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Letteratura scientifica selezionata sul tema "Iron Metabolism"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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Articoli di riviste sul tema "Iron Metabolism"

1

Conway, Deirdre, and Mark A. Henderson. "Iron metabolism." Anaesthesia & Intensive Care Medicine 23, no. 2 (2022): 123–25. http://dx.doi.org/10.1016/j.mpaic.2021.10.021.

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COUGHLAN, MICHAEL P. "Iron Metabolism." Biochemical Society Transactions 13, no. 4 (1985): 803. http://dx.doi.org/10.1042/bst0130803.

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3

Aisen, Philip, Marianne Wessling-Resnick, and Elizabeth A. Leibold. "Iron metabolism." Current Opinion in Chemical Biology 3, no. 2 (1999): 200–206. http://dx.doi.org/10.1016/s1367-5931(99)80033-7.

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Conway, Deirdre, and Mark A. Henderson. "Iron metabolism." Anaesthesia & Intensive Care Medicine 20, no. 3 (2019): 175–77. http://dx.doi.org/10.1016/j.mpaic.2019.01.003.

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5

Badwing, TP. "Iron Metabolism." Biochemical Education 13, no. 3 (1985): 150. http://dx.doi.org/10.1016/0307-4412(85)90229-8.

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6

Ponka, Prem. "Cellular iron metabolism." Kidney International 55 (March 1999): S2—S11. http://dx.doi.org/10.1046/j.1523-1755.1999.055suppl.69002.x.

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7

Anderson, Gregory J., and David M. Frazer. "Hepatic Iron Metabolism." Seminars in Liver Disease 25, no. 04 (2005): 420–32. http://dx.doi.org/10.1055/s-2005-923314.

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Rouault, Tracey A., and Sharon Cooperman. "Brain Iron Metabolism." Seminars in Pediatric Neurology 13, no. 3 (2006): 142–48. http://dx.doi.org/10.1016/j.spen.2006.08.002.

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9

Valerio, Luis G. "Mammalian Iron Metabolism." Toxicology Mechanisms and Methods 17, no. 9 (2007): 497–517. http://dx.doi.org/10.1080/15376510701556690.

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Kohgo, Yutaka. "2. Iron Metabolism and Iron Overload." Nihon Naika Gakkai Zasshi 100, no. 9 (2011): 2412–24. http://dx.doi.org/10.2169/naika.100.2412.

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Tesi sul tema "Iron Metabolism"

1

SAITO, HIROSHI. "METABOLISM OF IRON STORES." Nagoya University School of Medicine, 2014. http://hdl.handle.net/2237/20543.

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2

Alvarez-Hernandez, J. "Iron metabolism in macrophages." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375442.

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3

Xue, Yue 1978. "Iron metabolism in mammalian cells." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79216.

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Iron, known for its versatility, is an essential element in the metabolism of mammalian cells. One of the most common iron disorders is autosomal recessive disease---hereditary hemochromatosis, which leads to the iron overload in population of northern European descent. During years of my graduate research, I focused on the study of Hemochromatosis gene Hfe and a point mutation C282Y that leads to more than 80% of all hemochromatosis cases.<br>Iron Regulatory Proteins (IRPs), which serve as main posttranscriptional regulators of cellular iron homeostasis, are the other interest of resea

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4

Whitnall, Megan. "Iron metabolism, chelation and disease." Thesis, The University of Sydney, 2011. https://hdl.handle.net/2123/28914.

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Organisms depend on iron to survive. This fact is underscored by the critical requirement for iron during DNA synthesis and as a cofactor in proteins involved in respiration and oxygen transport. However, when present in excess of cellular requirements, iron can be toxic, due to its ability to generate reactive oxygen species and induce oxidative stress. The physiological significance of iron renders it a target for the development of iron chelators as therapeutic agents and highlights the potential problems that can occur when iron regulatory pathways are disturbed in disease. The rapid rat

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5

Ekins, Andrew John. "Iron acquisition by Histophilus ovis." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38481.

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Five strains (9L, 642A, 714, 5688T and 3384Y) of Histophilus ovis were investigated with respect to iron acquisition. All strains used ovine, bovine and goat, but not porcine or human, transferrins (Tfs) as iron sources for growth. In solid phase binding assays, total membranes from only two (9L and 642A) of the five strains, grown under iron-restricted conditions, were able to bind Tfs (ovine, bovine and goat, but not porcine or human). However, when the organisms were grown under iron-restricted conditions in the presence of bovine Tf, total membranes from all strains exhibited Tf binding (a

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Sritharan, Manjula. "Studies in iron metabolism of mycobacteria." Thesis, University of Hull, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278446.

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Lopes, Tiago Jose da Silva. "Systems biology analysis of iron metabolism." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16417.

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Jede Zelle des Säugetierorganismus benötigt Eisen als Spurenelement für zahlreiche oxidativ-reduktive Elektronentransfer-Reaktionen und für Transport und Speicherung von Sauerstoff. Der Organismus unterhält daher ein komplexes Regulationsnetzwerk für die Aufnahme, Verteilung und Ausscheidung von Eisen. Die intrazelluläre Regulation in den verschiedenen Zelltypen des Körpers ist mit einer globalen hormonellen Signalstruktur verzahnt. Sowohl Eisenmangel wie Eisenüberschuss sind häufige und ernste menschliche Krankheitsbilder. Sie betreffen jede Zelle, aber auch den Organismus als Ganzes. In die

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Bahrami, Fariborz. "Iron acquisition in Actinobacillus suis." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85880.

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Seven strains of Actinobacillus suis (ATCC 15557, B49, C84, H89-1173, H91-0380, SO4 and VSB 3714) were investigated with respect to iron acquisition from animal transferrins (Tfs) and haemoglobins (Hbs). Growth assays with porcine, bovine and human Tfs and Hbs revealed that all seven strains could use porcine (but not human or bovine) Tf and all three Hbs as iron sources. In solid phase binding assays, membranes derived from all strains exhibited strong binding of porcine Tf and each of the Hbs. Competition binding assays indicated that all three Hbs were bound by the same receptor(s).

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Bae, Dong-Hun. "The Effects of Iron Levels on the Interaction between Polyamine Metabolism and Iron Metabolism in Neoplastic Cells." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18081.

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Iron is a crucial element that is associated with many metabolic pathways important for life sustaining processes. Polyamines are small positively charged polycations involved in various physiological functions. Both iron and polyamines levels are known to be high in cancer cells which suggests a possible unexplored link between the two metabolic pathways. For the first time, we demonstrate that iron-depletion robustly regulates the expression of 13 polyamine pathway proteins. Iron-depletion also decreased polyamine and S-adenosylmethionine levels (required for spermidine/spermine biosynthesi

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Tremblay, Yannick. "Acquisition of haemoglobin-bound iron by Histophilus somni." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82441.

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Abstract (sommario):

Ovine (strains 9L and 3384Y) and bovine (strains 649, 2336 and 8025) isolates of Histophilus somni were investigated for their ability to acquire iron from haemoglobin (Hb). Bovine isolates were capable of utilizing bovine, but not ovine, porcine or human Hb as a source of iron. Ovine isolates could not obtain iron from Hb. Bovine isolates bound bovine, ovine, and human Hbs by means of the same iron-repressible receptor(s) and produced a ~120-kDa iron-repressible, outer membrane protein. Using PCR approaches, an iron-regulated operon containing hugX and hugZ homologues and a gene (hgbA)

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Libri sul tema "Iron Metabolism"

1

Crichton, Robert. Iron Metabolism. John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781118925645.

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2

Mark, Worwood, ed. Iron metabolism. Baillière Tindall, 2002.

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3

Khalimonchuk, Oleh, ed. Iron Metabolism. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-4043-2.

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4

Wick, Manfred, Wulf Pinggera, and Paul Lehmann. Ferritin in Iron Metabolism. Springer Vienna, 1995. http://dx.doi.org/10.1007/978-3-7091-4421-3.

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Wick, Manfred, Wulf Pinggera, and Paul Lehmann. Ferritin in Iron Metabolism. Springer Vienna, 1991. http://dx.doi.org/10.1007/978-3-7091-4435-0.

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1938-, Lönnerdal Bo, ed. Iron metabolism in infants. CRC Press, 1990.

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Crichton, Robert R. Inorganic biochemistry of iron metabolism. E. Horwood, 1991.

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8

C, Hershko, ed. Clinical disorders of iron metabolism. Baillière Tindall, 1994.

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9

Chang, Yan-Zhong, ed. Brain Iron Metabolism and CNS Diseases. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-9589-5.

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Wick, Manfred, Wulf Pinggera, and Paul Lehmann. Iron Metabolism, Anemias. Diagnosis and Therapy. Springer Vienna, 2000. http://dx.doi.org/10.1007/978-3-7091-3909-7.

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Capitoli di libri sul tema "Iron Metabolism"

1

Koscielny, J., and H. Kiesewetter. "Iron Metabolism." In Hemodilution. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-662-07748-1_1.

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2

Wick, Manfred, Wulf Pinggera, and Paul Lehmann. "Iron Metabolism." In Clinical Aspects and Laboratory — Iron Metabolism, Anemias. Springer Vienna, 2011. http://dx.doi.org/10.1007/978-3-7091-0087-5_2.

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3

Wick, Manfred, Paul Lehmann, and Wulf Pinggera. "Iron Metabolism." In Clinical Aspects and Laboratory Iron Metabolism, Anemias. Springer Vienna, 2003. http://dx.doi.org/10.1007/978-3-7091-3719-2_2.

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4

Fellman, Vineta. "Iron Metabolism Disorders." In Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-40337-8_40.

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Ponka, Prem, and Alex D. Sheftel. "Erythroid Iron Metabolism." In Iron Physiology and Pathophysiology in Humans. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-60327-485-2_10.

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Philpott, Caroline C. "Yeast Iron Metabolism." In Iron Physiology and Pathophysiology in Humans. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-60327-485-2_30.

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Youdim, M. B. H. "Brain Iron Metabolism." In Pathological Neurochemistry. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4757-0797-7_27.

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Ganz, Tomas. "Systemic Iron Metabolism." In Advances in Experimental Medicine and Biology. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-92033-2_3.

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Bradeen, Heather, Samir Shehab, and Michael Recht. "Iron Metabolism and Iron Deficiency Anemia." In Textbook of Clinical Pediatrics. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-02202-9_318.

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Sikka, Meera, and Harresh B. Kumar. "Iron Metabolism and Iron Deficiency Anemia." In Hematopathology. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-7713-6_2.

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Atti di convegni sul tema "Iron Metabolism"

1

Chandrasekaran, P., and S. C. Dexter. "Bacterial Metabolism in Biofilm Consortia: Consequences for Potential Ennoblement." In CORROSION 1994. NACE International, 1994. https://doi.org/10.5006/c1994-94276.

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Abstract Platinum metal coupons were used in studying the mechanism of ennoblement in the presence of mature seawater biofilms. Presence of a bacterial consortia, rather than any single organism is determined to be necessary for ennoblement. Millimolar concentrations of iron and manganese were measured in biofilms formed over platinum. EDAX and ICP techniques were used for measuring the chemistry of particles in a biofilm. Utilization of various electron acceptors like oxygen, iron, manganese etc are thought to be important for ennoblement to take place over platinum. Heavy metal accumulation

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2

Lutterbach, M. T. S., L. S. Contador, A. L. C. Oliveira, M. M. Galvão, F. P. de França, and G. de Souza Pimenta. "Iron Sulfide Production by Shewanella Strain Isolated from Black Powder." In CORROSION 2009. NACE International, 2009. https://doi.org/10.5006/c2009-09391.

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Abstract Biocorrosion is a serious problem affecting oil and gas industry facilities throughout the world. Traditionally, the sulfate-reducing bacteria group has been considered the foremost responsible for microbially-influenced corrosion (MIC). However, recent studies suggest that other bacteria such as metal-reducing bacteria and methanogens may play a key role in biocorrosion. Shewanella are facultative anaerobic iron-reducing bacteria that are well known for their versatile metabolism. These bacteria have the ability to reduce ferric iron and sulfite, oxidize hydrogen gas, and produce sul

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3

Leach, David G., Wei Wang, Chao Yan, Dillon Mattis, Ron MacLeod, and Wei Wei. "Molecular Deep Dive into Oilfield Microbiologically Influenced Corrosion: a Detailed Case Study of MIC Failure Analysis in an Unconventional Asset." In CONFERENCE 2022. AMPP, 2022. https://doi.org/10.5006/c2022-17948.

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Abstract This work details a microbiologically influenced corrosion (MIC) failure analysis case study for a produced water pipeline. A pipeline in a shale and tight asset experienced heavy corrosion and ultimate failure within a 7-month period, with estimated corrosion rate at 161 mils per year (MPY), or 4.1 mm per year (MMPY). Upon removal by the inspection team, heavy white deposit buildup (a suspected microbial biofilm) was observed directly associated with the corrosion failure on top of a black scale underlayer. Detailed assessments were performed using ATP photometry, qPCR speciation, an

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4

Wang, Hua, Lu-Kwang Ju, Homero Castaneda, Gang Cheng, and Bi-min Zhang Newby. "Corrosion Behaviors of Carbon Steel and Stainless Steel in the Presence of Iron Oxidizing Bacteria Acidithiobacillus Ferrooxidans." In CORROSION 2015. NACE International, 2015. https://doi.org/10.5006/c2015-06060.

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Abstract In this study, corrosion behaviors of carbon steel UNS G10100 and stainless steel UNS S30400 in the presence of an iron-oxidizing bacterial species: Acidithiobacillus ferrooxidans, were examined. Results showed that A. ferrooxidans cells, with or without attaching to coupons, could accelerate UNS G10100 corrosion at a rate of 3 – 6× that of controls without A. ferrooxidans, but showed no effect on UNS S30400 corrosion. The accelerated corrosion of UNS G10100 by A. ferrooxidans cells was due to the presence of Fe3+, produced by the metabolism of A. ferrooxidans cells when utilizing Fe2

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5

Yang, Yan, Rajan Ambat, Riccardo Rizzo, and Magdalena Rogowska. "Multipronged Characterization of Scales and Corrosion on L80 Steel in the Presence of Microorganism." In CORROSION 2019. NACE International, 2019. https://doi.org/10.5006/c2019-13226.

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Abstract Scale deposit and corrosion attack on the L80 steel were observed using several analytical techniques, including 3D scanning microscopy, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD). This multipronged approach provided a more complete image and component of the species found on the steel surface. Cross-sectional SEM examinations showed the distribution and characteristic of scale. The results of EDS revealed that Fe, O and S were the most abundant elements in the scale layer, and the component analysis results showed that iron hy

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6

Penkala, Joseph E., Melissa D. Law, Allen L. Dickinson, Darin Horaska, Jerry Conaway, and Hector Soto. "Acrolein, 2-Propenal: A Versatile Microbiocide for Control of Bacteria in Oilfield Systems." In CORROSION 2004. NACE International, 2004. https://doi.org/10.5006/c2004-04749.

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Abstract Acrolein (2-propenal) is a microbiocide that has been used to mitigate bacterial problems in oilfield systems. The applications are widespread and include production and injection wells, surface equipment, and water injection systems. The applications include both onshore and offshore facilities throughout the world. The purported biocidal mechanism is the attack of sulfhydryl and amine groups on bacterial proteins by the a,ß-conjugated double bond resulting in disruption of enzyme systems and destruction of integrity of structural proteins. The reactivity with sulfides also renders a

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Gu, Tingyue, and Dake Xu. "Why Are Some Microbes Corrosive and Some Not?" In CORROSION 2013. NACE International, 2013. https://doi.org/10.5006/c2013-02336.

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Abstract Biocorrosion is also known as microbial corrosion and microbiologically influenced (or induced) corrosion (MIC). Biofilms are responsible for MIC. At least three different types of MIC can be defined. Type I MIC involves microbes such as sulfate reducing bacteria (SRB), nitrate/nitrite reducing bacteria (NRB) and methanogens, which are collectively called “XRB,” in which “X” stands for sulfate, nitrate, nitrite, CO2 or another non-oxygen oxidant and “B” for bugs that include prokaryotes, archaea and eucaryotes. These corrosive microbes respire on an oxidant to oxidize an organic carbo

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Pesic, B., and V. C. Storhok. "Biocorrosion of Iron with Thiobacillus Ferrooxidans-Linear Polarization Study." In CORROSION 2001. NACE International, 2001. https://doi.org/10.5006/c2001-01255.

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Abstract Corrosion reactions between T. ferrooxidans and pure iron were studied by using linear polarization technique. The effect of pH on corrosion was the main focus of this study. Experiments were performed at pH 1.0,2.0,3.0 and 4.0 under controlled and uncontrolled conditions. In addition to the corrosion kinetic parameters (Icorr, Ecorr, and Rp), the redox potential and pH changes for the uncontrolled case were also monitored over time. In-situ imaging was done by an Atomic Force Microscope in tapping mode and also by a digital video camera. Biocorrosion of iron differs from abiotic corr

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Puckorius, Paul R., and K. Anthony Selby. "Microorganisms in Cooling Water Systems - Case Histories: Detrimental and Beneficial Effects." In CORROSION 1993. NACE International, 1993. https://doi.org/10.5006/c1993-93312.

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Abstract Microbiologically influenced corrosion (MIC) has become well recognized as a major contributing factor in industrial corrosion. Not only are MIC related failures costly in terms of repair and replacement costs, they can compromise the safety related systems in nuclear power plants.1 A variety of bacterial organisms are involved in the MIC phenomenon. Thiobacillus and others are acid producing bacteria (APB) that produce mineral acids which attack mild steel and other piping/heat exchanger materials. Gallionella, Sphaerolitus and others are iron oxidizing or iron depositing bacteria th

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Yao, Yasuko, Katumi Masamura, Takaaki Kondo, and Yumi Ujiie. "Effect of Iron-Oxidizing Bacteria on the Corrosion Behavior of Type 304 Stainless Steel." In CORROSION 1999. NACE International, 1999. https://doi.org/10.5006/c1999-99166.

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Abstract The influence of iron-oxidizing bacteria, Thiobacillus ferrooxidans, grown in a ferrous ion-free medium, on the corrosion of type 304 stainless steel (UNS S30400) was evaluated. Electrochemical measurements were performed, both in the inoculated and in the sterile media. Corrosion potential (Ecorr) for type 304 stainless steel exposed in the bacterial culture was shifted near + 230 mV vs S.C.E. Cyclic voltammograms showed significant differences, a reduction peak was detected near -400 mV vs S.C.E. in the presence of the bacterial culture. This effect was most probably due to small qu

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Rapporti di organizzazioni sul tema "Iron Metabolism"

1

Kanner, Joseph, Dennis Miller, Ido Bartov, John Kinsella, and Stella Harel. The Effect of Dietary Iron Level on Lipid Peroxidation of Muscle Food. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7604282.bard.

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Biological oxidations are almost exclusively metal ion-promoted reactions and in ths respect iron, being the most abundant, is the commonly involved. The effect of dietary iron levels on pork, turkey and chick muscle lipid peroxidation and various other related compounds were evaluated. Crossbred feeder pigs were fed to market weight on corn-soy rations containing either 62, 131 or 209 ppm iron. After slaughter, the muscles were dissected, cooked and stored at 4°C. Heavily fortifying swine rations with iron (>200 ppm) increase nn-heme iron (NHI), thiobarbituric acid reactive substances (TBA

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2

Ades, Dennis. The role of iron nutrition in regulating patterns of photosynthesis and nitrogen metabolism in the green alga Scenedesmus quadricauda. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.5533.

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3

Blumwald, Eduardo, and Avi Sadka. Citric acid metabolism and mobilization in citrus fruit. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7587732.bard.

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Accumulation of citric acid is a major determinant of maturity and fruit quality in citrus. Many citrus varieties accumulate citric acid in concentrations that exceed market desires, reducing grower income and consumer satisfaction. Citrate is accumulated in the vacuole of the juice sac cell, a process that requires both metabolic changes and transport across cellular membranes, in particular, the mitochondrial and the vacuolar (tonoplast) membranes. Although the accumulation of citrate in the vacuoles of juice cells has been clearly demonstrated, the mechanisms for vacuolar citrate homeostasi

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4

Stefanova, Katya, Ginka Delcheva, Teodora Stankova, et al. sRANKL, OPG and sRAGE as Markers of Bone Metabolism in Rheumatoid Arthritis: Relation to Indicators of Impaired Iron Homeostasis and Inflammation. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, 2021. http://dx.doi.org/10.7546/crabs.2021.08.16.

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Splitter, Gary A., Menachem Banai, and Jerome S. Harms. Brucella second messenger coordinates stages of infection. United States Department of Agriculture, 2011. http://dx.doi.org/10.32747/2011.7699864.bard.

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Aim 1: To determine levels of this second messenger in: a) B. melitensiscyclic-dimericguanosinemonophosphate-regulating mutants (BMEI1448, BMEI1453, and BMEI1520), and b) B. melitensis16M (wild type) and mutant infections of macrophages and immune competent mice. (US lab primary) Aim 2: To determine proteomic differences between Brucelladeletion mutants BMEI1453 (high cyclic-dimericguanosinemonophosphate, chronic persistent state) and BMEI1520 (low cyclicdimericguanosinemonophosphate, acute virulent state) compared to wild type B. melitensisto identify the role of this second messenger in esta

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6

Choudhary, Ruplal, Victor Rodov, Punit Kohli, Elena Poverenov, John Haddock, and Moshe Shemesh. Antimicrobial functionalized nanoparticles for enhancing food safety and quality. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7598156.bard.

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Original objectives The general goal of the project was to utilize the bactericidal potential of curcumin- functionalizednanostructures (CFN) for reinforcement of food safety by developing active antimicrobial food-contact surfaces. In order to reach the goal, the following secondary tasks were pursued: (a) further enhancement of the CFN activity based on understanding their mode of action; (b) preparing efficient antimicrobial surfaces, investigating and optimizing their performance; (c) testing the efficacy of the antimicrobial surfaces in real food trials. Background to the topic The projec

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Cytryn, Eddie, Mark R. Liles, and Omer Frenkel. Mining multidrug-resistant desert soil bacteria for biocontrol activity and biologically-active compounds. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7598174.bard.

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Control of agro-associated pathogens is becoming increasingly difficult due to increased resistance and mounting restrictions on chemical pesticides and antibiotics. Likewise, in veterinary and human environments, there is increasing resistance of pathogens to currently available antibiotics requiring discovery of novel antibiotic compounds. These drawbacks necessitate discovery and application of microorganisms that can be used as biocontrol agents (BCAs) and the isolation of novel biologically-active compounds. This highly-synergistic one year project implemented an innovative pipeline aimed

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