Bibliografie tematiche / Lemon Hill (Philadelphia, Pa.)

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Letteratura scientifica selezionata sul tema "Lemon Hill (Philadelphia, Pa.)"

Autore: Grafiati

Pubblicato: 29 luglio 2024

Ultima modifica: 31 luglio 2024

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Articoli di riviste sul tema "Lemon Hill (Philadelphia, Pa.)"

Ice, Gillian H. "Proceedings of the Human Biology Association 32nd Annual Meeting, March 29, 2007, Sheraton Society Hill, Philadelphia, PA". American Journal of Human Biology 20, n. 2 (2008): 242–48. http://dx.doi.org/10.1002/ajhb.20761.

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Ruiz, Victor M., Lindsay Hill, Manasa Gadde, Christopher Bulow, Maurizio Morri e Nicholas Goldner. "Abstract B030: Using the ResCu system for preclinical testing of KRAS G12C inhibitors". Molecular Cancer Research 21, n. 5_Supplement (1 maggio 2023): B030. http://dx.doi.org/10.1158/1557-3125.ras23-b030.

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Abstract Introduction: Recent colorectal cancer trials with KRAS G12C inhibitors have faced resistance challenges, and a preclinical model is needed to test resistance inhibition strategies. Experimental Methods: We have developed a novel culturing system, ResCu, that allows for long-term culture of cells without the need for passaging, enabling us to determine treatment resistance that can develop over time in a physiologically relevant system that conserves the resistance pathways found in patients. Using this system, we evolved resistance to a KRAS G12C inhibitor, sotorasib, after only two weeks of culture. The evolved cells were characterized for cross-resistance and cross-sensitivity by exposing these cells to a panel of drugs for seven days. Cell viability was assessed by luminescence. Based on the drug screen results, the sotorasib evolved cells were further evolved to additional drug classes to identify novel therapeutic combinations. Whole population and single-cell transcriptomic analysis were used to identify resistance mechanisms and synthetic lethality. Results: Using the ResCu system, we evolved resistance to sotorasib, a KRAS G12C inhibitor, and other drugs in combination with sotorasib. We identified a synergistic combination of sotorasib and a secondary inhibitor that initially suppressed resistance in the sotorasib evolved cells. We identified potential mechanisms underlying this synergy using transcriptomic analysis to enable future mechanistic characterization. Subsequently, the ResCu system drove resistance evolution to the sotarasib synergistic combination. We identified splicing alterations associated with this resistance. Conclusion: We have developed a novel resistance culturing system, ResCu, that allows for preclinical testing of KRAS G12C inhibitors and determines the most promising compounds for inhibiting specific resistance pathways. This system allows for long-term culturing of cells without passaging, thereby maintaining the various phenotypes of the original populations that are commonly lost in traditional passaging cultures. Citation Format: Victor M. Ruiz, Lindsay Hill, Manasa Gadde, Christopher Bulow, Maurizio Morri, Nicholas Goldner. Using the ResCu system for preclinical testing of KRAS G12C inhibitors [abstract]. In: Proceedings of the AACR Special Conference: Targeting RAS; 2023 Mar 5-8; Philadelphia, PA. Philadelphia (PA): AACR; Mol Cancer Res 2023;21(5_Suppl):Abstract nr B030.

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Anderson, Ashley, Tate Bertea, James Neiswender, Lisa Brenan, Megan Wong, Alina Simerzin, Sarah Wie et al. "Abstract B014: Charting ovarian cancer dependencies with patient-derived organoids". Cancer Research 84, n. 5_Supplement_2 (4 marzo 2024): B014. http://dx.doi.org/10.1158/1538-7445.ovarian23-b014.

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Abstract The Cancer Dependency Map aims to accelerate precision cancer medicine by identifying the landscape of cancer vulnerabilities across all tumors. To address underrepresented cancer types, we have optimized a genome-wide CRISPR KO screening pipeline, utilizing a condensed Cas12a library, for patient-derived 3D models. Here, we present characterization of a cohort of ovarian models which consist of underrepresented cancer subtypes along with treatment-resistant cancers. In particular, our organoid dataset includes low-grade serous carcinoma models, an ovarian cancer subtype that is understudied and not previously characterized in 2D DepMap screens. The increased representation of ovarian models will improve the potential of DepMap to uncover genetic drivers of ovarian cancers. Through genomic perturbation we showed that these 3D models achieved screen quality comparable to historically derived 2D models. Our methods provide a framework for screening future cancer models and discovering vulnerabilities in select patient populations. Citation Format: Ashley Anderson, Tate Bertea, James Neiswender, Lisa Brenan, Megan Wong, Alina Simerzin, Sarah Wie, Isabella Boyle, Lauren Golden, Barbara De Kegel, Josh Dempster, Yuen-Yi Tseng, David Root, Sarah Hill, Andrew Aguirre, Francisca Vazquez. Charting ovarian cancer dependencies with patient-derived organoids [abstract]. In: Proceedings of the AACR Special Conference on Ovarian Cancer; 2023 Oct 5-7; Boston, Massachusetts. Philadelphia (PA): AACR; Cancer Res 2024;84(5 Suppl_2):Abstract nr B014.

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Xiao, Weikun, Chae-Young Eun, Weian Zhao e Reginald Hill. "Abstract 5848: Identification of mechanosensitive cancer associated fibroblasts in pancreatic cancer". Cancer Research 83, n. 7_Supplement (4 aprile 2023): 5848. http://dx.doi.org/10.1158/1538-7445.am2023-5848.

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Abstract The purpose of this study is to investigate whether a subpopulation of cancer associated fibroblasts (CAFs) are responsible for mechanosensation-mediated chemoresistance in pancreatic adenocarcinoma (PDAC). PDAC is one of the most lethal types of cancer with few effective treatments. The abundant stromal cells and the stiff desmoplastic microenvironment constitute more than 90% of the primary tumor bulk. However, there are few easily tunable models to recapitulate this stiff microenvironment. To address this issue, we have developed a Matrigel-based, orthogonally tunable 3-dimensional (3D) culture system to co-culture mouse derived PDAC organoids and host-matching cancer-associated fibroblasts (CAFs). Using this biomimetic model and a mechano-sensation-dependent reporter, we have identified a unique subpopulation of CAFs responsible for mechano-sensing the fibrotic matrix and facilitating CAF-mediated chemoresistance. Moreover, these mechanosensitive CAFs (mecCAFs) respond to increased stiffness through YAP-mediated pathways. Our results also demonstrate how ECM stiffness affects chemoresistance via the hypersecretion CAF-derived exosomes. Moving forward, therapies designed to interrupt the function of mecCAFs could be utilized to overcome matrix-mediated chemoresistance in PDAC. Citation Format: Weikun Xiao, Chae-Young Eun, Weian Zhao, Reginald Hill. Identification of mechanosensitive cancer associated fibroblasts in pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5848.

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Oberholtzer, Nathaniel, Paramita Chakraborty, Mohamed Faisal Kassir, James Dressman, Zacharia Hedley, Gina Scurti, Monika Gooz et al. "Abstract LB343: Golgihi T cells exhibit reduced susceptibility to exhaustion and improved tumor control". Cancer Research 84, n. 7_Supplement (5 aprile 2024): LB343. http://dx.doi.org/10.1158/1538-7445.am2024-lb343.

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Abstract The role of tumor microenvironment mediated disruption of Golgi architecture and function,termed Golgi stress, in the regulation of T cell survival and function are largely unknown. Here weshow that the disruption of Golgi architecture, identified by the decreased expression of GM130,was reverted upon treatment with hydrogen sulfide (H2S) donor GYY4137, or over-expressingcystathionine β-synthase (Cbs), an enzyme involved in the biosynthesis of endogenous H2S -that promoted stemness, antioxidant capacity and exhibited increased protein translationmediated in part by ER-Golgi shuttling of Peroxiredoxin-4. In in vivo models of melanoma andlymphoma, anti-tumor T cells conditioned ex vivo with exogenous H2S or overexpressing Cbsdemonstrated superior tumor control upon adoptive transfer. Further, Golgihi T cells, with highGolgi content, exhibited unique metabolic and glycation signature with enhanced anti-tumorcapacity. These data suggest that strategies to mitigate Golgi network stress or using Golgihitumor-reactive T cells can improve tumor control upon adoptive transfer. Citation Format: Nathaniel Oberholtzer, Paramita Chakraborty, Mohamed Faisal Kassir, James Dressman, Zacharia Hedley, Gina Scurti, Monika Gooz, Lauren E. Ball, Elizabeth Hill, Anand S. Mehta, Eduardo N. Maldonado, Michael I. Nishimura, Besim Ogretmen, Shikhar Mehrotra. Golgihi T cells exhibit reduced susceptibility to exhaustion and improved tumor control [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB343.

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Tang, Fanying, Duo Xu, Shangqian Wang, Chen Khuan Wong, Alexander Martinez-Fundichely, Cindy Lee, Sandra Cohen et al. "Abstract B026: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets". Cancer Research 82, n. 23_Supplement_2 (1 dicembre 2022): B026. http://dx.doi.org/10.1158/1538-7445.cancepi22-b026.

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Abstract In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR) dependence leads to clinically aggressive tumors with few therapeutic options. We used ATAC-seq (assay for transposase-accessible chromatin sequencing), RNA-seq, and DNA sequencing to investigate 22 organoids, six patient-derived xenografts, and 12 cell lines. We identified the well-characterized AR-dependent and neuroendocrine subtypes, as well as two AR-negative/low groups: a Wnt-dependent subtype, and a stem cell–like (SCL) subtype driven by activator protein–1 (AP-1) transcription factors. We used transcriptomic signatures to classify 366 patients, which showed that SCL is the second most common subtype of CRPC after AR-dependent. Our data suggest that AP-1 interacts with the YAP/TAZ and TEAD proteins to maintain subtype-specific chromatin accessibility and transcriptomic landscapes in this group. Together, this molecular classification reveals drug targets and can potentially guide therapeutic decisions. Citation Format: Fanying Tang, Duo Xu, Shangqian Wang, Chen Khuan Wong, Alexander Martinez-Fundichely, Cindy Lee, Sandra Cohen, Jane Park, Corinne Hill, Kenneth Eng, Rohan Bareja, Teng Han, Eric Minwei Liu, Ann Palladino, Wei Di, Dong Gao, Wassim Abida, Shaham Beg, Loredana Puca, Maximiliano Meneses, Elisa De Stanchina, Michael Berger, Anuradha Gopalan, Lukas Dow, Juan Miguel Mosquera, Himisha Beltran, Cora Sternberg, Ping Chi, Howard Scher, Andrea Sboner, Yu Chen, Ekta Khurana. Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets [abstract]. In: Proceedings of the AACR Special Conference: Cancer Epigenomics; 2022 Oct 6-8; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2022;82(23 Suppl_2):Abstract nr B026.

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Hill, Breana, Ioana Bondre, H. Meryem Soylu, Juliette Antoine, Xiao Lei Chen, Elise Tahon, Yichi Zhang et al. "Abstract B024: Maintenance therapy inhibition of ptk2 yields decreased disease in preclinical HRP/HRD models of recurrent HGSOC". Cancer Research 84, n. 5_Supplement_2 (4 marzo 2024): B024. http://dx.doi.org/10.1158/1538-7445.ovarian23-b024.

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Abstract High grade serous ovarian cancer remains the most lethal of the gynecologic malignancies, in part, because of the high incidence of recalcitrant and rapidly recurring disease. Disease recurrence is now better controlled due to maintenance therapy with PARP inhibitors, particularly in homologous repair deficient tumors. Efficacy in homologous repair proficient tumors represents an unmet need. We previously demonstrated that inhibitors of protein tyrosine kinase 2 (ptk2), a gene that is frequently gained in HGSOC, compromises the expression of tumor repair genes, decreases stemness, and limits immune evasion. The low toxicity of ptk2 inhibitors appears to be well suited for a maintenance role. Here, we tested the effect of six weeks of ptk2 inhibitor maintenance treatment, post-chemotherapy, in two preclinical models. In a homologous repair proficient model (KMF), and in a PARP inhibitor-resistant model (HGS2), ptk2 inhibitor treatment yielded lower tumor burden, fewer solid tumors, and decreased bloody ascites accumulation relative to treatment with Niraparib. The low toxicity and overall efficacy provide strong support for future clinical trials with ptk2 inhibitors in the maintenance role, for patients with HGSOC. Citation Format: Breana Hill, Ioana Bondre, H Meryem Soylu, Juliette Antoine, Xiao Lei Chen, Elise Tahon, Yichi Zhang, Marjaana Olajill, Sarah Kinkel, Terrie-Anne Cock, Pratibha Binder, Chris Burns, David Schlaepfer, Michael McHale T. McHale, Dwayne G Stupack. Maintenance therapy inhibition of ptk2 yields decreased disease in preclinical HRP/HRD models of recurrent HGSOC [abstract]. In: Proceedings of the AACR Special Conference on Ovarian Cancer; 2023 Oct 5-7; Boston, Massachusetts. Philadelphia (PA): AACR; Cancer Res 2024;84(5 Suppl_2):Abstract nr B024.

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Hill, Katherine A., Cynthia M. Pérez, Adriana Pons, Karelys Canales Birriel, Andrea López Cepero, Norangelys Solís Torres, Zaydelis Tamarit Quevedo e Vivian Colón-López. "Abstract C130: Cervical, breast, and colorectal cancer screening by COVID-19 booster and influenza vaccination status in a sample of women in Puerto Rico". Cancer Epidemiology, Biomarkers & Prevention 32, n. 1_Supplement (1 gennaio 2023): C130. http://dx.doi.org/10.1158/1538-7755.disp22-c130.

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Abstract Background: Recommendation by a healthcare provider is essential for women to seek preventative cancer screening. Research has shown patients are receptive to information about cancer screening given by health professionals administering influenza vaccines. Promotion of cancer screening during vaccination may be particularly important in Puerto Rico (PR), which, relative to the continental United States, has low cervical and colorectal cancer screening rates. Objective: This study aims to determine if receiving the influenza vaccine in the past year or ever receiving the COVID-19 booster is associated with an increased likelihood of women participating in cervical, breast, and colorectal cancer screening in the past year. Methods: Women older than 18 are recruited weekly in different ongoing community outreach events throughout Puerto Rico as part of the Puerto Rico Community Engagement Alliance (PR-CEAL) against COVID-19 disparities. The PR-CEAL outreach team completes an online community survey as part of their field activities. Initial data was collected from February 17th 2022 through May 28th 2022, with data collection currently ongoing. Pearson χ2 test or Fisher exact test, as appropriate, was used to quantify the association between participation in cancer screening and vaccination status. Results: As of May 31st, 253 women with a median age of 59 had been recruited. Of these, 56.1% had received the influenza vaccine in the past year, and 52.6% had received a COVID-19 booster. Nearly 52% of women with the booster and 65% without the booster received cervical cancer screening (p-value = 0.29). Women with the booster and those without the booster (75% each) received breast cancer screening (p-value = 0.99). Only 16.1% of women with the booster and 11.8% without the booster had received colorectal cancer screening (p-value = 0.99). Receipt of cancer screening according to influenza vaccine status was as follows: 59.3% vaccinated and 51.5% unvaccinated received cervical cancer screening (p-value = 0.35); 31.4% vaccinated and 41.2% unvaccinated received breast cancer screening (p-value = 0.56); and 13.1% vaccinated and 9.3% unvaccinated received colorectal cancer screening (p-value = 0.46).Conclusions: No differences in receipt of cancer screening were found by influenza or COVID-19 booster vaccination status among adult women in Puerto Rico. Routine vaccination appointments may therefore represent a missed opportunity to promote cancer screening. Citation Format: Katherine A. Hill, Cynthia M. Pérez, Adriana Pons, Karelys Canales Birriel, Andrea López Cepero, Norangelys Solís Torres, Zaydelis Tamarit Quevedo, Vivian Colón-López. Cervical, breast, and colorectal cancer screening by COVID-19 booster and influenza vaccination status in a sample of women in Puerto Rico [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C130.

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Culp-Hill, Rachel, Collin Hill, Adele Blackler e William Ricketts. "Abstract 2447: Identification of tumor marker gangliosides for early cancer detection: A mass spectrometry approach". Cancer Research 84, n. 6_Supplement (22 marzo 2024): 2447. http://dx.doi.org/10.1158/1538-7445.am2024-2447.

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Abstract Tumor-marker gangliosides (TMGs) have enormous potential for early-stage cancer detection as diagnostic biomarkers despite being relatively understudied in this context. AOA Dx is focused on the development of a mass spectrometry platform for the quantitation of TMGs in human serum, particularly disialogangliosides GD2 and GD3. The development of a mass spectrometry platform for TMG quantitation may allow for the identification of diagnostic signatures for early-stage cancer detection. Briefly, we monitored fragment moieties characteristic of gangliosides in an untargeted fashion by mass spectrometry. We then identified those differentially altered in cancerous groups compared to normal, and subsequently performed targeted MRM analysis. Through these investigations, we have identified multiple TMGs, specifically multiple types of GD2 and GD3 species characterized by unique lipid tails across different cancer types in human serum from confirmed cancer diagnoses. Other ganglioside classes including GMs and relatively understudied GTs were also identified in this study. Notably, the serum of melanoma and ovarian cancer patients exhibited significantly increased levels of several ganglioside species compared to age-matched healthy serum, highlighting the potential of TMGs as a promising avenue for cancer diagnosis. Further experiments will focus on refining this mass spectrometry method and expand demographic representation to confirm our initial findings and identify additional TMGs of interest. In addition, we intend to apply immune-based platforms such as thin-layer chromatography and ELISA, which have already shown promising results in the detection and quantitation of these compounds. Taken together, AOA Dx is advancing the development of a high-throughput mass spectrometry platform designed for the detection of TMGs, with a primary focus on GD2 and GD3. Our objective is the identification of a diagnostic disease signature for early-stage cancer detection. The validation of this type of diagnostic panel would allow for expedited diagnosis and treatment of cancers currently diagnosed at late stages, ultimately reducing healthcare costs and increasing survival rates. Future research will aim to validate these biomarkers in independent prospective studies. Citation Format: Rachel Culp-Hill, Collin Hill, Adele Blackler, William Ricketts. Identification of tumor marker gangliosides for early cancer detection: A mass spectrometry approach [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2447.

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Brown, Edward, Danielle Desa, Robert M. Brown, Edward B. Brown, Robert L. Hill e Bradley M. Turner. "Abstract P5-06-13: Second-harmonic generation imaging reveals neoadjuvant chemotherapy-induced changes in breast tumor collagen". Cancer Research 82, n. 4_Supplement (15 febbraio 2022): P5–06–13—P5–06–13. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-06-13.

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Abstract Breast cancer is the most common invasive cancer in women, with most deaths attributed to metastases. Neoadjuvant chemotherapy (NACT) may be prescribed prior to surgical removal of the tumor for subsets of breast cancer patients but can have diverse undesired and off-target effects including increased appearance of the ‘tumor microenvironment of metastasis’ or TMEMs, image-based multicellular signatures which are prognostic of metastasis. In this study we explored whether NACT alters other image-based prognostic/predictive signatures, specifically second-harmonic generation (SHG) directionality, which is indicative of collagen fiber internal structure, as well as the disorganization in collagen fiber alignment. This was performed in paired biopsy/excision samples from 22 patients with HER2 overexpressing invasive ductal carcinoma as well as 22 patients with triple negative breast cancer (TNBC). We found that collagen fiber internal structure, measured using the SHG forward-to-backward-scattered ratio (F/B), is altered in the bulk of the tumor in both tumor types (p = 0.015 and 0.038, respectively), but not the adjacent tumor-stroma interface (p = 0.54 and 0.92, respectively), where F/B is prognostic of metastatic outcome. Overall disorganization in collagen fiber alignment was not significantly changed by NACT in HER2 overexpressing disease (p = 0.41) but was decreased in TNBC (p = 0.0051). These results suggest that NACT alters the collagenous extracellular matrix in diverse ways, with implications for the use of F/B and collagen fiber alignment as prognostic and predictive tools. Citation Format: Edward Brown, Danielle Desa, Robert M Brown, Edward B Brown, Robert L Hill, Bradley M Turner. Second-harmonic generation imaging reveals neoadjuvant chemotherapy-induced changes in breast tumor collagen [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P5-06-13.

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Tesi sul tema "Lemon Hill (Philadelphia, Pa.)"

Weiler, Emily A. "50 years after independence : preservation of places, spaces and memory". 2012. http://liblink.bsu.edu/uhtbin/catkey/1671231.

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This thesis will study three specific subjects in order to document changing viewpoints in American culture in relation to nationalism, patriotism, and memories from older generations. It will be studying a space- Bunker Hill, a place- Independence Hall and a person- Marquis Lafayette at approximately fifty years after the signing of the Declaration of Independence. Each subject will explore the ways the memory of the soldiers involved in the American Revolution have been preserved and remembered. It is the intent of this thesis to establish the importance of the passage of time especially when it comes to preserving historic artifacts and buildings and the way the changing associations have on how we preserve these artifacts.
The triumphal tour of Marquis Lafayette -- Independence Hall -- Bunker Hill Monument.
Department of Architecture

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Libri sul tema "Lemon Hill (Philadelphia, Pa.)"

Contosta, David R. A Philadelphia family: The Houstons and Woodwards of Chestnut Hill. Philadelphia: University of Pennsylvania Press, 1988.

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Contosta, David R. A parish journey, 1856-2006: St. Paul's Episcopal Church, Chestnut Hill, Philadelphia. [S.l: David R. Contosta, 2006.

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Contosta, David R. A parish journey, 1856-2006: St. Paul's Episcopal Church, Chestnut Hill, Philadelphia. [S.l: David R. Contosta, 2006.

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ill, Tibbles Jean-Paul, a cura di. Shadows on Society Hill: An Addy mystery. Middleton, WI: Pleasant, 2007.

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Umile, Eric M. City set on a hill: A history of Emmanuel United Methodist Church of Roxborough, 1888-1984. [Philadelphia?]: E.M. Umile, 1985.

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Jones, R. Bruce. The history of Green Street Monthly Meeting of Friends of Philadelphia, and of the meetings under its care at Fair Hill, Frankford, and Girard Avenue. Philadelphia: Green Street Monthly Meeting, 1988.

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Contosta, David R. A venture in faith: The Church of St. Martin-in-the-Fields, 1889-1989, Chestnut Hill/Philadelphia, Pennsylvania. [Philadelphia, Pa.]: The Church, 1988.

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Frederic, Schwartz, Scully Vincent Joseph 1920- e Venturi Robert, a cura di. Mother's house: The evolution of Vanna Venturi's house in Chestnut Hill. New York: Rizzoli, 1992.

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Heffner, John H. St. Michael's Lutheran Church, Germantown--Mt. Airy: Marriages, 1745-1795 ; St. John's Lutheran Church : Fourth and Sassafras, Philadelphia, established 1808 : burials. Topton, [Pa.]: J.H. Heffner, 1995.

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Heffner, John H. St. Michael's Lutheran Church, Germantown--Mt. Airy: Births, baptizms [sic], marriages, 1751 to 1845. Topton, [Pa.]: J.H. Heffner, 1995.

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