Articoli di riviste: "Magnetic dual-modal probes"

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Chen, Bing Di, Tian Zhou, Bo Zhang e Ai Hua Yao. "Novel Single Walled Carbon Nanotube Based Magnetic-Fluorescent Nanohybrids as Dual-Modal MRI/Optical Imaging Probes". Advanced Materials Research 476-478 (febbraio 2012): 1134–37. http://dx.doi.org/10.4028/www.scientific.net/amr.476-478.1134.

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Gadolinium chelate and Quantum Dots (QDs) decorated single walled carbon nanotubes (SWNTs) nanohybrids (SWNT-Gd-QDs) were designed for dual-modal cellular imaging via magnetic resonance imaging (MRI) and optical imaging. The nanohybrids were prepared via a simple and novel layer-by-layer (LBL) assembly in combination with covalent connection strategy. The SWNT-Gd-QDs nanohybrids showed a strong near-infrared photoluminescence (PL) emission at room temperature and enhanced T1-weighted and T2-weighted MRI signals in water. Thus, the nanohybrids combine magnetic and fluorescent properties and can serve as dual-modal MRI/optical imaging contrast agent.

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Zhu, Qin, Fei Pan, Yu Tian, Weijun Tang, Yuan Yuan e Aiguo Hu. "Facile synthesis of Gd(iii) metallosurfactant-functionalized carbon nanodots with high relaxivity as bimodal imaging probes". RSC Advances 6, n. 35 (2016): 29441–47. http://dx.doi.org/10.1039/c6ra02654k.

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Liu, Ping, e Wei Miu. "Hydrothermal synthesis of BaYbF5:Tm3+ nanoparticles for dual-modal upconversion near-infrared luminescence and magnetic resonance imaging". Functional Materials Letters 09, n. 03 (giugno 2016): 1650038. http://dx.doi.org/10.1142/s1793604716500387.

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In this paper, we demonstrate multifunctional upconversion nanoparticles with intense near-infrared emission and unique magnetic properties for dual-modal upconversion luminescent bioimaging and T2-weighted magnetic resonance imaging. High-quality BaYbF5:Tm3+ nanoparticles are synthesized via a hydrophobic method and then converted to be hydrophilic via a hydrochloric acid treatment. The as-synthesized nanoparticles are cubic phase and about 6 nm in diameter with narrow size distribution. The intense near-infrared emission makes these nanoparticles can be acted as bio-probes in upconversion luminescent bioimaging with deep tissue penetration. Besides, these nanoparticles can also be used as T2-weighted contrast agents in magnetic resonance imaging due to the high value of relaxation rate (r2 = 4.05) in 0.55 T. This finding may have further bio-applications in the future due to the high performance of these BaYbF5:Tm3+ nanoparticles in dual-modal bioimaging.

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Stasiuk, Graeme J., Florencia Minuzzi, Myra Sae-Heng, Charlotte Rivas, Hans-Paul Juretschke, Lorenzo Piemonti, Peter R. Allegrini et al. "Dual-Modal Magnetic Resonance/Fluorescent Zinc Probes for Pancreatic β-Cell Mass Imaging". Chemistry - A European Journal 21, n. 13 (3 marzo 2015): 5023–33. http://dx.doi.org/10.1002/chem.201406008.

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Gao, Ai, Dan Zhang e Xue-Bo Yin. "Near infrared fluorescence-magnetic resonance dual-modal imaging with Cy5-labeled, Gd–Al co-doped mesoporous silica nanoparticles". Analytical Methods 8, n. 1 (2016): 214–21. http://dx.doi.org/10.1039/c5ay02230d.

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We report a reliable and facile procedure to prepare near infrared fluorescence (NIRF)-magnetic resonance dual-modal imaging probes (DMIPs) using Cy5-labeled, Gd–Al co-doped mesoporous silica nanoparticles. High intensity NIRF and a relaxation rate (17.7 mM⁻¹s⁻¹) can be observed. Furthermore, the DMIPs in saline were injected into mice through the tail vein for imaging.

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Fei-Peng, Zhu, Chen Guo-Tao, Wang Shou-Ju, Liu Ying, Tang Yu-Xia, Tian Ying, Wang Jian-Dong et al. "Dual-Modality Imaging Probes with High Magnetic Relaxivity and Near-Infrared Fluorescence Based Highly Aminated Mesoporous Silica Nanoparticles". Journal of Nanomaterials 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/6502127.

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Dual-modal imaging by combining magnetic resonance (MR) and near-infrared (NIR) fluorescence can integrate the advantages of high-resolution anatomical imaging with high sensitivity in vivo fluorescent imaging, which is expected to play a significant role in biomedical researches. Here we report a dual-modality imaging probe (NIR/MR-MSNs) fabricated by conjugating NIR fluorescent heptamethine dyes (IR-808) and MR contrast agents (Gd-DTPA) within highly aminated mesoporous silica nanoparticles (MSNs-NH2). The dual-modality imaging probes NIR/MR-MSNs possess a size of ca. 120 nm. The NIR/MR-MSNs show not only near-infrared fluorescence imaging property with an emission peak at 794 nm, but also highly MRT1relaxivity of 14.54 mM−1 s−1, which is three times more than Gd-DTPA. In vitro experiment reveals high uptake and retention abilities of the nanoprobes, while cell viability assay demonstrates excellent cytocompatibility of the dual-modality imaging probe. After intratumor injection with the NIR/MR-MSNs, MR imaging shows clear anatomical border of the enhanced tumor region while NIR fluorescence exhibits high sensitive tumor detection ability. These intriguing features suggest that this newly developed dual-modality imaging probes have great potential in biomedical imaging.

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Li, Dongdong, Wenzhi Song, Dezhou Wang, Shengyang Qi, Kaishen Li e Wanzhong Yin. "AIEgens functionalized gadolinium-based aminoclay as dual-modal probes for fluorescence and magnetic resonance imaging". Inorganic Chemistry Communications 95 (settembre 2018): 32–35. http://dx.doi.org/10.1016/j.inoche.2018.07.003.

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Li, Kai, Dan Ding, Da Huo, Kan-Yi Pu, Ngo Nguyen Phuong Thao, Yong Hu, Zhi Li e Bin Liu. "Conjugated Polymer Based Nanoparticles as Dual-Modal Probes for Targeted In Vivo Fluorescence and Magnetic Resonance Imaging". Advanced Functional Materials 22, n. 15 (30 aprile 2012): 3107–15. http://dx.doi.org/10.1002/adfm.201102234.

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Liu, Chunyan, Zhenyu Gao, Jianfeng Zeng, Yi Hou, Fang Fang, Yilin Li, Ruirui Qiao et al. "Magnetic/Upconversion Fluorescent NaGdF4:Yb,Er Nanoparticle-Based Dual-Modal Molecular Probes for Imaging Tiny Tumors in Vivo". ACS Nano 7, n. 8 (26 luglio 2013): 7227–40. http://dx.doi.org/10.1021/nn4030898.

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Baziulyte-Paulaviciene, Dovile, Vitalijus Karabanovas, Marius Stasys, Greta Jarockyte, Vilius Poderys, Simas Sakirzanovas e Ricardas Rotomskis. "Synthesis and functionalization of NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles for possible application as multimodal contrast agents". Beilstein Journal of Nanotechnology 8 (1 settembre 2017): 1815–24. http://dx.doi.org/10.3762/bjnano.8.183.

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Upconverting nanoparticles (UCNPs) are promising, new imaging probes capable of serving as multimodal contrast agents. In this study, monodisperse and ultrasmall core and core–shell UCNPs were synthesized via a thermal decomposition method. Furthermore, it was shown that the epitaxial growth of a NaGdF4 optical inert layer covering the NaGdF4:Yb,Er core effectively minimizes surface quenching due to the spatial isolation of the core from the surroundings. The mean diameter of the synthesized core and core–shell nanoparticles was ≈8 and ≈16 nm, respectively. Hydrophobic UCNPs were converted into hydrophilic ones using a nonionic surfactant Tween 80. The successful coating of the UCNPs by Tween 80 has been confirmed by Fourier transform infrared (FTIR) spectroscopy. Scanning electron microscopy (SEM), powder X-ray diffraction (XRD), photoluminescence (PL) spectra and magnetic resonance (MR) T1 relaxation measurements were used to characterize the size, crystal structure, optical and magnetic properties of the core and core–shell nanoparticles. Moreover, Tween 80-coated core–shell nanoparticles presented enhanced optical and MR signal intensity, good colloidal stability, low cytotoxicity and nonspecific internalization into two different breast cancer cell lines, which indicates that these nanoparticles could be applied as an efficient, dual-modal contrast probe for in vivo bioimaging.

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Marasini, Shanti, Huan Yue, Adibehalsadat Ghazanfari, Son Long Ho, Ji Ae Park, Soyeon Kim, Hyunsil Cha et al. "Polyaspartic Acid-Coated Paramagnetic Gadolinium Oxide Nanoparticles as a Dual-Modal T1 and T2 Magnetic Resonance Imaging Contrast Agent". Applied Sciences 11, n. 17 (4 settembre 2021): 8222. http://dx.doi.org/10.3390/app11178222.

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Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of the nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd2O3 nanoparticles with an average particle diameter of 2.0 nm were synthesized using the one-pot polyol method. The synthesized nanoparticles exhibited r1 and r2 of 19.1 and = 53.7 s−1mM−1, respectively, (r1 and r2 are longitudinal and transverse water–proton spin relaxivities, respectively) at 3.0 T MR field, approximately 5 and 10 times higher than those of commercial Gd-chelate contrast agents, respectively. The T1 and T2 MR images could be obtained due to an appreciable r2/r1 ratio of 2.80, indicating their potential as a dual-modal T1 and T2 MRI contrast agent.

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Xie, Ruoxi, Zijun Wu, Fanxin Zeng, Huawei Cai, Dan Wang, Lei Gu, Hongyan Zhu et al. "Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma". Signal Transduction and Targeted Therapy 6, n. 1 (19 agosto 2021). http://dx.doi.org/10.1038/s41392-021-00724-y.

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AbstractGlioblastoma (GBM), one of the most common primary intracranial malignant tumours, is very difficult to be completely excised by surgery due to its irregular shape. Here, we use an MRI/NIR fluorescence dual-modal imaging nanoprobe that includes superparamagnetic iron oxide nanoparticles (SPIONs) modified with indocyanine (Cy7) molecules and peptides (ANG or DANG) to locate malignant gliomas and guide accurate excision. Both peptides/Cy7-SPIONs probes displayed excellent tumour-homing properties and barrier penetrating abilities in vitro, and both could mediate precise aggregation of the nanoprobes at gliomas sites in in vivo magnetic resonance imaging (MRI) and ex vivo near-infrared (NIR) fluorescence imaging. However, compared with ANG/Cy7-SPIONs probes, DANG/Cy7-SPIONs probes exhibited better enhanced MR imaging effects. Combining all these features together, this MRI/NIR fluorescence imaging dual-modal nanoprobes modified with retro-enantio isomers of the peptide have the potential to accurately display GBMs preoperatively for precise imaging and intraoperatively for real-time imaging.

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Nakanishi, Yusuke, Masataka Nagata, Hirotoshi Yasui e Kazuhide Sato. "Gd-Encapsulated Carbon Nanotubes as Dual-Modal Probes for Magnetic Resonance and Second Near-Infrared Emission". ECS Journal of Solid State Science and Technology, 31 agosto 2022. http://dx.doi.org/10.1149/2162-8777/ac8e2f.

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Abstract We report a near-infrared (NIR) fluorescence and magnetic resonance (MR) dual-modal probe composed of fluorescent carbon nanotubes (CNTs) filled with paramagnetic Gd ions. The Gd-filled CNTs are synthesized by means of a vapor-phase technique using gadolinium halides as precursors, and host CNTs exhibit the strong photoluminescence even after Gd filling. We have investigated the NIR fluorescence and MR imaging in vivo as well as in vitro, and demonstrated that the Gd-filled CNTs can be used for the dual-modal imaging of tissues and vessels in the living mice.

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Dong, Yansong, Ye Liu, Yalan Tu, Youyong Yuan e Jun Wang. "AIEgens Cross‐Linked Iron Oxide Nanoparticles Synchronously Amplify Bimodal Imaging Signals in Situ by Tumor Acidity‐Mediated Click Reaction". Angewandte Chemie International Edition, 11 novembre 2023. http://dx.doi.org/10.1002/anie.202310975.

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Activatable dual‐modal molecular imaging probes present a promising tool for the diagnosis of malignant tumors. However, synchronously enhancing dual‐modal imaging signals under a single stimulus is challenging. Herein, we propose an activatable bimodal probe that integrates aggregation‐induced emission luminogens (AIEgens) and iron oxide nanoparticles (IOs) to synergistically enhance near‐infrared fluorescence (NIRF) intensity and magnetic resonance (MR) contrast through a tumor acidity‐mediated click reaction. Tumor acidity‐responsive IOs containing dibenzocyclooctyne groups (termed cDIOs) and AIEgens containing azide groups (termed AATs) can be covalently cross‐linked in response to tumor acidity, which leads to a simultaneous enhancement in NIRF intensity (~12.4‐fold) and r2 relaxivity (~2.8‐fold). cDIOs and AATs were effective activated in mice orthotropic breast tumor, and the cross‐linking prolonged their retention in tumor, further augmenting the bimodal signals and expanding imaging time frame. This facile strategy leverages the inherent properties of probes themselves and demonstrates promise in future translational studies.

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Dong, Yansong, Ye Liu, Yalan Tu, Youyong Yuan e Jun Wang. "AIEgens Cross‐Linked Iron Oxide Nanoparticles Synchronously Amplify Bimodal Imaging Signals in Situ by Tumor Acidity‐Mediated Click Reaction". Angewandte Chemie, 11 novembre 2023. http://dx.doi.org/10.1002/ange.202310975.

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Abstract (sommario):

Activatable dual‐modal molecular imaging probes present a promising tool for the diagnosis of malignant tumors. However, synchronously enhancing dual‐modal imaging signals under a single stimulus is challenging. Herein, we propose an activatable bimodal probe that integrates aggregation‐induced emission luminogens (AIEgens) and iron oxide nanoparticles (IOs) to synergistically enhance near‐infrared fluorescence (NIRF) intensity and magnetic resonance (MR) contrast through a tumor acidity‐mediated click reaction. Tumor acidity‐responsive IOs containing dibenzocyclooctyne groups (termed cDIOs) and AIEgens containing azide groups (termed AATs) can be covalently cross‐linked in response to tumor acidity, which leads to a simultaneous enhancement in NIRF intensity (~12.4‐fold) and r2 relaxivity (~2.8‐fold). cDIOs and AATs were effective activated in mice orthotropic breast tumor, and the cross‐linking prolonged their retention in tumor, further augmenting the bimodal signals and expanding imaging time frame. This facile strategy leverages the inherent properties of probes themselves and demonstrates promise in future translational studies.

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Yu, Cheng, Zhuyuan Ding, Huan Liu, Yulu Ren, Minping Zhang, Qiuling Liao, Tao Luo et al. "Novel albumin-binding multifunctional probe for synergistic enhancement of FL/MR dual-modal imaging and photothermal therapy". Frontiers in Chemistry 11 (1 agosto 2023). http://dx.doi.org/10.3389/fchem.2023.1253379.

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The fluorescence/magnetic resonance (FL/MR) dual-modal imaging could provide accurate tumor visualization to guide photothermal therapy (PTT) of cancer, which has attracted widespread attention from scientists. However, facile and effective strategies to synergistically enhance fluorescence intensity, MR contrast and photothermal efficacy have rarely been reported. This study presents a novel multifunctional probe Gd-EB-ICG (GI) for FL/MR dual-modal imaging-guided PTT of cancer. GIs can self-assemble with endogenous albumin to form drug-albumin complexes (GIAs), which exhibit excellent biocompatibility. Albumin can protect GIAs from the recognition and clearance by the mononuclear phagocytic system (MPS). High plasma concentration and long half-life allow GIAs to accumulate continuously in the tumor area through EPR effect and specific uptake of tumor. Because of the prolonged rotational correlation time (τR) of Gd chelates, GIAs exhibited superior MR contrast performance over GIs with more than 3 times enhancement of longitudinal relaxation efficiency (r1). The fluorescence quantum yield and photothermal conversion efficiency of GIAs was also significantly improved due to the constrained geometry, disrupted aggregation and enhanced photothermal stability. This simple and feasible strategy successfully resulted in a synergistic effect for FL/MR dual-modal imaging and photothermal therapy, which can cast a new light for the clinical translation of multifunctional probes.

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Zhang, Ya’nan, Lu Liu, Wenling Li, Caiyun Zhang, Tianwei Song, Peng Wang, Daxi Sun et al. "PDGFB-targeted functional MRI nanoswitch for activatable T1–T2 dual-modal ultra-sensitive diagnosis of cancer". Journal of Nanobiotechnology 21, n. 1 (6 gennaio 2023). http://dx.doi.org/10.1186/s12951-023-01769-7.

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AbstractAs one of the most significant imaging modalities currently available, magnetic resonance imaging (MRI) has been extensively utilized for clinically accurate cancer diagnosis. However, low signal-to-noise ratio (SNR) and low specificity for tumors continue to pose significant challenges. Inspired by the distance-dependent magnetic resonance tuning (MRET) phenomenon, the tumor microenvironment (TME)-activated off–on T1–T2 dual-mode MRI nanoswitch is presented in the current study to realize the sensitive early diagnosis of tumors. The tumor-specific nanoswitch is designed and manufactured on the basis of PDGFB-conjugating ferroferric oxide coated by Mn-doped silica (PDGFB-FMS), which can be degraded under the high-concentration GSH and low pH in TME to activate the T1–T2 dual-mode MRI signals. The tumor-specific off–on dual-mode MRI nanoswitch can significantly improve the SNR and is used successfully for the accurate diagnosis of early-stage tumors, particularly for orthotopic prostate cancer. In addition, the systemic delivery of the nanoswitch did not cause blood or tissue damage, and it can be excreted out of the body in a timely manner, demonstrating excellent biosafety. Overall, the strategy is a significant step in the direction of designing off–on dual-mode MRI nanoprobes to improve imaging accuracy, which opens up new avenues for the development of new MRI probes.

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Huang, Rui, Yi Zhou, Jiaxiang Hu, An Peng e Weihao Hu. "Deep learning-assisted multicolor fluorescent probes for Image and Spectral dual-modal identification of illicit drugs". Sensors and Actuators B: Chemical, luglio 2023, 134348. http://dx.doi.org/10.1016/j.snb.2023.134348.

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Wang, Shuhan, Xuan Zhang, Yiping Zhang, Kang Zhu, Xing Liu, Jieping Zhang, Guoyu Wang et al. "Activatable Nanoprobes for Dual‐Modal NIR‐II Photoacoustic and Fluorescence Imaging of Hydrogen Sulfide in Colon Cancer". Advanced Optical Materials, 26 dicembre 2023. http://dx.doi.org/10.1002/adom.202302796.

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AbstractHigh hydrogen sulfide (H2S) expression has been shown to play a crucial role in tumor growth and proliferation in colon cancer. So far, most probes used for monitoring H2S offer single‐modal imaging, which makes the collection of accurate information for tumor diagnosis difficult. In the present study, a novel dual‐modal imaging probe in the second near‐infrared (NIR‐II, 950‐1700) window is proposed and constructed by coating a uniform shell of polydopamine (PDA) on the surface of cuprous oxide (Cu2O)‐conjugated downconversion nanoparticles (DCNPs). Of note, DCNP‐Cu2O@PDA is in the “on” state, with emission centered at 1550 nm (irradiation using a 980nm laser) in non‐neoplastic tissues. Colon tumors with endogenous H2S overexpression can induce the in situ transformation of Cu2O to copper sulfide (Cu2‐XS）. Owing to the competitive absorption between Cu2‐XS and DCNPs at a wavelength of 980 nm, the generated DCNP‐Cu2‐XS@PDA exhibits a quenched NIR‐II fluorescence (FL) signal. Meanwhile, Cu2‐XS exhibits a strong absorbance at 1250 nm, enhancing the NIR‐II photoacoustic (PA) signal accompanied by NIR‐II FL attenuation. The switching in PA and FL signals at the tumor site offered “double assurances” for the accurate monitoring of H2S.

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Wei, Zhuxin, Guangxin Duan, Baoxing Huang, Shanshan Qiu, Dandan Zhou, Jianfeng Zeng, Jiabin Cui et al. "Rapidly liver-clearable rare-earth core–shell nanoprobe for dual-modal breast cancer imaging in the second near-infrared window". Journal of Nanobiotechnology 19, n. 1 (17 novembre 2021). http://dx.doi.org/10.1186/s12951-021-01112-y.

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Abstract Background Fluorescence imaging as the beacon for optical navigation has wildly developed in preclinical studies due to its prominent advantages, including noninvasiveness and superior temporal resolution. However, the traditional optical methods based on ultraviolet (UV, 200–400 nm) and visible light (Vis, 400–650 nm) limited by their low penetration, signal-to-noise ratio, and high background auto-fluorescence interference. Therefore, the development of near-infrared-II (NIR-II 1000–1700 nm) nanoprobe attracted significant attentions toward in vivo imaging. Regrettably, most of the NIR-II fluorescence probes, especially for inorganic NPs, were hardly excreted from the reticuloendothelial system (RES), yielding the anonymous long-term circulatory safety issue. Results Here, we develop a facile strategy for the fabrication of Nd3+-doped rare-earth core–shell nanoparticles (Nd-RENPs), NaGdF4:5%Nd@NaLuF4, with strong emission in the NIR-II window. What’s more, the Nd-RENPs could be quickly eliminated from the hepatobiliary pathway, reducing the potential risk with the long-term retention in the RES. Further, the Nd-RENPs are successfully utilized for NIR-II in vivo imaging and magnetic resonance imaging (MRI) contrast agents, enabling the precise detection of breast cancer. Conclusions The rationally designed Nd-RENPs nanoprobes manifest rapid-clearance property revealing the potential application toward the noninvasive preoperative imaging of tumor lesions and real-time intra-operative supervision. Graphical abstract

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Hao, Jiaqi, Huawei Cai, Lei Gu, Yiqi Ma, Yan Li, Beibei Liu, Hongyan Zhu, Fanxin Zeng e Min Wu. "A transferrin receptor targeting dual-modal MR/NIR fluorescent imaging probe for glioblastoma diagnosis". Regenerative Biomaterials, 17 febbraio 2024. http://dx.doi.org/10.1093/rb/rbae015.

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Abstract The prognosis of glioblastoma (GBM) remains challenging, primarily due to the lack of a precise, effective imaging technique for comprehensively characterization. Addressing GBM diagnostic challenges, our study introduces an innovative dual-modal imaging that merges near-infrared (NIR) fluorescent imaging with magnetic resonance imaging (MRI). This method employs superparamagnetic iron oxide nanoparticles (SPIONs) coated with NIR fluorescent dyes, specifically Cyanine 7 (Cy7), and targeted peptides. This synthetic probe facilitate MRI functionality through SPIONs, provides NIR imaging capability via Cy7, and enhances tumor targeting trough peptide interactions, offering a comprehensive diagnostic tool for GBM. Notably, the probe traverses the blood-brain barrier (BBB), targeting GBM in vivo via peptides, producing clear and discernible images in both modalities. Cytotoxicity and histopathology assessments confirm the probe's favorable safety profile. These findings suggest that the dual-modal MR\NIR fluorescent imaging probe could revolutionize GBM prognosis and survival rates, which can also be extended to other tumors type.

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Jiang, Xiaoping, Yue Guo, Lixi Wang e Qitu Zhang. "Dynamic photoluminescent and photochromic properties of CaAl12O19:Eu, Tb: A novel phosphor for advanced dual-modal multicolor anticounterfeiting". Ceramics International, ottobre 2023. http://dx.doi.org/10.1016/j.ceramint.2023.09.325.

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