, NLR, and PS. CRS with CCS 0 results in favorable survival. Further understanding of molecular genetics is warranted to improve prognostication and outcomes.
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El-Saman, A. A. M. A. "Modern Financial Tools’ Impact on Public Financial Management: The Case of Egypt". Finance: Theory and Practice 26, n. 6 (31 dicembre 2022): 175–91. http://dx.doi.org/10.26794/2587-5671-2022-26-6-175-191.
Testo completoAbstract (sommario):
The purpose of this study is to examine the managerial impacts of applying modern public financial management (MPFM) tools in financial reform programs on the efficiency of public financial management (PFM) in developing countries, considering the case of the Egyptian reform program implemented during 2005–2015. Applying MPFM tools could improve the efficiency of PFM in developing countries if institutional factors are available to ensure their successful implementation in reform programs. The study adopted a descriptive-analytical method to describe the managerial impact of applying MPFM tools in the financial reform experiences in developing countries. It employed a case study approach on the Egyptian reform experiment to estimate the correlation between applying modern financial tools and the managerial efficiency of PFM assessed through three elements: operational efficiency, allocative efficiency, and financial discipline. The practical study used the IBM SPSS package and MS-Excel to process the data. The results found a positive correlation between the application of modern financial tools and the rate of improvement in the efficiency of PFM in the Egyptian reform program. The study developed a specific model for a deeper understanding of the impacts of MPFM tools on the efficiency of PFM. The model highlighted a strong positive correlation between the successful application of modern PFM tools and the efficiency of PFM and underscored that the availability of the required realtime financial information about governmental revenue and more control over public spending led to achieving financial discipline.
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Su, Shan-shan, Guo-qi Zheng, Wen-jie Yin, Yu-fei Liang, Ying-ying Liu, Hui Song, Ning-ning Sun e Yu-xin Yang. "Prognostic Significance of Blood, Serum, and Ascites Parameters in Patients with Malignant Peritoneal Mesothelioma or Peritoneal Carcinomatosis". Gastroenterology Research and Practice 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/2619526.
Testo completoAbstract (sommario):
To determine effects of the biochemical and cytological properties of blood, serum, and ascites on survival of patients with malignant peritoneal effusion (MPeE), including malignant peritoneal mesothelioma (MPeM) and peritoneal carcinomatosis (PC), we conducted a retrospective study of patients with MPeE and healthy controls. Potential prognostic factors were identified as follows: age, sex, blood neutrophil-to-lymphocyte ratio (NLR), serum parameters, ascites parameters, serum-ascites albumin gradient, and the ascites-serum LDH ratio. Compared to those of the control group, serum albumin levels were significantly lower, and the NLR and serum LDH levels were significantly higher in the MPeE group. Overall survival (OS) was longer in patients with MPeM compared to that in patients with PC. Compared with patients in the MPeM, patients with PC had higher NLRs, ascites glucose levels, serum-ascites albumin gradients, and serum LDH levels. In contrast, their ascites albumin levels and ascites-serum LDH ratios were lower. Univariate analyses indicated that the NLR, serum LDH levels, ascites LDH levels, ascites coenocyte levels, and the ascites coenocyte-to-monocyte ratios affected the OS. Multivariate analyses identified only serum and ascites LDH levels as independent prognostic factors.
40
Sriwidodo, Sriwidodo, Reza Pratama, Abd Kakhar Umar, Anis Yohana Chaerunisa, Afifah Tri Ambarwati e Nasrul Wathoni. "Preparation of Mangosteen Peel Extract Microcapsules by Fluidized Bed Spray-Drying for Tableting: Improving the Solubility and Antioxidant Stability". Antioxidants 11, n. 7 (6 luglio 2022): 1331. http://dx.doi.org/10.3390/antiox11071331.
Testo completoAbstract (sommario):
Mangosteen fruit has been widely consumed and used as a source of antioxidants, either in the form of fresh fruit or processed products. However, mangosteen peel only becomes industrial waste due to its bitter taste, low content solubility, and poor stability. Therefore, this study aimed to design mangosteen peel extract microcapsules (MPEMs) and tablets to overcome the challenges. The fluidized bed spray-drying method was used to develop MPEM, with hydroxypropyl methylcellulose (HPMC) as the core mixture and polyvinyl alcohol (PVA) as the coating agent. The obtained MPEM was spherical with a hollow surface and had a size of 411.2 µm. The flow rate and compressibility of MPEM increased significantly after granulation. A formula containing 5% w/w polyvinyl pyrrolidone K30 (PVP K30) as a binder had the best tablet characteristics, with a hardness of 87.8 ± 1.398 N, friability of 0.94%, and disintegration time of 25.75 ± 0.676 min. Microencapsulation of mangosteen peel extract maintains the stability of its compound (total phenolic and α-mangosteen) and its antioxidant activity (IC50) during the manufacturing process and a month of storage at IVB zone conditions. According to the findings, the microencapsulation is an effective technique for improving the solubility and antioxidant stability of mangosteen peel extract during manufacture and storage.
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Klippel, Marcelo, José Antonio Valle Antunes Júnior e Guilherme Luís Roehe Vaccaro. "Matriz de posicionamento estratégico de materiais: conceito, método e estudo de caso". Gestão & Produção 14, n. 1 (aprile 2007): 181–92. http://dx.doi.org/10.1590/s0104-530x2007000100015.
Testo completoAbstract (sommario):
A gestão de materiais representa uma questão de interesse na gestão de operações, uma vez que pode reduzir ou promover a flexibilidade do ambiente produtivo, e por conseqüência, impactar os resultados globais da organização. Este artigo apresenta os principais conceitos para sustentação e implantação da matriz de posicionamento estratégico de materiais (MPEM) e discute a necessidade de gerenciar eficazmente os materiais no contexto produtivo. Adicionalmente, apresenta um estudo de caso de uma empresa industrial do ramo metal mecânico sugerindo elementos metodológicos para implantação da MPEM. Finalmente, é salientada a importância da gestão contínua dos materiais, envolvendo a segmentação da gestão nos diferentes quadrantes da matriz e utilizando um mecanismo de indicadores de desempenho adotadas pela empresa.
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Rasul, Kakil Ibrahim, e David J. Kerr. "Malignant peritoneal mesothelioma. Is there a new treatment?" Rare Tumors 1, n. 2 (1 dicembre 2009): 150–52. http://dx.doi.org/10.4081/rt.2009.e49.
Testo completoAbstract (sommario):
The authors report a novel, alternative approach to treat malignant peritoneal mesothelioma (MPeM) targeting, vascular endothelial growth factor (VEGF) using anti-VEGF (bevacizumab) chemotherapy combination.
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Singh, Navneet, Valliappan Muthu, Kuruswamy Thurai Prasad e Milind Baldi. "Overall survival in PEMVITASTART randomized trial comparing immediate vs. conventional strategies of vitamin supplementation in NSCLC patients on 1st line pemetrexed-platinum chemotherapy." Journal of Clinical Oncology 37, n. 15_suppl (20 maggio 2019): e20538-e20538. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e20538.
Testo completoAbstract (sommario):
e20538 Background: PEMVITASTART ( NCT02679443 ) was an open label phase II randomized trial [Singh N, et al. Cancer (DOI: 10.1002/cncr.32028)] involving locally advanced/metastatic non-squamous NSCLC patients treated with 1st line pemetrexed-platinum chemotherapy (CTx). The trial assessed the hematological toxicity profile in Delayed Arm (DA; conventional strategy) in whom CTx was initiated after 5-7 days of vitamin B12/folate supplementation (B12-FAS) vs. Immediate Arm (IA) in whom patients received B12-FAS simultaneously (≤24 hours) with CTx initiation. All outcomes were reported in modified ITT population (patients who received ≥1 cycle). A non-significant trend towards better radiological responses was observed in IA (PR 33% vs. 18%; p = 0.06). Herein, we report exploratory post-hoc analysis of overall survival (OS) for the mITT population (n = 150; 77 IA, 73 DA) of PEMVITASTART. Methods: OS was calculated from date of enrolment to date of death/last follow up. Survival cutoff date was 28 months after last patient enrolment. Median OS was calculated by Kaplan-Meier method and group differences analyzed by log-rank test. Factors affecting OS were assessed by Cox proportional hazards (CPH) analysis and hazard ratios [HRs] with 95% confidence intervals (CIs) calculated (from univariate and stepwise multivariate models). Results: Median OS was 12.7 m (95% CI 8.0–17.4) and did not differ between IA [15.0 m (10.5-19.4)] and DA [11.7 m (4.1-19.3)]. 1 yr and 2 yr survival rates were similar (IA 42% and 21% vs. DA 44% and 23%). On univariate CPH analysis, factors associated with better OS were female gender, ECOG PS 0, absence of metastatic disease and receipt of maintenance pemetrexed CTx (mPEM) while current/ex-smoker status, disease progression (as best response) and age ≥70 years were a/w worse OS. Baseline Hb and homocysteine (both assessed as continuous variables) and receipt of packed RBC transfusions/ESAs for anemia correction did not influence OS. On multivariate CPH analysis, current/ex-smokers HR 2.2 (95% CI 1.3-3.7; p < 0.01) and mPEM HR 0.5 (95% CI 0.3-0.9; p = 0.01) were both significant. Median OS for current/ex-smokers was 7.4m (95% CI 5.4-9.4) vs. 25.6m (95% CI 16.2-35.0) for non-smokers (log rank p < 0.001) while for patients receiving mPEM, it was 22.7m (95% CI 9.9-35.4) vs. 9.7m (95% CI 4.9-14.5) for those not receiving mPEM (log rank p = 0.02). Conclusions: Smoking status and mPEM were strong and independent prognostic factors for OS in the PEMVITASTART trial. Clinical trial information: NCT02679443.
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Simon, George R., Claire F. Verschraegen, Pasi A. Jänne, Corey J. Langer, Afshin Dowlati, Shirish M. Gadgeel, Karen Kelly et al. "Pemetrexed Plus Gemcitabine As First-Line Chemotherapy for Patients With Peritoneal Mesothelioma: Final Report of a Phase II Trial". Journal of Clinical Oncology 26, n. 21 (20 luglio 2008): 3567–72. http://dx.doi.org/10.1200/jco.2007.15.2868.
Testo completoAbstract (sommario):
PurposePemetrexed in combination with cisplatin is approved for the treatment of pleural mesothelioma and is active in malignant peritoneal mesothelioma (MPeM). Pemetrexed and gemcitabine are synergistic in preclinical models, but the activity of this combination in MPeM is unknown. This clinical study assessed safety and efficacy of pemetrexed plus gemcitabine in chemotherapy-naïve patients with MPeM.Patients and MethodsTreatment consisted of gemcitabine 1,250 mg/m2on days 1 and 8, and pemetrexed 500 mg/m2on day 8, administered immediately before gemcitabine. Treatment was repeated every 21 days for six cycles or until disease progression. All patients received folic acid, vitamin B12, and dexamethasone supplementation. End points included tumor response, toxicity, time to disease progression (TTPD), and overall survival (OS). Disease control rate (DCR) was also calculated.ResultsTwenty patients were enrolled between December 2002 and May 2004. The confirmed response rate was 15% (95% CI, 3.2% to 37.9%), with three patients experiencing a partial response. The DCR was 50% (95% CI, 27.2% to 72.8%). The most common grade 3 to 4 nonhematologic toxicities included fatigue (20%), constipation (10%), vomiting (10%), and dehydration (10%). Hematologic toxicities included grade 3 to 4 neutropenia (60%) and febrile neutropenia (10%). One patient death was attributed to treatment. Median TTPD and OS times were 10.4 months and 26.8 months, respectively.ConclusionThe combination of pemetrexed plus gemcitabine was active in patients with MPeM with a notably high incidence of neutropenia. Median TTPD and OS seem promising. This regimen may provide an alternative to standard therapies, especially for patients who cannot tolerate a platinum-based regimen.
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Ali, Sajedian, Mohaghegh Shahab, Kenoth Sasidharan Adiyodi, Dashtbayaz Maryam, Kohshour Iman Oraki, Alkalby Yasir e Shittu Afeez. "AI-Based Smart Proxy Models for Accurate Oil Rate Prediction and Efficient Pipeline Monitoring". Annals of Marine Science 8, n. 1 (17 ottobre 2024): 042–54. http://dx.doi.org/10.17352/ams.000048.
Testo completoAbstract (sommario):
This research develops an advanced AI-based smart proxy model to significantly enhance the prediction of oil rates and the monitoring of crucial operational parameters such as temperature and pressure in oil field pipeline management. By integrating real-time data from Multiphase Flow Meters (MPFM) with sophisticated simulation outputs, the study introduces a dual-model approach that overcomes the limitations of traditional methods, improving both efficiency and cost-effectiveness. Model 1 employs high-precision real-time MPFM data to provide accurate oil rate predictions. By focusing on critical control points within expansive pipeline networks, this model strategically reduces dependency on extensive MPFM deployment, achieving substantial cost reductions while maintaining rigorous measurement standards. The incorporation of real-time data ensures immediate responsiveness to operational changes, facilitating accurate and reliable insights essential for effective pipeline management. Model 2 utilizes an AI-driven smart proxy to refine the outputs of conventional flow simulators such as OLGA. This model addresses computational challenges including high runtime and numerical convergence issues by selecting the most reliable and accurate simulation outputs. It provides rapid and dependable insights into flow dynamics, supporting timely operational decisions and proactive management that enhance the safety and efficiency of pipeline networks. The integration of Model 1 and Model 2 ensures localized precision and extends analytical capabilities across the entire pipeline network, significantly enhancing predictive accuracy. This harmonized approach not only sets new standards for flow assurance and pipeline management but also illustrates the transformative impact of AI on operational strategies in the hydrocarbon sector.
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Montoya Giraldo, Oscar Danilo, Alejandro Grajales, Luis Fernando Grisales e Carlos A. Castro. "Ubicación y operación eficiente de almacenadores de energía en micro-redes en presencia de generación distribuida". Revista CINTEX 22, n. 1 (2 ottobre 2017): 97–117. http://dx.doi.org/10.33131/24222208.290.
Testo completoAbstract (sommario):
En este trabajo se propone una metodología eficiente para la localización y operación óptima de almacenadores de energía (AE) en micro-redes (MR) a través de un modelo de programación lineal entera mixta (MPLEM). El modelo matemático desarrollado corresponde a un modelo de despacho económico para miro-redes (DEMR) con presencia de generación distribuida (GD) a partir de recursos energéticos renovables. Como función objetivo se considera la minimización de los costos de compra de energía en la bolsa por parte del agente operador de red, teniendo en cuenta dos escenarios de operación; el primero considera un precio de energía fijo; y el segundo, precios variables en el nodo que conecta la MR al sistema de potencia para un horizonte operativo de 24 horas. Como restricciones se consideran los flujos de potencia por la línea a través de un modelo de flujo en redes, las capacidades de almacenamiento de los AE y las capacidades horarias de generación de potencia en los GD. Para resolver el MPLEM propuesto se emplea el paquete de optimización comercial GAMS, empleando el solver CPLEX. La metodología propuesta permite localizar, dimensionar y operar los AE, considerando como horizonte de operación, un día típico laboral en Colombia, adicionalmente se tienen en cuenta diferentes consignas operativas en la operación de los AE según los estándares existentes. Con el fin de conocer las variables de estado de la MR, es empleado un flujo de potencia del tipo barrido iterativo para evaluar las respuestas obtenidas por el MPLEM. Esta evaluación permite hallar los costos operativos reales de la MR. Para validar el modelo matemático propuesto es empleado un sistema de prueba de la literatura especializada de 7 nodos con presencia de dos generadores distribuidos, siendo uno de tipo fotovoltaico y el otro tipo eólico. Los resultados obtenidos muestran la eficiencia de la metodología propuesta, así como su facilidad de implementación y la capacidad de adaptación para sistemas de mayor tamaño.
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Meutia, Inten, Shelly Febriana e Eka Meirawati. "Islamic Bank Performance (Maqasid Sharia Approach)". Integrated Journal of Business and Economics 4, n. 3 (16 novembre 2020): 320. http://dx.doi.org/10.33019/ijbe.v4i3.327.
Testo completoAbstract (sommario):
This study aims to analyze the performance of Islamic banks in Indonesia from the perspective of Maqasid Sharia. For this reason, this study uses two approaches, namely Maqasid Based Performance Evaluation Model (MPEM) and Performance Measurement based on Islamic Maqasid (PMMS). The use of these two approaches is to determine which approach is more appropriate for measuring the performance of Islamic banks. This research is a comparative study that will use a content analysis approach in exploring and analyzing Islamic bank performance data derived from annual reports. To identify bank performance, this study uses data sourced from the annual reports of 9 Islamic Commercial Banks in Indonesia for the period 2016 to 2019. A total of 36 annual reports analyzed in this study. The comparative analysis shows that performance measurement using the MPEM method resulted in higher performance outcomes than the PMMS method. This result proved significant at the five percent level.
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Allam, Joelle, Li Ma, Jeannelyn Estrella, Anneleis Willett, Karen A. Beaty, Aurelio Matamoros, Elizabeth A. Lano et al. "Utility of gene expression–based cancer classification in diagnosis of malignant peritoneal mesothelioma (MPeM): Filling in the gaps in standard pathologic work-up for a rare cancer." Journal of Clinical Oncology 42, n. 3_suppl (20 gennaio 2024): 728. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.728.
Testo completoAbstract (sommario):
728 Background: Malignant peritoneal mesothelioma (MPeM) is a rare cancer (incidence of 0.12 per 100,000) and an arduous diagnostic challenge, requiring skillful evaluation by expert pathologists. Subjective and experiential immunophenotyping coupled with inattention to this rare entity causes delayed or misdiagnosis and leads to suboptimal treatment and outcomes. Gene-expression-based cancer classification offers an objective molecular assessment of the tissue of origin for cancers with uncertain diagnosis and improves diagnostic accuracy for MPeM compared to standard pathology. Methods: We retrospectively evaluated 23 patients (pts) with cancer of unknown primary (CUP) or uncertain diagnoses, with peritoneal/retroperitoneal carcinomatosis and reported as malignant mesothelioma using a 92-gene assay (CancerTYPE ID), a validated classifier for predicting tumor types, between January 2013 to December 2016. Pathology was verified by central review. Clinicopathologic data including immunohistochemistry (IHC) was collected using archived pathology specimens and reports. Results: Pts had a median age of 64 years (range: 39 – 93) at diagnosis, 57% were females and 74% had biopsy from omentum/peritoneum. Original histopathology was reported as poorly differentiated in 81% and as adenocarcinoma, carcinoma and malignant neoplasm in 10 (43%), 7 (30%) and 6 (27%) of cases, respectively. The number of IHC stains performed ranged between 0 and 28 (median: 10). Key IHC stains are shown in the table. Conclusions: In this cohort of CUP or uncertain diagnoses with a molecular cancer classification of malignant mesothelioma, we found huge variability and critical gaps in pathological work-up. Integration of molecular cancer classification using the 92-gene assay helped resolve this diagnostic uncertainty, further supporting its clinical utility to complement standard pathology. The impact of these findings goes beyond just MPeM and may benefit numerous pts with orphan cancers, who account for nearly 20% of all cancers diagnosed globally. [Table: see text]
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Meyer, Gabriele, R. Gellert, G. Schl�mer e I. M�hlhauser. "Thromboseprophylaxestr�mpfe in der Chirurgie?optional oder obligat?" Der Chirurg 75, n. 1 (1 gennaio 2004): 45–58. http://dx.doi.org/10.1007/s00104-003-0742-3.
Testo completo
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Song, Yanhua, Yi Wang, Lan Xu e Mingdi Wang. "Fabrication and Characterization of Electrospun Aligned Porous PAN/Graphene Composite Nanofibers". Nanomaterials 9, n. 12 (15 dicembre 2019): 1782. http://dx.doi.org/10.3390/nano9121782.
Testo completoAbstract (sommario):
A modified parallel electrode method (MPEM), conducted by placing a positively charged ring between the needle and the paralleled electrode collector, was presented to fabricate aligned polyacrylonitrile/graphene (PAN/Gr) composite nanofibers (CNFs) with nanopores in an electrospinning progress. Two kinds of solvents and one kind of nanoparticle were used to generate pores on composite nanofibers. The spinning parameters, such as the concentration of solute and solvent, spinning voltage and spinning distance were discussed, and the optimal parameters were determined. Characterizations of the aligned CNFs with nanopores were investigated by scanning electron microscopy (SEM), fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) analysis, transmission electron microscopy (TEM), high-resistance meter, and other methods. The results showed that graphene (Gr) nanoparticles were successfully introduced into aligned CNFs with nanopores and almost aligned along the axis of the CNFs. The MPEM method could make hydrophobic materials more hydrophobic, and improve the alignment degree and conductive properties of electrospun-aligned CNFs with nanopores. Moreover, the carbonized CNFs with nanopores, used as an electrode material, had a smaller charge-transfer resistance, suggesting potential application in electrochemical areas and electron devices.