Articoli di riviste sul tema "Meredith Monk"

La exposición de una voz que se desintegra, se desprovee de su carácter comunicativo y se hunde en un estrato precultural y protolingüístico, vertebra la obra vocal de Meredith Monk. Con su trabajo, la creadora -desde un modelo estético plural que abarca la actividad dramática, poética, musical y audiovisual- explora el terreno de la antropología de la cultura. La voz, en este modelo compositivo, se repliega tanto sobre su raíz musical como sobre técnicas expandidas: susurros, gritos, risas. En las siguientes páginas se ofrece una visión sintética de esta propuesta creativa desde una base epistemológica vertebrada por medio de motivos como el juego, la mímesis, la dialéctica entre composición y descomposición y el concepto de musilenguaje. Este último, trabajado por autores como Robert N. Bellah, Steven Brown o Steven Mithen, comprende la música como base del habla.

In her book Conversations with Meredith Monk, Bonnie Marranca publishes four conversations that occurred between 2008 and 2013, that is, in Monk’s mature period of creation, hence affording the artist occasion to reflect on her past work. Among other things, she affirms that her relationship to her work is informed by her practice of Buddhism. She refers to directorial method of “weaving” together the different media she uses when constructing her stage works, allowing her to connect the different worlds contained within different media and in so doing experience herself as an integrated being. She describes the creation of a work as the search for something fundamental, understanding each work as its own world, which she listens to and whose laws she searches for in an uninterrupted dialogue with the work as the subject. For her, the stage is a holy space, a space for ritual between performers and audience, in which an important role is played by shared time, unrepeatable and transient. The conversations with Monk reveal how her creative process heeds the internal desires of the creation and simultaneously ignores the instructions of established aesthetic guidelines.

Abstract Background: SAR’245 is a clinical-stage site-specific pegylated human IL-2 that blocks IL-2 alpha receptor binding but retains near-native binding affinity for beta/gamma IL-2 receptor subunits. When administered in preclinical models, a unique ‘T-cell remodeling’ MoA characterized by robust increase of CD8+Teff/CD4+Treg coupled with potent NK-cell activation/expansion was observed. Circulating tumor DNA (ctDNA) can be used as a non-invasive biomarker of early clinical response whilst overcoming challenges of obtaining repeat tumor biopsies from patients. Previously, we reported results of the Phase 1 HAMMER study (NCT04009681); herein, we describe an innovative integrative approach that considers peripheral key MoA biomarkers with objective response and dose-limiting toxicity (DLT) rate to help identify the recommended Phase 2 dose (RP2D) for SAR’245. Methods: SAR’245 was given IV as mono Q3W [Cohort B] or Q3W + IV pembro 200 mg Q3W/400 mg Q6W [Cohort C]. Joint modeling was carried out to account for the relationship between dose and 1) MoA biomarkers, and NK cells in blood measured by flow cytometry; 2) response surrogate biomarker: ctDNA measured by Guardant Omni 500 panel; and 3) DLTs. In the model, a latent variable was used to model correlation between DLT and the MoA or response surrogate biomarkers, Bayesian approach was used to derive posterior probabilities (PP) at each dose level of the target region (defined by >20% probability of fold change of biomarker values post-treatment above a predefined threshold and DLT rate <33%) and the PP of the overdose region (defined by DLT rate ≥33%). RP2D dose level was determined by maximizing the PP of target region among doses with PP of the overdose region probability <40%. Results: Samples from 35 subjects (Cohort B) and 34 subjects (Cohort C) were available. The results from SAR’245 mono suggests that the CD8/CD4 ratio and the concentrations of NK, CD8, and CD4 achieve maximum probability of reaching meaningful modulation (based on pre-defined threshold) around 32 ug/kg. When SAR’245 was combined with pembro, the results with PoM biomarkers showed the best performance at 24-32 µg/kg, while results with ctDNA showed the best results at 16-24 µg/kg. When all parameters were considered, either 24 or 32 µg/kg could serve as an adequate dose at Q3W scheduling. Conclusions: In early oncology studies, joint modeling using non-invasive biomarkers, including MoA and response biomarkers, and a safety profile can inform dose-response relationships and support RP2D selection. This innovative integrative modeling will guide clinical study design. Studies of SAR’245 that further explore the dosing and scheduling are on-going. Disclosures: This study was sponsored by Synthorx, a Sanofi company. Citation Format: Siqing Fu, Gerald S. Falchook, Minal Barve, Meredith McKean, Tira J. Tan, Charlotte Lemech, Cheng E. Chee, Neyssa Marina, Giovanni Abbadessa, Robin Meng, Federico Rotolo, Hong Wang, Jason Deng, Wenting Wang, Rui Wang, Tarek Meniawy. Joint modeling of safety and peripheral mode-of-action (MoA) biomarkers to support RP2D identification in Phase 1 study of SAR444245 (SAR’245) as monotherapy (mono) or combined with pembrolizumab (pembro) in patients with advanced solid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2155.

Abstract The development of effective cancer vaccines that can trigger strong and enduring memory T cell responses against specific tumor associated antigens (TAAs) is crucial for advancing immunotherapy. DNA-based cancer vaccines have shown promise in generating precise and long-lasting immune responses. In particular DNA vaccines are capable of inducing both humoral and cellular immune responses. In this study, we aimed to investigate the effectiveness of DNA vaccines targeting the mouse Tyrosine-related protein-2 (Trp2) and human New York esophageal squamous cell carcinoma 1 (NY-ESO-1) TAAs in mouse melanoma model. These DNA vaccines were formulated with a functionalized polymer designed to protect DNA from degradation and improve its bioavailability. DNA vaccines targeting both mouse Trp2 (pVACTR) and human NYESO-1 (pVACNY) were constructed. A mouse melanoma cell line (B16F10-NY) overexpressing human NYESO-1 was also generated and demonstrated to induce tumors in C57BL/6 mice. Female C57BL/6 mice received two doses of intramuscular (i.m.) injection of formulated pVACTR or pVACNY or a combination thereof, formulated with the synthetic functionalized polymer, with a 3-week interval. The DNA vaccination induced a potent T cell response, as evidenced by ELISPOT assays showing strong IFN-γ secreting T cells against NYESO-1 and Trp2. Flow cytometry analysis of spleenocytes showed strong IFN-γ and TNF-α secreting CD4 T cells against NYESO-1. We further evaluated the prophylactic and therapeutic efficacy of DNA vaccines targeting both Trp2 and NYESO-1 using a murine syngeneic model. Animals were challenged with a lethal dose of B16F10-NY two weeks after the second immunization exhibited a significant (p<0.0001) delay in tumor progression and a substantial increase in survival compared to the mock control group. In the therapeutic testing, animals challenged with B16F10-NY and subsequently vaccinated at 4, 11, and 25 days also demonstrated delayed tumor growth and prolonged survival. These findings indicate that formulated DNA vaccine delivered via i.m. triggers robust T cell responses and exhibit both prophylactic and therapeutic efficacy, leading to significantly prolonged survival and delayed tumor growth. A DNA-based vaccine independent of viral vector or device has potential to elicit potent anti-tumor responses with better safety and compliance. Citation Format: Kempaiah Rayavara, John Henderson, Meredyth Kinsella, Jessica Kim, Majed Matar, Subeena Sood, Olivia Signer, Chelsey Bellmon, Corinne Le Goff, Khursheed Anwer, Jean Boyer. Intramuscular delivery of tumor associated antigen DNA vaccines elicits strong cellular immune response, delays tumor growth and prolongs survival [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6748.

Abstract Introduction: M6223 is an intravenous (IV), fully human, antagonistic, anti-TIGIT antibody with an Fc-mediated effector region. In preclinical studies, M6223 combined with BA (a bifunctional fusion protein that simultaneously targets the TGF-β and PD-(L)1 pathways) enhanced antitumor efficacy compared to either agent alone. Methods: This first-in-human, dose escalation study of M6223 as monotherapy (M6223; Part 1A) or in combination with BA (M6223+BA; Part 1B) included pts with advanced solid tumors (aged ≥18 years, ECOG PS ≤1) (NCT04457778). In Part 1A, pts received M6223 at 10 mg, 30 mg, 100 mg, 300 mg, 900 mg, 1600 mg, 2400 mg (all Q2W) or M6223 2400 mg Q3W. In Part 1B, pts received M6223 at 300 mg, 900 mg, or 1600 mg, all in combination with BA 1200 mg (both Q2W, IV). Dose escalation decisions by the Safety Monitoring Committee were assisted by a Bayesian 2-parameter logistic regression model. Primary objectives were safety, tolerability, maximum tolerated dose (MTD), and recommended dose for expansion (RDE). Additional objectives included pharmacokinetics (PK), pharmacodynamics (PD), and clinical activity. Results: At final analysis, 40 pts (21 male, age range 24-79 years) had received M6223 (Q2W: n=32; Q3W: n=8), and 18 pts (7 male, age range 34-80 years) had received M6223+BA. Overall, two dose-limiting toxicities were observed: a grade 3 adrenal insufficiency (M6223, 900 mg) and a grade 3 anemia (M6223+BA, 300 mg; unrelated to M6223). In the M6223 group, grade ≥3 TEAEs were observed in 14 (35.0%) pts and M6223-related grade ≥3 TEAEs in 2 (5.0%) pts. In the M6223+BA group, grade ≥3 TEAEs were observed in 14 (77.8%) pts and M6223-related grade ≥3 TEAEs in 4 (22.2%) pts. No MTD was identified. RDEs were 1600 mg Q2W or 2400 mg Q3W for M6223 monotherapy, and 1600 mg+1200 mg Q2W for M6223+BA. Half-life for the two monotherapy RDEs were 9.0 and 14.6 days, respectively, with moderate accumulation at the selected RDEs. Linear PK was observed for M6223 at 100-2400 mg Q2W and at 2400 mg Q3W; co-administration with BA did not change the PK profile of M6223. PD analyses in blood showed full and sustained TIGIT target occupancy, and depletion of suppressive Tregs at M6223 ≥900 mg. Paired biopsies in the M6223 group (900 mg Q2W, 1600 mg Q2W, 2400 mg Q3W; n=12) showed a trend of decrease in TIGIT+ and increase in CD226+ cells. Median overall survival was 7.6 months (95% CI: 4.9, 12.0) and median progression-free survival was 1.4 months (95% CI: 1.3, 1.8). No pt achieved an objective response (per RECIST v1.1); stable disease as the best response was observed in 13 (32.5%) pts in M6223 and 5 (27.8%) pts in M6223+BA. Conclusion: M6223 monotherapy and in combination with BA had a manageable safety profile, and RDEs for both mono- and combination therapy were defined. Further evaluation of M6223 is ongoing in combination with PD-L1 inhibitor avelumab (JAVELIN Bladder Medley; NCT05327530). Citation Format: Aung Naing, Meredith McKean, Anthony Tolcher, Anja Victor, Ping Hu, Keyvan Tadjalli Mehr, Thomas Kitzing, Daniel Holland, Emilia Richter, Lillian Siu. First-in-human trial of TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa (BA) in patients (pts) with advanced solid unresectable tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr CT184.

“Notes on the voice” foi publicado originalmente na revista literária The Painted Bride Quarterly, no ano de 1976, juntamente com o manuscrito comentado da partitura da obra “Our lady of late” (Monk, 1976). Em 1997 o texto foi republicado em uma coletânea organizada pela crítica de dança norte-americana Deborah Jowitt contendo alguns escritos de Monk, além de resenhas e artigos sobre sua obra (ver Monk, 1997). O texto é formado por dez notas: as nove primeiras podem ser consideradas um sumário das ideias de Monk sobre a voz, e a última é uma compilação de como estas ideias foram sendo aplicadas às suas criações até aquele momento.

Nesta entrevista, a artista multidisciplinar estadunidense Meredith Monk fala sobre o seu percurso nas artes performativas e, mais especificamente, a participação de crianças em suas obras. Monk trata de temas como o budismo, os caminhos e as escolhas como artista, as artes da presença, o envelhecimento e as noções de tradição e legado.

Abstract Embodied composition is the practice of organizing sound in relation to the body and its internal/external experiences. It includes the intuitive and corporeal capacity to create, remember and respond to the environment. This creative practice manifests in the use of voice, gesture, and the creative state. While many composers work with embodied composition, a clear definition is lacking. Towards this end, the author offers a perspective from her own creative practice as research. Her definition is illustrated with examples from Meredith Monk, Pamela Z, and Cassandra Miller.

It all started with a tweet. On the afternoon of 2 June 2013, Professor Geoffrey Miller, an evolutionary psychologist at the University of New Mexico (UNM) and visiting instructor at New York University (NYU), tweeted out a message that would go on to generate a significant social media controversy. Addressing aspiring doctoral program applicants, Miller wrote:Dear obese PhD applicants: if you didn’t have the willpower to stop eating carbs, you won't have the willpower to do a dissertation #truthThe response to Miller’s tweet was swift and fiery. Social media users began engaging with him on Twitter, and in the early hours of the controversy Miller defended the tweet. When one critic described his message as “judgmental,” Miller replied that doing a dissertation is “about willpower/conscientiousness, not just smarts” (Trotter). The tweet above, now screen captured, was shared widely and debated by journalists, Fat Acceptance activists, and academic social media users. Within hours Miller had deleted the tweet and replaced it with two new ones:My sincere apologies to all for that idiotic, impulsive, and badly judged tweet. It does not reflect my true views, values, or standards andObviously my previous tweet does not represent the selection policies of any university, or my own selection criteriaHe then made his Twitter account private. The captured image, however, continued to spread. Across social media, users began to circulate a campaign that called for Miller to be formally disciplined (Trotter). There was also widespread talk about potential lawsuits from prospective students who were not selected for admission at UNM (Kirby). Indeed, the Fat Chick Sings blogger Jeanette DePatie offered her own advice to Miller: #findagoodlawyer.Soon after the controversy emerged a response appeared on UNM’s website in the form of a video statement by Professor Jane Ellen Smith, the Chair of the UNM Psychology Department. Smith reiterated that Miller’s statements did not reflect the “policies and admissions standards of UNM”. She also stated that Miller had defended his actions by claiming the tweet was part of a “research project” where he would deliberately send out provocative messages in order to measure the public response to them. This claim was met with incredulity by a number of bloggers and columnists, and was later determined to be incorrect in an Institutional Review Board inquiry at UNM, which concluded Miller’s tweets were “self-promotional” in nature. Following a formal investigation, the UNM committee found no evidence that Miller had discriminated against overweight students. It did however pass a motion of censure that included a number of restrictions, including prohibiting Miller from sitting on any graduate admission committee at UNM.The #truth about Fat PhDs?Readers may be wondering why Miller’s tweet continues to matter as I write this article in 2015. It is my belief that the tweet is important insofar as it affords an insight into the cultural scene that surrounds the fat body in higher education. The vigorous debate generated by Miller’s tweet offers researchers a diverse array of media texts that are available to help build a more comprehensive picture of fat embodiment within higher education.Looking at the tweet in the cold light of day it is difficult to imagine any logical links one might infer between a person’s carbohydrate consumption and their ability to excel in doctoral education. And there’s the rub. Of course Miller’s tweet does not represent a careful evaluation of the properties of doctoral willpower. In order to make sense of the tweet we need to understand the ways cultural assumptions about fatness operate. For decades now, researchers have documented the existence of anti-fat attitudes (Crandall & Martinez). Increasingly, scholars and Fat Acceptance activists have described a “thinness norm” that is reproduced across contemporary Western cultures, which discerns normatively slender bodies as “both healthy and beautiful” (Eller 220) and those whose bodies depart from this norm, as “socially acceptable targets for shaming and hate speech” (Eller 220). In order to be intelligible Miller’s tweet relies on a number of deeply entrenched cultural meanings attributed to fatness and fat people.The first is that body-size is primarily a matter of self-control. Although Critical Fat Studies researchers have argued for some time that body weight is determined by complex interactions between the biological and environmental, the belief that a large body size is caused by limited self-control remains prevalent. This in turn supports a host of cultural connotations, which tend to constitute fat people as “lazy, gluttonous, greedy, immoral, uncontrolled, stupid, ugly and lacking in willpower” (Farrell 4).In light of the above, Miller’s message ought to be read as a moral one. I have paraphrased its logic as such: if you [the fat doctoral student] lack the willpower to discipline your body into normatively desired slimness, you will also likely lack the strength of character required to discipline your body-mind into producing a doctoral dissertation. The sad irony here is that, if anything, the attitudes that might hamper fat students from pursuing a doctoral education would be those espoused in Miller’s own tweet. As Critical Fat Studies researchers have illuminated, the anti-fat attitudes the tweet reproduces generate challenging higher education climates for fat people to navigate (Pausé, Express Yourself 6).Indeed, while Miller’s tweet is one case that arose to media prominence, there is evidence that it sits inside a wider pattern of weight discrimination within higher education. For example, Caning and Mayer (“Obesity: Its Possible”, “Obesity: An Influence”) found that despite similar high school performances, ‘obese’ students were less likely to be accepted to elite universities, than their non-obese peers. In a more recent US-based study, Burmeister and colleagues found evidence of weight bias in graduate school admissions. In particular, they found that higher body mass index (BMI) applicants received fewer post-interview offers into psychology graduate programs than other students (920), and this relationship appeared to be stronger for female applicants (920). This picture is supported by a study by Swami and Monk, who examined weight bias against women in a hypothetical scenario about university acceptance. In this study, 198 volunteers in the UK were asked to identify the women they were most and least likely to select for a place at university. Swami and Monk found that participants were biased against fat women, a finding which the authors interpreted as evidence of broader public beliefs about body size and access to higher education.In my examination of the media scene surrounding the Miller case I observed that most commentators associated the tweet with a particular affective formation – shame. Miller’s actions were widely described as “fat-shaming” (Bennet-Smith; Ingeno; Martin; Trotter; Walsh) with Miller himself often referred to simply as the “fat-shaming professor” (King; ThinkTank). In this article I wish to consider the affective-political dimensions of Miller’s tweet, by focusing on one digital community’s response to it: Fuck Yeah! Fat PhDs. In following this path I am building on the work of other researchers who have considered fat activisms and Web 2.0 (Pausé, Express Yourself); fat visual activism (Gurrieri); and the emotional politics of fat acceptance blogging (Kargbo; Bronstein).Imaging Alternatives: Fuck Yeah! Fat PhDsBy 3 June 2013 – just one day after Miller’s tweet was published – New Zealand-based academic Cat Pausé had created the Tumblr Fuck Yeah! Fat PhDs. This was billed as a photo-blog about “being fatlicious in academia”. Writing on her Friend of Marilyn blog, Pausé explained the rationale behind the Tumblr:I decided that what I wanted to do was to highlight all the amazing fat individuals who are in graduate school, or have completed graduate school – to provide a visual repository … and to celebrate the amazing work being done by these rad fatties!Pausé sent out calls for participants on Twitter, Tumblr and Facebook, and emailed a Fat Studies listserv. She asked submitters to send “a photo, along with their name, degree, and awarding institution” (Pausé Express Yourself, 6). Images were submitted thick and fast. Twenty-three were published in the first day of the project, and twenty in the second. At the time of writing, just over 150 images had been submitted, the most recent being November 2013.The Fuck Yeah! Fat PhDs project ought to be understood as part the turn away from the textual toward the digital in fat activist movements (Kargbo). This has seen a growth in online communities that are interested in developing “counter-images in response to the fat body’s position as the abject, excluded Other of the socially acceptable body” (Kargbo 162). Examples include a multitude of Fatshion photo-blogs, Tumblrs like Exciting Fat People or the Stocky Bodies image library, which responds to the limited diversity of visual representations of fat people in the mainstream media (Gurrieri).For this article, I have read the images on the Fuck Yeah! Fat PhDs Tumblr in order to gain an impression about the affective-political work accomplished by this collective of self-identified fat academic bodies. As I indicated earlier, much of the commentary following Miller’s tweet characterised it as an attempt to ‘shame’ fat doctoral students. As Elspeth Probyn has identified, shame frequently manifests itself on the body “most experiences of shame make you want to disappear, to hide away and to cover yourself” (Probyn 329). I suggest that the core work of the Fuck Yeah! Fat PhDs Tumblr is to address the spectre of shame Miller’s tweet projects with visibility, rather than it’s opposite. This visibility also enables the project to proliferate a host of different ways of (feeling about) being fat and doctoral.The first image posted on the Tumblr is Pausé’s own. She is pictured smiling at the 2007 graduation ceremony where she received her own PhD, surrounded by fellow graduates in academic regalia. Her image is followed by many others, mostly white women, who attest to the academic attainments of fat individuals. My first impression as I scrolled through the Tumblr was to note that many of the images (51) referenced scenes of graduation, where subjects wore robes, caps or posed with higher degree certificates. Many more were the kinds of photographs that one might expect to be taken at an academic event. Together, these images attest to the viability of the living, breathing doctoral body - a particularly relevant response given Miller’s tweet. This work to legitimate the fat doctoral body was also accomplished through the submission of two historical photographs of Albert Einstein, a figure who is neither living nor breathing, but highly unlikely to be described as lacking academic ability or willpower.As I read through the Tumblr subsequent times, I noticed that many of the submitters offered images that challenge stereotypical representations of the fat body. As a number of writers have noted, fat people tend to be visually represented as “solitary, lonely figures whose expressions are downcast and dejected” (Gurrieri 202). That is if they aren’t already decapitated in the visual convention of the “headless fatty” used across news media (Kargbo 160). Like the Stocky Bodies project, the Fuck Yeah! Fat PhDs Tumblr facilitated a more diverse and less pathologising representation of fat (doctoral) embodiment.Across the images there is little evidence of the downcast eyes of shame and dejection that Miller’s tweet seems to invite of aspiring fat doctoral candidates. Scrolling through the Tumblr one encounters images of fat people singing, swimming, creating art, playing sport, smoking, smiling, dressing up, and making music. A number of images (12) emphasise the social nature of fat doctoral life, by picturing multiple subjects at once, some holding hands, others posing with colleagues, loved ones, and a puppy. Another category of submissions took a playful stance vis-à-vis some representational conventions of imaging fatness. Where portrayals of the fat body from side or rear angles, or images of fat people eating and drinking typically code an affective scene of disgust (Gurrieri), a number of images on the Tumblr appear to reinscribe these scenes with new meaning. Viewers are offered pictures of smiling and contented fat graduates unashamed to eat and drink, or be represented from ‘unflattering’ angles.Furthermore, a number of images offered alternatives to the conventional representation of the fat subject as ugly and sexually unattractive by posing in glamorous shots bubbling with allure and desire. In one memorable picture, blogger and educator Virgie Tovar is snapped wearing a “sex instructor” badge and laughs while holding two sex toys.Reading across the images it becomes clear that the Tumblr offers a powerful response to the visual convention of representing the solitary, lonely fat person. Rather than presenting isolated fat doctoral students the act of holding the images together generates a sense of fat higher education community, as Kargbo notes:A single image posted online amidst vast Internet ephemera is just a fleeting document of a moment in a stranger’s life. But in the plural, as one scrolls through hundreds of images eager to hit the ‘next’ button for what will be a repetition of the same, the image takes on a new function: it becomes an insistent testament to the liveness of fat embodiment in the present. (164)Obesity Timebomb blogger Charlotte Cooper (2013) commented on the significance of the project: “It is pretty amazing to see the names and faces as I scroll through Fuck yeah! Fat PhDs. Many of us are friends and collaborators and the site represents a new community of power.”Concluding Thoughts: Fat Embodiment and Higher Education CulturesThis article has examined a cultural event that that saw the figure of the fat doctoral student rise to international media prominence in 2013. I have argued that while Miller’s tweet can be read as illustrative of the affective scene of shame that surrounds the fat body in higher education, the images offered by the Fuck Yeah! photo submitters work to re-negotiate implication in social discourses of abjection. Indeed, the images assert that alternative ways of feeling about being fat and doctoral remain viable. Fat students can be contented, ambivalent, sultry, pissed off, passionate and proud – and Fuck Yeah! Fat PhDs provides submitters with a platform to perform a wide array of these affects. This is not to say that shame is shut out of the project, or the lives of submitters’ altogether. Instead, I am suggesting that the Tumblr generates a more open field of possibilities, providing “a space for re-imagining new forms of attachments and identifications.” (Kargbo 171). Critics might argue that this Tumblr is not particularly novel when set in the context of a range of fat photo-blogs that have sprung up across the Internet in recent years. I would argue, however, that when we consider the kinds of questions Fuck Yeah! Fat PhDs might ask of university cultures, and the prompts it offers to higher education researchers, the Tumblr can be seen to make an important contribution. I am in agreement with Kargbo (2013) when she argues that fat photo-blogs “have the potential to alter the conditions of visual reception and perception”. That is, through their “codes and conventions, styles of lighting and modes of address, photographs literally show us how to relate to another person” (Singer 602). When read together, the Fuck Yeah! images insist that a different kind of relationship to fat PhDs is possible, one that exceeds the shaming visible in Miller’s tweet. Ultimately then, the Tumblr is a call to take fat doctoral students seriously, not as problems in need of fixing, but as a diverse group of scholars who make important contributions to the academy and beyond.I would like to use the occasion of concluding this article to call for further conversations about fat embodiment and higher education cultures. The area is significantly under-researched, with higher education scholars largely failing to engage with the material and affective experiences of fat embodiment. Indeed, I would argue that if nothing else, this paper has demonstrated that public scenes of knowledge creation have done a much more comprehensive job of analysing the intersection of ‘fat + university’ than academic books and articles to date. While not offering an exhaustive sketch, I would like to gesture toward some areas that might contribute to a future research agenda. For example, researchers might begin to approach the experience of living, working and studying as a fat person in the contemporary university. Such research might examine whose body the university is imagined and designed for, as well as the campus climate experienced by fat individuals. Researchers might consider how body size could become a part of broader conversations about embodiment and privilege in higher education, alongside race, ability, gender identity, and other categories of social difference.Thinking about the intersection of ‘fat + university’ would also involve tracing possibilities. For example, what role do university campuses play as spaces of fat activism and solidarity? And, what is the contribution made by Critical Fat Studies as a newly established interdisciplinary field of inquiry?Taken together, I hope the questions I have raised in this article demonstrate that the intersection of ‘fat’ and higher education cultures represents a rich and valuable area that warrants further inquiry.ReferencesBennet-Smith, Meredith. “Geoffrey Miller, Visiting NYU Professor, Slammed for Fat-Shaming Obese PhD Candidates.” 6 Apr. 2013. The Huffington Post. ‹http://www.huffingtonpost.com/2013/06/04/geoffrey-miller-fat-shaming-nyu-phd_n_3385641.html›.Bronstein, Carolyn. “Fat Acceptance Blogging, Female Bodies and the Politics of Emotion.” Feral Feminisms 3 (2015): 106-118. Burmeister, Jacob, Allison Kiefner, Robert Carels, and Dara Mushner-Eizenman. “Weight Bias in Graduate School Admissions.” Obesity 21 (2013): 918-920.Canning, Helen, and Jean Mayer. “Obesity: Its Possible Effect on College Acceptance.” The New England Journal of Medicine 275 (1966): 1172-1174. Canning, Helen, and Jean Mayer. “Obesity: An Influence on High School Performance.” The American Journal of Clinical Nutrition 20 (1967): 352-354. Cooper, Charlotte. “The Curious Case of Dr. Miller and His Tweet.” Obesity Timebomb 4 June 2013. ‹http://obesitytimebomb.blogspot.com/2013/06/the-curious-case-of-dr-miller-and-his.html›.Crandall, Christian, and Rebecca Martinez. “Culture, Ideology, and Antifat Attitudes.” Personality and Social Psychology Bulletin 22 (1996): 1165-1176.DePatie, Jeanette. “Dear Dr. Terrible Your Bigotry Is Showing...” The Fat Chick Sings 2 June 2013. ‹http://fatchicksings.com/2013/06/02/dear-dr-terrible-your-bigotry-is-showing/›.Eller, G.M. “On Fat Oppression.” Kennedy Institute of Ethics Journal 24 (2014): 219-245. Farrell, Amy. Fat Shame: Stigma and the Fat Body in American Culture. New York: NYU Press, 2011. Gurrieri, Lauren. “Stocky Bodies: Fat Visual Activism.” Fat Studies 2 (2013): 197-209. Ingeno, Lauren. “Fat-Shaming in Academe.” Inside Higher Ed 4 June 2013. Kargbo, Majida. “Toward a New Relationality: Digital Photography, Shame, and the Fat Subject.” Fat Studies 2 (2013): 160-172.King, Barbara. “The Fat-Shaming Professor: A Twitter-Fueled Firestorm.” Cosmos & Culture 13.7 (2013) Kirby, Marianne. “How Not to Twitter: Dr. Geoffrey Miller's 140 Fat-Hating Characters of Infamy.” XoJane 5 June 2013. ‹http://www.xojane.com/issues/professor-geoffrey-miller›.Martin, Adam. “NYU Professor Immediately Regrets Fat-Shaming Potential Students.” New York Magazine June 2013. ‹http://nymag.com/daily/intelligencer/2013/06/nyu-professor-immediately-regrets-fat-shaming.html›.Pausé, Cat. “On That Tweet – Fat Discrimination in the Education Sector.” Friend of Marilyn 5 June 2013. ‹http://friendofmarilyn.com/2013/06/05/on-that-tweet-fat-discrimination-in-the-education-sector/›.Pausé, Cat. “Express Yourself: Fat Activism in the Web 2.0 Age.” The Politics of Size: Perspectives from the Fat-Acceptance Movement. Ed. Ragen Chastain. New York: ABC-CLIO, 2015. 1-8. Probyn, Elspeth. “Everyday Shame.” Cultural Studies 18.2-3 (2004): 328-349. Singer, T. Benjamin. “From the Medical Gaze to Sublime Mutations: The Ethics of (Re)viewing Non-Normative Body Images.” The Transgender Studies Reader. Eds. Susan Stryker and Stephen Whittle. New York: Routledge, 2013. 601-620. Swami, Viren, and Rachael Monk. “Weight Bias against Women in a University Acceptance Scenario.” Journal of General Psychology 140.1 (2013): 45-56.Sword, Helen. “The Writer’s Diet.” ‹http://writersdiet.com/WT.php?home›.ThinkTank. “'Fat Shaming Professor' Gives RIDICULOUS Excuse – Check This Out (Update).” ThinkTank 8 July 2013. ‹https://www.youtube.com/watch?v=_Ey9TkG18-o›.Trotter, J.K. “How Twitter Schooled an NYU Professor about Fat-Shaming.” The Atlantic Wire 2013. ‹http://www.thewire.com/national/2013/06/how-twitter-schooled-nyu-professor-about-fat-shaming/65833/›.Walsh, Michael. “NYU Visiting Professor Insults the Obese Ph.D.s with ‘Impulsive’ Tweet.” New York Daily News 2013.