Bibliografie tematiche / Mitochondrial DNA replication

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Letteratura scientifica selezionata sul tema "Mitochondrial DNA replication"

Autore: Grafiati
Pubblicato: 11 gennaio 2025

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Articoli di riviste sul tema "Mitochondrial DNA replication"

1

Almannai, Mohammed, Ayman W. El-Hattab, and Fernando Scaglia. "Mitochondrial DNA replication: clinical syndromes." Essays in Biochemistry 62, no. 3 (2018): 297–308. http://dx.doi.org/10.1042/ebc20170101.

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Abstract (sommario):
Each nucleated cell contains several hundreds of mitochondria, which are unique organelles in being under dual genome control. The mitochondria contain their own DNA, the mtDNA, but most of mitochondrial proteins are encoded by nuclear genes, including all the proteins required for replication, transcription, and repair of mtDNA. MtDNA replication is a continuous process that requires coordinated action of several enzymes that are part of the mtDNA replisome. It also requires constant supply of deoxyribonucleotide triphosphates(dNTPs) and interaction with other mitochondria for mixing and unif
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Brieba. "Structure–Function Analysis Reveals the Singularity of Plant Mitochondrial DNA Replication Components: A Mosaic and Redundant System." Plants 8, no. 12 (2019): 533. http://dx.doi.org/10.3390/plants8120533.

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Abstract (sommario):
Plants are sessile organisms, and their DNA is particularly exposed to damaging agents. The integrity of plant mitochondrial and plastid genomes is necessary for cell survival. During evolution, plants have evolved mechanisms to replicate their mitochondrial genomes while minimizing the effects of DNA damaging agents. The recombinogenic character of plant mitochondrial DNA, absence of defined origins of replication, and its linear structure suggest that mitochondrial DNA replication is achieved by a recombination-dependent replication mechanism. Here, I review the mitochondrial proteins possib
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Bradshaw, Patrick C., and David C. Samuels. "A computational model of mitochondrial deoxynucleotide metabolism and DNA replication." American Journal of Physiology-Cell Physiology 288, no. 5 (2005): C989—C1002. http://dx.doi.org/10.1152/ajpcell.00530.2004.

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Abstract (sommario):
We present a computational model of mitochondrial deoxynucleotide metabolism and mitochondrial DNA (mtDNA) synthesis. The model includes the transport of deoxynucleosides and deoxynucleotides into the mitochondrial matrix space, as well as their phosphorylation and polymerization into mtDNA. Different simulated cell types (cancer, rapidly dividing, slowly dividing, and postmitotic cells) are represented in this model by different cytoplasmic deoxynucleotide concentrations. We calculated the changes in deoxynucleotide concentrations within the mitochondrion during the course of a mtDNA replicat
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Falkenberg, Maria. "Mitochondrial DNA replication in mammalian cells: overview of the pathway." Essays in Biochemistry 62, no. 3 (2018): 287–96. http://dx.doi.org/10.1042/ebc20170100.

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Abstract (sommario):
Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA genome and a dedicated DNA replication machinery is required for its maintenance. Many disease-causing mutations affect mitochondrial replication factors and a detailed understanding of the replication process may help to explain the pathogenic mechanisms underlying a number of mitochondrial diseases. We here give a brief overview of DNA replication in mammalian mitochondria, describing our current understanding of this process and some unanswered questions remaining.
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Meeusen, Shelly, and Jodi Nunnari. "Evidence for a two membrane–spanning autonomous mitochondrial DNA replisome." Journal of Cell Biology 163, no. 3 (2003): 503–10. http://dx.doi.org/10.1083/jcb.200304040.

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Abstract (sommario):
The unit of inheritance for mitochondrial DNA (mtDNA) is a complex nucleoprotein structure termed the nucleoid. The organization of the nucleoid as well as its role in mtDNA replication remain largely unknown. Here, we show in Saccharomyces cerevisiae that at least two populations of nucleoids exist within the same mitochondrion and can be distinguished by their association with a discrete proteinaceous structure that spans the outer and inner mitochondrial membranes. Surprisingly, this two membrane–spanning structure (TMS) persists and self-replicates in the absence of mtDNA. We tested whethe
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Bailey, Laura J., and Aidan J. Doherty. "Mitochondrial DNA replication: a PrimPol perspective." Biochemical Society Transactions 45, no. 2 (2017): 513–29. http://dx.doi.org/10.1042/bst20160162.

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Abstract (sommario):
PrimPol, (primase–polymerase), the most recently identified eukaryotic polymerase, has roles in both nuclear and mitochondrial DNA maintenance. PrimPol is capable of acting as a DNA polymerase, with the ability to extend primers and also bypass a variety of oxidative and photolesions. In addition, PrimPol also functions as a primase, catalysing the preferential formation of DNA primers in a zinc finger-dependent manner. Although PrimPol's catalytic activities have been uncovered in vitro, we still know little about how and why it is targeted to the mitochondrion and what its key roles are in t
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Holt, I. J., and A. Reyes. "Human Mitochondrial DNA Replication." Cold Spring Harbor Perspectives in Biology 4, no. 12 (2012): a012971. http://dx.doi.org/10.1101/cshperspect.a012971.

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Billard, Pauline, and Delphine A. Poncet. "Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing." International Journal of Molecular Sciences 20, no. 19 (2019): 4959. http://dx.doi.org/10.3390/ijms20194959.

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Abstract (sommario):
Senescence is defined as a stress-induced durable cell cycle arrest. We herein revisit the origin of two of these stresses, namely mitochondrial metabolic compromise, associated with reactive oxygen species (ROS) production, and replicative senescence, activated by extreme telomere shortening. We discuss how replication stress-induced DNA damage of telomeric DNA (telDNA) and mitochondrial DNA (mtDNA) can be considered a common origin of senescence in vitro, with consequences on ageing in vivo. Unexpectedly, mtDNA and telDNA share common features indicative of a high degree of replicative stres
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Holmes, J. Bradley, Gokhan Akman, Stuart R. Wood, et al. "Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication." Proceedings of the National Academy of Sciences 112, no. 30 (2015): 9334–39. http://dx.doi.org/10.1073/pnas.1503653112.

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Abstract (sommario):
Encoding ribonuclease H1 (RNase H1) degrades RNA hybridized to DNA, and its function is essential for mitochondrial DNA maintenance in the developing mouse. Here we define the role of RNase H1 in mitochondrial DNA replication. Analysis of replicating mitochondrial DNA in embryonic fibroblasts lacking RNase H1 reveals retention of three primers in the major noncoding region (NCR) and one at the prominent lagging-strand initiation site termed Ori-L. Primer retention does not lead immediately to depletion, as the persistent RNA is fully incorporated in mitochondrial DNA. However, the retained pri
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Menger, Katja E., Alejandro Rodríguez-Luis, James Chapman, and Thomas J. Nicholls. "Controlling the topology of mammalian mitochondrial DNA." Open Biology 11, no. 9 (2021): 210168. http://dx.doi.org/10.1098/rsob.210168.

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Abstract (sommario):
The genome of mitochondria, called mtDNA, is a small circular DNA molecule present at thousands of copies per human cell. MtDNA is packaged into nucleoprotein complexes called nucleoids, and the density of mtDNA packaging affects mitochondrial gene expression. Genetic processes such as transcription, DNA replication and DNA packaging alter DNA topology, and these topological problems are solved by a family of enzymes called topoisomerases. Within mitochondria, topoisomerases are involved firstly in the regulation of mtDNA supercoiling and secondly in disentangling interlinked mtDNA molecules f
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Tesi sul tema "Mitochondrial DNA replication"

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Bowmaker, Mark Richard. "Replication of the mouse mitochondrial DNA." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614689.

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Korhonen, Jenny. "Functional and structural characterization of the human mitochondrial helicase /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-102-2/.

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Cluett, Tricia Joy. "The mechanism of mammalian mitochondrial DNA replication." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611167.

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Dzionek, Karol Wiktor. "The relationship between mitochondrial DNA transcription and replication." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648311.

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Duch, Anna Marta. "In organello studies of mammalian mitochondrial DNA replication." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648093.

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Bailey, L. J. "Mitochondrial DNA metabolism : organisation, structure, and replication stalling." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596253.

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Abstract (sommario):
A mouse model was generated that accumulates multiple point mutations throughout the mitochondrial genome, due to an exonuclease deficient DNA polymerase. The work described here has focused on studying the structure of the mitochondrial genome of these mice and has shown that these mice suffer an increase in replication stalling. Breakage of stalled molecules at specific points, leads to the generation of a linear 11 kb DNA molecule and aborts replication. It is proposed here that these numerous rounds of futile replication lead to ‘cellular exhaustion’ and therefore the premature ageing phen
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Gooding, Christopher Michael. "Mitochondrial DNA replication and transmission in Saccharomyces cerevisiae." Thesis, University of Hertfordshire, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303447.

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Spikings, Emma Catherine. "Mitochondrial DNA replication in pre-implantation embryonic development." Thesis, University of Birmingham, 2007. http://etheses.bham.ac.uk//id/eprint/45/.

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Abstract (sommario):
All eukaryotic cells possess mitochondrial DNA (mtDNA), which is maternally inherited through the oocyte, its replication being regulated by nuclear-encoded replication factors. It was hypothesised that mtDNA replication is highly regulated in oocytes, pre-implantation embryos and embryonic stem cells (ESCs) and that this may be disrupted following nuclear transfer (NT). MtDNA copy number decreased between 2-cell and 8-cell staged porcine embryos and increased between the morula and expanded blastocyst stages, coinciding with increased expression of mtDNA replication factors. Competent porcine
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Johnson, Allison Anne. "Fidelity of replication by the mitochondrial DNA polymerase and toxicity of nucleoside analogs /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004298.

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Sage, Jay M. "Support of Mitochondrial DNA Replication by Human Rad51: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/574.

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Abstract (sommario):
The function of homologous DNA recombination in human mitochondria has been a topic of ongoing debate for many years, with implications for fields ranging from DNA repair and mitochondrial disease to population genetics. While genetic and biochemical evidence supports the presence of a mitochondrial recombination activity, the purpose for this activity and the proteins involved have remained elusive. The work presented in this thesis was designed to evaluate the mitochondrial localization of the major recombinase protein in human cells, Rad51, as well as determine what function it plays in the
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Libri sul tema "Mitochondrial DNA replication"

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MITOCHONDRIAL DNA DOUBLE-STRAND BREAKS: IN REPLICATION AND IN REPAIR. Louisiana State University Health Sciences Center-Shreveport, Louisiana, USA, 2017.

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Replikation des mobilen Introns (plDNA) in Mitochondrien von Podospora anserina: Mechanismus und Auswirkungen auf die Alterung des Pilzes. J. Cramer, 1994.

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Capitoli di libri sul tema "Mitochondrial DNA replication"

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Keshav, Kylie F., and Shonen Yoshida. "Mitochondrial DNA Replication." In Mitochondrial DNA Mutations in Aging, Disease and Cancer. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-662-12509-0_5.

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Annuario, Emily, Kristal Ng, and Alessio Vagnoni. "High-Resolution Imaging of Mitochondria and Mitochondrial Nucleoids in Differentiated SH-SY5Y Cells." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1990-2_15.

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Abstract (sommario):
AbstractMitochondria are highly dynamic organelles which form intricate networks with complex dynamics. Mitochondrial transport and distribution are essential to ensure proper cell function, especially in cells with an extremely polarised morphology such as neurons. A layer of complexity is added when considering mitochondria have their own genome, packaged into nucleoids. Major mitochondrial morphological transitions, for example mitochondrial division, often occur in conjunction with mitochondrial DNA (mtDNA) replication and changes in the dynamic behaviour of the nucleoids. However, the relationship between mtDNA dynamics and mitochondrial motility in the processes of neurons has been largely overlooked. In this chapter, we describe a method for live imaging of mitochondria and nucleoids in differentiated SH-SY5Y cells by instant structured illumination microscopy (iSIM). We also include a detailed protocol for the differentiation of SH-SY5Y cells into cells with a pronounced neuronal-like morphology and show examples of coordinated mitochondrial and nucleoid motility in the long processes of these cells.
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Holt, Ian J., Antonella Spinazzola, Mirian C. H. Janssen, and Johannes N. Spelbrink. "Disorders of Replication, Transcription and Translation of Mitochondrial DNA." In Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-67727-5_45.

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Oliveira, Marcos T., and Laurie S. Kaguni. "Comparative Purification Strategies for Drosophila and Human Mitochondrial DNA Replication Proteins: DNA Polymerase γ and Mitochondrial Single-Stranded DNA-Binding Protein." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-521-3_3.

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Goffart, Steffi, and Jaakko Pohjoismäki. "Analysis of Mitochondrial DNA Replication by Two-Dimensional Agarose Gel Electrophoresis." In Methods in Molecular Biology. Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2922-2_18.

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John, Justin C. St, and Keith H. S. Campbell. "The Consequences of Reprogramming a Somatic Cell for Mitochondrial DNA Transmission, Inheritance and Replication." In Nuclear Reprogramming and Stem Cells. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-225-0_8.

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Hidaka, Takuya. "Allele-Specific Replication Inhibition of Mitochondrial DNA by MITO-PIP Conjugated with Alkylation Reagent." In Springer Theses. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-8436-4_3.

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Kolesar, Jill E., and Brett A. Kaufman. "Using Two-Dimensional Intact Mitochondrial DNA (mtDNA) Agarose Gel Electrophoresis (2D-IMAGE) to Detect Changes in Topology Associated with Mitochondrial Replication, Transcription, and Damage." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0323-9_3.

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de Haas, Jan M., Frank Kors, Ad J. Kool, and H. John J. Nijkamp. "Isolation of Putative Petunia Hybrida Chloroplast and Mitochondrial Replication Origins and Analysis of the Initiation of DNA Synthesis." In Plant Molecular Biology. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4615-7598-6_87.

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Kobayashi, Yuki, Yu Kanesaki, Mitsumasa Hanaoka, and Kan Tanaka. "Control of Cell Nuclear DNA Replication by Chloroplast and Mitochondrion." In Cyanidioschyzon merolae. Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-6101-1_13.

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Atti di convegni sul tema "Mitochondrial DNA replication"

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Silva, Ana Marina Dutra Ferreira da, Igor Dias Brockhausen, Alessandra Lima Nogueira Tolentino, Ana Laura Moura, and Alzira Alves de Siqueira Carvalho. "A467T variant of the polg gene: description of two clinical cases." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.669.

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Abstract (sommario):
Introduction: Variations in the POLG gene are the most common causes of mitochondrial disease of autosomal inheritance, and may be present in about 2% of the population. Case report: Case 1. CMAM, male, 48-year-old, complaining of bilateral eyelid ptosis with onset in adolescence. Since the age of six, he has been diagnosed with epilepsy. After five years of follow-up, he developed sensory ataxia. After 10 years he began to present dysarthria, dysphagia, tremor and pyramidal syndrome. Case 2. ASB, female, 42 years old, at 20 years old presented generalized clonic tonic crisis during the second
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