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1
Glaeser, Sharon S., Katie L. Edwards, Nadja Wielebnowski e Janine L. Brown. "Effects of physiological changes and social life events on adrenal glucocorticoid activity in female zoo-housed Asian elephants (Elephas maximus)". PLOS ONE 15, n. 11 (6 novembre 2020): e0241910. http://dx.doi.org/10.1371/journal.pone.0241910.
Testo completoAbstract (sommario):
Ensuring good health and welfare is an increasingly important consideration for conservation of endangered species and includes breeding of individuals managed under human care. Understanding how factors in the captive environment affect individual animal wellbeing can be aided by long-term monitoring of biological functioning. This study involved longitudinal assessments (4 to 28 years) of reproductive and adrenal hormones in zoo-housed female Asian elephants (Elephas maximus) (age range 4 to ~71 years) to elucidate patterns in adrenal glucocorticoid (GC) activity in association with reproductive and demographic factors, and examine individual response to major social changes. Concentrations of serum and urinary cortisol covaried more consistently with physiological changes (ovarian cycle phase, puberty, pregnancy, lactational anestrus, and age) than with social life events (births, deaths, and facility transfers). Cortisol fluctuated across the ovarian cycle with mean concentrations being higher in the follicular than in the luteal phase, and concentrations were highest in lactational anestrous compared to all other reproductive states. The elephants in this study exhibited substantial individuality in adrenal GC response to major social change, reinforcing the need to assess welfare on an individual basis and to consider factors influencing the impact of perceived stressors, such as social relationships, social support, temperament, and life history. Outcomes from this study deepen our understanding of Asian elephant physiology and highlight the importance of taking intrinsic patterns of hormone secretion into account when evaluating the impact of external factors. Finally, a better understanding of the impact of social change and resiliency in response to real and perceived stressors allows us to improve social management to enhance welfare in both captive settings and free-ranging environments.
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Bernhardt, Joey R., Mary I. O'Connor, Jennifer M. Sunday e Andrew Gonzalez. "Life in fluctuating environments". Philosophical Transactions of the Royal Society B: Biological Sciences 375, n. 1814 (2 novembre 2020): 20190454. http://dx.doi.org/10.1098/rstb.2019.0454.
Testo completoAbstract (sommario):
Variability in the environment defines the structure and dynamics of all living systems, from organisms to ecosystems. Species have evolved traits and strategies that allow them to detect, exploit and predict the changing environment. These traits allow organisms to maintain steady internal conditions required for physiological functioning through feedback mechanisms that allow internal conditions to remain at or near a set-point despite a fluctuating environment. In addition to feedback, many organisms have evolved feedforward processes, which allow them to adjust in anticipation of an expected future state of the environment. Here we provide a framework describing how feedback and feedforward mechanisms operating within organisms can generate effects across scales of organization, and how they allow living systems to persist in fluctuating environments. Daily, seasonal and multi-year cycles provide cues that organisms use to anticipate changes in physiologically relevant environmental conditions. Using feedforward mechanisms, organisms can exploit correlations in environmental variables to prepare for anticipated future changes. Strategies to obtain, store and act on information about the conditional nature of future events are advantageous and are evidenced in widespread phenotypes such as circadian clocks, social behaviour, diapause and migrations. Humans are altering the ways in which the environment fluctuates, causing correlations between environmental variables to become decoupled, decreasing the reliability of cues. Human-induced environmental change is also altering sensory environments and the ability of organisms to detect cues. Recognizing that living systems combine feedback and feedforward processes is essential to understanding their responses to current and future regimes of environmental fluctuations. This article is part of the theme issue ‘Integrative research perspectives on marine conservation’.
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LESERMAN, J., J. M. PETITTO, H. GU, B. N. GAYNES, J. BARROSO, R. N. GOLDEN, D. O. PERKINS, J. D. FOLDS e D. L. EVANS. "Progression to AIDS, a clinical AIDS condition and mortality: psychosocial and physiological predictors". Psychological Medicine 32, n. 6 (agosto 2002): 1059–73. http://dx.doi.org/10.1017/s0033291702005949.
Testo completoAbstract (sommario):
Background. The primary aim of this study is to examine prospectively the association of stressful life events, social support, depressive symptoms, anger, serum cortisol and lymphocyte subsets with changes in multiple measures of human immunodeficiency virus (HIV) disease progression.Methods. Ninety-six HIV-infected gay men without symptoms or anti-retroviral medication use at baseline were studied every 6 months for up to 9 years. Disease progression was defined in three ways using the Centers for Disease Control (CDC) classifications (e.g. AIDS, clinical AIDS condition and mortality). Cox regression models with time-dependent covariates were used, adjusting for control variables (e.g. race, age, baseline, CD4 T cells and viral load, number of anti-retroviral medications).Results. Higher cumulative average stressful life events and lower cumulative average social support predicted faster progression to both the CDC AIDS classification and a clinical AIDS condition. Higher anger scores and CD8 T cells were associated with faster progression to AIDS, and depressive symptoms were associated with faster development of an AIDS clinical condition. Higher levels of serum cortisol predicted all three measures of disease progression.Conclusions. These results suggest that stressful life events, dysphoric mood and limited social support are associated with more rapid clinical progression in HIV infection, with serum cortisol also exerting an independent effect on disease progression.
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Meylan, Sandrine, Donald B. Miles e Jean Clobert. "Hormonally mediated maternal effects, individual strategy and global change". Philosophical Transactions of the Royal Society B: Biological Sciences 367, n. 1596 (19 giugno 2012): 1647–64. http://dx.doi.org/10.1098/rstb.2012.0020.
Testo completoAbstract (sommario):
A challenge to ecologists and evolutionary biologists is predicting organismal responses to the anticipated changes to global ecosystems through climate change. Most evidence suggests that short-term global change may involve increasing occurrences of extreme events, therefore the immediate response of individuals will be determined by physiological capacities and life-history adaptations to cope with extreme environmental conditions. Here, we consider the role of hormones and maternal effects in determining the persistence of species in altered environments. Hormones, specifically steroids, are critical for patterning the behaviour and morphology of parents and their offspring. Hence, steroids have a pervasive influence on multiple aspects of the offspring phenotype over its lifespan. Stress hormones, e.g. glucocorticoids, modulate and perturb phenotypes both early in development and later into adulthood. Females exposed to abiotic stressors during reproduction may alter the phenotypes by manipulation of hormones to the embryos. Thus, hormone-mediated maternal effects, which generate phenotypic plasticity, may be one avenue for coping with global change. Variation in exposure to hormones during development influences both the propensity to disperse, which alters metapopulation dynamics, and population dynamics, by affecting either recruitment to the population or subsequent life-history characteristics of the offspring. We suggest that hormones may be an informative index to the potential for populations to adapt to changing environments.
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Cohen, Miri, Liora Sklair-Tavron e Shimon Pollack. "The Association of Forskolin-Stimulated Cyclic AMP Levels in Peripheral Blood Mononuclear Cells of Healthy People with Depressive Mood and Sense of Coherence". Journal of Psychophysiology 18, n. 4 (gennaio 2004): 177–83. http://dx.doi.org/10.1027/0269-8803.18.4.177.
Testo completoAbstract (sommario):
Abstract: Background: Depressive mood exerts a suppressive effect on immune functions, mediated through neuro-immune processes. Research suggests a protective effect of sense of coherence (SOC) on psychological and physical health in face of stressful life events. Cyclic adenosine monophosphate (cAMP) is a cellular second messenger that is coupled to certain receptors expressed on peripheral blood mononuclear cells (PBMC). By interfering with the neuro-endocrine-immune axis, depressive mood may induce changes in intracellular cAMP levels in PBMC. Aims of study: To examine a possible association of SOC, stressful life events during the previous year, depressive mood, and cAMP levels. Methods: Fifteen male volunteers participated in the study. They completed the SOC and Zung's depression questionnaires and stressful life events inventory. Basic cAMP level and forskolin-stimulated cAMP production were measured in PBMC. Results: Forskolin-stimulated cAMP production was significantly higher in individuals who reported higher depressive mood, more stressful life events, or lower SOC scores. SOC scores explained 40% of forskolin-stimulated cAMP production. Basal cAMP levels could not be correlated with psychological scores. Age or education level did not affect forskolin-stimulated or basal cAMP levels. Conclusions: Our data suggest that high forskolin-stimulated cAMP production in PBMC is associated with low SOC, which points to availability of personal resources for coping with stressful life events. Further examination of the possible mediating role of SOC in relation to depressive mood and neuroimmune functions is needed.
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Martinez, J., e S. Merino. "Host-parasite interactions under extreme climatic conditions". Current Zoology 57, n. 3 (1 giugno 2011): 390–405. http://dx.doi.org/10.1093/czoolo/57.3.390.
Testo completoAbstract (sommario):
Abstract The effect that climatic changes can exert on parasitic interactions represents a multifactor problem whose results are difficult to predict. The actual impact of changes will depend on their magnitude and the physiological tolerance of affected organisms. When the change is considered extreme (i.e. unusual weather events that are at the extremes of the historical distribution for a given area), the probability of an alteration in an organisms’ homeostasis increases dramatically. However, factors determining the altered dynamics of host-parasite interactions due to an extreme change are the same as those acting in response to changes of lower magnitude. Only a deep knowledge of these factors will help to produce more accurate predictive models for the effects of extreme changes on parasitic interactions. Extreme environmental conditions may affect pathogens directly when they include free-living stages in their life-cycles and indirectly through reduced resource availability for hosts and thus reduced ability to produce efficient anti-parasite defenses, or by effects on host density affecting transmission dynamics of diseases or the frequency of intraspecific contact. What are the consequences for host-parasite interactions? Here we summarize the present knowledge on three principal factors in determining host-parasite associations; biodiversity, population density and immunocompetence. In addition, we analyzed examples of the effects of environmental alteration of anthropogenic origin on parasitic systems because the effects are analogous to that exerted by an extreme climatic change.
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Uddin, Md Nagim, Tutul Kumar Saha, Myiesha Rayzil Hossain, SM Fakrul Islam e Zakir Hossain. "Constraints to climate change adaptation and livelihood challenges: perspectives from the Sundarbans fishers' community in Bangladesh". Asian Journal of Medical and Biological Research 8, n. 2 (26 giugno 2022): 103–14. http://dx.doi.org/10.3329/ajmbr.v8i2.60083.
Testo completoAbstract (sommario):
Fishers' are first-line observers of changes in the Sundarbans region and are among the first to be affected by the changes that occurred. In the Sundarbans fishers' communities, transformations of society have always been a part of life. In contrast, environmental changes were always interim and reversible, allowing them to understand and identify with the Sundarbans ecosystems as food and life providers. In this study, fishers' observations on climate change impacts and their livelihoods were compiled and analysed using a structured questionnaire in accordance with the tenets of grounded theory. The observations of fishers from the region of the Sundarbans demonstrated a rise in the frequency of extreme weather events caused by rising temperatures and changes in the weather pattern. Physical components such as rainfall, coastal erosion, sea-level rise, siltation alterations in fish species distribution ranges, and migratory spawning behaviours were also affected by changes in the region's weather and climate. As salinity levels rose, the diversity and productivity of river ecosystems were affected, particularly in the most vulnerable areas. As a result, river freshwater flow decreased over time. A high rate of siltation in rivers and river mouths was considered another major concern that led to seasonal flooding due to its low freshwater upstream flow rate. The Sundarbans region provides a vast array of resources for diversifying fishers' livelihoods, but climate change is diminishing these alternatives due to more frequent catastrophic events. Specifically, climate change limits the resilience of fishers' communities, restricting opportunities for diversification or forcing them to leave their homes or villages. Climate change generated an environment that was generally unfavourable for all fishing communities. In order to survive in an unfavourable environment, the social well-being of fishers (mostly women and children) was negatively impacted by a variety of challenges, including disease, lack of potable water, malnutrition, sanitary difficulties, lack of electricity, lack of food and clothing, lack of proper medical care, and so on. To evaluate the effects of climate change on fisheries in the study area, the biodiversity, abundance, and production of most freshwater species are drastically reduced due to the destruction of spawning grounds, a transition in the spawning season, and the obstruction of fish migration. The findings of this study show that the climate and livelihood conditions of fishers in the Sundarbans region have changed significantly over the past few decades. Regardless of GOs and NGOs taking the required steps, proper implementation of interdisciplinary adaptive policy and regular monitoring in the Sundarbans fisher's community in Bangladesh could effectively reduce climate change impacts and improve livelihood conditions. Asian J. Med. Biol. Res. 2022, 8 (2), 103-114
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van Halem, Sjoerd, Eeske van Roekel, Lara Kroencke, Niclas Kuper e Jaap Denissen. "Moments that Matter? On the Complexity of using Triggers Based on Skin Conductance to Sample Arousing Events within an Experience Sampling Framework". European Journal of Personality 34, n. 5 (settembre 2020): 794–807. http://dx.doi.org/10.1002/per.2252.
Testo completoAbstract (sommario):
To sample situations that are psychologically arousing in daily life, we implemented an experience sampling strategy in which 82 Dutch young adults ( Mage = 20.73) were triggered based on random time intervals and based on physiological skin conductance scores across a period of 5 days. When triggered, participants had to fill in short surveys on affect, situational characteristics and event characteristics on their smartphone. We found theoretically expected relationships between the skin conductance signal on the one hand and self–reported arousal and positive energy (e.g. energetic and enthusiastic) on the other hand, although effect sizes were small. Unexpectedly, none of the negative affective scales (i.e. irritation, anxiety, and negative valence) were predicted by skin conductance levels. Despite the (partial) validity of the signal, a simple algorithm that triggered the survey based on relative increases of skin conductance levels produced counterintuitive results due to a dependence between level and slope. Additional exploratory analyses highlighted other skin conductance signal characteristics (i.e. autocorrelation, number of peaks, and change points) that might be worth examining when designing future algorithms to sample arousing moments. Overall, our experiences highlight not only the promise but also the complexity of real–time measurement of physiological processes in daily life. © 2020 The Authors. European Journal of Personality published by John Wiley & Sons Ltd on behalf of European Association of Personality Psychology
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Glaeser, Sharon S., Katie L. Edwards, Stephen Paris, Candace Scarlata, Bob Lee, Nadja Wielebnowski, Shawn Finnell, Chaleamchat Somgird e Janine L. Brown. "Characterization of Longitudinal Testosterone, Cortisol, and Musth in Male Asian Elephants (Elephas maximus), Effects of Aging, and Adrenal Responses to Social Changes and Health Events". Animals 12, n. 10 (23 maggio 2022): 1332. http://dx.doi.org/10.3390/ani12101332.
Testo completoAbstract (sommario):
The conservation of endangered species and sustainability of managed populations requires considerations to ensure the health and welfare of individuals. Male elephants experience a biological phenomenon called “musth”, which is characterized by increased testosterone production, temporal gland secretion and urine dribbling, heightened aggression and sexual behavior, and therefore can pose unique challenges for human safety and animal welfare. This study characterized longitudinal (9 to 22 years) patterns of circulating testosterone and cortisol in relation to musth in four adult Asian elephant bulls spanning ages from 12 to 54 years. Age-related effects on musth activity and adrenal responses to social changes and clinical health events were also examined. All bulls exhibited regular annual musth cycles. Circulating cortisol covaried positively with testosterone and musth, highlighting intrinsic patterns that should be considered when evaluating the impact of social, health, and environmental changes on adrenal glucocorticoid activity. Except for an end-of-life cortisol increase in one bull, there was no clear evidence of chronically elevated cortisol secretion outside of musth in any individual. Testosterone decreased with age in sexually mature bulls, whereas age-related changes in cortisol varied across individuals, with the three older bulls showing the greatest rate of change during musth versus inter-musth periods. In contrast to physiological factors, there was no evidence of social factors, such as addition of a new male and death of male herdmates, impacting adrenal glucocorticoid activity in these bulls in the short term. Changes in cortisol were associated with treatment for Mycobacterium tuberculosis (M. tb) in two bulls, increasing after start of treatment and decreasing with cessation of treatment, but were not clearly associated with activation of disease. This study highlights the importance of longitudinal hormone monitoring to track changes in physiological function and responses to social, health, and environmental change in elephant bulls, which is important for making more informed decisions on how to manage male elephants under varying degrees of human care to ensure welfare and safety.
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Gunderson, Alex R., Amélie Fargevieille e Daniel A. Warner. "Egg incubation temperature does not influence adult heat tolerance in the lizard Anolis sagrei". Biology Letters 16, n. 1 (gennaio 2020): 20190716. http://dx.doi.org/10.1098/rsbl.2019.0716.
Testo completoAbstract (sommario):
Extreme heat events are becoming more common as a result of anthropogenic global change. Developmental plasticity in physiological thermal limits could help mitigate the consequences of thermal extremes, but data on the effects of early temperature exposure on thermal limits later in life are rare, especially for vertebrate ectotherms. We conducted an experiment that to our knowledge is the first to isolate the effect of egg (i.e. embryonic) thermal conditions on adult heat tolerance in a reptile. Eggs of the lizard Anolis sagrei were incubated under one of three fluctuating thermal regimes that mimicked natural nest environments and differed in mean and maximum temperatures. After emergence, all hatchlings were raised under common garden conditions until reproductive maturity, at which point heat tolerance was measured. Egg mortality was highest in the warmest treatment, and hatchlings from the warmest treatment tended to have greater mortality than those from the cooler treatments. Despite evidence that incubation temperatures were stressful, we found no evidence that incubation treatment influenced adult heat tolerance. Our results are consistent with a low capacity for organisms to increase their physiological heat tolerance via plasticity, and emphasize the importance of behavioural and evolutionary processes as mechanisms of resilience to extreme heat.
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Benton, Michael J. "Hyperthermal-driven mass extinctions: killing models during the Permian–Triassic mass extinction". Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 376, n. 2130 (3 settembre 2018): 20170076. http://dx.doi.org/10.1098/rsta.2017.0076.
Testo completoAbstract (sommario):
Many mass extinctions of life in the sea and on land have been attributed to geologically rapid heating, and in the case of the Permian–Triassic and others, driven by large igneous province volcanism. The Siberian Traps eruptions raised ambient temperatures to 35–40°C. A key question is how massive eruptions during these events, and others, could have killed life in the sea and on land; proposed killers are reviewed here. In the oceans, benthos and plankton were killed by anoxia–euxinia and lethal heating, respectively, and the habitable depth zone was massively reduced. On land, the combination of extreme heating and drought reduced the habitable land area, and acid rain stripped forests and soils. Physiological experiments show that some animals can adapt to temperature rises of a few degrees, and that some can survive short episodes of increases of 10°C. However, most plants and animals suffer major physiological damage at temperatures of 35–40°C. Studies of the effects of extreme physical conditions on modern organisms, as well as assumptions about rates of environmental change, give direct evidence of likely killing effects deriving from hyperthermals of the past. This article is part of a discussion meeting issue ‘Hyperthermals: rapid and extreme global warming in our geological past’.
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Dionne, Janis M. "Determinants of Blood Pressure in Neonates and Infants". Hypertension 77, n. 3 (3 marzo 2021): 781–87. http://dx.doi.org/10.1161/hypertensionaha.120.14587.
Testo completoAbstract (sommario):
The blood pressure (BP) of neonates, especially those born premature, changes rapidly over the first days and weeks of life. Neonatal BPs may be affected by maternal factors, perinatal factors or events, and intrinsic or extrinsic infant factors. Unfortunately, the effect of many maternal health and disease states has only been studied in small numbers or has shown conflicting results. Many events around the time of delivery have the potential to influence the neonatal BP, and while definitive studies are often lacking, some observational data support physiological expectations. The strongest determinants of neonatal BP are the infant factors of gestational age at birth, birth weight, and postmenstrual age. Understanding the expected pattern of BP changes, identifying the potential influencing factors, and accurately measuring the BP are all essential to determine whether there is a BP abnormality present but are also more complex in the neonatal population. This review describes the evidence for maternal conditions, perinatal events, and infant factors to affect neonatal BP. It also explains what is currently known about the changing BP patterns in neonates including those born preterm. In addition, by examining the physiological process of hemodynamic adaptation to the extrauterine environment and compensatory cardiovascular responses, we can gain insight into the expected and unexpected vascular responses, making the variability of neonatal BP seem a little more predictable.
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Forrest, Jessica, e Abraham J. Miller-Rushing. "Toward a synthetic understanding of the role of phenology in ecology and evolution". Philosophical Transactions of the Royal Society B: Biological Sciences 365, n. 1555 (12 ottobre 2010): 3101–12. http://dx.doi.org/10.1098/rstb.2010.0145.
Testo completoAbstract (sommario):
Phenology affects nearly all aspects of ecology and evolution. Virtually all biological phenomena—from individual physiology to interspecific relationships to global nutrient fluxes—have annual cycles and are influenced by the timing of abiotic events. Recent years have seen a surge of interest in this topic, as an increasing number of studies document phenological responses to climate change. Much recent research has addressed the genetic controls on phenology, modelling techniques and ecosystem-level and evolutionary consequences of phenological change. To date, however, these efforts have tended to proceed independently. Here, we bring together some of these disparate lines of inquiry to clarify vocabulary, facilitate comparisons among habitat types and promote the integration of ideas and methodologies across different disciplines and scales. We discuss the relationship between phenology and life history, the distinction between organismal- and population-level perspectives on phenology and the influence of phenology on evolutionary processes, communities and ecosystems. Future work should focus on linking ecological and physiological aspects of phenology, understanding the demographic effects of phenological change and explicitly accounting for seasonality and phenology in forecasts of ecological and evolutionary responses to climate change.
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Gong, Ningping, e Björn Thrandur Björnsson. "Leptin Signaling in the Rainbow Trout Central Nervous System Is Modulated by a Truncated Leptin Receptor Isoform". Endocrinology 155, n. 7 (1 luglio 2014): 2445–55. http://dx.doi.org/10.1210/en.2013-2131.
Testo completoAbstract (sommario):
Central leptin (Lep) signaling is important in control of appetite and energy balance in mammals, but information on Lep signaling and physiological roles in early vertebrates is still lacking. To elucidate fish Lep signaling activation and modulation, a long-form Lep receptor (LepRL) and a truncated LepR (LepRT) are functionally characterized from rainbow trout. The receptors generated in alternatively splicing events have identical extracellular and transmembrane domains but differ in the intracellular sequence, both in length and identity. Gene transfection experiments show that LepRL is expressed as a 125-kDa protein in rainbow trout hepatoma cell line RTH-149, whereas LepRT is 100 kDa; both receptors specifically bind Lep. Homogenous Lep induces tyrosine phosphorylation of Janus kinase 2 and signal transducer and activation of transcription 3 in LepRL-expressing RTH-149 cells. This response is diminished in cells coexpressing LepRL and LepRT, suggesting that the LepRT which lacks these kinase-associated motifs competes with the LepRL for Lep availability, thus attenuating the Lep signal. Both receptor genes are highly expressed in the central nervous system. The mRNA levels of LepRT in hypothalamus, but not LepRL, change postprandially, with decreased transcription at 2 hours postfeeding and then elevated at 8 hours, concomitant with changes in proopiomelanocortin-A1 transcription. However, both receptors have no change in mRNA levels during 3 weeks of fasting. These data indicate that LepRT transcription is more likely a mechanism for modulating Lep effects on short-term feed intake than in regulating energy balance in the long term. In vitro and physiological characterization of LepR isoforms indicates divergent Lep signaling modulation patterns among vertebrates with different life histories and metabolic profiles.
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Dada, Oluwagbenga, Vincenzo De Luca, Ali Bani-Fatemi e Vincenzo De Luca. "S14. ANALYSIS OF METHYLATION AGE AND BLOOD CELL COMPOSITION IN SUBJECTS WITH CURRENT SUICIDE IDEATION". Schizophrenia Bulletin 46, Supplement_1 (aprile 2020): S36. http://dx.doi.org/10.1093/schbul/sbaa031.080.
Testo completoAbstract (sommario):
Abstract Background Suicidal Ideation (SI) remain an important and common risk factor affecting people with SCZ, who eventually attempt or complete suicide. Then the question is, what if factors (such as stressful life events and related molecular biomarkers) known to be involved in the aetiology of SCZ could help in predicting SI in this population? The accelerated aging hypothesis of SCZ posits that physiological changes associated with normal aging occur at an earlier age in individuals with SCZ than in the general population. Importantly, epigenetic changes may constitute an important component of aging process. Based on this, the chronological age can be predicted by the epigenetic clock in a highly consistent manner. The aims of this research were to determine the effect chronological and biological age on current SI and secondly, to determine the effect of the variation of cellular blood cell composition on current SI. Methods A total of 103 participants with a DSM-IV diagnosis of schizophrenia spectrum and other psychotic disorders were recruited from the Center of Addiction and Mental Health. The SI was assessed by the Columbia-Suicide Severity Rating Scale. Genome-wide DNA methylation analysis was generated from whole blood cells. The DNA methylation was assessed using the Illumina Infinium HumanMethylation450 Bead Chip while the DNA methylation-based age prediction and white blood cell composition were performed using the statistical pipeline developed by Horvath. Results Out of 103 participants, 18 had current SI (17%) while 85 had NSI. The DNAm age correlated with chronological age in the overall sample (r=0.814, p<0.0001), NSI (r=0.823, p<0.0001) and SI subjects (r=0.734, p=0.001). The strong linear relationship between DNAm age and chronological age showed a high accuracy of the epigenetic clock. However, DNAm age acceleration residuals did not differ between NSI and SI groups (t=1.532, p= 0.129). Comparison of the cellular cell blood composition between the NSI and SI groups indicated no significant differences between the NSI and SI groups (lymphocytes (t= -0.338, p=0.736), monocytes (t=-1.405, p=0.163) and granulocytes (t=0.924, p=0.358)). Furthermore, there were no significant differences between the SI and NSI groups in the analysis of the plasmablast (t=0.138, p=0.890), CD4 naïve (t=0.010, p=0.992) and CD8 naïve (t=0.681, p=0.497) Discussion Stressful life events may change DNA methylation, which in turn can affect suicide ideation and suicidal behavior. Although SCZ is associated with age-related physiological factors, we were unable to find accelerated aging in our study. Nevertheless, we cannot rule out the possibility of other aging mechanism independent of epigenetic aging in SCZ patients. Conclusion: Further studies aimed at investigating the accelerated aging hypothesis in peripheral tissue are warranted to identify individuals with SCZ at risk for suicide. This will permit a tailored treatment and will prevent suicide in SCZ individuals.
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Huang, Yu-Hsien, Amanda Rose Brown, Seres J. B. Cross, Jesus Cruz, Amber Rice, Stuti Jaiswal e Ralph F. Fregosi. "Influence of prenatal nicotine exposure on development of the ventilatory response to hypoxia and hypercapnia in neonatal rats". Journal of Applied Physiology 109, n. 1 (luglio 2010): 149–58. http://dx.doi.org/10.1152/japplphysiol.01036.2009.
Testo completoAbstract (sommario):
In a recent study (Huang YH et al. Respir Physiol Neurobiol 143: 1–8, 2004), we showed that prenatal nicotine exposure (PNE) increased the frequency of spontaneous apneic events on the first 2 days of life in unanesthetized neonatal rats. Here we test the hypothesis that PNE blunts chemoreceptor reflexes. Ventilatory responses to three levels each of hypoxia (inspired O2 fraction: 16, 12, and 10%) and hypercapnia (3, 6, and 9% inspired CO2 fraction, all in 50% O2, balance N2), and one level each of combined hypoxia-hypercapnia (H/H; 12% inspired O2 fraction/5% inspired CO2 fraction) and hyperoxia (50% O2, 50% N2) were recorded with head-out plethysmography in neonatal rats exposed to either nicotine ( N = 12) or physiological saline ( N = 12) in the prenatal period. Recordings were made on postnatal day 1 (P1), P3, P6, P9, P12, and P18, in each animal. The change in ventilation in response to hypoxia was blunted in PNE animals on P1 and P3, but there were no other treatment effects. Hyperoxia significantly depressed ventilation in both groups from P3–P18, but there were no significant treatment effects. The ventilatory response to 3, 6, and 9% inspired CO2 was significantly blunted in PNE animals at all ages studied, due exclusively to a blunted tidal volume response. PNE also blunted the ventilatory response to H/H at all ages, due primarily to blunting of the tidal volume response. PNE had no significant effect on body mass or metabolic rate, except that PNE animals had a slightly higher mass on P18 and a lower metabolic rate on P1. As shown by others, PNE has small and inconsistent effects on hypoxic ventilatory responses, but here we show that responses to hypercapnia and H/H are consistently blunted by PNE due to a diminished tidal volume response. The combination of reduced hypoxic and hypercapnic sensitivity over the first 3 days of life may define an especially vulnerable developmental period.
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Canovas, Sebastian, Raquel Romar e Pilar Coy. "207 Female Reproductive Fluids and Epigenetics". Journal of Animal Science 99, Supplement_1 (1 maggio 2021): 114. http://dx.doi.org/10.1093/jas/skab054.188.
Testo completoAbstract (sommario):
Abstract Physiological fertilization, and early embryo development, involves dramatic transcriptomic, epigenetic and morphological changes in a short temporal window. During this period gametes and early embryos are surrounded by reproductive fluids (oviductal and uterine), which contain nutrients, growth factors, hormones and extracellular vesicles acting as carriers of DNA, RNA, proteins and other factors with putative roles in intercellular communication. Under in vitro conditions, and in the absence of these fluids, embryos derived from Assisted Reproductive Technologies (ART) reveal transcriptional and epigenetic differences compared with in vivo embryos, which could result in long-term phenotypic consequences in adult life. Therefore, reproductive fluids supplementation in the culture medium offers an alternative to imitate physiological conditions and decrease these consequences. In vitro, oviductal fluid (OF) can modulate capacitation-associated events and sperm-zona pellucida interactions and contribute to the control of polyspermy in pigs. The use of in vitro fertilization media supplemented with reproductive fluids (Natur-IVF) improves embryo quality and blastocysts hatching ability. Moreover, Natur-IVF embryos show expression and methylation patterns closer to in vivo blastocysts. In cows, supplementation of culture media with reproductive fluids, or some isolated factors, improves blastocyst rate and survival after embryo transfer, and reverses the expression of some altered genes. However, considering the complexity of the oviductal and uterine fluids, it seems difficult that the use of just a few factors in isolation can reverse all undesired consequences of the IVP. On the other hand, sex-specific embryonic plasticity, as a consequence of the oviductal regulatory signals, have been proposed. Thus, we have analysed the sex-specific effect of supplementation with reproductive fluids in bovine embryos and data reveal sex-dependent impact in DNA methylation. All these results confirm that developmental programme can be modulated by reproductive fluids and it shows sex-specific effects. This strategy allows the possibility of minimizing undesired in vitro derived consequences.
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Hunt, Penelope J., Eleanor M. Gurnell, Felicia A. Huppert, Christine Richards, A. Toby Prevost, John A. H. Wass, Joseph Herbert e V. Krishna K. Chatterjee. "Improvement in Mood and Fatigue after Dehydroepiandrosterone Replacement in Addison’s Disease in a Randomized, Double Blind Trial". Journal of Clinical Endocrinology & Metabolism 85, n. 12 (1 dicembre 2000): 4650–56. http://dx.doi.org/10.1210/jcem.85.12.7022.
Testo completoAbstract (sommario):
Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are adrenal precursors of steroid biosynthesis and centrally acting neurosteroids. Glucocorticoid and mineralocorticoid deficiencies in Addison’s disease require life-long hormone replacement, but the associated failure of DHEA synthesis is not corrected. We conducted a randomized, double blind study in which 39 patients with Addison’s disease received either 50 mg oral DHEA daily for 12 weeks, followed by a 4-week washout period, then 12 weeks of placebo, or vice versa. After DHEA treatment, levels of DHEAS andΔ 4-androstenedione rose from subnormal to within the adult physiological range. Total testosterone increased from subnormal to low normal with a fall in serum sex hormone-binding globulin in females, but with no change in either parameter in males. In both sexes, psychological assessment showed significant enhancement of self-esteem with a tendency for improved overall well-being. Mood and fatigue also improved significantly, with benefit being evident in the evenings. No effects on cognitive or sexual function, body composition, lipids, or bone mineral density were observed. Our results indicate that DHEA replacement corrects this steroid deficiency effectively and improves some aspects of psychological function. Beneficial effects in males, independent of circulating testosterone levels, suggest that it may act directly on the central nervous system rather than by augmenting peripheral androgen biosynthesis. These positive effects, in the absence of significant adverse events, suggest a role for DHEA replacement therapy in the treatment of Addison’s disease.
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Garuglieri, Elisa, Jenny Marie Booth, Marco Fusi, Xinyuan Yang, Ramona Marasco, Tumeka Mbobo, Emanuela Clementi, Luciano Sacchi e Daniele Daffonchio. "Morphological characteristics and abundance of prokaryotes associated with gills in mangrove brachyuran crabs living along a tidal gradient". PLOS ONE 17, n. 4 (14 aprile 2022): e0266977. http://dx.doi.org/10.1371/journal.pone.0266977.
Testo completoAbstract (sommario):
Due to the chemico-physical differences between air and water, the transition from aquatic life to the land poses several challenges for animal evolution, necessitating morphological, physiological and behavioural adaptations. Microbial symbiosis is known to have played an important role in eukaryote evolution, favouring host adaptation under changing environmental conditions. We selected mangrove brachyuran crabs as a model group to investigate the prokaryotes associated with the gill of crabs dwelling at different tidal levels (subtidal, intertidal and supratidal). In these animals, the gill undergoes a high selective pressure, finely regulating multiple physiological functions during both animal submersion under and emersion from the periodical tidal events. We hypothesize that similarly to other marine animals, the gills of tidal crabs are consistently colonized by prokaryotes that may quantitatively change along the environmental gradient driven by the tides. Using electron microscopy techniques, we found a thick layer of prokaryotes over the gill surfaces of all of 12 crab species from the mangrove forests of Saudi Arabia, Kenya and South Africa. We consistently observed two distinct morphotypes (rod- and spherical-shaped), positioned horizontally and/or perpendicularly to the gill surface. The presence of replicating cells indicated that the prokaryote layer is actively growing on the gill surface. Quantitative analysis of scanning electron microscopy images and the quantification of the bacterial 16S rRNA gene by qPCR revealed a higher specific abundance of prokaryote cells per gill surface area in the subtidal species than those living in the supratidal zone. Our results revealed a correlation between prokaryote colonization of the gill surfaces and the host lifestyle. This finding indicates a possible role of prokaryote partnership within the crab gills, with potential effects on animal adaptation to different levels of the intertidal gradient present in the mangrove ecosystem.
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Netherer, Sigrid, Dineshkumar Kandasamy, Anna Jirosová, Blanka Kalinová, Martin Schebeck e Fredrik Schlyter. "Interactions among Norway spruce, the bark beetle Ips typographus and its fungal symbionts in times of drought". Journal of Pest Science 94, n. 3 (22 febbraio 2021): 591–614. http://dx.doi.org/10.1007/s10340-021-01341-y.
Testo completoAbstract (sommario):
AbstractResilience and functionality of European Norway spruce forests are increasingly threatened by mass outbreaks of the bark beetle Ips typographus promoted by heat, wind throw and drought. Here, we review current knowledge on Norway spruce and I. typographus interactions from the perspective of drought-stressed trees, host selection, colonisation behaviour of beetles, with multi-level effects of symbiotic ophiostomatoid fungi. By including chemo-ecological, molecular and behavioural perspectives, we provide a comprehensive picture on this complex, multitrophic system in the light of climate change. Trees invest carbon into specialised metabolism to produce defence compounds against biotic invaders; processes that are strongly affected by physiological stress such as drought. Spruce bark contains numerous terpenoid and phenolic substances, which are important for bark beetle aggregation and attack success. Abiotic stressors such as increased temperatures and drought affect composition, amounts and emission rates of volatile compounds. Thus, drought events may influence olfactory responses of I. typographus, and further the pheromone communication enabling mass attack. In addition, I. typographus is associated with numerous ophiostomatoid fungal symbionts with multiple effects on beetle life history. Symbiotic fungi degrade spruce toxins, help to exhaust tree defences, produce beetle semiochemicals, and possibly provide nutrition. As the various fungal associates have different temperature optima, they can influence the performance of I. typographus differently under changing environmental conditions. Finally, we discuss why effects of drought on tree-killing by bark beetles are still poorly understood and provide an outlook on future research on this eruptive species using both, field and laboratory experiments.
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Zhou, Mo, Rui Li, Yi Chen, Yan Gao, Yuhao Wei, Meishan Lu, Jieren Xi, Zhizhou Lin, Xiaoyun Zheng e Hong Jiang. "Impact of resistance exercise rehabilitation and whey protein supplementation in elderly patients with heart failure with preserved ejection fraction with sarcopenia: a study protocol for a randomised controlled trial". BMJ Open 12, n. 12 (dicembre 2022): e066331. http://dx.doi.org/10.1136/bmjopen-2022-066331.
Testo completoAbstract (sommario):
IntroductionHeart failure with preserved ejection fraction (HFpEF) affects more than half of the patients with heart failure. HFpEF and sarcopenia can interact with each other and contribute to reduced physiological function and increased mortality in elderly patients. Resistance training (RT) or resistance exercise rehabilitation (RER) may have benefits for elderly HFpEF patients with sarcopenia. Whey protein supplementation (WPS) may increase the effects of exercise on strength and muscle mass, in addition to promoting heart function and quality of life (QoL). However, studies are needed to evaluate effects of RER and WPS in patients with HFpEF with sarcopenia.Methods and analysisThis is a prospective, randomised, controlled clinical trial in which patients with HFpEF with sarcopenia will be randomly allocated to three groups, control, RT and RT+WP. Participants in all groups will receive basic intervention including standard medicine treatment, home-based aerobic exercise and basic nutritional intervention. The RT group will undergo resistance exercise programmes, and the RT+WP group will receive daily WPS apart from resistance exercise. The study variables will be evaluated at baseline and 12 weeks. Primary outcome measure is the change of 6 min walking distance. Secondary outcomes include parameters of muscle status, cardiac function, nutritional status, QoL and major adverse cardiovascular events. The primary efficacy analysis will follow the intention-to-treat principle.Ethics and disseminationThis study was approved by Ethics Committee of China-Japan Friendship Hospital for Clinical Research (No. 2022-KY-003). The results of this study will be disseminated via peer-reviewed publications and presentations at conferences.Trial registration numberChiCTR2200061069.
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Yakushevskaya, O. V. "Continuous combined low-dose hormone replacement therapy in perimenopause: an algorithm of choice". Meditsinskiy sovet = Medical Council, n. 3 (15 aprile 2021): 113–18. http://dx.doi.org/10.21518/2079-701x-2021-3-113-118.
Testo completoAbstract (sommario):
In the age of broad medical options, women’s health has received sufficient attention. The different periods of a woman’s life are characterised by specific physiological changes, based on the age-related characteristics of the reproductive system. The onset of menopause can have a negative impact on health in varying degrees. Clinicians have a clear understanding of the effects of estrogen deficiency and the therapeutic options for managing it with menopausal hormone therapy (MHT) and alternative methods of treatment. However, to date, methods for optimising and individualising the correction of menopausal disorders continue to improve. The individualization of MHT is aimed at increasing the efficacy of menopausal management and minimizing possible adverse events. Individualization is based on the selection of a hormone drug taking into account age, menopausal status, somatic health of the woman and her main complaints against the background of estrogen deficiency. The next stage of transformation of MHT concerned the composition of the drugs and the doses of their components. The evolution of the estrogenic component began with the use of conjugated estrogens, whose metabolism is not fully clarified, and stopped at the production of bioidentical estrogens (17p-estradiol and estradiol valerate), which in their structure are as close as possible to ovarian estradiol. The type, dose and combination of estrogens and progestogens determine the severity and specificity of the effect of the hormone. This article will present a clinical case study of the low- and ultra-low-dose combination of 17p-estradiol and dydrogesterone (E/DG).
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Nadholta, Pooja. "Efficacy of Yoga on pregnancy outcome, J Altern Complement Med. 2005 Apr;11(2):237-44". Integrative Medicine Case Reports 1, n. 1 (2020): 37. http://dx.doi.org/10.38205/imcr.010137.
Testo completoAbstract (sommario):
Pregnancy is a unique and challenging state, both physically and mentally. This requires mental, physical and social adaptation. Pregnancy related complications like pregnancy induced hypertension, preeclampsia, physiological and psychological stress, impaired placentation directly affect the fetal growth and also health of the neonate. It is already shown by animal experimentation that pregnancy outcomes are directly affected by prenatal maternal stress and it results in early programming of various organ systems that permanently changes neuroendocrine regulation and behavior in offspring. Various life events, illness, divorce, financial and social problems are some of the common stressor during pregnancy that activates hypothalamus-pituitary-adrenal cortex system (HPA axis) and sympathetic nervous system-adrenal medulla system (stress regulation system). Physical alteration, hormonal changes and anxiety are common during pregnancy period and these worsen the stress response. Already various attempts have been made to reduce pregnancy related stress. A study demonstrated that Yoga can be an effective therapy in reducing the pregnancy related complications and improving fetal outcomes. Satyapriya et al.showed that Yoga reduces anxiety, depression and pregnancy related uncomfortable experiences . Meditations inhibit the HPA axis that is activated during stress and calms the mind. Yoga is used to promote positive health and it uses holistic approach to reduce the stress. Integrated approach of Yoga therapy (IAYT) helps in reducing stress by practicing different postures (asanas), slow controlled breathing (Pranayama), Meditation and Chanting. This study tests the effect of IAYT on pregnancy related complications, stress and pregnancy outcome.
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Provenza, Frederick D., Juan J. Villalba, Carl D. Cheney e Scott J. Werner. "Self-organization of foraging behaviour: From simplicity to complexity without goals". Nutrition Research Reviews 11, n. 2 (dicembre 1998): 199–222. http://dx.doi.org/10.1079/nrr19980015.
Testo completoAbstract (sommario):
AbstractA herbivore faces challenges while foraging—ongoing changes in its physiological condition along with variation in the nutrient and toxin concentrations of foods, spatially and temporally—that make selecting a nutritious diet a vital affair. Foraging behaviours arise from simple rules that operate across levels of resolution from cells and organs to individuals and their interactions with social and physical environments. At all these levels, behaviour is a function of its consequences: a behaviour operating on the environment to induce changes is itself changed by those events. Thus, behaviour emerges from its own functioning—behaviour self-organizes-not from that of its surroundings. This ostensible autonomy notwith-standing, no self-organizing system (cell, organ, or individual) is independent of its environs because existence consists of an ongoing exchange of energy and matter. According to this view, the notion of cause and effect is replaced with functional relationships between behaviours and environmental consequences. Changes in physical environments alter the distribution, abundance, nutritional, and toxicological characteristics of plants, which affect food preference. Social interactions early in life influence behaviour in various ways: animals prefer familiar foods and environments, and they prefer to be with companions. Animals in unfamiliar environments often walk farther, ingest less food, and suffer more from malnutrition and toxicity than animals in familiar environments. An individual's food preferences—and its ability to discriminate familiar from novel foods—arise from the functional integration of sensory (smell, taste, texture) and postingestive (effects of nutrients and toxins on chemo-, osmo-, and mechano-receptors) effects. The ability to discriminate among foods is critical for survival: all problems with poisonous plants are due to an inability to discriminate or a lack of alternatives. Animals eat a variety of foods as a result of nearing or exceeding tolerance limits for sensory and postingestive effects unique to each food. After eating any food too frequently or excessively, the likelihood increases that animals will eat alternative foods owing to exceeding sensory-, nutrient-, and toxin-specific tolerance limits. Cyclic patterns of intake of a variety of foods reflect seemingly chaotic interactions among flavours, nutrients, and toxins interacting along continua.
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Valdes, Yirina, Nicole Viaene, Vivian Blok, Juan E. Palomares-Rius e Maurice Moens. "Changes in the pre-parasitic developmental stage of Globodera rostochiensis in response to green manures". Nematology 14, n. 8 (2012): 925–32. http://dx.doi.org/10.1163/156854112x635869.
Testo completoAbstract (sommario):
The sequence of events during the pre-parasitic and parasitic stages of the life cycle of Globodera rostochiensis, starting from hatching until host invasion and infection, is of major importance. Many of the physiological changes are initiated in the pre-parasitic stage in response to the influences exerted by the root diffusates of the host plant. The objectives of this study were to investigate whether root diffusates and extracts of green manures from Brassicaceae, in particular yellow mustard, fodder radish and rapeseed, have a direct effect on the pre-parasitic stage of G. rostochiensis. Unhatched second-stage juveniles (J2) were exposed to root diffusates and extracts from roots or above-ground parts of the green manures to assess: i) changes in eggshell permeability; ii) changes in diameter of the dorsal gland nucleolus; and iii) the activation of transcription in the dorsal and subventral pharyngeal glands. The 24 h exposure of unhatched J2 to the green manures did not indicate an alteration in eggshell permeability. The diameter of the dorsal gland nucleolus increased significantly after exposure to diffusates but not to extracts of the green manures, although the size in that case still did not exceed the measurements in J2 exposed to tomato root diffusates. The expression of the gene IVg9 in the dorsal gland was not detected after any treatment. However, transcriptional activation in the subventral pharyngeal glands was observed. Although the maximum expression of the cellulase gene was found in J2 exposed to tomato root diffusates, the expression in J2 exposed to root extracts of green manures was higher than in J2 exposed to root diffusates and extracts of above-ground plant parts. The potential of the investigated brassicaceous green manures to influence the pre-parasitic stage of G. rostochiensis is discussed.
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Leiva, Félix P., Piero Calosi e Wilco C. E. P. Verberk. "Scaling of thermal tolerance with body mass and genome size in ectotherms: a comparison between water- and air-breathers". Philosophical Transactions of the Royal Society B: Biological Sciences 374, n. 1778 (17 giugno 2019): 20190035. http://dx.doi.org/10.1098/rstb.2019.0035.
Testo completoAbstract (sommario):
Global warming appears to favour smaller-bodied organisms, but whether larger species are also more vulnerable to thermal extremes, as suggested for past mass-extinction events, is still an open question. Here, we tested whether interspecific differences in thermal tolerance (heat and cold) of ectotherm organisms are linked to differences in their body mass and genome size (as a proxy for cell size). Since the vulnerability of larger, aquatic taxa to warming has been attributed to the oxygen limitation hypothesis, we also assessed how body mass and genome size modulate thermal tolerance in species with contrasting breathing modes, habitats and life stages. A database with the upper (CTmax) and lower (CTmin) critical thermal limits and their methodological aspects was assembled comprising more than 500 species of ectotherms. Our results demonstrate that thermal tolerance in ectotherms is dependent on body mass and genome size and these relationships became especially evident in prolonged experimental trials where energy efficiency gains importance. During long-term trials, CTmax was impaired in larger-bodied water-breathers, consistent with a role for oxygen limitation. Variation in CTmin was mostly explained by the combined effects of body mass and genome size and it was enhanced in larger-celled, air-breathing species during long-term trials, consistent with a role for depolarization of cell membranes. Our results also highlight the importance of accounting for phylogeny and exposure duration. Especially when considering long-term trials, the observed effects on thermal limits are more in line with the warming-induced reduction in body mass observed during long-term rearing experiments. This article is part of the theme issue ‘Physiological diversity, biodiversity patterns and global climate change: testing key hypotheses involving temperature and oxygen’.
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Grekhoff, R. "FRI0621-HPR CHANGES IN LOCUS OF CONTROL LEVEL IN PATIENTS WITH RHEUMATOID ARTHRITIS AFTER THE COURSE OF BIOFEEDBACK TRAINING". Annals of the Rheumatic Diseases 79, Suppl 1 (giugno 2020): 915.1–915. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1571.
Testo completoAbstract (sommario):
Background:Objectives:Our aim was to study the effect of biofeedback (BFB) training on the locus of control in patients suffering from rheumatoid arthritis (RA), and to justify the use of this method in the complex treatment of the disease.Methods:40 RA patients hospitalized in the rheumatology department were examined. The average age of patients was 48. 6 years ± 7.73 years (from 30 to 70 years), women accounted for the majority = 26 (86%), the average duration of the disease was 12 years ± 3.44 years. We use J. Rotter’s Locus of Control Scale in E.F.Bazhin adaptation. RA patients were divided into two groups: the main (20 patients) and control (20 patients). Patients of the main group received complex therapy with 12 sessions of BFB training, mainly based on the parameters of the brain’s electrical activity — EEG relaxation using the Reakor™ psychophysiological rehabilitation complex manufactured by Medicom MTD (Taganrog).Results:We revealed externality in RA patients in the general field (3.03 ± 0.3), as well as in the field of relation to the disease (3.86 ± 0.23) and in the field of production relations (3.43 ± 0, 25). After BFB trainings, an increase in internality was observed on the scales of the general sphere (p <0.05) and attitude to the disease (p <0.01) in patients of the main group. In the group of patients receiving conventional treatment, the dynamics of the results was unreliable.Conclusion:It should be noted that the locus of control (or subjective control) is a quality that characterizes a person’s tendency to attribute responsibility for the results of his activity to external forces, or to his own abilities and efforts. Externality is manifested when people prefer to shift responsibility for important events of their life to external circumstances, and external forces (bosses, colleagues, etc.). In the field of attitude to the disease, externality is manifested when patient behaves passively, and believes that he cannot influence the course of the disease in any way, shifting all responsibility for the treatment results to medical staff, which can lead to non-compliance with the treatment regimen and an increase in the level of anxiety and depression, decreased self-esteem. The onset of the disease and its associated social consequences (disability, loss of social roles, etc.) can cause a negative mental state of learned helplessness. Learned helplessness is defined as a condition that occurs as a result of uncontrolled, mainly negative events, which manifests itself in violations of emotional, motivational and cognitive processes. In other words, RA patient suffering from this condition expects treatment failures and reduces control over compliance with the treatment regimen. BFB therapy can be used in order to correct and prevent the state of learned helplessness by increasing the level of internality.It is assumed that increasing internality in the BFB process is associated with teaching the patient the skills of self-regulation of physiological processes. The mechanisms of BFB therapeutic effect are not only changes in physiological parameters (improvement of cerebral and peripheral blood flow, muscle relaxation, and improvement of sleep) but also in a shift in the locus of control from external to internal, which can increase compliance, reduce neurotic complaints, mobilize volitional potential and improve patient self-esteem.As a result of BFB course, an increase in the internality was noted in patients on the scales of the general sphere and the sphere of attitude to the disease. It is advisable to use the BFB to increase the compliance and effectiveness of complex treatment of RA patients.Disclosure of Interests:None declared
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Li, Xiaofeng, Yun Lu e Xiantao Cheng. "STUDY ON THE EFFECT OF MINDFULNESS COGNITIVE BEHAVIOR THERAPY IN THE TREATMENT OF ANXIETY DISORDER -- BASED ON THE PERSPECTIVE OF INDIVIDUAL REHABILITATION". International Journal of Neuropsychopharmacology 25, Supplement_1 (1 luglio 2022): A108—A109. http://dx.doi.org/10.1093/ijnp/pyac032.146.
Testo completoAbstract (sommario):
Abstract Background Among many psychotherapy, beck cognitive therapy was once regarded as a classic therapy for mood disorders and anxiety neurosis. A. T. Beck believes that people's emotional and behavioral problems are related to individual distorted cognition, and abnormal cognition produces abnormal emotion and behavior. A large number of “Automatic negative thinking” In the minds of patients with depression is the root cause of mood disorders such as depression and anxiety. Finding and correcting these unreasonable cognitive patterns is the key to treatment. However, from the perspective of effect feedback, people have some disputes about beck cognitive therapy. Many scholars rely too much on the changing effect of cognitive model, have strong “Psychological aggression”, and are prone to great resistance. With the continuous development of psychological counseling and treatment technology, the new generation of cognitive therapy not only aims at the narrow cognitive process, but also pays more attention to the connection between situation and symptoms, and uses experiential change strategies to supplement direct cognitive preaching strategies, in order to establish a more flexible and broader technical path. Mindfulness cognitive behavioral therapy (mbct), as a representative of the new generation of cognitive behavioral therapy, has achieved remarkable results in the treatment of anxiety and depression, obsessive-compulsive disorder, somatization disorder and chronic pain. Its technical methods are worthy of application and promotion. Important includes six key treatment processes: (1) acceptance: Help the client establish a positive and defenseless attitude, embrace various experiences, and encourage the client not to avoid his / her past experiences. (2) cognitive deconfusion. Cognitive de integration, also known as cognitive dissociation, is to let visitors “Step back” To observe their various ideas, open the distance between them and various ideas, do not fall into the wave of ideas, and let patients try to treat them as psychological events rather than self or accurate inevitable response to reality, so as to achieve the purpose of adjusting thinking, imagination and memory functions. (3) self as context: Change the visitors' understanding of “Self-concept”, and let the visitors realize that the self-concept or self-concept network / system in their mind is not a true reflection of their real self through corresponding metaphor practice and psychological education, so as to liberate the visitors from their “Mind”. (4) being present: Encourage visitors to focus on the current situation and what is happening, rather than focusing on the past and future in their minds, or immersing themselves in various concepts and semantic relationships in their minds. Let visitors learn to feel the real life in a non evaluative way. (5) clarify values: Encourage visitors to find a life direction that is valuable and meaningful to visitors in their own life and professional fields. (6) committed action: Help visitors implement their values into specific short-term, medium-term and long-term goals. Based on the perspective of case rehabilitation, this study investigated the effect of mindfulness cognitive behavior therapy on the counseling and rehabilitation of diffuse anxiety disorder. Subjects and methods In this study, 30 college students diagnosed with diffuse anxiety disorder in a university were selected as the research object. There were three selection criteria: 1. The subjects were clearly diagnosed as anxiety disorder or in an anxiety state by the professional institution, and 2. The effect of the patients was not ideal after taking drugs for more than 3 months. 3. Anxiety disorder accompanied by depression. The randomized experimental group and the control group were used in the study. There were 16 subjects in the experimental group and 14 in the control group. The experimental group participated in mindfulness cognitive behavior training for 8 weeks, 2 days a week, once a day, a total of 16 times. The control group did not carry out any intervention. One week before the study, the organizer carried out short-term training for the experimental group, and then implemented phased treatment experience as planned to complete: “Live in the present”, “Perceive the body”, “Walk in the present”, “Emotion and body”, “Mindfulness perceive the feelings”, “Smart life, future life” And other mindfulness themes. During the training, encourage patients to communicate their physical feelings and questions. At the same time, the relevant scale is used for state detection. It mainly includes: Self rating anxiety scale (sas), self rating depression scale (sds) and related physiological indexes. To better control the impact of training on anxiety, this study arranged pre-test and post-test in the examination week as an external stressor. However, according to the two results of the two groups before and after the test, the paired sample test within the group and the independent sample test between the groups were carried out respectively. In the inter group difference test, in order to exclude the influence of the initial state, we first conduct an independent sample test on the baseline value of the variable, and then conduct an independent sample test on the difference obtained by subtracting the pre-test score from the post-test score. Results The results showed that in the intra group comparison, the scores of the experimental group and the post test were lower than those of the pre test, and the difference was significant, but there was no significant difference in the control group; in the comparison between groups, the reduction of post test scores in the experimental group was higher than that in the control group, and the difference between the two groups was significant. The above results show that mindfulness training has a positive effect on improving diffuse anxiety and accompanying depression, and the maintenance effect is good. It is generally believed that the realization principle of this function is to improve the ability of emotion management by increasing the current emotional experience and maintaining a neutral and objective attitude, and acquire the skills to get rid of negative thinking and feeling, so as to improve acceptance and reduce empirical avoidance behavior. In exploring the impact of mindfulness cognitive behavior therapy on physiological indicators, the study found that mindfulness cognitive behavior therapy can reduce muscle tension through the regulation of consciousness, improve the efficacy of physiological indicators such as electromyography, skin electricity, heart rate and respiration, activate and amplify positive emotional experience, and alleviate negative emotions such as tension, anxiety and depression. Life in a more peaceful and relaxed state. Affected by this state, the individual's evaluation of external stimuli may weaken the negative degree and enhance the positive degree. Therefore, negative emotions decrease and positive emotions increase. He no longer regards anxiety and depression as his enemy. He can coexist with it instead of living timidly for fear of its recurrence. Conclusion It can be used as an effective therapy to effectively regulate the anxiety of college students with anxiety disorder. It can improve individual negative emotional experience such as anxiety and depression, reduce individual muscle tension, reduce skin electricity, heart rate and respiratory rate, and improve brain wave level, which is helpful to alleviate tension and pressure. In conclusion, mindfulness cognitive behavioral therapy plays an obvious role in the treatment of anxiety neurosis and depression, and can be popularized in public patients. Acknowledgement This paper is supported by Teaching Research Project of Wuchang Shouyi University titled “Evaluation model and training method of innovation ability of robot professionals under OBE mode” with Grant No. 2021Y02 and Doctoral Research Start-Up Fund of Wuchang Shouyi University in 2022.
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Bashkina, O. A., M. A. Samotrueva, A. K. Azhikova e L. R. Paknnova. "NEUROIMMUNOENDOCRINE REGULATION OF THE SKIN FUNCTIONING". Medical Immunology (Russia) 21, n. 5 (13 dicembre 2019): 807–20. http://dx.doi.org/10.15789/1563-0625-2019-5-807-820.
Testo completoAbstract (sommario):
The review deals with modern ideas of neuroimmunoendocrine regulation of physiological and pathophysiological processes in skin. The present data are provided which indicate to composite mechanisms of intercellular interactions in complex regulating systems (nervous, immune, endocrine) acting at the level of skin in normal conditions, as well during the posttraumatic period. We describe different modes for participation of endocrine and nervous systems in immunologically induced skin inflammation. The data are provided confirming localization of adrenergic receptors on membranes of immunocompetent cells and leukocytes, on regulatory effects of hypothalamus upon immune functions, about multidirectional actions upon inflammation of sympathetic and parasympathetic nervous system etc.There are sufficient data on promotion of pathophysiological changes and reconstitution processes in the skin due to effects of local immune cells and bioactive substances expressed by them. The course of skin wound regeneration depend on the type of damage, degree and a phase of healing process. Posttraumatic reparative potential of skin is often limited by the infectious processes initiated by local microflora, products of cell disintegration and necrotic tissues. The cause-effect relationship is proven by arising inflammation which is implemented by inclusion of immune protection responses. The increased necrotic area and suppuration of the wound occurs die to inhibition of system of the phagocytizing macrophages. However, activation of this system brings about formation of the connective tissue capsule around the inflammation focus within early terms.We also discuss the issues of reparative skin regeneration which of great medico-social value, in connection with considerable prevalence of traumatic events and their social consequences, followed by expressed cosmetic defects. Evolving neurocognitive problems lead to decreased quality of the patient’s life, development of social disadaptation and further deprivation. The role of nervous system and psychological frustration in genesis of skin manifestations requires future development of the modern scientific direction, i.e., psychodermatology.Understanding of molecular mechanisms regulating the neuroimmunocutaneous interactions offers new prospectives in treatment of some skin diseases, as well as activation of the damaged skin recovery. According to the data presented in the review article, one may conclude on relevance of further studies on reparative potential of skin under interactions of homeostatic regulatory systems.
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Bessonov, Alexey A., e Alexandra A. Gaivoronskaya. "Priming and Its Effects in Obtaining Forensically Relevant Information". Vestnik Tomskogo gosudarstvennogo universiteta, n. 466 (2021): 207–12. http://dx.doi.org/10.17223/15617793/466/25.
Testo completoAbstract (sommario):
The article deals with the phenomenon of priming, its effects in obtaining and evaluating the testimony of interrogated persons in criminal cases. The problem of obtaining evidence is central to the criminal process and is considered as a system of actions of participants in the preliminary investigation related to the knowledge and modeling of past events, forecasting the investigation process in the future and obtaining evidentiary and orienting information. The analysis of the studied materials of criminal cases on 1,300 crimes against life and health, sexual integrity and sexual freedom of the individual showed that, in the structure of evidence, the testimony of witnesses, victims, accused persons (suspects) occupies more than a half (54.7%). An important role in obtaining and evaluating the testimony of persons questioned in a criminal case is played by priming, which promotes the activation of behavioral and trace manifestations of human memory in order to reproduce complete and objective forensically significant information in the testimony. The object of the study was the activity of the interrogator and the interrogated person video recorded during the criminal proceedings in the situation of interrogation. The empirical basis of the study was materials of more than 250 criminal cases (murders, rapes, crimes against property, etc.), of which more than 302 video materials of interrogations were viewed. When the interrogated person is ready to give evidence, but for some reason (physiological, psychological) cannot do it, the use of priming effects will help to change this situation in a favorable direction. In conflict situations of interrogation, the use of priming effects helps to correct the unconscious manifestations of psychological defenses, reduce the manifestations of psychological trauma, and establish psychological contact. The analysis of the content of information at an unconscious level, the search for features and categories (comparison with memory standards) is associated with the detection of this information in the space (array) of implicit memory; at the same time, the criteria for such a selection are determined by long-term memory that preserves standards, motivational attitudes and ways of processing input information. Local effects of unconscious information are reflected in conscious cognitive activity, especially in the study of investigative situations. The use of such tactics contributes to the investigation of crimes. The potential for using priming effects in conducting investigative actions aimed at obtaining the testimony of participants in the pretrial stage of criminal proceedings (witnesses, victims, suspects, accused persons) expands the possibilities for obtaining information. The tactic of using priming in the investigation of criminal acts requires a deeper scientific study and experimental confirmation.
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KENDLER, KENNETH S., JONATHAN W. KUHN e CAROL A. PRESCOTT. "Childhood sexual abuse, stressful life events and risk for major depression in women". Psychological Medicine 34, n. 8 (novembre 2004): 1475–82. http://dx.doi.org/10.1017/s003329170400265x.
Testo completoAbstract (sommario):
Background. In animals, early trauma can produce long-lasting changes in sensitivity to the pathogenic effects of stress. To explore whether similar processes occur in humans, we examine whether childhood sexual abuse (CSA) in women alters sensitivity in adulthood to the depressogenic effects of stressful life events (SLEs).Method. A history of CSA was obtained from a population-based sample of 1404 female adult twins. Cox Proportional hazard models were used to predict onsets of episodes of DSM-III-R major depression (MD) in the past year from previously assessed levels of neuroticism (N), CSA and past-year SLEs scored on long-term contextual threat.Results. In the best-fit model, onset of MD was predicted by CSA, SLEs and N. Individuals with CSA (and especially with severe CSA) had both an overall increased risk for MD and a substantially increased sensitivity to the depressogenic effects of SLEs. A ‘dose–response’ relationship between severity of CSA and sensitivity to SLEs was clearer in those with low to average levels of N than in those with high levels of N.Conclusion. As documented with physiological responses to a standardized laboratory stressor, CSA increases stress sensitivity in women in a more naturalistic setting. Both genetic and early environmental risk factors can produce long-term increase in the sensitivity of individuals to depressogenic life experiences.
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Wiley, John W. "III. Senescent enteric nervous system: lessons from extraintestinal sites and nonmammalian species". American Journal of Physiology-Gastrointestinal and Liver Physiology 283, n. 5 (1 novembre 2002): G1020—G1026. http://dx.doi.org/10.1152/ajpgi.00224.2002.
Testo completoAbstract (sommario):
Functional changes in GI motility associated with advanced age include slowing of gastric emptying, decreased peristalsis, and slowing of colonic transit. These changes appear to be associated with region-specific loss of neurons and impaired function. The mechanism(s) underlying physiological aging are likely to be multifactorial. Alterations in specific signal transduction pathways have been reported at the level of the receptor and postreceptor events including kinase expression and function, mitochondrial function, and activation of the apoptosis cascade. Advanced age is associated with increased oxidative stress and its concomitant effects on cellular function. Whereas no specific genes have been causally linked to life span in mammals, studies involving nonmammalian species suggest that specific genes are involved in determining life span and age-related changes in cellular function. Caloric restriction is the only intervention shown to slow aging in a variety of species. Recent studies implicate a possible role for an insulin/IGF-I cascade in the region- and tissue-specific changes associated with physiological aging.
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Grimm, Kevin, e Katerina Marcoulides. "Individual change and the timing and onset of important life events". International Journal of Behavioral Development 40, n. 1 (16 aprile 2015): 87–96. http://dx.doi.org/10.1177/0165025415580806.
Testo completoAbstract (sommario):
Researchers are often interested in studying how the timing of a specific event affects concurrent and future development. When faced with such research questions there are multiple statistical models to consider and those models are the focus of this paper as well as their theoretical underpinnings and assumptions regarding the nature of the effect of the event on the developmental process. We discuss three models, all variants of growth models specified within the multilevel modeling framework, which conceptualize the developmental process and the effect of the event in different ways. These models include the growth model with a time-invariant covariate, the growth model with a time-varying covariate, and the spline growth model. After discussing the models in detail, we applied these models to longitudinal data from the Berkeley Growth Study to examine cognitive changes during infancy and the effect of independent sitting on those changes. Results suggest that research conclusions depend on the model chosen and how certain results can be misconstrued unless the model accurately reflects the research questions. Recommendations and additional non-traditional models are discussed.
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Sharabi, Moshe, Oriana Abboud Armaly e Ola AbuHasan-Nabwani. "The Effect of Major Life Events on Individual's Work Centrality: Social and Economic Aspects". Review of European Studies 13, n. 4 (22 novembre 2021): 46. http://dx.doi.org/10.5539/res.v13n4p46.
Testo completoAbstract (sommario):
This unique study compares the change in work centrality among individuals (n=407) both those who did experience and those who did not experience major life events, over the course of twelve years. The data was collected via the “Meaning of Work” questionnaire that included questions on work and life events. Special analysis of life events allows us to examine the causal nature of the relationship between life events and work centrality. The findings indicated that childbirth had an opposite effect on men's and women's work centrality. The work centrality of individuals who experienced divorce, a worsening of financial conditions and taking a considerable loan, did not change, while it increased among those who did not experience these events. There are several suggestions for the social and welfare and policymakers regarding life events, and the impact these policies may have on the magnitude of these events on work centrality.
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Bondar, Natalya P., Arina A. Lepeshko e Vasiliy V. Reshetnikov. "Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice: Sex-Specific Effects". Behavioural Neurology 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/1538931.
Testo completoAbstract (sommario):
Stressful events in an early postnatal period have critical implications for the individual’s life and can increase later risk for psychiatric disorders. The aim of this study was to investigate the influence of early-life stress on the social behavior of adult male and female mice. C57Bl/6 mice were exposed to maternal separation (MS, 3 h once a day) or handling (HD, 15 min once a day) on postnatal day 2 through 14. Adult male and female mice were tested for social behavior in the social interaction test and for individual behavior in the plus-maze and open-field tests. Female mice exposed to maternal separation had increased social behavior and increased anxiety. MS male mice had no changes in social behavior but had significantly disrupted individual behavior, including locomotor and exploratory activity. Handling had positive effects on social behavior in males and females and decreased anxiety in males. Our results support the hypothesis that brief separation of pups from their mothers (handling), which can be considered as moderate stress, may result in future positive changes in behavior. Maternal separation has deleterious effects on individual behavior and significant sex-specific effects on social behavior.
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Riese, Harriëtte, Harold Snieder, Bertus F. Jeronimus, Tellervo Korhonen, Richard J. Rose, Jaakko Kaprio e Johan Ormel. "Timing of Stressful Life Events Affects Stability and Change of Neuroticism". European Journal of Personality 28, n. 2 (marzo 2014): 193–200. http://dx.doi.org/10.1002/per.1929.
Testo completoAbstract (sommario):
Neuroticism is a predictor of many health problems. To study the determinants of within–subject change in neuroticism, three hypotheses were tested: (i) subjects who experienced stressful life events (SLEs) show an increase in neuroticism; (ii) high baseline neuroticism moderated this effect; and (iii) recent SLEs had a greater impact on neuroticism than distant SLEs. Data came from the Finnish Twin Cohort. Neuroticism data were collected in 1975 and 1981 and SLEs data in 1981 (n = 21 085). By entering baseline neuroticism as a predictor for neuroticism at follow–up, the outcome measure was change in neuroticism. Changes in neuroticism were predicted from SLE indices or their interaction with baseline neuroticism. Timing of SLEs was taken into account by distinguishing recent from distant SLEs. To control for confounding by shared genes and environments, both within–twin pair and between–twin pair effects were tested for monozygotic and dizygotic twin pairs separately. Neuroticism's six–year stability was high (r = .58, p < .001). Exposure to SLEs modestly increased neuroticism (βs > .55, ps < .001), unconfounded by shared genes. This effect was not moderated by high baseline neuroticism. Recent SLEs (.09 < βs < .15) had more impact than distant SLEs (.03 < βs < .11; ps < .01). In conclusion, the findings strongly supported a model of environmentally driven SLEs causing dynamic fluctuations around a person's set point of neuroticism. Copyright © 2013 John Wiley & Sons, Ltd.
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Thomas, SA, E. Friedmann, F. Wimbush e E. Schron. "Psychological factors and survival in the cardiac arrhythmia suppression trial (CAST): a reexamination". American Journal of Critical Care 6, n. 2 (1 marzo 1997): 116–26. http://dx.doi.org/10.4037/ajcc1997.6.2.116.
Testo completoAbstract (sommario):
BACKGROUND: Evaluating the independent effects of psychosocial and physiological factors on survival of cardiac patients is difficult because it requires obtaining extensive physiological and psychosocial data and long-term follow-up of high-risk patients. OBJECTIVES: To examine the independent contributions of psychosocial and physiological status to survival of patients who had had myocardial infarction. METHODS: The sample consisted of 348 patients in the Cardiac Arrhythmia Suppression Trial who had asymptomatic ventricular arrhythmias after myocardial infarction. Psychosocial status was assessed with the Social Support Questionnaire-6, Social Readjustment Rating Scale, State-Trait Anxiety Inventory, Self-Rating Depression Scale, Jenkins Activity Survey, and Expression of Anger Scale. Physiological data included measurement of left ventricular ejection fraction; history of previous myocardial infarction, congestive heart failure, and diabetes; and results of Holter monitoring. RESULTS: At the first follow-up, after the effect of the physiological predictors was controlled for, psychosocial factors were significant independent predictors of survival. Among men in the nonactive medication group (n = 263), higher state anxiety, lower anger outward, more past life events, and lower expectations of future life events were predictors of mortality. Data suggested that the relationship of anger to mortality might differ for men and women. Increases in past life events and depression from baseline to first follow-up were greater among those who died than among those who lived. CONCLUSION: Among patients who had asymptomatic ventricular arrhythmias after myocardial infarction, psychological status during the period after infarction contributed to mortality beyond the effect of physiological status. The results reaffirm the critical interrelationship between mind and body for cardiovascular health.
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Jackson, Joshua J., e Emorie D. Beck. "Personality Development Beyond the Mean: Do Life Events Shape Personality Variability, Structure, and Ipsative Continuity?" Journals of Gerontology: Series B 76, n. 1 (16 luglio 2020): 20–30. http://dx.doi.org/10.1093/geronb/gbaa093.
Testo completoAbstract (sommario):
Abstract Objectives Life experiences are thought to prompt changes in personality. However, existing studies find few replicable mean-level changes in personality following life events. The focus on mean-level change may obscure other types of personality change that are not routinely studied in the context of life events. These are variability in response, structural, and ipsative change. Methods The current proposal examines whether major life events (e.g., divorce and job loss) affect these 3 understudied types of personality trait change using 3 waves of Big Five trait data in a large-scale, representative longitudinal study (German Socioeconomic Panel Study, N = 16,368). Structural equation models compare those who had an event to their prior self and a control group who did not experience the event. Results Life events were found to have mostly null or small effects on variability in response, structural, and ipsative change. Across 2 types of tests for variability in response, few replications occurred. The only consistent effect across 3 types of change was for mental health events, which served to increase variance in all Big Five traits and increase consistency in ipsative profiles. Discussion Life events tend not to affect these novel metrics of personality trait change. The one exception of mental health events is consistent with previous literature on mean-level change. Overall, life events do not appear to by major catalysts of personality change, regardless of how change is defined.
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Morley, Catherine. "Development and Use of The Organizational Framework For Exploring Nutrition Narratives". Critical Dietetics 3, n. 2 (31 dicembre 2016): 32–42. http://dx.doi.org/10.32920/cd.v3i2.1008.
Testo completoAbstract (sommario):
A hermeneutic phenomenology was undertaken to explore eating and feeding experiences with 11 women living with changed health status and who had household feeding responsibilities. Thematic analysis yielded two distinct narratives; those in Life-the-Same (LS) group (n=3; participants whose lives were relatively the same after a period of adjustment), and the Life Altered (LA) group (n=8) (those whose lives were completely altered as a result of their condition). Participants in the LS group had adjusted to new dietary, exercise, and medication routines, achieved physiologic goals, and retained eating and feeding routines at and away from home. Participants in the LA group experienced profound changes in ingesting and digesting food, and eliminating waste, physical appearance, and in enjoyment of eating, and rarely left home. Anticipated physiologic effects of dietary change were not achieved due to physical deterioration. Family and friends took on feeding duties when the regular ‘feeder’ was acutely ill, however, participants resumed these roles as soon as they were able (even though they remained unwell) owing to the strength of role identification. The Organizational Framework for Exploring Nutrition Narratives (OFFENN) emerged from the analysis, and is comprised of four domains (Personal; Household; Beyond Household; and Unthoughts), and four filters (Events/Facts; Values/Beliefs; Actions; Emotions and Reflections). The framework offers a means to explore clients’ narratives and to invite conversations about eating and feeding; it is not meant to be prescriptive of dietary guidance, and has application in dietetics education (in preparing students for their counselling roles and in informing research).
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Yang, Hyun-Jeong, Eugene Koh, Min-Kyu Sung e Hojung Kang. "Changes Induced by Mind–Body Intervention Including Epigenetic Marks and Its Effects on Diabetes". International Journal of Molecular Sciences 22, n. 3 (28 gennaio 2021): 1317. http://dx.doi.org/10.3390/ijms22031317.
Testo completoAbstract (sommario):
Studies have evidenced that epigenetic marks associated with type 2 diabetes (T2D) can be inherited from parents or acquired through fetal and early-life events, as well as through lifelong environments or lifestyles, which can increase the risk of diabetes in adulthood. However, epigenetic modifications are reversible, and can be altered through proper intervention, thus mitigating the risk factors of T2D. Mind–body intervention (MBI) refers to interventions like meditation, yoga, and qigong, which deal with both physical and mental well-being. MBI not only induces psychological changes, such as alleviation of depression, anxiety, and stress, but also physiological changes like parasympathetic activation, lower cortisol secretion, reduced inflammation, and aging rate delay, which are all risk factors for T2D. Notably, MBI has been reported to reduce blood glucose in patients with T2D. Herein, based on recent findings, we review the effects of MBI on diabetes and the mechanisms involved, including epigenetic modifications.
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Larouche, Richard, Ulises Charles Rodriguez, Ransimala Nayakarathna e David R. Scott. "Effect of Major Life Events on Travel Behaviours: A Scoping Review". Sustainability 12, n. 24 (12 dicembre 2020): 10392. http://dx.doi.org/10.3390/su122410392.
Testo completoAbstract (sommario):
The transportation sector accounts for about a quarter of global greenhouse gas emissions. Previous research suggests that major life events may be “windows of opportunity” for travel behaviour change. Our scoping review examined the effects of seven events (transitions to secondary school, post-secondary studies, labour market, marriage, parenthood, retirement, and relocation) on travel behaviours. Five databases were searched (MEDLINE, APA PsycINFO, Web of Science, SportDISCUS, and ProQuest Dissertations and Theses) and 80 articles met inclusion criteria. Relocation was the most commonly examined event (with 51 studies). Findings illustrate that moving to compact neighbourhoods (with shorter commute distance/travel time, greater walkability/access to destinations) was associated with shifts towards sustainable travel modes (e.g., walking, cycling, and transit). Relocation might be particularly conducive to implementing scalable sustainable transportation interventions, as all six interventions with appropriate statistical power were effective. Entry into the labour market was generally associated with increased car use and declines in sustainable transportation. Qualitative studies suggested that attitudes towards cycling may become negative during adolescence, while attitudes towards driving improve, highlighting a need for concerted action. Evidence for other events was less consistent. Research in developing countries remain scarce and further intervention research is needed to enhance quality of evidence.
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Corvite, Shanley, Ben Zefeng Zhang e Oliver L. Haimson. "Social Media's Role During Identity Changes Related to Major Life Events". Proceedings of the ACM on Human-Computer Interaction 6, CSCW2 (7 novembre 2022): 1–22. http://dx.doi.org/10.1145/3555219.
Testo completoAbstract (sommario):
Major life events can cause great upheaval in one's life. Many people perceive their identities to change due to major life events. During identity shifts, impression management and self-presentation, online communities, and social media affordances can allow individuals to better facilitate their experiences. To examine how people perceive their identity to change during major events and how they use social media in the process, we interviewed 28 participants who recently experienced major life events. We found that many people perceived their identity to change through various avenues that they felt were important to their identity: mental processes, identity roles, and identity fulfillment. However, some people perceive their identity to be maintained rather than changed. During identity changes or maintenance, participants utilized impression management and self-presentation to curate their online presence. Participants also used online communities to build relationships with similar others or virtual friends and enable more connections via what we call the domino effect. Social media sites also provided the affordances of editability, visibility control, and spreadability, which can help ease life transition and identity change processes.
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McEwen, B. "004.From molecules to mind: stress, allostasis and integration of brain and body". Reproduction, Fertility and Development 16, n. 9 (2004): 4. http://dx.doi.org/10.1071/srb04abs004.
Testo completoAbstract (sommario):
The mind involves the whole body and two-way communication between the brain and the cardiovascular, immune and other systems via neural and endocrine mechanisms. Stress is a condition of the mind and a factor in the expression of disease that differs among individuals. A broader view is that it is not just the dramatic stressful events that exact their toll but rather the many events of daily life that elevates activities of physiological systems so as to cause some measure of wear and tear. We call this wear and tear 'allostatic load', and it reflects not only the impact of life experiences but also genetic load' individual life-style habits reflecting items such as diet, exercise and substance abuse' and developmental experiences that set life-long patterns of behavior and physiological reactivity (1). Hormones associated with stress and allostatic load protect the body in the short-run and promote adaptation, but the long run allostatic load causes changes in the body that lead to disease. This will be illustrated for the immune system and brain regions involved in stress, fear and cognition (e.g. hippocampus, amygdala and prefrontal cortex). Besides developmental influences associated with mother–infant interactions, the most potent of stressors in adult life are those arising from competitive interactions between animals of the same species, leading to the formation of dominance hierarchies. Psychosocial stress of this type not only impairs cognitive function of lower ranking animals, but it can also promote disease (e.g. atherosclerosis) among those vying for the dominant position, as well as depressive illness. Social ordering in human society is also associated with gradients of disease, with an increasing frequency or mortality and morbidity as one descends the scale of socioeconomic status (SES) that reflects both income and education. Although the causes of these gradients of health are very complex, they are likely to reflect, with increasing frequency at the lower end of the scale, the cumulative burden of coping with limited resources and negative life events as well as differences in life style, and the allostatic load that this burden places on the physiological systems involved in adaptation and coping. (1) McEwen, B.S. (1998) Protective and damaging effects of stress mediators. New England J. Med. 238, 171–179.
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Wade, Mark, Margaret A. Sheridan, Charles H. Zeanah, Nathan A. Fox, Charles A. Nelson e Katie A. McLaughlin. "Environmental determinants of physiological reactivity to stress: The interacting effects of early life deprivation, caregiving quality, and stressful life events". Development and Psychopathology 32, n. 5 (dicembre 2020): 1732–42. http://dx.doi.org/10.1017/s0954579420001327.
Testo completoAbstract (sommario):
AbstractChildren who spend their early lives in institutions experience profound psychosocial deprivation that is associated with altered stress response system development. Here, we used data from a longitudinal randomized controlled trial of foster care for institutionally reared children to examine whether caregiving quality and stressful life events (SLEs) in early adolescence (age 12) influence patterns of hypothalamic–pituitary–adrenal (HPA) axis and sympathetic nervous system (SNS) reactivity. Controlling for the effect of institutional care, higher caregiving quality at age 12 was associated with heightened cortisol and SNS reactivity. However, moderation analysis revealed that the latter effect was only observed among never-institutionalized children, whereas ever-institutionalized children demonstrated a persistently blunted SNS response regardless of recent caregiving quality. Among institutionally reared children, SLEs interacted with prior random assignment to foster care, such that those placed in foster care early in development had a SNS response that approximated never-institutionalized children when SLEs at age 12 were low. In contrast, SNS reactivity was persistently blunted among those with prolonged deprivation, regardless of recent SLEs. Early-life deprivation is associated with persistent blunting of stress response systems, but normalization may be achievable if SLEs are limited following placement into enriched family-based care.
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Paluch, Amanda E., Robin P. Shook, Gregory A. Hand, Daniel P. O’Connor, Sara Wilcox, Clemens Drenowatz, Meghan Baruth, Stephanie Burgess e Steven N. Blair. "The Influence of Life Events and Psychological Stress on Objectively Measured Physical Activity: A 12-Month Longitudinal Study". Journal of Physical Activity and Health 15, n. 5 (1 maggio 2018): 374–82. http://dx.doi.org/10.1123/jpah.2017-0304.
Testo completoAbstract (sommario):
Background: This study examined how life event occurrences and stressfulness influence objectively measured light through vigorous physical activity (PA) among young adults. Methods: Every 3 months over a 12-month period, 404 healthy young adults completed questionnaires on the occurrence and stress of 16 life events and wore an accelerometer for 10 days. Results: A modest positive relationship was seen between cumulative life event occurrences [between effect: β = 22.2 (9.7) min/d, P = .02] and cumulative stress [between effect: β = 7.6 (2.9) min/d, P = .01] with light through vigorous PA among men. When considering events individually, job change, starting a first job, beginning a mortgage, and changes in a relationship influenced men’s PA. For women, mortgage, starting a first job, job change, and engagement had significant associations. Life event stressfulness influenced PA in women more than in men. For men, stress from changes in a relationship or job positively influenced PA. Stress of a mortgage, quitting a job, changing jobs or a first job influenced women’s PA. Conclusion: Considering each life event individually was more informative than the summation of life events or summation of stress. Specific life events substantially altered PA, and this change varied by gender, direction of association, and PA intensity and duration.
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Wolff, Julia K., Svenja M. Spuling, Ann-Kristin Beyer, Maja Wiest e Susanne Wurm. "DO SERIOUS HEALTH EVENTS CHANGE HOW WE VIEW OUR OWN AGING? ON THE ROLE OF CARDIOVASCULAR EVENTS". Innovation in Aging 3, Supplement_1 (novembre 2019): S787. http://dx.doi.org/10.1093/geroni/igz038.2897.
Testo completoAbstract (sommario):
Abstract Several studies have demonstrated beneficial effects of views on aging (VoA) on health, while the reverse relationship is seldom in focus. Serious health events (e.g., myocardial infarction) are life-threatening and remind individuals of the finitude of life possibly changing their VoA. The present study investigates the effect of cardiovascular events (CVE) on longitudinal changes in VoA using pooled data of three waves of the German Ageing Survey (2008, 2011, 2014, age-range: 40-95 years). To account for alternative explanations, individuals without CVE were matched to the individuals with CVE (n = 202) using a propensity-score-matching approach. Individuals who experienced a CVE showed more adverse changes in three VoA indicators (aging associated with physical losses, ongoing development, felt age) than individuals without CVE. Results show that CVE can change how we view our own aging which in turn affects future health changes. Following a CVE people may benefit from promoting positive VoA.
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Rahman, Osmud, e Hong Yu. "Key antecedents to the shopping behaviours and preferences of aging consumers". Journal of Fashion Marketing and Management: An International Journal 23, n. 2 (13 maggio 2019): 193–208. http://dx.doi.org/10.1108/jfmm-12-2018-0165.
Testo completoAbstract (sommario):
Purpose The purpose of this paper is to gain a deeper understanding of how income, cognitive age, physiological change and life-changing events may affect older consumers’ shopping behaviours and preferences. Design/methodology/approach In-depth semi-structured interview was employed for this study. In total, 13 informants were recruited in Toronto, including 11 females and 2 males aged between 51 and 80 years. Content analysis and holistic interpretation were employed for data analysis. Findings According to the findings, price was a major concern to many informants regardless of their income level. The relationship between “feel age”, “look age”, or even “health age”, are not always positively correlated. The vast majority of the informants preferred shopping at the brick-and-mortar stores over online shopping. Some informants experienced difficulties or challenges in finding clothing that fit well due to the change of their body shapes. In addition, many informants needed to adjust their personal needs and buying priorities to cope with their changing personal situations and social roles. Practical implications Other than the price and mobility issues, older consumers encounter different challenges when they shop for different products. It is imperative for retailers, service providers and product developers to understand the older consumers’ changing needs, aspirations and challenges through diverse perspectives – the transition of social roles, physiological change and life-changing events. Originality/value Many prior studies are merely focused on one topic (e.g. cognitive age) or product category (e.g. clothing). Through this multidimensional and mixed categorical approach, new knowledge and insights can be generated and added to the current body of research.
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Oduor, Loreto Atieno, Willis Owino, Elijah M. Ateka e Jane Ambuko. "Effect of Surface Coatings on the Shelf life and Quality of Cassava". Journal of Food Research 7, n. 1 (20 dicembre 2017): 46. http://dx.doi.org/10.5539/jfr.v7n1p46.
Testo completoAbstract (sommario):
Cassava (Manihot esculenta) is grown as an important dietary source of carbohydrates for communities in a number of African countries. However, Cassava is susceptible to postharvest physiological deterioration which affects its quality and leads to the unpalatability and unmarketability of roots after harvest. Edible surface coatings have been found to be effective in preserving the quality of various perishable food products. This study was undertaken with the objective of determining the best combinations and concentrations of both xanthan gum and guar gum capable as a technology for extending the shelf life of harvested cassava roots. Cassava (variety KME 1) was harvested at physiological maturity. The coating formulations used were: 1%, 1.5%, 2% guar gum, 1.5%, 2%, 2.5% xanthan gum, and 1%, 1.5%, and 2.5% xanthan guar/gum combination in the ratio of 1:1 with some roots left as control. Sampling was done at 2-day intervals for 20 days. The coated cassava showed lower respiration and ethylene production rates than the control samples while change in quality parameters; phenols, colour, flesh firmness, weight loss and dry matter content was significantly (P≤0.05) delayed in the coated samples. The results suggested that using 1.5% xanthan guar/gum as an edible coating, cassava shelf life can be extended by upto 20 days at 25 °C.
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KESSING, L. V., E. AGERBO e P. B. MORTENSEN. "Does the impact of major stressful life events on the risk of developing depression change throughout life?" Psychological Medicine 33, n. 7 (25 settembre 2003): 1177–84. http://dx.doi.org/10.1017/s0033291703007852.
Testo completoAbstract (sommario):
Background. It is unclear whether there is an interaction of ageing on the association between major life events and onset of depression.Method. This was a population-based nested case–control study with linkage of the Danish Psychiatric Central Research Register and the Integrated Database for Longitudinal Labour Market Research. The study includes data on all admissions at psychiatric wards in Denmark from 1981 to 1998 and data on sociodemographic variables and death/suicide of first-degree relatives.Results. A total of 13006 patients who received a diagnosis of depression at the first ever admission at a psychiatric ward and a gender- and age-matched control group of 260108 subjects were identified. A recent divorce and recent unemployment and suicide of a relative (mother, father, sibling, child, spouse) were associated with increased risk of being admitted for the first time ever at a psychiatric ward with a diagnosis of depression whereas death of a relative by causes other than suicide years had no significant effect. In general, no interaction was found with age with any of the variables, totally, or for men or women, separately.Conclusions. The susceptibility to major life stressors does not seem to change throughout life.
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Wingfield, John C., Jonathan H. Pérez, Jesse S. Krause, Karen R. Word, Paulina L. González-Gómez, Simeon Lisovski e Helen E. Chmura. "How birds cope physiologically and behaviourally with extreme climatic events". Philosophical Transactions of the Royal Society B: Biological Sciences 372, n. 1723 (8 maggio 2017): 20160140. http://dx.doi.org/10.1098/rstb.2016.0140.
Testo completoAbstract (sommario):
As global climate change progresses, the occurrence of potentially disruptive climatic events such as storms are increasing in frequency, duration and intensity resulting in higher mortality and reduced reproductive success. What constitutes an extreme climatic event? First we point out that extreme climatic events in biological contexts can occur in any environment. Focusing on field and laboratory data on wild birds we propose a mechanistic approach to defining and investigating what extreme climatic events are and how animals cope with them at physiological and behavioural levels. The life cycle of birds is made up of life-history stages such as migration, breeding and moult that evolved to match a range of environmental conditions an individual might expect during the year. When environmental conditions deteriorate and deviate from the expected range then the individual must trigger coping mechanisms (emergency life-history stage) that will disrupt the temporal progression of life-history stages, but enhance survival. Using the framework of allostasis, we argue that an extreme climatic event in biological contexts can be defined as when the cumulative resources available to an individual are exceeded by the sum of its energetic costs—a state called allostatic overload. This allostatic overload triggers the emergency life-history stage that temporarily allows the individual to cease regular activities in an attempt to survive extreme conditions. We propose that glucocorticoid hormones play a major role in orchestrating coping mechanisms and are critical for enduring extreme climatic events. This article is part of the themed issue ‘Behavioural, ecological and evolutionary responses to extreme climatic events’.