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Letteratura scientifica selezionata sul tema "Instability mechanisms"

Autore: Grafiati

Pubblicato: 7 settembre 2024

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Articoli di riviste sul tema "Instability mechanisms"

1

Baird, D. M. "Mechanisms of telomeric instability". Cytogenetic and Genome Research 122, n. 3-4 (2008): 308–14. http://dx.doi.org/10.1159/000167817.

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Thompson, Sarah L., Samuel F. Bakhoum e Duane A. Compton. "Mechanisms of Chromosomal Instability". Current Biology 20, n. 6 (marzo 2010): R285—R295. http://dx.doi.org/10.1016/j.cub.2010.01.034.

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3

He Bai e M. Arcak. "Instability Mechanisms in Cooperative Control". IEEE Transactions on Automatic Control 55, n. 1 (gennaio 2010): 258–63. http://dx.doi.org/10.1109/tac.2009.2036301.

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4

Sharma, G., R. V. Ramanujan e G. P. Tiwari. "Instability mechanisms in lamellar microstructures". Acta Materialia 48, n. 4 (febbraio 2000): 875–89. http://dx.doi.org/10.1016/s1359-6454(99)00378-x.

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5

Venkatesan, Shriram, Adayapalam T. Natarajan e M. Prakash Hande. "Chromosomal instability—mechanisms and consequences". Mutation Research/Genetic Toxicology and Environmental Mutagenesis 793 (novembre 2015): 176–84. http://dx.doi.org/10.1016/j.mrgentox.2015.08.008.

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6

Gollin, Susanne M. "Mechanisms leading to chromosomal instability". Seminars in Cancer Biology 15, n. 1 (febbraio 2005): 33–42. http://dx.doi.org/10.1016/j.semcancer.2004.09.004.

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7

Shah, Prediman K. "Molecular mechanisms of plaque instability". Current Opinion in Lipidology 18, n. 5 (ottobre 2007): 492–99. http://dx.doi.org/10.1097/mol.0b013e3282efa326.

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8

Sirignano, William A. "Driving Mechanisms for Combustion Instability". Combustion Science and Technology 187, n. 1-2 (10 dicembre 2014): 162–205. http://dx.doi.org/10.1080/00102202.2014.973801.

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9

Gallaire, F., e J. M. Chomaz. "Instability mechanisms in swirling flows". Physics of Fluids 15, n. 9 (5 agosto 2003): 2622–39. http://dx.doi.org/10.1063/1.1589011.

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Huang, Jinhua, Jinping Liang, Lijia Huang e Tingting Li. "Mechanisms of Atherosclerotic Plaque Instability". International Journal of Biology and Life Sciences 5, n. 1 (22 febbraio 2024): 9–12. http://dx.doi.org/10.54097/83r6jq74.

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Abstract (sommario):

Cardiovascular disease (CVD) is the leading cause of mortality in humans worldwide. The main cause of CVD is the formation of thrombi due to by unstable atherosclerotic plaque rupture on the arterial wall. Long-term accumulation of thrombi results in vascular remodeling, and subsequent-stenosis of the lumen obstructs the blood flow, thereby leading to myocardial tissue ischemia and hypoxia. Sustained ischemia and hypoxia lead to myocyte necrosis, resulting in irreversible myocardial injury. Many molecular and cellular mechanisms are associated with atherosclerotic plaque instability (API). For example, macrophages can produce various inflammatory factors, adhesion factors, chemokines and matrix metalloproteinases (MMPs), which play important roles in the pathophysiological mechanisms of API and in maintaining plaque stability. These molecules may help predict unstable atherosclerotic plaques. If the plaque is stable, it will not be prone to rupture or thrombosis. Accordingly, in this review, we will discuss the different pathophysiological mechanisms of API and the related roles of macrophages in the mechanisms of API mainly in animal models and humans. We believe this review will provide a theoretical basis for the development of treatments and diagnostic approaches for the management of API.

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Tesi sul tema "Instability mechanisms"

1

Valkhoff, Nienke Jeltje Marjoke. "Stabilization by competing instability mechanisms". [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2006. http://dare.uva.nl/document/37776.

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Akl, Sherif Adel. "Wellbore instability mechanisms in clays". Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/64569.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, February 2011.
"February 2011." Cataloged from PDF version of thesis.
Includes bibliographical references (p. 331-341).
This dissertation investigates the stability of wellbores drilled in Ko-consolidated clays using non-linear finite element method (FEM) and effective stress soil models to characterize the behavior of clay and unconsolidated shale formations. Two constitutive models are used: Modified Cam Clay (MCC; Roscoe and Burland, 1968), and MIT-E3 (Whittle and Kavvadas, 1994). These soil models are incorporated in the commercial finite element program ABAQUS TM through user material subroutines (Hashash, 1992). The wellbores are modeled by a quasi-3D finite element model to approximate the far field stresses and plane strain boundary conditions. The constitutive models are calibrated to the behavior of Resedimented Boston Blue Clay (RBBC), an analog shale material which is Ko-consolidated to stress levels ranging from 0.15MPa to 10.0 MPa. The thesis comprises three major parts. Part one analyzes the short-term wellbore instability during drilling in low permeability formations. The part focuses on the relationship between the mud pressure inside the wellbore and the undrained shear deformations within the formations. The analyses predict critical mud pressure values necessary to maintain wellbore stability at different deviation angles and stress histories. The MIT-E3 model predicted higher deformations at reference mud pressure and estimated higher values of mud pressures than the underbalanced limit to prevent failure in highly deviated wellbores in NC clays. The second part validates the numerical analyses by comparing model predictions to results of an extensive program of model borehole tests. The lab experiments are performed on high pressure Thick- Walled Cylinder (TWC devices) using RBBC as analog testing material (Abdulhadi, 2009). The MIT-E3 predictions demonstrated a very good match with results from the experiments. The results from the analyses illustrated the effect of the device boundary conditions on specimen behavior and validated approximate analytical methods for interpreting TWC results. Part three studies the effects of consolidation on long-term wellbore stability. Non-linear coupled consolidation analyses are performed to simulate the post-drilling, time-dependent deformations and pore pressures around the wellbore. The analyses consider two different boundary conditions on seepage at the cavity. The analyses show that consolidation generates extensive volumetric strains around the wellbore and cavity deformations can aggravate stability conditions in highly deviated wellbores.
by Sherif Adel Akl.
Ph.D.

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3

Perkins, Adam Christopher. "Mechanisms of instability in Rayleigh-Bénard convection". Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42768.

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In many systems, instabilities can lead to time-dependent behavior, and instabilities can act as mechanisms for sustained chaos; an understanding of the dynamical modes governing instability is thus essential for prediction and/or control in such systems. In this thesis work, we have developed an approach toward characterizing instabilities quantitatively, from experiments on the prototypical Rayleigh-Bénard convection system. We developed an experimental technique for preparing a given convection pattern using rapid optical actuation of pressurized SF6, a greenhouse gas. Real-time analysis of convection patterns was developed as part of the implementation of closed-loop control of straight roll patterns. Feedback control of the patterns via actuation was used to guide patterns to various system instabilities. Controlled, spatially localized perturbations were applied to the prepared states, which were observed to excite the dominant system modes. We extracted the spatial structure and growth rates of these modes from analysis of the pattern evolutions. The lifetimes of excitations were also measured, near a particular instability; a critical wavenumber was found from the observed dynamical slowing near the bifurcation. We will also describe preliminary results of using a state estimation algorithm (LETKF) on experimentally prepared non-periodic patterns in a cylindrical convection cell.

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Thirthagiri, Eswary. "Mechanisms of genomic instability in oral cancer". Thesis, University of Bristol, 2005. http://hdl.handle.net/1983/dc1b9061-be5b-4839-a266-de82fd1da5cf.

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Hackett, Jennifer. "Telomere dysfunction and mechanisms of genomic instability". Available to US Hopkins community, 2003. http://wwwlib.umi.com/dissertations/dlnow/3080673.

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6

Chan, Kara Y. "MECHANISMS OF TRINUCLEOTIDE REPEAT INSTABILITY DURING DNA SYNTHESIS". UKnowledge, 2019. https://uknowledge.uky.edu/toxicology_etds/29.

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Genomic instability, in the form of gene mutations, insertions/deletions, and gene amplifications, is one of the hallmarks in many types of cancers and other inheritable genetic disorders. Trinucleotide repeat (TNR) disorders, such as Huntington’s disease (HD) and Myotonic dystrophy (DM) can be inherited and repeats may be extended through subsequent generations. However, it is not clear how the CAG repeats expand through generations in HD. Two possible repeat expansion mechanisms include: 1) polymerase mediated repeat extension; 2) persistent TNR hairpin structure formation persisting in the genome resulting in expansion after subsequent cell division. Recent in vitro studies suggested that a family A translesion polymerase, polymerase θ (Polθ), was able to synthesize DNA larger than the template DNA. Clinical and in vivo studies showed either overexpression or knock down of Polθ caused poor survival in breast cancer patients and genomic instability. However, the role of Polθ in TNR expansion remains unelucidated. Therefore, we hypothesize that Polθ can directly cause TNR expansion during DNA synthesis. The investigation of the functional properties of Polθ during DNA replication and TNR synthesis will provide insight for the mechanism of TNR expansion through generations.

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Lieuwen, Tim C. "Investigation of combustion instability mechanisms in premixed gas turbines". Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/20300.

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Ozols, Agris. "Low-dose studies of genomic instability-mechanisms and targets". Thesis, Queen Mary, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271260.

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Lee, A. J. X. "An investigation of chromosomal instability survival mechanisms in cancer". Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1344056/.

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Chromosomal instability (CIN) describes ongoing numerical and structural chromosomal aberrations in cancer cells, leading to intra-tumour heterogeneity and is frequently associated with polyploidy and aneuploidy. CIN is a frequent event in solid tumours and previous evidence has implicated CIN with acquired multidrug resistance, intrinsic taxane resistance and poor patient prognosis. In this thesis, I have attempted to explore mechanisms required for the initiation of CIN and the tolerance of this pattern of genome instability. Firstly, I have attempted to identify clinically relevant therapeutics that may have specific activity in CIN+ tumour cell lines. Focusing on a panel of colorectal cancer cell lines, classified as either CIN+ or CIN-, and treating them individually with kinase inhibitor and cytotoxic agent libraries, I demonstrated that CIN+ cell lines displayed significant intrinsic multidrug resistance. Next, I addressed if specific means to target CIN+ cells could be identified through pharmacological and RNA interference (RNAi) screens. No compounds were observed to be preferentially cytotoxic towards CIN+ cells in the pharmacological screen. A whole genome RNAi screen was performed to identify CIN+ specific survival pathways using isogenic cell line models of CIN. No genes were identified that conferred preferential cell death when silenced in CIN+ cells, despite sufficient statistical power to detect such targets. Using integrative genomics techniques and cell cycle data from this RNAi screen, I endeavoured to identify clinically relevant initiators of aneuploidy in colorectal cancer, that revealed both known and potential novel regulators of polyploidy. Finally, I endeavoured to identify a mechanistic basis for the taxane-sensitising phenotype associated with the silencing of the ceramide transporter, CERT, which may reveal means to target CIN+ cells. I demonstrated that CERT silencing sensitises paclitaxel-treated cells to cell death in a LAMP2-dependent manner that is associated with autophagy flux and may target death of multinucleated cells specifically.

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Barsoum, Nader N. "Analysis and computation of instability mechanisms in rotating electrical machinery". Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328149.

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Libri sul tema "Instability mechanisms"

1

United States. National Aeronautics and Space Administration, a cura di. Jet fuel instability mechanisms. [Washington, DC: National Aeronautics and Space Administration, 1985.

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2

European Environmental Mutagen Society. Meeting. Workshop on chromosome instability and cell cycle control: Istituto Superiore di Sanità, Rome, September 3-7, 1996 : abstract book. Roma: L'Istituto, 1996.

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3

François, Malburet, a cura di. Mechanical instability. London, UK: ISTE, 2011.

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4

Erickson, Gary M. A mechanism for magnetospheric substorms. [Washington, D.C: National Aeronautics and Space Administration, 1994.

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5

Hall, Philip. Instability of time-periodic flows. Hampton, Va: [Institute for Computer Applications in Science and Engineering], National Aeronautics and Space Administration, Langley Research Center, 1985.

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Hall, Philip. Instability of time-periodic flows. Hampton, Va: [Institute for Computer Applications in Science and Engineering], National Aeronautics and Space Administration, Langley Research Center, 1985.

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Hussaini, M. Y. Instability, Transition, and Turbulence. New York, NY: Springer New York, 1992.

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8

Hall, Philip. On the Gortler vortex instability mechanism at hypersonic speeds. Hampton, Va: ICASE, 1989.

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Hall, Philip. On the Goertler vortex instability mechanism at hypersonic speeds. Hampton, Va: National Aeronautics and Space Administration, Langley Research Center, 1989.

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Liou, William W. Linear instability of curved free shear layers. [Washington, DC: National Aeronautics and Space Administration, 1993.

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Capitoli di libri sul tema "Instability mechanisms"

1

Meng, Fanbiao, Baohua Liu e Zhongjun Zhou. "Progeria and Genome Instability". In Aging Mechanisms, 51–63. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55763-0_3.

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Cutsem, Thierry, e Costas Vournas. "Instability Mechanisms and Countermeasures". In Voltage Stability of Electric Power Systems, 263–98. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-0-387-75536-6_8.

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Koga, Hideyuki, Takeshi Muneta, Roald Bahr, Lars Engebretsen e Tron Krosshaug. "ACL Injury Mechanisms: Lessons Learned from Video Analysis". In Rotatory Knee Instability, 27–36. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-32070-0_3.

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Parniewski, Pawel, e Pawel Staczek. "Molecular Mechanisms of TRS Instability". In Triple Repeat Diseases of the Nervous Systems, 1–25. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0117-6_1.

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Wells, Robert D., Albino Bacolla e Richard P. Bowater. "Instabilities of Triplet Repeats: Factors and Mechanisms". In Trinucleotide Diseases and Instability, 133–65. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-540-69680-3_4.

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Coppola, Luigi. "Landslides Types and Their Failure Mechanisms". In Hydrogeological Instability in Cohesive Soils, 225–59. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-74331-8_7.

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Peters, Nils, Martin Dichgans, Sankar Surendran, Josep M. Argilés, Francisco J. López-Soriano, Sílvia Busquets, Klaus Dittmann et al. "Chromosome Instability Facial Anomalies". In Encyclopedia of Molecular Mechanisms of Disease, 354. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8928.

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Belyaev, A. K. "Example of Instability in Drive Mechanisms". In Advanced Dynamics and Model-Based Control of Structures and Machines, 35–42. Vienna: Springer Vienna, 2011. http://dx.doi.org/10.1007/978-3-7091-0797-3_5.

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Ryutova, Margarita. "Explosive Instability in Solar Coronal Loops". In Mechanisms of Chromospheric and Coronal Heating, 159–61. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-87455-0_34.

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Barrey, Cédric, Mehdi Afathi, Théo Broussolle, Corentin Dauleac e Philippe Bancel. "Craniovertebral Junction Instability and Mechanisms of Injury". In Surgery of the Cranio-Vertebral Junction, 291–305. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-18700-2_19.

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Atti di convegni sul tema "Instability mechanisms"

1

Bai, He, e Murat Arcak. "Instability mechanisms in cooperative control". In 2008 47th IEEE Conference on Decision and Control. IEEE, 2008. http://dx.doi.org/10.1109/cdc.2008.4738887.

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2

"Shear coaxial injector instability mechanisms". In 30th Joint Propulsion Conference and Exhibit. Reston, Virigina: American Institute of Aeronautics and Astronautics, 1994. http://dx.doi.org/10.2514/6.1994-2774.

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HEGDE, U., D. REUTER e B. ZINN. "Combustion instability mechanisms in ramjets". In 26th Aerospace Sciences Meeting. Reston, Virigina: American Institute of Aeronautics and Astronautics, 1988. http://dx.doi.org/10.2514/6.1988-150.

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4

Daouadji, A., H. Al Gali e F. Darve. "Triggering mechanisms of soil instability". In DEBRIS FLOW 2006. Southampton, UK: WIT Press, 2006. http://dx.doi.org/10.2495/deb060261.

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Sandberg, Richard, e Hermann Fasel. "Instability Mechanisms in Supersonic Base Flows". In 42nd AIAA Aerospace Sciences Meeting and Exhibit. Reston, Virigina: American Institute of Aeronautics and Astronautics, 2004. http://dx.doi.org/10.2514/6.2004-593.

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Klompas, Nicholas. "Predicting Engine Whirl Instability Via Equivalent 2D Mechanisms". In ASME Turbo Expo 2002: Power for Land, Sea, and Air. ASMEDC, 2002. http://dx.doi.org/10.1115/gt2002-30422.

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Analysis to predict whirl instability of a whole engine, including flexible bladed disks, due to both linear and nonlinear destabilizing mechanisms at any speed, not only the critical, is advanced. The basis is the previously published, and now extended, equivalent two-dimensional mechanism (E2dM). Proven through physical logic are the principles: (1) a deflection or slope with a phase angle greater than 90 deg lead in response to an external disturbing force or moment respectively signals instability; (2) response of a system absorbing energy is modulated at speeds below onset of instability. Tactics to exploit these principles through fundamental analyses of response are devised.

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NG, LIAN, e THOMAS ZANG. "Secondary instability mechanisms in compressible, axisymmetric boundary layers". In 30th Aerospace Sciences Meeting and Exhibit. Reston, Virigina: American Institute of Aeronautics and Astronautics, 1992. http://dx.doi.org/10.2514/6.1992-743.

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Shipley, Kevin J., William E. Anderson, Matthew E. Harvazinski e Venkateswaran Sankaran. "A Computational Study of Transverse Combustion Instability Mechanisms". In 50th AIAA/ASME/SAE/ASEE Joint Propulsion Conference. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2014. http://dx.doi.org/10.2514/6.2014-3680.

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Mukaiyama, Kenji, e Kazunori Kuwana. "Influence of Flame Front Instability on Flame Propagation Behavior". In ASME/JSME 2011 8th Thermal Engineering Joint Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/ajtec2011-44223.

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This paper discusses flame acceleration due to flame instability mechanisms. In particular, the diffusive-thermal instability and hydrodynamic instability mechanisms are considered. The Sivashinsky equation is used to compute two-dimensional flame propagation behaviors, and the influence of each instability mechanism is separately considered. The effect of flame size on flame speed (accelerated due to the instability mechanisms) is particularly investigated. It is found that the flame propagation velocity (Vf) is independent of flame size under the influence of diffusive-thermal instability, whereas Vf increases with flame size under the influence of hydrodynamic instability. The fractal nature of the flame under the influence of hydrodynamic instability is confirmed based on the dependence of Vf on flame size. Fractal dimension is then calculated as a function of volume expansion ratio, the parameter that controls the hydrodynamic instability mechanism. An FFT analysis is conducted to further understand the flame’s fractal structure.

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Cheredov, Alexander I., e Andrey V. Shchelkanov. "Displacement sensors with frequency output based on helical instability". In 2014 Dynamics of Systems, Mechanisms and Machines (Dynamics). IEEE, 2014. http://dx.doi.org/10.1109/dynamics.2014.7005645.

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Rapporti di organizzazioni sul tema "Instability mechanisms"

1

Forest, Greg, e Stephen Bechtel. Modeling of Free Viscoelastic Jets and Instability Mechanisms. Fort Belvoir, VA: Defense Technical Information Center, marzo 1990. http://dx.doi.org/10.21236/ada221672.

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Shipley, Kevin J., William E. Anderson, Matthew E. Harvazinski e Venkateswaran Sankaran. A Computational Study of Transverse Combustion Instability Mechanisms. Fort Belvoir, VA: Defense Technical Information Center, luglio 2014. http://dx.doi.org/10.21236/ada615844.

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Dynan, William S. Final Technical Report - Mechanisms and pathways controlling genomic instability. Office of Scientific and Technical Information (OSTI), maggio 2013. http://dx.doi.org/10.2172/1081424.

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Engelward, Bevin P. Mechanisms of Low Dose Radio-Suppression of Genomic Instability. Office of Scientific and Technical Information (OSTI), settembre 2009. http://dx.doi.org/10.2172/963997.

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Nussenzweig, Andre. Molecular Mechanisms Underlying Genomic Instability in Brca-Deficient Cells. Fort Belvoir, VA: Defense Technical Information Center, marzo 2012. http://dx.doi.org/10.21236/ada579479.

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Nussenzweig, Andre. Molecular Mechanisms Underlying Genomic Instability in Brca-Deficient Cells. Fort Belvoir, VA: Defense Technical Information Center, marzo 2013. http://dx.doi.org/10.21236/ada583192.

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Nussenzweig, Andre. Molecular Mechanisms Underlying Genomic Instability in Brca-Deficient Cells. Fort Belvoir, VA: Defense Technical Information Center, marzo 2014. http://dx.doi.org/10.21236/ada601775.

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Howard L. Liber e Jeffrey L. Schwartz. Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells. Office of Scientific and Technical Information (OSTI), ottobre 2005. http://dx.doi.org/10.2172/887495.

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Liber, Howard L. Molecular mechanisms of radiation-induced genomic instability in human cells. Office of Scientific and Technical Information (OSTI), febbraio 2003. http://dx.doi.org/10.2172/811204.

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10

Barry D. Michael, Kathryn Held e Kevin Prise. Low Dose Studies with Focused X-rays in Cell and Tissue Models: Mechanisms of Bystander and Genomic Instability Responses. Office of Scientific and Technical Information (OSTI), dicembre 2002. http://dx.doi.org/10.2172/806813.

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