Letteratura scientifica selezionata sul tema "Interleukin-12"
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Articoli di riviste sul tema "Interleukin-12"
Leonard, Patricia, e Sanjiv Sur. "Interleukin-12". BioDrugs 17, n. 1 (2003): 1–7. http://dx.doi.org/10.2165/00063030-200317010-00001.
Testo completo&NA;. "Interleukin-12". Inpharma Weekly &NA;, n. 1124 (febbraio 1998): 7. http://dx.doi.org/10.2165/00128413-199811240-00013.
Testo completoTrinchieri, Giorgio. "Interleukin-12". Clinical Immunotherapeutics 3, n. 4 (aprile 1995): 262–70. http://dx.doi.org/10.1007/bf03259278.
Testo completoClinton, Steven K., Eduardo Canto e Michael A. O'Donnell. "INTERLEUKIN-12". Urologic Clinics of North America 27, n. 1 (febbraio 2000): 147–55. http://dx.doi.org/10.1016/s0094-0143(05)70242-1.
Testo completoWeiner, David. "Plasmid Interleukin 12". AIDS 14, n. 12 (agosto 2000): 1759–60. http://dx.doi.org/10.1097/00002030-200008180-00010.
Testo completoLeng, S. X., e J. A. Elias. "Interleukin-11 inhibits macrophage interleukin-12 production." Journal of Immunology 159, n. 5 (1 settembre 1997): 2161–68. http://dx.doi.org/10.4049/jimmunol.159.5.2161.
Testo completoFox, Robert J., e Abdolmohamad M. Rostami. "Anti???Interleukin-12 Antibody". BioDrugs 13, n. 4 (aprile 2000): 233–41. http://dx.doi.org/10.2165/00063030-200013040-00002.
Testo completo&NA;. "Interleukin-12 trial halted". Reactions Weekly &NA;, n. 556 (giugno 1995): 2. http://dx.doi.org/10.2165/00128415-199505560-00003.
Testo completo&NA;. "Interleukin-12 studies continue". Reactions Weekly &NA;, n. 558 (luglio 1995): 2. http://dx.doi.org/10.2165/00128415-199505580-00003.
Testo completo&NA;. "Interleukin-12 trial halted". Inpharma Weekly &NA;, n. 992 (giugno 1995): 21. http://dx.doi.org/10.2165/00128413-199509920-00047.
Testo completoTesi sul tema "Interleukin-12"
Balu, Sucharitha. "Cloning and characterisation of chicken interleukin-12 and the interleukin-12 receptor". Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419213.
Testo completoSwinburne, Sarah Jane. "A study of the molecular and biological characteristics of ovine interleukin-12". Title page, contents and summary only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phs9777.pdf.
Testo completoWerner, Christoph. "Von Interleukin-12 zur p40-Zytokinfamilie Interleukin-12-unabhängige Wirkungen von p40-Zytokinen in der Infekt- und Tumorabwehr /". [S.l.] : [s.n.], 2003. http://dol.uni-leipzig.de/pub/2003-34.
Testo completoWerner, Christoph. "Von Interleukin-12 zur p40-Zytokinfamilie: Interleukin-12-unabhängige Wirkungen von p40-Zytokinen in der Infekt- und Tumorabwehr". Doctoral thesis, Universitätsbibliothek Leipzig, 2004. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-37550.
Testo completoInterleukin-12 (IL-12) is a key cytokine in the development of a protective cellular Th1 immune response. It consists of a p40 and a p35 subunit. Following stimulation with IL-12, NK and T cells produce large amounts of IFN-gamma resulting in a type 1 immune response. The p40 subunit of IL-12 is also part of other biologically active proteins such as monomeric or homodimeric p40 or the heterodimeric IL-23 (in combination with a p19 subunit). While in this study the homodimeric p40 appears to antagonize IL-12, IL-23 was demonstrated to have agonistic effects. The aim of this study was to investigate p40-dependent effects which can be observed independently of IL-12, i.e. potential effects mediated by IL-23. For the experiments mutant mice were used so that IL-12 dependent mechanisms could not play a role but only p40-dependent proteins excluding IL-12. In a Salmonella Enteritidis infection model p35-gene deleted (p35-/-) and p40-/- mice were used. As the expression of p40 is induced by bacterial antigen, differences between the strains were caused by the p40 protein. During the infection p40 proteins induced IFN-gamma production thus improving the killing of intracellular pathogens. This resulted in a better control of the systemic infection and longer survival periods of the p35-/- mice as compared to p40-/- mice. For the experiments in the tumor model using the Lewis-Lung carcinoma and the Melanoma B16 as tumors, p35/40-/- mice which are unable to produce any p40 proteins, received gene therapy with DNA encoding for p40. This local gene therapy resulted in a reduced tumor growth. Immunohistochemical examination revealed an infiltration of the tumor tissue with macrophages and a reduced neoangiogenesis within the tumor. This effect could not be achieved by local administration of IL-23 or the p40-homodimer as a protein, indicating the existence of an as yet unknown heterodimeric p40 protein. In vitro experiments showed that IL-23 induces IFN-gamma production by splenocytes and this effect can be antagonized by the homodimer. Interestingly, IL-23 is also able to antagonize IL-12 in primary splenocyte cultures. In vitro infection with Salmonella resulted in an p40-dependent IFN-gamma production that could also be antagonized by the homodimer. The protective effects in the infection model might be caused by IL-23, which is supported by the in vitro results. On the other hand, in the tumor model IL-23 does not seem to be the player and it must be concluded that the protective effects are caused by an other as yet unknown p40-dependent protein p40-x
Walter, Claudia. "Bestimmung der Zytokine Interleukin-1ra, Interleukin-6, Interleukin-10 und Interleukin-12 im Vaginalsekret bei Frauen mit Bakterieller Vaginose". Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-28461.
Testo completoChakir, Habiba. "Role of interleukin-12 and interleukin-18 in murine immune cell regulation". Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/28980.
Testo completoRempel, Julia D. "Interleukin-12 and interleukin-10 regulation of antibody responses upon protein antigen immunization". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ41623.pdf.
Testo completoAthie, Morales Veronica. "Interleukin 12 signalling pathways in human T lymphocytes". Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249566.
Testo completoSchardt, Victor. "Vergleichende Untersuchungen zur Hefepilzbesiedelung von Mundhöhle und Vagina und Bestimmung von Interleukin-4, Interleukin-10 und Interleukin-12". Diss., lmu, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-155152.
Testo completoNaseer, Tanveer 1971. "In vivo expression of interleukin-12 and interleukin-13 in the pathogenesis of asthma". Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23925.
Testo completoLibri sul tema "Interleukin-12"
Lasek, Witold, e Radoslaw Zagozdzon. Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46906-5.
Testo completoIl-12 (Chemical Immunology). S. Karger AG (Switzerland), 1997.
Cerca il testo completoInterleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology. Springer International Publishing AG, 2016.
Cerca il testo completoLasek, Witold, Radoslaw Zagozdzon e Marek Jakóbisiak. Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology. Springer, 2016.
Cerca il testo completoInterleukin 12: Cellular and molecular immunology of an important regulatory cytokine. New York, N.Y: New York Academy of Sciences, 1996.
Cerca il testo completoNew York Academy of Sciences (Corporate Author), Inc. Genetics Institute (Corporate Author) e Michael T. Lotze (Editor), a cura di. Interleukin 12: Cellular and Molecular Immunology of an Important Regulatory Cytokine (Annals of the New York Academy of Sciences, V. 795). New York Academy of Sciences, 1996.
Cerca il testo completo(Editor), Michael T. Lotze, Giorgio Trinchiere (Editor), Maurice Gately (Editor) e Stanley Wolf (Editor), a cura di. Interleukin 12: Cellular and Molecular Immunology of an Important Regulatory Cytokine (Annals of the New York Academy of Sciences). New York Academy of Sciences, 1996.
Cerca il testo completoConstruction of murine interleukin-12 retroviral Vectors: Implications for gene therapy of hematologic malignancies. Ottawa: National Library of Canada, 1996.
Cerca il testo completoCapitoli di libri sul tema "Interleukin-12"
Kaufman, Howard L., e Neal Dharmadhikari. "Interleukin-12". In Cancer Therapeutic Targets, 345–59. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4419-0717-2_144.
Testo completoDieckman, Tessa, Antonie Zwiers, Georg Kraal e Gerd Bouma. "Interleukin 12". In Compendium of Inflammatory Diseases, 709–14. Basel: Springer Basel, 2016. http://dx.doi.org/10.1007/978-3-7643-8550-7_220.
Testo completoBukowski, Ronald M., e Charles Tannenbaum. "Interleukin-12". In Melanoma, 221–34. Totowa, NJ: Humana Press, 2002. http://dx.doi.org/10.1007/978-1-59259-159-6_8.
Testo completoKaufman, Howard L., e Neal Dharmadhikari. "Interleukin-12". In Cancer Therapeutic Targets, 1–15. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6613-0_144-1.
Testo completoDieckman, Tessa, Antonie Zwiers, Georg Kraal e Gerd Bouma. "Interleukin 12". In Encyclopedia of Inflammatory Diseases, 1–7. Basel: Springer Basel, 2014. http://dx.doi.org/10.1007/978-3-0348-0620-6_220-1.
Testo completoBryan, Shannon, Michiko Kobayashi e Sanjiv Sur. "Interleukin-12, Interleukin-18 and Interferon-γ". In New Drugs for Asthma, Allergy and COPD, 274–78. Basel: KARGER, 2001. http://dx.doi.org/10.1159/000062155.
Testo completoPile, Kevin D., Garry G. Graham e Stephen M. Mahler. "Interleukin-12/23 Inhibitors: Ustekinumab". In Compendium of Inflammatory Diseases, 714–17. Basel: Springer Basel, 2016. http://dx.doi.org/10.1007/978-3-7643-8550-7_232.
Testo completoPile, Kevin D., Garry G. Graham e Stephen M. Mahler. "Interleukin-12/23 Inhibitors: Ustekinumab". In Encyclopedia of Inflammatory Diseases, 1–3. Basel: Springer Basel, 2015. http://dx.doi.org/10.1007/978-3-0348-0620-6_232-1.
Testo completoAulitzky, W. E., e C. Huber. "Interleukin-12: Biology and Clinical Studies". In Symposium in Immunology VI, 111–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60562-8_10.
Testo completoFernández-Ruiz, Mario. "Interleukin-12 and -23 Targeted Agents". In Infectious Complications in Biologic and Targeted Therapies, 199–217. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-11363-5_11.
Testo completoAtti di convegni sul tema "Interleukin-12"
"03 Targeting interleukin 12/23". In 8th ANNUAL MEETING OF THE LUPUS ACADEMY, Warsaw, Poland, September 6–8, 2019. Lupus Foundation of America, 2019. http://dx.doi.org/10.1136/lupus-2019-la.15.
Testo completoConway, R., L. O’Neill, P. Gallagher, G. McCarthy, C. Murphy, D. Veale, U. Fearon e E. Molloy. "SAT0542 Interleukin-12 and interleukin-23 are key pathogenic players in giant cell arteritis". In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.2850.
Testo completoCanataroglu, A., E. Erken e R. Gunesacar. "FRI0165 Serum levels of interleukin-12 in behcet’s disease". In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.225.
Testo completoVo, Jimmy Nhu. "Abstract 1535: Intratumoral chitosan/interleukin-12 immunotherapy reduces breast cancer metastasis". In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1535.
Testo completoUrsic Valentinuzzi, K., U. Kamensek, S. Kos, S. Kranjc Brezar, M. Cemazar e G. Sersa. "P08.03 Interleukin-12 gene electrotransfer as an adjuvant immunotherapy to electrochemotherapy". In iTOC9 – 9th Immunotherapy of Cancer Conference, September 22–24, 2022 – Munich, Germany. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-itoc9.49.
Testo completoIshihara, Jun, Aslan Mansurov e Jeffrey Hubbell. "1227 Eliminating the immunotoxicity of interleukin-12 through protease-sensitive masking". In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.1227.
Testo completoSmith, Sean, Jack Baltz, Bhanu Koppolu, Sruthi Ravindranathan, Khue Nguyen e David Zaharoff. "Abstract B020: Effector cells in chitosan/interleukin-12 immunotherapy of bladder tumors in mice". In Abstracts: CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr15-b020.
Testo completoYang, Xi, Ashlee Tietje, Xianzhong Yu e Yanzhang Wei. "Abstract 4874: Interleukin-12/FasTI: A novel bi-functional fusion protein for cancer immunotherapy". In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4874.
Testo completoCheema, Tooba A., Hiroaki Wakimoto, Samuel Rabkin e Robert L. Martuza. "Abstract 5389: Oncolytic herpes simplex virus expressing interleukin-12 for treating glioma stem cells". In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-5389.
Testo completoSimkin, Guillermo O., Julia G. Levy e David W. C. Hunt. "Interleukin-12 reverses the inhibitory impact of photodynamic therapy (PDT) on the murine contact hypersensitivity response". In BiOS '98 International Biomedical Optics Symposium, a cura di Thomas J. Dougherty. SPIE, 1998. http://dx.doi.org/10.1117/12.308134.
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