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Autore: Grafiati
Pubblicato: 25 luglio 2024

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1

Marquez, Raymond M., Matthew A. Singer, Norma T. Takaesu, W. Ross Waldrip, Yevgenya Kraytsberg e Stuart J. Newfeld. "Transgenic Analysis of the Smad Family of TGF-β Signal Transducers in Drosophila melanogaster Suggests New Roles and New Interactions Between Family Members". Genetics 157, n. 4 (1 aprile 2001): 1639–48. http://dx.doi.org/10.1093/genetics/157.4.1639.

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Abstract Smad signal transducers are required for transforming growth factor-β-mediated developmental events in many organisms including humans. However, the roles of individual human Smad genes (hSmads) in development are largely unknown. Our hypothesis is that an hSmad performs developmental roles analogous to those of the most similar Drosophila Smad gene (dSmad). We expressed six hSmad and four dSmad transgenes in Drosophila melanogaster using the Gal4/UAS system and compared their phenotypes. Phylogenetically related human and Drosophila Smads induced similar phenotypes supporting the hypothesis. In contrast, two nearly identical hSmads generated distinct phenotypes. When expressed in wing imaginal disks, hSmad2 induced oversize wings while hSmad3 induced cell death. This observation suggests that a very small number of amino acid differences, between Smads in the same species, confer distinct developmental roles. Our observations also suggest new roles for the dSmads, Med and Dad, in dActivin signaling and potential interactions between these family members. Overall, the study demonstrates that transgenic methods in Drosophila can provide new information about non-Drosophila members of developmentally important multigene families.
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2

Campbell, M. S., G. K. Chan e T. J. Yen. "Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase". Journal of Cell Science 114, n. 5 (1 marzo 2001): 953–63. http://dx.doi.org/10.1242/jcs.114.5.953.

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Mad1 was first identified in budding yeast as an essential component of the checkpoint system that monitors spindle assembly in mitosis and prevents premature anaphase onset. Using antibodies to the human homologue of Mad1 (HsMAD1), we have begun to characterize this protein in mammalian cells. HsMad1 is found localized at kinetochores in mitosis. The labeling is brightest in prometaphase and is absent from kinetochores at metaphase and anaphase. In cells where most chromosomes have reached the metaphase plate, those aligned at the plate show no labeling while remaining, unaligned chromosomes are still brightly labeled. We find HsMad1 associated with HsMad2. Association with p55CDC, a protein previously shown to bind HsMad2, was not detected. Surprisingly, unlike any other known mitotic checkpoint proteins, HsMad1 and HsMAD2 were found localized at nuclear pores throughout interphase. This was confirmed by co-labeling with an antibody to known nuclear pore complex proteins and by their co-purification with enriched nuclear envelope fractions. HsMad1 was identified serendipitously by its binding to a viral protein, HTLV-1 Tax, which affects transcription of viral and human proteins. The localization of HsMad1 to nuclear pore complexes suggests an alternate, non-mitotic role for the Mad1/Tax interaction in the viral transformation of cells.
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3

Iwanaga, Yoichi, Takefumi Kasai, Karen Kibler e Kuan-Teh Jeang. "Characterization of Regions in hsMAD1 Needed for Binding hsMAD2". Journal of Biological Chemistry 277, n. 34 (31 maggio 2002): 31005–13. http://dx.doi.org/10.1074/jbc.m110666200.

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4

Hogea, Bogdan Gheorghe, Mugurel Constantin Rusu, Adelina Maria Jianu, Bogdan Adrian Manta e Adrian Cosmin Ilie. "Rare Anatomic Variation: The Hepatosplenomesentericophrenic Trunk". Medicina 57, n. 2 (15 febbraio 2021): 170. http://dx.doi.org/10.3390/medicina57020170.

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The rare anatomic variants of the celiac trunk and superior mesenteric artery include the hepatosplenic, hepatosplenomesenteric (HSMT), celiacomesenteric, hepatomesenteric and gastrosplenic trunks. We report a 72-year-old female patient whose computed tomography angiograms indicated a rare anatomic feature whereby the right inferior phrenic artery was inserted in the origin of an HSMT, thus modifying it into a hepatosplenomesentericophrenic trunk (HSMPT). Above the HSMPT, the insertion of the left inferior phrenic artery in the origin of the left gastric artery determined a left gastrophrenic trunk (GPT). Proper identification of this type of rare anatomic variant is of utmost importance prior to different surgical procedures. For example, an HSMT origin of the right inferior phrenic artery is surgically relevant if this artery is an extrinsic pedicle of a hepatocellular carcinoma and is used for embolization of the tumor.
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5

Miskey, Csaba, Balázs Papp, Lajos Mátés, Ludivine Sinzelle, Heiko Keller, Zsuzsanna Izsvák e Zoltán Ivics. "The Ancient mariner Sails Again: Transposition of the Human Hsmar1 Element by a Reconstructed Transposase and Activities of the SETMAR Protein on Transposon Ends". Molecular and Cellular Biology 27, n. 12 (2 aprile 2007): 4589–600. http://dx.doi.org/10.1128/mcb.02027-06.

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Abstract (sommario):
ABSTRACT Hsmar1, one of the two subfamilies of mariner transposons in humans, is an ancient element that entered the primate genome lineage ∼50 million years ago. Although Hsmar1 elements are inactive due to mutational damage, one particular copy of the transposase gene has apparently been under selection. This transposase coding region is part of the SETMAR gene, in which a histone methylatransferase SET domain is fused to an Hsmar1 transposase domain. A phylogenetic approach was taken to reconstruct the ancestral Hsmar1 transposase gene, which we named Hsmar1-Ra. The Hsmar1-Ra transposase efficiently mobilizes Hsmar1 transposons by a cut-and-paste mechanism in human cells and zebra fish embryos. Hsmar1-Ra can also mobilize short inverted-repeat transposable elements (MITEs) related to Hsmar1 (MiHsmar1), thereby establishing a functional relationship between an Hsmar1 transposase source and these MITEs. MiHsmar1 excision is 2 orders of magnitude more efficient than that of long elements, thus providing an explanation for their high copy numbers. We show that the SETMAR protein binds and introduces single-strand nicks into Hsmar1 inverted-repeat sequences in vitro. Pathway choices for DNA break repair were found to be characteristically different in response to transposon cleavage mediated by Hsmar1-Ra and SETMAR in vivo. Whereas nonhomologous end joining plays a dominant role in repairing excision sites generated by the Hsmar1-Ra transposase, DNA repair following cleavage by SETMAR predominantly follows a homology-dependent pathway. The novel transposon system can be a useful tool for genome manipulations in vertebrates and for investigations into the transpositional dynamics and the contributions of these elements to primate genome evolution.
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6

Moosa, Aminath Shiwaza, Alvin Jia Hao Ngeow, Yuhan Yang, Zhimin Poon, Ding Xuan Ng, Eileen Koh Yi Ling e Ngiap Chuan Tan. "A Novel Smartphone App for Self-Monitoring of Neonatal Jaundice Among Postpartum Mothers: Qualitative Research Study". JMIR mHealth and uHealth 11 (22 dicembre 2023): e53291-e53291. http://dx.doi.org/10.2196/53291.

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Abstract Background Neonatal jaundice (NNJ) or hyperbilirubinemia is a ubiquitous condition in newborn infants. Currently, the transcutaneous bilirubinometer is used to screen for NNJ in health care facilities, where neonates need to be physically present (ie, a centralized model of care for NNJ screening). Mobile health (mHealth) apps present a low-cost, home-based, and noninvasive system that could facilitate self-monitoring of NNJ and could allow mothers the convenience of screening for NNJ remotely. However, end users’ acceptability of such mHealth apps is of fundamental importance before the incorporation of such apps into clinical practice. Objective The study aimed to explore the perception of postpartum mothers toward self-monitoring of NNJ using a novel mHealth app. Methods Mothers attending video consultations for early postpartum care at 2 Singapore primary care clinics watched an instructional video for a hyperbilirubinemia-screening mHealth app (HSMA). An independent researcher used a semistructured topic guide to conduct in-depth interviews with 25 mothers, assessing their views on HSMAs. All interviews were audio recorded, transcribed verbatim, and checked for accuracy before data analysis. Two researchers independently analyzed the transcripts via thematic analysis. Data were managed using NVivo qualitative data management software. Results The identified themes were grouped under perceived usability and utility. Mothers valued the convenience and utility of HSMAs for remote monitoring of NNJ. They appreciated the objectivity the app readings provided compared to visual inspection. However, they perceived that the app’s applicability would be restricted to severe jaundice, were concerned about its accuracy and restriction to the English language, and lacked confidence in using it. Nevertheless, they were willing to use it once its accuracy was proven and when they received adequate guidance from health care professionals. They also suggested including an action plan for the measured readings and clinical signs within the app. Mothers proposed pairing teleconsultations with HSMAs to boost their confidence and enhance adoption. Conclusions Mothers were receptive to using HSMAs but had concerns. Multiple languages, proof of accuracy, and resources to guide users should be incorporated into the app in the next phase to increase its successful adoption. Complementing such apps with a teleconsultation service presents a plausible and pragmatic NNJ care delivery model in general practice.
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7

Gemma, Akihiko, Koichi Hagiwara, Francoise Vincent, Yang Ke, Amy R. Hancock, Makoto Nagashima, William P. Bennett e Curtis C. Harris. "hSmad5 gene, a human hSmad family member: its full length cDNA, genomic structure, promoter region and mutation analysis in human tumors". Oncogene 16, n. 7 (febbraio 1998): 951–56. http://dx.doi.org/10.1038/sj.onc.1201614.

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8

Nabokina, Svetlana M., Veedamali S. Subramanian e Hamid M. Said. "Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter". American Journal of Physiology-Gastrointestinal and Liver Physiology 300, n. 4 (aprile 2011): G561—G567. http://dx.doi.org/10.1152/ajpgi.00530.2010.

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Abstract (sommario):
Intestinal absorption of biotin is mediated via the sodium-dependent multivitamin transporter (SMVT). Studies from our laboratory and others have characterized different aspects of the human SMVT (hSMVT), but nothing is currently known about protein(s) that may interact with hSMVT and affect its physiology/biology. In this study, a PDZ-containing protein PDZD11 was identified as an interacting partner with hSMVT using yeast two-hybrid screen of a human intestinal cDNA library. The interaction between hSMVT and PDZD11 was confirmed by in vitro GST-pull-down assay and in vivo in a mammalian cell environment by a two-hybrid luciferase and coimmunoprecipitation assays. Furthermore, confocal imaging of live human intestinal epithelial HuTu-80 cells expressing hSMVT-GFP and DsRed-PDZD11 demonstrated colocalization of these two proteins. We also examined the functional consequence of the interaction between hSMVT and PDZD11 in HuTu-80 cells and observed significant induction in [3H]biotin uptake upon coexpression of hSMVT and PDZD11. In contrast, knocking down of PDZD11 with gene-specific small interfering RNA led to a significant decrease in biotin uptake; biotinylation assay showed this to be associated with a marked decrease in level of expression of hSMVT at the cell membrane. By truncation approach, we also demonstrated that the PDZ binding domain that is located in the COOH-terminal tail of hSMVT polypeptide is involved in the interaction with PDZD11. These results demonstrate for the first time that PDZD11 is an interacting partner with hSMVT in intestinal epithelial cells and that this interaction affects hSMVT function and cell biology.
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9

Reidling, Jack C., e Hamid M. Said. "Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo". American Journal of Physiology-Cell Physiology 292, n. 4 (aprile 2007): C1305—C1312. http://dx.doi.org/10.1152/ajpcell.00360.2006.

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Abstract (sommario):
The mechanism of biotin uptake in human intestine has been well characterized and involves the human sodium-dependent multivitamin transporter (hSMVT), yet little is known about the molecular/transcriptional regulation of the system. Previous investigations cloned the 5′ regulatory region of the hSMVT gene and identified the minimal promoter. To expand these investigations, we compared activity of the hSMVT promoter in three human intestinal epithelial cell lines (NCM460, Caco-2, and HuTu-80) and contrasted a renal epithelial cell line (HEK-293). We analyzed the role of putative cis-elements in regulating promoter activity and confirmed activity of the cloned hSMVT promoter in vivo. In vitro studies demonstrated that all cell lines utilized the same minimal promoter region, and mutation of specific cis-regulatory elements [Kruppel-like factor 4 (KLF-4) and activator protein-2 (AP-2)] led to a decrease in promoter activity in all intestinal cell types but not in renal cells. Using electrophoretic mobility shift assays, we identified two specific DNA/protein complexes. Using oligonucleotide competition and antibody supershift analysis, we determined that KLF-4 and AP-2 were involved in forming the complexes. In HEK-293 cells, overexpressing KLF-4 increased the endogenous hSMVT message levels threefold and activated a cotransfected hSMVT promoter-reporter construct. In vivo studies using hSMVT promoter-luciferase transgenic mice established physiological relevance and showed the pattern of hSMVT promoter expression to be similar to endogenous mouse SMVT mRNA expression. The results demonstrate, for the first time, the importance of KLF-4 and AP-2 in regulating the activity of the hSMVT promoter in the intestine and provide direct in vivo confirmation of hSMVT promoter activity.
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10

Subramanian, Veedamali S., Jonathan S. Marchant, Michael J. Boulware, Thomas Y. Ma e Hamid M. Said. "Membrane targeting and intracellular trafficking of the human sodium-dependent multivitamin transporter in polarized epithelial cells". American Journal of Physiology-Cell Physiology 296, n. 4 (aprile 2009): C663—C671. http://dx.doi.org/10.1152/ajpcell.00396.2008.

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Abstract (sommario):
The human sodium-dependent multivitamin transporter (hSMVT) mediates sodium-dependent uptake of biotin in renal and intestinal epithelia. To date, however, there is nothing known about the structure-function relationship or targeting sequences in the hSMVT polypeptide that control its polarized expression within epithelia. Here, we focused on the role of the COOH-terminal tail of hSMVT in the targeting and functionality of this transporter. A full-length hSMVT-green fluorescent protein (GFP) fusion protein was functional and expressed at the apical membrane in renal and intestinal cell lines. Microtubule disrupting agents disrupted the mobility of trafficking vesicles and impaired cell surface delivery of hSMVT, which was also prevented in cells treated with dynamitin (p50), brefeldin, or monensin. Progressive truncation of the COOH-terminal tail impaired the functionality and targeting of the transporter. First, biotin transport decreased by approximately 20–30% on deletion of up to 15 COOH-terminal amino acids of hSMVT, a decrease mimicked solely by deletion of the terminal PDZ motif (TSL). Second, deletions into the COOH-terminal tail (between residues 584-612, containing a region of predicted high surface accessibility) resulted in a further drop in hSMVT transport (to ∼40% of wild-type). Third, apical targeting was lost on deletion of a helical-prone region between amino acids 570-584. We conclude that the COOH tail of hSMVT contains several determinants important for polarized targeting and biotin transport.
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11

C., F. L. "HSMAI University". Cornell Hotel and Restaurant Administration Quarterly 37, n. 4 (agosto 1996): 16. http://dx.doi.org/10.1177/001088049603700413.

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12

Reidling, Jack C., Svetlana M. Nabokina e Hamid M. Said. "Molecular mechanisms involved in the adaptive regulation of human intestinal biotin uptake: a study of the hSMVT system". American Journal of Physiology-Gastrointestinal and Liver Physiology 292, n. 1 (gennaio 2007): G275—G281. http://dx.doi.org/10.1152/ajpgi.00327.2006.

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Abstract (sommario):
Biotin, a water-soluble micronutrient, is vital for cellular functions, including growth and development. The human intestine utilizes the human sodium-dependent multivitamin transporter (hSMVT) for biotin uptake. Evidence exists showing that the intestinal biotin uptake process is adaptively regulated during biotin deficiency. Nothing, however, is known about molecular mechanism(s) involved during this adaptive regulation. This study compared two human-derived intestinal epithelial cell lines (HuTu-80 and Caco-2) during biotin-deficient or biotin-sufficient states and with an approach that assessed carrier-mediated biotin uptake, hSMVT protein and RNA levels, RNA stability, and hSMVT promoter activity. The results showed that during biotin deficiency, a significant and specific upregulation in carrier-mediated biotin uptake occurred in both human intestinal epithelial cell lines and that this increase was associated with an induction in protein and mRNA levels of hSMVT. The increase in mRNA levels was not due to an increase in RNA stability but was associated with an increase in activity of the hSMVT promoter in transfected human intestinal cells. Using promoter deletion constructs and mutational analysis in transiently transfected HuTu-80 and Caco-2 cells, a biotin deficiency-responsive region was mapped to a 103-bp area within the hSMVT promoter that contains gut-enriched Kruppel-like factor (GKLF) sites that confer the response to biotin deficiency. These results confirm that human intestinal biotin uptake is adaptively regulated and provide novel evidence demonstrating that the upregulation is not mediated via changes in hSMVT RNA stability but rather is due to transcriptional regulatory mechanism(s) that likely involve GKLF sites in the hSMVT promoter.
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13

Balamurugan, Krishnaswamy, Nosratola D. Vaziri e Hamid M. Said. "Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects". American Journal of Physiology-Renal Physiology 288, n. 4 (aprile 2005): F823—F831. http://dx.doi.org/10.1152/ajprenal.00375.2004.

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Abstract (sommario):
Cellular and molecular regulation of renal biotin uptake in humans is not well defined. The contribution of the human Na+-dependent multivitamin transporter (hSMVT) to carrier-mediated biotin uptake by human proximal tubular epithelial cells is not clear. The aim of this study was to address these issues, with the human-derived proximal tubular epithelial HK-2 cells used as a model. First, we characterized the mechanism of biotin uptake by these cells and obtained evidence for involvement of an Na+-, temperature-, and energy-dependent carrier-mediated uptake system. This system was inhibited by the biotin structural analog desthiobiotin, pantothenic acid, and lipoate. These findings suggest involvement of the hSMVT system in the uptake process. This was confirmed by demonstrating that the hSMVT system is expressed in HK-2 cells at the protein and mRNA levels and by selective silencing of the hSMVT gene with the use of gene-specific small interfering RNAs, which led to specific and significant inhibition of carrier-mediated biotin uptake. Of the two recently cloned promoters of the hSMVT gene, promoter 1 was more active than promoter 2 in these cells. Pretreatment of HK-2 cells with modulators of PKC- and Ca2+/calmodulin-mediated pathways (but not those that modulate PKA-, protein tyrosine kinase-, or nitric oxide-mediated pathways) led to significant alterations in biotin uptake. Maintaining the HK-2 cells in a biotin-deficient growth medium led to a marked upregulation in biotin transport, which was associated with an increase in hSMVT protein and RNA levels and an increase in activity of the hSMVT promoters. These results demonstrate that biotin uptake by human renal epithelial cells occurs via the hSMVT system and that the process is regulated by intracellular PKC- and Ca2+/calmodulin-mediated pathways. The uptake process appears to be adaptively regulated by extracellular biotin level, which involves transcriptional regulatory mechanism(s).
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14

Ghosal, Abhisek, e Hamid M. Said. "Structure-function activity of the human sodium-dependent multivitamin transporter: role of His115 and His254". American Journal of Physiology-Cell Physiology 300, n. 1 (gennaio 2011): C97—C104. http://dx.doi.org/10.1152/ajpcell.00398.2010.

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Abstract (sommario):
Intestinal absorption of biotin occurs via a Na+-dependent carrier-mediated process that involves the sodium-dependent multivitamin transporter (SMVT; product of the Slc5a6 gene). The SMVT system is exclusively expressed at the apical membrane domain of the polarized intestinal epithelial cells. Whereas previous studies from our laboratory and others have characterized different physiological and biological aspects of SMVT, little is currently known about its structure-function activity relationship. Using site-directed mutagenesis approach, we examined the role of the positively charged histidine (His) residues of the human SMVT (hSMVT) in transporting the negatively charged biotin. Of the seven conserved (across species) His residues in the hSMVT polypeptide, only His115 and His254 were found to be important for the function of hSMVT as their mutation led to a significant reduction in carrier-mediated biotin uptake. This inhibition was mediated via a significant reduction in the maximal velocity ( Vmax), but not the apparent Michaelis constant ( Km), of the biotin uptake process and was not related to the charge of the His residue. The inhibition was also not due to changes in transcriptional or translational efficiency of the mutated hSMVT compared with wild-type carrier. However, surface biotinylation assay showed a significant reduction in the level of expression of the mutated hSMVT at the cell surface, a finding that was further confirmed by confocal imaging. Our results show important role for His115 and His254 residues in hSMVT function, which is most probably mediated via an effect on level of hSMVT expression at the cell membrane.
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15

Qian, Hui, Hong Nan Li, Di Cui e Huai Chen. "Case Studies of Seismic Vibration Control of Civil Structures Using Shape Memory Alloys". Advanced Materials Research 243-249 (maggio 2011): 5427–34. http://dx.doi.org/10.4028/www.scientific.net/amr.243-249.5427.

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Shape memory alloys (SMAs) are unique class materials that have the ability to undergo large deformations, while returning to their undeformed shape through either the applications of heat (SME) or removal of stress (SE). The unique properties lead to their wide applications in the biomedical, mechanical, aerospace, commercial industries, and recently in civil engineering. The paper presents two case studies of structural seismic vibration control using SMAs. The first one is a study of the SMA reinforced RC members. Two innovative applications in RC members, such as SMA-based Precast Concrete Frame Connection (SMA-PCFC), and SMA reinforced RC short column, were proposed. Moreover, the self-rehabilitation properties of SMAs-based Intelligent Reinforced Concrete Beams (SMA-IRCBs) were further experimentally investigated. The results show that SMAs can improve the mechanical properties of concrete members. SMA reinforced RC members have unique seismic performance compared to ordinarily steel reinforced concrete members. The second one is a study of the structural energy dissipation system using SMAs damping device. An innovative hybrid SMAs friction device (HSMAFD) which consists of pre-tensioned superelastic SMA wires and friction devices (FD) was presented. The results of cyclic tensile tests show that the HSMAFD exhibits stable large energy dissipation capacity and re-centering feature. The effectiveness of the HSMAFD in reducing horizontal response of structures subjected to strong seismic excitations was verified through shaking table tests carried out on a reduced-scale symmetric steel frame model with and without the HSMAFD.
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Safitri, Ratu, Rika Okta Pylia e Shabarni Gaffar. "Amylolytic Geobacillus from Kamojang Crater Hot Springs, Garut, Indonesia". Research Journal of Chemistry and Environment 26, n. 10 (25 settembre 2022): 62–69. http://dx.doi.org/10.25303/2610rjce062069.

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The hot springs area of Kamojang Crater, Garut Indonesia is a prospective habitat for amylase-producing thermophile bacteria. Researchers have been drawn to thermophilic bacteria because they produce thermostable enzymes that can be used in biotechnological processes. Thermostable enzyme produced by thermophilic bacteria is used extensively in industrial processes. This study aims to isolate and characterize the amylolytic thermophilic bacteria and archaea from Kamojang Crater hot springs, Garut, Indonesia. Samples were grown in Thermus, Luria Bertani and hot spring medium at 70°C and pH 6, characterized morphologically, microscopically, biochemically etc. Two amylolytic thermophilic bacteria HSM6T1 and TM6T2SP1 were successfully identified, which have amylolytic index 1,07 dan 0,31 mm respectively. Molecular identification using 16S rDNA sequencing showed that the HSM6T1 has 99.93% similarity with Geobacillus sp. strain PCH167 and the TM6T2SP1 has 99.86% similarities with Geobacillus thermoleovorans strain CCB-US3-UF5.
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Liu, Danxu, Julien Bischerour, Azeem Siddique, Nicolas Buisine, Yves Bigot e Ronald Chalmers. "The Human SETMAR Protein Preserves Most of the Activities of the Ancestral Hsmar1 Transposase". Molecular and Cellular Biology 27, n. 3 (27 novembre 2006): 1125–32. http://dx.doi.org/10.1128/mcb.01899-06.

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Abstract (sommario):
ABSTRACT Transposons have contributed protein coding sequences to a unexpectedly large number of human genes. Except for the V(D)J recombinase and telomerase, all remain of unknown function. Here we investigate the activity of the human SETMAR protein, a highly expressed fusion between a histone H3 methylase and a mariner family transposase. Although SETMAR has demonstrated methylase activity and a DNA repair phenotype, its mode of action and the role of the transposase domain remain obscure. As a starting point to address this problem, we have dissected the activity of the transposase domain in the context of the full-length protein and the isolated transposase domain. Complete transposition of an engineered Hsmar1 transposon by the transposase domain was detected, although the extent of the reaction was limited by a severe defect for cleavage at the 3′ ends of the element. Despite this problem, SETMAR retains robust activity for the other stages of the Hsmar1 transposition reaction, namely, site-specific DNA binding to the transposon ends, assembly of a paired-ends complex, cleavage of the 5′ end of the element in Mn2+, and integration at a TA dinucleotide target site. SETMAR is unlikely to catalyze transposition in the human genome, although the nicking activity may have a role in the DNA repair phenotype. The key activity for the mariner domain is therefore the robust DNA-binding and looping activity which has a high potential for targeting the histone methylase domain to the many thousands of specific binding sites in the human genome provided by copies of the Hsmar1 transposon.
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18

van Ryzin, Garrett J. "HSMAI Revenue Management Strategy Conference". Journal of Revenue and Pricing Management 7, n. 1 (28 febbraio 2008): 119–20. http://dx.doi.org/10.1057/palgrave.rpm.5160123.

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19

Kohno, Haruhiko. "Convergence improvement of the simultaneous relaxation method used in the finite element analysis of incompressible fluid flows". Engineering Computations 37, n. 2 (31 luglio 2019): 481–500. http://dx.doi.org/10.1108/ec-02-2019-0069.

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Abstract (sommario):
Purpose This paper aims to present an improved finite element method used for achieving faster convergence in simulations of incompressible fluid flows. For stable computations of incompressible fluid flows, it is important to ensure that the flow field satisfies the equation of continuity in each element of a generally distorted mesh. The study aims to develop a numerical approach that satisfies this requirement based on the highly simplified marker-and-cell (HSMAC) method and increases computational speed by introducing a new algorithm into the simultaneous relaxation of velocity and pressure. Design/methodology/approach First, the paper shows that the classical HSMAC method is equivalent to a Jacobi-type method in terms of the simultaneous relaxation of velocity and pressure. Then, a Gauss–Seidel or successive over-relaxation (SOR)-type method is introduced in the Newton–Raphson iterations to take into account all the derivative terms in the first-order Taylor series expansion of a nodal-averaged error explicitly. Here, the nine-node quadrilateral (Q2–Q1) elements are used. Findings The new finite element approach based on the improved HSMAC algorithm is tested on fluid flow problems including the lid-driven square cavity flow and the flow past a circular cylinder. The results show significant improvement of the convergence property with the accuracy of the numerical solutions kept unchanged even on a highly distorted mesh. Originality/value To the best of the author’s knowledge, the idea of using the Gauss–Seidel or SOR method in the simultaneous relaxation procedure of the HSMAC method has not been proposed elsewhere.
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Yang, Ying, e Xiang Rong Wang. "Application of Hydrolytic Styrene-Maleic Anhydride Copolymer in Denim Cellulase Washing". Advanced Materials Research 396-398 (novembre 2011): 1071–74. http://dx.doi.org/10.4028/www.scientific.net/amr.396-398.1071.

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Abstract (sommario):
In order to provide the theoretical basis for the development of anti-backstaining agent. The copolymer of styrene-maleic anhydride(SMA) was synthesized by free radical solution polymerization using benzoyl peroxide(BPO) as initiator, toluene as solvent, the hydrolytic styrene-maleic anhydride copolymer (HSMA) was obtained by hydrolysis with Sodium hydroxide solution, the structure of HSMA was characterized by FI-IR. The HSMA was employed as anti-backstaining agent in the process of denim cellulase washing. The results showed that HSMA had little effect on the enzyme activity, the HSMA had excellent anti-backstaining capability, the effect of anti-backstaining increased with content of maleic anhydride in the copolymer increasing.
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21

Li, Y., e R. Benezra. "Identification of a Human Mitotic Checkpoint Gene: hsMAD2". Science 274, n. 5285 (11 ottobre 1996): 246–48. http://dx.doi.org/10.1126/science.274.5285.246.

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22

Gil, Estel, Assumpcio Bosch, David Lampe, Jose M. Lizcano, Jose C. Perales, Olivier Danos e Miguel Chillon. "Functional Characterization of the Human Mariner Transposon Hsmar2". PLoS ONE 8, n. 9 (11 settembre 2013): e73227. http://dx.doi.org/10.1371/journal.pone.0073227.

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23

Solomin, Vladimir A., Andrei V. Solomin, Nadezda A. Trubitsina, Larisa L. Zamchina e Anastasia A. Chekhova. "New technology for manufacturing inductors of linear induction motors for magnetic-levitation transport". Transportation Systems and Technology 4, n. 3 suppl. 1 (19 novembre 2018): 351–64. http://dx.doi.org/10.17816/transsyst201843s1351-364.

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Abstract. Background: Significant economic growth in many countries of the world can contribute to an increase in the speed of movement of modern and fundamentally new vehicles. This will increase the turnover of goods during the transportation of goods, revive international trade, increase the comfort of passengers and reduce their travel time. Aim: The solution of this problem is the development and wide application of high-speed magnetic-levitation transport (HSMLT) with linear traction engines. It is promising to use linear induction motors (LIM) for the HSMLT drive, which can have various design versions. Linear induction motors come with a longitudinal, transverse and longitudinal-transverse closure of the magnetic flux. LIM inductors can be installed on both high-speed transport crews and in the HSMLT track structure, as it was done in the People’s Republic of China, where express trains on magnetic suspension connect Shanghai with the airport and reliably operate for more than 10 years. The main elements of the inductor of a linear induction motor are a magnetic core (ferromagnetic core) a multiphase (usually three-phase) winding. With the development of high-speed magnetic-levitation transport, the issues of improving the manufacturing technology of various HSMLT devices, including the methods for producing inductors of linear induction motors, will become increasingly relevant. Traditionally, LIM inductors are assembled from pre-manufactured individual parts. Methods: An integral technology for manufacturing inductors of linear induction motors for high-speed magnetic-levitation transport is proposed and considered by the method of spraying materials onto a substrate through replaceable stencils. The new technology eliminates the alternate manufacture of individual assemblies and parts and their subsequent assembly to obtain a finished product. A method for determining the size of stencils for manufacturing one of the inductor variants of a linear induction motor is proposed as an example. Conclusion: Integral manufacturing technology is promising for the creation of high-speed magnetic-levitation transport.
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Makower, Åsa, Erik Arnelöf, Tommy Andersson, Per-Olof Edlund, Susanne Gustavsson, Juliette Janson, Stefan Svensson Gelius e Agneta Tjernberg. "Robust LC–MS/MS methods for analysis of heparan sulfate levels in CSF and brain for application in studies of MPS IIIA". Bioanalysis 11, n. 15 (agosto 2019): 1389–403. http://dx.doi.org/10.4155/bio-2019-0095.

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Aim: Accumulation of heparan sulfate (HS) is associated with the neurodegenerative disorder Mucopolysaccharidosis type IIIA (MPS IIIA). Here, we compare HS levels in brain and cerebrospinal fluid (CSF) of MPS IIIA mice after treatment with a chemically modified sulfamidase (CM-rhSulfamidase). Materials & methods: Two LC–MS/MS methods were adapted from literature methodology, one to measure HS metabolites (HSmet), the other to measure digests of HS after heparinase treatment (HSdig). Results: The HSmet and HSdig methods showed similar relative reduction of HS in brain after CM-rhSulfamidase administration to MPS IIIA mice and the reduction was reflected also in CSF. Conclusion: The results of the two methods correlated and therefore the HSdig method can be used in clinical studies to determine HS levels in CSF from patients with MPS IIIA.
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25

Xiang, Yue, Bo Yu, Qing Yuan e Dongliang Sun. "GPU Acceleration of CFD Algorithm: HSMAC and SIMPLE". Procedia Computer Science 108 (2017): 1982–89. http://dx.doi.org/10.1016/j.procs.2017.05.124.

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26

Gürses, Dildar, Sujin Bureerat, Sadiq M. Sait e Ali Rıza Yıldız. "Comparison of the arithmetic optimization algorithm, the slime mold optimization algorithm, the marine predators algorithm, the salp swarm algorithm for real-world engineering applications". Materials Testing 63, n. 5 (1 maggio 2021): 448–52. http://dx.doi.org/10.1515/mt-2020-0076.

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Abstract (sommario):
Abstract This paper focuses on a comparision of recent algorithms such as the arithmetic optimization algorithm, the slime mold optimization algorithm, the marine predators algorithm, and the salp swarm algorithm. The slime mold algorithm (SMA) is a recent optimization algorithm. In order to strengthen its exploitation and exploration abilities, in this paper, a new hybrid slime mold algorithm-simulated annealing algorithm (HSMA-SA) has been applied to structural engineering design problems. As a result of the rules and practices that have become mandatory for fuel emissions by international organizations and governments, there is increasing interest in the design of vehicles with minimized fuel emissions. Many scientific studies have been conducted on the use of metaheuristic methods for the optimum design of vehicle components, especially for reducing vehicle weight. With the inspiration obtained from the above-mentioned methods, the HSMA-SA has been studied to solve the shape optimization of a design case to prove how the HSMA-SA can be used to solve shape optimization problems. The HSMA-SA provides better results as an arithmetic optimization algorithm than the slime mold optimization algorithm, the marine predators algorithm, and the salp swarm algorithm.
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27

Chen, Qiujia, Suk-Hee Lee e Millie Georgiadis. "Preliminary crystallographic analysis of SETMAR bound to DNA". Acta Crystallographica Section A Foundations and Advances 70, a1 (5 agosto 2014): C206. http://dx.doi.org/10.1107/s2053273314097939.

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Abstract (sommario):
SETMAR, a recently identified double strand break (DSB) repair enzyme in the human genome, contains an N-terminal SET domain and a C-terminal MAR domain. This chimeric protein arose through the fusion of a mariner-family DNA transposase gene, Hsmar1, downstream of a SET histone methyltransferase gene approximately 50 million years ago [1]. Although the SETMAR transposase domain retains the ability to bind terminal inverted repeat (TIR) DNA sequence, which is the hallmark of DNA transposons, it is no longer a functional transposase [2]. Nonetheless, the transposase domain with only 19 amino acid substitutions as compared to the ancestral Hsmar1 transposase has been under a strong selective evolutionary pressure suggesting that the transposase domain is functionally important. Determining how SETMAR interacts with DNA is central to understanding the molecular basis of its evolved DNA repair activity. Toward this goal, we have focused initially on the interaction of the DNA-binding domain (DBD) of the SETMAR transposase domain with TIR DNA. The DBD of SETMAR has been overexpressed and purified. A complex formed between SETMAR DBD and its transposon TIR DNA has been crystallized by using the hanging-drop vapor diffusion method. The crystals diffract to 3.15 Å resolution and exhibit orthorhombic symmetry (C2221), with unit-cell dimensions of a=72.233 Å, b=164.385 Å, and c=67.957 Å. As there is no suitable search model available, we are currently pursuing experimental phasing approaches in order to solve this structure. We anticipate the structural analysis of DBD of SETMAR bound to transposon DNA will provide insight into the mechanism by which SETMAR recognizes both TIR and non-TIR DNA.
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28

Taran, Ihor, Anatolii Bondarenko, Oleksii Novytskyi, Zhemazhan Zhanbirov e Iryna Klymenko. "Modeling of a braking process of a mine diesel locomotive in terms of different rail track conditions". E3S Web of Conferences 201 (2020): 01018. http://dx.doi.org/10.1051/e3sconf/202020101018.

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The paper considers braking process of mine diesel locomotive with hydrostatic mechanical transmission (HSMT) operating according to “input differential” scheme. Braking process is modeled in terms of kinematic motor disconnection from wheels under maximum possible braking moments on wheels.Showing up and systematizing of basic regularities concerning the distribution of power flows within closed transmission contour in the process of braking have been implemented with the help of software support developed by means of MatLab/Simulink. The simulation results of braking due to the hydrostatic transmission and the braking system during the movement of a diesel locomotive in the transport and tractive ranges are presented in the form of graphical dependences. It has been determined that when a kinematic disconnection of a mechanical branch takes place within the closed loop of HSMT No. 1 by means of a clutch, neither ascent/descent angle nor net tractive effort of mine diesel locomotive effect significantly the distribution of kinematic, power, and energy parameters of the HSMT.
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29

NAKAKAYA, Akihiko, Tomoyuki EDA e Tomohiro MATUMURA. "LES OF OPEN-CHANNEL FLOW USING MODIFIED HSMAC METHOD". PROCEEDINGS OF HYDRAULIC ENGINEERING 49 (2005): 661–66. http://dx.doi.org/10.2208/prohe.49.661.

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30

Robertson, Hugh M., e Karen L. Zumpano. "Molecular evolution of an ancient mariner transposon, Hsmarl, in the human genome". Gene 205, n. 1-2 (dicembre 1997): 203–17. http://dx.doi.org/10.1016/s0378-1119(97)00472-1.

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31

Sasseville, Louis J., e Jean-Yves Lapointe. "The Transport Mechanism of the Human Sodium Myo-Inositol Cotransporter 2 (hSMIT2)". Biophysical Journal 96, n. 3 (febbraio 2009): 685a. http://dx.doi.org/10.1016/j.bpj.2008.12.3618.

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32

Wang, Mingtai, e Lide Zhang. "Precipitation of multilayered core–shell TiO2 composite nanoparticles onto polymer layers". Journal of Materials Research 16, n. 3 (marzo 2001): 765–73. http://dx.doi.org/10.1557/jmr.2001.0105.

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Abstract (sommario):
A composite film of titanium dioxide (TiO2) nanoparticles and hydrolyzed styrene–maleic anhydride alternating copolymer (HSMA) was obtained on a substrate when a TiCl4 solution was heated at 80 °C with a spin-cast thin HSMA film present in the solution. The composite film was characterized with x-ray photoelectron spectroscopy and transmission electron microscopy. Results revealed that TiO2 nanoparticles discretely dispersed on the polymer layer, and they were dominantly rutile phase, of a spherical shape and 18–20 nm in diameter. In contrast, mainly amorphous TiO2 powders were obtained from the identical TiCl4 solution by drying the solution with the absence of the HSMA film. The TiO2 nanoparticles deposited on the polymer layer were regarded to contain polymer chains, and a multilayered core–shell model was suggested for the formation of these composite nanoparticles. It is regarded that the core of a composite particle consisted of an anatase-phase TiO2 colloidal nanoparticle, while the shell layer was made of rutile-phase TiO2/polymer multilayers; the composite particles formed by a layer-by-layer self-assembly of TiO2 and polymer layers analogous to biomineralization, where the polymer promoted the crystallization of rutile-phase TiO2 when TiO2 deposited from solution.
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33

FUJISHIRO, Kenta, Hisashi SINDO e Nobuatsu TANAKA. "104 Parallel processing using GPGPU of HSMAC-based CFD code". Proceedings of Ibaraki District Conference 2011.19 (2011): 7–8. http://dx.doi.org/10.1299/jsmeibaraki.2011.19.7.

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34

Piao, Ming Jun, Chung Hee Park, Hoon Huh e Ik Jin Lee. "Validation of Dynamic Hardening Models with Taylor Impact Tests at High Strain Rates". Key Engineering Materials 626 (agosto 2014): 389–96. http://dx.doi.org/10.4028/www.scientific.net/kem.626.389.

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This paper is concerned with the hardening behavior of 4340 steel at high strain rates from 104s-1to 106s-1. Tension tests were conducted using Instron 5583, HSMTM and SHPB testing machines at a wide range of strain rate from 10-3s-1to 103s-1. Three different impact velocities were performed for the Taylor impact tests to evaluate the reliability of Johnson–Cook model, modified Johnson–Cook model, modified Khan–Huang model, and Lim–Huh model at high strain rates for 4340 steel.
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35

Wang, Zaochang, Junjie Hu, Wang He, Humin Gong, Weihua Xu, Zhichao Ma e Xinping Chen. "High Expression of hsMAD2 in the Villi of Spontaneously Aborted Embryo with Chromosomal Abnormality". Open Journal of Obstetrics and Gynecology 11, n. 06 (2021): 763–72. http://dx.doi.org/10.4236/ojog.2021.116071.

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36

Claeys Bouuaert, Corentin, e Ronald Chalmers. "Hsmar1 Transposition Is Sensitive to the Topology of the Transposon Donor and the Target". PLoS ONE 8, n. 1 (14 gennaio 2013): e53690. http://dx.doi.org/10.1371/journal.pone.0053690.

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37

Tanaka, Kouji, Junji Nishioka, Keiko Kato, Akiko Nakamura, Tomomi Mouri, Chikao Miki, Masato Kusunoki e Tsutomu Nobori. "Mitotic Checkpoint Protein hsMAD2 as a Marker Predicting Liver Metastasis of Human Gastric Cancers". Japanese Journal of Cancer Research 92, n. 9 (settembre 2001): 952–58. http://dx.doi.org/10.1111/j.1349-7006.2001.tb01186.x.

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38

OKUYAMA, Yohei, e Satoru USHIJIMA. "C-HSMAC METHOD FOR INCOMPRESSIBLE FLOWS WITH UNSTRUCTURED COLLOCATED GRID SYSTEM". PROCEEDINGS OF HYDRAULIC ENGINEERING 48 (2004): 703–8. http://dx.doi.org/10.2208/prohe.48.703.

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39

LeMone, Margaret A., Mukul Tewari, Fei Chen e Jimy Dudhia. "Objectively Determined Fair-Weather NBL Features in ARW-WRF and Their Comparison to CASES-97 Observations". Monthly Weather Review 142, n. 8 (1 agosto 2014): 2709–32. http://dx.doi.org/10.1175/mwr-d-13-00358.1.

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Abstract (sommario):
Abstract Heights of nocturnal boundary layer (NBL) features are determined using vertical profiles from the Advanced Research Weather Research and Forecasting Model (ARW-WRF), and then compared to data for three moderately windy fair-weather nights during the April–May 1997 Kansas-based Cooperative Atmosphere–Surface Exchange Study (CASES-97) to evaluate the success of four PBL schemes in replicating observations. The schemes are Bougeault–LaCarrere (BouLac), Mellor–Yamada–Janjić (MYJ), quasi-normal scale elimination (QNSE), and Yonsei University (YSU) versions 3.2 and 3.4.1. This study’s chosen objectively determined model NBL height h estimate uses a turbulence kinetic energy (TKE) threshold equal to 5% , where TKE′ is relative to its background (free atmosphere) value. The YSU- and MYJ-determined h could not be improved upon. Observed heights of the virtual temperature maximum hTvmax and wind speed maximum hSmax, and the heights h1wsonde and h2wsonde, between which the radiosonde slows from ~5 to ~3 m s−1 as it rises from turbulent to nonturbulent air, and thus brackets h, were used for comparison to model results. The observations revealed a general pattern: hTvmax increased through the night, and hTvmax and hSmax converged with time, and the two mostly lay between h1wsonde and h2wsonde after several hours. Clear failure to adhere to this pattern and large excursions from observations or other PBL schemes revealed excess mixing for BouLac and YSU version 3.2 (but not version 3.4.1) and excess thermal mixing for QNSE under windy conditions. Observed friction velocity was much smaller than model values, with differences consistent with the observations reflecting local skin drag and the model reflecting regional form drag + skin drag.
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40

Sugio, Kazuaki, Daisei Inoda, Masayuki Masuda, Isao Azumaya, Shotaro Sasaki, Kazumi Shimono, Vadivel Ganapathy e Seiji Miyauchi. "Transport of 2,4-dichloro phenoxyacetic acid by human Na+-coupled monocarboxylate transporter 1 (hSMCT1, SLC5A8)". Drug Metabolism and Pharmacokinetics 34, n. 1 (febbraio 2019): 95–103. http://dx.doi.org/10.1016/j.dmpk.2018.10.004.

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41

Jeong, Sook-Jung, Hyun-Jin Shin, So-Jung Kim, Geun-Hyoung Ha, Bok-Im Cho, Kwan-Hyuck Baek, Chang-Min Kim e Chang-Woo Lee. "Transcriptional Abnormality of the hsMAD2 Mitotic Checkpoint Gene Is a Potential Link to Hepatocellular Carcinogenesis". Cancer Research 64, n. 23 (1 dicembre 2004): 8666–73. http://dx.doi.org/10.1158/0008-5472.can-03-3455.

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42

Otake, Kohei, Keiichi Uchida, Kouji Tanaka, Yuhki Koike, Mikihiro Inoue, Kohei Matsushita, Motoko Ueeda et al. "HsMAD2 mRNA expression may be a predictor of sensitivity to paclitaxel and survival in neuroblastoma". Pediatric Surgery International 27, n. 2 (3 novembre 2010): 217–23. http://dx.doi.org/10.1007/s00383-010-2780-5.

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43

Zehnpfennig, Britta, Pattama Wiriyasermkul, David A. Carlson e Matthias Quick. "Interaction of α-Lipoic Acid with the Human Na+/Multivitamin Transporter (hSMVT)". Journal of Biological Chemistry 290, n. 26 (13 maggio 2015): 16372–82. http://dx.doi.org/10.1074/jbc.m114.622555.

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44

Moody, Daryn. "The 1999 HSMAI Sales and Marketing Summit: Gateway to a Changing World". Journal of Vacation Marketing 5, n. 4 (ottobre 1999): 400–403. http://dx.doi.org/10.1177/135676679900500409.

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45

Yamaguchi, H., I. Kobori e N. Kobayashi. "Characteristics of a magnetic fluid heat transport device Part 1: Numerical simulation of flow and heat transport phenomena". Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 214, n. 4 (1 aprile 2000): 549–61. http://dx.doi.org/10.1243/0954406001523902.

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Abstract (sommario):
A numerical analysis is conducted in order to study the flow state and thermal characteristics of a magnetic fluid heat transport device. A simple geometrical model of the device is considered in the present numerical study. The highly simplified marker-and-cell (HSMAC) method is adopted for the numerical analysis, where the transient solutions are obtained in the two-dimensional axisymmetric computational plane. From results of the numerical calculation it can be shown that the vortex zone appears when a magnetic field is applied and the configuration of flow associated with the vortex zone changes for variation in the magnetic field, increasing or decreasing the heat transport capability dependent upon the conditions of the device.
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46

Shafiq, Muhammad, Maqbool Ahmad, Muhammad Khalil Afzal, Amjad Ali, Azeem Irshad e Jin-Ghoo Choi. "Handshake Sense Multiple Access Control for Cognitive Radio-Based IoT Networks". Sensors 19, n. 2 (10 gennaio 2019): 241. http://dx.doi.org/10.3390/s19020241.

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Abstract (sommario):
Internet-of-Things (IoT) enabling technologies such as ZigBee, WiFi, 6LowPAN, RFID, Machine-to-Machine, LTE-Advanced, etc. depend on the license-free Industrial Scientific and Medical (ISM) bands for the Internet. The proliferation of IoT devices is not only anticipated to create a huge amount of congestion in the near future, but even now the unlicensed spectrum is not enough in the ISM bands. Towards this end, Cognitive Radio (CR) technology can resolve the spectrum shortage issue since CR users can opportunistically exploit white spaces in licensed channels of the adjacent wireless systems. In CR networks, it is critical to coordinate spectrum access among Secondary Users (SUs) while protecting priority rights of Primary Users (PUs). Therein, SUs need to take good care of hidden PUs in order to avoid harmful interference. Further, a densely deployed CR network can compromise spectrum sensing quality and certainty of the results when a large number of SUs contends to access the same channel. Therefore, based on the vulnerable sensing results, SUs can cause interference to the PUs. In this paper, we first investigate the leading issues and then propose a novel Handshake Sense Multiple Access with Collision Avoidance (HSMA/CA) protocol for CR-based IoT networks. Our proposed HSMA/CA scheme resolves hidden primary terminal problem and maintains sufficient priority rights to PUs in a densely distributed network. In addition, we optimize the spectrum sensing period to maximize the system performance by maintaining peculiarities in the sensing operation like false alarm and misdetection. To evaluate the performance of HSMA/CA, we have analyzed the protocol through the Markov chain model in terms of throughput and verify its accuracy by simulations. Simulation results show that our scheme is suitable for non-collaborative densely deployed CR-based IoT networks.
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47

USHIJIMA, Satoru, e Yohei OKUYAMA. "COMPARISON OF C-HSMAC AND SOLA METHODS FOR PRESSURE COMPUTATION OF INCOMPRESSIBLE FLUIDS". Doboku Gakkai Ronbunshu, n. 747 (2003): 197–202. http://dx.doi.org/10.2208/jscej.2003.747_197.

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48

Park, Kyung Hwa, Sun A. Kim, Sung Pil Hong, Hye Won Chung, Seung Woo Park, Jae Bock Chung, Han Soo Kim e Si Young Song. "Mutation of mitotic spindle checkpoint gene, hsMAD2 but not hBubl, is common in gastric cancer and dysplasia". Gastroenterology 124, n. 4 (aprile 2003): A295. http://dx.doi.org/10.1016/s0016-5085(03)81484-1.

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49

Dey, Sanjit, Veedamali S. Subramanian, Nabendu S. Chatterjee, Stanley A. Rubin e Hamid M. Said. "Characterization of the 5′ regulatory region of the human sodium-dependent multivitamin transporter, hSMVT". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1574, n. 2 (marzo 2002): 187–92. http://dx.doi.org/10.1016/s0167-4781(02)00226-9.

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50

Liang, Jiuyang, Jiaxing Yuan e Zhenli Xu. "HSMA: An O(N) electrostatics package implemented in LAMMPS". Computer Physics Communications 276 (luglio 2022): 108332. http://dx.doi.org/10.1016/j.cpc.2022.108332.

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