Articoli di riviste sul tema "IDO/TDO"
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Oweira, Hani, Imad Lahdou, Stefan Mehrle, Elias Khajeh, Rajan Nikbakhsh, Omid Ghamarnejad, Peter Terness, Christoph Reißfelder, Mahmoud Sadeghi e Ali Ramouz. "Kynurenine Is the Main Metabolite of Tryptophan Degradation by Tryptophan 2,3-Dioxygenase in HepG2 Tumor Cells". Journal of Clinical Medicine 11, n. 16 (16 agosto 2022): 4794. http://dx.doi.org/10.3390/jcm11164794.
Testo completoTerai, Londin, Rochani, Link, Lam, Kaushal, Bhushan, Orloff e Sato. "Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma". Cancers 12, n. 2 (10 febbraio 2020): 405. http://dx.doi.org/10.3390/cancers12020405.
Testo completoKim, Chan, Joo Hoon Kim, Jin Sung Kim, Hong Jae Chon e Joo-Hang Kim. "A novel dual inhibitor of IDO and TDO, CMG017, potently suppresses the kynurenine pathway and overcomes resistance to immune checkpoint inhibitors." Journal of Clinical Oncology 37, n. 15_suppl (20 maggio 2019): e14228-e14228. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e14228.
Testo completoCampesato, Luis Felipe, Sadna Budhu, Jeremy Tchaicha, Abhinav Jaiswal, Mathieu Gigoux, Stephane Pourpe, Cailian Liu et al. "Blockade of IDO/TDO downstream effectors restricts cancer immune suppression". Journal of Immunology 202, n. 1_Supplement (1 maggio 2019): 137.3. http://dx.doi.org/10.4049/jimmunol.202.supp.137.3.
Testo completoThackray, Sarah J., Christopher G. Mowat e Stephen K. Chapman. "Exploring the mechanism of tryptophan 2,3-dioxygenase". Biochemical Society Transactions 36, n. 6 (19 novembre 2008): 1120–23. http://dx.doi.org/10.1042/bst0361120.
Testo completoOxenkrug, G. "Genetic and Environmental Impacts in Major Depressive Disorder are Mediated Via Kynurenine Pathway of Tryptophan Metabolism". European Psychiatry 24, S1 (gennaio 2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70899-5.
Testo completoSUZUKI, Sachiko, Shigenobu TONÉ, Osamu TAKIKAWA, Toshikazu KUBO, Ichiro KOHNO e Yohsuke MINATOGAWA. "Expression of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase in early concepti". Biochemical Journal 355, n. 2 (6 aprile 2001): 425–29. http://dx.doi.org/10.1042/bj3550425.
Testo completoNienhaus, Karin, e G. Ulrich Nienhaus. "Co Recombination in Human IDO and TDO - A Comparison". Biophysical Journal 106, n. 2 (gennaio 2014): 676a. http://dx.doi.org/10.1016/j.bpj.2013.11.3744.
Testo completoSacramento, Jireh Joy D., e David P. Goldberg. "Oxidation of an indole substrate by porphyrin iron(iii) superoxide: relevance to indoleamine and tryptophan 2,3-dioxygenases". Chemical Communications 56, n. 20 (2020): 3089–92. http://dx.doi.org/10.1039/c9cc10019a.
Testo completoPaccosi, Sara, Marta Cecchi, Angela Silvano, Sergio Fabbri e Astrid Parenti. "Different effects of tryptophan 2,3-dioxygenase inhibition on SK-Mel-28 and HCT-8 cancer cell lines". Journal of Cancer Research and Clinical Oncology 146, n. 12 (10 agosto 2020): 3155–63. http://dx.doi.org/10.1007/s00432-020-03351-2.
Testo completoFunakoshi, Hiroshi, Masaaki Kanai e Toshikazu Nakamura. "Modulation of Tryptophan Metabolism, Promotion of Neurogenesis and Alteration of Anxiety-Related Behavior in Tryptophan 2,3-Dioxygenase-Deficient Mice". International Journal of Tryptophan Research 4 (gennaio 2011): IJTR.S5783. http://dx.doi.org/10.4137/ijtr.s5783.
Testo completoBadawy, Abdulla A.-B. "Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects". International Journal of Tryptophan Research 10 (1 gennaio 2017): 117864691769193. http://dx.doi.org/10.1177/1178646917691938.
Testo completoYoshioka, Saeko, Tomonori Ikeda, Sogo Fukuchi, Yurika Kawai, Katsumi Ohta, Hisashi Murakami, Naohisa Ogo, Daisuke Muraoka, Osamu Takikawa e Akira Asai. "Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase". International Journal of Tryptophan Research 15 (gennaio 2022): 117864692211384. http://dx.doi.org/10.1177/11786469221138456.
Testo completoBadawy, Abdulla A.-B., e Gilles J. Guillemin. "Species Differences in Tryptophan Metabolism and Disposition". International Journal of Tryptophan Research 15 (gennaio 2022): 117864692211225. http://dx.doi.org/10.1177/11786469221122511.
Testo completoYeh, Syun-Ru, Ariel Lewis-Ballester e Shay Karkashon. "Comparative Studies of Human Indoleamine 2,3-Dioxygenase (IDO) and Tryptophan Dioxygenase (TDO)". Biophysical Journal 102, n. 3 (gennaio 2012): 467a. http://dx.doi.org/10.1016/j.bpj.2011.11.2560.
Testo completoTakkenkamp, Tim J., Mathilde Jalving, Frederik J. H. Hoogwater e Annemiek M. E. Walenkamp. "The immune tumour microenvironment of neuroendocrine tumours and its implications for immune checkpoint inhibitors". Endocrine-Related Cancer 27, n. 9 (settembre 2020): R329—R343. http://dx.doi.org/10.1530/erc-20-0113.
Testo completoLuques, Lisandro, Ashby Kissoondoyal, Emily De Sousa, Paula Quaglietta, David Malkin, Stefano Cairo, Emilie Indersie e Reto Baertschiger. "Abstract 3539: Indoleamine-2,3-dioxygenase 2 (IDO-2) is expressed in hepatoblastoma cells and associated with metastatic state". Cancer Research 83, n. 7_Supplement (4 aprile 2023): 3539. http://dx.doi.org/10.1158/1538-7445.am2023-3539.
Testo completoQin, Yanjie, Nanxi Wang, Xinlin Zhang, Xuemei Han, Xuejia Zhai e Yongning Lu. "IDO and TDO as a potential therapeutic target in different types of depression". Metabolic Brain Disease 33, n. 6 (16 luglio 2018): 1787–800. http://dx.doi.org/10.1007/s11011-018-0290-7.
Testo completoMuzik, O., F. John, S. Mittal e C. Juhasz. "P11.35 Fluorine-18-labeled PET radiotracers for imaging tryptophan uptake and metabolism in brain tumors". Neuro-Oncology 21, Supplement_3 (agosto 2019): iii50—iii51. http://dx.doi.org/10.1093/neuonc/noz126.181.
Testo completoYe, Zixiang, Linxiu Yue, Jiachen Shi, Mingmei Shao e Tao Wu. "Role of IDO and TDO in Cancers and Related Diseases and the Therapeutic Implications". Journal of Cancer 10, n. 12 (2019): 2771–82. http://dx.doi.org/10.7150/jca.31727.
Testo completoJovanovic, Filip, Kenneth D. Candido e Nebojsa Nick Knezevic. "The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents". International Journal of Molecular Sciences 21, n. 17 (22 agosto 2020): 6045. http://dx.doi.org/10.3390/ijms21176045.
Testo completoNaismith, James H. "Tryptophan oxygenation: mechanistic considerations". Biochemical Society Transactions 40, n. 3 (22 maggio 2012): 509–14. http://dx.doi.org/10.1042/bst20120073.
Testo completoAshoura, Norah E., Joseph D. Dekker, Todd Triplett, Kendra Garrison, John Blazeck, Christos Karamitros, Candice Lamb et al. "The Force Awakens: Illuminating the role of kynurenine in cancer progression and treatment." Journal of Immunology 200, n. 1_Supplement (1 maggio 2018): 177.3. http://dx.doi.org/10.4049/jimmunol.200.supp.177.3.
Testo completoRafice, Sara A., Nishma Chauhan, Igor Efimov, Jaswir Basran e Emma Lloyd Raven. "Oxidation of L-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase". Biochemical Society Transactions 37, n. 2 (20 marzo 2009): 408–12. http://dx.doi.org/10.1042/bst0370408.
Testo completoBadawy, Abdulla A.-B., e Gilles Guillemin. "The Plasma [Kynurenine]/[Tryptophan] Ratio and Indoleamine 2,3-Dioxygenase: Time for Appraisal". International Journal of Tryptophan Research 12 (gennaio 2019): 117864691986897. http://dx.doi.org/10.1177/1178646919868978.
Testo completoOh, Angela. "Crystallization of heme dioxygenases IDO and TDO facilitates structure-based design of cancer immunology therapeutics". Acta Crystallographica Section A Foundations and Advances 76, a1 (2 agosto 2020): a45. http://dx.doi.org/10.1107/s0108767320099547.
Testo completoCampesato, Luis Felipe, Sadna Budhu, Jeremy Tchaicha, Stephane Pourpe, Cailian Liu, Mark G. Manfredi, Karen McGovern, Jedd D. Wolchok e Taha Merghoub. "Interaction between Kynurenine and the AhR is an effector mechanism of tumor immunosuppression and represents a potential immunotherapy target". Journal of Immunology 200, n. 1_Supplement (1 maggio 2018): 177.5. http://dx.doi.org/10.4049/jimmunol.200.supp.177.5.
Testo completoAlan, Wise, Mcguinness E. Barry, Cowley M. Phillip, Trewick C. Sarah, Bevan Nicola, Szybut Clare e Brown J. Thomas. "ITOC2 – 013. In vitro kynurenine modulation by novel dual-acting and selective TDO and IDO inhibitors". European Journal of Cancer 51 (marzo 2015): S5. http://dx.doi.org/10.1016/j.ejca.2015.01.026.
Testo completoYuasa, Hajime J., e Helen J. Ball. "Efficient tryptophan-catabolizing activity is consistently conserved through evolution of TDO enzymes, but not IDO enzymes". Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 324, n. 2 (20 febbraio 2015): 128–40. http://dx.doi.org/10.1002/jez.b.22608.
Testo completoBadawy, Abdulla A. B., Aryan M. A. Namboodiri e John R. Moffett. "The end of the road for the tryptophan depletion concept in pregnancy and infection". Clinical Science 130, n. 15 (29 giugno 2016): 1327–33. http://dx.doi.org/10.1042/cs20160153.
Testo completoEl-Zahabi, Mohamed Ayman ALy, Mostafa Youssef Abouzeid, Ibrahim H. Eissa e Mohamed S. Taghour. "DUAL INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE (IDO) AND TRYPTOPHAN-2,3-DIOXYGENASE (TDO) AS ANTI-TUMOR IMMUNE MODULATORS". Al-Azhar Journal of Pharmaceutical Sciences 69, n. 1 (1 marzo 2024): 38–61. http://dx.doi.org/10.21608/ajps.2024.360357.
Testo completoKim, C., N. K. Lee, J. S. Kim, W. R. Kim, D. H. Kim, D. J. Kim, J. S. Oh, S. K. Chang, J. W. Kim e H. J. Chon. "An oral dual inhibitor of IDO and TDO enhances anti-cancer immunity and synergizes with immune checkpoint blockade". Annals of Oncology 29 (ottobre 2018): viii416. http://dx.doi.org/10.1093/annonc/mdy288.039.
Testo completoLiu, Xiangdong, Niu Shin, Holly K. Koblish, Gengjie Yang, Qian Wang, Kathy Wang, Lynn Leffet et al. "Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity". Blood 115, n. 17 (29 aprile 2010): 3520–30. http://dx.doi.org/10.1182/blood-2009-09-246124.
Testo completoBrincks, Erik L., James Adams, Lifu Wang, Benjamin Turner, Agnieszka Marcinowicz, Jiyuan Ke, Michael Essmann et al. "Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1". Oncotarget 11, n. 25 (23 giugno 2020): 2438–61. http://dx.doi.org/10.18632/oncotarget.27646.
Testo completoBerthon, Céline, Michaela Fontenay, Selim Corm, Isabelle Briche, Michel Lhermitte e Bruno Quesnel. "Metabolites of Tryptophan Catabolism Are Elevated in Sera of Patients with Myelodysplastic Syndromes and Inhibit Hematopoietic Progenitor Amplification". Blood 120, n. 21 (16 novembre 2012): 3843. http://dx.doi.org/10.1182/blood.v120.21.3843.3843.
Testo completoPetrovic, Vladimir, Jamie Wong, Cedric E. Dos Santos, Richard Smith, Dan Fitzpatrick, Robert Loberg e Ariel Avilion. "IDO Pathway Analysis for Identifying Novel Biomarkers in Multiple Myeloma". Blood 132, Supplement 1 (29 novembre 2018): 5572. http://dx.doi.org/10.1182/blood-2018-99-111392.
Testo completoBooth, Nicholas, Wells Brockbank, Samuel Oh e Karl Kingsley. "Indoleamine 2,3-dioxygenase (IDO) and tryptophan dioxygenase (TDO) mRNA expression in oral squamous cell carcinoma cells is actively and differentially modulated". Journal of Molecular Pathophysiology 1, n. 1 (2012): 29. http://dx.doi.org/10.5455/jmp.20120609040915.
Testo completoChen, Xiangli, Yuzhu Zang, Dujuan Li, Jianmin Guo, Yacai Wang, Yuqi Lin e Zhenghong Wei. "IDO, TDO, and AHR overexpression is associated with poor outcome in diffuse large B-cell lymphoma patients in the rituximab era". Medicine 99, n. 21 (22 maggio 2020): e19883. http://dx.doi.org/10.1097/md.0000000000019883.
Testo completoStone, Trevor W., e Richard O. Williams. "Interactions of IDO and the Kynurenine Pathway with Cell Transduction Systems and Metabolism at the Inflammation–Cancer Interface". Cancers 15, n. 11 (24 maggio 2023): 2895. http://dx.doi.org/10.3390/cancers15112895.
Testo completoJovanovic, Filip, Aboorva Sudhakar e Nebojsa Nick Knezevic. "The Kynurenine Pathway and Polycystic Ovary Syndrome: Inflammation as a Common Denominator". International Journal of Tryptophan Research 15 (gennaio 2022): 117864692210992. http://dx.doi.org/10.1177/11786469221099214.
Testo completoNoakes, Rowland R. "Effects of Tranilast on the Urinary Excretion of Kynurenic and Quinolinic Acid under Conditions of L Tryptophan Loading". International Journal of Tryptophan Research 6 (gennaio 2013): IJTR.S12797. http://dx.doi.org/10.4137/ijtr.s12797.
Testo completoKubacka, Justyna, Anna Stefańska e Grażyna Sypniewska. "Kynurenine pathway: the link between depressive disorders and inflammation". Postępy Higieny i Medycyny Doświadczalnej 74 (6 agosto 2020): 331–39. http://dx.doi.org/10.5604/01.3001.0014.3454.
Testo completoSpector, Sydney, Chunjing Wu, Dan Nguyen, George Theodore, Ashley Garcia, Lynn Feun, Niramol Savaraj e Medhi Wangpaichitr. "Abstract 2325: Targeting kynurenine pathway using novel IDO/TDO dual inhibitor (AT0174) to modulate tumor microenvironment in platinum resistant non-small cell lung cancer cancer: An immunometabolism compliment markers". Cancer Research 82, n. 12_Supplement (15 giugno 2022): 2325. http://dx.doi.org/10.1158/1538-7445.am2022-2325.
Testo completoPal, Anasua, Philipp Zimmer, Dorothea Clauss, Martina E. Schmidt, Cornelia M. Ulrich, Joachim Wiskemann e Karen Steindorf. "Resistance Exercise Modulates Kynurenine Pathway in Pancreatic Cancer Patients". International Journal of Sports Medicine 42, n. 01 (24 luglio 2020): 33–40. http://dx.doi.org/10.1055/a-1186-1009.
Testo completoGiannakis, Marios, Haoxin Li, Chelsea Jin, Shuba Gopal, Kaushal Desai, Christine Horak, Megan Wind-Rotolo et al. "Metabolomic correlates of response in nivolumab-treated renal cell carcinoma and melanoma patients." Journal of Clinical Oncology 35, n. 15_suppl (20 maggio 2017): 3036. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.3036.
Testo completoPires, Ananda Staats, Shabarni Gupta, Sean A. Barton, Roshana Vander Wall, Vanessa Tan, Benjamin Heng, Jacqueline K. Phillips e Gilles J. Guillemin. "Temporal Profile of Kynurenine Pathway Metabolites in a Rodent Model of Autosomal Recessive Polycystic Kidney Disease". International Journal of Tryptophan Research 15 (gennaio 2022): 117864692211260. http://dx.doi.org/10.1177/11786469221126063.
Testo completoPapadopoulos, Kyriakos, Michael Cecchini, Juanita S. Lopez, Dirk Jäger, Ki Young Chung, Michael Platten, Florian Prinz et al. "Abstract CT276: Preliminary analysis of pharmacokinetic (PK) and target engagement biomarkers from a first in human phase 1 study of immunomodulatory aryl hydrocarbon receptor (AhR) inhibitor BAY2416964". Cancer Research 83, n. 8_Supplement (14 aprile 2023): CT276. http://dx.doi.org/10.1158/1538-7445.am2023-ct276.
Testo completoDawood, Shazia, Samina Bano e Abdulla Abu-Bakr Badawy. "Inflammation and serotonin deficiency in major depressive disorder: Molecular docking of antidepressant and antiinflammatory drugs to tryptophan and indoleamine 2,3-dioxygenases". Bioscience Reports, 4 maggio 2022. http://dx.doi.org/10.1042/bsr20220426.
Testo completoGualdoni, Gisela S., Patricia V. Jacobo, Cristian M. Sobarzo, Cecilia V. Pérez, María E. Matzkin, Christian Höcht, Mónica B. Frungieri et al. "Role of indoleamine 2,3-dioxygenase in testicular immune-privilege". Scientific Reports 9, n. 1 (4 novembre 2019). http://dx.doi.org/10.1038/s41598-019-52192-8.
Testo completoOxenkrug, Gregory, e Valeriya Navrotska. "Extension of life span by down-regulation of enzymes catalyzing tryptophan conversion into kynurenine: Possible implications for mechanisms of aging". Experimental Biology and Medicine, 10 giugno 2023, 153537022311794. http://dx.doi.org/10.1177/15353702231179411.
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