Tesi sul tema "Mạc family"
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Jopling, Catherine L. "Internal ribosome entry in the myc gene family". Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/29662.
Testo completoBull, Camilla Louise. "Localisation and expression of epididymal apical protein I". Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319142.
Testo completoFoster, Helen Elisabeth. "A family study of primary Sjogren's syndrome in north east England". Thesis, University of Newcastle Upon Tyne, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309065.
Testo completoLiang, Rebecca Yue. "Probing Protein Interactions with Stapled Peptides: Myc Family and Insulin Receptor". Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11063.
Testo completoChemistry and Chemical Biology
Lee, Sun Young. "The search for Myc-family genes in lepidopteran insects, strategies and applications". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq62172.pdf.
Testo completoRice, Jerome Lee. "Examining Family Hierarchy Through the Eyes of Former Mac Baller Gang Members". ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7952.
Testo completoRyan, Sarra Louise. "The clinical and biological roles of MYC gene family amplification in childhood medulloblastoma". Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.512113.
Testo completoKoneni, Rupa. "The Biological Function of Interacting Partners of ZXD Family Proteins". Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1250261050.
Testo completoPELLANDA, PAOLA. "STRUCTURE-FUNCTION ANALYSIS OF MYC/MAX-DNA BINDING". Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/556180.
Testo completoSu, Yingtao. "Function and regulation of myc-family bHLHZip transcription factors during the animal and plant cell cycle /". Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2008. http://epsilon.slu.se/200836.pdf.
Testo completoBowen, Holly. "Characterisation of the solute carrier family member 11al (Slc11al) promoter : regulation by c-Myc and miz-1". Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274540.
Testo completoKristiansen, Ole Peter. "Non-MHC genes in type 1 diabetes : family-based association studies and functional studies of disease-associated polymorphisms /". København : Lægeforeningens forl, 2005. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014653439&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Testo completoBiella, Andrea Alexandra do Amaral Silva e. "Famílias no museu de arte: lazer e conhecimento: um estudo sobre o programa educativo Interar-te do MAC USP". Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/48/48134/tde-29052012-135440/.
Testo completoThe research Families in the museum of art: leisure and knowledge a study about the Interar-te Educational Program from MAC USP aims to investigate the motivation of adults who provide their children with cultural and educational activities during their families leisure time, in order to observe the impact of these initiatives on the habit of attending museums of art among these family members. A program called Interar-te, which is developed by the Museum of Contemporary Art of the University of São Paulo (MAC USP), was chosen for this case study. This Program, whose target audience is directed to parents and their children, is held once a month, on Saturdays, between January and November, and is one of the university extension activities provided by the Technical-Scientific Division of Education and Art of MAC USP. It was created to supply an institutional demand of the Museums headquarters, located at Ibirapuera Park, which is a park that receives lots of visitors on weekends because of the leisure options it offers. The concepts of leisure and family were approached, and the principles related to education in art museums were approached in order to provide a better comprehension of the research context. The research was based on methodologies for qualitative research analysis, and other complementary information was collected by using quantitative tools, which were directed to the sample selected for the study. Considering the delimitation of the sample profile, we verified that families play an influential role on adults in relation to the construction of their habits of attending cultural-artistic programs, and that these habits also influence their own families. We also concluded that the Interar-te Educational Program of MAC USP promotes teaching and learning concerning visual arts for people of different ages and promotes integration among the family members who visit the Museum.
BRUMANA, Mara (ORCID:0000-0002-8162-7133). "ORGANIZATION, COGNITION AND POLITICS IN MNCs. Longitudinal Evidence from an Italian Family-Owned Multinational Corporation". Doctoral thesis, Università degli studi di Bergamo, 2014. http://hdl.handle.net/10446/30741.
Testo completoDJOKO, KOUAM MOISE. "Correcteur d'echos longs pour les signaux de television. Application aux signaux de la famille mac/paquet". Rennes 1, 1994. http://www.theses.fr/1994REN10046.
Testo completoWang, Ying. "Expression de protéines protooncognes de la superfamille Myc (c-Myc, Max, Mad1, et Mxi1) et de la famille bcl-2 (Bcl-2, Bax) dans les chondrocytes du cartilage épiphysaire du rat". Paris 7, 1997. http://www.theses.fr/1997PA077084.
Testo completoMoreira, Vilson Alves. "Educação do campo e docência no contexto da agricultura familiar : o Programa Escola Ativa (PEA/MEC) no município de Salinas – MG". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/79130.
Testo completoThe issue of rural education and/or farm, though still lacking of research, has been increasing in the discussions and studies on Brazilian family farming over the recent decades. This is due to the recognition of the contribution of education to rural development. If, on the one hand, the State has the responsibility to recover this social aspect, on the other, social movements work together or in parallel with the actions of the State's struggle for their right to equitable quality education to which offers to other social classes. In this thematic approach, an analysis of the Active School (Escola Ativa) Program (EAP) provides the educational process of the Brazilian rural services. The EAP, based on the Colombian Escuela Nueva – Escuela Activa was officially implemented in Brazil by the Ministry of Education and Culture in 1997. This program has been considered as the first government system geared to the needs of the rural population with the children in the multi-seriated school system. In 2008, the program was expanded throughout Brazil and it was implemented in the city of Salinas, State of Minas Gerais in 2009. The Main Objective of this study is to analyze the implementation of the EAP/MEC/SALINAS - State of Minas Gerais, in terms of teacher training and pedagogical practice to check the socioeconomic, cultural and conditions of life of farmers in the region covered by EAP/SALINAS schools. A qualitative research approach has been carried out to understand how the dimensions of training and teaching take into account the local situation of the children of farmers, in order to improve their living conditions. In this context, the thesis defines the historical process of the development of public policies for rural education in parallel with the role of social movements in the claims and proposals for agricultural education based on their interests. It also shows the theoretical content of social analysis and education dedicated to the living conditions and education in rural areas. Discussions also on the EAP filing reflects the new time should be given to the teaching of the agricultural population and the possibility of the contribution of education to rural development. The characterization and analysis of the EAP in the city of Salinas has guided this framework of reflective and analytical content. The results show some progress, but also contesting the original hypothesis, i.e., consideration of the ineffectiveness of the variables and the socioeconomic and cultural conditions of life in the educational process of the EAP in the city of Salinas, State of Minas Gerais.
El tema de la educación rural y/o del campo, aunque todavía carece de investigaciones, ha ido en aumento en los debates y estudios sobre la agricultura familiar brasileña en las últimas décadas. Esto se debe al reconocimiento de la contribución de la educación al desarrollo rural. Si, por un lado, el Estado tiene la responsabilidad de recuperar este aspecto social, por el otro, los movimientos sociales funcionan en conjunto o en paralelo con las acciones de la lucha del Estado de su derecho a la educación de calidad equitativa a la que ofrece para otras clases. En este enfoque temático, un análisis del Programa Escuela Activa, (PEA) contiene el proceso educativo de los servicios rurales brasileños. El PEA, basado en la colombiana Escuela Nueva - Escuela Activa, se puso en práctica oficialmente en Brasil por el Ministerio de Educación y Cultura en 1997. Este programa ha sido considerado como el primer sistema de gobierno dirigido a las necesidades de la población rural con los niños en el sistema de escuelas multigrado. En 2008, el programa se extendió por todo Brasil y fue ejecutado en la ciudad de Salinas, Estado de Minas Gerais en 2009. El Objetivo Principal de este estudio es analizar la implementación del PEA/MEC/SALINAS - Estado de Minas Gerais, en términos de formación de profesores y la práctica pedagógica, para comprobar las condiciones socioeconómicas, culturales y de vida de los agricultores de la región cubierta por las escuelas PEA de Salinas. Un enfoque de investigación cualitativa se ha llevado a cabo para entender cómo las dimensiones de la formación y la enseñanza tienen en cuenta la situación local de los hijos de los agricultores, con el fin de mejorar sus condiciones de vida. En este contexto, la tesis define el proceso histórico del desarrollo de políticas públicas para la educación rural en paralelo con el papel de los movimientos sociales en las reivindicaciones y propuestas para una educación agrícola en función de sus intereses. También muestra los contenidos teóricos de análisis social y la educación dedicados a las condiciones de vida y la educación en las zonas rurales. Las discusiones interponiendo también en el PEA refleja el nuevo tiempo que se debe dar a la enseñanza de los ciudadanos agrícolas y las posibilidades de la contribución de la educación para el desarrollo rural. La caracterización y el análisis del PEA en el municipio de Salinas ha guiado este marco de contenido reflexivo y analítico. Los resultados obtenidos indican un cierto progreso, pero también la contestatión de la hipótesis original, es decir, la consideración de la ineficacia de las variables y las condiciones socioeconómicas y culturales de la vida en el proceso educativo del PEA en la ciudad de Salinas, Estado de Minas Gerais.
Mbatha, Mbalenhle. "A qualitative investigation of gendered perspectives on, maternity leave/family responsibility duties/social roles and access to career development, in the Johannesburg branch of a Multination Corporation (MNC): the case of company A, S.A. Johannesburg branch". Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/5657.
Testo completoBandino, Enrico. "Assessing the impact of ammonia content in VFA-rich streams on the PHA-storing MMC acclimatization and the PHA production stage". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
Cerca il testo completoCarmo, Inês Miguel Troles Duarte do. "Food waste valorization through the production of polyhydroxyalkanoates by mixed microbial cultures". Master's thesis, Faculdade de Ciências e Tecnologia, 2013. http://hdl.handle.net/10362/10454.
Testo completoPolyhydroxyalkanoates (PHAs) are polyesters of hydroxyl fatty acids, which are accumulated in microbial cells as carbon/energy reserves. PHAs are bio-based and biodegradable and display a wide range of thermoplastic properties, being a promising alternative to conventional plastics. Presently, industrial PHA production was primarily based on pure microbial cultures. Although this process has high PHA production efficiency, it presents high costs associated with the use of chemically-defined feedstocks, and to the need for sterility. An attractive feature of mixed microbial cultures (MMCs) PHAs production is the ability to use waste/surplus feedstocks. Many industrial wastes are seasonally produced making it necessary find the best method of utilization of this feedstock on PHA production process. Two different approaches might be taken account: (1) stock of industrial wastes during their production for their use throughout the year. However, the high fermentability of these agro-industrial wastes makes them susceptible to degradation during storage period; (2) the use of different feedstocks over the year according its availability. It is thus important to study MMC’s response to different feedstocks. The aim of this work is study how MMC PHA production process is affected by a feedstock shift, using cheese whey (CW) and sugar cane molasses (SCM) as model feedstocks. The use of waste based feedstock by MMCs requires a previous conversion of sugars to organic acids (OAs), which is achieved through anaerobic fermentation. In this study, a three-stage MMC PHA process was used, comprising: (1) anaerobic fermentation of surplus feedstocks to produce OAs in a membrane bioreactor (AnMBR); (2) PHA accumulating culture selection in a sequencing batch reactor (SBR) under feast and famine conditions using fermented feedstocks; and (3) PHA production using the selected cultures and the OAs produced in the earlier stages. Initially the effect of both feedstocks (CW and, SCM) in the acidogenic fermentation (stage 1) was assessed. Firstly, the AnMBR was operated under steady state with CW. When the feedstock was changed to SCM an adaption period of about 10 to 15 days was observed. When SCM was replaced by CW a faster adaptation response, approximately 7 days, was observed. The AnMBR reached similar OAs profiles in both phases when CW was fed (% g-COD HAA/g-COD OAs): 65% acetate, 10% propionate, 22% butyrate, 2% valerate, and 1% lactate. These results demonstrate that the system’s performance is reproducible. On the other hand, the anaerobic fermentation of a different feedstock, SCM, resulted in a different OAs profile (%g-COD HAA/g-COD OAs): 24% acetate, 38% propionate, 19% butyrate, and 19% valerate. In a second phase, different fermented feedstocks were used in the selection of PHA-storing organisms under a feast and famine regime in a SBR (stage 2). Initially the SBR was fed with a synthetic OAs solution; then fermented SCM (fSCM) and fermented CW (fCW) were subsequently fed as they were produced in the AnMBR. The adaption of the MMC to fSCM was faster than the adaptation to fCW. Whenever steady state was reached, PHA accumulation tests were performed using the enriched MMC fed with the corresponding feedstock (stage 3), namely synthetic OAs solution, fSCM, and fCW. Storage yields of 0.74, 0.49, and 0.73 C-mol PHA/ C-mol OAs were obtained with synthetic OAs solution, fermented molasses, and fermented CW, respectively. The culture reached a maximum PHA content of 60%, 56% and 65%, when feedstock fed were synthetic OAs solution, fSCM and fCW, respectively. A direct relation between the used feedstock and the polymers composition was observed, which was related with the different OAs profile. Even though, the shift of complex feedstock in three-stage MMC PHA process is still at a very early stage of development, this work illustrates the advantage of favoring the selection of cultures with the capacity to adapt its metabolism to different feedstocks. This will offer the possibility of using numerous substrates and improving strategies to optimize acidogenic fermentation, culture selection and polymer production.
Guerrini, Luca. "Process optimization for polyhydroxyalkanoate production by mixed microbial cultures within the B-PLAS project". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/24409/.
Testo completoChemelle, Julie-Anne. "Étude par modélisation moléculaire de l’effet allergène des antibiotiques de la famille des β- lactamines, tant sur le plan immédiat que retardé". Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10318/document.
Testo completoDrug hypersensitivity is an immune-mediated reaction to a drug. Our work was divided into four stages: 1 - We have classified β-lactam antibiotics based on their molecular fields, and obtained a dendrogram of 4 families, validated by clinical data. We also conducted a 3D-QSAR study to determine what parts of the drug are involved in the pathology and to predict the allergenicity of β- lactams. 2 - Under the assumption that β-lactam antibiotics are haptens, we studied their reactivity in comparison with lysine and serine. We then conducted "docking" experiments to define the interactions between the drug and human serum albumin. We conclude that lysine 190 and 212 are the most suitable sites for the covalent binding of the drugs. We validate this analysis by mixed QM / MM methods. Finally, thanks to our software SuMo, we have found other candidate proteins for haptenization. 3 - Regarding immediate hypersensitivity reactions, we modeled the IgE, the β-lactam and the haptenized protein. We considered several modes of recognition. Secondly, we analyzed the structural changes of the protein induced by the binding of the drug. 4 - Concerning delayed reactions, we considered different scenarios for the recognition of β-lactam by the TCR. We modeled complexes involving the TCR, the peptide haptenized by the β-lactam, a possible ion, and the MHC. We investigated them with molecular dynamics to study their relevance. On the other hand, we have identified many peptides derived from haptenization proteins and able to present the drug to the TCR through the MHC. The validity of the obtained results is or will be confirmed using experiments in vitro and in vivo
Gavlovsky, Pierre-Jean. "Polymorphisme et diversité des protéines MICA : caractérisation de nouvelles isoformes de MICA et rôle du variant MICA A5.1 en transplantation rénale". Nantes, 2015. https://archive.bu.univ-nantes.fr/pollux/show/show?id=7162c0ec-4c49-487d-a7d3-97e656a2d262.
Testo completoFunctionnal and morphological alterations of the enteric neuro-glio-epithelial unit (NGEU) have been consistently reported in digestive disorders such as irritable bowel syndrome or inflammatory bowel disease. There is mounting evidence that Parkinson's disease (PD) is not only a brain disease but also a gut disorder. Gastrointestinal involvement is a frequent and early event in the course of PD, and it may be critically involved in the early development of the disease. As in PD the enteric neurons accumulate a-synuclein, and thus are showing PD specific pathological features, we undertook the present PhD work to investigate whether the enteric glia in PD become reactive by assessing the expression and phosphorylation levels of GFAP protein in colonic biopsies. In parallel we investigated whether changes in the intestinal epithelial barrier (IEB) function and/or morphology occur in PD by measuring the para- and transcellular permeabilities in colonic biopsies and by assessing the expression and localization of the two tight junctions protein ZO-1 and occludin. As compared to control subjects, patients with PD had significant higher enteric GFAP expression levels whereas the phosphorylation at serine 13 was significantly lower. The para- and transcellular permeabilities were not different between PD patients and controls. The expression of occludin, but not ZO-1, was significantly lower in colonic samples from PD patients as compared to controls and the cellular distribution of both proteins was altered in PD patients. Our findings provides evidence that the NGEU is altered in PD via accumulation of a- synuclein in enteric neurons, enteric glial reaction and IEB morphological impairments. This PhD work further reinforce the potential role of the gastrointestinal tract in the initiation and/or the progression of the disease
Francoz, Edith. "Hybridation d'ARN in situ systématique de la famille multigénique des peroxydases de classe III durant le développement des graines d'Arabidopsis thaliana et étude fonctionnelle de AtPrx36 dans la dynamique pariétale des cellules sécrétrices de mucilage (MSC)". Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30159.
Testo completoPlant cell walls are complex structures, mainly composed of a large number of polysaccharides and proteins. The cell wall (CW) is a highly dynamic compartment which is remodeled by specific cell wall proteins (CWP). Among these CWP, the plant specific class III peroxidases (CIII Prxs) are a multigenic family of 73 members in Arabidopsis thaliana. CIII Prxs are involved in plant development but also in the interaction of the plant with its environment. However, only a few studies describing the exact function of individual members of this multigenic family have been published. This can be due to the weak in vitro substrate specificity of these enzymes and their possible functional redundancy, forcing to characterize their function in situ-in vivo and the use of multiple mutants. In this context, the first goal of my thesis was to establish the fine cellular spatio-temporal expression atlas of CIII Prxs throughout the seed development of Arabidopsis thaliana with an in situ hybridization (ISH) approach. This expression work (ISH) was partially permitted thanks to a recent published micro-transcriptomic study which allowed to compare both expression results (ISH vs micro-transcriptomic). This comparison showed that both techniques are complementary and it allowed to; (1) set a threshold for the ISH detection limit based on micro-transcriptomic expression values, and (2) to define specific spatio-temporal expression pattern that helps to select CIII Prx candidates for functional study. The second objective was to characterize the function of one of these CIII Prxs candidates (AtPRX36). We were able to determine the role of AtPRX36 during mucilage extrusion of imbibed seeds.Our results suggest that AtPRX36 is anchored within a globally methylesterified pectins CW micro-domain, putatively formed by the action of a pectin methylesterase inhibitor (PMEI6). This CW micro-domain is needed for the CW loosening action of AtPRX36 to permit CW polarized rupture during seed imbibition
Andeol, Yannick. "Contribution a l'etude des oncogenes cellulaires de la famille ras : caracterisation dans trois lignees tumorales humaines". Paris 6, 1987. http://www.theses.fr/1987PA066065.
Testo completoIlias, Wassila. "Etude des mécanismes d'expression des ligands de NKG2D lors des syndromes lymphoprolifératifs". Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ051.
Testo completoTumor cell’s uncontrolled proliferation induces an accumulation of genetic aberrations. In response to this genotoxic stress, most cells in transformation express NKG2D ligands (not expressed on resting cells), including MICA and MICB, which are non-conventional MHC class I molecules that could induce a cytotoxic T and NK response against the transformed cell. In chronic lymphoproliferative conditions, leukemogenic mechanisms rely in part on antigenic stimulations and/or activation of the B cell antigen receptor (BCR) pathways that induce cell proliferation. My thesis aims at studying : (i) the induction of MICA/B expression during lymphocyte proliferation and (ii) the mechanisms inducing this expression and their relationship with the DNA damage/repair pathways.I did generate BCR activation conditions to obtain B cells proliferation from healthy control individuals and from patients suffreing from chronic lymphocytic leukemia (CLL), the most common leukemia in adults. MICA and MICB expression was assessed by quantitative PCR, flow cytometry, Western blotting and ELISA after activation of B-cell proliferation. The different signaling pathways downstream BCR were analyzed, as were the kinetics of the DNA damage during this process. The results show that MICA/B aren’t expressed on cell surface of B cells from healthy control individuals or CLL patients before activation. Lymphoproliferative stimulation however up-regulates both MICA mRNA and surface protein in these same cells. This expression was induced by several BCR and by JAK/STAT pathways and seems to be indpendant of DNA damage. In conclusion, antigen receptor activation that induces lymphocyte proliferation also induces MICA expression (but not MICB) on B cells surface from healthy control individuals and this expression capacity is conserved in B cells from patients suffering from CLL. These results suggest that MICA may play a crucial role in the early stages of anti-proliferative immunity, which opens the avenue for therapeutic interventions
Jílková, Tereza. "Neuchopitelné přední hledisko: Představy o rodině a nejlepším zájmu dítěte v rámci svěřování dětí do náhradní rodinné péče/výchovy". Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-368881.
Testo completoLapouge, Marjorie. "Implication de la signalisation de la tyrosine kinase Yes dans la carcinogenèse hépatique". Thesis, 2020. http://hdl.handle.net/1866/25271.
Testo completoHepatocellular carcinoma (HCC) is the first lethal neoplasia of the liver, representing 80 to 90% of cases. Currently, for most patients the therapeutic option only provides modest efficiencies. The high etiological variety and heterogeneity of the tumors as well as the absence of known key oncogenic mediator in the development of this pathology is mainly responsible for the lack of therapeutic option. Based on a genetic screen of the human kinome, we identified the tyrosine kinase Yes as a major player in the proliferation of HCC cells. Yes belongs to the family of Src kinases which control many cellular processes including proliferation, motility and survival. The over-expression or abnormal activation of Yes is detected in many cancers and is often associated with poor prognosis. We have demonstrated in vitro and in vivo the pro-proliferative activity of Yes as well as its oncogenic potential. In particular, in a mouse model of hepatic carcinogenesis induced by diethylnitrosamine, the genetic depletion of Yes completely abolishes the formation of tumors. Thanks to the transcriptional profiles obtained in several cellular models of CHC, we discovered that the activity of Yes is associated with an increase in the gene signatures of the transcriptional regulators YAP and TAZ as well as of the transcriptional factor c-Myc. These observations led to the identification of YAP, TAZ and c-Myc as new substrates for the tyrosine kinase Yes. We have shown that the phosphorylation of YAP and TAZ by Yes mediates their recruitment into the nucleus associated with an increase in their transcriptional activity. We have also confirmed the importance of YAP and TAZ in the proliferative properties of Yes in various mouse models of hepatocarcinogenesis. Interestingly, we observed that nearly 50% of human CHCs exhibit an abnormal activation of Src kinases that correlates with phosphorylation and activation of YAP. Moreover, in vitro and in vivo experiments revealed that Yes stabilizes c-Myc. Indeed, the transgenic expression of constitutively active Yes into hepatocytes leads to the accumulation of c-Myc protein at early stages of tumor development and to the induction of several of its target genes at later stages. In addition to their synergistic action, this study suggests that Yes is involved in the oncogenic properties of c-Myc. Finally, we discovered that Yes kinase plays a role in the progression of fatty liver diseases. Indeed, the progression of the pathology is abolished following the depletion of Yes or the pharmacological inhibition of Src kinases. In addition, the survival of Yes-active tumor cells is associated with the induction of PD-L1/2 immune checkpoints that protect cells from immune elimination. In conclusion, we have discovered and characterized three new key effectors of the oncogenic tyrosine kinase Yes in HCC. Interestingly, the gene signature induced by Yes can predict the survival of patients with HCC. These data provide strong evidence for targeting the tyrosine kinase Yes in HCC.
Hovorka, Jan. "Rodina v moderním americkém dramatu". Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-298950.
Testo completoDvořáček, Pavel. "Strategie harmonizace pracovního a rodinného života vysokoškolsky vzdělaných žen v počátcích jejich kariéry". Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-350696.
Testo completoCardoso, Berta Sofia Matos da Silva. "A monitorização com base no currículo para identificar alunos em risco de apresentarem dificuldades de aprendizagem específicas e para conhecer as suas experiências de leitura em contextos familiares e comunitários". Master's thesis, 2014. http://hdl.handle.net/1822/31353.
Testo completoEste estudo teve como finalidade conhecer a perceção dos alunos sobre as suas experiências de leitura em contextos familiares e comunitários, no âmbito da primeira fase do modelo de resposta à intervenção. Estudamos a população de 1432 alunos do 3.º ano de escolaridade de 12 Agrupamentos de Escolas do Concelho de Braga, num total de 85 turmas. Para este estudo foi utilizado um questionário denominado “Ler: A voz dos alunos”. Para a seleção de alunos em risco e alunos não em risco foram utilizados os dados recolhidos através uma prova de Monitorização com Base no Currículo (MBC) - compreensão (MBC-MAZE). Os resultados permitiram concluir que: a) as experiências de leitura em contextos familiares e comunitários não são diferentes entre rapazes ou raparigas, no que respeita ao gosto pela leitura, ao conhecimento das letras do alfabeto aquando da entrada para a escola do 1.º Ciclo do Ensino Básico e à consciência sobre a sua prestação na leitura; b) as experiências de leitura em contextos familiares e comunitários são diferentes entre rapazes ou raparigas, no que respeita à visita a bibiotecas ou livrarias, à realização de jogos de rimas, ao diálogo com um adulto sobre palavras desconhecidas, ao hábito de ler sozinho, ao hábito de ler acompanhado por um adulto, à correção, por parte de um adulto, das palavras que o aluno não lê bem, ao diálogo com um adulto sobre o que leram e ao hábito de ver adultos a ler; c) o gosto pela leitura é diferente nos alunos em risco e nos alunos não em risco de apresentaram dificuldades de aprendizagem específica na leitura; d) o número de vezes que visitam bibliotecas e livrarias é diferente nos alunos em risco e nos alunos não em risco; e) o hábito de fazer jogos de rimas é diferente nos alunos em risco e nos alunos não em risco; f) o conhecimento das letras do alfabeto aquando da entrada na escola do 1.º ciclo do Ensino Básico é diferente nos alunos em risco e nos alunos não em risco; g) o hábito de ler sozinho é diferente nos alunos em risco e nos alunos não em risco; h) o hábito de ler acompanhado por um adulto é diferente nos alunos em risco e nos alunos não em risco; i) a correção, por parte de um adulto, das palavras que o aluno não lê bem apresenta diferenças entre os alunos em risco e os alunos não em risco; j) o hábito de ver adultos a ler apresenta diferenças entre os alunos em risco e os alunos não em risco; k) a consciência sobre a sua prestação na leitura é diferente nos alunos em risco e nos alunos não em risco; l) o valor do Alfa de Cronbach para o inquérito foi de 0,585.
This study aimed to understand the students' perceptions about their reading experiences in family and community contexts, within the first phase of the response to intervention model. It was used a sample of 1432 students enrolled in the 3rd grade of 12 school clusters in the Municipy of Braga, in a total of 85 classes. For this study it was used a questionnaire called “ Reading: the voice of the students”. Data was collected through a curriculum-based-measurement probe (CBMMAZE) for the selection of at risk students and students not at risk. The results showed that: a) reading experiences in family and community contexts are not different between boys and girls, as regards to the pleasure of reading, to the knowledge of the alphabet letters on entry to 1st grade and the awareness on their performance in reading; b) reading experiences in family and community contexts are are different between boys and girls, as regards to the visits to libraries or bookstores, conducting rhyming games, to the dialogue with an adult about unknown words, to the habit of reading alone, to the habit of reading with an adult, to correction of the words that the student does not read well by an adult, to the dialogue with an adult about what they read and to the habit of seeing adults reading; c) the pleasure of reading is different for students at risk and students not at risk for specific learning difficulties in reading; d) the number of times they visit libraries and bookstores is different for students at risk and not at risk students; e) the habit of conducting rhyming games is different for students at risk and not at risk students; f) the knowledge of alphabet letters when entry to 1st grade is different for students at risk and not at risk students; g) the habit of reading alone is different for students at risk and not at risk students; h) the habit of reading with an adult is different for students at risk and not at risk students; i) the correction of the words that student doesn’t read well, by an adult, is different between at risk students and students not at risk; j) the habit of seeing adults reading is different at risk students and students not at risk; k) the awareness about his performance in reading is different in at risk students and students not at risk; l) the value of Cronbach's alpha for the survey was 0,585.