Tesi sul tema "Medical and Health Sciences"
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Solomon, Clifford E. "Evaluating spatial abilities in health sciences students /". Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/7680.
Testo completoGalper, Carol Quillman. "Evidence of professional values in a rural medical education program: Implications for medical education leaders". Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/279943.
Testo completoShingler, Arshia Ahmadi. "Oral Health in a Medical Setting". VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd_retro/91.
Testo completoCepoiu, Monica Elena. "Recognition of depression in elderly medical inpatients". Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97920.
Testo completoObjectives. To evaluate the validity of four recognition indicators and a global measure of recognition against a diagnosis of depression and the effect of patient characteristics on recognition of depression.
Methods. In a cohort of 264 medical inpatients 65 years and over (115 with major or minor depression, 78 with no depression), using data from two previous studies, sensitivities, specificities, and diagnostic odds ratios (DOR) of four indicators of recognition (Diagnosis, Symptoms, Treatment and Referral) and a global measure of recognition (any of the four indicators) were calculated. Stratified analysis was conducted to assess recognition by age, gender, history of depression, antidepressant use before admission, severity of depression, comorbidity, duration of hospitalization, disability and hospital of admission. The associations of patient characteristics with recognition were described among patients with major or minor depression using multiple logistic regression.
Results. Less than half of the patients were recognized according to the global measure of recognition. The indicator with the highest sensitivity was Treatment (27.8%, 95% CI: 20.0-37.0), while the indicator with the best specificity was Diagnosis (96.6%, 95% CI:91.9-98.7). The unadjusted DOR of global recognition was 2.6 (95% CI: 1.5, 4.4). Comorbidity, severity of depression, history of depression, duration of hospitalization, antidepressant use before admission and hospital of admission were significantly associated with global recognition.
Conclusion. Recognition of depression in elderly medical inpatients is low. Identifying factors that hinder recognition may guide interventions aimed at improving diagnosis and treatment of depression in elderly medical inpatients.
Immonen, K. (Kati). "Continuing professional development of medical laboratory professionals". Bachelor's thesis, University of Oulu, 2018. http://urn.fi/URN:NBN:fi:oulu-201805221864.
Testo completoBackhouse, Peter. "Medical knowledge, medical power : doctors and health policy in Australia /". Title page, contents and abstract only, 1994. http://web4.library.adelaide.edu.au/theses/09PH/09phb126.pdf.
Testo completoGu, Chushu. "Estimating life-expectancy changes for medical decision making: New approximations". Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27247.
Testo completoMarshall, Shawn Calder. "Evaluation of restricted driver licensing for medical impairments in Saskatchewan". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ57137.pdf.
Testo completoHan, Ling 1955. "Depression, medication use, and cognitive functioning in older medical patients". Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103161.
Testo completoIn the first three chapters, the concept, population burden and measurement of depression and cognitive function in the elderly population are described. The relevant literature is reviewed, and the rationale and approaches of this thesis are presented.
In the fourth chapter (1st manuscript), the short-term temporal relationship between depression and cognitive functioning was explored using an interviewer-rated depression severity scale. Based on competing mixed effects models under alternative temporal assumptions, the severity of depression symptoms appeared to have a concurrent rather than prospective relationship with cognitive functioning.
In the fifth chapter (2nd manuscript), diagnostic criteria were used to define depression. After adjusting for covariates, both major and minor depression were significantly predictive of subsequent cognitive decline, and the strength of the association appeared to increase with the duration of "exposure".
In the sixth chapter (3rd manuscript), using a provincial prescription database, the effects of medication exposure on cognitive function were evaluated. Antidepressant use was not associated with cognitive decline in general, but interacted with depression diagnoses. In exploratory analyses, antidepressant use appeared to be associated with improved cognitive function over time in the minor depression group, independent of comorbid diseases, current depression symptoms and concomitant medications. Both major and minor depression were independently predictive of subsequent cognitive decline, especially in those not prescribed antidepressants.
In summary, this thesis demonstrates that, in this sample of older medical inpatients, both major and minor depression are independent risk factors for 12-month cognitive decline. The potentially beneficial effects of antidepressants for patients with minor depression should be investigated.
Grantham, Sarah Catherine. "Dual Eligibles' Experience of Care in North Carolina's Patient-Centered Medical Home". Thesis, The George Washington University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3617167.
Testo completoIndividuals enrolled in both the Medicare and Medicaid programs, the "dually eligible," are generally vulnerable and face a wide range of health care needs; numerous studies have found that their health care is beset with problems of cost and quality. Health policy researchers find that these problems are directly associated with the inadequate coordination of benefits and services, but studies about care coordination have largely used quantitative approaches and focused on providers—they have not explored the critical perspective of patients receiving the care. To improve the complex processes of care coordination, this hybrid case study examines the experience of a sample of dual eligible enrollees served in North Carolina's patient centered medical home, and care managers. The subjects were generally independently living, and at lower-risk that typical dual eligibles. Although some experienced some continuity of care issues within NC's PCMH, generally they described receiving the right care, at the right time, in the right care settings. However, some experienced barriers to accessing necessary care, especially in the areas of prescription drugs and navigating the health care delivery system. Some of these challenges could potentially be resolved by NC's PCMH, but many issues are outside the program's control. Care managers who were interviewed suggested modifications to the Agency for Healthcare Research and Quality's Care Coordination Ring, which represents care coordination for a more stable, middle-class population than the dual eligibles they serve.
Houston, Andrea Lynn 1954. "Knowledge integration for medical informatics: An experiment on a cancer information system". Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/288868.
Testo completoSonico, Eric A. "Implementation and utilization of electronic medical records| An analysis". Thesis, California State University, Long Beach, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=1522655.
Testo completoThis master's thesis will present a literature review and analysis ofthe implementation and use of Electronic Medical Records (EMR). The literature review will discuss reasons that support implementation of EMRs, factors that are necessary for successful implementation and barriers that impede implementation. Also, real-world examples of implementation for medical billing in healthcare organizations will be discussed, as well as the disparity in implementation rates between larger and smaller healthcare organizations.
The analysis portion of this thesis will include data from the 2009 National Ambulatory Medical Survey (NAMCS) EMR Supplement and, through the application of the Chi-Square statistical test using SPSS, will assess whether size of the medical practice in terms of number of physicians is significantly associated with EMR implementation and functionality, the latter of which includes clinical reminders and prescription ordering. It will be shown that physician size is indeed significantly associated with implementation and functionality.
Öhrn, Anna. "The use of mobile health applications and health improvements". Thesis, Blekinge Tekniska Högskola, Institutionen för industriell ekonomi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-16791.
Testo completoMansman, Robert William II. "Oral Health Services in a Medical Setting". VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd/753.
Testo completoGreen, Janeth, e Seiko Ishikawa. "Vårdvetenskaplig forskning : En innehållsanalys av 3 utgåvor av Scandinavian Journal of Caring Sciences". Thesis, Mälardalens högskola, Akademin för hälsa, vård och välfärd, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-42538.
Testo completoKingsley, Karmon L. "Medical Assisting Credentialing". Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etd/2599.
Testo completoSalamah, Hanaan. "Potential barriers to seeking medical care| Does obesity and/or self-esteem result in decreased frequency of necessary medical office visits?" Thesis, California State University, Long Beach, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=1522651.
Testo completoObesity has arisen as a major cause of morbidity and mortality in today' s society. The aim of this study was to assess potential barriers encountered by obese women seeking medical care. It was hypothesized that overweight or obese women will be likely to have a negative self-esteem and that a negative self-esteem associated with being overweight will decrease healthcare utilization. A convenience sample of 50 women over the age of 18 were surveyed upon entering a health care clinic. Self-report of height and weight was collected to calculate a body mass index (BMI) score. Furthermore, a self-report of healthcare utilization was obtained along with demographic data and a quantified self-esteem score. Results showed a significant Pearson's negative correlation between BMI and the self-esteem score (r = -0.395; p = 0.01) and a significant difference based on a t-test between self-esteem based on employment status ( p = 0.021). Other demographic variables (age, income, education, marital status, and race) had no significant impact on BMI, self-esteem or number of office visits. There was no significant difference between obese and non-obese women on the number or type of office visits, and no significant difference between average self-esteem score and number of medical office visits. Assessing self-esteem in those with higher BMIs may be a helpful tool in assisting providers to identify barriers of seeking healthcare in obese women.
Loeben, Gregory Scott. "Medical futility and the goals of medicine". Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/288943.
Testo completoBrahmi, Frances A. "Medical students' perception of lifelong learning at Indiana University School of Medicine". [Bloomington, Ind.] : Indiana University, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3297081.
Testo completoTitle from dissertation home page (viewed Sept. 24, 2008). Source: Dissertation Abstracts International, Volume: 69-02, Section: A, page: 0414. Adviser: Debora Shaw.
Frey, William R. "Organization and change in medical rehabilitation /". The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487584612164495.
Testo completoSardeye, Hamdi. "Mental health of immigrants in Sweden : A scoping review". Thesis, Mälardalens högskola, Akademin för hälsa, vård och välfärd, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-48842.
Testo completoOkrainec, Karen. "Cardiac medical therapy following coronary artery bypass graft surgery". Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80344.
Testo completoThe use of aspirin, clopidogrel, coumadin, anti-lipid agents, anti-ischemic medications (beta-blockers, CCB's, nitrates) and ACE inhibitors was then examined among patients enrolled in the Routine versus Selective Exercise Treadmill Testing After Coronary Artery Bypass Graft Surgery (ROSETTA-CABG) Study. We examined the use of these medications among all patients as well as patients with various co-morbidities.
Heath, Hayden Lee. "Assessing Program-Readiness for Dental/Medical Tolerance". Thesis, University of North Texas, 2019. https://digital.library.unt.edu/ark:/67531/metadc1505149/.
Testo completoThangathurai, Duraiyah. "Wounded Patients, Wounded Doctors, Wounded Healers| Healing Our Fragmented Medical System". Thesis, Pacifica Graduate Institute, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10007090.
Testo completoThe purpose of this study is to examine the role of physicians in the process of healing within the context of our current medical system. As an autoethnographic study, it explores the healing process from wounds the researcher experienced as a physician, teacher, student, and at times a sick patient. This study reflects on the experiences, insights, and observations that have molded the researcher’s spirit toward that of a healer not only of patients but also of the fragmented medical system. This study explores the early childhood experiences and wounds that were instrumental in the researcher’s initial pursuit of a medical career. In addition, this study explores how the researcher’s journey of over 40 years, dedicated to practicing high tech, high risk, intensive care medicine of critically ill patients has deeply shaped the researcher’s persona as a healer. Since the time of the researcher’s initial specialization in medicine, other areas of medicine as well as other disciplines relating to the humanities have been explored. This study incorporates the lessons, knowledge, experiences, and perspectives from those disciplines and thereby expands the scope of this research study. The autoethnographic approach is appropriate for gaining a greater understanding of self, others, and the culture. The essence of healing necessitates the integration of mind, body, spirit, and consciousness, which encompass multiple therapeutic approaches. In summary, the healing process incorporates aspects of both art and science that optimally benefit not only the patient, doctor, and healer, but also the medical system.
Sunesson, Evelina. "Maintaining Physical Activity to Improve Health among Adolescents with Depression". Thesis, Högskolan i Halmstad, Akademin för hälsa och välfärd, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-42620.
Testo completoGyllensvärd, Harald. "Health Economic Aspects of Injury Prevention at the Municipal Level". Licentiate thesis, Linköpings universitet, Avdelningen för samhällsmedicin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-106227.
Testo completoClark, Spencer R. "Health Care Reform's Effect on Private Medical Practices". Scholarship @ Claremont, 2011. http://scholarship.claremont.edu/cmc_theses/209.
Testo completoKairouz, Joseph. "Patient data management system medical knowledge-base evaluation". Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=24060.
Testo completoFollowing a literature survey on evaluation techniques and architecture of existing expert systems, an overview of the Patient Data Management System hardware and software components is presented. The design of the Expert Monitoring System is elaborated. Following its installation in the intensive Care Unit, the performance of the Expert Monitoring System is evaluated, operating on real vital sign data and corrections were formulated. A progressive evaluation technique, new methodology for evaluating an expert system knowledge-base is proposed for subsequent corrections and evaluations of the Expert Monitoring System.
Looper, Karl J. "Perceived stigma in functional somatic syndromes and comparable medical conditions". Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33800.
Testo completoMethods. Subjects in three FSS groups, irritable bowel syndrome (IBS), fibromyalgia (FM), and chronic fatigue syndrome (CFS), were matched to medical control groups. Self-report measures were used to collect sociodemographic information, and rates of depression, physical functioning, and perceived stigma.
Results. Having the FSS was associated with perceived stigma in CFS compared to the medical control group, and remained an independent predictor when controlling for depression and physical functioning on multivariate analysis. These effects were not seen in FM or IBS compared to medical control groups.
Conclusions. The ambiguity of having a medically unexplained syndrome may contribute to perceived stigma in CFS. The absence of this effect in FM and IBS may reflect a greater acceptance of FM and IBS as medical conditions.
Moore, Rick A. "Measuring the Impact of Recognized Patient-Centered Medical Homes (PCMH)". Thesis, Virginia Commonwealth University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=3746418.
Testo completoIt has been estimated that by 2020 nearly one-third of all Americans (almost 160 million people) will have at least one chronic disease to manage and the cost of health care will consume over 20 percent of the GDP. The Obama Administration responded to this pending crisis by passing the Patient Protection and Affordable Care Act (PPACA) in 2010. This major legislation aims to instill patient-centered, accountable care into the health care delivery system. Specifically, the United States government is on a mission to reduce the utilization of expensive inpatient care, while increasing access to primary care for all Americans, thereby lowering the total cost of health care.
Primary care practices organized around the principles of the patient-centered medical home (PCMH) can better manage their patients, especially their patients with chronic conditions; and become accountable for their care. In 2008, the National Committee for Quality Assurance (NCQA) released practice-level recognition standards based on the seven Joint Principles of the PCMH, to aid doctors seeking to transform their practices into effective patient-centered delivery systems.
The results of several published studies have touted the successes (e.g., reduced emergency department visits, reduced hospitalizations) of the PCMH model at individual practice sites. These localized successes demonstrated that the principle tenets of the PCMH model—care coordination, team-based care, population management—helped lower utilization of more expensive health care services within the specific practice settings evaluated. However, there has been no study to determine if these core tenets are having a broader impact on the health care delivery system within a community.
One hypothesized outcome of a health care system centered on the PCMH care model is better care coordination and more effective, whole-person care management across the continuum of health care; resulting in a more efficient system that can prevent avoidable hospitalizations.
This dissertation proposal seeks to understand if the increasing numbers (density) of recognized PCMH practices in communities affect avoidable hospitalizations related to ambulatory care sensitive conditions (ACSC), as measured by the AHRQ Composite Prevention Quality Indicators (PQI). The research has two purposes:
1. Establish constructs and hypotheses to measure the effect of the increasing numbers of NCQA-Recognized PCMH practices in communities (counties).
2. Using an outcomes-based measurement approach, investigate the relationship between growing densities of NCQA-Recognized PCMH practice doctors among all primary care doctors (PCD) in a community and the associated impact on the utilization of inpatient care, specifically related to ACSCs, as measured by the AHRQ Composite PQIs.
The research is quasi-experimental in design and is based on a retrospective (2008–2011) analysis of existing data from the NCQA PCMH program, the AHRQ Composite PQI and the Centers for Medicare & Medicaid Services (CMS) National Provider Identification (NPI) databases. Analysis will link NCQA-Recognized PCMH practices (independent variable), AHRQ Risk Adjusted Composite PQIs (dependent variable), and the CMS NPI (total PCDs) on Federal Information Processing Standard (FIPS) identifiers across 114 state and county-level geographical areas in Vermont and North Carolina. The research will inform the following hypotheses:
1. Does the research literature support the measurement construct proposed in this study?
2. Communities with concentrations of recognized PCMH practices among primary care practices will have lower risk-adjusted avoidable hospital admission rates.
3. The use of technology and care coordination will have a greater predictive correlation on risk-adjusted avoidable hospital admission rates than other PCMH capabilities.
Cooke, Natalie Kathleen. "Assessing Future Healthcare Providers' Views of Childhood Obesity to Inform Premedical and Medical Curricular Changes". Thesis, North Carolina State University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3584005.
Testo completoChildhood obesity is a disease that affects 17% of children aged 2-19. This disease, best described by a social ecological perspective, is multifactorial in nature and includes individual, familial, community, and societal contributors. As the causes are multifactorial, so too should be prevention and treatment. Healthcare providers, specifically physicians, can play an important role in the diagnosis, prevention, and treatment of childhood obesity, especially if they appropriately utilize nutrition behavior change counseling to facilitate lifestyle changes. Behavior change falls within the realm of the social and behavioral sciences, disciplines that will receive greater emphasis on the newly designed MCAT 2015®; therefore, premedical and medical programs may need to alter their approaches to disseminating this discipline-specific knowledge. Nutrition education is currently limited in medical education; and thus, just as premedical programs seek to increase the social and behavioral sciences, so too should they increase nutrition education. In light of these recommended curricular changes, researchers sought to investigate the current state of premedical and medical students. views of childhood obesity. This dissertation describes three studies conducted for that purpose. In study 1, researchers investigated 30 pre-healthcare undergraduate seniors. views of childhood obesity and their sources of knowledge through in-depth qualitative interviews. Investigators found that students with specialized coursework and significant volunteer and/or internship experience had a deeper understanding of childhood obesity; however, as a whole, students failed to see the role of healthcare providers in prevention and treatment. These findings provide justification for premedical programs to guide students to see their role in prevention and treatment through educating them on the social ecological model and providing them with relevant service-learning opportunities and guided reflection. In study 2, researchers conducted a similar nationwide qualitative investigation in 78 third and fourth year medical students. These students described student-, patient- and healthcare system-centered barriers, including their lack of knowledge, patients. lack of access, and their lack of time in practice. Students also requested more applicable information and counseling training in order to equip them to prevent and treat childhood obesity. Much like the pre-healthcare seniors, these medical students failed to discuss their role in prevention and treatment. Therefore, medical schools need to help their students overcome barriers by providing them knowledge and skills and helping them understand their role in prevention and treatment. In study 3, researchers built on the knowledge gained from study 1 and study 2 and developed a valid and reliable computerized tool, the Childhood Obesity Prevention Self-efficacy (COP-SE) survey. Factor analysis of 444 completed surveys from students at 53 medical schools revealed a two factor structure with a correlation of 0.637 between factors. Factor 1 assesses self-efficacy in nutrition counseling while Factor 2 measures self-efficacy to assess readiness to change and initiate nutrition lifestyle changes. There was high reliability within factors (Factor 1 = 0.946; Factor 2 = 0.927), and the correlation (0.648) between the COP-SE survey and a general self-efficacy survey confirmed that the COP-SE measures domain-specific self-efficacy. This valid and reliable survey can be used by medical schools as a formative or summative assessment of students. self-efficacy in childhood obesity prevention and treatment. Further research should include confirming the factor structure and exploring the significance of response trends seen in this sample. The findings of all three studies can be used by premedical and medical programs to maximize the effectiveness of their preparatory programs to provide students with the necessary skills for prevention and treatment of childhood obesity. With the appropriate preparation, future healthcare providers can build their self-efficacy in disease prevention and treatment, hopefully resulting in improved patient outcomes.
Frödin, Ulla. "Health-related quality of life during and after stem cell transplantation". Licentiate thesis, Linköpings universitet, Omvårdnad, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-92806.
Testo completoFrisby, Anthony J. "Self-directed learning readiness in medical students at the Ohio State University /". The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487688507502934.
Testo completoTomasa, Lynne Tokie. "Family medicine in the academic medical enterprise: Issues of resource dependence, culture, and professionalization". Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282705.
Testo completoKovach, Alison A. "Challenges of Medical Laboratory Science and Medical Laboratory Technology Program Directors". Youngstown State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1433424508.
Testo completoDriesen, Kevin E. "Statistical process control as quantitative method to monitor and improve medical quality". Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/280602.
Testo completoKhan, Ayaz, e Muhammad Haidar Zaman. "Mutagenesis of a Dengue virus replicon by introducing stop codons within NS5". Thesis, Södertörns högskola, Institutionen för naturvetenskap, miljö och teknik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-28645.
Testo completoKozinetz, Claudia A. "Anatomy of the Medical Literature". Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/1499.
Testo completoEyoh, Unyime. "Polypharmacy, the Electronic Medical Record, and Adverse Drug Events". ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2535.
Testo completoSanghavi, Prachi. "Is Doing More, Doing Better? Basic Versus Advanced Life Support Ambulances for Medical Emergencies". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467334.
Testo completoHealth Policy
Orwelius, Lotti. "Health related quality of life in adult former intensive care unit patients". Doctoral thesis, Linköpings universitet, Institutionen för medicin och hälsa, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17829.
Testo completoRussell, Botimi. "Young women's views on mental health and the use of social media". Thesis, Mälardalens högskola, Akademin för hälsa, vård och välfärd, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-41766.
Testo completoJohannesson, Eva. "Learning manual and procedural clinical skills through simulation in health care education". Licentiate thesis, Linköpings universitet, Sjukgymnastik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-75505.
Testo completoWang, Tongtong. "Methodological issues in the assessment of the safety of medical cannabis". Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=92202.
Testo completoThis thesis seeks to improve our understanding of the safety of medical cannabis use. Existing safety information was first assessed in a meta-analysis of all cannabinoid RCTs and a separate systematic review of recreational cannabis. Following this, a prospective cohort study [Cannabis for the Management of Pain, Assessment of Safety Study (COMPASS)] was then conducted. A total of 215 subjects (chronic pain patients who used cannabis provided by Health Canada in the study) and 216 controls (who did not use cannabis) were recruited from across Canada. Adverse events were collected over a one-year period to assess the safety of herbal cannabis for the treatment of chronic pain. In considering the most efficient strategy to control for potential confounders in the development of COMPASS, the statistical efficiency of matching and a multiple model with an adjustment for confounders were compared in a separate project.
This thesis improves our knowledge about adverse events associated with medical cannabis (pharmaceutical cannabinoid products and herbal cannabis), and contributes to the discussion concerning its therapeutic uses from a safety point of view. The consistency of results from our meta-analysis and the COMPASS study allows us to more firmly conclude that medical cannabis was associated with an increased risk of non-serious adverse events (AEs), in particular in relation to the nervous system and psychiatric disorders, compared to controls. However, the evidence regarding the presence or absence of a potential risk of serious adverse events, among patients on cannabis compared with controls, is inconclusive because the study lacks power.
In conclusion, the results suggest the adverse effects of medical cannabis among experienced users are modest. Further studies with systematic long-term follow-up are required to characterize safety issues among new cannabis users and the risk of serious adverse events.
L'utilisation accrue du cannabis pour des besoins thérapeutiques soulève des questions sur son innocuité; et pourtant, aucune étude épidémiologique n'a été conduite pour évaluer cette innocuité. L'information disponible vient essentiellement, d'études observationnelles d'utilisation du cannabis dans le cadre d'un usage récréatif, ou d'essais cliniques randomisés qui ont comme principal objectif l'évaluation de l'efficacité d'un produit.
Cette thèse cherche à améliorer notre connaissance sur l'innocuité du cannabis pour usage médical. L'information disponible a été initialement utilisée dans le cadre d'une méta-analyse des essais cliniques randomisés sur les cannabinoïdes et ensuite dans le cadre d'une revue systématique des études observationnelles sur l'utilisation du cannabis dans le cadre d'un usage récréatif. Par la suite, une étude de cohorte prospective [Cannabis for the Management of Pain, Assessment of Safety Study (COMPASS)] a été menée. Dans le cadre de cette étude, un total de 215 sujets (des patients ayant une douleur chronique et qui ont utilisé le cannabis fourni dans le cadre du programme de Santé Canada) ainsi que 216 contrôles (des gens avec douleur chrnonique qui n'ont pas utilisé de cannabis) ont été recrutés à travers tout le Canada. Les effets indésirables ont été collectés sur une période d'une année pour évaluer l'innocuité du cannabis. En cherchant la meilleure stratégie pour contrôler les facteurs confondants, dans le cadre de l'étude COMPASS, l'efficience statistique de l'appariement (matching) et du modèle multiple (multiple model) avec ajustement pour les facteurs confondants a été examinée dans un projet séparé. fr
Cette thèse améliore nos connaissances concernant les effets indésirables associés à l'utilisation du cannabis à des fins médicales (cannabinoïdes pharmaceutiques et les feuilles de cannabis), et contribue à la discussion concernant l'usage thérapeutique du cannabis d'un point de vue de son innocuité. La concordance des résultats de notre méta-analyse et de ceux de l'étude COMPASS nous permet de conclure, en comparaison avec le groupe contrôle, l'utilisation du cannabis pour des besoins thérapeutiques est associée à un risque accrue d'effets indésirables moins sévères, en particulier ceux relatifs au système nerveux et aux désordres psychiatriques. Cependant, comparativement au groupe de contrôle, les résultats relatifs au risque potentiel d'effets indésirables sérieux chez les patients exposés au cannabis sont non concluants. fr
En conclusion, les résultats de notre étude suggèrent que les effets indésirables sont minimes parmi les utilisateurs de longue durée du cannabis. D'autres études ayant une période de suivi plus longue sont nécessaires pour déterminer l'innocuité du cannabis parmi les nouveaux utilisateurs et le risque d'effets indésirables graves. fr
Toufani, Tina. "A systematic review of health problemsfollowing tsunamis". Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-73273.
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