Bibliografie tematiche / Metabolic Skin Diseases

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Letteratura scientifica selezionata sul tema "Metabolic Skin Diseases"

Autore: Grafiati
Pubblicato: 29 luglio 2024
Ultima modifica: 31 luglio 2024

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Articoli di riviste sul tema "Metabolic Skin Diseases"

1

Ünlü, Begüm, e Ümit Türsen. "Autoimmune skin diseases and the metabolic syndrome". Clinics in Dermatology 36, n. 1 (gennaio 2018): 67–71. http://dx.doi.org/10.1016/j.clindermatol.2017.09.012.

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2

Muinovna, Khamidova Farida. "MORPHOGENETIC CHARACTERISTICS OF KERATODERMA IN METABOLIC DISORDERS". American Journal Of Biomedical Science & Pharmaceutical Innovation 4, n. 6 (1 giugno 2024): 54–69. http://dx.doi.org/10.37547/ajbspi/volume04issue06-09.

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Abstract (sommario):
Studying the morphological and genetic different types of keratoses is key for correct diagnosis and choice of treatment. The association between metabolic disorders and skin diseases highlights the need for an integrated approach to the management of patients with chronic diseases, including diabetes mellitus. Further research is needed to better understand the pathogenesis and develop effective treatments.
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Urrets-Zavalía, Julio A., Evangelina Espósito, Iliana Garay, Rodolfo Monti, Alejandro Ruiz-Lascano, Leandro Correa, Horacio M. Serra e Andrzej Grzybowski. "The eye and the skin in endocrine metabolic diseases". Clinics in Dermatology 34, n. 2 (marzo 2016): 151–65. http://dx.doi.org/10.1016/j.clindermatol.2015.12.001.

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Napolitano, Maddalena, Matteo Megna e Giuseppe Monfrecola. "Insulin Resistance and Skin Diseases". Scientific World Journal 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/479354.

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Abstract (sommario):
In medical practice, almost every clinician may encounter patients with skin disease. However, it is not always easy for physicians of all specialties to face the daily task of determining the nature and clinical implication of dermatologic manifestations. Are they confined to the skin, representing a pure dermatologic event? Or are they also markers of internal conditions relating to the patient’s overall health? In this review, we will discuss the principal cutaneous conditions which have been linked to metabolic alterations. Particularly, since insulin has an important role in homeostasis and physiology of the skin, we will focus on the relationships between insulin resistance (IR) and skin diseases, analyzing strongly IR-associated conditions such as acanthosis nigricans, acne, and psoriasis, without neglecting emerging and potential scenarios as the ones represented by hidradenitis suppurativa, androgenetic alopecia, and hirsutism.
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Sirufo, Maria Maddalena, Francesca De Pietro, Enrica Maria Bassino, Lia Ginaldi e Massimo De Martinis. "Osteoporosis in Skin Diseases". International Journal of Molecular Sciences 21, n. 13 (3 luglio 2020): 4749. http://dx.doi.org/10.3390/ijms21134749.

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Abstract (sommario):
Osteoporosis (OP) is defined as a generalized skeletal disease characterized by low bone mass and an alteration of the microarchitecture that lead to an increase in bone fragility and, therefore, an increased risk of fractures. It must be considered today as a true public health problem and the most widespread metabolic bone disease that affects more than 200 million people worldwide. Under physiological conditions, there is a balance between bone formation and bone resorption necessary for skeletal homeostasis. In pathological situations, this balance is altered in favor of osteoclast (OC)-mediated bone resorption. During chronic inflammation, the balance between bone formation and bone resorption may be considerably affected, contributing to a net prevalence of osteoclastogenesis. Skin diseases are the fourth cause of human disease in the world, affecting approximately one third of the world’s population with a prevalence in elderly men. Inflammation and the various associated cytokine patterns are the basis of both osteoporosis and most skin pathologies. Moreover, dermatological patients also undergo local or systemic treatments with glucocorticoids and immunosuppressants that could increase the risk of osteoporosis. Therefore, particular attention should be paid to bone health in these patients. The purpose of the present review is to take stock of the knowledge in this still quite unexplored field, despite the frequency of such conditions in clinical practice.
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Pozdnyakova, O. N., O. B. Nemchaninova, S. G. Lykova e T. B. Reshetnikova. "Clinical features of «metabolism» diseases of the skin in patients with chronic diffuse liver diseases". Terapevticheskii arkhiv 89, n. 1 (15 gennaio 2017): 49–52. http://dx.doi.org/10.17116/terarkh201789149-52.

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Aim. To determine the clinical features of skin diseases developing in the presence of metabolic disturbances in patients with chronic diffuse liver diseases. Subjects and methods. A total of 368 patients with different clinical forms of hepatopathy were comprehensively examined. Results. 817 cases of seborrhea, skin itch, xerodermia, xanthomatosis, and dyschromia were detected in 318 (86.4%) patients. Conclusion. The prevalence and intensity of cutaneous manifestations depended on the nature of the pathological liver process and indirectly testified to its severity and activity. The symptoms of skin diseases were most pronounced in patients with autoimmune liver lesions, chronic toxic hepatitis, and cirrhosis.
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Furue, Masutaka, Gaku Tsuji, Takahito Chiba e Takafumi Kadono. "Cardiovascular and Metabolic Diseases Comorbid with Psoriasis: Beyond the Skin". Internal Medicine 56, n. 13 (2017): 1613–19. http://dx.doi.org/10.2169/internalmedicine.56.8209.

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Bakalets, N. F., e L. A. Poroshina. "Metabolic Syndrome as a Risk Factor for Skin Pathology". Health and Ecology Issues, n. 4 (28 dicembre 2018): 9–15. http://dx.doi.org/10.51523/2708-6011.2018-15-4-2.

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Wierzcholski, Krzysztof. "The Metabolic Process After Lubrication of Human Joint and Skin Surfaces". Clinical Research Notes 3, n. 3 (30 aprile 2022): 01–11. http://dx.doi.org/10.31579/2690-8816/058.

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Purpose The topic of the presented paper concerns the human body and joint cartilage run-walk treatment implemented by the Electro-Magnetic (EM) and Acoustic Emission (AE) field. The thesis is proved here i.e. running in presence of a EM and AE field, increases dynamic viscosity of bio-lubricant liquids, thus increases energy burn, metabolism and finally it leads to the decrements of the body weight and hence it accelerates the slimming process. Material and Methods The research methods used in this paper include the following: EM field produced by a new Polish Apparatus MF-24, MT-3, Germany Magcell Arthro magneto electronic devices for the human body and joint cartilage treatment, Bone Dias Apparatus applied in AE therapy produced in Germany, ( Univ. Applied Science Giessen), Segmental Body Composition Analyzer Tanita MC 780MA, pedometer Garmin Ltd.2015.The author gained experience in Germany research institutes, and practical results were obtained after measurements and information from students and patients. Results The EM-therapy and AE results presented in this paper concern betterments during typical human cartilage diseases and causes of the effects of the slimming process gained before and after run-walk training. The run-walk training results presented in this paper concern the effects of the slimming process gained without and after electro-magnetic field therapy. Conclusions The main conclusions obtained in this paper are as follows: The run-walk training implemented by the electro-magnetic induction field and AE leads to the increments of the dynamic viscosity of synovial fluid and human sweat, changes the internal energy contained in the human body, muscle and cartilage, hence it accelerates the slimming process connected with the body weight decrements as well the betterments effects during the therapy.
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Curtis, Ashley R. "Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional, and Deposition Diseases". American Journal of Dermatopathology 33, n. 2 (aprile 2011): 203. http://dx.doi.org/10.1097/dad.0b013e31820e34f0.

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Più fonti

Tesi sul tema "Metabolic Skin Diseases"

1

[Verfasser], Marthoenis. "Metabolic syndrome and skin diseases among psychiatric inpatients in Aceh - Indonesia / Marthoenis". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1100388397/34.

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McAdler, Marisa M. "The Relationship Between Vitamin D Status of Adult Women and Diet, Sun Exposure, Skin Reflectance, Body Composition, and Insulin Sensitivity". DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/1090.

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Abstract (sommario):
As the prevalence of vitamin D deficiency continues to grow, mounting evidence supporting its link with chronic disease strengthens suggesting vitamin D’s candidacy in the prevention and treatment of multiple disease states and their complications. Dietary guidelines, however, do not take sun exposure into account. The present study sought to explore the impact of sun exposure on vitamin D status (serum 25(OH)D), and identify other significant determinants of serum levels which may have the greatest effects on overall health. Participants (n = 34) were pre-menopausal women aged 18 to 50 years (mean age 39 ± 6 years), who had their blood drawn at a local pathology lab and a follow-up appointment at a health assessment lab for the collection of other measurements. Mean serum 25(OH)D level was 64 ± 18 nmol/L, and mean dietary vitamin D intake was approximately 327 ± 229 IU/day. Although 82% of participants were below the RDA guidelines (600 IU/day for females ages 9-50 years) for dietary vitamin D intake, only 32% had serum 25(OH)D levels < 50 nmol/L (the recommended level of sufficiency for bone health) reflecting deficiency. While serum 25(OH)D levels were significantly correlated to dietary vitamin D intake (r = 0.42, p = 0.0139), it is reasonable to assume that participants obtained adequate vitamin D from sun exposure. Fasting serum insulin levels were significantly, positively correlated with BMI (r = 0.83, p < 0.0001), and sun exposure index (Body Surface Area x Minutes of Direct Sunlight) was significantly, positively correlated with serum 25(OH)D levels (fall weekend SEI: r = 0.47, p = 0.0059; spring weekend SEI: r = 0.43, p = 0.0135; average weekend SEI: r = 0.43, p = 0.013; and average overall SEI: r = 0.39, p = 0.0247). Reported sun exposure appeared to be least during winter weekdays and the most during summer weekends. Regression analysis was used to determine the strongest predictors of serum 25(OH)D levels, which were found to be sun exposure, dietary vitamin D intake, skin reflectance, age, BMI, and ethnicity (R2 = 0.58 , p = 0.0031), demonstrating that simple questionnaires, such as those employed in this study, can help to predict serum 25(OH)D status and thus be considered in the future treatment of vitamin D deficiency.
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Wang, Elaine. "Warburg or reverse Warburg effect: Tumor microenvironment reprograms breast cancer metabolism to upregulate cell proliferation". Scholarship @ Claremont, 2018. http://scholarship.claremont.edu/cmc_theses/1966.

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Abstract (sommario):
Cancer cells are most clearly characterized by their abnormal and uncontrolled cell growth. One of the most notable theories that explains the vast proliferative capacity of tumorigenic cells is the Warburg effect, a significant shift in metabolism wherein cancer cells preferentially fuel cell division using aerobic glycolysis instead of aerobic respiration. This upregulation of glycolytic fermentation in aerobic environments is highly unusual - glycolysis is typically utilized in anaerobic conditions, but nonetheless dominates cancer metabolic activity in spite of the presence of oxygen. Since the discovery the Warburg effect in the 1920s, researchers have struggled to identify whether aerobic glycolysis is a cause or consequence of carcinogenesis. Interestingly, a new theory recently emerged that challenges this widely-accepted metabolic paradigm for cancer. Known as the reverse Warburg effect, this new mechanism shows that in carcinomas such as breast cancer, the Warburg effect occurs not in cancer cells, but rather in tumor-adjacent stromal fibroblasts. These cancer-associated fibroblasts (CAFs) in the greater tumor microenvironment produce lactate - a high-energy metabolite formed as a byproduct of aerobic glycolysis - to fuel aerobic respiration and rapid tumorigenesis in neighboring cancer cells. This emerging theory emphasizes the pivotal role of the tumor microenvironment in determining whether cancer cells undergo aerobic glycolysis or aerobic respiration. Central to this lactate-linked metabolic intersection are two critical enzymes that regulate a cell's metabolic commitment - lactate dehydrogenase (LDH) and pyruvate dehydrogenase complex (PDHc). In order to clarify the mechanisms through which CAFs induce tumorigenesis in breast cancer, we plan to carry out two specific aims: (1) evaluate the enzymatic activity of LDH and PDHc, and (2) compare LDH and PDHc enzyme content. Using co-culture techniques to study the breast cancer tumor microenvironment in vitro, we will compare the enzymatic activity and enzyme content of both MCF7 breast cancer cells and CAFs to identify whether the reverse Warburg effect occurs due to post-translational enzyme activation or increased enzyme synthesis.
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Aouidet, Abdallah. "L'installation et le devenir de l'athérome chez le singe Cynomolgus (Macacus fascicularis) soumis à un régime hypercholestérolémique : étude des parois aortiques et coronariennes, des paramètres sériques et cutanés". Toulouse 3, 1987. http://www.theses.fr/1987TOU30237.

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Pavez, Loriè Elizabeth. "Retinoic Acid Metabolism Blocking Agents and the Skin : In vivo and in vitro Studies of the Effects on Normal and Diseased Human Epidermis". Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9325.

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Retinoic Acid Metabolism Blocking Agents (RAMBAs) increase the endogenous levels of all-trans retinoic acid (RA) by inhibiting CYP26 enzymes. Thus they are believed to mimic the effects of retinoid treatment. Their mechanism of action and effects on vitamin A metabolism in keratinocytes are however uncertain. To explore this and the function of CYP26 in human skin was the main purpose of the project. The effects of two RAMBAs (talarozole and liarozole) on the expression of retinoid biomarkers in epidermis were studied in vivo and in vitro. Normal human skin (n=16) exposed to topical talarozole for 9 days showed similar response as previously reported for topical RA, even though no skin inflammation occurred. Lamellar ichthyosis patients (n=11) treated systemically with liarozole showed variable clinical improvement after 4 weeks with only mild effects on the retinoid biomarkers and the expression did not always correlate at the protein and mRNA levels. In these studies the proinflammatory transcripts IL-1α and TNFα were down-regulated by RAMBAs. In vitro, using an organotypic epidermis model we first studied how the RA metabolism was affected by adding RA and/or RAMBAs. We next examined the effects of the same agents on the expression of vitamin A metabolising enzymes in monolayer cultures of proliferating and differentiating keratinocytes. The results show among other things that CYP26 A1 and B1 are both involved in the catabolism of RA, and that talarozole potently increases the level of endogenous RA, primarily by inhibiting CYP26B1. However the drug´s biological effects cannot be solely attributed to increased RA levels. In conclusion, RAMBAs are promising new drugs for treatment of skin disorders, but further studies on their mechanism of action are needed.
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Smirni, Salvatore. "Nonlinear dynamics of microcirculation and energy metabolism for the prediction of cardiovascular risk". Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/c551cbef-6f00-48ef-b753-ad76ac93daf4.

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Abstract (sommario):
The peripheral skin microcirculation reflects the overall health status of the cardiovascular system and can be examined non-invasively by laser methods to assess early cardiovascular disease (CVD) risk factors, i.e. oxidative stress and endothelial dysfunction. Examples of methods used for this task are the laser Doppler flowmetry (LDF) and laser fluorescence spectroscopy (LFS), which respectively allow tracing blood flow and the amounts of the coenzyme NAD(P)H (nicotamide adenine dinucleotide) that is involved in the cellular production of ATP (adenosine triphosphate) energy. In this work, these methods were combined with iontophoresis and PORH (post-occlusive reactive hyperaemia) reactive tests to assess skin microvascular function and oxidative stress in mice and human subjects. The main focus of the research was exploring the nonlinear dynamics of skin LDF and NAD(P)H time series by processing the signals with the wavelet transform analysis. The study of nonlinear fluctuations of the microcirculation and cell energy metabolism allows detecting dynamic oscillators reflecting the activity of microvascular factors (i.e. endothelial cells, smooth muscle cells, sympathetic nerves) and specific patterns of mitochondrial or glycolytic ATP production. Monitoring these dynamic factors is powerful for the prediction of general vascular/metabolic health conditions, and can help the study of the mechanisms at the basis of the rhythmic fluctuations of micro-vessels diameter (vasomotion). In this thesis, the microvascular and metabolic dynamic biomarkers were characterised in-vivo in a mouse model affected by oxidative stress and a human cohort of smokers. Data comparison, respectively, with results from control mice and non-smokers, revealed significant differences suggesting the eligibility of these markers as predictors of risk associated with oxidative stress and smoke. Moreover, a relevant link between microvascular and metabolic oscillators was observed during vasomotion induced by α-adrenergic (in mice) or PORH (in humans) stimulations, suggesting a possible role of cellular Ca2+ oscillations of metabolic origin as drivers of vasomotion which is a theory poorly explored in literature. As future perspective, further exploration of these promising nonlinear biomarkers is required in the presence of risk factors different from smoke or oxidative stress and during vasomotion induced by stimuli different from PORH or α-adrenergic reactive challenges, to obtain a full picture on the use of these factors as predictors of risk and their role in the regulation of vasomotion.
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Rajaobelina, Kalina. "Autofluorescence cutanée des produits de glycation avancée (AGE), mémoire métabolique et complications du diabète". Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0256/document.

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Abstract (sommario):
Dans un contexte de vieillissement de la population et d’accroissement des maladies chroniques liées à l’âge comme le diabète, de nouveaux biomarqueurs de l’état de santé à long terme doivent être étudiés. Les produits de glycation avancée (AGE) sont des molécules témoins de la charge métabolique accumulée au cours du temps, dénommée "mémoire métabolique". Les AGE jouent un rôle important dans les lésions à long terme dans le diabète et dans le déclin du métabolisme global lié au vieillissement. L’accumulation cutanée des AGE peut être mesurée par autofluorescence (AF) de manière instantanée et non invasive grâce à l’AGE-READER. Les objectifs de cette thèse étaient d’évaluer la valeur de l’AF cutanée des AGE en tant que marqueur de mémoire métabolique chez des personnes âgées de la cohorte des 3-Cités et parallèlement d’évaluer la valeur pronostique de l’AF pour les complications du diabète chez des patients porteurs de diabète de type 1. Chez les personnes âgées, nous avons montré que l’AF reflétait les statuts glycémique et rénal 10 ans avant la mesure. Chez les patients atteints de diabète de type 1, l’AF était associée à la présence d’une neuropathie 4 ans plus tard. De plus, dans cette même population, nous avons décrit l’évolution de l’AF sur 4 ans de suivi. Nous avons montré que les principaux déterminants de son évolution étaient la fonction rénale et le traitement par pompe à insuline. Enfin nous avons trouvé que l’augmentation de l’AF sur 4 ans de suivi était associée à la survenue de la maladie rénale. Ces travaux soulèvent de nouvelles perspectives de recherche quant à l’intérêt de l’AF à différents âges clés de la vie en tant que biomarqueur de pathologies qui évoluent sur des dizaines d’années
In the context of the ageing of the population and the increase of age related diseases such as diabetes, new biomarquers of the long-term health status should be considered. Advanced glycation end products (AGE) are molecules indicators of the metabolic burden over time, called “metabolic memory”. AGE play an important role in long term diabetes injuries and in the global decline of the metabolism related to ageing. Skin accumulation of AGE can be measured by autofluorescence instantly and non-invasivly with a tool called AGE-READER. The objectives of my dissertation were to evaluate the value of the skin autofluorescence (sAF) of AGE as marker of metabolic memory in elderly people from the 3-City cohort and in parallel, in patients with type 1 diabetes, evaluate the prognostic value of sAF for diabetes complications. In the elderly population, we showed that sAF reflected glycemic and renal status of 10 years before. In patients with type 1 diabetes, sAF was associated to the presence of neuropathy 4 years later. Moreover, in this same population, we described the evolution of sAF in 4 years of follow-up and we showed that the principal determinants of the evolution of sAF were kidney function and insulin pump therapy. Finally, we also found that increase of sAF in 4 years was associated with the occurrence of kidney disease. This work rises new research opportunities about the interest of sAF at differents key ages as biomarker of pathologies which evolve in several decades
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Catherman, Colin M. "Short and Long Chain Free Fatty Acids Differentially Regulate Glucagon-like Peptide-1 and Peptide YY Transcript Levels in Enteroendocrine Cells (STC-1)". VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4797.

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Abstract (sommario):
The regulation of glucagon-like peptide-1 and peptide YY hormone levels are regulated based on different influential factors, but primarily levels are dependent upon ingested food content. As meals today become more fat-enriched, there is greater requirement for evaluation of these hormones that regulate insulin and satiety levels within the body. We have shown that the gene expression transcript production of glucagon-like peptide-1 and peptide YY are modulated by different concentrations, and times of short-chain fatty acids and long-chain fatty acids. Although the peptide hormone levels have the influential physiological role on effector tissue, the regulation of these hormones begins at the transcript levels. Recent research indicates that glucagon-like peptide-1 and peptide YY hormones are altered in response to different free-fatty acids. The present investigation generally demonstrated an overall decrease in both hormones after chronic exposure to fatty acids. Intestinal secretin tumor cell line (STC-1 cells) was used as a representative for intestinal L-cells. Quantitative real-time PCR analysis was used to determine the changes in RNA transcripts. Overall, there was a decrease in the 3-hour timeline, which continued to decrease in the 16-hour and 24-hour timelines for glucagon-like peptide-1. Peptide YY transcript expression in 3-hours increased significantly after exposure to propionate, a significant decrease after exposure to acetate, and no significant increase or decrease after exposure to butyrate. However, there was a significant decrease in peptide YY once reaching 24-hour exposure. It was determined there is a threshold for different concentrations of free-fatty acids to influence glucagon-like peptide-1 and peptide YY production, which was present in the different concentrations of butyrate. Lastly, exposure to both concentrations of linolenic acid caused a significant decrease in glucagon-like peptide-1 and peptide YY.
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Mardilovich, Katerina. "Insulin Receptor Substrate-2 (IRS-2): A Novel Hypoxia-Responsive Gene in Breast Cancer: A Dissertation". eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/533.

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Breast cancer is the most common malignancy among women in the U.S. While many successful treatments exist for primary breast cancer, very few are available for patients with metastatic disease. The purpose of this study was to understand the role of Insulin Receptor Subtrate-2 (IRS-2) in breast cancer metastasis. IRS-2 belongs to the IRS family of cytoplasmic adaptor proteins that mediate signaling from cell surface receptors, many of which have been implicated in cancer. Although the IRS proteins are highly homologous in structure and have some complementary functions, growing evidence supports that the IRS proteins have unique roles in cancer. IRS-1 has been shown to promote tumor cell proliferation, while IRS-2 has been positively associated with cancer cell invasion, glycolysis and tumor metastasis. In the current work, we identified IRS-2 as a novel hypoxia-responsive gene in breast carcinoma cells. In contrast, IRS-1 expression does not increase in response to hypoxia, supporting the notion of their non-overlapping functions. Hypoxia promotes the adaptation and resistance of cancer cells to chemo- and radiation therapy, and also promotes tumor cell survival, invasion and metastasis by selecting for aggressive tumor cells that can survive under stressful low oxygen conditions. We have shown that IRS-2 upregulation in response to hypoxia promotes Akt signaling and tumor cell viability and invasion. We identified a cell context-dependent role for Hypoxia Inducible Factor (HIF) in the regulation of IRS-2 expression in hypoxia, with HIF-2 playing a more dominant role than HIF-1. We also demonstrate that binding of Snail, a regulator of the EMT, to the IRS-2 promoter keeps the chromatin in an open conformation that is permissive for HIF-dependent transcription of IRS-2 in hypoxia. IRS-2 is not upregulated by hypoxia in well-differentiated epithelial-like carcinoma cells that do not express Snail, implicating IRS-2 gene expression as part of the EMT programming. In summary, we have identified an endogenous mechanism by which cancer cells can shift the balance of IRS-1 and IRS-2 to favor IRS-2 expression and function, which promotes survival, invasion, and ultimately metastasis. Understanding the mechanism of IRS-2 regulation by hypoxia may reveal new therapeutic targets for metastatic breast cancer.
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Wang, Zhixing. "Transcriptional regulation of mouse epidermal permeability barrier development and homeostasis by Ctip2". Thesis, 2012. http://hdl.handle.net/1957/31570.

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Abstract (sommario):
Skin is the largest organ in the body that protects the organism from environmental, chemical and physical traumas of each passing day. The protective skin epidermal permeability barrier (EPB) is formed within the exterior layers of the epidermis, which are regularly sloughed off and repopulated by movement of inner cells. The epidermal permeability barrier is established during in utero development and maintained through lifetime. Impaired epidermal barrier formation is one of the major features of several dermatoses such as psoriasis and atopic dermatitis. Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (Ctip2), also known as Bcl11b, is a C���H��� zinc finger protein expressed in many organs and tissues. It has been shown to regulate the development of thymocyte, tooth and corticospinal motor neurons. Ctip2 is highly expressed in mouse epidermis during skin organogenesis and in adulthood. It is crucial for epidermal homeostasis and protective barrier formation in developing mouse embryos. Germline (Ctip2- null mice) and selective ablation of Ctip2 in mouse epidermis (Ctip2[superscript ep-/-] mice) leads to increased transepidermal water loss (TEWL), impaired epidermal proliferation and terminal differentiation as well as altered lipid distribution during embryogenesis. Sphingolipids account for ~50% of total skin lipids by weight and are crucial components of epidermal barrier. We have recently identified Ctip2 as a key regulator of skin lipid metabolism. Germline deletion of Ctip2 in mouse embryos leads to altered lipid composition in the developing mouse epidermis by modulating the expression levels of key enzymes involved in lipid metabolism (bio-synthesis and catabolism). We also demonstrated that Ctip2 is recruited to the promoter regions of several genes involved in the ceramide and sphingomyelin biosynthesis pathways and could directly regulate their expression. Thus, we have identified Ctip2 as a key regulator of several lipid metabolizing genes and hence epidermal sphingolipid biosynthesis during skin development. To study the role of Ctip2 in adult skin homeostasis, we have utilized Ctip2[superscript ep-/-] mouse model in which Ctip2 is selectively deleted in epidermal keratinocytes. We showed that keratinocytic ablation of Ctip2 leads to atopic dermatitis (AD)-like skin inflammation, characterized by alopecia, pruritus and scaling, as well as high infiltration of T lymphocytes and immune cells. We have also observed increased expression of Th2-type cytokines and chemokines in the mutant skin, as well as systemic immune responses that share similarity with human AD patients. Furthermore, we discovered that thymic stromal lymphopoietin (TSLP) expression is significantly upregulated in the mutant epidermis as early as postnatal day 1 and Ctip2 was recruited to the promoter region of the TSLP gene in mouse epidermal keratinocytes. The results suggest that upregulation of TSLP expression in the Ctip2[superscript ep-/-] epidermis could be due to a derepression of gene transcription in absence of Ctip2. Thus, our data demonstrated a cell-autonomous role of Ctip2 in barrier maintenance and epidermal homeostasis in adult skin, as well as a non-cell autonomous role of keratinocytic Ctip2 in suppressing skin inflammatory responses by regulating the expression of Th2-type cytokines in adult mouse skin. Present results establish an initiating role of epidermal TSLP in AD pathogenesis via a novel repressive regulatory mechanism mediated by Ctip2 in mouse epidermal keratinocytes. Altogether, our study indicates that Ctip2 could be involved in a diverse range of biological events in skin including barrier formation, maintenance and epidermal homeostasis. Ctip2 appears to be a master regulator in skin barrier functions by directly regulating the transcription of a subset of genes involved in lipid metabolism and inflammatory responses.
Graduation date: 2013
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Libri sul tema "Metabolic Skin Diseases"

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J, Vermeer B., e European Society for Dermatological Research., a cura di. Metabolic disorders and nutrition correlated with skin. Basel: Karger, 1991.

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2

Smoller, Bruce R., e Franco Rongioletti, a cura di. Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-60761-181-3.

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1949-, Schröder Jens-Michael, a cura di. Fatty acids and inflammatory skin diseases. Basel: Birkhäuser Verlag, 1999.

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I, Maibach Howard, a cura di. Toxicology of skin. New York: Taylor & Francis, 2000.

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Fuchs, Jürgen. Oxidative injury in dermatopathology. Berlin: Springer-Verlag, 1992.

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Fuchs, Jürgen, 1957 June 28- e Packer Lester, a cura di. Oxidative stress in dermatology. New York: Dekker, 1993.

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Jenifer, Swanson, a cura di. Physical and mental issues in aging sourcebook: Basic consumer health information on physical and mental disorders associated with the aging process, including concerns about cardiovascular disease, pulmonary disease, oral health, digestive disorders, musculoskeletal and skin disorders, metabolic changes, sexual and reproductive issues, and changes in vision, hearing, and other senses; along with data about longevity and causes of death, information on acute and chronic pain, descriptions of mental concerns, a glossary of terms, and resource listings for additional help. Detroit, MI: Omnigraphics, 1999.

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Keith, Lierre. The vegetarian myth: Food, justice and sustainability. Crescent City, Ca: Flashpoint Press, 2009.

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Smoller, Bruce R., e Franco Rongioletti. Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease. Springer New York, 2016.

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Clinical And Pathological Aspects Of Skin Diseases In Endocrine Metabolic Nutritional And Deposition Disease. Springer, 2010.

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Capitoli di libri sul tema "Metabolic Skin Diseases"

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Martinelli, Diego, Maya El Hachem, Enrico Bertini e Carlo Dionisi-Vici. "Skin and Hair Disorders". In Inherited Metabolic Diseases, 341–70. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-49410-3_31.

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Dionisi-Vici, Carlo, May El Hachem e Enrico Bertini. "Skin and Hair Disorders". In Inherited Metabolic Diseases, 197–217. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-74723-9_23.

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Rongioletti, Franco. "Skin Diseases from Metabolic, Endocrinologic Diseases". In European Handbook of Dermatological Treatments, 891–904. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-45139-7_90.

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Rongioletti, Franco. "Skin Diseases from Metabolic, Endocrinologic Diseases". In European Handbook of Dermatological Treatments, 929–42. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-15130-9_89.

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Zhao, Juan, Jian-Fang Sun, Yong Xie, Guo-Xing Zhu, Jian-Hua Lin, Xue Li, Guang Zhao et al. "Metabolic and Nutritional Skin Diseases". In Atlas of Skin Disorders, 319–50. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8037-1_22.

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Mintoff, Dillion, e Anupam Das. "Metabolic Syndrome: Dermatological Aspects in Women". In Skin Diseases in Females, 249–59. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-6065-8_11.

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Gisondi, Paolo, e Giampiero Girolomoni. "Metabolic Syndrome in Psoriasis". In Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease, 95–98. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-60761-181-3_12.

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Montinari, Martina, e Franco Rongioletti. "Pituitary Gland Diseases". In Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease, 35–41. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-60761-181-3_4.

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Rongioletti, Franco. "Exogenous Cutaneous Deposits with Special Consideration to Skin Reactions to Soft-Tissue Fillers". In Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease, 181–89. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-60761-181-3_23.

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Calder, Kenneth B., e Bruce R. Smoller. "Adrenal Disease". In Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease, 3–10. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-60761-181-3_1.

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Atti di convegni sul tema "Metabolic Skin Diseases"

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Kingsmore, Kathryn M., Sneha Shrotri, Brittany A. Martinez, Prathyusha Bachali, Michelle D. Catalina, Andrea R. Daamen, Sarah E. Heuer, Robert D. Robl, Amrie C. Grammer e Peter E. Lipsky. "304 Metabolic dysregulation characterizes the tissue response to immune injury in systemic lupus erythematosus and inflammatory skin diseases". In LUPUS 21ST CENTURY 2021 CONFERENCE, Abstracts of the Fifth Biannual Scientific Meeting of the North and South American and Caribbean Lupus Community, Tucson, Arizona, USA – September 22–25, 2021. Lupus Foundation of America, 2021. http://dx.doi.org/10.1136/lupus-2021-lupus21century.13.

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Grech, Vasiliki Sofia, Kleomenis Lotsaris, Ioanna Grech, Vasiliki Kefala e Efstathios Rallis. "Semaglutide (Ozempic) and obesity. A comprehensive guide for aestheticians". In 1st Conference of the Hellenic Scientific Society of Aesthetics. PHARMAKON-Press, 2024. http://dx.doi.org/10.61873/rjdb1796.

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Abstract (sommario):
Obesity is a complex interplay of biological, genetic, behavioural, and environmental factors. Going beyond the con- ventional Body Mass Index (BMI) evaluation, the complex relationship between obesity and skin diseases unveils the evolving role of aesthetics in health promotion. Adipose tissue, traditionally seen as an energy reservoir, is unveiled as a dynamic endocrine organ, playing a crucial role in the pathophysiological mechanisms of insulin resistance and metabolic syndrome. This article navigates the skin-deep impact of obesity and unravelling its influence on dermato- logical challenges. From disrupted epidermal barriers to diseases such as psoriasis and hidradenitis suppurativa, it further explores how licensed cosmetologists emerge as health advocates. For what is more, semaglutide, a ground- breaking GLP-1 agonist, takes the spotlight, tracing its journey from FDA approval for type 2 diabetes to its recent endorsement for obesity. The article examines its mechanism, efficacy, and unintended consequences of popularity, emphasizing the need for responsible medication use.
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Kolokolоva, O. I. "STRONGYLOIDIASIS OF YOUNG CATTLE IN THE KALUGA REGION". In THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”, 2023. http://dx.doi.org/10.31016/978-5-6048555-6-0.2023.24.215-219.

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Strongyloidiasis is a widespread invasive disease of animals and humans caused by nematodes from the order Rhabditida of the family Strongyloididae, which includes more than 50 species. Strongyloides are developed in the same way in all types of animals with the alternation of parasitic and free-living generations (in analogy with heterogonies). Strongyloidiasis is a zoonosis; when it is diagnosed, autoinvasion is possible. Strongyloidiasis causes damage to the gastrointestinal tract, respiratory organs, circulatory and lymphatic systems in the hosts of the invasion, and leads to metabolic disorders, fever and anemia. Since the larvae migrate through the circulatory and lymphatic system, there is some suggestion that animals can become infected intrauterine. There is evidence that strongyloidiasis among animals causes vasculitis of the optic nerve, damage to the nervous system and brain with characteristic symptoms (loss of vision or consciousness, epilepsy, convulsions). When the larvae penetrate through the skin, dermatitis and ulcers occur. Infected animals refuse to eat, which leads to their cachexy and even death. In most cases, strongyloidiasis affects young livestock animals (piglets, calves, lambs, foals) aged up to 3-6 months. The difficulty of controlling strongyloidiasis lies in the fact that Strongylids are geohelminths and animals can become infected by contact with infected soil and litter. According to the study results, strongyloidiasis was detected in newborn calves, which indicates the need for testing for strongyloidiasis and deworming not only young animals, but the entire breeding stock.
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Finnegan, Jason, Bridget Peterkin, Hee-Chan Han, Jennifer M. Yentes, Stephen I. Rennard e Eric J. Markvicka. "Wireless, Battery Free Wearable Electronic Nose". In 2022 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/dmd2022-1038.

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Abstract Volatile organic compounds (VOCs) are excreted through the skin or exhaled breath. They are end products of human metabolism, metabolism of gut microflora, and ingested or inhaled substances. VOCs can be noninvasively sampled and could be a useful marker for disease. However, medical diagnostics rarely considers the VOCs that are expelled from the body. Here, we introduce a miniature, low-cost, and battery-free electronic nose (e-nose) sensor for passively identifying chemical patterns that are excreted from the human skin or exhaled breath. The platform is composed of an array of conductive polymer filaments created with a two-layer system of multi-walled carbon nanotubes and four different, solution processable polymers. The “breathprint” signature–consisting of the resistance of each filament–can be read from the sensor using a near-field communication-enabled device, such as a smartphone. The e-nose sensor contains a system on a chip with near-field communication (NFC) functionality and a radio frequency antenna to harvest power. The sensor was tested against six common VOCs that are released from the human body.
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Pirtini C¸etingu¨l, Mu¨ge, Cila Herman e Rhoda M. Alani. "Skin Imaging With Infrared Thermography and Confocal Microscopy". In ASME 2009 Heat Transfer Summer Conference collocated with the InterPACK09 and 3rd Energy Sustainability Conferences. ASMEDC, 2009. http://dx.doi.org/10.1115/ht2009-88462.

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The implementation of in vivo imaging technologies, such as digital photography, dermoscopy and confocal scanning laser reflectance microscopy (CSLM) in dermatology has led to recent improvements in recognizing skin lesions. Specifically, in the case of skin cancer, a key issue is that the rate of cancerous tissue growth and changes in its spatial extent with time are linked to the energy released locally by these uncontrolled metabolic processes. We believe that with a properly designed infrared (IR) imaging and measurement system combined with thermal analysis, one can characterize healthy and diseased tissue. This paper augments our previous work, in which we introduced a computational model to estimate the location and size of lesions using IR imaging data. In this paper, we focus on calibrating the IR camera and correcting its inherent artifacts. Calibration and corrections are first performed on a blackbody object and then on human skin images in order to acquire accurate surface temperature distributions. As future work, in addition to these correction steps, several other steps, such as accounting for emissivity variations will be developed for clinical studies. In addition to IR imaging, images acquired by in vivo confocal scanning laser microscopy are used to examine the structure of the human skin for different skin types. Our aim is to generate additional data necessary for the IR imaging model by further analyzing the 3D structure of healthy tissue and the lesion. Specifically, in clinical studies, confocal images will be used to describe thermal associations with skin lesion and its blood supply in order to refine our transient thermal model of skin tissue.
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Connizzo, Brianne K., Kenneth W. Liechty e Louis J. Soslowsky. "Altered Mechanical Properties and Fiber Re-Alignment in Diabetic Mouse Supraspinatus and Achilles Tendons". In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80129.

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Tendons function to transfer load, maintain alignment and permit motion in joints. To perform these functions, tendons have complex mechanical behavior which is modulated by the tissue’s structure and composition, such as the collagen fibers and surrounding extracellular matrix. When these matrix proteins are altered, the mechanical properties are also altered, which could potentially lead to reduced loading and healing capacity. Diabetes is a metabolic disease which, among other co-morbidities, has been associated with Achilles tendon disorganization and tendinopathy, as well as increased overall joint stiffness in humans [1]. We have recently reported that the skin from the Db/Db diabetic mouse, a model of Type II Diabetes, as well as the skin from human diabetics, have impaired biomechanical properties compared to non-diabetic skin as the result of altered extracellular matrix composition. [2]. However, the mechanical properties of tendons from these animals have never been studied and could serve as a unique model of altered collagen structure as well as provide further understanding to the cause of tendinous injuries in the diabetic population. Therefore, the objective of this study is to measure the tensile mechanical properties and collagen fiber re-alignment in the db/db mouse model compared to non-diabetic controls. We hypothesize that tendon stiffness and modulus will be increased in the db/db group in the insertion site and midsubstance, and that db/db tendons will re-align earlier and faster during the testing protocol.
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Vasconcelos, Matheus Felipe de Souza, Francisco Tomaz Meneses de Oliveira, Rafael Zini Moreira da Silva e Alex Michel Daoud. "Neurological and adrenal insufficiency symptons in adult x-linked adrenoleukodystrophy: case report". In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.347.

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Abstract (sommario):
Context: X-linked adrenoleukodystrophy (X-ALD) is a rare genetic demyelinating disease caused by mutations in ABC1 gen associated with an impairment of beta- oxidation of very long chain fatty acids (VLCFA) in peroxisomes. It causes accumulation of VCLFA in tissues affecting majoritary the central nervous system, testicles and the adrenal córtex resulting in symptoms which provides restricted neurological prognosis and sequels. Methods: Specific data related of a clinical case through prontuary and complementary exams in a patient attended at Santa Casa de Misericórdia de São Paulo hospital. Case report: Male patient, 39 years old, complaning about vomiting, hyperpigmented skin associated with abolish, psicoses, urinary incontinence, temporal and spacial confusion as well as were found: hyperkalaemia, hyponatremia, hypoglycemia, elevated ACTH levels, basal cortisol decresead, antibody anti-21-hidroxilase non reagente, screening for infectious agents were carried out and infection subsequently ruled out. Were observed in MRI Brain: hypersignal in cerebral white matter on T2-FLAIR sequence bilaterally in which the occipitoparietal region, frontal lobe and basal ganglia were more affected. After metabolic and hydroelectric disorders estabilization using Prednisone, Fludrocortisone per day for 5 days, he evolved with worsening of cognitive and behavioral status until nowdays. Actually, he is totally dependent on his basic activities. Conclusions: It is a rare disease, but it must be recognized by every neurologist, since it is can affect other systems and can leave serious sequelae.
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Sun, Feng, Robert Anderson e Guillermo Aguilar. "An Experimental Study of In Vitro Transdermal Drug Delivery Assisted by Cryopneumatic Technology". In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204240.

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Abstract (sommario):
Transdermal drug delivery (TDD) is a promising alternative to conventional drug delivery approaches, such as oral or injectable routes. In comparison, the primary benefits of TDD include [1]: 1) avoidance of first pass metabolism and other variables associated with the GI tract such as pH changes and gastric emptying time. 2) sustained and controlled delivery over a prolonged period of time. 3) reduction in side effects associated with systemic toxicity. 4) improved patient acceptance and compliance. 5) direct access to targeted or diseased site, e.g. treatment of skin disorders. 6) ease of dose termination in the event of any adverse reactions either systemic or local; 7) convenient and painless administration; 8) ease of use and reduction of overall health care treatment costs; 9) viable alternative in circumstances where oral dosing is not possible (in unconscious or nauseated patients).
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Ibarra-Prieto, Maria-Fernanda, Jose-Manuel Luna, Abel Hernandez-Guerrero e Jose-Luis Luviano-Ortiz. "Thermal Recovery of Cutaneous Neoplasm During Cryosurgery". In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-52816.

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Cryotherapy, also called cryosurgery, cryoablation or targeted cryoablation therapy, is a minimum invasive treatment that uses extreme cold temperatures to freeze and destroy damage tissue, like tumors or cancer cells. During cryotherapy, a refrigerant as liquid nitrogen or argon gas is forced to flow inside a probe. This probe is similar to a needle and it is called cryoprobe. Once the refrigerant is inside this cryoprobe the temperature decreases below zero Celsius in a given time, creating an intense cold that contacts the diseased tissue. Physicians use image guidance techniques to monitor the cryoprobe, such as ultrasound, computed tomography (CT) or magnetic resonance imaging (MRI). To destroy diseased tissue located outside the body, liquid nitrogen is applied directly to the infected zone with a cotton swab or spray. For tumors located below the skin surface and depth in the body, the medical image guidance to insert one or more cryoprobes is used. Living tissue, whether healthy or sick, cannot tolerate extremely low temperatures. For this reason cryotherapy involves a series of steps leading to cell death. Tumors are repeatedly frozen and thaw, typically two freeze – thaw cycles are used. Once the cells have been destroyed, white blood cells of the immune system remove dead tissue. The present work is a 3D simulation. The skin is modeled with a regular geometry, divided into three layers: epidermis, thinner and superficial part of the skin; dermis, 40 times thicker than the epidermis (also this layer has a thermoregulatory function because of the blood flow, which also contributes to vasoconstriction and vasodilatation of the skin), and finally the last layer is the hypodermis or subcutaneous fat layer (which mainly stores fat). For a transient analysis of this three layers of the skin, the bio-heat transfer equation of Pennes is used, since it contains terms that involve energy released during metabolism, blood perfusion, body core temperature and certain physical properties such as density, specific heat, thermal conductivity, latent heat of phase change and heat capacity ratio. The malignant tumor, melanoma, is modeled as an irregular symmetric geometry. Three different melanoma Clark levels are analyzed, Clark II, III and IV. Each level is analyzed with three size variations. These levels are chosen because most people who are diagnosed with melanoma have Clark II level. Clark V level was not considered because when melanoma reaches subcutaneous cellular tissue the metastasis process begins. In this work a thermal recovery analysis of the skin during certain periods of time in the freezing-thaw cycles is carried out. Each of this time periods vary according to the type of refrigerant, liquid nitrogen or argon gas. The analysis contemplates the phase change suffered by the skin.
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