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1
Zhu, Yumei, e August Österle. "China's policy experimentation on long-term care insurance: Implications for access". Wiley, 2019. http://dx.doi.org/10.1002/hpm.2879.
Abstract (sommario):
China's population is aging rapidly, while the traditional long-term care (LTC) system that heavily relies on families is eroding. In response, China has embarked on a journey of policy experimentation for long-term care insurance (LTCI) since 2016, launching LTCI pilots in 15 pioneer cities. These pilots have a great diversity in participation, eligibility, and provision. This paper estimates the prevalence of LTC needs and analyzes the impact of the LTCI pilots on access. Although substantial progress has been achieved, the overall coverage of LTCI is still relatively small, and a large proportion of vulnerable people needing LTC seem to be left behind because of the strict eligibility criteria. This analysis suggests that future policy experimentation on LTCI reform in China needs to address the following pressing policy issues: expanding the coverage of LTCI; narrowing rural-urban disparities in access; improving access for vulnerable subpopulations; and reducing the heavy reliance on institutional care.
2
Eriksson, Kjell. "HPM-vapen vs. kommersiell UAV". Thesis, Försvarshögskolan, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-6273.
Abstract (sommario):
Detta arbete i militärteknik studerar om högeffektpulsad mikrovågsstrålning kan uppnå verkan mot kommersiella UAV. Analysen genomförs på två olika icke-dödliga HPM-vapen. Data hämtas från ett scenario där vapenverkan innebär hög risk för skada på tredje man. En Försvarsmaktsstudie har konstaterat att Luftvärnsbataljon saknar förmåga att verka mot små UAV.Dagsaktuell kunskap har inhämtats om scenariots miljö samt från forskning och industri genom studiebesök. Inhämtad kunskap har möjliggjort en logisk-matematisk parameterstudie på ett scenario med militärtekniskt perspektiv. Analysens slutsatser är att kommersiella UAV innehar låg skyddsnivå, att beslut om insats underlättas i alla miljöer och att en elektronisk sköld i form av HPM-vapen skyddar en stor volym samtidigt. HPM-vapen kan inte som ensamt vapensystem stå för skydd och uppnå säkerställd verkan mot kommersiell UAV. HPM-vapen kan däremot komplettera övriga verkanssystem och göra luftförsvaret starkare genom system av system. HPM-vapen kan bidra till att minska ett befintligt förmågeglapp mot kommersiella UAV.This paper in military technology discusses whether high power microwaves can affect commercial UAVs. Two non-lethal HPM-weapons are analyzed. The data is collected from a scenario where there is a high risk for collateral damage. A Swedish Armed Forces study stated that the Air Defence Battalion lacks ability to affect small UAVs. The latest knowledge is obtained from the environment in the scenario, from research and from the industry. This knowledge has enabled a logical-mathematical parametric study on the scenario within a military perspective. The result of the study is the assessment that commercial UAVs are assessed to have low protection factor, facilitates decision to act in all environments and provides an electronic shield protection of a large surface at the same time. HPM-weapons can´t stand as a single system for protection against commercial UAVs and achieve guaranteed effect. However, HPM-weapons can complement other weapon systems and thus make the air defense stronger through systems of systems. HPM-weapons can reduce the capability deficiency against commercial UAVs.
3
Kreitlow, Matthias [Verfasser]. "Analyse von HPEM-Störungseffekten in Computer-Netzwerken / Matthias Kreitlow". Düren : Shaker, 2019. http://d-nb.info/1196487332/34.
4
Lanzrath, Marian [Verfasser], e Holger [Akademischer Betreuer] Hirsch. "HPEM-Verwundbarkeit des Smart Grid / Marian Lanzrath ; Betreuer: Holger Hirsch". Duisburg, 2020. http://d-nb.info/1216038899/34.
5
Narahara, Sheryl K. "Occupational narratives of human performance technology (HPT)". [Bloomington, Ind.] : Indiana University, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3329712.
Abstract (sommario):
Thesis (Ph.D.)--Indiana University, Dept. of Instructional Technology, 2008.Title from PDF t.p. (viewed on Jul 19, 2010). Source: Dissertation Abstracts International, Volume: 69-10, Section: A, page: 3919. Adviser: Thomas Schwen. Includes supplementary digital materials.
6
Wessman, Thomas. "HPM som luftvärnsvapen mot kryssningsmissiler, en möjlighet?" Thesis, Försvarshögskolan, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-1640.
Abstract (sommario):
I denna uppsats undersöks huruvida HPM (High Power Microwaves) kan användas som enverkansform i framtida luftvärnssystem för att bekämpa kryssningsmissiler. Studien undersökervilket hot kryssningsmissiler kan utgöra, hur de är konstruerade och hur HPM kan påverka dem.Uppsatsen redogör för hur det nya luftvärnskonceptet är uppbyggt och vilka krav på förmågor somställs på framtida luftvärnssystem. Den undersöker även hur ett HPM-system är uppbyggt ochvilken verkan det kan ha på elektriska system i en kryssningsmissil. Vidare diskuteras vilkeneffekt tre olika HPM-system kan ha mot kryssningsmissiler kopplat till de krav som ställs iluftvärnskonceptet.Huvudslutsatsen indikerar att HPM-system kan ha verkan mot kryssningsmissiler. HPM-systemkan nyttjas främst i scenarier där det ställs höga krav på eldhastigheten mot kryssningsmissiler påkorta avstånd. Ett problem är att det är svårt att utvärdera och konstatera skadeeffekten ikryssningsmissilen.Avdelning: ALB - Slutet Mag 3 C-uppsHylla: Upps. ChP T 03-05
7
SILVA, Tatiane Sousa. "Planejamento em saúde: interação entre gestores & usuários no HPSM Mário Pinotti". Universidade Federal do Pará, 2011. http://repositorio.ufpa.br/jspui/handle/2011/2961.
Abstract (sommario):
Submitted by Ana Rosa Silva (arosa@ufpa.br) on 2012-09-13T16:01:52Z
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Planejar em Saúde não é um tema que se restrinja a uma única matriz disciplinar. Para tratá-lo é necessário buscar em diversas áreas do conhecimento numa perspectiva “transdisciplinar”. Nesta pesquisa tentarei compreender e assimilar novas formas de gestão na saúde para o HPSM Mario Pinotti (Belém-Pará) que não estejam, em sua essência, apenas representando uma capitulação diante de uma conjuntura difícil, ou em outras palavras sucumbindo diante das dificuldades atuais dos problemas advindos de uma sociedade moderna e com interesses tão múltiplos quantos seus atores. Partimos da manifestação da necessidade de proximidade entre as pessoas, no contexto da humanização da relação de pesquisa, requer uma postura de valorização da vida acima de qualquer processo estrutural e/ou técnicocientífico. Por esse motivo escolhemos Bourdieu como principal referência para uma pesquisa etnográfica em um ambiente micropolítico, sob a perspectiva do estabelecimento de uma relação compreensiva com os atores sociais atuantes. Esta opção metodológica é fundamental para a compreensão do objeto proposto, o que dificilmente pode ser feito a partir da escolha de procedimentos simplificados, tais como entrevistas padronizadas e pontuais. O que se abstraiu dos resultados desta pesquisa é que existe um anseio por parte dos gestores e profissionais em adequar a demanda do hospital à capacidade do hospital e não o contrário. Entretanto, é necessário que haja um equilíbrio entre ambos para que o planejamento atinja o objetivo proposto que é o de ordenar os recursos financeiros e humanos com máxima eficiência possível. Políticas e estratégias devem ser consideradas sob a égide de um planejamento participativo promovendo um diálogo entre os que dependem do sistema e trabalham no/para o sistema.
Make plans in the area of health is not an issue that is confined to a single disciplinary matrix. To treat it is necessary to look at different areas of knowledge from a "transdisciplinary" perspective. In this research I will try to understand and assimilate new forms of management in health for HPSM Mario Pinotti (Belém-Pará) that it's not in its essence, merely representing a capitulation to a difficult economic situation, or in other words, succumbing before the current difficulties of the problems arising from a modern society with interests such as multiple than their actors. We started from need for proximity between people, in the context of the humanization of the relationship of research requires an attitude of valuing life above any structural process and / or technical-scientific. For this reason we chose as the main reference to Bourdieu's ethnographic research in an environment micro political from the perspective of establishing a comprehensive relationship with social actors acting. This methodological approach is fundamental to understanding the proposed object, which can hardly be made from the choice of simplified procedures like punctual interviews. What is abstracted from the results of this research is that there is a yearning on the part of managers and professionals in adapting to the demands to the hospital capacity of the hospital and not vice versa. However, there must be a balance between both that the proposed design achieves the goal that is the sort of financial and human resources with maximum efficiency possible. Policies and strategies must be considered under the aegis of a participatory planning by promoting a dialogue between those who depend on the system and work in / for the system.
8
Rosales, Marc. "Study of SiGe HPT for radio over fiber applications". Thesis, Paris Est, 2014. http://www.theses.fr/2014PEST1101/document.
Abstract (sommario):
Ce travail de thèse présente le développement de phototransistors bipolaires à hétérojonction (HPT) SiGe/Si mis en œuvre dans une technologie de processus 80GHz SiGe bipolaire pour des applications de transmission Radio-sur-Fibre. Le cas particuliers d'un réseau domestique sans fil à infrastructure optique est considéré pour lequel le critère de coût est prépondérant. Le fonctionnement des ce HPT SiGe/Si est étudié sous une longueur d'onde optique de 850 nm en exploitant des fibres optique multimode (MMF) suffisantes pour les besoins de bande passante dans un environnement de réseau domestique. Le HPT SiGe/Si est également développé dans l'objectif de permettre une intégration combiné du photorécepteur et circuit intégré monolithiquement, conduisant à des structures de type Opto-electronic Microwave Monolithically Integrated Circuit (OE-MMIC), visant à poursuivre l'intégration et la réduction des cours. Deux topologies ont été explorées principalement: 1) une topologie avec élargissement de la base et du collecteur (xBC HPT) et 2) une topologie avec élargissement des trois régions de base, émetteur et collecteur simultanément (xEBC HPT). Des variations technologies ont été réalisées et analysées en détail, à la fois en terme de couches verticales que de dessin de masque (layout). Les mesures ont démontré la validité technologique de chacune de ces approches, et permis d'isoler l'impact sur les performances statiques et dynamiques de chacune de ces couches. Une solution de type xEBC se montre ainsi préférable pour le cas de composants de petites dimensions inférieure à 50x50µm², dans la bande du GHz. Les phototransistors sont développés dans une configuration à trois terminaux (3T-HPT). Le type de polarisation de la base du HPT influe également sur la responsivité du phototransistor. Une polarisation de courant constant (CC) démontre une plus grande responsivité par rapport au cas d'une polarisation en tension ( CV). Une analyse détaillée montre aussi les différences de responsivité mesurées en continue et celles mesurées en basse fréquence à 50MHz. La connexion de base permet également de varier l'impédance de charge présentée sur celle-ci. La théorie de l'adaptation des phototransistors est rappelée. L'effet de différentes impédances de base sont étudiées par la simulation et la mesure des circuits réalisés technologiquement. L'intégration du phototransistor au sein d'un circuit élémentaire est enfin explorée. Différentes configurations de paires HPT - HBT sont étudiées, formant des circuits élémentaires. Des caractérisations expérimentales permettent de vérifier l'amélioration apportées par ces topologies par rapport au phototransistor unique. Enfin, un phototransistor SiGe en configuraiton 2T-HPT est utilisé et intégré avec succès pour la première fois au sein d'un module de type Receiving Optical Sub Assembly (ROSA) pour la mise au point d'une transmission Radio-sur-Fibre multiGigabit par seconde pour un réseau domestiqueThis research is focused on the study of silicon germanium based heterojunction bipolar phototransistors (SiGe HPTs) implemented in an 80GHz SiGe Bipolar process technology. It's application in a radio over fiber system for home area networks are investigated. RoF for Home area networks are envisioned to implemented with a minimal system cost. Operation at 850nm is identified as a critical parameter to achieve this goal. Low cost off the shelf optical components are readily available at this wavelength. The use of multi mode fibers (MMF) as opposed to higher cost single mode fiber (SMF) is sufficient for the bandwidth requirements in a home network environment. A monolithically integrated OE receiver chip would help in the overall reduction of the system cost by having the optical detector in the same chip with the electronic circuits. We have designed and implemented three terminal HPT (3T-HPT) structures. The two main groups of the HPT structures are: 1) HPTs with extended Base and Collector regions (xBC HPT) and 2) HPTs with extended Emitter, Base and Collector regions (xEBC HPT). Variations to improve optical coupling the though optimizations in the vertical stack and lateral size of the HPT. The measurements and characterization showed that all the structures are compatible with the process technology. The type of biasing used in the base of the HPT also influences the HPT performance. A constant current (CC) bias has higher extracted DC responsivity as compared to a constant voltage (CV) bias. The effects of the different passive base loads on the HPT responsivity are studied through simulation and measurement of fabricated circuits. The impedance presented on the base has a great influence on the HPT responsivity. The performance of an HPT as circuit component is studied using different HPT-HBT pair configurations. Tests and measurements verify that improvement in the classical transistor pair configurations are also present in the opto microwave response of the HPT-HBT pair. Finally, SiGe hpt is used in the development of a ROSA module for a radio over fiber systems for home area network
9
Arzaghi, Mandana. "Nouveau procédé d'hyperdéformation pour les tubes". Thesis, Metz, 2010. http://www.theses.fr/2010METZ031S.
Abstract (sommario):
La nouvelle technique d'hyperdéformation nommée High Pressure Tube Twisting (HPTT), est un procédé continu d'affinement du grain pour les matériaux métalliques avec la géométrie tubulaire. Il consiste à placer un mandrin dans le tube avant d'appliquer une compression axiale directement sur le tube confiné des deux côtés pour produire une pression hydrostatique importante. Le tube est ensuite cisaillé par un couple externe à l'aide de la force de frottement généré par la pression hydrostatique. Les structures ultrafines produit avec HPTT ont été confirmés par MET et leur propriétés mécaniques ont été évaluées. La limite d'élasticité est augmentée de façon monotone avec la déformation imposée par HPTT. L'évolution de la microstructure est étudiée par la technique EBSD et les mesures de texture ont été réalisées avec des rayons X. Les échantillons déformés ont la texture de cisaillement simple, avec des intensités relativement faibles et l'effet de la texture initiale sur la texture finale persiste jusqu'à un cisaillement de 6. La distribution des désorientations entre les grains est bimodale et le second pic augmente avec la déformation. Application industrielle de cette nouvelle technique SPD exige la modélisation avancée en termes d'évolution de texture et le processus de fragmentation des grains. Dans ce but, le nouveau modèle de fragmentation du grain proposé par Toth et al. a été utilisée. L'affinement du grain améliore les résultats de simulation texture de façon significative et donne des informations complémentaires sur la distribution et la taille moyenne des grains, et la distribution de désorientation qui peut être directement comparés aux résultats expérimentauxThe new severe plastic deformation (SPD) technique, designated as high pressure tube twisting (HPTT), is a continuous process for grain refinement in bulk metallic materials with tubular geometry. It consists of placing a mandrel into the tube before applying an axial compression directly on the tube confined on both sides to produce high hydrostatic pressure. The tube is then twisted by an external torque with the help of the friction force genrated by the hydrostatic pressure. The ultra-fine grained structures produced with HPTT were confirmed using transmission electron microscopy and their microstructure and mechanical properties were evaluated. The value of yield stress is increased monotonically with the deformation imposed by HPTT. Meanwhile, the inverse deformation path is proved to be less advantageous. Microstructural evolution is studied by EBSD technique and texture measurements were carried out using X-ray. Deformed samples have simple shear texture with relatively low intensities and the effect of the initial texture on the final texture persists up to shear strain of nearly 6. Grain-to-grain misorientation distribution functions are bimodal and the second pick become higher with increasing strain. Industrial application of this new SPD technique requires advanced modelling in terms of texture evolution and grain fragmentation process. For this purpose, the new grain refinement model proposed by Toth and al. was used. Grain refinement improves the texture simulation results significantly and gives information on the average grain size, grain size distribution and misorientation distribution function that can be directly compared to experimental results
10
Nilsson, Tony. "Investigation of Limiters For HPM and UWB Front-door Protection". Thesis, Linköping University, Department of Electrical Engineering, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7836.
Abstract (sommario):
An extensive investigation of front-door protection devices i.e. limiters has been made. The thesis work contains both HPM- and UWB-measurements done on various limiters, in order to characterize them. The measurements show that all limiters are not suitable as protection against HPM- and UWB-pulses. The limiters that were found to provide the best protection are limiters based on diode technologies. PIN- and Schottky-diodes generally shows very good performance and they fulfill many parameters that have been set by FOI. To obtain a full protection it is presumably necessary to use two or more limiters in combination, which complement each other.
En omfattande studie av framvägskopplingsskydd, dvs. limiters har gjorts. Examensarbetet innehåller resultat från både HPM- och UWB- mätningar som har gjorts på olika limitrar för att karaktärisera deras prestanda. Av resultaten från mätningarna kan man se att alla limitrar inte passar som skydd mot HPM- och UWB-pulser. De limitrar som tillhandahöll det bästa skyddet var baserade på olika diodtekniker. PIN- och Schottky-dioder visade sig överlag ha väldigt goda prestanda och de uppfyller många av de parametrar som bestämts av FOI. För att få ett heltäckande skydd är det förmodligen nödvändigt att man använder två eller flera limitrar i kombination, som kompletterar varandra.
11
Klint, Andreas. "En ny motmedelsprincip : Kan HPM användas som motmedelssystem för helikopterplattformar?" Thesis, Försvarshögskolan, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-6758.
Abstract (sommario):
Denna studie undersöker ifall man i framtiden skulle kunna använda High Power Microwaves (HPM) som skyddssystem på helikopterplattformar. Skulle HPM kunna slå robotsystem på det elektroniska djupet istället för att avhaka eller blända hotsensorn, vilket idag görs med hjälp av facklor eller remsor. Uppsatsen beskriver funktion och ingående komponenter för HPM-konstruktioner, olika verkansformer samt skydd mot elektromagnetisk strålning. En beskrivning av hotrobotars olika delar och hur HPM påverkar dess funktioner ges. Ett scenario utarbetas för att skapa ett fast utgångsläge för SWOT-analys och beräkningar av ett HPM-baserat motmedelssystem. Scenariot är gjort för att skapa sämsta tänkbara läge för en helikopterplattform. Uppsatsen jämför även HPM-teknik med Directed Infrared Counter Measures (DIRCM), vilket är ett relativt nytt elektrooptiskt motmedel för skydd av helikoptrar mot IR-robotar. Efter jämförelsetabell och SWOT-analys forstätter studiens fokus vara HPM. Slutsatsen visar att det, av vikt-, volym-, uteffekt- och tidsskäl i en nära framtid inte lämpar sig att slå robotsystem på det elektroniska djupet för att skydda en mindre helikopterplattform mot hotrobotar. HPM- system lämpar sig däremot väl för rörligare större plattformar som TP84. HPM-teknik på helikopter visar sig emellertid kunna nyttjas som verkans- och Understödssystem för skydd av större geografiskt område, vid förflyttning eller som telekrigsunderstöd av markförband, vilket möjliggörs av helikopterns höga rörlighet.
12
Puleio, Francesco. "An Innovative Synchronization Technique for OpMiGua-based Mobile Backhauls : The IEEE 1588v2 HPTS Scheme". Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for telematikk, 2010. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-11129.
Abstract (sommario):
Legacy mobile backhauls are based on Time Division Multiplexing. Due to the current evolving of mobile traffic, a major change to a packet-based network is seen as inevitable. This means that the TDM signal cannot be used as source of synchronization anymore. The packet-layer based approach of the IEEE 1588v2 protocol has experienced a successful diffusion, while the physical-layer based solution of Synchronous Ethernet is still under development.A new packet-based synchronization technique is presented along this thesis. It is based on applying the OpMiGua HPTS scheme over a mobile backhaul that is structured into a cluster-type topology. The proposed technique has been given the name of IEEE 1588v2 HPTS scheme. It consists of exchanging timestamps according to the synchronization algorithm standardized into the IEEE 1588v2 protocol but exploiting the switching capabilities of the OpMiGua HPTS node. Differently from the IEEE 1588v2 protocol, our scheme foresees the timestamps to be preprended to the train of time-slots traveling throughout each ring (i.e. the fundamental element of the cluster-type network topology). The presence of time-slots is due to the adoption of the OpMiGua HPTS scheme. Thanks to the hybrid switching capabilities of the OpMiGua HPTS node, it is assured a fixed end-to-end delay to the timestamps. Work done consists of proposing a structure for the OpMiGua HPTS node, allowing to forward and duplicate for processing the timestamps in the same time, and the format of all the messages foreseen into the new scheme. A header format is presented as well as the framing for the messages containing the timestamps. This is applied over the cluster-type topology since the latter is identified as a more suitable physical layer configuration compared to the tree structure of legacy backhauls.The proposed technique is able to improve the accuracy achievable, since the timestamps are made independent from the traffic load into the nodes. Also a saving in terms of bandwidth consumption is provided.
13
Nwulu, Equi Emmanuel. "Utility of the HPT Framework for Improving Distance Education in Nigeria". Thesis, Walden University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10687499.
Abstract (sommario):
The fusion of the Internet with instructional design, and curricula delivery methods eliminated transactional distance in online learning. However, distance education (DE) in Nigeria has not aligned its pedagogy to the new reality in technology. The purposes of this non-experimental, predictive, validity study were to determine faculty and administrators’ perceived barriers and concerns to online adoption and to validate the behavior engineering model (BEM) instrument. Ninety-six respondents from four public universities in Nigeria completed the questionnaires. Descriptive statistics and structural equation modeling (SEM) were used respectively, to assess barriers and concerns militating against faculty and administrators’ online adoption, as well as validate the survey instruments. For faculty and administrators, incentive, motive, knowledge and skills influenced DE adoption. Except for age, all demographic factors influenced faculty’s concerns. Gender was observed to influence administrators’ concern. “Level of online use” influenced neither faculty nor administrators’ concerns. Technographic characteristics influenced faculty, but not administrators.’ Though the BEM instrument was reliable in measuring faculty and administrator’s stages of concern, however, the 6-factor BEM, tested at the 95% significant level, did not give a good fit. The study contributes to positive social change by identifying gaps to effective DE implementation, and recommended the appropriate interventions to transform the DE experience for students and their universities. The study also proposed the framework to fast track Nigeria’s vision and mission for DE.
14
Poloprudský, Jakub. "Struktura a mechanické vlastnosti materiálů na bázi hořčíku zpracovaných metodou HPT". Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-400834.
Abstract (sommario):
This thesis is focused on processing of pure magnesium by high pressure torsion method (HPT). This process belongs to the group of intensive plastic deformation methods (SPD). SPD methods are in the centre of scientific interest for several decades. Theoretical part of this thesis puts an effort to summarize basic knowledge and principles of SPD methods with extra focus on method HPT. As theoretical part continues magnesium as technical material is presented. Influence of SPD on use and properties of pure magnesium is then presented. This trend is further developed in effort to describe the effect of individual HPT process variables on the properties of pure magnesium and its alloys. Focus of practical part of this thesis is in influence of number of revolutions. Samples were processed at 1/8, 1/4, 1/2, 1, 4 and 8 turns at room temperature. Speed of process was 1rpm and applied pressure was 6 GPa. The structure of commercially pure magnesium prepared by casting and moulding were observed with focus on differences caused by input material. The structure was observed by both light microscopy and back scattered electron diffraction (EBSD), focusing on structure development, grain size and grain orientation. Compared to other works on similar topic, the emphasis here is on observing the microhardness on the vertical edge of the sample. The hardness shows a steep increase right after 1/8 of a turn. With increasing number of turns gradual homogenization of microhardness is presented accompanied by slight decrease in microhardness. No trend in microhardness relative to the distance from anvil has occurred. Structure observed with EBSD shows a bimodal character with larger grains oriented in the same direction. The three-point bending test didn’t end up as expected, and the approach to evaluation of magnesium-based HPT needs to be re-evaluated for future work. A three-point bending test was designed for the initial assessment of the basic mechanical properties of the material.
15
Nwulu, Equi. "Utility of the HPT Framework for Improving Distance Education in Nigeria". ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/4663.
Abstract (sommario):
The fusion of the Internet with instructional design, and curricula delivery methods eliminated transactional distance in online learning. However, distance education (DE) in Nigeria has not aligned its pedagogy to the new reality in technology. The purposes of this non-experimental, predictive, validity study were to determine faculty and administrators' perceived barriers and concerns to online adoption and to validate the behavior engineering model (BEM) instrument. Ninety-six respondents from four public universities in Nigeria completed the questionnaires. Descriptive statistics and structural equation modeling (SEM) were used respectively, to assess barriers and concerns militating against faculty and administrators' online adoption, as well as validate the survey instruments. For faculty and administrators, incentive, motive, knowledge and skills influenced DE adoption. Except for age, all demographic factors influenced faculty's concerns. Gender was observed to influence administrators' concern. "Level of online use" influenced neither faculty nor administrators' concerns. Technographic characteristics influenced faculty, but not administrators.' Though the BEM instrument was reliable in measuring faculty and administrator's stages of concern, however, the 6-factor BEM, tested at the 95% significant level, did not give a good fit. The study contributes to positive social change by identifying gaps to effective DE implementation, and recommended the appropriate interventions to transform the DE experience for students and their universities. The study also proposed the framework to fast track Nigeria's vision and mission for DE.
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CINQUE, LUIGIA. "Multi-integrated approach based on HPT-JT families for the identification of a set of biomarkers of Parathyroid Carcinoma". Doctoral thesis, Università di Foggia, 2018. http://hdl.handle.net/11369/369205.
Abstract (sommario):
Introduzione. Nella sindrome da iperparatiroidismo associato a tumore della mandibola (HPT-JT), il carcinoma paratiroideo (PC) è causato da mutazioni del gene oncosoppressore CDC73 codificante per parafibromina, un componente del complesso PAF1 coinvolto nel rimodellamento della cromatina e nella regolazione del ciclo cellulare. Le mutazioni del gene MEN1 causano la sindrome omonima (MEN1), le cui lesioni paratiroidee sono benigne nel 99% dei casi ma, negli ultimi 40 anni, sono stati riportati 15 casi di associazione insolita fra PC e la sindrome MEN1 nel mondo. Il PC è un tumore raro e aggressivo per il quale le attuali terapie sono risultate inefficaci e l'asportazione chirurgica della lesione rimane l'unico approccio curativo. Tuttavia, la distinzione in prima diagnosi fra una lesione paratiroidea maligna e un’ iperplasia indolente o un’adenoma benigno rappresenta ancora oggi una sfida, in assenza di segni patognomici, come metastasi a distanza o recidive locali. Finora, sono stati compiuti sforzi infruttuosi per la ricerca di biomarcatorimolecolari che potessero indirizzare verso il (migliore) trattamento chirurgico (conservativo/demolitivo) al fine di ridurre il rischio di recidiva e di estendere la sopravvivenza libera da malattia. Scopo del progetto e metodi. Questo progetto mira a identificare le cause genetiche che portano allo sviluppo di un carcinoma paratiroideo (PC) e a individuare una serie di biomarcatori utili per una inequivocabile e precoce diagnosi di PC. A tal fine sono state applicate strategie di Next Generation Sequencing, quali il sequenziamento dell’ intero esoma e studi di espressione genica, a casi familiari (costituiti da uno o più soggetti affetti, portatori non affetti e controlli sani con lo stesso background genetico) piuttosto che a casi sporadici al fine di ridurre, per quanto possibile, la variabilità intrinseca causata dai diversi background genetici. La nostra rara coorte consta di 5 famiglie con HPT-JT e lesione paratiroidea maligna e mutazione costituzionale del gene CDC73 e una famiglia molto rara con mutazione MEN1 associata a PC. Risultati. Il sequenziamento dell’intero esoma ha mostrato che solo i soggetti affetti di 4 (delle 5) famiglie con HPT-JT reclutate per lo studio, condividono varianti rare (MAF <0,004) in geni codificanti per le integrine (ITGA3, ITGA2B, ITGA11, ITGAB6, ITGA9), recettori di superficie coinvolti nell'adesione cellulare alla matrice extracellulare (ECM) ed essenziali per la proliferazione, la sopravvivenza, l'adesione e la migrazione delle cellule. Inoltre sono state identificate ulteriori varianti nei geni che codificano per proteine coinvolte nel riparo del DNA come FANCC e BRIP1; NOTCH4; RET; BRCA1; BLK; MUC12; KMT2C; geni target della pathway di Hedgehog quali SMO, GLI3, mentre una variante del gene GLI2 è stata identificata solamente nei soggetti affetti della famiglia MEN1 associata a PC. Lo studio dell’ espressione genica è stato condotto confrontando i pazienti affetti vs controlli fra le famiglie con HPT-JT e l'unica famiglia MEN1-PC. L’ analisi effettuata ha mostrato un'espressione differenziale dei geni del sistema immunitario e inoltre ha evidenziato che i pazienti MEN1 e HPT-JT utilizzano diversi set di geni per controllare la mobilizzazione del calcio. Saggi funzionali. Cellule HEK293 sono state trasfettate con vettori di espressione codificanti la forma WT o mutata del gene CDC73: sono state testate 5 diverse mutazioni in presenza/assenza di Bortezomib, un farmaco già utilizzato in clinica per la terapia del mieloma multiplo. Questo inibitore del proteasoma sembra essere in grado di recuperare parzialmente l'espressione di proteine CDC73 mutate a causa di mutazioni missenso, in-frame e persino frameshift. Conclusioni e prospettive. Questo progetto, seppur preliminare, può aiutarci ad identificare biomarker utili per una diagnosi precoce e immediata di PC al fine di indirizzareverso il miglior approccio chirurgico e identificare i portatori asintomatici nelle famiglie affette per un intervento precoce ed efficace. Ipotizziamo che l'insorgenza/progressione/aggressività del PC possa essere dovuta alla deregolazione di proteine coinvolte nell'adesione cellula-cellula (come le integrine); allo squilibrio nell’ attivazione del sistema immunitario; alla deregolazione della pathway di Hedgehog e alla perdita di fattori scatenanti, come le proteine implicate nel mantenimento dell'integrità del DNA (FANCC, BRIP1, BRCA1). Infine, considerando che la ricerca di un farmaco efficace come approccio alternativo al trattamento chirurgico è risultata fino ad oggi vana, per la prima volta, riportiamo il possibile utilizzo di un farmaco chemioterapico ben conosciuto, il Bortezomib, per la terapia del PC dovuto a mutazioni del gene CDC73.Background. As part of the Hyperparathyroidism with Jaw Tumor syndrome (HPT-JT), parathyroid carcinoma (KP) is caused by mutations of the CDC73 tumor suppressor gene, encoding the parafibromin, a PAF1 co-transcription factor, involved in chromatin remodelling and cell cycle regulation. Mutations of MEN1 gene cause the namesake syndrome (MEN1), in whose parathyroid lesions are benign in 99% of cases: instead, in the last 40 ys, only 15 cases worldwide have been reported with the unusual association of KP in MEN1 syndrome. KP is a rare, aggressive life-threatening tumor for whose at the present current therapies resulted ineffective and the surgical removal of the lesion remains the only curative approach. However, to recognize in first diagnosis a malignant parathyroid lesion from an indolent hyperplasia or benign adenoma still represents a challenge, in absence of pathognomic signs, such as distant metastasis or local recurrences. So far, unsuccessful efforts have been made in search of clinical biomarkers that could address to the (best) surgery option (conservative/demolitive) in order to reduce the risk of recurrence and to extend the disease free survival. Purpose and methods. The present project aims to identify the genetic causes leading to the development of a parathyroid carcinoma (KP) and to detect a set of biomarkers for a possible unequivocal, early first diagnosis. We decided to apply high throughput strategies such Whole Exome Sequencing (WES) and Expression Profiling (EP) to familial cases (consisting of one or more affected subjects, non-affected carriers and healthy controls with the same genetic background) rather than to sporadic ones in order to, possibly, reduce the intrinsic variability caused by different genetic backgrounds. Our rare cohort consisted of 5 HPT-JT families with malignant parathyroid lesion and constitutional mutation of the CDC73 gene and a very rare family with MEN1 mutation associated with recurrent and familial KP. Results.WES analysis revealed that in 4 (out of 5) HPT-TJ families, surprisingly, only the affected subjects shared rare variants (MAF < 0.004) in genes encoding the integrins (ITGA3, ITGA2B, ITGA11, ITGAB6, ITGA9), cell surface receptors involved in cell adhesion to the extracellular matrix (ECM) and essential for proliferation, survival, adhesion and migration of cells. Moreover, other variants in genes encoding proteins involved in DNA repair such as FANCC and BRIP1; NOTCH4; RET; BRCA1; BLK; MUC12; KMT2C; Hedgehog target genes such as SMO, GLI3 were identified. Finally a variant in GLI2 gene was found inaffected subjects of MEN1- KP family. The EP analysis compared the affecteds vs controls between HPT-JT families and the unique MEN1-KP family. The analysis showed a differential expression of genes of immune system. The EP also evidenced that MEN1 and HPT-JT patients use different set of genes to control the calcium mobilization. Functional assay. Human embryonic kidney (HEK293) cell lines were transfected with eukaryotic expression vectors carrying WT or mutated CDC73 gene: 5 different mutations weretested in presence/absence of Bortezomib, a drug already used in clinic for the therapy of multiple mieloma. We proved that this proteasome inhibitor was able to partially rescue the expression of missense, inframe and even frameshift CDC73 gene deletions. Conclusions and perspectives. This preliminary project may help to find a biomarkers set for a prompt early diagnosis of KP, in order to suggest the best surgical approach and identify asymptomatic carriers in affected families for an efficient early intervention. We suppose that the onset/progression/aggressivity of KP may be due to the deregulation of proteins involved in cell-cell adhesion (such integrins); the derangement of immune system; the deregulation of the Hedgehog pathway and the lack of trigger factors, such as the proteins assigned to DNA integrity (FANCC, BRIP1, BRCA1). Finally we reported, for the first time, the possible use of a well known chemotherapy drug, the Bortezomib, for the therapy of KP CDC73 induced, taking into account that, so far, all the attempts to find an efficient drugs as alternative approach to the surgery, resulted ineffective.
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Tränkner, Christine. "Mikrostruktur- und Texturentwicklung während massiver plastischer Verformung von NiAl bei tiefen Temperaturen". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230717.
Abstract (sommario):
NiAl ist eine intermetallische Verbindung mit kubischer B2-Struktur. Unterhalb der Spröd-duktil-Übergangstemperatur, die bei Normaldruck bei etwa 300°C liegt, können nach dem Von-Mises-Kriterium nicht ausreichend viele unabhängige Gleitsysteme zur homogenen plastischen Verformung aktiviert werden, da die Bruchspannung unterhalb der kritischen Schubspannung zur Aktivierung des sekundären Gleitsystems liegt. Um NiAl trotzdem massiv plastisch verformen zu können, muss die Verformung bei hohem Druck erfolgen. Dies ist beispielsweise möglich bei der Verformung mittels Gleichkanal- Winkelpressen (ECAP) oder Hochdrucktorsion (HPT). Hierbei werden sehr hohe Verformungsgrade erreicht. In dieser Arbeit wird nun die Gefüge- und Texturentwicklung bei Verformung mittels HPT bei Temperaturen zwischen Raumtemperatur und 500°C in Abhängigkeit von Temperatur und hydrostatischem Druck sowie Verformungsgrad untersucht und mit den entsprechenden Größen bei der Verformung mit ECAP verglichen. Es zeigt sich, dass bei der HPT-Verformung die für kubisch-raumzentrierte Metalle typische Schertextur auftritt; zudem findet sich ab einer Verformungstemperatur von 100°C eine geneigte Würfellage, die durch dynamische Rekristallisation entstanden ist und deren Intensität mit der Verformungstemperatur ansteigt. Auch bei den ECAP-Proben findet man die typische Schertextur, eine Würfeltextur tritt nicht auf. Bei beiden Prozessen kommt es zur Kornfeinung, die beeinflusst wird von Verformungstemperatur, Druck und Verformungsgrad. Eine verbesserte Duktilität kann im Zugversuch nicht festgestellt werden, während eine gesteigerte Festigkeit durch Mikro- härtemessungen bestätigt wird. Bei genügend hoher Verformung findet man auch nach der Verformung von Einkristallen eine typische SchertexturNiAl is an intermetallic compound with a cubic B2 structure. Below the brittle-to-ductile transition temperature at about 300°C under ambient pressure the number of independent slip systems that have to be activated for a homogeneous plastic deformation is not sufficiently high according to the von Mises criterion. This is because the fracture stress is smaller than the critical yield stress for the activation of the secondary slip system. Despite this, severe plastic deformation is possible under a high pressure. It can be realized by deforming by equal channel angular pressing (ECAP) or high pressure torsion (HPT). Thereby a very high degree of deformation is reached. In this work, texture and microstructure evolution after deformation by HPT at different tem- peratures between room temperature and 500°C and at different hydrostatic pressures and degrees of deformation are analysed and compared to texture and microstructure after ECAP. After deformation by HPT, a texture typical for sheared body-centred metals is found; besides, for a deformation temperature of 100°C and higher an oblique cube component appears. It develops by dynamic recrystallization and grows with increasing deformation temperature. The shear texture also arises in the ECAP deformed samples, but no oblique cube texture is found. Both processes lead to grain refinement, which is influenced by deformation temperature, pressure, and degree of deformation. Tensile testing doesn’t show an enhanced ductility, but an improved strength is confirmed by microhardness measurements. If the degree of deformation is high enough, a shear texture can even be found after deforming single crystals
18
Al-Adsani, Ahmad Saad. "Hybrid permanent magnet machines for electric vehicles". Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/hybrid-permanent-magnet-machines-for-electric-vehicles(457bd49f-4e9c-4f9b-8436-589ab5e2d02d).html.
Abstract (sommario):
In this research study, the feasibility of using one of the Hybrid Permanent Magnet (HPM) machine topologies acting as a generator with a passive rectification stage is considered. The primary application area is in the power-train of a series hybrid electric vehicle where the concept will be considered as an alternative to brushless PM machines interfacing to the vehicle power-train via active power electronic converters. The electro-magnetic design of the two main parts in the selected HPM generator topology and their individual system behaviour at normal and rated conditions will be studied. Prediction of the transient and steady state temperature in some of the HPM machine parts will be conducted based on commercial thermal analysis software. Two HPM machine stator winding configurations; 3-phase and 9-phase, with their relevant passive rectification stages will be analysed in terms of their terminal and DC-link output power along with the quality of the generated DC output voltage. An investigation of the operational characteristic of the HPM generator when delivering a fixed power at a fixed speed into a dynamic DC voltage source typical of a hybrid electric vehicle power-train subject to urban driving regimes will be presented. The research work will be a mixture of simulation studies using electro-magnetic finite element analysis (FEA), transient machine and system analysis via SimPower, a Matlab/Simulink toolbox set, along with test validation via a representative prototype HPM generator configuration and its interface to an experimental electrical system evaluation platform.
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Di, Domenico Daniel. "HPSM: uma API em linguagem c++ para programas com laços paralelos com suporte a multi-CPUs e Multi-GPUs". Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/12171.
Abstract (sommario):
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESParallel architectures has been ubiquitous for some time now. However, the word ubiquitous can’t be applied to parallel programs, because there is a greater complexity to code them comparing to ordinary programs. This fact is aggravated when the programming also involves accelerators, like GPUs, which demand the use of tools with scpecific resources. Considering this setting, there are programming models that make easier the codification of parallel applications to explore accelerators, nevertheless, we don’t know APIs that allow implementing programs with parallel loops that can be processed simultaneously by multiple CPUs and multiple GPUs. This works presents a high-level C++ API called HPSM aiming to make easier and more efficient the codification of parallel programs intended to explore multi-CPU and multi-GPU architectures. Following this idea, the desire is to improve performance through the sum of resources. HPSM uses parallel loops and reductions implemented by three parallel back-ends, being Serial, OpenMP and StarPU. Our hypothesis estimates that scientific applications can explore heterogeneous processing in multi-CPU and multi-GPU to achieve a better performance than exploring just accelerators. Comparisons with other parallel programming interfaces demonstrated that HPSM can reduce a multi-CPU and multi-GPU code in more than 50%. The use of the new API can introduce impact to program performance, where experiments showed a variable overhead for each application, that can achieve a maximum value of 16,4%. The experimental results confirmed the hypothesis, because the N-Body, Hotspot e CFD applications achieved gains using just CPUs and just GPUs, as well as overcame the performance achieved by just accelerators (GPUs) through the combination of multi-CPU and multi-GPU.
Arquiteturas paralelas são consideradas ubíquas atualmente. No entanto, o mesmo termo não pode ser aplicado aos programas paralelos, pois existe uma complexidade maior para codificálos em relação aos programas convencionais. Este fato é agravado quando a programação envolve também aceleradores, como GPUs, que demandam o uso de ferramentas com recursos muito específicos. Neste cenário, apesar de existirem modelos de programação que facilitam a codificação de aplicações paralelas para explorar aceleradores, desconhece-se a existência de APIs que permitam a construção de programas com laços paralelos que possam ser processados simultaneamente em múltiplas CPUs e múltiplas GPUs. Este trabalho apresenta uma API C++ de alto nível, denominada HPSM, visando facilitar e tornar mais eficiente a codificação de programas paralelos voltados a explorar arquiteturas com multi-CPU e multi-GPU. Seguindo esta ideia, deseja-se ganhar desempenho através da soma dos recursos. A HPSM é baseada em laços e reduções paralelas implementadas por meio de três diferentes back-ends paralelos, sendo Serial, OpenMP e StarPU. A hipótese deste estudo é que aplicações científicas podem valer-se do processamento heterogêneo em multi-CPU e multi-GPU para alcançar um desempenho superior em relação ao uso de apenas aceleradores. Comparações com outras interfaces de programação paralela demonstraram que o uso da HPSM pode reduzir em mais de 50% o tamanho de um programa multi-CPU e multi-GPU. O uso da nova API pode trazer impacto no desempenho do programa, sendo que experimentos demonstraram que seu sobrecusto é variável de acordo com a aplicação, chegando até 16,4%. Os resultados experimentais confirmaram a hipótese, pois as aplicações N-Body, Hotspot e CFD, além de alcançarem ganhos ao utilizar somente CPUs e somente GPUs, também superaram o desempenho obtido por somente aceleradores (GPUs) através da combinação de multi-CPU e multi-GPU.
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Neves, Juliana dos Santos 1982. "Efeito da administração intermitente de hPTH(1-34) nos estágios iniciais de reparo alveolar após exodontia de molares de ratos". [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288496.
Abstract (sommario):
Orientadores: Pedro Duarte Novaes, Cristiane Ribeiro SalmonTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
Made available in DSpace on 2018-08-20T00:19:31Z (GMT). No. of bitstreams: 1 Neves_JulianadosSantos_D.pdf: 4044530 bytes, checksum: 22df8d6b0c562b9ece71cf5970d118cc (MD5) Previous issue date: 2012
Resumo: A administração intermitente do hormônio paratireóideo (PTH) promove um aumento da massa óssea, sendo atualmente utilizado no tratamento de osteoporose. Entretanto, poucos estudos têm avaliado os efeitos do PTH sobre o metabolismo do osso alveolar, e mais especificamente, no processo de reparo desta estrutura, podendo este surtir um efeito favorável na cicatrização da ferida alveolar. Considerando-se que o padrão de cicatrização da ferida do alvéolo de molares de ratos é similar ao de humanos e a sua relevância clínica, este estudo teve como objetivo analisar o efeito da administração intermitente do PTH sobre o reparo alveolar após exodontia de molares de ratos. Ratas Wistar de 200g tiveram seus primeiros molares inferiores extraídos e receberam injeções subcutâneas de 40 ?g/kg de hPTH(1-34) (grupo PTH) ou solução veículo (grupo controle) em dias intemitentes após a exodontia. Os animais foram sacrificados aos 3, 5, 7 e 11 dias após a cirurgia. Análises histomorfométricas do volume de osso recém-formado, número de osteoblastos e osteoclastos TRAP-positivos foram realizadas em cortes histológicos seriados. O Ligante do receptor ativador do fator nuclear ?? (RANKL), Sialoproteína óssea (BSP) e Osteopontina (OPN) foram localizadas no alvéolo em cicatrização por imunohistoquímica. A expressão dos genes de Colágeno 1 (Col1?1), Fosfatase alcalina (Alp), Fator de crescimento insulínico (Igf-1), Osteocalcina (Ocn), Bsp, Opn, Osteoprotegerina (Opg) e Rankl, foi analisada por qRT-PCR. A presença de osso recém-formado foi notada em alvéolos a partir de 5 dias de reparo em ambos os grupos. O volume de osso recém-formado foi significativamente maior no grupo PTH nos períodos de 5, 7 e 11 dias (p<0.05), acompanhado de um número maior de osteoblastos aos 5 dias de reparo (p<0.05). No grupo controle houve um aumento gradual na expressão de todos os genes estudados, com exceção de OPN, nos períodos após a cirurgia. De um modo geral, a expressão de Col1?1, Alp, Igf-1 e Ocn foi maior no grupo PTH nos períodos iniciais, seguido por um decréscimo significativo aos 7 dias de reparo comparado ao grupo controle. A expressão de Bsp foi similar em ambos os grupos, enquanto a expressão de Opn foi menor vi no grupo PTH aos 7 e 11 dias de reparo, com estas proteínas apresentando a mesma distribuição nas trabéculas ósseas em formação no interior do alvéolo. O número de osteoclastos TRAP-positivos foi similar em ambos os grupos em todos os períodos avaliados, assim como o padrão de marcação para RANKL. Entretanto, a razão dos genes Rankl:Opg foi maior no grupo PTH aos 11 dias de reparo, sugerindo que o PTH pode favorecer a osteoclastogênese a partir deste período. Conclui-se que o tratamento intermitente com hPTH (1-34) teve um efeito anabólico sobre o processo de reparo do osso alveolar de forma pontual aos 5 dias, estimulando o aumento no número de osteoblastos e da expressão de genes relacionados a diferenciação e produção de matriz por estas células, causando consequentemente, um aumento no volume de osso recém-formado no interior do alvéolo
Abstract: The intermittent administration of parathyroid hormone (PTH) promotes an increase in bone mass, and it is currently used to treat osteoporosis. However, few studies have evaluated the effects of PTH on the metabolism of the alveolar bone, and more specifically in the repair process of this structure, which may have a positive effect on alveolar wound healing. Considering that the pattern of the alveolar wound healing post molar extraction in rats is similar to that of the humans and its clinical relevance, this study aimed to analyze the effect of intermittent PTH administration on alveolar wound healing after extraction of rat molars. Wistar rats (200g) had their first molars extracted and received subcutaneous injections of 40 ?g/kg of hPTH (1-34) (PTH group) or vehicle solution (control group) in alternated days after the extraction. The animals were sacrificed at 3, 5, 7 and 11 days after surgery. Histomorphometric analysis of the volume of newly formed bone, number of osteoblasts and TRAP-positive osteoclasts were performed on serial histological sections. Receptor activator of nuclear factor ?? ligand (RANKL), bone sialoprotein (BSP) and osteopontin (OPN) were localized at the healing socket by immunohistochemistry. Collagen 1 (Col1?1), alkaline phosphatase (Alp), insulin growth factor (Igf-1), osteocalcin (Ocn), Bsp, Opn, osteoprotegerin (Opg) and Rankl gene expression was assessed by qRT-PCR. Newly formed bone was observed in sockets from 5 days of repair in both groups. The volume of newly formed bone was significantly higher in PTH group at 5, 7 and 11 days of repair (p <0.05). In the control group there was a gradual increase in the expression of all genes studied, except for Opn, through the periods of healing. Overall, the expression of Col1?1, Alp, Igf-1 and Ocn in the PTH group was higher at the initial periods, followed by a significant down-regulation at 7 days of repair compared to the control group. Bsp expression was similar in both groups, while Opn expression was down-regulated by PTH at 7 and 11 days of repair. Both proteins showed the same distribution on the forming trabeculae in the socket. The number of TRAP-positive osteoclasts was similar in both groups in all periods of repair, as well as the labeling pattern for RANKL. However, viii Rankl:Opg ratio was higher in the PTH group at 11 days of repair, suggesting that PTH may promote osteoclastogenesis from this period. In conclusion, the intermittent treatment with hPTH-(1-34) had an anabolic effect on the alveolar wound healing specifically at 5 days of repair, stimulating an increase on the osteoblast number and on the expression of genes related to the differentiation and production of bone matrix by these cells, thereby resulting in increased volume of newly formed bone in the healing socket
Doutorado
Histologia e Embriologia
Doutor em Biologia Buco-Dental
21
Sabapathy, K. "Factors associated with the uptake of HIV testing and treatment in the first year of the HPTN 071 (PopART) intervention". Thesis, London School of Hygiene and Tropical Medicine (University of London), 2017. http://researchonline.lshtm.ac.uk/4645535/.
Abstract (sommario):
Introduction: The HPTN 071 (PopART) trial is a community randomised trial in Zambia and South Africa, examining the impact of combination prevention, including treatment as prevention using Universal Test and Treat (UTT), on community level HIV-incidence. This PhD evaluates the factors associated with uptake of the key interventions, during the first year of the trial. Methods: Two systematic reviews were conducted on home-based HIV testing and counselling (HB-HTC), and the cascade-of-care following community-based HTC, respectively. In addition, two case-control (CC) studies were nested within PopART, to examine factors associated with the uptake of the door-to-door home-based universal testing (CC study 1), and universal treatment (CC study 2) interventions. Results: Our results suggest that HB-HTC in sub-Saharan Africa is widely accepted – uptake among those offered HB-HTC was 83% in a systematic review and meta-analysis of studies (2000-2012). The second systematic review found considerable variability in measures used to report linkage-to-care and ART initiation and in outcomes reported, even for similar time periods following HIV-detection (studies between 2006-2016). CC1 found no differences between acceptors and non-acceptors of HB-HTC by demographic and behavioural characteristics. CC2 identified that the more lifetime sexual partners participants reported, the more likely they were to achieve timely linkage and ART initiation (TLA). Negative perceptions about clinic infra-structure were associated with failure to achieve TLA. Both CC studies found that favourable views about the Community HIV-care Providers was associated with uptake of interventions, while neither stigma nor unfavourable views about clinic staff were associated with uptake. Conclusion: This PhD contributes to knowledge on the cascade-of-care and UTT. It suggests that PopART interventions are acceptable across population sub-groups, providing optimism for achieving universal coverage using the PopART model to implement UTT. If individuals with high-risk sexual behaviour embrace interventions as we observed, there is great promise for treatment as prevention.
22
Cecilia, Johansson, e Fahira Kocevic. "Vägen till ändrade levnadsvanor : -erfarenheter från personer med övervikt och fetma". Thesis, Högskolan i Halmstad, Akademin för hälsa och välfärd, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-33694.
Abstract (sommario):
Några bidragande faktorer till övervikt och fetma är levnadsvanor som innefattar inaktivitet och felaktiga kostvanor. Personer med övervikt och fetma kan få hjälp från primärvården att påverka vikten till det bättre. Syfte med studien var att undersöka vilka erfarenheter personer med övervikt och fetma har av samtal om levnadsvanor med distriktssköterskan. Studien genomfördes som integrativ litteraturstudie vilket ger djupare förståelse för ett visst fenomen inom hälso-och sjukvården. Litteraturstudiens resultat baseras på 16 vetenskapliga artiklar. I analysen framkom fyra kategorier: Betydelsen av att bli motiverad, betydelsen av egen inställning till samtal om levnadsvanor, betydelsen av distriktssköterskans kommunikativa förmåga, betydelsen av distriktssköterskans kunskap och kompetens. Distriktssköterskans kommunaktion var avgörande för hur patienten upplevde samtalet om levnadsvanor. När distriktssköterskan tillsammans med patienten satte upp mål och råden individanpassades motiverades patienten att ändra levnadsvanor. Patienternas motivation minskade när de upplevde att råden de fått var generella. Vissa patienter upplevde att distriktssköterskan inte hade tillräckligt med kunskap för att hantera övervikt och fetma. Kategorierna visar sig överensstämma med Penders hälsofrämjande arbetsmodell som förklaringsmodell för förståelse för patientens motivation till ändrade levnadsvanor.Some factors that contribute to overweight and obesity are lifestyle related and comprise a lack of physical activity and poor nutrition. Overweight and obese individuals may seek medical attention and acquire advice on how to lose their weight. The purpose of this study was to look into the experiences of the overweight and obese patients pertaining to lifestyle conversations with the district nurse. The study was conducted as an integrative literature overview, which enables a better understanding of a certain phenomenon within medical service. The results consist of sixteen scientific articles. The analysis reveals four categories: the significance of becoming motivated, the significance of one’s own attitude towards conversations about lifestyle, the significance of the district nurse’s communicative skills and the district nurse’s knowledge and competence. The communicative skills of the district nurse played a pivotal role in how the conversations about lifestyle were perceived by the patients. When the district nurse and the patient set individual goals together, the patient appeared more motivated to make a lifestyle change. On the other hand, the motivation of the patient decreased when the advice received was too generalized. Moreover, some patients believed that the district nurse was not adequately knowledgeable to deal with overweight and obesity. The categories correlate with Pender's health-promoting model as an explanation of patients' motivation in changing their lifestyles.
23
Courtin, Laurine. "Optimisation de la transformation à froid des tubes de gaine en acier austénitique 15-15TI AIM1". Thesis, Poitiers, 2015. http://www.theses.fr/2015POIT2277/document.
Abstract (sommario):
Afin de faire face aux besoins croissants en énergie, les réacteurs de 4ème génération sont envisagés mondialement. Un premier prototype de réacteur à neutrons rapides à caloporteur sodium (appelé ASTRID) est à l'étude au CEA. Le matériau de référence retenu pour le gainage combustible du premier coeur est l'acier austénitique 15-15Ti - AIM1 (Austenitic Improved Material). L’objectif de la thèse est d’étudier des voies d’optimisation de la gamme de mise en forme à froid du gainage permettant d’améliorer la résistance au gonflement. Les investigations portent principalement sur les conditions de transformation à froid et les traitements thermiques appliqués au cours de la mise en forme (notamment lors du dernier traitement d’hypertrempe). Les effets de ces paramètres sont étudiés en lien avec la microstructure (notamment l’affinement structural, l’état de précipitation, la remise en solution des éléments d’addition et l’arrangement des dislocations).La démarche adoptée se divise en trois étapes principales :- une analyse des gammes de fabrication mises en oeuvre par le passé ainsi qu’une étude des conditions d’étirage à froid et des traitements thermiques appliqués ;- une évaluation de nouveaux procédés de mise en forme tels que le laminage à pas de pèlerin et le martelage visant à valider la fabrication des tubes finis selon les spécifications requises ;- une optimisation des gammes de fabrication à froid et de la microstructure du matériau final. Les résultats de caractérisation de la microstructure et du comportement mécanique permettent d’envisager favorablement l’utilisation d’un procédé alternatif tel que le laminage à pas de pèlerin pour fabriquer les tubes de gaineIn order to face the next century energy demand growth, the worldwide development of the 4th generation of nuclear reactors is considered. The construction of a sodium-cooled fast reactor prototype (ASTRID) is currently envisaged at the CEA. The reference material selected for the fuel cladding of its first core is the 15-15Ti-AIM1 austenitic steel (Austenitic Improved Material).The goal of this PhD thesis work is to investigate the different ways of optimization for the coldworking steps undergone by the claddings during their manufacture in order to improve their swelling resistance. The main investigations are focused on the conditions of the cold-working steps and the thermal treatments applied throughout the shaping of the claddings, especially of the last solution annealing treatment. The effects of these parameters on the microstructure are investigated (structural refinement, precipitation and the additive elements dissolution and arrangement of the dislocations).This study is divided into three main steps:- an analysis of the fabrication routes applied in the past along with the study of the “coldwork” and the thermal treatments conditions;- an assessment of new shaping processes, such as the “cold-pilgering” and the hammering, in order to verify the conformity of the manufactured tubes with respect to the required specifications.- an attempt of optimization of the cold-work routes and the microstructure of the final material. The results of microstructure characterization and the mechanical behavior allow envisaging favorably the use of an alternative process such as the cold pilgering to manufacture claddings
24
Huang, Tsang-Min. "Phase Equilibria of Binary Liquid Crystal Mixtures Involving Induced Ordered Phases". University of Akron / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=akron1284381816.
25
Andrews, Ronnee Nickole. "The Applicability of 8-Hydroxypyrene-1,3,6-trisulfonic Acid to Spectroelectrochemical Sensing". University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1249999431.
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SOUZA, AUREA de. "Comportamento do AnB/KOH/HPt-B na vulcanizacao do latex de borracha natural induzida com raios gama". reponame:Repositório Institucional do IPEN, 1994. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10362.
Abstract (sommario):
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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
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Li, Ruo Ya. "Clonage d'une tyrosine-phosphatase membranaire (HPTP-béta) et étude de l'implication de la SH-PTP1 dans l'agrégation plaquettaire induite par la thrombine". Toulouse 3, 1995. http://www.theses.fr/1995TOU30150.
Abstract (sommario):
La phosphorylation des proteines sur les residus tyrosines est un evenement majeur de l'activation cellulaire. Ce mecanisme est regule par deux types d'enzymes: les proteines tyrosines kinases (ptks) et les proteines tyrosines phosphatases (ptpases). L'essentiel de nos travaux a porte sur l'etude de ces dernieres dans l'agregation plaquettaire. Dans le but de determiner si les ptpases participent au processus de reorganisation du cytosquelette lors de la stimulation des plaquettes par la thrombine, nous avons mesure les activites enzymatiques dans les differents compartiments subcellulaires de cellules au repos et activees. L'activite phosphatasique (35%) dans les cellules au repos se repartit entre le cytosol (65%) et la fraction particulaire (35%). Cette activite est tres basse dans le cytosquelette des cellules au repos et elle augmente de 8 fois dans cette fraction 2 minutes apres l'action de la thrombine. Afin d'identifier les ptpases impliquees, nous avons recherche l'hptp beta, phosphatase de type recepteur dont nous avons clone l'adnc a partir d'une banque de poumon humain. Par des techniques d'immuno-empreinte utilisant deux anticorps polyclonaux produits au laboratoire, nous avons montre qu'une proteine de 58 kda homologue de l'hptp beta transloque au niveau du cytosquelette lors de l'activation plaquettaire. Nous avons egalement mis en evidence une autre ptpase, la sh-ptp1 localisee au niveau du cytosquelette des plaquettes activees. Cette localisation, dependante de l'agregation plaquettaire mediee par l'integrine alpha iib/beta 3, est precedee d'une activation de la phosphatase (60%) par phosphorylation sur les residus serines et tyrosines. Un pretraitement des plaquettes a la toxine pertussique inhibe de 70% la phosphorylation sur les residus tyrosines indiquant ainsi la participation de proteines g trimeriques (gi) dans la voie d'activation de la sh-ptp1. La ou les tyrosines kinases impliquees restent encore inconnues et leur identification constitue un axe prioritaire de nos projets de recherche
28
Masi, Giulia. "Studio del ruolo di mutazioni missenso di CDC73 e microRNA in tumori CDC73-correlati familiari e sporadici". Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422108.
Abstract (sommario):
Mutations of the CDC73 oncosuppressor gene, encoding for parafibromin, are associated with the HPT-JT syndrome, an autosomic dominant syndrome whose clinical manifestations are mainly parathyroid tumors and, less frequently, ossifying fibromas of the jaws and various types of benign or malignant uterine and renal anomalies.
There are no data in the literature about CDC73 mutational status in ossifying jaw tumors from HPT-JT patients.
In the present study, we identified a novel CDC73 missense substitution, Ile60Asn, in the mandibular tumor of a patient from a well-characterized HPT-JT kindred with a germline frameshift mutation in the CDC73 gene. Missense mutations of the CDC73 oncosuppressor gene are very rare and often involve residues at the N-terminal of parafibromin, whose structure and function are to date unknown.
According to an in silico prediction, the Ile60Asn substitution was predicted to be pathogenetic and involved a conserved amino acid. In order to analyze in vitro the tumorigenic potential of this mutation, we performed transfection experiments in HEK293A cells to assess effects on subcellular localization, mutant protein amount, cell proliferation, apoptosis, and cyclin D1 and c-Myc expression. We demonstrated that the Ile60Asn mutant was less expressed than the wild-type protein, lacked nucleolar localization, was less able to decrease cyclin D1 expression, and increased the percentage of cells in the G2-M phases of cellular cycle. No effects were observed on c-Myc expression and on induction of spontaneous apoptosis.
In conclusion, the Ile60Asn mutation exibited dominant interfering properties and not only determined production of an inactive parafibromin. The nucleolar localization of parafibromin is likely crucial to fully elicit the antiproliferative effects of parafibromin.
These results indicate that ossifying fibromas of the jaw arising in patients with HPT-JT syndrome are not secondary effects of hyperparathyroidism, but occur for a second distinct mutational event in the CDC73 gene.
CDC73 mutations are involved not only in familial forms of primary hyperparathyroidism; inactivating CDC73 mutations are found in 77% of sporadic malignant parathyroid tumors. A high percentage of sporadic carcinomas with CDC73 genetic anomalies shows a strong loss of immunoreactivity for parafibromin. By converse, in sporadic parathroid adenomas, CDC73 seems not to have a clear pathogenetic role: alterations in this gene are very rare (0-4%) in benign tumors.
Nevertheless, in previous observations of our research group, parafibromin immunoreactivity showed great variability, with no significant difference between benign and malignant sporadic parathyroid tumors. In addition, some cases of sporadic parathyroid adenomas without CDC73 mutations with low parafibromin expression were observed. We can hypothesize the presence of mechanisms different from CDC73 mutations that might result in decrease of parafibromin expression, like down-regulation by microRNAs (miRNAs). To date, in the literature there are only two studies on miRNAs expression profile in sporadic parathyroid tumors. We performed miRNA-profiling with miRNA-microarrays on 8 sporadic parathyroid adenomas and 3 sporadic parathyroid carcinomas, in order to identify differentially expressed miRNAs. A SAM approach failed to demonstrate significantly different miRNAs in sporadic adenomas vs. carcinomas, while Gene Set Enrichment Analysis on cell pathways-associated miRNAs found an enrichment for miRNAs linked to PKC and PTEN pathway in adenomas and for miRNAs linked to SHH pathway in carcinomas.
We selected for further analysis miR-9, acting in both PKC and PTEN pathways, and predicted in silico to target CDC73. Luciferase assay and western blot in HEK293A cells showed that miR-9 is able to downregulate parafibromin expression. In addition, there was an indirect effect on cyclin D1 expression, that was upregulated in cells transfected with miR-9.
In paraffin-embedded sections of the tumor tissues employed for miRNA-microarray analysis, there were no correlations between miR-9 level in real-time RT PCR and parafibromin or cyclin D1 immunoreactivity.
In conclusion, in sporadic parathyroid tumors we failed to demonstrate miRNAs differentially expressed between benign and malignant neoplasms. MiR-9 targets CDC73 in vitro, but in vivo it seems not to account for differences in parafibromin and cyclin D1 immunoreactivityMutazioni del gene oncosoppressore CDC73, codificante per parafibromina, sono associate alla sindrome da iperparatiroidismo-tumori mandibolari (HPT-JT): tale sindrome, a trasmissione autosomica dominante, è caratterizzata principalmente dall’insorgenza di tumori paratiroidei e, meno frequentemente, di fibromi ossificanti mandibolari e di vari tipi di anomalie uterine e renali, sia benigne che maligne. In letteratura non esistono dati riguardo allo stato mutazionale di CDC73 nei fibromi ossificanti mandibolari dei pazienti HPT-JT. Nel presente studio, è stata identificata una nuova mutazione somatica missenso di CDC73, Ile60Asn, nel tumore mandibolare di una paziente di una famiglia HPT-JT portatrice di una mutazione germinale frameshift di CDC73. Le mutazioni missenso di CDC73 sono molto rare, e spesso interessano residui nella porzione N-terminale di parafibromina, la cui funzione non è ancora nota. Secondo una predizione in silico, la sostituzione Ile60Asn è verosimilmente patogenetica, e altera un amminoacido altamente conservato. Per studiare in vitro il potenziale tumorigenico della mutazione, sono stati effettuati esperimenti nella linea cellulare HEK293A per analizzare possibili effetti su localizzazione subcellulare e livello di espressione della proteina mutata, proliferazione cellulare, apoptosi ed espressione di ciclina D1 e c-Myc. E’stato osservato che il mutante Ile60Asn era meno espresso della sua controparte wild-type, era privo di localizzazione nucleolare e mostrava ridotta capacità di inibizione dell’espressione di ciclina D1; inoltre, la frazione cellulare nelle fasi G2-M risultava aumentata nelle cellule trasfettate con parafibromina mutata. Non sono stati osservati effetti sull’espresione di c-Myc e sull’induzione di apoptosi. In conclusione, la mutazione Ile60Asn sembrava agire secondo un meccanismo di dominanza negativa, e non dare origina solamente ad una forma inattiva di parafibromina. La localizzazione nucleolare di parafibromina è verosimilmente cruciale per perrmettere alla proteina di esercitare le sue funzioni antiproliferative. Questi risultati indicano che i fibromi ossificanti mandibolari che insorgono in pazienti con HPT-JT non rappresentano effetti secondari dell’iperparatiroidismo, ma si presentano in seguito ad un secondo evento mutazionale a carico di CDC73. Le mutazioni di CDC73 non sono responsabili solamente dell’insorgenza di forme familiari di iperparatiroidismo primitivo: mutazioni inattivanti di questo gene, infatti, vengono identificate nel 77% circa dei tumori paratiroidei sporadici maligni. Un’elevata percentuale di carcinomi sporadici con anomalie a carico di CDC73 mostra una forte perdita di immunoreattività per parafibromina. Al contrario, negli adenomi paratiroidei sporadici, CDC73 non sembra avere un ruolo patogenetico di primo piano, dato che risulta mutato molto raramente (0-4%) nei tumori benigni. Tuttavia, secondo nostre precedenti esperienze, l’immunoreattività per parafibromina mostra elevata variabilità, senza differenze significative tra tumori paratiroidei sporadici benigni e maligni. Inoltre, sono stati osservati alcuni casi di adenoma paratiroideo sporadico privi di mutazioni di CDC73, ma con basso livello di espressione di parafibromina. E’quindi possibile ipotizzare l’esistenza di meccanismi, differenti dalla mutazione di CDC73, che possano causare una diminuzione dell’espressione di parafibromina: tra questi, una down-regolazione ad opera di microRNA (miRNA). Attualmente, in letteratura sono presenti solamente due studi sul profilo di espressione di miRNA nei tumori paratiroidei sporadici. Nel presente studio, è stato attuato un approccio di profiling con miRNA-microarrays in 8 adenomi e 3 carcinomi paratiroidei sporadici, per identificare miRNA differenzialmente espressi tra le due condizioni. L’analisi SAM non ha evidenziato miRNA significativamente differenti tra tumori benigni e maligni, mentre la Gene Set Enrichment Analysis su miRNA associati a determinate pathways cellulari ha identificato un arricchimento nei miRNA collegati alle pathways di PKC e PTEN negli adenomi, ed alla pathway di SHH nei carcinomi. E’stato scelto per ulteriori approfondimenti sperimentali miR-9, collegato ad entrambe le vie PKC e PTEN, che ha fra i suoi target predetti in silico CDC73. Il saggio dell’attività luciferasica e il western blot in cellule HEK293A hanno dimostrato che miR-9 era in grado di diminuire l’espressione di parafibromina. Inoltre, era presente un effetto indiretto sull’espressione di ciclina D1, più espressa in cellule trasfettate con miR-9. In sezioni incluse in paraffina dei tessuti tumorali impiegati per l’analisi con mirNA-microarrays, non sono state osservate correlazioni tra il livello di miR-9 e l’immunoreattività per parafibromina e ciclina D1. In conclusione, nei tumori paratiroidei sporadici non è stata evidenziata la presenza di miRNA differenzialmente espressi tra adenomi e carcinomi. MiR-9 ha CDC73 come target in vitro, ma in vivo non sembra essere responsabile delle differnze di immunoreattività per parafibromina e ciclina D1
29
Bejranonda, Somskaow. "An assessment of the soil erosion impacts on lakeside property values in Ohio: a hedonic pricing method (HPM) application". Connect to resource, 1996. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1244216361.
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Costa, Rosimeire Filgueira. "Contribui??o da poliacrilamida parcialmente hidrolisada em associa??o com a bentonita em fluidos de perfura??o aquosos". Universidade Federal do Rio Grande do Norte, 2015. http://repositorio.ufrn.br/handle/123456789/20287.
Abstract (sommario):
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Neste trabalho, foi investigado o efeito da adi??o de poliacrilamida parcialmente hidrolisada (HPAM) e bentonita nas propriedades f?sico-qu?micas de fluidos de perfura??o aquosos. Duas formula??es foram avaliadas: a formula??o F1, que foi utilizada como refer?ncia, contendo carboximetilcelulose (CMC), ?xido de magn?sio (MgO), calcita (carbonato de c?lcio ? CaCO3 ), goma xantana, cloreto de s?dio (NaCl) e triazina (bactericida); e a formula??o F2, contendo HPAM em substitui??o a CMC e bentonita em substitui??o ? calcita. Os fluidos preparados foram caracterizados quanto ?s propriedades reol?gicas, a lubricidade e o volume de filtrado. A calcita foi caracterizada por granulometria e an?lise termogravim?trica (TGA). A formula??o F2 apresentou controle de filtra??o ? temperatura de 93 ?C 34 mL, enquanto a F1 apresentou filtra??o total. O coeficiente de lubricidade da formula??o F2 foi 0, 1623 e o da F1 0, 2542, acarretando uma redu??o de torque de 25% para F1 e de 52% para F2, comparado ? ?gua. Na temperatura de 49 ?C e taxa de cisalhamento 1022 s ?1 , as viscosidades aparentes foram 25, 5 e 48 cP para as formula??es F1 e F2, respectivamente, evidenciando maior resist?ncia t?rmica para F2. Com a comprova??o da maior estabilidade t?rmica de F2, um planejamento fatorial foi realizado, a fim de determinar as concentra??es de HPAM e de bentonita de melhor desempenho nos fluidos. O planejamento estat?stico gerou superf?cies de resposta indicando as melhores concentra??es de HPAM (4, 3 g/L) e de bentonita (28, 5 g/L) para se alcan?ar propriedades melhoradas dos fluidos (viscosidade aparente, viscosidade pl?stica, limite de escoamento e volume de filtrado) com 95% de confian?a, assim como as correla??es entre esses fatores (concentra??es de HPAM e bentonita). Os testes de envelhecimento t?rmico indicaram que as formula??es contendo HPAM e bentonita podem ser utilizadas ? temperatura m?xima de 150 ?C. A an?lise do reboco formado ap?s filtra??o dos fluidos por Difra??o de Raios X indicou intera??es espec?ficas entre a HPAM e a bentonita, justificando a maior estabilidade t?rmica do fluido F2 comparado ao F1, que suporta temperatura m?xima de 93 ?C.
In this study, we investigated the effect of addition of partially hydrolyzed polyacrylamide (HPAM) and bentonite in the physicochemical properties of acquous drilling fluids. Two formulations were evaluated: F1 formulation, which was used as reference, containing carboxymethylcellulose (CMC), magnesium oxide (MgO), calcite (calcium carbonate - CaCO3 ), xanthan gum, sodium chloride (NaCl) and triazine (bactericidal); and F2, containig HPAM steady of CMC and bentonite in substituition of calcite. The prepared fluids were characterized by rheological properties, lubricity and fluid loss. Calcite was characterized by granulometry and thermal gravimetric analysis (TGA). The formulation F2 presented filtration control at 93?C 34 mL while F1 had total filtration. The lubricity coefficient was 0.1623 for F2 and 0.2542 for F1, causing reduction in torque of 25% for F1 and 52 % for F2, compared to water. In the temperature of 49 ?C and shear rate of 1022 s ?1 , the apparent viscosities were 25, 5 and 48 cP for F1 and F2 formulation, respectively, showing greater thermal resistance to F2. With the confirmation of higher thermal stability of F2, factorial design was conducted in order to determine the HPAM and of bentonite concentrations that resulted in the better performance of the fluids. The statistical design response surfaces indicated the best concentrations of HPAM (4.3g/L) and bentonite (28.5 g/L) to achieve improved properties of the fluids (apparent viscosity, plastic viscosity, yield point and fluid loss) with 95% confidence, as well as the correlations between these factors (HPAM and bentonite concentrations). The thermal aging tests indicated that the formulations containing HPAM and bentonite may be used to the maximum temperature until 150 ?C. The analyze of the filter cake formed after filtration of fluids by X-ray diffraction showed specific interactions between the bentonite and HPAM, explaining the greater thermal stability of F2 compared to the fluid F1, that supports maximum temperature of 93 ?C.
31
Nanni, Jacopo. "High performance, low cost and low consumption Radio over fiber Systems for diversified communications applications". Thesis, Paris Est, 2018. http://www.theses.fr/2018PESC1162/document.
Abstract (sommario):
Cette thèse vise à analyser en détails la possibilité d'améliorer les futurs systèmes Radio-sur-Fibre (RoF) dans différents scénarios de télécommunication, tels que les réseaux cellulaires actuels et de la prochaine génération, ainsi que dans d'autres applications telles que la radioastronomie. Le système RoF étudié est donc composé d’un laser à cavité verticale (VCSEL) fonctionnant à 850 nm, d'une fibre standard monomode (SSMF) et d'un phototransistor à hétérojonction SiGe (HPT), adoptant la technique appelée détection directe par modulation d'intensité qui est aujourd'hui l'architecture à moindre coût et la plus simple pour RoF. Cette thèse décrit en détail la propagation non naturelle dans le SSMF (conçue pour fonctionner uniquement à 1310 nm et 1550 nm) à 850 nm. A travers un modèle mathématique développé, la propagation à deux modes est décrite et les principaux phénomènes impliqués sont analysés. En particulier, le modèle se concentre sur la dispersion intermodale et le bruit modal, considérés comme les deux principales contributions de performance nuisible. Le modèle mis au point permet d'identifier les principaux paramètres qui contribuent à renforcer les effets néfastes de la dispersion intermodale et du bruit modal, à la fois en fréquence et dans le temps. A partir du modèle, des techniques possibles pour améliorer les performances sont alors proposées. En fait, une technique de pré-filtrage est réalisée afin d'éviter l'excitation du mode du second ordre, permettant une propagation quasi-monomode au sein du SSMF. La technique est validée théoriquement et expérimentalement soit pour une transmission sinusoïdale à radiofréquence unique, soit pour une transmission de signal passe-bande centrée sur une bande de radiofréquence. Il est démontré expérimentalement que possibilité d'augmenter la bande passante de modulation du système RoF, tout en réduisant les fluctuations de puissance et de gain. De plus, la technique est validée dans un véritable système de transmission LTE, ce qui permet à la technologie RoF de transmettre un signal LTE 256-QAM de 20 MHz, confirmant la possibilité d'utiliser cette technologie pour réduire le coût global et la consommation du réseau. Des travaux supplémentaires ont été réalisés sur le modèle mathématique. En fait, la propagation des deux modes est exploitée en sens inverse pour caractériser le chirp du VCSEL utilisé. Enfin, le problème du couplage entre les fibres et les dispositifs optoélectroniques est discuté et étudié afin d’améliorer les performances tout en gardant un faible coût. La possibilité d'utiliser une structure collective et passive pour coupler la fibre optique avec des photodétecteurs à petite surface et VCSEL est présentée, montrant des améliorations importantes sur l'efficacité du couplage et la tolérance au désalignementThis dissertation aims to analyze the possibility of improving in terms of cost and consumption the future Radio-over-Fiber (RoF) systems in different telecommunication scenarios, such as current and next generation of cellular networks and in other applications such as Radio Astronomy. The RoF system studied is hence composed of a Vertical Cavity Surface Emitting Laser (VCSEL) operating at 850 nm, standard single mode fiber (SSMF) and SiGe Heterojunction Phototransistor (HPT), adopting the technique called Intensity Modulation{Direct Detection which is nowadays the cheapest and simplest architecture for RoF. This dissertation describes in detail the multimode propagation within the SSMF (designed to operate only at 1310 nm and 1550 nm) which is present at 850 nm. Through a developed mathematical model, the two-modes propagation is described and the main phenomena involved are analyzed. In particular, the model focus on intermodal dispersion and modal noise which are considered the two main contributions of performance detrimental. The model developed is able to identify the main parameters which contribute to enhance the detrimental effects produced by intermodal dispersion and modal noise both in frequency and time domain. Starting from the model, possible techniques to improve the performances are then proposed. In particular, a pre-filtering technique is realized in order to avoid the excitation of the second order mode, allowing a quasi-single-modepropagation within the SSMF. The technique is theoretically and experimentally validated either for single radio frequency sinusoidal transmission either for bandpass signal transmission centered in radio frequency band. In particular it is demonstrated experimentally the possibility of increasing the modulationbandwidth of the RoF system, reducing at the same time the fluctuations of power and gain. Furthermore, the technique is validated in a real LTE transmission system, making the RoF technology proposed able to transmit 256-QAM LTE signal of 20 MHz bandwidth, confirming the possibility of using this technology to decrease the overall cost and consumption of the network. Further work hasbeen done on the mathematical model. In particular the two modes propagation is exploited reversely in order to characterize the chirp parameter of the VCSEL employed. Finally, the problem of coupling between fiber and opto-electronic devices is also discussed and investigated, in order to enhance theperformances while keeping low the cost. The possibility of utilizing a collective and passive ploymerbased structure for coupling the optical fiber with small area photodetectors and VCSEL is presented, showing important improvements on coupling efficiency and tolerance to misalignment
32
Meyer, Steven. "CONFIGURING TELEMETRY SYSTEMS FOR HIGH-POWER-MICROWAVE TESTING". International Foundation for Telemetering, 1989. http://hdl.handle.net/10150/614467.
Abstract (sommario):
International Telemetering Conference Proceedings / October 30-November 02, 1989 / Town & Country Hotel & Convention Center, San Diego, CaliforniaDuring high-power microwave (HPM) testing, where the item under test is subjected to power levels up to several thousand W/cm , the RF energy present will make typical 2 telemetry RF links useless. Therefore, other means must be used to retrieve the data during the tests. One method to accomplish data retrieval is to replace the RF data link with a fiber-optic link. This is done by replacing the transmitter with a fiber-optic transmitter on the sending end and the RF receiver with a fiber-optic receiver on the receiving end. Although this sounds simple, it is not always so. Solutions for PCM and FM-FM systems are relatively straightforward, whereas PAM systems present a unique set of problems. This paper addresses possible solutions for PCM and FM-FM and three possible solutions for PAM, one being by using a PAM-to-PCM converter.
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Araujo, Viana Carlos. "Développement technologique et intégration système de VCSEL et HPT SiGe pour des applications radio-sur-fibre 60 GHz bas coût". Thesis, Paris Est, 2014. http://www.theses.fr/2014PEST1003/document.
Abstract (sommario):
Cette thèse s'inscrit dans le cadre du projet français FUI8-ORIGIN qui vise à développer les performances des réseaux domestiques en apportant des solutions sans multi-Gigabits faiblement radiatives, économes et pérennes. La solution ORIGIN est caractérisée par l'action complémentaire de deux technologies: les communications sans fil 60 GHz, avec notamment la création récente en Janvier 2013 de la nouvelle norme WiFi 60GHz, et la mise en place d'une infrastructure Radio-sur-Fibre (RoF) afin d'étendre la propagation de ses signaux radio fortement atténués par l'atmosphère et les murs, au sein de l'ensemble de la maison. Cette thèse porte sur le développement des composants et modules optoélectroniques bas couts, permettant d'assurer ces contraintes. Le travail implique de couvrir de la puce semi-conducteur au modules et jusqu'au système intégré dans le démonstrateur. Les puces sélectionnées sont caractérisées de manière précise en développant des bancs de mesures adaptées aux applications analogiques RoF. Les performances RoF ont été évaluées et comparées en termes de réponse en fréquence, de bruit et de non-linéarités. Un dimensionnement complet de l'infrastructure Radio-sur-Fibre pour le démonstrateur est ensuite mené, intégrant et dimensionnant le bilan de liaison global à partir modules et cartes réalisés et développés par les partenaires du projet. Le module transmetteur Radio-sur-Fibre (TRoF) est ainsi conçu, assemblé et testé. Les performances du module ont été mesurées et simulées à chaque étape de la procédure d'intégration. Le démonstrateur final basé sur l'architecture multipoint-à-multipoint a été réalisée à l'aide d'un nœud central optoélectronique pour la répartition du signal et d'une Green Box permettant le contrôle de l'allumage des différentes pièces, et ainsi la rationalisation du rayonnement et de la consommation du système. Une transmission bidirectionnelle en temps réel entre deux dispositifs de Wireless HD commerciaux à ~3 Gbit/s a été démontrée. Dans une dernière section de cette thèse, des directions pour améliorer les lasers à cavité émettant par la surface (VCSEL) et les phototransistors SiGe sont explorées. Des VCSEL analogiques avec une bande passante de plus de 25 GHz sont développés avec la société Philips ULM Photonics et mesurés. Notre action s'est concentrée sur les dimensions latérales de la structure, en bénéficiant des améliorations des couches verticale de la part de ULM Photonics. Outre les dimensions du VCSEL propre, ce travail a aussi visé l'amélioration des lignes d'accès pour permettre à la fois une meilleure dissipation thermique et une meilleure adaptation réactive du VCSEL à son électronique amont. Une nouvelle technologie de couplage optique collective et passive est enfin proposée. Originale et brevetée à l'occasion de ce travail, elle permet le couplage optique vertical à la fibre optique multimode et monomode de dispositifs optoélectroniques de petites tailles, inférieurs à 10µm, ainsi permettant simultanément de réduire les pertes de couplage, d'augmenter la fréquence de fonctionnement des composants couplés en réduisant leur dimensions, et de réduire le coût et le temps de réalisation du couplageWireless communication technologies have become one of the most popular and indispensable part of people's lives in the recent years, offering mobility and services never before available from mobile communication until local network communication. This work is based on the frame of the French ORIGIN project and intended to explore the Home Area Network using the most recent Wi-Fi standard at 60 GHz with the goal to present a solution for the upcoming days where MultiGbit/s wireless communication will be required. The ORIGIN solution is characterized by the complementary action of two technologies: 60 GHz Wireless communication and Radio-over-Fiber (RoF) infrastructure. The project pretends to propose a real prototype based on RoF transducers and a Multipoint-to-Multipoint architecture to cover the entire house. This thesis covers from the single optoelectronic chip devices until the system implementation and the final demonstrator. The light source and the photodetector choice were very important since it dictated the RoF transducer architecture. Our choice was on 850 nm multimode devices (GaAs VCSEL and SiGe HPT) which allow relaxed constraints on the optical packaging and, therefore, low cost solutions. In terms of performances those devices are limited in a few tens of Gigahertz of bandwidth which was the reason for the intermediate frequency (IF) architecture. This thesis work addressed the electrical and optical interconnection of the optoelectronic chip devices. It explored the integration of hybrid amplification stages and passive networks within optoelectronic receivers and emitters. The optical packaging issues were addressed through a conventional coupling technique using a ball lens first. The die device performances were evaluated and compared with a packaged module in terms of frequency response, noise and nonlinearities. Since performances are usually measured as link performances we proposed a definition of the Opto-microwave figures of merit, such as Opto-microwave gain, noise, nonlinearities and EVM. They are presented and integrated into behavioral models, allowing both the individual performances extraction and system design. The integration of the RoF module in the system is the final part of this thesis. The performances were measured and simulated at each integration step. The final demonstrator based on the multipoint-to-multipoint architecture was implemented using an optoelectronic central node for the signal repartition and the Green Box for signal controlling. Real-time bidirectional transmission between two commercial WirelessHD devices at ~3 Gbit/s was validated. In a final section directions to improve VCSEL and SiGe HPT are explored. 25 GHz analogue VCSELs are explored with a focus on their dimensions, improved access and the potential of a suited matching approach. A novel collective and passive optical coupling technology is also proposed for both VCSEL and top illuminated detectors that couple smaller and faster devices
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Hägg, Martin. "Theoretical analysis and simulation of microwave-generation from a coaxial vircator". Thesis, Uppsala universitet, Fasta tillståndets elektronik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316595.
Abstract (sommario):
High-power microwave, HPM, systems can be used as non-lethal weapons with the ability to destroy or disturb electronics, by damaging internal circuits and inducing high currents. Today microwave sources are being developed with peak powers exceeding 1 GW, one of these devices is the vircator, a narrowband source which is unique to the HPM community. In order to understand and develop microwave sources like the vircator it is necessary to have computer models, as simulations gives an invaluable understanding of the mechanisms involved during operation, saving time and development costs. This thesis presents the results from a theoretical analysis and a simulation study using a well known electromagnetic particle-in-cell code, Computer Simulation Technology Particle Studio. The results are then compared to measured data from a HPM system, the Bofors HPM Blackout. The results show that CST PS can be used to design and study the coaxial vircator with good results.
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Lindskog, Claes. "IC-påverkan av elektromagnetisk puls". Thesis, Linköping University, Department of Electrical Engineering, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15092.
Abstract (sommario):
Detta examensarbete undersöker effekter av en elektromagnetisk puls på IC-kretsar.
För att kunna utvärdera inverkan har ett testobjekt, innehållande komponenter som skall testas, konstruerats. Detta testobjekt består av batteri, en enkel komponent och last. Ett pulsaggregat och en antenn användes för att generera de elektromagnetiska pulser som testobjektet utsattes för. Resultaten visar att inverkan på de testade komponenterna är möjlig. Inverkan visade sig vara beroende av bl.a. avståndet till antennen och den tid som testobjektet utsätts för störning. Störning har också utförts vid olika polariseringar.
Ett mål var att kunna jämföra en elektromagnetisk störning via en antenn med en trådbunden störning, där pulsen genererats från samma pulsaggregat. Försöken att utföra trådbunden störning av testobjektet misslyckades då pulsen inte var tillräckligt bra.
Detta examensarbete är en del av en artikel, High Power Ultra Wide Band and Vircator Source-Victim Experiment, som presenterades vid konferensen EMC Europe 2008.
This paper studies the effects of an electromagnetic pulse on IC-circuits. A DUT (device under test) has been constructed so that the effects of the pulse can be evaluated. The DUT consists of a battery, a load and the component, which is to be tested. A high voltage power supply and an antenna were used to generate the pulses that the DUT were exposed to. The results show that the effects were dependent on, among others, the distance between the antenna and the DUT and the time during which the DUT was exposed to the pulse. The DUT has also been exposed to different polarisations of the pulse.
One of the objectives of the study was to compare the difference between a pulse from an antenna and from a wire. This was to be done with the same high voltage power supply. Attempts to use a wire, for injecting the pulse, were unsuccessful since the damped pulse was not satisfying.
This paper is a part of a paper, High Power Ultra Wide Band and Vircator Source-Victim Experiment, that was presented at the conference EMC Europe 2008.
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Kilburn-Watt, Elisabeth. "Altered Thyroid Hormone Regulation and Behavioural Change in a Sub-population of Rats following Injury". Thesis, The University of Sydney, 2012. http://hdl.handle.net/2123/9098.
Abstract (sommario):
Overview Of This Thesis. This thesis documents an investigation of thyroid hormones and the regulation of thyroid hormones in an animal model of neuropathic pain. The technique used in this model, Chronic Constriction Injury (CCI), produces an injury that creates an inescapable mechanical and inflammatory stress for the rat. Various forms of stress, and in particular unavoidable stress, have been shown to alter thyroid hormones in both rats and humans. This rat model has been developed to more closely resemble the neuropathic pain state in humans where a proportion of patients develop a syndrome of social and behavioural changes, which has been termed ‘disability’. As well as demonstrable sensory dysfunction, as a result of the nerve injury, a sub-population of the rats exhibit altered patterns of complex social behaviours. The results of three experiments are presented. In each case a cohort of rats was subjected to the same procedure – Chronic Constriction Injury – and changes in social behaviour measured using a Resident-Intruder test. Rats were assigned to one of three groups based on the results of the behavioural test: No Disability (ND), Transient Disability (TD) or Persistent Disability (PD). In experiment 1, documented in Chapter 4, peripheral thyroid and corticosteroid hormones were measured pre and post-CCI together with Thyroid Stimulating Hormone (TSH) levels. Results for the three different behavioural groups were compared. In experiment 2, documented in Chapter 5, RNA was extracted from the hypothalamuses of rats sacrificed six days post CCI. Relative gene expression was determined for a number of factors involved in thyroid hormone and corticosteroid regulation. In experiment 3, documented in Chapter 6, at the end of the experimental period, seven days post-CCI, the rats were perfused to remove blood and the brains preserved in paraformaldehyde. The hypothalamuses were examined using immunohistochemical techniques for evidence of differing protein expression for molecules involved in thyroid hormone regulation. Summary of Findings. Behavioural Testing (Chapter 3): The results of behavioural testing for the experimental groups of animals used in this study conform to those previously found using this model (Monassi et al., 2003). Based on previously derived criteria 70% were classified as ‘No Disability’ (ND); 10% of the rats and were classified as ‘Transient Disability’ (TD) and 20% of rats were classified as ‘Permanent Disability’ (PD) animals. Rats classified as PD have significantly decreased levels of Dominance behaviour on days 1-3 and 4-6 post-CCI when compared to ND rats whereas TD rats have decreased Dominance behaviour on days 1-3 only. Pre-CCI behaviour is not predictive of post-CCI behavioural change. Peripheral Thyroid Hormones (Chapter 4): When compared to pre-injury levels, the mean total thyroxine (TT4), total triiodothyronine (TT3) and free thyroxine (fT4) levels were significantly decreased in the PD rats whereas the post-injury levels of these hormones did not change in the ND and TD rats. There was no difference between groups in mean free triiodothyronine (fT3) and thyroid stimulating hormone (TSH) levels pre and post-injury. The pattern of secretion of hormones differed in the ND and PD rats over the six days post-injury. In the ND rats, there was a surge in TSH post-injury and thyroid hormone levels were maintained at pre-injury levels. However, in the PD group, the TSH response was delayed, blunted and inadequate as thyroid hormone levels decreased. There was a significant correlation between decreased Dominance behaviour and both TT4 and fT4 but no correlation with TT3 or fT3. Peripheral Corticosteroids (Chapter 4): There was an increase in corticosterone in all animals post-CCI. The Transient Disability rats showed the greatest increase in corticosteroid and this was significantly different to the other two groups of rats. There was no difference in post-CCI corticosterone levels between the PD and ND rats. Hypothalamo-pituitary-thyroid (HPT Axis) regulation (Chapters 5 & 6): RT-qPCR measurement of relative mRNA expression in the hypothalamus showed that there was no difference between No Disability, Transient Disability and two groups of control rats (Behavioural Controls (BC) and naïve group caged controls) for Thyrotrophin Releasing Hormone (TRH), Thyroid Hormone Receptor β (TR β), Deiodinase 2 (Dio2) and Deiodinase 3 (Dio3). Compared to the BC rats, the Permanent Disability rats had significantly decreased relative expression of TRH and Deiodinase 2 and significantly increased expression of Deiodinase 3 mRNA. Immunohistochemical techniques used to label TRH, TR β, Deiodinase2 and Deiodinase 3 protein distribution in the Paraventricular Nucleus (PVN) of the hypothalamus showed significantly fewer immunoreactive profiles for Deiodinase 3 and TRβ in the group with changed behaviour (PD group) compared to the Behavioural Control rats. These differences were shown to be specific for the sections of the PVN where the hypophysiotrophic TRH secreting neurons are known to be primarily located. Hypothalamo-pituitary-adrenal (HPA axis) regulation (Chapter 5): RT-qPCR measurement of relative mRNA expression in the hypothalamus showed that there was no difference between ND, TD, PD and Behavioural Controls rats for Corticotrophin Releasing Hormone (CRH), Glucocorticoid Receptor (GR) and Vasopressin. Compared to the Behavioural Controls, group caged Control animals had significantly increased relative expression of CRH and Vasopressin mRNA.
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Rabello, Guilherme Picanço. "Processamento remoto em solução para interação com ambientes arquitetônicos 3D através de tablets". Universidade Federal de São Carlos, 2016. https://repositorio.ufscar.br/handle/ufscar/7840.
Abstract (sommario):
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
The evolution of Computer Graphics, supported by the computational development, enables increasingly advanced visual creations and promotes benefits to various areas such as: Art, architecture, Product Design, Visual Design, Games, Movies, Engineering, GIS and Medicine. However, the processing power needed for applications that require a high degree of realism, restricts the use of these applications to a small portion of the entire range of the computing devices in use by the population. Recently, the evolution of mobile network technologies brought a possible solution to the inability of most mobile devices in dealing with interactive applications and a high degree of realism. The solution is based on the remote processing of applications on servers with high processing capacity, and delivery of the images produced for mobile devices made by its conversion into video and streaming broadcasts. This master dissertation explores a remote processing solution for interacting with architectural environments through tablets. Emphasis was placed in: keeping high degree of realism, difficult to achieve due to the processing requirements in real-time interactive applications; the adaptation and combination of tools available in the market; and in mitigating latency through different ways of user interaction. The evaluation of the results was carried out in training sessions, interaction and interviews with volunteers.
A evolução da Computação Gráfica apoiada no desenvolvimento computacional possibilita criações visuais cada vez mais avançadas promovendo benefícios a diversas áreas como: Artes, Arquitetura, Design de produto, Design visual, Jogos, Cinema, Engenharia, Geoprocessamento e Medicina. Porém, a capacidade de processamento exigida por aplicações que requerem elevado grau de realismo restringe o uso dessas aplicações a uma parcela pequena de toda a gama de dispositivos computacionais instalados e de uso da população. Recentemente, a evolução das tecnologias de rede móvel trouxe uma possível solução à incapacidade da maioria dos dispositivos móveis em lidar com aplicações interativas e de elevado grau de realismo. A solução baseia-se no processamento remoto das aplicações, em servidores com elevada capacidade de processamento, e na entrega das imagens produzidas para os dispositivos móveis feita através de sua conversão em vídeo e transmissão por streaming. Este trabalho explora uma solução de processamento remoto para interação com ambientes arquitetônicos através de tablets. Deu-se ênfase às questões de manutenção de elevado grau de realismo, dificultada pelas exigências de processamento em tempo real de aplicações interativas, à adaptação e combinação de ferramental disponível no mercado e à mitigação da latência através de recursos de interface com usuário. A avaliação dos resultados foi realizada em sessões de treinamento, interação e entrevistas com usuários voluntários.
38
Chiurazzi, Sara. "Valutazione dell'ormone TSH in Tursiops truncatus". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/10029/.
Abstract (sommario):
Questa tesi si focalizza sullo studio del funzionamento dell'asse HPT in esemplari di Tursiops truncatus, mantenuti in ambiente controllato. Sono state analizzate le concentrazioni sieriche di TSH, T3 e T4 su 8 individui, 4 maschi e 4 femmine, lungo un periodo di tempo tra febbraio 2015 e febbraio 2016, tramite prelievo di sangue in concomitanza con i controlli veterinari.
Essendo il TSH un ormone specie-specifico e vista l'attuale insesistenza di sistemi per la sua rilevazione in cetacei, si è voluto valutare anche se l'utilizzo di un sistema canino con anticorpi policlonali, fosse efficace per la sua analisi in cetacei. L'analisi è stata condotta tramite il kit "Thyroid Stimulating Hormone (TSH) Canine ELISA" (DRG), da cui è stata ottenuta ottima riproducibilità ed affidabilità. L'analisi degli ormoni tiroidei T3 e T4 è stata condotta tramite i kit CLIA.
A seguito dell’analisi con sistema ELISA per TSH canino, tutti i campioni di tursiope hanno presentato concentrazioni superiori al limite di rilevabilità della metodica, pari a 0.01 ng/ml, e tutti rispecchiano e sottolineano la loro attività biologica. Il meccanismo di feeback positivo/negativo è evidenziato dall'analisi statistica: infatti, esiste una correlazione positiva tra T3 e TSH e tra T3 e T4. Per quanto riguarda i valori di T3 e T4 riscontrati, le medie ottenute indicano per il T3 valori di 1,117 ± 0,337 ng/ml e per il T4 10,806 ± 16,933 μg/dl, i quali rientrano nel range indicato dagli studi di Fair et al. (2011) e St. Aubin et al (1996). Le analisi statistiche hanno poi mostrato differenze nelle concentrazioni sieriche di tali ormoni tra maschi adulti, femmine adulte, maschio giovane e femmina giovane. Esse sono però significative solo nel caso del T3 (p= 0,006203), mentre per quanto riguarda TSH e T4, esse non risultano significative (rispettivamente p= 0,951254 e p= 0,131574).
39
Gies, Cheryl E. "Evaluating Effectiveness of an Inpatient Nurse-directed Smoking Cessation Program in a Small Community Hospital". University of Toledo Health Science Campus / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=mco1115124358.
40
Brandsch, Thomas [Verfasser], Ewa [Akademischer Betreuer] Stürmer, Franz-Josef [Akademischer Betreuer] Kramer e Patricia [Akademischer Betreuer] Virsik-köpp. "Einfluss der intermittierenden PTH-Applikation (hPTH 1-34) auf die Frakturheilung des metaphysären Knochens der orchiektomierten Ratte / Thomas Brandsch. Gutachter: Ewa Stürmer ; Franz-Josef Kramer ; Patricia Virsik-Köpp. Betreuer: Ewa Stürmer". Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1044046309/34.
41
Chen, Cai. "Textures et microstructures dans l'aluminium, le cuivre et le magnésium après hyperdéformation". Thesis, Université de Lorraine, 2016. http://www.theses.fr/2016LORR0061.
Abstract (sommario):
L'hyperdéformation est une technique efficace pour transformer la microstructure des métaux en une structure de grain de taille inférieure au micron ou même en nanostructure (<100 nm). Cette très petite taille de grain confère d'excellentes propriétés mécaniques au matériau. Dans ce travail de thèse, deux techniques d'hyperdéformation récemment développées, appelées High Pressure Tube Twisting (HPTT) and Cyclic Expansion and Extrusion (CEE) ont été appliquées à température ambiante sur différents matériaux métalliques. La fragmentation de la microstructure ainsi que le développement de la texture cristallographique ont été analysés en détails par la diffraction d'électrons rétrodiffusés (EBSD), par microscopie électronique en transmission (TEM), par transmission Kikuchi diffraction (TKD) ainsi que par diffraction des rayons X (XRD). Le gradient de déformation de cisaillement dans l'épaisseur des tubes d'aluminium déformés par HPTT a été déterminé par une méthode de mesure locale du cisaillement. Ce gradient de cisaillement induit une hétérogénéité aussi bien de microstructure que de texture dans les échantillons d'aluminium et de magnésium purs ainsi que dans l'alliage Al-4%Mg en solution solide. La micro-dureté et la taille de grain dans différentes zones ont été mesurées et analysées en fonction du taux cisaillement local. Les tailles de grain limites atteintes de façon stationnaire pour ces différents matériaux produit par HPTT sont respectivement de 700 nm, 900 nm et 100 nm. L'évolution de texture du magnésium pur après HPTT jusqu'à un cisaillement de 16 a été simulée par cisaillement simple par le model auto-cohérent (VPSC), le résultat de simulation a montré de bons accords avec les mesures de texture obtenues par XRD. Sur la base des mesures de distribution de désorientation dans l'aluminium déformé par HPTT, une nouvelle technique de détermination du taux de cisaillement local dans les procédés d'hyper déformation a été proposée. Cette nouvelle technique a été appliquée sur deux échantillons d'aluminium produit par twist extrusion (TE) et par torsion à extrémités libres. Les échantillons d'aluminium et de cuivre ont été déformés intensément par CEE. Les évolutions de texture et de microstructures ont été mesurées par EBSD, montrant un gradient du centre à la périphérie des échantillons cylindriques. L'évolution de texture dans le cuivre déformé par CEE a été simulée par le modèle VPSC en utilisant un modèle de ligne de courant pour décrire la déformation dans le procédé. Les résultats de simulation confirment les caractéristiques de la texture expérimentale observées après CEE. Le comportement en traction du cuivre pré-déformé par grande déformation en torsion a ensuite été testé. En dépit du gradient de cisaillement existant dans la barre, une technique a été proposée pour obtenir la courbe contrainte-déformation pour ce type de matériauSevere plastic deformation (SPD) is an efficient technique to transform the microstructure of bulk metals into ultra fine grained structure with grain sizes less than 1 µm or even into nanostructure with nano-grains of less than 100 nm in diameter. The very small grain size attributes excellent mechanical properties to the material. In present thesis work, two recently developed SPD techniques, namely, High Pressure Tube Twisting (HPTT) and Cyclic Expansion and Extrusion (CEE) were performed on different metallic materials at room temperature. Details of fragmentation of microstructure and metallographic texture evolution were investigated by electron backscattered diffraction (EBSD), transmission electron microscopy (TEM), transmission kikuchi diffraction (TKD) and X-ray diffraction (XRD). Shear strain gradient across the thickness of the HPTT deformed Al tube sample was found by a local shear measurement method. This shear strain gradient induced the inhomogeneity of microstructure and texture in HPTT deformed pure Al, solid solution alloy Al-4%Mg and pure Mg. The microhardness and average grain size in different zones as a function of shear strain were measured. The limiting steady grain sizes in the steady state for these different materials produced by HPTT were 700 nm, 100 nm and 900 nm, respectively. The texture evolution of pure Mg in HPTT up to a shear strain of 16 was simulated in simple shear using the self-consistent (VPSC) polycrystal model and showed good agreements with the experimental results measured by XRD. Based on the measured disorientation distribution function in HPTT deformed Al, a new technique for the magnitude of local shear strain in SPD was proposed. This new technique was applied to a protrusion produced in twist extrusion (TE) and to an Al sample deformed in free-end torsion. Cu and pure Al samples were intensively deformed by the CEE SPD technique. The microstructure and texture evolutions were measured by EBSD, showing a gradient from the center-zone to the edge part of the rod sample. The texture evolution of CEE deformed Cu was simulated by the VPSC polycrystal model using a flow line function. The simulation results confirmed the experimental texture features observed in the CEE process. The tensile testing behavior of large strain torsion pre-processed Cu was examined. In spite of the shear strain gradient existing in the bar, a technique was proposed to obtain the tensile stress-strain curve of such gradient material
42
Diniz, Sandra Maria da Fonseca. "IMPLICAÇÕES DO DIABETES MELLITUS NA QUALIDADE DE VIDA DE INDIVÍDUOS, PARTICIPANTES DO PROGRAMA DE SAÚDE PARA O DIABÉTICO TIPO 2 DO HOSPITAL DO POLICIAL MILITAR (PSPD - HPM)". Pontifícia Universidade Católica de Goiás, 2009. http://localhost:8080/tede/handle/tede/3110.
Abstract (sommario):
Made available in DSpace on 2016-08-10T10:55:46Z (GMT). No. of bitstreams: 1
SANDRA MARIA DA FONSECA DINIZ.pdf: 904945 bytes, checksum: d43fe1e9a50dffc1c64786ab54cc2ad4 (MD5)
Previous issue date: 2009-06-23It is about a study intended to evaluate the quality of life of diabetic militaries and his dependants (wives), to identify and associate the main risk factors that interfere on quality of life and make associations between quality of life and the main risk factors in diabetes mellitus 2 (DM2) patients through statistical significance and data mining. The study population was made out of 70 militaries and his wives, all patients with DM2 subscribed to the program entitled Attention, Prevention, Control and Treatment of DM2 of Military Police Hospital in Goiânia, GO, during the following period: from August to November 2008. Two closed questionnaires were applied, the first one referring to social-demographic variables, life style, clinical history, anthropometrical data, and the second one through a specific instrument of World Health Organization (WHO) to evaluate quality of life entitled WHOQOL bref. The most relevant variables and abrangência were: unbalanced diet with 78,6%, altered sugar rate with 91,5%, arterial hypertension with 54,2%, hypertension in the family with 71,4%. The complications referring to DM2 were foot injuries (25,7%), blindness (20,0%) and nephropathy (11,4%). The answers from survey individuals concerning the WHOQOL questionnaire bref detected that: 42 individuals (60,0%) considered their quality of life as good. However, 36 (51,4%) reported that they have negative feelings, sometimes. In relation to WHOQOL-bref domains, the ones of major prevalence were the social one followed by the environmental one. To execute the data mining method (Data Mininig, DM) it was utilized a tool known as Weka which allowed associations between the quality of life variables, risk factors and negative feelings. For the associations, attributes between themselves were strongly related, thus generating two associations. The first one - between quality of life and complications - and the second one - between quality of life, complications and negative feelings. Results demonstrated that the associations between quality of life, negative feelings and complications of DM have individual significance when related to the disease.
Trata-se de um estudo com objetivo de avaliar a qualidade de vida de militares diabéticos e seus dependentes (esposas), identificar e associar os principais fatores de risco que interferem na qualidade de vida, e realizar associações entre a qualidade de vida e os principais fatores de risco, em portadores de diabetes mellitus2 (DM2), através de técnicas estatísticas e da mineração de dados. A população de estudo foi constituída de 70 militares e suas esposas, todos portadores de DM2 inscritos no programa de atenção, prevenção, controle e tratamento de DM 2, do Hospital do Policial Militar em Goiânia, GO, no período de agosto a novembro de 2008. Foram aplicados dois questionários fechados, sendo o primeiro referente às variáveis sociodemográficas, estilo de vida, história clínica, dados antropométricos, e o segundo através de instrumento específico da Organização Mundial de Saúde (OMS), para avaliação da qualidade de vida, denominado WHOQUOL bref. As variáveis de maior relevância e abrangência foram: dieta não equilibrada com 78,6%, taxa de açúcar alterado com 91,5%, hipertensão arterial com 54,2%, hipertensão na família com 71,4%. As complicações referentes ao DM 2 encontradas foram a lesão em pé (25,7%) , a cegueira (20,0%) e a nefropatia (11,4%). As respostas dos sujeitos da pesquisa relativas ao questionário WHOQUOL bref detectaram que: 42 indivíduos (60,0%) consideram a sua qualidade de como boa. Entretanto, 36 (51,4%) relataram ter sentimentos negativos algumas vezes. Em relação aos domínios do WHOQOL-bref, os de maiores prevalência foram o social seguido do ambiental. Para a execução do método data mining (Mineração de Dados, MD) foi utilizada uma ferramenta conhecida como Weka que permitiu associações entre as variáveis qualidades de vida, fatores de risco e sentimentos negativos. Para as associações foram relacionados fortemente atributos entre si que geraram duas associações. A primeira entre qualidade de vida e complicações e a segunda entre qualidade de vida, complicações e sentimentos negativos. Os resultados mostram que as associações entre a qualidade de vida, os sentimentos negativos e as complicações do DM têm significado individual quando relacionados com a doença.
43
Girard, Maxime. "Recherche de vulnérabilités des étages de réception aux agressions électromagnétiques de forte puissance : cas d’un LNA AsGa". Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0296/document.
Abstract (sommario):
Ce manuscrit présente une étude de la susceptibilité d’un amplificateur faible bruit (LNA)AsGa aux agressions électromagnétiques de forte puissance. La notion d’agressionélectromagnétique de forte puissance définit, du point de vue de la CEM, un environnementélectromagnétique particulier où les niveaux de champ électromagnétique sont tels qu’ilspeuvent engendrer une dégradation physique des composants électroniques du systèmevictime. Ces champs peuvent être générés par des systèmes particuliers appelés AED EM(arme à énergie dirigée électromagnétique).Cette étude s’intéresse ainsi non seulement à l’explication des effets physiques observés surles composants cibles, mais également à l’influence des paramètres de la sourceélectromagnétique sur la susceptibilité du composant.Cette thèse a été encadrée par les équipes du laboratoire IMS de l’université de Bordeauxd’une part, et du CEA Gramat d’autre partIn this PhD thesis dissertation, a study of a GaAs low-noise amplifier (LNA) susceptibility tohigh power electromagnetic interference is presented.The term high power electromagnetic interference refers to a particular electromagneticenvironment in which E-field and H-field levels are high enough to cause physical damage tothe victim’s system electronic components.Such high level fields can be generated by dedicated systems, called electromagneticdirected energy weapons (DEW).The study presented in this document focuses not only on explaining failure mechanismstriggered by such interference, but also shows discussion on electromagnetic sourcesparameters trimming influence on component’s susceptibility
44
Can, Barboros. "Change Process Of Integrating Capability Maturity Model Integration (cmmi) Into A Technology Company: A Case Study". Phd thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612174/index.pdf.
Abstract (sommario):
The purpose of this study is to investigate the phases of change process of integrating a quality development model into an information technology company in Turkey. While the transformation phases were being examined by a qualitative study, the factors that affect the change process also were investigated.
This study explores the process of traveling through the way to CMMI (Capability Maturity Model Integration) level 3 certification by a company that gives information technologies service to banking sector. Since circulation of staff prevents us from obtaining what an exact number of workers, the company has about 450 employees. At the beginning, the company had no quality standards and most of the work processes were not documented, even documented processes were not consistent. After the
commencement of the quality development project, work flows of processes were defined and documented. The company changed its organization according to the new process improvement model, called CMMI.
In this case study, interviews performed with ten experts from inside of the company and three experts from outside of the company, observation diaries and assets of the company were data sources. Participant observation, questionnaire and document analysis were used as data gathering methods. Collected data were interpreted by descriptive analysis. As a result of the research, while resistance to change came out naturally, it is determined that transformation has four stages such as: &ldquomotivation and adoption&rdquo
, &ldquo
adaptation&rdquo
, &ldquo
acceptance and implementation&rdquo
and finally &ldquo
use and improvement&rdquo
.
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Bertheau, Lucie. "Caractérisation d'un phosphorelais multiple de type histidine-aspartate dans la transduction du signal de la contrainte osmotique chez le peuplier : mécanismes de régulation du fonctionnement d'un régulateur de réponse de type-B à l'échelle moléculaire". Thesis, Orléans, 2013. http://www.theses.fr/2013ORLE2076/document.
Abstract (sommario):
Les relais de phosphorylation de type histidine/aspartate constituent des voies de signalisation impliquées dans la perception et la transduction des signaux jusqu’à la mise en place de réponses spécifiques. Ils mettent en jeu un récepteur ou Histidine aspartate Kinase (HK), des protéines navettes en charge de la transmission du phosphate (HPt) et des Régulateurs de Réponse (RR). L’implication d’un tel système dans la transduction du signal de la contrainte osmotique est avérée chez la levure et fortement suspectée chez Arabidopsis. Ce travail de thèse visait d’une part à caractériser l’implication de cette voie de transduction de la contrainte osmotique chez le peuplier, avec l’identification de partenaires HPt et RR en aval du récepteur HK1 et d’autre part à caractériser le mode de fonctionnement d’un RR de type-B. HK1, un osmosenseur membranaire détecterait le signal et le transmettrait à trois HPt préférentielles. De plus, un partenariat d’interaction se dégagerait entre ces trois HPt et certains RR-B. La régulation transcriptionnelle observée lors d’une contrainte osmotique pour deux des représentants des RR-B témoigne d’une possible implication de ces RR dans cette voie. Ces protéines sont des facteurs de transcription dont la fonction a été confirmée in planta pour l’un d’entre eux. La dimérisation du domaine receveur du RR et son interaction avec le domaine de fixation à l’ADN ou domaine GARP apparaissent comme des points de contrôle clés dans la régulation de l’activité effectrice des RR-B. De plus, la capacité d’un RR-B à se fixer sur ses motifs de reconnaissance (boîtes AGAT) a pu être vérifiée in vitro et la présence de ces séquences a d’ailleurs été retrouvée dans des gènes régulés par la contrainte osmotique. Ce travail prospectif ouvre des perspectives concernant l’implication des RR-B dans la voie de transduction du signal de la contrainte osmotique, et propose notamment des mécanismes fins pour l’élaboration d’une réponse hautement spécifiqueMultistep His-to-Asp phosphorelay systems are signaling pathways devoted to signal perception and transduction for establishment of specific responses. These systems are composed of three successive partners: Histidine-aspartate Kinases (HKs), Histidine-containing Phosphotransfer proteins (HPts), and Response Regulators (RRs). One of the best characterized corresponding systems is the osmo-responsive pathway in yeast. Such systems are also suspected in Arabidopsis. This work aimed to characterize the involvement of an osmosensing pathway in Populus by identifying HPt and RR elements downstream of HK1 and to reveal the underlying mechanisms for the activity of a RR-B. HK1, membrane osmosensor, is expected to be responsible for signal detection and propagation by triggering the activation of three preferential HPt. Furthermore, an interacting partnership between those HPts and particular B-type RRs was observed. Two of them appear to be regulated by an osmotic stress, suggesting their possible involvement in this pathway. The B-type RR members, the final output elements of the pathway, act as transcription factors, as shown for at least for one of them in planta. Taken together, the dimerization of the RR receiver domain and its interaction with its DNA binding domain (GARP), are likely key checkpoints in the regulation of RR-B activity. Besides, the ability of one RR-B to bind its cognate specific DNA sequences (AGAT boxes) was confirmed in vitro and those were found in promoters of osmotic response genes. This work opens up prospects for the involvement of RR-B in the osmotic stress signaling pathway and suggests mechanisms tuning induction of specific responses
46
Luddeni, Giovanni. "Improvement of a simulation platform for Helicon Plasma Thrusters: analysis of the boundary conditions and modelling of the sheath". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/24296/.
Abstract (sommario):
The proper treatment of the boundary conditions when dealing with fluid simulations of plasma processes constitutes a non-negligible issue that might affect the results, especially when dealing with plasma sources for propulsion applications, e.g., as in Helicon Plasma Thrusters (HPT). In this work, we handle the problem of boundary conditions modelling. Firstly, we have reviewed several established physical models to assess how to properly treat the HPTs. Then, three approaches to account for the sheath have been considered, namely, I) the direct solution of the sheath region through the finite volume discretization, II) the modelling of the sheath through analytical solutions, and III) a hybrid approach in which we coupled two distinguished solvers that handle respectively the bulk region of the plasma and the sheath.
The bulk region solver is based on the classical multi-fluid approach. The sheath is solved either by a fluid or a Lagrangian approach, to account for deviations from the Maxwellian velocity distribution function for each species present in the plasma. The proposed approaches have been tested in terms of plasma profiles (e.g., density) against the experimental case of a Piglet reactor. Generally, all three approaches have given a satisfactory agreement with the experimental measurements. In particular, the first and third approaches have shown similar results, with the latter being assessed with the fluid approach only. As for the computational cost, both methods required similar computation time. Regarding the second approach, the results under-estimate the plasma density if compared to the other methods. Nonetheless, this approach required 97% less computational effort. Ultimately, the hybrid approach achieved good results and it offers interesting possibilities of further development, some of which have been discussed.
47
Pizarro, Torres Francisco. "Potentialités d’un plasma hors-équilibre localisé pour la réalisation d’antennes imprimées reconfigurables ou autolimitantes". Thesis, Toulouse, ISAE, 2013. http://www.theses.fr/2013ESAE0048/document.
Abstract (sommario):
Le plasma est un gaz ionisé qui possède des caractéristiques physiques intéressantes dans le domaine des hyperfréquences. En simplifiant, on peut le caractériser comme un milieu diélectrique dispersif dont la permittivité est fonction de deux paramètres : la pulsation plasma (wp) et la fréquence de collision électron-neutre (Vp). En pratique, ces paramètres dépendent principalement de la densité électronique du gaz et de sa pression. Ainsi, en contrôlant les caractéristiques du plasma, on contrôle sa permittivité diélectrique, ce qui permet d’envisager son application dans le domaine de la reconfigurabilité en hyperfréquence.Parmi les topologies pouvant générer une décharge plasma, nous nous sommes focalisés sur l’utilisation de topologies récentes, à savoir les microdécharges plasma. Ces microdécharges sont intéressantes de par leur facilité d’intégration dans un dispositif RF : petite taille, stabilité, température proche de la température ambiante et perspectives d’utilisation à plus haute pression, voire à la pression atmosphérique.Devant la difficulté de modéliser précisément l’effet du plasma sur une onde guidée, une approche expérimentale a été privilégiée. Deux dispositifs de mesure ont ainsi été conçus pour caractériser cette interaction : une ligne de transmission microruban classique et une inversée intégrant une microdécharge en leurs centres. Grâce au protocole expérimental mis en œuvre, les paramètres S de la ligne de transmission sont obtenus et comparés à ceux des lignes sans plasma dans une large gamme paramétrique, qu’il s’agisse de la pression du gaz, de la fréquence ou encore du courant injecté à la décharge. Les résultats obtenus montrent deux phénomènes particulièrement intéressants: un déphasage de l’onde électromagnétique en présence de la décharge plasma et / ou une absorption importante de la puissance par la décharge.Deux dispositifs antennaires ont finalement été conçus en exploitant ces résultats. Le premier est une antenne imprimée accordable en fréquence dans une plage de l’ordre du pourcent, grâce à une décharge plasma contrôlée.Le plasma modifie alors la constante diélectrique entre les deux conducteurs constitutifs de l’antenne. Le second dispositif est une antenne anneau imprimée qui peut protéger son récepteur d’une attaque microondes de forte puissance. Ainsi, lorsqu’un champ incident dépasse un seuil prédéfini, réglable dans une certaine mesure par une tension continue externe, une décharge plasma apparaît au sein de l’élément rayonnant. Elle crée alors de la désadaptation et de l’absorption qui limitent de façon non linéaire la puissance restituée à l’accèsPlasma is an ionized gas with physical characteristics that are of interest to the microwave domain. To simplify, we can characterize it as a dispersive medium whose dielectric permittivity depends on two parameters :the plasma pulsation wp and the electron-neutral collision frequency Vp. These two parameters depend mainly on the electron density of the gas and its pressure. If we can control the characteristics of the plasma, we can also control its dielectric permittivity, which allows us to consider the plasma for applications in the field of microwave reconfigurability.Among the structures that can generate a plasma discharge, we have focused on the use of recent topologies,known as plasma microdischarges. These microdischarges are of interest because of the possibility of easily integrating them into a RF device : small size, stability, temperature near room temperature and potential use at high pressures, including at atmospheric pressure.Given the difficulties in accurately modelling the effects of the plasma on a guided wave, an experimental approachwas preferred. Two measuring devices have been designed to characterize this interaction : a conventional microstrip transmission line and an inverted microstrip transmisison line, both including a microdischarge in their centers. With this experimental characterization, the S-parameters of the transmission line with the plasma are obtained and compared to those without plasma as a function of a wide range of parameters, such as gas pressure,frequency and current injected into the discharge.The results show two particularly interesting phenomena : a phase shift of the electromagnetic wave in presence of the plasma discharge and/or an important absorption of the incident power by the discharge. Two devices have been designed to exploit these results. The first is a frequency tunable microstrip patch antenna over a range of the order of one percent. In that case, the plasma changes the dielectric constant between the two conductors of the antenna. The second is a microstrip ring patch antenna that can protect the receiver from a high-power microwave (HPM) attack. When an incident electric field exceeds an adjustable preset threshold (tuned by an external DCvoltage source), a plasma discharge appears in the radiating element. The plasma then creates a mismatch and an absorption effect that limits, in a non-linear way, the received power at its input
48
GHIANI, LAVINIA. "THE HISTONE POST-TRANSLATIONAL MODIFICATION LANDSCAPE IN HPV+ AND HPV- HEAD AND NECK SQUAMOUS CELL CARCINOMA: CHARACTERIZING THE ONCOGENIC ROLE OF THE H3K36ME2 METHYLTRANSFERASE NSD2". Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/820678.
Abstract (sommario):
Background: HNSCC is a heterogeneous group of tumors caused mainly by environmental factors and human papillomavirus (HPV) infections. HPV- and HPV+ HNSCC are considered distinct entities, however, they are still treated with the same therapeutic strategies. HPV-induced tumorigenesis is mainly mediated by the E6/E7 oncoviral proteins, that, among all, alter the epigenetics of the host cells. Nevertheless, epigenetic profiles of HNSCC subtypes have not been clearly profiled.
Results and Conclusion: hPTMs super-SILAC analysis of HNSCC cell lines and patients’ tissue samples revealed significant differences in the enrichment levels of some hPTM in HPV+ samples compared to HPV- ones and in tumoral tissues compared to normal ones.
We focused on one of these identified hPTM and demonstrated that its levels are regulated by E6 and E7. We identified a histone modifier responsible for this hPTM whose levels are upregulated by E6/E7 and are higher in HPV+ compared to HPV- HNSCC cell lines and patients’ tissue samples, as is for the related hPTM. Silencing this enzyme through shRNA in HNSCC cell lines reduced proliferation and migration rates in both subtypes. It also downregulates the expression levels of some EMT mesenchymal makers and of a crucial oncogene involved in HNSCC. RNA-seq analysis revealed that other programs are instead specifically regulated according to the subtype: immune-response related genes are mainly activated in HPV- cell lines, while genes involved in cell differentiation in the HPV+ ones. Our research paves the way to novel lines of research and identifies a promising novel epigenetic target for HNSCC treatments.
49
Cavanagh, Thomas. "THE KIOSK CULTURE: RECONCILING THE PERFORMANCE SUPPORT PARADOX IN THE POSTMODERN AGE OF MACHINES". Doctoral diss., University of Central Florida, 2006. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3793.
Abstract (sommario):
Do you remember the first time you used an Automatic Teller Machine (ATM)? Or a pay-at-the-pump gas station? Or an airline e-ticket kiosk? How did you know what to do? Although you never received any formal instruction in how to interact with the self-service technology, you were likely able to accomplish your task (e.g., withdrawing or depositing money) as successfully as an experienced user. However, not so long ago, to accomplish that same task, you needed the direct mediation of a service professional who had been trained how to use the required complex technology. What has changed? In short, the technology is now able to compensate for the average consumer's lack of experience with the transactional system. The technology itself bridges the performance gap, allowing a novice to accomplish the same task as an experienced professional. This shift to a self-service paradigm is completely changing the dynamics of the consumer relationship with the capitalist enterprise, resulting in what is rapidly becoming the default consumer interface of the postmodern era. The recognition that the entire performance support apparatus now revolves around the end user/consumer rather than the employee represents a tectonic shift in the workforce training industry. What emerges is a homogenized consumer culture enabled by self-service technologies--a kiosk culture. No longer is the ability to interact with complex technology confined to a privileged workforce minority who has access to expensive and time-consuming training. The growth of the kiosk culture is being driven equally by business financial pressures, consumer demand for more efficient transactions, and the improved sophistication of compensatory technology that allows a novice to perform a task with the same competence as an expert. "The Kiosk Culture" examines all aspects of self-service technology and its ascendancy. Beyond the milieu of business, the kiosk culture is also infiltrating all corners of society, including medicine, athletics, and the arts, forcing us to re-examine our definitions of knowledge, skills, performance, and even humanity. The current ubiquity of self-service technology has already impacted our society and will continue to do so as we ride the rising tide of the kiosk culture.Ph.D.
Department of English
Arts and Humanities
Texts and Technology PhD;
50
Quedas, Elisangela Pereira de Souza. "Análise do proto-oncogene RET em pacientes com carcinoma medular de tireóide e megacólon congênito de uma família com mutação germinativa p.C620R". Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-11012012-152825/.
Abstract (sommario):
As Neoplasias endócrinas múltiplas (NEMs) são síndromes herdadas de modo dominante e causadas por mutações germinativas em genes específicos. Caracterizam-se pela presença de tumores em um conjunto de glândulas endócrinas, conjunto este típico de cada tipo-específico de NEM. Dentre os diferentes tipos de NEMs, há a neoplasia endócrina múltipla tipo 2 (NEM2) que envolve os fenótipos, carcinoma medular de tireóide (CMT), hiperparatiroidismo primário (HPT), feocromocitoma (FEO) e megacólon congênito (doença de Hirschsprung, HSCR). Apesar da prevalência da NEM2 na população em geral ser baixa (~ 1:30.000), o número de casos afetados por família pode ser expressivo, uma vez que sua penetrância é praticamente completa (~100%). A doença de HSCR ou aganglionose intestinal congênita quando ocorre está geralmente associada à mutações RET nos códons 609, 618 e 620; apresenta ampla variação fenotípica, padrão de herança complexa e baixa penetrancia. Poucos casos de HSCR podem apresentar mutações em outros genes. Mutações no gene RET são responsáveis por aproximadamente metade (~50%) dos casos familiares de HSCR e alguns casos esporádicos (~10-20%), sugerindo fortemente que a HSCR seja doença poligenica. Tem-se também sugerido que polimorfismos genéticos no RET podem influenciar o fenotipo da NEM2/HSCR. No presente estudo, analisamos o gene RET no sentido de investigar se o desenvolvimento de megacólon em pacientes com a mutação germinativa RET p.C620R estaria associado à presença de ou a) a uma segunda mutação germinativa ou b) a um SNP, ou c) a um haplótipo informativo, que possivelmente poderia estar potencialmente interagindo genicamente com a mutação RET principal e eventualmente modulando o fenótipo HSCRThe multiple endocrine neoplasias (MENs) are inherited multi-tumoral conditions caused by germline mutations in specific genes. Specifically, the multiple endocrine neoplasia type 2 (NEM2) is a hereditary endocrine disorder transmitted dominantly and involving three main tumors, medullary thyroid carcinoma (CMT), primary hyperparathyroidism (HPT) and pheochromocytoma (PHEO). Despite the low prevalence of MEN2 in general population, the number of affected individuals per family can be significant as the penetrance of MEN2 is almost complete (~100%). In addition to CMT, PHEO and HPT, other conditions as congenital megacólon (Hirschsprung disease, HSCR or congenital intestinal aganglionosis) may occur in MEN2 (HSCR/MEN2). HSCR/MEN2 usually is due to RET mutations in codons 609, 618 and 620. HSCR has a wide phenotypic variation; is a complex multigenic disease; and has a low penetrance. Mutations in the RET gene are responsible for approximately 50% of the familial HSCR cases and ~10% of the sporadic HSCR cases, supporting that HSCR is a polygenic disease and this is confirmed by a few HSCR cases associated with mutations in the EDNRB and EDN3 genes. In the present study, we focused in the analysis of the RET gene in order to investigate whether the development of congenital megacólon in patients with RET mutation p.C620R is associated with the presence of, a) a second RET germline mutation, b) a SNP, or with a haplotype that co-segregate with the disease