Letteratura scientifica selezionata sul tema "Integrative Conjugative Elements (ICEs)"
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Articoli di riviste sul tema "Integrative Conjugative Elements (ICEs)":
Bellanger, Xavier, Adam P. Roberts, Catherine Morel, Frédéric Choulet, Guillaume Pavlovic, Peter Mullany, Bernard Decaris e Gérard Guédon. "Conjugative Transfer of the Integrative Conjugative Elements ICESt1 and ICESt3 from Streptococcus thermophilus". Journal of Bacteriology 191, n. 8 (30 gennaio 2009): 2764–75. http://dx.doi.org/10.1128/jb.01412-08.
Zakharova, I. B., e D. V. Viktorov. "Integrative conjugative elements (ICEs) of microorganisms". Molecular Genetics, Microbiology and Virology 30, n. 3 (luglio 2015): 114–23. http://dx.doi.org/10.3103/s0891416815030076.
Iannelli, Francesco, Francesco Santoro, Marco R. Oggioni e Gianni Pozzi. "Nucleotide Sequence Analysis of Integrative Conjugative Element Tn5253of Streptococcus pneumoniae". Antimicrobial Agents and Chemotherapy 58, n. 2 (2 dicembre 2013): 1235–39. http://dx.doi.org/10.1128/aac.01764-13.
Bioteau, Audrey, Romain Durand e Vincent Burrus. "Redefinition and Unification of the SXT/R391 Family of Integrative and Conjugative Elements". Applied and Environmental Microbiology 84, n. 13 (13 aprile 2018): e00485-18. http://dx.doi.org/10.1128/aem.00485-18.
Libante, Virginie, Yves Nombre, Charles Coluzzi, Johan Staub, Gérard Guédon, Marcelo Gottschalk, Sarah Teatero, Nahuel Fittipaldi, Nathalie Leblond-Bourget e Sophie Payot. "Chromosomal Conjugative and Mobilizable Elements in Streptococcus suis: Major Actors in the Spreading of Antimicrobial Resistance and Bacteriocin Synthesis Genes". Pathogens 9, n. 1 (25 dicembre 2019): 22. http://dx.doi.org/10.3390/pathogens9010022.
Lei, Chang-Wei, An-Yun Zhang, Hong-Ning Wang, Bi-Hui Liu, Li-Qin Yang e Yong-Qiang Yang. "Characterization of SXT/R391 Integrative and Conjugative Elements in Proteus mirabilis Isolates from Food-Producing Animals in China". Antimicrobial Agents and Chemotherapy 60, n. 3 (11 gennaio 2016): 1935–38. http://dx.doi.org/10.1128/aac.02852-15.
Haskett, Timothy L., Jason J. Terpolilli, Amanuel Bekuma, Graham W. O’Hara, John T. Sullivan, Penghao Wang, Clive W. Ronson e Joshua P. Ramsay. "Assembly and transfer of tripartite integrative and conjugative genetic elements". Proceedings of the National Academy of Sciences 113, n. 43 (12 ottobre 2016): 12268–73. http://dx.doi.org/10.1073/pnas.1613358113.
Hirose, Jun. "Diversity and Evolution of Integrative and Conjugative Elements Involved in Bacterial Aromatic Compound Degradation and Their Utility in Environmental Remediation". Microorganisms 11, n. 2 (9 febbraio 2023): 438. http://dx.doi.org/10.3390/microorganisms11020438.
Dimopoulou, Ioanna D., Sofia I. Kartali, Rosalind M. Harding, Tim E. A. Peto e Derrick W. Crook. "Diversity of antibiotic resistance integrative and conjugative elements among haemophili". Journal of Medical Microbiology 56, n. 6 (1 giugno 2007): 838–46. http://dx.doi.org/10.1099/jmm.0.47125-0.
Iannelli, Francesco, Francesco Santoro, Valeria Fox e Gianni Pozzi. "A Mating Procedure for Genetic Transfer of Integrative and Conjugative Elements (ICEs) of Streptococci and Enterococci". Methods and Protocols 4, n. 3 (28 agosto 2021): 59. http://dx.doi.org/10.3390/mps4030059.
Tesi sul tema "Integrative Conjugative Elements (ICEs)":
Lao, Julie. "Conception et mise en oeuvre d’une approche bioinformatique dédiée à l’identification des ICE, IME et éléments composites dans les génomes de Firmicutes". Electronic Thesis or Diss., Université de Lorraine, 2021. http://www.theses.fr/2021LORR0063.
ICEs (Integrative Conjugative Elements) and IMEs (Integrative Mobilizable Elements) are bacterial mobile elements that play a key role in horizontal transfers. They have the capacity to integrate and transfer by conjugation from one bacterium to another. These elements are widespread in bacterial genomes but are still poorly understood. Their automatic identification is a challenge and they are generally not annotated in genomes. So far, only two bioinformatic approaches allow the detection of ICEs and IMEs, but their reliability remains highly variable, particularly among Firmicutes. Moreover, neither of these approaches can accurately detect composite elements consisting of nested or accreted ICEs and IMEs, which are frequently observed in bacterial genomes. We have developed a strategy and a tool called ICEscreen to identify ICEs and IMEs in the genomes of Firmicutes, including nested or accreted elements. Our tool starts with the detection of four signature proteins (SPs) that are essential to the functioning of these elements and then carries out the detection and typing of the elements based on the colocalization of the SPs and the characterisation of their content. Our tool uses a dedicated algorithm to solve the structure of the elements whether they are composite or not. To perform these steps, we have built a bank of ICEs and IMEs signature proteins from a list of genes known to be involved in the dynamics of these elements in streptococci and also public HMM profiles and HMM profiles constructed especially for this study. To validate the ICEscreen results, we built a dataset, FirmiData, consisting of 40 genomes of Firmicutes for which the ICEs and IMEs were annotated semi-manually and curated. We then compared the results of ICEscreen with those of two reference tools: CONJscan and ICEfinder. ICEscreen detects almost all the elements of the reference (96%) making it a more powerful tool than CONJscan (58%) and especially ICEfinder (53%) on our dataset. ICEscreen is thus a tool for the annotation and discovery of ICE and IME in the genomes of Firmicutes, which can help to better characterize their contribution to horizontal gene transfers, particularly during the transmission of antibiotic resistance, with which they are frequently associated
Coluzzi, Charles. "L'exploration des génomes par l'outil ICEFinder révèle la forte prévalence et l'extrême diversité des ICE et des IME de streptocoques". Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0352/document.
Mobile genetic elements largely contribute to the evolution and diversity of bacterial genomes through horizontal gene transfer. Among them, the integrative and conjugative elements (ICEs) encode their own excision, conjugative transfer and integration. On the other hand, integrative mobilizable elements (IMEs) are autonomous for excision and integration but encode only some of the proteins needed for their conjugative transfer. IMEs therefore need a “helper” conjugative element to transfer. Despite their impact on gene flow and genome dynamics, the prevalence of ICEs remains largely underscored and very few IMEs were identified at the beginning of this study. Furthermore, although several in silico methods exist to detect genomic islands, none are dedicated to ICEs or IMEs, thus complicating exhaustive examination of these mobile elements. The Streptococcus genus belongs to the firmicutes’ phylum. Almost all streptococci are commensal bacteria or pathogenes to men and animals. Two species of Streptococcus are also used in the dairy industry as lactic ferments in order to produce fermented milk and different types of cheese. Studying the gene flux of the Steptococci genus and the impact it can have on the lifestyle of these organisms is essential, as it has a lot of interest for human health and activities. In this work, we searched for ICEs and IMEs in 124 strains of streptococci belonging to 27 species using a reference database of ICE and IME signature proteins (from their conjugation, mobilization and integration/excision modules). This exhaustive analysis led to the identification and delimitation of 131 ICEs or slightly decayed ICEs and 144 IMEs. All these elements were delimited, which allowed us to identify their integration specificities in the genomes. In total, 17 ICE integration specificities were identified. Among them, 8 had never been described before (ftsK, guaA, lysS, mutT, rpmG, rpsI, traG and ybaB/EbfC). 18 specificities were also identified for IMEs, among which only 5 were known for the firmicutes. ICEs encode high or low-specificity tyrosine integrases (13 different specificities), single serine intégrases (1 specificity), triplet of serine integrases (3 different specificities), or DDE transposases while IMEs encode either tyrosine integrases (10 different specificities) or single serine integrases (8 different specificities). ICE were grouped in 7 distinct families according to the proteins encoded by their conjugation module whereas the mobilization modules of IMEs were highly diverse, preventing them from grouping into families according to their mobilization modules. The phylogenetic analysis of the signature proteins encoded by all ICEs and IMEs showed integration module exchanges between ICEs and IMEs and several mobilization module exchanges between IMEs. The overall results reveal a strong prevalence and extreme diversity of these elements among Streptococci genomes. Better understanding and knowledge of ICEs and IMEs prompted us to build a semi-automated command-line tool to identify streptococcal ICEs and IMEs as well as to determine their insertion site
Wright, Laurel D. "Autonomous replication of integrative and conjugative elements". Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/106738.
Cataloged from PDF version of thesis.
Includes bibliographical references.
Mobile genetic elements facilitate movement of genes, including those conferring antibiotic resistance and other traits, between bacteria. Integrative and conjugative elements (ICEs), also known as conjugative transposons, are a large family of mobile genetic elements that can transfer between neighboring cells. ICEs are found integrated in the chromosome of their host bacterium, where they are transmitted to daughter cells by chromosomal replication and cell division. Under certain conditions, ICE DNA will excise and form a circular plasmid-like intermediate. It was previously thought that ICEs were incapable of autonomous replication. However, my research, along with the work of others, shows that ICEs can replicate autonomously, and that many ICEs utilize a rolling circle replication mechanism. Plasmids and phages that use rolling circle replication encode a single strand origin (sso) that enhances priming of DNA synthesis. We identified a functional single strand origin, sso1, in the integrative and conjugative element ICEBs1 of Bacillus subtilis. Genetic analyses indicated that ICEBs1 uses sso1 and at least one other region for second strand DNA synthesis. Sso activity was important for autonomous, rolling circle replication of ICEBs1 in host cells, and for stable acquisition of the element in new host cells. I also showed that the broad-host range ICE Tn916 replicates autonomously by a rolling circle mechanism. Replication of Tn916 was dependent on the relaxase encoded by Tn916 orf20. The origin of transfer of Tn916, oriT(916), also functioned as an origin of replication. I found that the relaxase (Orf20) and the two putative helicase processivity factors (Orf22 and Orf23) encoded by Tn916 likely interact in a complex to facilitate replication. Lastly, I identified a functional single strand origin of replication (sso) in Tn916 that I predict primes second strand synthesis during rolling circle replication. The importance of autonomous replication by rolling circle in the ICE lifecycle and horizontal gene transfer processes is discussed.
by Laurel D. Wright.
Ph. D.
Nouvel, Laurent-Xavier. "Etude de la diversité génétique de Mycoplasma agalactiae : plasticité des génomes, mobilome et dynamique de surface". Thesis, Toulouse, INPT, 2009. http://www.theses.fr/2009INPT013A/document.
Mycoplasma agalactiae is responsible of contagious agalactia, a disease of small ruminants that is still difficult to control and is listed by the OIE. In order to evaluate the genetic diversity of this pathogen, 101 isolates were compared using three techniques (VNTR, RFLP, vpma repertoire). Results revealed a high genetic homogeneity with the PG2 type strain as representative. Some isolates however diverged such as the 5632 which was sequenced and analysed here. Whole comparative genomic and proteomic analyses of the 5632 and PG2 strains indicate that their genomic plasticity resides in important genes flux and in the presence of several mobile genetic elements (10% of the genome). These analyses also revealed that specific loci encoding repertoire of surface proteins are highly dynamic. For these minimal bacteria that lack a cell-wall, these events have most likely played a major role in their survival and adaptation to complex hosts
Haskett, Timothy L. "Discovery and characterisation of tripartite Integrative & Conjugative Elements". Thesis, Haskett, Timothy L. (2018) Discovery and characterisation of tripartite Integrative & Conjugative Elements. PhD thesis, Murdoch University, 2018. https://researchrepository.murdoch.edu.au/id/eprint/41086/.
Stagg, Georgina. "Creation and characterisation of genetically-marked Mesorhizobium integrative and conjugative elements". Thesis, Stagg, Georgina (2018) Creation and characterisation of genetically-marked Mesorhizobium integrative and conjugative elements. Honours thesis, Murdoch University, 2018. https://researchrepository.murdoch.edu.au/id/eprint/42888/.
Farzand, Robeena. "Occurrence and roles of two integrative and conjugative elements in Klebsiella pneumoniae". Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/40665.
fox, Valeria. "Mobile genetic elements carrying stress response systems, antibiotic resistance determinants, and catabolic pathways". Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1159250.
Laroussi, Haifa. "Étude des mécanismes moléculaires d'initiation du transfert conjugatif d'ICESt3, médiée par une relaxase MOBT chez la bactérie Gram+ Streptococcus thermophilus". Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0176.
Bacterial genomes evolve mainly through horizontal gene transfer. Bacterial conjugation is one of the major mechanisms for these transfers. Conjugation is mediated by integrative and conjugative elements (ICE). In addition to their transfer function, ICEs encode other functions that may provide an adaptive advantage to their host, such as resistance to antibiotics whose dissemination is a major public health issue. It is therefore necessary to understand how ICEs are transferred in order to limit their dissemination.The transfer of an ICE from a donor cell to a recipient cell requires its excision from the chromosome, its transfer from one cell to the other and then its integration into the genomes of the two partner cells. According to the literature, the initiation of ICE transfer is mediated by a nucleoprotein complex called relaxosome, whose key protein is the relaxase, a transesterase encoded by the element. The role of the relaxase is to perform a single-stranded cleavage on the DNA of the ICE at a conserved site, called nic. This cleavage releases a free 3'OH end, used as a primer to initiate rolling circle replication. The DNA-relaxase complex is then driven to the conjugation pore.During my PhD thesis, I studied ICESt3 from Streptococcus thermophilus which belongs to the ICESt3/Tn916/ICEBs1 superfamily, widespread among Firmicutes. These ICEs encode a non-canonical relaxase belonging to the MOBT family, which is related to the rolling circle replication initiators of the Rep_trans family. The general objective of my thesis was to elucidate the function of the RelSt3 relaxase in order to decipher the molecular mechanisms of initiation of conjugative transfer mediated by a MOBT relaxase.My work led to the identification of the RelSt3 binding site on ICESt3 origin of transfer (oriT). This site, called bind, is peculiar in that it is distant from the nic site, which is not the case for other relaxase families. RelSt3 possesses an HTH domain at its N-terminus. I have shown that this domain is required for the binding of RelSt3 to its bind site, and that it is important for its catalytic activity. Conjugation assays demonstrated that this HTH domain is crucial for the conjugative transfer of ICESt3. Structural predictions of the HTH domain in complex with DNA led to the identification of the interaction interface with the bind site, confirmed by mutagenesis. I also demonstrated that RelSt3 exhibits a nicking-closing activity and that it covalently binds to the 5' end of the cleaved strand, demonstrating that this enzyme participates in both initial and final steps of conjugation.In the literature, it has been shown that relaxases interact frequently with other accessory proteins, encoded by the ICE or by the host bacteria, participating in relaxosome formation. The second objective of my thesis was to identify RelSt3 partners. Comparisons with available data on ICEBs1 from Bacillus subtilis allowed to identify two candidate proteins, OrfL and OrfM, that may belong to the relaxosome of ICESt3, as well as a cellular helicase, PcrA , probably involved in the rolling circle replication. A characterization of these proteins was performed using biochemical and biophysical approaches. The interaction network between all of these proteins was established using in vitro approaches, as well as with the in vivo two-hybrid approach. These data provide a first insight into the components of the ICESt3 relaxasome. I also showed that OrfL and OrfM stimulate the catalytic activity of RelSt3 in vitro, and that they are both essential for ICESt3 conjugation.This work lead to a better understanding of the molecular mechanisms required during the conjugation of an ICE driven by a MOBT family relaxase
SPAGNOLETTI, MATTEO. "Comparative genomics of V. cholerae 7th pandemic strains. Analysis of integrative conjugative elements, genomic islands and prophages". Doctoral thesis, 2012. http://hdl.handle.net/11573/917386.
Capitoli di libri sul tema "Integrative Conjugative Elements (ICEs)":
Cury, Jean, Sophie S. Abby, Olivia Doppelt-Azeroual, Bertrand Néron e Eduardo P. C. Rocha. "Identifying Conjugative Plasmids and Integrative Conjugative Elements with CONJscan". In Horizontal Gene Transfer, 265–83. New York, NY: Springer US, 2019. http://dx.doi.org/10.1007/978-1-4939-9877-7_19.
Cunha, Violette Da, Romain Guérillot, Mathieu Brochet e Philippe Glaser. "Integrative and Conjugative Elements Encoding DDE Transposases". In Bacterial Integrative Mobile Genetic Elements, 250–60. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9780367813925-15.
Ciric, Lena, Azmiza Jasni, Lisbeth Elvira de Vries, Yvonne Agersø, Peter Mullany e Adam P. Roberts. "The Tn916/Tn1545 Family of Conjugative Transposons". In Bacterial Integrative Mobile Genetic Elements, 153–70. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9780367813925-9.
Garriss, Geneviéve, e Vincent Burrus. "Integrating Conjugative Elements of the SXT/R391 Family". In Bacterial Integrative Mobile Genetic Elements, 217–34. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9780367813925-13.
Salyers, Abigail A., Jeffrey F. Gardner e Nadja B. Shoemaker. "Excision and Transfer of Bacteroides Conjugative Integrated Elements". In Bacterial Integrative Mobile Genetic Elements, 235–49. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9780367813925-14.
Berkmen, Melanie B., Stephanie J. Laurer, Bridget K. Giarusso e Rodrigo Romero. "The Integrative and Conjugative Element ICEBs1 of Bacillus subtilis". In Bacterial Integrative Mobile Genetic Elements, 201–16. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9780367813925-12.
Esnault, Emilie, Alain Raynal e Jean-Luc Pernodet. "pSAM2, a Paradigm for a Family of Actinomycete Integrative and Conjugative Elements". In Bacterial Integrative Mobile Genetic Elements, 135–52. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9780367813925-8.
A., Minimol V., Pankaj Kishore e Mukteswar Prasad Mothadaka. "Evolution and the Role of SXT-Related Integrative Conjugative Elements in Multidrug-Resistant Vibrio cholerae". In Handbook on Antimicrobial Resistance, 1–17. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-16-9723-4_22-1.
Minimol, V. A., Pankaj Kishore e Mukteswar Prasad Mothadaka. "Evolution and the Role of SXT-Related Integrative Conjugative Elements in Multidrug-Resistant Vibrio cholerae". In Handbook on Antimicrobial Resistance, 465–81. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-9279-7_22.
Armshaw, Patricia, e J. Tony Pembroke. "UV Stress-Responsive Genes Associated with Enterobacterial Integrative Conjugative Elements of the ICE SXT/R391 Group". In Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, 517–27. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119004813.ch48.