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Letteratura scientifica selezionata sul tema "Ion channels"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 31 luglio 2024

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Articoli di riviste sul tema "Ion channels"

1

Johnkennedy, Nnodim, Bako Hauwa e Ezekwesiri Cletus. "Perspective of Ion Channels in Prostate Cancer". Sumerianz Journal of Medical and Healthcare, n. 42 (6 aprile 2021): 69–72. http://dx.doi.org/10.47752/sjmh.42.69.72.

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Ion channels are membrane proteins, which play a great role in regulating cellular excitability. Alteration of ion channel may contribute to prostate cancer. This could be linked to inherited mutations of ion channel genes which alter channel’s biophysical properties, in a prostate cancer. It is an observed fact that genomic instability is the main cause as well as the major characteristics of prostate cancer. Prostate cancer cell genotypes are mainly characterized by uncontrolled metastasis, resistance to programmed cell death, sustained angiogenesis as well as tissue invasion and metastasis. It is known that genes encoding ion channels are affected in prostate cancer. The Membrane proteins which is involved in signaling in cell and among cells, for coupling of extracellular events with intracellular responses, and for maintaining intracellular ionic homeostasis ion channels which contribute to some extents to pathophysiological features of each prostate cancer.

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2

Johnkennedy, Nnodim, Bako Hauwa e Ezekwesiri Cletus. "Perspective of Ion Channels in Prostate Cancer". Sumerianz Journal of Medical and Healthcare, n. 42 (6 aprile 2021): 72–75. http://dx.doi.org/10.47752/sjmh.42.72.75.

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Abstract (sommario):

Ion channels are membrane proteins, which play a great role in regulating cellular excitability. Alteration of ion channel may contribute to prostate cancer. This could be linked to inherited mutations of ion channel genes which alter channel’s biophysical properties, in a prostate cancer. It is an observed fact that genomic instability is the main cause as well as the major characteristics of prostate cancer. Prostate cancer cell genotypes are mainly characterized by uncontrolled metastasis, resistance to programmed cell death, sustained angiogenesis as well as tissue invasion and metastasis. It is known that genes encoding ion channels are affected in prostate cancer. The Membrane proteins which is involved in signaling in cell and among cells, for coupling of extracellular events with intracellular responses, and for maintaining intracellular ionic homeostasis ion channels which contribute to some extents to pathophysiological features of each prostate cancer.

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3

Hedrich, Rainer. "Ion Channels in Plants". Physiological Reviews 92, n. 4 (ottobre 2012): 1777–811. http://dx.doi.org/10.1152/physrev.00038.2011.

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Since the first recordings of single potassium channel activities in the plasma membrane of guard cells more than 25 years ago, patch-clamp studies discovered a variety of ion channels in all cell types and plant species under inspection. Their properties differed in a cell type- and cell membrane-dependent manner. Guard cells, for which the existence of plant potassium channels was initially documented, advanced to a versatile model system for studying plant ion channel structure, function, and physiology. Interestingly, one of the first identified potassium-channel genes encoding the Shaker-type channel KAT1 was shown to be highly expressed in guard cells. KAT1-type channels from Arabidopsis thaliana and its homologs from other species were found to encode the K+-selective inward rectifiers that had already been recorded in early patch-clamp studies with guard cells. Within the genome era, additional Arabidopsis Shaker-type channels appeared. All nine members of the Arabidopsis Shaker family are localized at the plasma membrane, where they either operate as inward rectifiers, outward rectifiers, weak voltage-dependent channels, or electrically silent, but modulatory subunits. The vacuole membrane, in contrast, harbors a set of two-pore K+ channels. Just very recently, two plant anion channel families of the SLAC/SLAH and ALMT/QUAC type were identified. SLAC1/SLAH3 and QUAC1 are expressed in guard cells and mediate Slow- and Rapid-type anion currents, respectively, that are involved in volume and turgor regulation. Anion channels in guard cells and other plant cells are key targets within often complex signaling networks. Here, the present knowledge is reviewed for the plant ion channel biology. Special emphasis is drawn to the molecular mechanisms of channel regulation, in the context of model systems and in the light of evolution.

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4

Roux, Benoît. "Ion channels and ion selectivity". Essays in Biochemistry 61, n. 2 (9 maggio 2017): 201–9. http://dx.doi.org/10.1042/ebc20160074.

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Specific macromolecular transport systems, ion channels and pumps, provide the pathways to facilitate and control the passage of ions across the lipid membrane. Ion channels provide energetically favourable passage for ions to diffuse rapidly and passively according to their electrochemical potential. Selective ion channels are essential for the excitability of biological membranes: the action potential is a transient phenomenon that reflects the rapid opening and closing of voltage-dependent Na+-selective and K+-selective channels. One of the most critical functional aspects of K+ channels is their ability to remain highly selective for K+ over Na+ while allowing high-throughput ion conduction at a rate close to the diffusion limit. Permeation through the K+ channel selectivity filter is believed to proceed as a ‘knockon’ mechanism, in which 2–3 K+ ions interspersed by water molecules move in a single file. Permeation through the comparatively wider and less selective Na+ channels also proceeds via a loosely coupled knockon mechanism, although the ions do not need to be fully dehydrated. While simple structural concepts are often invoked to rationalize the mechanism of ion selectivity, a deeper analysis shows that subtle effects play an important role in these flexible dynamical structures.

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5

Johnkennedy, Nnodim. "Disorders associated with Ion Channels". Journal of Clinical and Medical Reviews 1, n. 2 (29 dicembre 2022): 01–03. http://dx.doi.org/10.58489/2836-2330/007.

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Muscular wasting, a lack of muscle tone, or sporadic muscle paralysis are the most common symptoms of ion channel diseases, which are linked to defects in the proteins known as ion channels. Ion channels are diverse and differ with respect to how they open and close (gating) and their ionic conductance and selectivity (permeation). The development of novel molecules to modulate their activity, fundamental understanding of ion channel structure-function mechanisms, their physiological functions, how their dysfunction results in disease, their use as biosensors, and their utility as biosensors are important and active research frontiers. With a particular emphasis on voltage-gated ion channels, ion-channel engineering methods that have been used to investigate these facets of ion channel function are x-rayed.

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6

Ślęczkowska, Milena, Kaalindi Misra, Silvia Santoro, Monique M. Gerrits e Janneke G. J. Hoeijmakers. "Ion Channel Genes in Painful Neuropathies". Biomedicines 11, n. 10 (29 settembre 2023): 2680. http://dx.doi.org/10.3390/biomedicines11102680.

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Neuropathic pain (NP) is a typical symptom of peripheral nerve disorders, including painful neuropathy. The biological mechanisms that control ion channels are important for many cell activities and are also therapeutic targets. Disruption of the cellular mechanisms that govern ion channel activity can contribute to pain pathophysiology. The voltage-gated sodium channel (VGSC) is the most researched ion channel in terms of NP; however, VGSC impairment is detected in only <20% of painful neuropathy patients. Here, we discuss the potential role of the other peripheral ion channels involved in sensory signaling (transient receptor potential cation channels), neuronal excitation regulation (potassium channels), involuntary action potential generation (hyperpolarization-activated cyclic nucleotide-gated channels), thermal pain (anoctamins), pH modulation (acid sensing ion channels), and neurotransmitter release (calcium channels) related to pain and their prospective role as therapeutic targets for painful neuropathy.

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7

Pozdnyakov, Ilya, Olga Matantseva e Sergei Skarlato. "Consensus channelome of dinoflagellates revealed by transcriptomic analysis sheds light on their physiology". Algae 36, n. 4 (15 dicembre 2021): 315–26. http://dx.doi.org/10.4490/algae.2021.36.12.2.

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Ion channels are membrane protein complexes mediating passive ion flux across the cell membranes. Every organism has a certain set of ion channels that define its physiology. Dinoflagellates are ecologically important microorganisms characterized by effective physiological adaptability, which backs up their massive proliferations that often result in harmful blooms (red tides). In this study, we used a bioinformatics approach to identify homologs of known ion channels that belong to 36 ion channel families. We demonstrated that the versatility of the dinoflagellate physiology is underpinned by a high diversity of ion channels including homologs of animal and plant proteins, as well as channels unique to protists. The analysis of 27 transcriptomes allowed reconstructing a consensus ion channel repertoire (channelome) of dinoflagellates including the members of 31 ion channel families: inwardly-rectifying potassium channels, two-pore domain potassium channels, voltage-gated potassium channels (Kv), tandem Kv, cyclic nucleotide-binding domain-containing channels (CNBD), tandem CNBD, eukaryotic ionotropic glutamate receptors, large-conductance calcium-activated potassium channels, intermediate/small-conductance calcium-activated potassium channels, eukaryotic single-domain voltage-gated cation channels, transient receptor potential channels, two-pore domain calcium channels, four-domain voltage-gated cation channels, cation and anion Cys-loop receptors, small-conductivity mechanosensitive channels, large-conductivity mechanosensitive channels, voltage-gated proton channels, inositole-1,4,5- trisphosphate receptors, slow anion channels, aluminum-activated malate transporters and quick anion channels, mitochondrial calcium uniporters, voltage-dependent anion channels, vesicular chloride channels, ionotropic purinergic receptors, animal volage-insensitive cation channels, channelrhodopsins, bestrophins, voltage-gated chloride channels H+/Cl- exchangers, plant calcium-permeable mechanosensitive channels, and trimeric intracellular cation channels. Overall, dinoflagellates represent cells able to respond to physical and chemical stimuli utilizing a wide range of Gprotein coupled receptors- and Ca2+-dependent signaling pathways. The applied approach not only shed light on the ion channel set in dinoflagellates, but also provided the information on possible molecular mechanisms underlying vital cellular processes dependent on the ion transport.

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Prevarskaya, Natalia, Roman Skryma e Yaroslav Shuba. "Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?" Physiological Reviews 98, n. 2 (1 aprile 2018): 559–621. http://dx.doi.org/10.1152/physrev.00044.2016.

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Genomic instability is a primary cause and fundamental feature of human cancer. However, all cancer cell genotypes generally translate into several common pathophysiological features, often referred to as cancer hallmarks. Although nowadays the catalog of cancer hallmarks is quite broad, the most common and obvious of them are 1) uncontrolled proliferation, 2) resistance to programmed cell death (apoptosis), 3) tissue invasion and metastasis, and 4) sustained angiogenesis. Among the genes affected by cancer, those encoding ion channels are present. Membrane proteins responsible for signaling within cell and among cells, for coupling of extracellular events with intracellular responses, and for maintaining intracellular ionic homeostasis ion channels contribute to various extents to pathophysiological features of each cancer hallmark. Moreover, tight association of these hallmarks with ion channel dysfunction gives a good reason to classify them as special type of channelopathies, namely oncochannelopathies. Although the relation of cancer hallmarks to ion channel dysfunction differs from classical definition of channelopathies, as disease states causally linked with inherited mutations of ion channel genes that alter channel's biophysical properties, in a broader context of the disease state, to which pathogenesis ion channels essentially contribute, such classification seems absolutely appropriate. In this review the authors provide arguments to substantiate such point of view.

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Vierra, Nicholas C., e James S. Trimmer. "Ion Channel Partnerships: Odd and Not-So-Odd Couples Controlling Neuronal Ion Channel Function". International Journal of Molecular Sciences 23, n. 4 (10 febbraio 2022): 1953. http://dx.doi.org/10.3390/ijms23041953.

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The concerted function of the large number of ion channels expressed in excitable cells, including brain neurons, shapes diverse signaling events by controlling the electrical properties of membranes. It has long been recognized that specific groups of ion channels are functionally coupled in mediating ionic fluxes that impact membrane potential, and that these changes in membrane potential impact ion channel gating. Recent studies have identified distinct sets of ion channels that can also physically and functionally associate to regulate the function of either ion channel partner beyond that afforded by changes in membrane potential alone. Here, we review canonical examples of such ion channel partnerships, in which a Ca2+ channel is partnered with a Ca2+-activated K+ channel to provide a dedicated route for efficient coupling of Ca2+ influx to K+ channel activation. We also highlight examples of non-canonical ion channel partnerships between Ca2+ channels and voltage-gated K+ channels that are not intrinsically Ca2+ sensitive, but whose partnership nonetheless yields enhanced regulation of one or the other ion channel partner. We also discuss how these ion channel partnerships can be shaped by the subcellular compartments in which they are found and provide perspectives on how recent advances in techniques to identify proteins in close proximity to one another in native cells may lead to an expanded knowledge of other ion channel partnerships.

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10

Kaupp, U. Benjamin, e Reinhard Seifert. "Cyclic Nucleotide-Gated Ion Channels". Physiological Reviews 82, n. 3 (7 gennaio 2002): 769–824. http://dx.doi.org/10.1152/physrev.00008.2002.

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Cyclic nucleotide-gated (CNG) channels are nonselective cation channels first identified in retinal photoreceptors and olfactory sensory neurons (OSNs). They are opened by the direct binding of cyclic nucleotides, cAMP and cGMP. Although their activity shows very little voltage dependence, CNG channels belong to the superfamily of voltage-gated ion channels. Like their cousins the voltage-gated K+ channels, CNG channels form heterotetrameric complexes consisting of two or three different types of subunits. Six different genes encoding CNG channels, four A subunits (A1 to A4) and two B subunits (B1 and B3), give rise to three different channels in rod and cone photoreceptors and in OSNs. Important functional features of these channels, i.e., ligand sensitivity and selectivity, ion permeation, and gating, are determined by the subunit composition of the respective channel complex. The function of CNG channels has been firmly established in retinal photoreceptors and in OSNs. Studies on their presence in other sensory and nonsensory cells have produced mixed results, and their purported roles in neuronal pathfinding or synaptic plasticity are not as well understood as their role in sensory neurons. Similarly, the function of invertebrate homologs found in Caenorhabditis elegans, Drosophila,and Limulus is largely unknown, except for two subunits of C. elegans that play a role in chemosensation. CNG channels are nonselective cation channels that do not discriminate well between alkali ions and even pass divalent cations, in particular Ca2+. Ca2+ entry through CNG channels is important for both excitation and adaptation of sensory cells. CNG channel activity is modulated by Ca2+/calmodulin and by phosphorylation. Other factors may also be involved in channel regulation. Mutations in CNG channel genes give rise to retinal degeneration and color blindness. In particular, mutations in the A and B subunits of the CNG channel expressed in human cones cause various forms of complete and incomplete achromatopsia.

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Tesi sul tema "Ion channels"

1

Männikkö, Roope. "Voltage sensor movements in shaker and HCN channels /". Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-739-8.

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2

Donini, Oreola Anna Teresa. "Ion channels in motion, developing computational approaches to dynamic ion channel modeling". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ35957.pdf.

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3

Hoyles, Matthew, e Matthew Hoyles@anu edu au. "Computer Simulation of Biological Ion Channels". The Australian National University. Theoretical Physics, 2000. http://thesis.anu.edu.au./public/adt-ANU20010702.135814.

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This thesis describes a project in which algorithms are developed for the rapid and accurate solution of Poisson's equation in the presence of a dielectric boundary and multiple point charges. These algorithms are then used to perform Brownian dynamics simulations on realistic models of biological ion channels. An iterative method of solution, in which the dielectric boundary is tiled with variable sized surface charge sectors, provides the flexibility to deal with arbitrarily shaped boundaries, but is too slow to perform Brownian dynamics. An analytical solution is derived, which is faster and more accurate, but only works for a toroidal boundary. Finally, a method is developed of pre-calculating solutions to Poisson's equation and storing them in tables. The solution for a particular configuration of ions in the channel can then be assembled by interpolation from the tables and application of the principle of superposition. This algorithm combines the flexibility of the iterative method with greater speed even than the analytical method, and is fast enough that channel conductance can be predicted. The results of simulations for a model single-ion channel, based on the acetylcholine receptor channel, show that the narrow pore through the low dielectric strength medium of the protein creates an energy barrier which restricts the permeation of ions. They further show that this barrier can be removed by dipoles in the neck of the channel, but that the barrier is not removed by shielding by counter-ions. The results of simulations for a model multi-ion channel, based on a bacterial potassium channel, show that the model channel has conductance characteristics similar to those of real potassium channels. Ions appear to move through the model multi-ion channel via rapid transitions between a series of semi-stable states. This observation suggests a possible physical basis for the reaction rate theory of channel conductance, and opens up an avenue for future research.

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4

Craven, Kimberley Beth. "Structural rearrangements during gating in cyclic nucleotide-modulated channels /". Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/10654.

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5

Breed, Jason. "Molecular modelling of ion channels". Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308690.

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6

MacKenzie, Amanda Barbara. "Ion channels in human platelets". Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627035.

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7

Ball, Sue. "Stochastic models of ion channels". Thesis, University of Nottingham, 2001. http://eprints.nottingham.ac.uk/11277/.

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This thesis is concerned with models and inference for single ion channels. Molecular modelling studies are used as the basis for biologically realistic, large state-space gating models of the nicotinic acetylcholine receptor which enable single-channel kinetic behaviour to be characterized in terms of a small number of free parameters. A model is formulated which incorporates known structural information concerning pentameric subunit composition, interactions between neighbouring subunits and knowledge of the behaviour of agonist binding sites within the receptor-channel proteins. Expressions are derived for various channel properties and results are illustrated using numerical examples. The model is adapted and extended to demonstrate how properties of the calcium ion-activated potassium ion channel may be modelled. A two-state stochastic model for ion channels which incorporates time interval omission is examined. Two new methods for overcoming a non-identifiability problem induced by time interval omission are introduced and simulation studies are presented in support of these methods. A framework is presented for analysing the asymptotic behaviour of the method-of-moments estimators of the mean lengths of open and closed sojourns. This framework is used to clarify the origin of the non-identifiability and to construct confidence sets for the mean sojourn lengths. A conjecture concerning the number of solutions of the moment estimating equations is proved.

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Swallow, Isabella Diane. "Probes for bacterial ion channels". Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:d42d13dd-dd0c-451b-bd00-e06f84350335.

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Using three complementary approaches, this work sought to tackle the widespread problem of antibiotic resistance. To circumvent the resistance mechanisms developed by bacteria, it is necessary to establish drug candidates that act on novel therapeutic targets, such as the ion channels used by bacteria to modulate homeostasis. Examples include the potassium efflux channel, Kef, and the mechanosensitive channel of small conductance, MscS, which are not found in humans. How these targets function must be well understood before drug candidates can be developed, as such, their identification and investigation is often accompanied by the evolution of the analytical techniques used to study them. Membrane protein mass spectrometry is one technique showing potential in the study of ion channels. However, spectra can be clouded by the detergents used to solubilise ion channels from their native membranes. Undertaken herein was the synthesis of some fluorescent glycolipid detergents, which it was hypothesised could be encouraged to dissociate from ion channels via laser-induced excitation within the gas phase of a mass spectrometer, thereby improving the clarity with which spectra can be obtained. For Kef, an unconfirmed mechanism of action had previously been proposed. To explore the suggestion that sterically-demanding central residues are important for channel activation, solid phase peptide synthesis was used to isolate three tripeptide analogues of N-ethylsuccinimido glutathione, a known activator with a high affinity for Kef. A competition fluorescence assay suggested these tripeptides bound to Kef with an affinity lower than predicted, allowing the conclusion that a more detailed assessment of the steric bulk required for activation was necessary before a mechanism of action could be confirmed. Lysophosphatidylcholine has been shown to activate MscS, although it is not known how. Affinity chromatography between MscS and lysophosphatidylcholine was proposed as a means by which specific binding interactions could be investigated. For this technique an amino-derivative of lysophosphatidylcholine was necessary and its challenging synthesis is also detailed herein.

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9

Matulef, Kimberly Irene. "Cysteine-scanning mutagenesis of the ligand-binding domain of cyclic nucleotide-gated channels /". Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/5032.

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10

Zhang, Hongling. "Sigma Receptors Modulation of Voltage-gated Ion Channels in Rat Autonomic Neurons". [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001183.

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Libri sul tema "Ion channels"

1

Stockand, James D., e Mark S. Shapiro, a cura di. Ion Channels. Totowa, NJ: Humana Press, 2006. http://dx.doi.org/10.1385/1597450952.

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2

Gamper, Nikita, a cura di. Ion Channels. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-351-0.

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3

Narahashi, Toshio, a cura di. Ion Channels. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-1775-1.

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4

Narahashi, Toshio, a cura di. Ion Channels. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4615-7302-9.

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5

Narahashi, Toshio, a cura di. Ion Channels. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4615-7305-0.

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6

Fermini, Bernard, e Birgit T. Priest, a cura di. Ion Channels. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-79729-6.

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Narahashi, Toshio, a cura di. Ion Channels. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3328-3.

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8

Toshio, Narahashi, a cura di. Ion channels. New York: Plenum, 1990.

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9

Toshio, Narahashi, a cura di. Ion channels. New York: Plenum Press, 1988.

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10

Narahashi, Toshio. Ion Channels. Boston, MA: Springer US, 1992.

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Capitoli di libri sul tema "Ion channels"

1

Böttger, Angelika, Ute Vothknecht, Cordelia Bolle e Alexander Wolf. "Ion Channels". In Lessons on Caffeine, Cannabis & Co, 43–56. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-99546-5_4.

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2

Hou, Xiaowei. "Ion Channels". In Advances in Membrane Proteins, 17–45. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-0532-0_2.

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3

Yee, Nelson. "Ion Channels". In Encyclopedia of Cancer, 1–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27841-9_3137-4.

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4

Nelson, Deborah J., e Harry A. Fozzard. "Ion Channels". In Principles of Molecular Regulation, 135–48. Totowa, NJ: Humana Press, 2000. http://dx.doi.org/10.1007/978-1-59259-032-2_8.

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5

Yee, Nelson. "Ion Channels". In Encyclopedia of Cancer, 2346–50. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-46875-3_3137.

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6

Bennekou, Poul, e Palle Christophersen. "Ion Channels". In Red Cell Membrane Transport in Health and Disease, 139–52. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05181-8_6.

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7

White, Stephen H., Gunnar von Heijne e Donald M. Engelman. "Ion Channels". In Cell Boundaries, 355–98. New York: Garland Science, 2021. http://dx.doi.org/10.1201/9780429341328-12.

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8

Wu, Chun-Fang, e Barry Ganetzky. "Neurogenetic Studies of Ion Channels in Drosophila". In Ion Channels, 261–314. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3328-3_9.

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9

Huang, Chou-Long. "Probing the Effects of Phosphoinositides on Ion Channels". In Ion Channels, 81–87. Totowa, NJ: Humana Press, 2006. http://dx.doi.org/10.1385/1-59745-095-2:81.

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10

Guy, H. Robert, e Stewart R. Durell. "Developing Three-Dimensional Models of Ion Channel Proteins". In Ion Channels, 1–40. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-1775-1_1.

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Atti di convegni sul tema "Ion channels"

1

Wilson, Jim R., e Neil A. Duncan. "Modelling the Ion Channel Behaviour of Articular Chondrocytes". In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32661.

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All cells have a membrane potential; this voltage difference arises from the different intracellular and extracellular ion concentrations. In excitable tissue the cell membranes contain ion channels which control the movement of ions and hence control the cell’s membrane potential. Extensive measurements of the electrophysiology of excitable cells has allowed considerable understanding of the ion channels. The Hodgkin-Huxley model [1] was developed from measurements on a squid nerve axon, and it quantifies the changes in membrane conductance due to the opening and closing of specific ion channels. This model has been very successful in describing the electrical behaviour of neurons. Ion channels also exist in non-excitable tissue cells. Patch clamp experiments have demonstrated that ion channels in chondrocytes influence cell’s membrane potential [2]; controls the influx of Ca2+ [3] and may regulate cell proliferation [2]. The objective of this research was to develop a model of ion channel behaviour for connective tissue cells based on the Hodgkin-Huxley model, and to apply this model to reported patch clamp measurements of articular chondrocytes.

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2

Creasy, M. Austin, e Donald J. Leo. "Modeling the Conductance of the Peptide Alamethicin With and Without Ion Gradients". In ASME 2011 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2011. http://dx.doi.org/10.1115/smasis2011-5117.

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Alamethicin is an antibiotic peptide from the fungus Trichoderma viride that forms ion channels in bilayer lipid membranes. Each peptide consists of 20 amino acids that can form larger channels with the congregation of multiple monomers of the peptide. These formed ion channels have some voltage dependent characteristics when a potential is induced across the bilayer. This potential can be from an applied voltage source or from an ion concentration gradient inducing a transmembrane potential across the membrane. The peptide alamethicin can be modeled as a conductor that allows the flow of ions through the membrane. The formed channels have distinct conductance level states caused by accumulation of additional alamethicin monomers being added to an individual ion channel. The voltage dependence of the accumulation of multiple ion channels can be modeled for the average response. A probabilistic model is used to capture the statistics of the state changes of individual channels. This type of model can be summed to simulate the conductance of multiple channels within a bilayer. This work focuses on obtaining the statistic for individual ion channels and using those statistics to show that a probabilistic model of the peptide’s conductance can capture some of the dynamics seen in aggregated responses. The Nernst equation is used to estimate the transmembrane potential caused by an ion gradient of a bilayer in equilibrium. This potential is used in the model to assist in determining the current conductance states of an individual channel of the peptide in the presence of an ion gradient. This paper will show the experimental results of ion currents across a bilayer induced by membrane potentials and the ion currents induced by ion gradients. The statistics of the measurements are used in a probabilistic conductance model of the peptide alamethicin.

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3

Chang, Chen-Ling, John Guofeng Bai, Kyong-Hoon Lee, Jae-Hyun Chung, Yaling Liu e Wing Kam Liu. "Ion Diffusion Upon Concentrations in Open Nanofluidic Channels". In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-42362.

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The ion flow in nanochannels is investigated by using nanochannels in an open configuration that allows the direct observation of fluid diffusion through an optical microscope. An “open nanochannel” is a channel with the top open to air such that fluidics can be introduced from both the entrance and the top of the channels. The experimental results showed that the diffusion length of the potassium chloride and phosphate buffer decreased with their concentration. The observed behaviors were analyzed by the contact angle variation due to the electrowetting phenomena involving the interaction between electrical double layer and counter-ions in the solution.

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4

Latu, Mariana. "Nanostructure of ion channels". In Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IV, a cura di Paul Schiopu, Cornel Panait, George Caruntu e Adrian Manea. SPIE, 2009. http://dx.doi.org/10.1117/12.823673.

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5

Cuppoletti, John, Christopher J. Ferrante e Danuta H. Malinowska. "Engineered Ion Channels on Synthetic Flexible Membranes: Ion Channel Devices With Focus on Peptides". In ASME 2009 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2009. http://dx.doi.org/10.1115/smasis2009-1243.

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Recent studies of engineered ion channels on synthetic flexible membranes realized unprecedented materials properties. Starting with ion channels of known sequence and crystal structures, these studies outlined the structural basis for functional and regulatory properties, and developed new computational tools capable of predicting structural and functional properties of the native ion channels as well as native or engineered ion channels that were similar in structure to each other. The approaches taken to prepare the engineered composite membranes and the computational tools are generally applicable to the development, design and prediction of properties of a wide variety of materials such as selectively permeable membranes or functionalized thin films with desired chemical, electrical or optical properties. ClC-2 Cl− transporting channels and related ion channels were used for this work. The following major developments have facilitated this work. First, the X-ray crystal structure of a bacterial ClC Cl− channel was published and our group has been able to use that information in computational studies to develop structures for ClC channels and their transport mechanisms. Recent NMR and X-ray crystal structural studies have given important new information regarding the structure of the intracellular region, and this information helps to explain the structural basis for our findings that this same region is involved in phosphorylation-dependent regulation of the channel. Dissection and reconstitution of this region has already been carried out, raising our level of confidence that we can exploit this regulatory region to develop sensors in future studies. The group was then able to remove those native or engineered ion channels from cells, and place these onto a wide variety of synthetic supports without loss of function. This effort produced unique new materials with the ability to “sense” the environment and at the same time send an electrical signal reporting changes in the chemical or physical environment. These devices can sense chemicals and toxins and even shrink and swell or produce electrical energy from biochemicals. Indeed, the work contributes to a new field of engineering for producing materials with unprecedented properties. These materials can sense and report on chemical, physical and electromagnetic changes in the environment. In living cells, these ion channels other chemi-osmotic transport proteins use electrochemical gradients formed by light and chemical substrates to produce and interconvert energy, mechanical work, electrical work, osmotic work, chemical work and heat. Guided by new predictive computational approaches, these composite materials will do the same.

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6

Zöller, A., R. Götzelmann, K. Matl e D. Cushing. "Shift free interference coatings deposited with plasma ion assisted deposition". In Optical Interference Coatings. Washington, D.C.: Optica Publishing Group, 1995. http://dx.doi.org/10.1364/oic.1995.tua7.

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The temperature stability of optical coatings becomes more and more important. Especially for telecommunication applications the requirements are very stringent. Since the number of channels of wavelengths increases and the wavelength distance between the channels decreases, it becomes more and more difficult to separate one wavelength channel from the other [1].

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7

Macrae, Michael X., Steven Blake, Thomas Mayer, Michael Mayer e Jerry Yang. "Reactive derivatives of gramicidin enable light- and ion-modulated ion channels". In SPIE NanoScience + Engineering, a cura di Manijeh Razeghi e Hooman Mohseni. SPIE, 2009. http://dx.doi.org/10.1117/12.827686.

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8

ZHONG, QINGFENG, THOMAS HUSSLEIN e MICHAEL L. KLEIN. "Ion channels: a challenge for computer simulations". In Proceedings of the International School of Physics. WORLD SCIENTIFIC, 1998. http://dx.doi.org/10.1142/9789812839664_0020.

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9

Agrawal, Divyansh, Sachin Minocha e Amit Kumar Goel. "Gradient Boosting Based Classification of Ion Channels". In 2021 International Conference on Computing, Communication, and Intelligent Systems (ICCCIS). IEEE, 2021. http://dx.doi.org/10.1109/icccis51004.2021.9397161.

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10

Kaufman, I. Kh, W. Gibby, D. G. Luchinsky, P. V. E. McClintock e R. S. Eisenberg. "Coulomb blockade oscillations in biological ion channels". In 2015 International Conference on Noise and Fluctuations (ICNF). IEEE, 2015. http://dx.doi.org/10.1109/icnf.2015.7288558.

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Rapporti di organizzazioni sul tema "Ion channels"

1

Toyoda, Hiroki. Ion channels involved in spontaneous pain. Science Repository OÜ, settembre 2018. http://dx.doi.org/10.31487/j.nnb.2018.02.001.

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2

Sachs, Frederick. Ligands for Stretch Activated Ion Channels. Fort Belvoir, VA: Defense Technical Information Center, maggio 1996. http://dx.doi.org/10.21236/ada315807.

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3

Spalding, Edgar P. Amino acid-sensing ion channels in plants. Office of Scientific and Technical Information (OSTI), agosto 2014. http://dx.doi.org/10.2172/1149488.

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4

Marshall, Garland R. Molecular Mechanism of Voltage-Dependent Ion Channels. Fort Belvoir, VA: Defense Technical Information Center, novembre 1990. http://dx.doi.org/10.21236/ada229777.

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5

Liedtke, Wolfgang. Role of Ca++ Influx via Epidermal TRP Ion Channels. Fort Belvoir, VA: Defense Technical Information Center, ottobre 2014. http://dx.doi.org/10.21236/ada620001.

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6

Schwindt, Peter C. Role of Spatially Distributed Ion Channels in Single Neuron Computation. Fort Belvoir, VA: Defense Technical Information Center, maggio 1993. http://dx.doi.org/10.21236/ada265972.

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7

Ikeda, Stephen R. Pain Transmission in Humans: The Role of Novel Sensory Ion Channels. Fort Belvoir, VA: Defense Technical Information Center, maggio 2001. http://dx.doi.org/10.21236/ada394901.

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8

Noti, John, Robert S. Aronstam, Stephen R. Ikeda, Henry L. Puhl e III. Pain Transmission in Humans: The Role of Novel Sensory Ion Channels. Fort Belvoir, VA: Defense Technical Information Center, maggio 2002. http://dx.doi.org/10.21236/ada406960.

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9

Notti, John D., e Robert S. Aronstam. Pain Transmission in Humans: The Role of Novel Sensory Ion Channels. Fort Belvoir, VA: Defense Technical Information Center, maggio 2003. http://dx.doi.org/10.21236/ada427161.

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10

Askwith, Candice C., e Dana McTigue. The Role of Acid Sensing Ion Channels in Spinal Cord Injury. Fort Belvoir, VA: Defense Technical Information Center, ottobre 2012. http://dx.doi.org/10.21236/ada581687.

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