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Tesi sul tema "Microcystin"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Zilliges, Yvonne. "Molekulare Funktionsanalyse von Microcystin in Microcystis aeruginosa PCC 7806." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2008. http://dx.doi.org/10.18452/15782.

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Microcystine sind die wohl bekanntesten cyanobakteriellen Toxine. Sie werden im Wesentlichen durch die im Süßwasser weltweit verbreitete, koloniebildende Gattung Microcystis synthetisiert. Die biologische Funktion dieser Peptide ist jedoch ungeklärt. In dieser Studie wurde die Fragestellung erstmals über einen globalen Ansatz auf molekularer Ebene analysiert. Die proteomischen Analysen zwischen M. aeruginosa PCC 7806/ Wildtyp und einigen Microcystin-freien Mutanten deuten auf eine physiologische Rolle der Microcystine. Microcystine beeinflussen die Abundanz zahlreicher Proteine. Prominentester

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2

Phelan, Richard Reginald. "Microcystin enhances the fitness of microcystin producing cyanobacteria at high light intensities by either preventing or retarding photoinhibition." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/d1020957.

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Several genera of cyanobacteria produce microcystin, a monocyclic peptide, with a unique chemical structure. To date, there have been over a 100 different structural variants of microcystin which have been identified. Microcystin production is affected by numerous environmental factors. However, the primary modulating factor for intracellular microcystin quota is the intracellular N:C ratio. No clearly defined biological role has been described for microcystin. Proposed roles for microcystin include defence against plankton grazers, metal chelation, an infochemical and a protectant against oxi

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3

Phelan, Richard Reginald. "A potential biological role for microcystin in photosynthesis in Microcystis Aeruginosa." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/1285.

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Neither the ecological role nor the metabolic function of microcystin is known. Cellular microcystin concentrations correlate to cellular nitrogen status for a given environmental phosphorous concentration and specific growth rate. Microcystin production is enhanced when the rate of nitrogen accumulation exceeds the relative specific growth rate and/or when cellular N:C ratios exceed the Redfield ratio as a function of reduced carbon fixation, suggesting enhanced production of microcystin under carbon stress. Additionally, a strong correlation between medium phosphate and carbon fixation, and

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4

Downing, T. G. "The role of nitrogen in the regulation of microcystin content in Microcystis aeruginosa." Thesis, Stellenbosch : Stellenbosch University, 2005. http://hdl.handle.net/10019.1/50523.

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Thesis (PhD)--University of Stellenbosch, 2005.<br>ENGLISH ABSTRACT: Several genera of cyanobacteria produce a range of toxins. The increased rate of eutrophication of surface fresh waters due to anthropogenic inputs has resulted in more frequent and severe cyanobacterial bloom events. Such bloom events make impoundments unsuitable for recreational use and increase the cost of production of potable water due to the necessity for removal of toxins released from cells during the purification process. Microcystis aeruginosa is the major freshwater bloom-forming toxic cyanobacterium. Conce

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5

Sember, Craig Stewart. "The effect of nutrient levels and ratios on the growth of Microcystis aeruginosa and microcystin production." Thesis, University of Port Elizabeth, 2002. http://hdl.handle.net/10948/287.

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This study reports the findings on the effect of nitrates and phosphates on the biomass and toxin production of various strains of the unicellular non-nitrogen fixing cyanobacterium, Microcystis aeruginosa. The occurrence of blooms of Microcystis aeruginosa and microcystin in freshwater impoundments across the globe has been on the increase lately due to increased levels of eutrophication, resulting in human and animal deaths and illness, as well as drinking and recreational water foulment. A range of environmental factors have been shown to effect growth and microcystin production. Existing l

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6

Delaney, James M. "The biological activity of microcystin-LR, isolated from the cyanobacterium Microcystis aeruginosa against insects." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308015.

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7

Zemskov, Ivan [Verfasser]. "Total Synthesis of Microcystin-LR, Microcystin-LF, and Unnatural Derivatives thereof / Ivan Zemskov." Konstanz : Bibliothek der Universität Konstanz, 2016. http://d-nb.info/1169046711/34.

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8

Meissner, Sven Verfasser], and Elke [Akademischer Betreuer] [Dittmann. "Implications of Microcystin Production in Microcystis aeruginosa PCC 7806 / Sven Meissner ; Betreuer: Elke Dittmann-Thünemann." Potsdam : Universität Potsdam, 2015. http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-75199.

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9

Meissner, Sven [Verfasser], and Elke [Akademischer Betreuer] Dittmann-Thünemann. "Implications of Microcystin Production in Microcystis aeruginosa PCC 7806 / Sven Meissner ; Betreuer: Elke Dittmann-Thünemann." Potsdam : Universität Potsdam, 2015. http://d-nb.info/1218398965/34.

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10

Velkme, Erik. "A novel method for antisense oligonucleotide gene expression manipulation in toxigenic cyanobacterial species, Microcystis aeruginosa." OpenSIUC, 2020. https://opensiuc.lib.siu.edu/theses/2781.

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Abstract (sommario):

Algal blooms caused by toxigenic cyanobacterial species are an increasing economic burden globally, as high anthropogenic inputs of nitrogen and phosphorous, coupled with rising levels of atmospheric CO2, promote eutrophication and enhance bloom proliferation. Of the freshwater bloom forming species, Microcystis aeruginosa has garnered the most attention due to the production of toxic secondary metabolites known as microcystins. These cyclic peptides are potent eukaryotic protein phosphatase 1 and 2A inhibitors, and can induce hepatic damage if concentration levels reach above the World Health

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11

Woller-Skar, M. Megan. "Zebra Mussel (Dreissena Polymorpha) Promotion of Cyanobacteria in Low-Nutrient Lakes and the Subsequent Production and Fate of Microcystin." Bowling Green State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1256928121.

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12

Ha, Joo Hyun. "A study on characteristics of microcystin-producing cyanobacterial bloom and microcystin production using real-time PCR." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/124526.

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13

Drever, Matthew. "Generating microcystin antibodies by phage display." Thesis, University of Aberdeen, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445137.

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Abstract (sommario):

A naïve human antibody fragment phage display library was screened against conjugated microcystin-LR (MCLR). Phage antibodies were eluted with free MCLR to promote the isolation of free antigen binders. Isolated antibody fragments were cloned into a soluble expression vector and single-chain antibody (scAb) expressed in a bacterial host. All scAbs bound free antigen in an indirect competition ELISA and levels of sensitivity were determined. The most responsive clone 3A8 had an 800-fold increase in sensitivity to MCLR than previously documented scAbs and was able to detect levels below guid

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14

Qiao, Qin. "Reprotoxic effects of microcystins and secondary metabolites produced by cyanobacteria Microcystis in adult medaka fish." Thesis, Paris, Muséum national d'histoire naturelle, 2016. http://www.theses.fr/2016MNHN0022/document.

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Abstract (sommario):

Les efflorescences de cyanobactéries sont susceptibles d’avoir des effets néfastes sur les organismes des écosystèmes aquatiques, ainsi que sur les populations environnantes, notamment à travers la production de nombreuses molécules potentiellement toxiques (appelées cyanotoxines). Jusqu'à présent, une des cyanotoxines les plus étudiées est la microcystine (MC). Cette thèse a pour objectif d’évaluer la toxicité potentielle sur la reproduction de la MC-LR et de l'extrait d'une souche de Microcystis productrice de MCs en étudiant leurs effets toxiques sur le foie et les gonades de poissons medak

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15

Kehr, Jan-Christoph. "Characterisation of the lectin microvirin from Microcystis aeruginosa PCC 7806 and new insights into the role of microcystin." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15994.

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Sowohl in Süßwasserseen als auch in marinen Gewässern kommt es immer wieder zu Massenentwicklungen von Cyanobakterien, sogenannten “Blüten”. In Seen werden diese oftmals von Cyanobakterien der Gattung Microcystis dominiert, deren Arten häufig Toxine bilden. Die verbreitesten dieser Toxine sind die leberschädigen Microcystine, die eine Klasse nichtribosomal synthetisierter Peptide darstellen. Nachdem die toxische Wirkung der Microcystine bisher als deren Hauptfunktion angesehen wurde, deuten neuere Forschungsergebnisse darauf hin, dass Microcystine eine andere Primärfunktion für die Produzenten

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16

Racine, Marianne. "Metabolic Variation in the Toxigenic Cyanobacterium Microcystis Aeruginosa." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37718.

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Abstract (sommario):

Cyanobacteria are notorious for their potential to produce toxins with human health effects, particularly the hepatotoxic microcystins (MCs), but cyanobacteria also produce other bioactive compounds. A wide variety of oligopeptides including aeruginosins, cyanopeptolins and cyanobactins may be as toxic as MCs. To investigate the production of these compounds, an UPLC QTOF-MS/MS method was developed to compare the metabolomic profiles of various strains of a common bloom-forming and toxigenic species, Microcystis aeruginosa, as well as those obtained from lakes with mixed cyanobacterial assembl

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17

Humpage, Andrew Raymond. "Tumour promotion by the cyanobacterial toxin microcystin /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phh9258.pdf.

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18

Waack, Julia. "Uptake and depuration of cyanotoxins in the common blue mussel Mytilus edulis." Thesis, Robert Gordon University, 2017. http://hdl.handle.net/10059/2447.

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Abstract (sommario):

Cyanobacteria produce a variety of secondary metabolites which possess amongst others antifungal, antibacterial, and antiviral properties. Being primary producers they are also a vital component within the food web. However, certain strains also produce toxic metabolites such as the hepatotoxins microcystin (MC) and nodularin (NOD). Their toxicity in combination with the increasing global occurrence has resulted in a drinking water guideline limit of 1 μg L-1 being issued by the World Health Organisation (WHO). However, these toxins are not only present in water, but can be accumulated by fish

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19

Marshall, Randall S. "Environmental Isolations, Community Nutrient Ratio Effects, and Allelopathy of Microcystis from Grand Lake Saint Mary's." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397735879.

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20

Davenport, Emily J. "Diel regulation of metabolic functions of a western Lake Erie Microcystis bloom informed by metatranscriptomic analysis." Bowling Green State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1479477147782031.

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21

Arif, Abdul Rahman Thaslim. "An investigation on the effects of cyanopeptides on the growth and secondary metabolite production of Microcystis aeruginosa PCC7806." Thesis, Robert Gordon University, 2016. http://hdl.handle.net/10059/1582.

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Abstract (sommario):

Cyanobacteria are one of the oldest forms of photosynthetic life and may have contributed significantly to the evolution of oxygen into the then anoxic environment. Cyanobacteria are also one of the best sources of natural secondary metabolites (cyanopeptides) some of which have harmful effects on the ecosystem, while others may be beneficial. It is known that these secondary metabolites are continuously produced during growth, however, it is not known whether the producing cyanobacteria actually benefit from these metabolites. The overarching aim of this study was to answer the question ‘Why

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22

Borges, Renata Maria Cortez. "Identificação e quantificação de microcistinas por HPLC em reservatórios de água." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/97/97131/tde-24102012-125936/.

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A oferta de água vem se tornando cada vez mais diminuta à medida que a população, a indústria e a agricultura se expandem. A contaminação dos mananciais gerada pelo descarte de efluentes domésticos e industriais leva a eutrofização, processo pela qual grande aporte de nutrientes, particularmente fosfatos, leva ao crescimento excessivo de algas. As cianobactérias são microrganismos procariontes, que vivem nos ambientes mais adversos. A floração dessas algas quando presente em mananciais destinados ao consumo humano gera sérios problemas à saúde humana, pois algumas dessas algas podem gerar toxi

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23

Root, Hannah Patricia Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Transcription regulation of hepatotoxins microcystin and nodularin from cyanobacteria." Publisher:University of New South Wales. Biotechnology & Biomolecular Sciences, 2008. http://handle.unsw.edu.au/1959.4/43351.

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The role and function of hepatotoxins microcystin and nodularin produced by M.aeruginosa PCC 7806 and N. spumigena NSORlO respectively have yet to be elucidated. The mode of transcriptional regulation of these toxins, incorporating DNA binding proteins, was investigated, as an attempt to further understand the key control mechanisms acting on the toxins. The DNA binding proteins that control nitrogen and iron responsive transcription, NtcA and Fur, were identified from M. aeruginosa PCC7806 and N. spumigena NSOR10. Cloning and over-expression in E. coli was followed by mobility shift assays to

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24

Cross, David Michael. "Analytical methods for cyanobacterial toxins." Thesis, University of Bath, 1997. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390310.

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25

Reitz, Laura A. "Quantification of Microcystin Production and Loss Rates for the Spatiotemporal Distribution of Microcystis aeruginosa Blooms in Lake Erie." Bowling Green State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1594907425606966.

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26

Campbell, Dennis Leslie. "Laboratory and field investigations into the cyanobacterial hepatotoxin, microcystin-LR." Thesis, University of Dundee, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388382.

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27

Huang, Yuzhou. "Evaluating the Removal of Microcystin Variants with Powdered Activated Carbon." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1593536125422238.

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28

Graham, Jennifer L. "Environmental factors influencing microcystin distribution and concentration in Midwestern lakes /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3137703.

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29

Downs, Kerry. "The effect of selenium in the detoxification of the microcystin hepatotoxins." Thesis, University of Port Elizabeth, 2002. http://hdl.handle.net/10948/284.

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Abstract (sommario):

Blooms of cyanobacteria have been known to cause illness in humans and death in wild and domestic animals. One of the toxins produced by cyanobacteria is microcystin, which is a potent hepatotoxin. Microcystin is taken up by bile acid transporters in the intestine and transported into the liver. After exposure to acute doses of microcystin, severe haemorrhage has been observed along with apoptotic and necrotic hepatocytes. The cytoskeletal structure of the hepatocytes is disrupted and oxidative stress is induced. Selenium, a known anti-oxidant, has been shown to induce increased activity of gl

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30

Zastepa, Arthur. "Fate and Persistence of Microcystin Congeners in Lakes and Lake Sediments." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30453.

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Cyanobacterial blooms and their toxins are a major water quality and potential health risk around the world. This thesis developed an analytical method for microcystin congeners in sediments in order to examine their fate in lakes and establish the history of toxin-producing cyanobacteria in relation to environmental change using lake sediments. A novel method for both intra- and extracellular microcystins in lake sediments was developed, consisting of accelerated solvent extraction, hydrophilic-lipophilic balance solid phase extraction and multiple reaction monitoring-based HPLC-MS/MS quantit

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31

Su, Robin. "Microcystin-LR (MC-LR) Toxicity In The Gut-Liver Signaling Axis." University of Toledo Health Science Campus / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=mco1588673649090272.

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32

Villars, Kathryn E. Villars. "Removal of Microcystin-LR from Drinking Water Using Granular Activated Carbon." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1532007603377473.

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33

Cornish, Benjamin J. P. A. "The destruction of the cyanobacterial toxin microcystin-LR by semiconductor photocatalysis." Thesis, Robert Gordon University, 2000. http://hdl.handle.net/10059/3094.

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Abstract (sommario):

In fresh waters where cyanobacteria (blue-green algae) flourish, dense growths known as blooms occur. Such blooms present a threat to human and animal health as many of these cyanobacteria produce toxins. One such group of toxins are the microcystins which are hepatotoxic resulting in haemoraging and tumour promotion in the liver. There have been several reports of human poisonings resulting from the presence of cyanotoxins in potable waters, some of which have resulted in fatalities. The most frequently cited cyanotoxin in these poisonings has been microcystin-LR, which has prompted the World

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34

Jagani, Neelam V. "Evaluating Home Point-of-Use Reverse Osmosis Membrane Systems for Removal of Cyanotoxins." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1524844338053604.

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35

Zheng, Bingxue. "Quantitative Analysis and Determination of Microcystin in water by Capillary Electrophoresis Mass Spectrometry." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1538.

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Abstract (sommario):

The presence of harmful algal blooms (HAB) is a growing concern in aquatic environments. Among HAB organisms, cyanobacteria are of special concern because they have been reported worldwide to cause environmental and human health problem through contamination of drinking water. Although several analytical approaches have been applied to monitoring cyanobacteria toxins, conventional methods are costly and time-consuming so that analyses take weeks for field sampling and subsequent lab analysis. Capillary electrophoresis (CE) becomes a particularly suitable analytical separation method that can c

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36

Lee, Jung Ju. "Removal of Microcystin-LR from Drinking Water Using Adsorption and Membrane Processes." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1229026536.

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37

DeMarco, Jonathan R. "Cyanobacterial Blooms in Chautauqua Lake, NY: Nutrient Sources and Toxin Analyses." Bowling Green State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1625052848648708.

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38

Ross, Catherine M. "The Feasibility of Applying an Industrial Hygiene Sampling Method to Measure Airborne Microcystin." University of Toledo / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1513365627637454.

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39

Haase, Maxwell D. "Effects of the Algal Toxin Microcystin on Fishes in the James River, Virginia." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3941.

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Abstract (sommario):

With the global rise in frequency of harmful algal blooms in estuarine environments comes an increase in prevalence of toxic metabolites, such as microcystin (MC), that some of the cyanobacteria involved will produce. At high concentrations, MC may accumulate in consumer tissues and have deleterious effects on organisms; however impacts of the toxin on aquatic living resources at ecologically relevant concentrations have not been widely documented. We analyzed the effects of MC on juveniles of five fish species from the James River, Virginia to determine if MC has the potential to impede growt

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40

Alambo, Katherine I. "Cyanobacteria North of 60°: Environmental DNA Approaches." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35665.

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Cyanobacterial blooms, such as those recently reported in Great Slave Lake (GSL, NWT), have sparked concern over the occurrence of toxic blooms in the North. This study investigated past and present incidences of cyanobacteria in lakes above latitude 60° N. The abundance of the toxin (microcystin) gene mcyE, as well as genes common to all cyanobacteria (16S rRNA) and bacteria (glnA) were quantified from lake sediment cores using ddPCR. Individual colony isolates from a surface bloom in Yellowknife Bay (GSL) in August 2015 were amplified and identified as non-toxigenic Dolichospermum lemmermann

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41

Bury, Nicolas R. "The effects of cyanobacteria on fish." Thesis, University of Dundee, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367494.

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42

Ji, Bo. "Effects of environmental factors on the growth and microcystins production of Microcystis aeruginosa." HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/670.

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43

Halvorson, Rebecca Ann. "Raman Spectroscopy for Monitoring of Microcystins in Water." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/76924.

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Abstract (sommario):

Cyanobacterial blooms are of great concern to the drinking water treatment industry due to their capacity to produce microcystins and other cyanotoxins that are deadly to humans, livestock, pets, and aquatic life at low doses. Unfortunately, the strategies currently employed for cyanotoxin detection involve laborious analyses requiring significant expertise or bioassay kits that are subject to numerous false positives and negatives. These methods are incapable of providing rapid, inexpensive, and robust information to differentiate between the >80 cyanotoxin variants potentially present in an

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44

Júlio, Maria de Fátima de Jesus Leal. "Carbon key-properties for microcystin adsorption in drinking water treatment: structure or surface chemistry?" Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/7066.

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Dissertação para Obtenção de Grau de Mestre em Engenharia Química e Bioquímica<br>The carbon key-properties (structure and surface chemistry) for microcystin-LR (MC-LR) adsorption onto activated carbon were investigated. Waters with an inorganic background matrix approaching that of the soft natural water (2.5 mM ionic strength) were used. Also, model waters with controlled ionic make-up and NOM surrogate with similar size of MC-LR (tannic acid - TA) with MC-LR extracts were tested with activated carbon NORIT 0.8 SUPRA. For this AC, two particle sizes, 125-180 μm and 63-90 μm were tested. The

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45

Thees, Alison. "Identification and Characterization of Lake Erie Bacteria that Degrade the Microcystin Toxin MC-LR." University of Toledo Health Science Campus / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=mco15254429474901.

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46

Ihle, Tilo. "Die raum-zeitliche Variation von Microcystis spp. (Cyanophyceae) und Microcystinen in der Talsperre Quitzdorf (Sachsen)." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1214480543195-41264.

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Abstract (sommario):

Cyanobakterien bilden zahlreiche bioaktive Substanzen mit zum Teil humantoxischer Relevanz. Nicht selten spielen dabei zyklische Peptide, zu denen unter anderem die Microcystine (MCYST) gehören, eine Schlüsselrolle. MCYST werden u.a. von Microcystis KÜTZING EX LEMMERMANN 1907 gebildet. Erkenntnisse zur ökophysiologischen Funktion der MCYST, die zweifelsfrei bei den Produzenten selbst zu suchen ist, liegen bisher kaum vor. Mit Hilfe von Freilanduntersuchungen sollten im Rahmen der vorliegenden Arbeit Kenntnisse zu einer möglichen ökologischen Funktion der MCYST erweitert und vertieft werden. Gr

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47

Bortoli, Stella de. "Investigação da biossíntese de toxinas produzidas por cepas de cianobactérias." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-29092011-164054/.

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Abstract (sommario):

A demanda crescente de água doce de boa qualidade são problemas atuais e mundiais, além do descaso com os dejetos lançados nos ambientes aquáticos que comprometem a qualidade dos recursos hídricos. Um dos parâmetros que atesta a potabilidade da água é a presença de cianobactérias e cianotoxinas. Cianobactérias são microrganismos procariontes aeróbicos fotoautróficos que sintetizam as cianotoxinas. Estes compostos podem ser classificados de acordo com seus mecanismos de ação em hepatotóxicos, neurotóxicos e dermatotóxicos. Por sua diversidade, representam diferentes riscos não só ao ecossistema

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48

Krishnan, Anjali. "ASSESSMENT OF BIODEGRADATION AND TOXICOLOGICAL EFFECTS OF MICROCYSTINS." Kent State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=kent1560600592119155.

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49

Stanic, Dina. "Characterization of Oscillatoria spp. and their Role in Black Band Disease of Coral." FIU Digital Commons, 2010. http://digitalcommons.fiu.edu/etd/243.

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Abstract (sommario):

Black band disease (BBD) is a cyanobacterial dominated pathogenic consortium that affects corals worldwide. Recently two cyanobacteria (Oscillatoria strains 101-1 and 100-1) were isolated into culture from BBD. The aim of this study was to characterize the strains and assess their role in BBD pathogenesis. Light, scanning electron and transmission electron microscopy, coupled with 16S rRNA gene sequencing, were used for taxonomic characterization. Cyanotoxin production was assessed by enzyme-linked immunosorbent assay. Toxin identification was performed by high performance liquid chromatograph

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50

Chianella, Iva. "Development of affinity sensors for Microcystin-LR based on a computationally designed molecularly imprinted polymer." Thesis, Cranfield University, 2003. http://dspace.lib.cranfield.ac.uk/handle/1826/10744.

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In this work the development of affinity sensors for the detection of microcystin-LR based on a computationally designed artificial receptor is presented. Microcystin-LR is a cyclic heptapeptide hepatotoxin produced by Cyanobacteria (aquatic organisms also known as blue-green algae), which during blooms period can release toxins in water. Clinical signs of hepatotoxicosis have been observed in domestic animals and livestock and recently also in humans. At present, analysis of these toxins is achieved largely using conventional, time consuming and expensive techniques such as chromatographic me

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