Tesi: "Literature and transplantation of organs"

1

Pummer-Verté, Lila. "Organ donation and transplantation /". Online version of thesis, 1995. http://hdl.handle.net/1850/12252.

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2

Ferraz, Viriato Marco Gomes. ""Organs Transplantation - how to improve the process?" Master's thesis, Faculdade de Medicina da Universidade do Porto, 2010. http://hdl.handle.net/10216/55371.

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3

Ferraz, Viriato Marco Gomes. ""Organs Transplantation - how to improve the process?" Dissertação, Faculdade de Medicina da Universidade do Porto, 2010. http://hdl.handle.net/10216/55371.

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4

Wotherspoon, John Scott. "Studies in transplantation tolerance". Thesis, The University of Sydney, 1990. https://hdl.handle.net/2123/26352.

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Abstract (sommario):

The most fundamental function of the immune system is discrimination between the molecules that constitute "self" and those of foreign organisms, tissues or substances which the organism encounters during life. This immunological discrimination between self and non-self is vital to the maintenance of the biological integrity of the organism and is evident at the lowest phylogenetic levels (Hildemann et al., 1977). Encounters with molecules which are recognised as non-self trigger the immune system to initiate effector mechanisms by which the foreign molecules are eliminated. The diverse range of self molecules, however, does not apparently induce a similar response. The lack of responsiveness to self molecules, so called self-tolerance, is thought to be acquired during the development of the lymphoid system. As yet, the actual process by which the immune system distinguishes self and non-self molecules is not fully understood and remains a central issue of cellular immunology.

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5

Van, den Berg Leon. "Organ and tissue donation and transplantation a perspective of South African Baptists from the Baptist Northern Association and its implications for preaching /". Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-10022007-164428/.

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6

Motallebzadeh, Reza. "Tertiary lymphoid organogenesis in solid organ transplantation". Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608121.

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7

Zheng, Ling 1958. "Airway inflammation and remodelling post human lung transplantation". Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/8099.

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8

Fisher, Karen Joan. "Allocating scarce resources an ethical case study of organ transplantation /". Theological Research Exchange Network (TREN), 1997. http://www.tren.com.

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9

Gryf-Lowczowski, Jan Victor Dobek. "Pharmacology and morphology of cold stored human and rabbit arteries in an evaluation of preservation solutions". Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309129.

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10

Chudik, John D. "Human fetal tissue transplantation an Orthodox Christian ethical evaluation /". Theological Research Exchange Network (TREN), 1994. http://www.tren.com.

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11

Pawlowski, Kai. "Die strafrechtliche Bewertung der Organtransplantation /". Bochum : [s.n.], 2007. http://swbplus.bsz-bw.de/bsz267327285inh.pdf.

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12

Plata-Muñoz, Juan José. "Clinical, biochemical and molecular markers of injury before transplantation". Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572681.

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Abstract (sommario):

The use of organs from donors after circulatory death (DCD) has been recommended as one strategy to enlarge the donor pool and raise the transplant rate. However, DCD allografts had higher incidence of early post-transplant dysfunction. The general aim of this research project was to develop clinical and experimental strategies to reduce the incidence of early post-transplant dysfunction of kidney and liver allografts from DCD. First the ability of a clinical scoring system based on donor data for identifying DCD kidneys with high-risk of post-transplant dysfunction was evaluated using the Oxford and the UK National DCD kidney transplant cohorts. This works suggest that stratification of DCD kidneys before transplantation might allow early identification of kidneys in which lower graft function and survival could be expected if any additional therapeutic intervention is implemented. Second, as it has been suggested that hypothermic machine perfusion (HMP) may protect DCD kidneys from additional preservation injury and improve their outcome after transplantation, this work explored the benefit of HMP as preservation technique fo DCD kidneys in Oxford and discusses the potential of this technique for reducing the incidence of post-transplant dysfunction in DCD kidneys. The Oxford. Liver Group has provided evidence of the benefit of preservation with normothermic machine perfusion (NMP) on post-transplant function and survival of DCD liver allografts. In this work, the molecular mechanisms associated with this benefit were characterized using micro array technology. This analysis suggests that the beneficial effect ofNMP may be associated with the induction of the ischaemic preconditioning phenomenon and highlights a group of genes with potential for gene therapy. Finally, this works provides the "proof-of-concept" that the use of a non-mammalian viral vector for gene transfer of kidneys and livers during conventional cold preservation is feasible and is not associated with additional tissue injury.

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13

Wong, Mei-yi, e 王美兒. "Improving engraftment potential of hMSCs after encapsulation in collagen microsphere: an in vitro and in vivostudy". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47753080.

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Stem cell-based therapies are promising in regenerative medicine. However, the success of cell therapy is greatly limited by the low engraftment rate to the target tissues. The present study demonstrated that human mesenchymal stem cells (hMSCs) were subjected to a self selection process via microencapsulation in collagen barrier when they were induced to migrate out from this barrier. While retaining the immuophenotype and self renewal capacity, the selected hMSCs showed a significantly better in vitro migratory response of than those cultured in traditional monolayer. The migratory response could be controlled by varying the fabrication parameters of the collagen barrier, including initial collagen concentration and cells seeding density. Affinity to adhere on endothelial cells layer is another engraftment related property. Significant difference was observed between these selected hMSCs and hMSCs in monolayer culture. In order to investigate the engraftment potential of the selected hMSCs, an animal model was performed. The selected hMSCs were transplanted intravenously into NOD/SCID mice under partial hepatectomy. Presence of human cells in the residual liver was determined by the presence of human HLA-ABC using flow cytometry after 48 hours, 1 week and 1 month. Engraftment of the selected hMSCs was significantly higher than that of monolayer cultured hMSCs in time point of 1 month. It demonstrated that the selected hMSCs favor the engraftment to the injured liver. Further investigation is required to determine the fate of the engrafted hMSCs in order to truly confirm their therapeutic potential. The current work demonstrated that collagen-hMSCs microsphere could act as a barrier to select hMSCs with enhanced in vitro migratory response and in vivo engraftment properties. These findings may contribute towards the development of better stem cell therapies.
published_or_final_version
Mechanical Engineering
Master
Master of Philosophy

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14

Nagel, Markus. "Organtransplantation und Internationales Privatrecht". Berlin ; Heidelberg : Springer, 2009. http://deposit.d-nb.de/cgi-bin/dokserv?id=3182142&prov=M&dok%5Fvar=1&dok%5Fext=htm.

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15

Tsang, K. "Prioritization preferences for corneal transplantation allocation in Hong Kong". Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31972226.

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16

Shubane, Nancy. "Black critical care nurses' perceptions of organ donation and organ transplantation". Pretoria : [s.n.], 2009. http://upetd.up.ac.za/thesis/available/etd-10262009-185326/.

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17

Hamer, Clare Louise. "Ethical issues relating to the 'donation' of human and animal organs for transplantation". Thesis, University of Leeds, 2003. http://etheses.whiterose.ac.uk/237/.

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This thesis is an investigation into several proposed ways of increasing the supply of organs for transplantation purposes. It starts from a consideration of two sorts of donors which are already in use: humans declared dead according to brain-based criteria and nonhuman animals. In the first chapter I attempt to provide a theoretical underpinning for the brainstem criterion of brain death. I also criticise certain rival theories. In the second chapter I consider what constraints govern what we may do to the newly dead body - the fact that someone is dead does not mean we may treat their corpse as we please. I consider Professor John Harris' strong `opting out' policy, and argue against it. I briefly discuss other alternatives to the UK's present `opting in' system - `presumed consent' and `required request'. And I consider the problems generated by the proposed use as donors of another category of human cadaver - people declared dead according to cardiorespiratory criteria. The third chapter is an investigation into xenotransplantation - the use of organs from nonhuman animals. I argue that using animals `just because' they are animals is ethically indefensible. Instead I attempt to justify the killing of (some) animals as organ donors on the grounds that their interest in continued life is weaker than that of a human. But this has some counterintuitive implications concerning arational members of our species. In the final chapter I discuss the possible use of the `worst off' category of arational humans - the permanently and irreversibly unconscious. I argue that we have moral obligations to these people which do not stem only from a consideration of their interest in life. However, I think that we may use such people as donors under specialised conditions: if we are as certain as we can be that they are irreversibly unconscious, if their family (and ideally the donor too) have requested it, and so long as it can be done without distress to the public. Under no other circumstances do I think humans ought to be killed for organs.

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18

Dare, Anna Jane. "Targeting mitochondria during ischaemia-reperfusion injury in organ transplantation". Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708069.

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19

Poliachik, Sandra Louise. "Transplant organ preservation cooler". Thesis, Virginia Tech, 1991. http://hdl.handle.net/10919/41591.

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A method for preserving transplant organs for extended periods of time has been developed in the transplant organ preservation cooler. The preservation cooler enhances organ viability by maintaining a temperature controlled organ bath and pumping perfusate through the transplant organ. The emphasis on the transplant organ preservation cooler is to provide a simple and portable system which will be powered by boiled off oxygen from a liquid oxygen source. The design of the preservation cooler pump and temperature control system are presented. Results of tests proving the successful operation of the preservation cooler prototype are also presented.
Master of Science

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20

Cabaniss, Thomas Ervin. "The pastor's ministry to people facing organ transplantation". Online full text .pdf document, available to Fuller patrons only, 2001. http://www.tren.com.

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21

Weston, Lyanne. "An investigation of relationships between cytokine-secreting T lymphocytes and transplantation outcome". Thesis, The University of Sydney, 2002. https://hdl.handle.net/2123/27850.

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Abstract (sommario):

A major limitation to the success of transplantation is the immune interaction of the recipient and the graft tissue. When considering solid organ transplantation the major obstacle is overcoming rejection by the recipient of the foreign graft. For bone marrow transplantation it is the response of the immunologically viable donor cells to the immunocompromised recipient resulting in the development of Graft—versus-Host Disease. T cells play a crucial role in the immune response in transplantation by dictating allograft rejection and acceptance. Recognition of (or by) transplanted cells as self or foreign is determined by the highly polymorphic genes of the MHC locus. Although rejection may be prevented or treated by immunosuppressive drug therapy, minimising the immunogenicity of the graft by limiting MHC differences is preferable. When considering solid organ transplantation however, matching for MHC parity is rarely practicable. In Bone marrow transplantation parity at MHC is highly recommended. Matching by molecular and cellular techniques, use of siblings, and depletion of T cells from the inoculum are all techniques currently used to minimise alloreactivity. Despite matching at the MHC there are donor-recipient pairs for whom success eludes after bone marrow transplantation. Given the current capability to identify and characterise the MHC alleles of all potential bone marrow transplant pairs using molecular typing, it is thought that this reaction is directed against minor histocompatibility antigens.

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22

Tziampazis, Evangelos. "Engineering functional, insulin-secreting cell systems : effect of entrapment on cellular environment and secretory response". Thesis, Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/10026.

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23

Bedaiwy, Mohamed Ali. "Ovarian tissue cryopreservation and transplantation : approaches and techniques /". Cleveland, Ohio : Cleveland Clinic, 2007. http://www.loc.gov/catdir/toc/ecip082/2007042633.html.

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24

Waring, Duff William Ramus. "Medical benefit and the human lottery an egalitarian approach to patient selection /". Dordrecht ; Norwell, Mass. : Springer, 2004. http://site.ebrary.com/id/10221758.

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25

Staatz, Christine Elizabeth. "Population pharmacokinetics of tacrolimus with pharmacodynamic exploration in different organ transplant groups /". St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16521.pdf.

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26

Greenwood, Gay. "The spaces within : a Foucaudian analysis of organ donation discourses /". Title page, table of contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phg81652.pdf.

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27

Wong, Hoi-ling, e 王凱玲. "Migration and other characteristics of collagen microencapsulated hMSCs: a comparison with hMSCs intraditional 2D culture". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B4150902X.

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28

Summers, Dominic Mark. "Maximising the potential for kidney donation in the UK : the role of donation after circulatory-death". Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.645969.

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29

Wong, Hoi-ling. "Migration and other characteristics of collagen microencapsulated hMSCs a comparison with hMSCs in traditional 2D culture /". Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B4150902X.

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30

Waln, Donna L. "The ethics of fetal tissue research and transplant". Theological Research Exchange Network (TREN), 1998. http://www.tren.com.

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31

Nikkhah, Guido. "Microtransplantation of nigral dopamine neurons in a rat model of Parkinson's disease studies on functional recovery and structural repair in adult and neonatal rats with lesions of the mesotelencephalic dopamine system /". Lund : Dept. of Medical Cell Research, Lund University, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39693821.html.

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32

Li, Xianliang, e 李先亮. "Insulin in UW solution exacerbates the ischemia/reperfusion injury in rat liver transplantation". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B27785257.

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33

Akhtar, Mohammed Zeeshan. "Improving the outcomes of kidney transplantation from deceased organ donors". Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:cd7c49f5-e5ce-415b-bdcb-7b59197bc1d0.

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Abstract (sommario):

This thesis sought to improve our understanding of how kidneys become injured as a consequence of organ donation, with the aim of improving the outcomes of transplantation. Every year, hundreds of patients on the waiting list die whilst awaiting a kidney transplant. With an ever-increasing demand for suitable organs, supply cannot keep up with the pressures on the transplant waiting list. As a consequence the transplant community are forced to use organs that previously would not have been considered suitable for transplant, including from older donors with additional comorbidities. This thesis aimed to develop an understanding as to how the kidney becomes injured during the donation process, identifying which key cellular homeostatic processes are disturbed as a consequence of donation. The thesis outlines the experimental development of rodent models of organ donation replicating the donation process for donation after brain death (DBD) and donation after circulatory death (DCD) donors and also the development of a kidney ischaemia reperfusion injury (IRI) model. Proteomics was subsequently used to identifying global protein alterations in the kidney as a consequence of brain death and ischemia reperfusion injury using bioinformatics tools to identify involvement of cellular pathways. The results indicated alterations in mitochondrial function and metabolic homeostasis occurring following brain death. Alterations in cellular metabolism and mitochondrial function were then confirmed using metabolomics and mitochondrial functional assays. I subsequently evaluated how alterations in cellular hypoxia and the hypoxia inducible factor system is altered in the brain dead organ donor kidney and aimed to target this system as a means of conditioning the brain dead organ donor to prevent mitochondrial and metabolic mediated injury to kidney cells following brain death. This involved exploring the role of prolyl hydroxylase inhibitors, including dimethyloxalylglycine, on mitochondrial function and whether this could be a therapeutic target in organ donation. This thesis provides important insights into the mechanism of injury of kidneys following brain death, providing evidence that even before procurement and preservation in the DBD donor alterations in mitochondrial function and metabolic homeostasis occur. I provide preliminary data on the use of prolyl hydroxylase inhibitors in altering mitochondrial function. I also outline my involvement in other ongoing projects in organ donation and machine perfusion that also aim to improve the outcomes of deceased donor kidney and liver transplantation.

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34

McGregor, Lesley M. "An investigation into the functional and psychosocial impact of living organ donation". Thesis, University of Stirling, 2010. http://hdl.handle.net/1893/2338.

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General Abstract Objective: In April 2006, the Scottish Liver Transplant Unit (SLTU) became the first NHS transplant unit in the UK to offer the option of Living Donor Liver Transplantation (LDLT). This represented a unique opportunity to evaluate the functional and psychosocial impact of LDLT upon healthy donors and their recipients. Subsequent aims were to investigate the challenge of introducing LDLT in Scotland and to establish the perceived deterrents and attractions of the procedure. An additional aim was to evaluate the impact of Living Donor Kidney Transplantation (LDKT) upon donors and recipients. Design: A series of cross sectional and longitudinal studies were designed for the purpose of this thesis (3 quantitative, 2 qualitative, and 1 mixed methods). Method: Self report questionnaires were used in each of the quantitative studies, with the addition of neuropsychological computerized tests in two studies. Semi-structured interviews were employed in the qualitative studies. Main Findings: •Prior to its introduction general support for the option of LDLT was found, although it was highlighted that the risk involved was not well understood by the general public. •Since becoming available LDLT has not been a readily acceptable treatment option from the perspective of patients due to the perceived risk for the donor, but it may be considered as a “last option”. Family members were motivated to save their loved one’s life but the personal implications of donating resulted in reconsideration of LDLT. • Staff at the SLTU perceived a lack of family commitment in relation to LDLT, which is explained as a cultural factor contributing to the slow uptake of LDLT. In Scotland, a donation from a younger to an older generation is not easily accepted. This, in addition to patients’ optimism that a deceased donation will arrive, and the poor health of potential donors, is thought to have affected the uptake of LDLT. As has the unit’s conservative approach to the promotion of LDLT. This approach is the result of a perceived reduction in the need for LDLT and a preference to avoid the risk to a healthy donor and conduct transplants with deceased donations. • In over 3 years, only one couple completed LDLT. The recipient showed functional and psychosocial improvement from pre to post procedure, whilst the donor showed slight deterioration in aspects of quality of life 6 weeks post donation, which did not always completely return to a baseline level by 6 months. The donor made sacrifices to provide her husband with a fresh start to life and unmet expectations were found to effect quality of life. •Willingness to become a liver donor is not thought to be influenced by the frame of the information provided. •Like the LDLT donor, LDKT donors experience some functional and psychosocial deterioration at 6 weeks post donation, but donors largely recover by 6 months post donation. However, the anticipated benefit to recipients was not evident and may not be quantifiable until after 6 months post operation. Conclusion: This thesis has added to current knowledge on living organ donation and specifically represents the first psychological evaluation of a UK LDLT programme. The slow uptake of LDLT was unexpected and has resulted in informative, novel research.

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Moalimishak, Mohamed Rashad. "[The] ethical evaluation of brain dead persons and organ transplantation in contemporary Muslim ethics". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=105427.

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Abstract (sommario):

This dissertation is primarily about the ethical evaluation ofbrain death, brain-dead persons and organ transplantation in contemporary Muslim ethics.
Cette tQese est premierement au sujet de l'évaluation éthique de la mort cérébrale et les personnes dans un coma dépassé aux éthiques Musulmanes contemporaines.

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36

Packthongsuk, Kreeson. "Detection of porcine umbilical cord matrix stem cells in the intestine and other organs after oral and intraperitoneal administration to allogeneic recipients". Diss., Kansas State University, 2013. http://hdl.handle.net/2097/16753.

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Doctor of Philosophy
Department of Animal Sciences and Industry
Duane Davis
Umbilical cords matrix stem cells (UCs) have been characterized most thoroughly in humans (HUCs) and are considered to have great promise for regenerative medicine and cell-based therapy. Although UCs were first identified in pigs the description of porcine UCs (PUCs) is limited. Here we reported some standard mesenchymal stem cell characteristics for PUCs. Development of knowledge about PUCs is useful because the pig is a valuable biomedical model for humans and the species is an important human food source. PUCs were isolated from Wharton’s jelly using an explant technique. They attached on the plastic and showed fibroblast-like morphology. Immunophenotype analysis showed they are positive for CD44, CD90 and CD105 and negative for CD31, CD45 and SLA-DR. Under specific in vitro conditions, PUCs were differentiated to adipocytes, chondrocytes and osteocytes. The growth curve of PUCs exhibited a lag phase, log phase and doubling time of 24, 60 and 13.8 hour respectively. Engraftment potential of allogeneic PUCs administered orally and intraperitoneally (IP) was evaluated. Newborn, 1-day, 1-week, 2-week and 3-week old pigs were administered a dose of fluorescently labeled PUCs (1.1x107 cells/kg body weight) and their tissue incorporation were evaluated using confocal microscopy with confirmation by PCR to detect SRY gene, the Y-chromosome gene of male PUCs in female recipients. One week after PUCs administration, they were found mostly in the gastrointestinal tract and abdominal organs after either oral or intraperitoneal transplantation. The intestinal mucosa layer around the base of villi and intestinal crypts was the main location. PUCs were also detected in thoracic organs, muscle and bone marrow. Additionally, PKH26-labeled fibroblasts labeled were detected in recipient intestine 1 week after IP injection. Donor cells were not found in blood at one week post transplantation. When recipients were sacrificed at 6 h after IP injection PKH26-labeled PUCs were found mostly in omentum and diaphragm by PCR. It is likely these are the primary sites for donor cells in the peritoneal cavity to enter the circulation. Fluorescent in situ hybridization (FISH), using an SRY probe and PCR, demonstrated the PUCs isolated from recipient intestines by enzymatic digestion. Therefore, transplanted PUCs were recovered from the intestinal mucosa and were viable and able to proliferate in vitro.

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37

Wong, Dorothy Wai Yi. "Shakespeare in Hong Kong : transplantation and transposition". HKBU Institutional Repository, 1995. http://repository.hkbu.edu.hk/etd_ra/33.

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38

Tsang, K., e 曾光. "Prioritization preferences for corneal transplantation allocation in Hong Kong". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31972226.

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39

Dansirikul, Chantaratsamon. "Pharmacokinetic studies with sirolimus and tacrolimus /". [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18266.pdf.

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40

楊振帆 e Zhenfan Yang. "Recombinant adeno-associated virus vector as a novel vehicle organ transplantation and long-term allograft survival induced by rAAV-hCTLA4Ig gene transfer combined with low-dose FK506". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31243861.

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41

Higginbotham, Bradley Y. Beard T. Randolph. "An examination of the impact of the Organ Donation Breakthrough Collaborative on kidney transplant activity". Auburn, Ala, 2009. http://hdl.handle.net/10415/1738.

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42

Kozak, Allyson Jill. "The balance of nitric oxide and peroxynitrite in the heart during organ preservation". View abstract, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3295438.

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43

Yang, Zhenfan. "Recombinant adeno-associated virus vector as a novel vehicle organ transplantation and long-term allograft survival induced by rAAV-hCTLA4Ig gene transfer combined with low-dose FK506 /". Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25085530.

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44

Lexis, Louise A. "Cyclosporine A induced alterations to endothelial function and erythrocyte and plasma redox balande, and the benefits of antioxidant supplementation /". [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18605.pdf.

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45

Мокрозуб, О. С. "Протидія незаконній трансплантації органів як гарантія забезпечення права на життя". Thesis, Українська академія банківської справи Національного банку України, 2009. http://essuir.sumdu.edu.ua/handle/123456789/61127.

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46

Dugan, Aisling Siobhan. "The interactions between BK virus and host cell receptors". View abstract/electronic edition; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318311.

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47

Hing, Alfred Victor Chang Cardiac Research Institute Faculty of Medicine UNSW. "Optimising the quality of donor organs for transplantation: studies of hormone resuscitation of the brain-dead multi-organ donor and the development of a long-term preservation strategy to optimise function of the transplanted heart in a porcine model". Awarded by:University of New South Wales. Victor Chang Cardiac Research Institute, 2009. http://handle.unsw.edu.au/1959.4/44792.

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Brain death has adverse effects on the organ donor, increasing organ dysfunction and affecting transplantation outcomes. It can also render organs unsuitable for transplantation. Another determinant of organ quality is ischaemia-reperfusion injury, which limits ischaemic storage time for hearts to six hours. The aim of this thesis was to investigate the effectiveness of hormone resuscitation (HR) of the donor to ameliorate the effects of brain death. Another aim was to develop a donor management and organ preservation strategy to ameliorate the effects of ischaemia-reperfusion injury on the heart, thereby extending ischaemic preservation times. A porcine model of the brain-dead multi-organ donor with orthotopic cardiac transplantation was utilised. Donor HR was shown to improve cardiac contractility and haemodynamics, thereby reducing inotrope requirements. A follow-up study investigating the effects of three different donor management protocols demonstrated that donor haemodynamics, renal arterial flow and creatinine clearance were superior in HR animals compared with animals treated with noradrenaline or intravenous fluid alone. Noradrenaline was associated with a significant deterioration in pulmonary function (PaO2 and alveolar-arterial oxygen gradient) and a decline in donor pH. HR was not associated with any detrimental effects on the lungs, liver or pancreas compared with the other two groups. Preservation strategies incorporating glyceryl trinitrate (GTN) and cariporide, a Na+-H+ exchange inhibitor, were investigated to safely extend cardiac ischaemic preservation times. Pre-treatment with intravenous cariporide prior to heart explantation (donor) and reperfusion of the transplanted heart (recipient) was shown to effectively extend ischaemic time to 14 hours, evidenced by weaning off cardiopulmonary bypass. GTN and cariporide-supplemented Celsior, used as a cardioplegic/storage solution, was also effective in extending preservation time to 14 hours, with superior cardiac contractility compared with cariporide pre-treated hearts. Both treatments also ameliorated reperfusion injury, stabilising haemodynamics for up to three hours post-bypass. This thesis has demonstrated the effectiveness of HR to ameliorate the negative effects of donor brain death. It also provides evidence that combined GTN and cariporide-supplemented Celsior improves long-term preservation of the donor heart. These strategies offer the potential to increase the proportion of transplantable organs, to improve donor organ quality, and thereby improve transplantation outcomes.

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48

Chan, Chun-wai, e 陳春慧. "In-vitro study of the cryopreserved intervertebral disc". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290380.

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49

Bester, Dreyer. "A study of the effects of warm ischaemic times on harvested homografts". Thesis, Bloemfontein : Central University of Technology, Free State, 2009. http://hdl.handle.net/11462/48.

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50

Crouch, Robert Alan. "The child as tissue and organ donor". Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23714.

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This thesis attempts to answer the following question: Is it ever morally permissible to use a minor child as a tissue or organ donor for the benefit of a family member? Those sceptical of using minors as tissue or organ donors for the benefit of a sick family member will highlight two points: the donor will be subject to risks that are not counterbalanced by possible medical benefits, and the minor cannot consent to the procedure herself.
This thesis will present a review of the medical risks associated with bone marrow and kidney donations, as well as a review of the common law dealing with donations by minors and incompetent persons. The final chapter then makes a case for the permissibility of minor donation based on the interests of the family.

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Tesi sul tema "Literature and transplantation of organs"

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