Tesi sul tema "Ligand imine"
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Holub, Jan. "Generation of coordination architectures from dynamic covalent ligand libraries". Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF060/document.
Testo completoDynamic Combinatorial Chemistry of imine-based dynamic covalent bonds (-C=N-), under the governance of coordination chemistry, can lead to different metallosupramolecular architectures and responsive functional systems. In this work these two aspects have been approached. Grids and helicates architectures based on aldehydes and amines/hydrazines backbones have been synthesised, in order to probe their behaviour in a dynamic network environment, using both octahedral and tetrahedral coordinating metal cations. Dynamic systems can be also represented by dynamic networks that define agonistic and antagonistic relationships between different constituents linked through component exchange. These networks can be switched through amplification of the best fittest constituent(s) in a dynamic set, allowing to access higher level functions such as training, learning, and decision making for adaptive chemical systems. A novel multi responsive system, able to be trained for information storage, has been studied, exhibiting a stable distribution even after removal of the metal stimuli, making this system able to perform information processing operations: training, storage, recall, and erase
Prema, Dipesh. "Different coordination modes of bis(imine-ridine) and bis(quinaldine) ligands". Diss., Manhattan, Kan. : Kansas State University, 2007. http://hdl.handle.net/2097/267.
Testo completoBarner, Claudia Jane. "Part I. Coordination chemistry of high-valent osmium polyanionic chelating ligand complexes with imine, imido and nitrido ligands. : Part II. Asymmetric hydrogenation using a resolved chiral scandium hydride complex /". Diss., Pasadena, Calif. : California Institute of Technology, 1990. http://resolver.caltech.edu/CaltechETD:etd-06112007-095040.
Testo completoMagee, Chad Leroy Keller S. W. "The synthesis and characterization of 1,1'-disubstituted ferrocene imine Schiff base ligand systems for use as potential environmental heavy metal cationic sensors". Diss., Columbia, Mo. : University of Missouri--Columbia, 2008. http://hdl.handle.net/10355/7117.
Testo completoGunler, Zeynep Inci. "Synthesis Of N-(2-propylphenyl) Substituted Chiral Amino Alcohols And Their Usage In Enantioselective Diethylzinc Addition Reactions". Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613001/index.pdf.
Testo completointramolecular unsaturation transfer&rdquo
using cyclohexanone, propargyl bromide, and various chiral amino alcohols as starting components. These amino alcohols can be potential chiral ligands for many asymmetric transformation reactions. Therefore, their effectiveness as chiral ligands in diethylzinc addition to benzaldehyde and N-diphenylphosphinoyl imines were tested. Various parameters including temperature, solvent, ligand amount etc. were screened for the synthesized chiral ligands. In diethylzinc addition to benzaldehyde high enantioselectivity could not be obtained. When N-diphenylphosphinoyl imines were used as substrate good ee values up to 80% were achieved.
Pierre, Fabrice. "Synthese et reduction electrochimique de complexes (#5-cyclopentadienyl) (#6-arene) fer(ii)pf#6 porteurs d'une fonction imine ou nitrone en position benzylique du ligand arene". Rennes 1, 1997. https://tel.archives-ouvertes.fr/tel-00343810.
Testo completoTanh, Jeazet Harold Brice. "Metallo-supramolecular Architectures based on Multifunctional N-Donor Ligands". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-39665.
Testo completoMukherjee, Soumen. "Transition metal complexes with imine-phenolate and imino-benzosemiquinone ligands synthesis, characterization, and their catalytic reactivity /". [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=971568197.
Testo completoWietzke, Raphaël. "Complexation des éléments par des ligands tripodes azotés : application à l'extraction sélective des actinides(III)". Université Joseph Fourier (Grenoble), 1999. http://www.theses.fr/1999GRE10223.
Testo completoBoudier, Adrien. "Design, synthesis and characterization of new ligands and activators for the oligomerization of ethylene by iron complexes". Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00868786.
Testo completoFinn, Rachel Louise. "Studies on complexes of compartmental imine and amine ligands". Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364648.
Testo completoSilva, Manuel Mateus Webba da. "Synthetic and spectroscopic studies on organometallic complexes of imine ligands". Thesis, University of Exeter, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296312.
Testo completoNeshat, Abdollah. "Group V Imido Complexes Bearing Mono-Anionic Acetophenone Imine Ligands". University of Toledo / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1302269375.
Testo completoROSAR, VERA. "The importance of ligand structural diversity in palladium catalyzed polymerization". Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908017.
Testo completoThe main goal of the PhD research was the development of novel homogeneous catalysts for copolymerization of ethylene with polar vinyl monomers, such as acrylic esters, in order to obtain functionalized polyolefins with a controlled content of the inserted polar monomer. The project focused on the synthesis and characterization of palladium(II) complexes with novel non symmetric nitrogen-donor ligands of increasing complexity, and belonging either to the class of alpha-diimines or to the group of the pyridylimines. The catalytic behaviour of the synthesized palladium(II) complexes in the ethylene/methyl acrylate copolymerization was investigated in detail. Some of the catalysts were also applied to other reactions such as the CO/vinyl arene copolymerization and the bis-alkoxycarbonylation of alkenes, demonstrating the versatility of palladium catalysts with N-donor ligands.
Hanton, Martin John. "Coordination complexes of bidentate phosphino-imine ligands : synthesis, characterisation and reactivity". Thesis, University of Leicester, 2003. http://hdl.handle.net/2381/33724.
Testo completoGerlach, Daniela. "Neuartige höherkoordinierte Siliciumkomplexe mit Pyrrol-2-carbaldimin-Liganden". Doctoral thesis, Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2013. http://nbn-resolving.de/urn:nbn:de:bsz:105-qucosa-104526.
Testo completoGarrett, Andrew D. Templeton J. L. "Transformations of nitrile, amido, and imine ligands in Tp[prime] tungsten complexes". Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,810.
Testo completoTitle from electronic title page (viewed Dec. 18, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry." Discipline: Chemistry; Department/School: Chemistry. On t.p., [prime] is the symbol.
Pandrapragada, Ravi Kumar. "Synthesis and characterization of novel phosphinimine ligand systems for potential applications in radiopharmaceuticals". Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5100.
Testo completoThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed Nov. 1, 2007). Vita. Includes bibliographical references.
Mugo, Jane Ngima. "Metal complexes based on monomeric and dendrimeric pyrrole-imine ligands as catalytic precursors". Thesis, University of the Western Cape, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_7455_1242709415.
Testo completoOver the recent past, organometallic chemistry has grown and the impact of catalytic applications in various chemical technologies has rapidly evolved from the realm of academic laboratories into full-scale industrial processes. Pyrrole-imine ligands were prepared by condensation of pyrrole-2-carboxylaldehyde with propyl amine, 2,6-diisopropylanaline, poly(propylene) imine dendrimer and 3-aminopropyl-triethoxysilane to give the desired ligands in good yields. These ligands were charaterized via combination of techniques to establish the molecular structure. Microanalysis was performed to confirm the purity of the product.
Bonnet, Ludovic GreÌgoire. "New chiral N-heterocyclic carbene-imine ligands and their application to asymmetric catalysis". Thesis, University of Birmingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403052.
Testo completoProfirio, Daniel de Moraes 1989. "Atividades antibacteriana e citotóxica de um complexo de Au(III) contendo ligante pirrolil-imina". [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248530.
Testo completoDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química
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Resumo: Neste trabalho realizou-se a síntese de três ligantes contendo a unidade pirrolil-imina e de um complexo de Au(III). Os ligantes foram sintetizados partindo-se do pirrol-2-carboxaldeído e etilenodiamina ou orto-fenilenodiamina, obtendo-se assim o N,N'-bis(pirrol-2-il-metileno) etano-1,2-diamina (pyren), o N,N'-bis(pirrol-2-il-metileno)benzeno-1,2-diamina (bis-pyrophen), o N-(pirrol-2-il-metileno)benzeno-1,2-diamina (monopyrophen) e o complexo [Au(pyren)]PF6 como produtos. Os compostos foram caracterizados por análise elementar, MS, espectroscopia no IV e UV-Visível, RMN de H, C e HMBC H-N, cálculos teóricos por DFT e TD-DFT. Foram realizados também ensaios antibacterianos e citotóxicos com o complexo [Au(pyren)] e com o ligante pyren, sendo que o complexo apresentou maior atividade em ambos os ensaios comparado ao ligante. Com isso um mecanismo de ação via interação com o DNA foi investigado por estudos de fluorescência, ensaios de competição com brometo de etídio e espectroscopia de dicroísmo circular, revelando que o DNA é um possível alvo biológico do complexo
Abstract: In this work the syntheses of three ligands containing the pyrrolyl-imine unit and a Au(III) complex were performed. The ligands were synthesized starting from pyrrole-2-carboxaldehyde and ethylenediamine or ortho-phenylenediamine, to obtain N,N¿-bis (pyrrol-2-yl-methylene)ethane- 1,2-diamine (pyren), N,N¿-bis(pyrrol-2-yl-methylene)benzene-1,2-diamine (bis-pyrophen), N-(pyrrol-2-yl-methylene)benzene-1,2-diamine (mono-pyrophen) and the complex [Au(pyren)]PF6 as products. The compounds were characterized by elemental analysis, MS, IR, UV-Visible, H, C and (H-N) HMBC NMR spectroscopies and theoretical calculations by DFT and TD-DFT. Cytotoxic and antibacterial assays with [Au(pyren)] and the free ligand pyren were performed, and the complex showed a higher activity in both cases in comparison to the ligand. A mechanism of action via interaction with DNA was investigated by fluorescence techniques, competition studies with ethidium bromide and circular dichroism spectroscopy, showing that DNA is a potential biological target for the complex
Mestrado
Quimica Inorganica
Mestre em Química
Blackmore, Ian John. "The reactivity of the bis(imino)pyridine ligand towards alkylating agents and the role of acid in ligand exchange reactions". Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412026.
Testo completoMukiza, Janvier. "Rhenium complexes with pontentially multidentate ligands containing the amino, imino, hydroxy and thiol groups". Thesis, Nelson Mandela Metropolitan University, 2016. http://hdl.handle.net/10948/12308.
Testo completoKennedy, Margaret D. "Synthesis of and computational studies on C(s)- and C(1)-symmetric bis(imino) pyridine ligands". Click here for download, 2009. http://proquest.umi.com.ps2.villanova.edu/pqdweb?did=1786804491&sid=1&Fmt=2&clientId=3260&RQT=309&VName=PQD.
Testo completoVolbeda, Jeroen [Verfasser]. "The coordination chemistry of edge-bridged open indenyl and imidazolin-2-imine ligands / Jeroen Volbeda". München : Verlag Dr. Hut, 2014. http://d-nb.info/1058284908/34.
Testo completoOliveira, Fabrícia Alvisi de. "Participação do CD40L solúvel e da metaloproteinase de matriz -9 na resposta imune na leishmaniose visceral humana". Universidade Federal de Sergipe, 2016. https://ri.ufs.br/handle/riufs/3621.
Testo completoIn the present study, the sera levels of soluble CD40 ligand (sCD40L) and matrix metalloproteinase-9 (MMP-9) were quantified by Luminex assay in Visceral leishmaniasis patients before and during treatment follow-up and after regular antimony treatment and also in individuals exposed to infection, living in endemic areas. Different from the other molecules present in sera from classic VL patients, sCD40L and MMP-9 are fairly increased, and increase over time during the follow-up of VL patients undergoing antimony treatment. sCD40L and MMP-9 sera levels were also high in individuals living in endemic settings at high risk of infection (endemic controls). On the other hand, sCD40L and MMP-9 were not observed in sera from non-endemic controls, which are not exposed of infection. Additionally, negative correlations were found between spleen sizes and MMP-9 before treatment and sCD40L at day 15 of treatment. Negative correlations were also found between parasite load with both sCD40L and MMP-9. These findings indicate that both molecules can be used in monitoring therapeutic efficacy in VL. Furthermore, these data suggest a protective effect of these molecules, since the individuals exposed to infection without the symptoms of disease have high sera levels of sCD40L and MMP-9. These data were published in BMC Infectious diseases journal [1]. To confirm the protective effect of sCD40L present in sera of VL patients and determine if this molecule had biological activity, the ability of sera from patients containing high levels of this molecule sCD40L to control infection in vitro in Leishmania infantum infected macrophages, and the ability to induce cytokines production. Thereby, macrophages from of healthy donor were infected with Leishmnia infantum, and later incubated in presence of sera from individuals exposed to infection in presence of anti-CD40L. The infection was evaluated by counting of the number of infected macrophages/100 and the number of intracellular amastigotes/100 macrophages. The data showed that serum sCD40L decrease the number of infected macrophages and the number of intracellular amastigotes. The blockage of sCD40L activity with specific antibody, increase the infection. Moreover, the analysis of cytokines in supernatant of these macrophage cultures by Luminex assay demonstrated that sCD40L induces the IL-12, IL-23, IL-27, IL-15 e IL-1 production. The levels of these cytokines is inversely correlated with infection rate and the number of intracellular parasites from infected macrophages. A second manuscript with these data were published in PLOS One [2] . These results demonstrated that serum sCD40L from individuals exposed to VL improve the microbicide effect and the inflammatory cytokine production, suggesting its potential use in VL immunotherapy. Nevertheless, there is still a long way to be approached in future experimental and clinical studies.
No presente estudo, os níveis séricos dos marcadores inflamatórios CD40 ligante solúvel (sCD40L) e da metaloproteinase de matrix-9 (MMP-9) foram quantificados por Luminex nos pacientes com leishmaniose visceral antes, durante e após o tratamento com antimonial, e em indivíduos controles expostos à infecção, residindo em áreas endêmicas. Ao contrário das outras moléculas inflamatórias presentes nos soros de pacientes com LV, as moléculas sCD40L e MMP-9 apresentaram elevação moderada, havendo um aumento significativo de ambas no decorrer do tratamento com antimonial. Níveis séricos elevados de sCD40L e MMP-9 também foram encontrados nos indivíduos controles sem doença, provenientes de áreas endêmicas e expostos a infecção. Entretanto, o sCD40L e a MMP-9 não foram detectados nos soros de indivíduos de áreas não endêmicas, os quais não estão expostos a infecção. Adicionalmente, correlações negativas entre o tamanho do baço com a MMP-9 antes do tratamento e com o sCD40L 15 dias após o início do tratamento foram observadas, bem como correlações negativas entre ambas as moléculas com a carga parasitaria dos pacientes. Estes resultados indicam que estas moléculas podem ser utilizadas no monitoramento da eficácia terapêutica na leishmaniose visceral. Além disso, estes dados nos sugerem um efeito protetor dessas moléculas contra a doença, desde que os indivíduos expostos e sem a doença apresentaram concentrações elevadas dessas moléculas. Estes dados foram publicados no BMC Infectious diseases [1]. Para confirmar o efeito protetor do sCD40L e investigar se a molécula presente nos soros dos pacientes com LV tinha atividade biológica, foi avaliado se o sCD40L presente no soro dos indivíduos infectados teria ação na resposta leishmanicida e na produção de citocinas por macrófagos infectados por Leishmania infantum. Dessa forma, macrófagos de doadores normais foram infectados com L. infantum e posteriormente incubados com soro de indivíduos expostos a infecção na presença de anti-CD40L. A avaliação da infecção através da contagem de células infectadas e do número de parasitas intracelulares demonstrou que a presença do sCD40L sérico diminui o número de macrófagos infectados e o número de amastigotas intracelulares. O bloqueio da atividade do sCD40L com anticorpo específico reverteu este efeito, aumentando a infecção. Além disso, a análise de citocinas no sobrenadante das culturas de macrófagos por Luminex mostrou que a adição de sCD40L induziu a produção de IL-12, IL- 23, IL-27, IL-15 e IL-1. As concentrações destas citocinas correlacionaram-se inversamente com as taxas de infecção e com o número de parasitas intracelulares nos macrófagos infectados. Um segundo artigo com estes resultados foi publicado na PLOS One [2]. Estes resultados demonstram que o sCD40L sérico dos indivíduos expostos à LV melhora a capacidade microbicida e a produção de citocinas inflamatórias, sugerindo seu potencial uso na imunoterapia na LV humana, embora este seja um longo caminho a ser abordado em estudos futuros experimentais e clínicos.
El, Hajjaji Samir. "Asymmetric transition metal-catalyzed alkyl addition to imines with chiral phosphine ligands". Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/11185/.
Testo completoAlhalafi, Mona Hanash A. "Pyridone-substituted pyridyl imines as functionalised ligands in coordination chemistry and catalysis". Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/42404.
Testo completoMotoboli, Mpho Princess. "Synthesis and modelling of imine derivatives as ligands for Grubbs type pre–catalysts / by Mpho Princess Motoboli". Thesis, North-West University, 2010. http://hdl.handle.net/10394/4633.
Testo completoThesis (M.Sc. (Chemistry))--North-West University, Potchefstroom Campus, 2011.
Salazar, Garza Gustavo Adolfo. "Microwave-Assisted Synthesis and Photophysical Properties of Poly-Imine Ambipolar Ligands and Their Rhenium(I) Carbonyl Complexes". Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc1011818/.
Testo completoHe, Fan. "Transition metal complexes with N-heterocyclic carbene ligands : synthesis and reactivity". Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF031/document.
Testo completoThe purpose of this work is the synthesis of complexes containing imine-functionalized protic NHC ligands in order to further develop synthetic methodologies giving access to pNHC, C-bound ‘anionic’ imidazolide, and homo- and heterodinuclear complexes. In the case of imidazoles without functional group, deprotonation with n-butyl lithium afforded (1-aryl-1H-imidazol-2-yl)lithium in good yield. Reaction of (1-aryl-1H-imidazol-2-yl)lithium with [Ir(cod)(μ-Cl)]2 or [Rh(cod)(μ-Cl)]2 yielded a doubly C2,N3-bridged dinuclear complex. In the case of imine-functionalized imidazole, the Ir(I) N-bound imidazole complex can tautomerize to Ir(I) imine-functionalized pNHC complex chloride abstraction at room temperature, while in the Rh(I) analog the tautomerization can be achieved at 110 °C. In situ deprotonation of the N-bound imidazole Ir(I) or Rh(I) complexes, followed by addition of [Ir(cod)(μ-Cl)]2 or [Rh(cod)(μ-Cl)]2 led to the isolation of homo- and heterodinuclear complexes. The metalation of imine-functionalized imidazolium salts is also an effective procedure for synthesis of pNHC metal complexes, and it was extended from bidentate to pincer-type pNHC complexes
Le, Fur Nicolas. "Synthèse et métallation des sulfoxydes benzodiaziniques. Synthèse asymétrique de sulfoxydes aromatiques, métallation et applications". Rouen, 2004. http://www.theses.fr/2004ROUES046.
Testo completoThe syntheses of 15 new sulfinylbenzodiazines have been described. Their metalation was studied and confirmed the good ortho directing power as well as the leaving group abilities of the sulfoxide groups. The use of prochiral electrophiles (aldehydes, imines) has highlighted modest to high diastereoselectivities during the addition step depending on the steric hindrance of the electrophile. Thermal decomposition of the tert-butanesulfinyl group to sulfenic acid has been observed leading to cinnolinic benzisothiazoline-like structures. In a second part, several enantiopure aromatic tert-butanesulfoxides have been synthesised. They were prepared by the substitution of tert-butanethiosulfinate by an aryllithium (benzene, naphthalène, pyridine, quinoline et pyridazine). The subsequent metalation of these molecules was studied and a complete asymmetric induction of the tert-butanesulfinyl group was found when prochiral imines were used. Application of these new chiral amino-sulfoxides as enantiopure amine precursors or as new N-S type ligands for asymmetric catalysis have been explored. Finally, thermal cyclisation of these amino-sulfoxides led to chiral analogs of benzisothiazoline structures
De, Jongh Leigh-Anne. "Imine-donor complexes with group 6 and group 11 transition metals : coordination and dynamics". Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/2001.
Testo completoIn this study the coordination of ligands with several coordination sites, 2-aminoazoles (2- amino-4-methylthiazole), 2-aminobenzothiazole, 2-aminobenzoimidazole and 2- aminothiazoline and a biguanidine (N-(2-methylphenyl)imidodicarbonimidic diamide) to soft metal centres [gold(I) (group 11), chromium(0) (group 6) and tungsten (0) (group 6)] was investigated. The aminoazoles have three coordination sites, an exocyclic amine nitrogen, an endocyclic imine nitrogen and an endocyclic thioether sulphur. The biguanidine ligand has three sites for deprotonation, one central amine and two imine nitrogens, and at least five sites available for nitrogen coordination.
Perman, Jason Alexander. "Solid-State Synthesis of Imide Ligands for the Self-Assembly of Metal-Organic Materials". Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3747.
Testo completoAal, Frouke [Verfasser]. "Synthese und Koordinationschemie mehrzähniger Imidazolin-2-imin-Liganden / Frouke Aal". München : Verlag Dr. Hut, 2013. http://d-nb.info/1042878528/34.
Testo completoWu, Xianghong Gorden Anne Elizabeth. "Synthesis and applications of 2-quinoxalinol salens and their metal complexes". Auburn, Ala., 2008. http://hdl.handle.net/10415/1425.
Testo completoWinston, Scott. "Functionlised N-heterocyclic carbenes and amido imino mixed donors as supporting ligands in organometallic catalysis". Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274654.
Testo completoReich, Blair Jesse Ellyn. "Cyanide-catalyzed C-C bond formation: synthesis of novel compounds, materials and ligands for homogeneous catalysis". Texas A&M University, 2005. http://hdl.handle.net/1969.1/4987.
Testo completoFels, Sabine. "Höherkoordinierte Komplexverbindungen des Siliciums, Germaniums und Zinns mit chiralen O,N,O´-Liganden". Doctoral thesis, Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2016. http://nbn-resolving.de/urn:nbn:de:bsz:105-qucosa-211546.
Testo completoKokel, Nicolas. "Réductions asymétriques de doubles liaisons catalysées par des complexes du rhodium coordinés par les ligands chiraux aminophosphinephosphinites". Lille 1, 1988. http://www.theses.fr/1988LIL10068.
Testo completoBheeter, Linus Paulin. "catalyseurs à base de ligands carbène N-hétérocycliques dérivés de fer et de nickel pour les réactions catalytiques d'hydrosilylation et d'hydroboration". Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1S182.
Testo completoThe research work described in this manuscript has for main objective the development of new homogeneous catalytic systems based on N-heterocyclic carbene (NHC) iron and nickel complexes for hydrosilyation and borylation reactions. The first chapter describes the use of [Cp(NHC)Fe(CO)₂][X] (X = I, PF₆) complexes bearing benzimidazole or imidazole NHC type ligands for hydrosilylation of benzaldehyde and acetophenone. In a second chapter, we have shown that half-sandwich NHC-nickel complexes in the presence of a catalytic amount of NaHBEt3 can be efficient catalysts for the reduction of aldehydes, ketones, aldimines and ketimines in the presence of diphenylsilane. In the last chapter, two new series of non-classical NHC-nickel triazole complexes had been developed: (i) one series with half sandwich NHC-nickel triazole complexes and (ii) another one based on chelating anionic amido-functionalized N-heterocyclic carbene nickel complexes. The two series of complexes were then evaluated in catalytic borylation cross coupling reaction
Cao, Yu. "I. Synthesis Of Anthraquinone Derivatives For Electron Transfer Studies In DNA. II. Characterization Of The Interaction Between Heme And Proteins". Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/chemistry_diss/55.
Testo completoTrifonova, Anna. "Synthesis of Novel Chiral Bicyclic Ligands and their Application in Iridium-Catalyzed Reactions". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5783.
Testo completoGietz, Twyla Mae, e University of Lethbridge Faculty of Arts and Science. "Lithium complexes of ketoimines and novel alkynyl imines and diimines : discoveries in the attempted synthesis of PACNAC". Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistry, c2010, 2010. http://hdl.handle.net/10133/2481.
Testo completoxvi, 134 leaves : ill. (some col.) ; 29 cm + 1 CD-ROM
Zanin, Maria Eduarda. "Pneumopatia experimental : expressão genica de Fas, Fas-ligante, Bcl-w e citocinas em pulmões de camundongos da linhagem /balb/c submetidos a exposição fungica (Lentinus edodes - Shitake e Aspergillus fumigatus)". [s.n.], 2002. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311775.
Testo completoDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: Atualmente, o interesse pelas reações provocadas pelo fungo Lentinus edodes, cogumelo Shiitake, tem aumentado acompanhando sua popularidade nos países do Ocidente, onde ele é cada vez mais empregado na culinária e como ¿elixir de boa saúde¿. Paralelamente, tem crescido o número de relatos de reações alérgicas provocadas pelo consumo e manuseio do cogumelo, principalmente em produtores, que entram em contato com os esporos, facilmente inalados, e desenvolvem reações como tosse, calafrios e febre após o contato. As respostas iniciadas após a exposição fúngica devem-se aos sistemas de modulação da resposta imune, tais como subtipos de célula T recrutados para a resposta (TH1 ou TH2), tipos de citocinas secretadas e apoptose. Nosso estudo foi direcionado para a observação dos mecanismos de resistência e susceptibilidade às reações pulmonares e sistêmicas (células esplênicas) contra o Shiitake, baseados na expressão gênica das citocinas IL-2, IL-4, IL-5, IL-12, TNF-a e IFN-g, e componentes apoptóticos Fas, Fas¿Ligante (Fas-L) e Bcl-w nos camundongos BALB/c submetidos à exposição de esporos de Shiitake e Aspergillus fumigatus, utilizado como parâmetro de comparação, uma vez que as reações por ele provocadas são amplamente descritas na literatura. Dessa forma, os resultados obtidos evidenciam a modulação direcionada para células TH1 provocadas pelos esporos de Shiitake e Aspergillus fumigatus nos animais estudados, com expressão aumentada das citocinas IL-12, TNF-a e IFN-g, tanto local quanto sistemicamente, além do aumento de linfócitos nos pulmões. O estudo dos componentes apoptóticos revelou a expressão da molécula Fas apenas nos pulmões e células esplênicas dos animais expostos aos esporos de Shiitake e Aspergillus fumigatus, com observação de apoptose in situ pelas técnicas de Feulgen e TUNEL realizadas nos pulmões desses animais, sugerindo a modulação desses fungos na ocorrência da apoptose
Abstract: The Lentinus edodes (Shiitake mushroom) is one the most popular edible mushrooms in the world. The indoor cultivation of Shiitake can lead to allergic symptoms in mushroom worker¿s, in contrast to outdoor cultivation where problems occur sporadically. Simultaneously have been growth relates of allergic reaction elicited by the consumption and handily of this mushroom, mainly between workers which inhaled the spores released during manipulation of Shiitake. These spores reaching the terminal area of the lung producing symptoms that suggest a delayed hypersensibility reaction with clinical symptoms of dispnea, cough, chills, and fever. The immune response after fungal exposition is attributed to the modulation of this response by the T cells subsets recruited (TH1 or TH2), cytokines release and apoptosis. The aim of this study was to verify the resistance and susceptibility to the Shiitake by the analyzes of molecular expression of cytokines IL-2, IL-4, Il-5, IL-12, TNF-a and IFN-g and apoptotic components Fas, Fas-L and Bcl-w, in lung and spleen cells of BALB/c submitted to Shiitake and Aspergillus fumigatus spores exposure, as a positive control of response. We found a over expression of cytokines IL-12, TNF-a, and IFN-g, in both compartments, systemic and locally (spleen cells and lung respectively), moreover, the lymphocytes were increased, suggesting the TH1 driving response evoked by exposure to Aspergillus fumigatus and Shiitake spores. The study of apoptotic components demonstrated the expression of Fas only in lungs and spleen cells of exposed animals to spores. The presence of apoptosis in lung was confirmed by the Feulgen and TUNEL techniques, suggesting the fungal modulation of apoptosis
Mestrado
Clinica Medica
Mestre em Clinica Medica
Cheruku, Pradeep. "Asymmetric Hydrogenations : Syntheses of Ligands and Expansion of Substrate Scope". Doctoral thesis, Uppsala universitet, Institutionen för biokemi och organisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9353.
Testo completoWegermann, Camila Anchau. "Interações de ligantes imínicos com peptídeos amiloides e metais essenciais implicados em processos neurodegenerativos". Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-20072018-093655/.
Testo completoChelation therapy has been considered in the literature an important tool in neurodegenerative processes like Alzheimer disease (AD). This disease is characterized by aggregation of β-amyloid peptides that seems to be improved in the presence of metal ions, particularly copper, zinc and iron. Several compounds have been tested and reported as competitive ligands to withdrawal these metal ions from protein aggregates in pathologic conditions, in the \"amyloid cascade hypothesis\". The present project aims to investigate the reactivity of imine ligands, particularly those derived from oxindoles, in the chelation of copper(II) and zinc(II) ions trying to inhibit or avoid aggregate formation related to AD. Six iminic compounds were synthesized, being two of them hydrazones: isahim and isahpy and four Schiff bases: isapn, misapn, isaen, and misaen. The compounds were characterized by spectroscopic analysis (FTIR, NMR, UV/VIS), elemental analysis CHN and mass spectrometry ESI-MS/MS. The corresponding stability constants (log β 2,7-5,1) for each complex formation [ML]2+ as well as for the adduct [(Aβ1-16)2•isahim] in aqueous solution were determined by UV/VIS spectroscopy. Interactions of compounds isapn, misapn and isahim with the Aβ1-16 peptide were detected and analyzed by 1H NMR spectroscopy, indicating a strong interaction among the compounds and the histidines His6, His13 e His14 as well as the carboxylate residues in the peptides. The ligands efficiency toward the inhibition aggregation process for the Aβ1-40 peptide were evaluated in the presence, and in absence of Cu2+ or Zn2+ ions by turbidimetry. Computational calculations (docking and molecular dynamics) indicated that the interaction of the imine ligand with the Aβ1-16 peptide occurs in the metal coordination sites. The results indicate that these imine compounds studied may act as efficient inhibitors of amyloid peptides implicated in AD.
Diesen, Jarle Sidney. "Asymmetric Hydrogenations of Imines, Vinyl Fluorides, Enol Phosphinates and Other Alkenes Using N,P-Ligated Iridium Complexes". Doctoral thesis, Uppsala universitet, Avdelningen för organisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8971.
Testo completoHernández, Olmos Victor. "Diseño de ligandos quirales con estructura de imino- y aminopiridina. Aplicación a la reacción de Henry Enantioselectiva". Doctoral thesis, Universitat de València, 2010. http://hdl.handle.net/10803/41726.
Testo completoCettolin, M. "IRON AND RUTHENIUM CATALYSTS FOR THE REDUCTION OF C=O AND C=N BONDS". Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/543550.
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