Bibliografie tematiche / HIT

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Letteratura scientifica selezionata sul tema "HIT"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 11 marzo 2023

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Articoli di riviste sul tema "HIT"

Gedo, John E. "A Hit, a Hit, a Palpable Hit!" Contemporary Psychology: A Journal of Reviews 36, n. 10 (ottobre 1991): 845–46. http://dx.doi.org/10.1037/030239.

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Prechel, Margaret, Abigail M. Hilby e Jeanine M. Walenga. "Cross Reactivity of Heparin-Induced PF4 Antibodies with Heparin- Bound IL-8." Blood 112, n. 11 (16 novembre 2008): 3429. http://dx.doi.org/10.1182/blood.v112.11.3429.3429.

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Abstract Background: Heparin-Induced Thrombocytopenia (HIT) is caused by polyclonal antibodies, formed to conformational neoepitopes exposed in platelet factor 4 (PF4) bound to heparin (H). HIT antibodies are commonly measured by one of several commercially available ELISAs. The literature reports cases of clinical HIT and/or positive HIT antibody-mediated platelet activation tests in patients without antibodies detectable in PF4 based ELISAs, and suggests that antibodies to other chemokines, such as interleukin-8 (IL-8), may be involved. The current study was undertaken to characterize the frequency of such antibodies in a population of consecutive serum specimens submitted for HIT diagnosis by 14C-serotonin release assay (SRA), and also in a group of retrospectively selected SRA-positive specimens. Methods: Specimens (n=90) analyzed by SRA between March and July 2008 were subsequently tested by PF4 Enhanced ELISA (GTI, Waukesha, WI), and the Zymutest HIA ELISA (Hyphen BioMed, Neuville sur Oise, France). An additional ELISA was carried out on the specimens using the Zymutest heparin-bonded plate coated with purified, recombinant human interleukin-8 (IL-8) (72 aa form, Prospec, Rehovot, Israel). The second group consisted of archived specimens (n=32) that tested positive by SRA but negative by GTI HAT ELISA; these specimens were subsequently tested by the Zymutest HIA and the H:IL-8 ELISA. Results: Recombinant IL-8 (1μg/well) added to heparin-bound ELISA plates was recognized by anti-IL-8 (BD Biosciences), but not anti-PF4 (Leinco Technologies, Inc.) antibodies and was not displaced from the plate by addition of PF4 from normal serum at the dilution (1:100) used in the ELISA. Of the 90 consecutive specimens, 21 (23.3%) tested positive in both the GTI and the Zymutest HIA tests; 15 of the 90 (16.6%) tested positive by one but not both of the PF4-based ELISAs (Table 1). In this group of 90 specimens, 17 (18.9%) had OD > 0.500 on the heparin-bound IL-8 plate. Only 3 of the specimens bound to the H:IL-8 exclusively, while 14 were also positive in the GTI and/or Zymutest HIA ELISA. Thus, of the 36 specimens that tested positive in one or both of the PF-4-based ELISAs, 14 (38.9%) had antibodies that also targeted heparin-bound IL-8. Ten of the 90 specimens tested positive in the SRA. Six of SRA-positives had PF4-specific antibodies that did not cross react with H:IL-8, 3 had H:IL-8 reactive antibodies in addition to PF4 reactive antibodies, and 1 SRA positive specimen tested negative in all ELISAs. Table 1. Comparison of GTI HAT vs Zymutest HIA results: n = 90 consecutive patients Numbers in parentheses indicate how many specimens in each subgroup contained antibodies that bound to H:IL-8. Zymutest HIA + − Total + 21 (11) 9 (1) 30 GTI HAT − 6 (2) 54 (3) 60 Total 27 63 90 Among the set of 32 specimens that tested positive by SRA and negative by GTI ELISA, 8 tested positive in the Zymutest ELISA, including 4 that had OD > 0.500 on the H:IL-8 plate. The 24 specimens that tested negative by both HIT ELISAs ranged in percent serotonin release (tested with 0.1 U/ml H) between 21–84% with a median of 45.6%, and did not contain antibodies that bound the H:IL-8 plate. Conclusions: The data agree with other studies that show differences between results of commercially available HIT ELISA kits. The study also shows that over one third of specimens that test positive in the HIT ELISAs contain antibodies that are not specific for PF4, but also recognize heparin-bound IL-8. These results do not prove that the antibodies that bind PF4 targets are the same ones that bind IL-8. However, the significant degree of homology (40%) between the peptides suggests that the same antibodies may cross react with either target. The relevance of these antibodies is as yet unclear. Only 3% of specimens bound H:IL-8 plates but not PF4 plates, and these were not associated with SRA activity. Also HIT ELISA negative specimens with SRA activity, which showed only moderate percent serotonin release, did not contain H:IL-8-binding antibodies. The study did not find evidence of a role for H:IL-8 antibodies in HIT-related platelet activation tests.

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Pouplard, Claire, Sandra Regina, Jean Baptiste Valentin e Yves Gruel. "A New Enzyme Immuno-Assay That Only Detects IgG Antibodies to Heparin-PF4 Complexes (Zymutest HIA IgG®) Improves the Specificity of the Diagnosis of HIT without Loss of Sensitivity." Blood 110, n. 11 (16 novembre 2007): 2096. http://dx.doi.org/10.1182/blood.v110.11.2096.2096.

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Abstract Heparin-induced thrombocytopenia (HIT) is associated in most patients with the development of antibodies to heparin-modified platelet factor 4 (PF4). Commercial immuno-assays frequently detect these antibodies after cardiac surgery but only few patients develop clinical HIT. Therefore, platelet activation tests such as serotonin release assay (SRA) are necessary to ensure the diagnosis of HIT with high specificity. Another approach to increase diagnosis specificity could be to detect IgG antibodies which are of major clinical relevance since they are the only class able to directly activate platelets in the presence of heparin. Therefore, we evaluated the performances of a new commercial immuno-assay specific to IgG for the diagnosis of HIT Abs (Zymutest HIA IgG®, Hyphen Biomed, Neuville sur Oise, France). Samples from 101 patients with suspected HIT were analysed. 40 cases had developed significant levels of Abs to PF4 measured with PVS/PF4 ELISA (HAT45®,GTI, Brookfiled, WI, USA) and the diagnosis of HIT had been confirmed since SRA was positive. Every sample was then tested with a global assay named Zymutest HIA G/A/M® as followed: each diluted plasma (200 μl) was incubated for 1 hour with 50 μl of platelet lysate providing PF4 into wells previously coated with unfractionated heparin. After washings and incubation (1 hour) with anti IgG/A/M-HRP immunoconjugate, the enzyme activity was developed and absorbance was read at 450nm. In case of positive result (A450 ≥ 0.5), the isotype distribution was analysed with a specific and standardized assay using monospecific anti-IgG-, anti-IgA- and anti IgM-HRP conjugates (Zymutest HIA-IgG® or -IgA® or -IgM®). A450 values ≥ 0.5 were also considered as positive. GTI assay that detected IgG/A/M Abs to PVS/PF4 complexes in the 40 patients with HIT (Ss 100%) was also positive in 30 of the 61 cases with no HIT (Sp 50.8%). Comparatively, Zymutest HIA® global assay was positive in 39 of the 40 patients with HIT (Ss 97.5%) and in 14 of 61 cases without HIT (Sp 77%). On the other hand, significant levels of heparin-dependent IgG antibodies were also measured in these 39 HIT patients using Zymutest HIA IgG® assay (mean A450: 1.81; range A450: 0.5 – 2.76), and only in 6 patients without HIT (Sp: 90%). However, IgG levels measured in patients without HIT were significantly lower (mean A450: 0.60; range A450: 0.08 – 2.20) than in those with HIT (p < 0.0001). In addition, IgA or IgM heparin-dependent antibodies were only present, i.e. without IgG, in samples from patients for whom the diagnosis of HIT had been ruled out (n = 3). In conclusion, this study supports that the detection of significant levels of IgG heparin-dependent antibodies improves the diagnosis specificity in patients with a suspicion of HIT without loss of sensitivity. Nonetheless, whether IgG-specific immunoassays could avoid to perform platelet activation tests in patients with a strong pre-test probability of HIT warrant further study.

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Patrick, Jon D., e Susan Ieraci. "Good HIT and bad HIT". Medical Journal of Australia 198, n. 4 (marzo 2013): 205. http://dx.doi.org/10.5694/mja12.11350.

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Jones, George Fenwick. "Hit's Hard to Hit Hit". English Language Notes 41, n. 1 (1 settembre 2003): 80–82. http://dx.doi.org/10.1215/00138282-41.1.80.

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Ogden, Jeff. "Hit first and hit hard". Infosecurity Today 1, n. 1 (gennaio 2004): 32–34. http://dx.doi.org/10.1016/s1742-6847(04)00020-5.

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Warkentin, Theodore E., e Mark A. Crowther. "When is HIT Really HIT?" Annals of Thoracic Surgery 83, n. 1 (gennaio 2007): 21–23. http://dx.doi.org/10.1016/j.athoracsur.2006.07.006.

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Pouplard, Claire, Dorothée Leroux, Sandra Regina, Jérôme Rollin e Yves Gruel. "Effectiveness of a new immuno-assay for the diagnosis of heparin-induced thrombocytopenia and improved specificity when detecting IgG antibodies". Thrombosis and Haemostasis 103, n. 01 (2010): 145–50. http://dx.doi.org/10.1160/th09-04-0253.

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SummaryThe diagnosis of heparin-induced thrombocytopenia (HIT) is based on clinical criteria and biological assays. Most immunoassays detect antibodies (either IgG alone or additionally IgA and IgM) against PF4 immobilised in wells of microtiter plates with stoichiometric concentrations of polyanion (heparin or polyvinylsulfonate). We studied whether diagnostic sensitivity and/or specificity for HIT could be improved using a novel assay in which unfractionated heparin is immobilised alone to the microwells, with PF4 (and, potentially, other heparin-dependent antigen proteins) provided by adding platelet lysate during the procedure. Samples from 101 patients with suspected HIT and from 101 controls (including 50 with antiphospholipid antibodies) were tested. The global assay (Zymutest HIA IgG/A/M®, Hyphen BioMed) was positive for 39 of 40 patients with definite HIT (positive PF4-specific ELISA and positive serotonin release assay). It was positive in only two of the 101 control patients studied and also in 14 of the 61 patients with suspected HIT for whom the disease was excluded (specificity (sp): 77%). On the other hand, Zymutest HIA IgG®, an IgG-specific assay, was positive in only six patients without HIT (Sp: 90%). Heparin-dependent IgG antibodies were present at higher levels in patients with definite HIT than in those for whom the diagnosis of HIT was ruled out. A single ELISA that detects IgG antibodies is more effective for the diagnosis of HIT in clinical practice. These results also support the hypothesis that heparin-dependent antibodies of IgG class have a major role in the pathogenesis of HIT.

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Range, Melissa. "Hit". Ecotone 9, n. 2 (2014): 149–50. http://dx.doi.org/10.1353/ect.2014.0019.

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WOODRUFF, DAVID W. "HIT". Nursing Made Incredibly Easy! 4, n. 1 (gennaio 2006): 53–55. http://dx.doi.org/10.1097/00152258-200601000-00009.

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Tesi sul tema "HIT"

Rafferty, Eileen N. "Jimmy Hit His First Home Run". VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/958.

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This document begins with the end of a life and ends with the beginning of hope. It is a brief description of the artist's history, artistic and literary influences, and subsequent works produced during graduate school, specifically Dichotomy, Swan Dive, and Jimmy Hit His First Home Run. Topics discussed include Human Physiology, Transference, Buddhism, and Bubbles. This document was created in Microsoft Word 2004 for Mac, Version 11.2.

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Dankovich, James Edmund. "Make Hit Phlegm". Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/30892.

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This thesis is an application of surrealism to architecture. Surrealism is an art & literary movement started in Europe between the world wars. After the chaos of the first world war the surrealist group was disillusioned with the devotion to rationalism that they believed produced the war. The group determined that an opposing philosophy would produce the opposite result. They began to develop an art based on the irrational. Their creativity was derived from chance, group activities, dreams, and other undirected actions. They promoted this as a new way to discover beauty and a foundation for a new way of thinking. The surrealists were prevalent in art and literature, but never integrated themselves into the world of architectural design. This thesis explores the possibilities of using surreal concepts and techniques as an inspiration for design. The site for this exploration is a fifty foot wide infill lot in an urbanizing Washington, D.C. suburb, Falls Church, Virginia. The art schoolâ s program was selected by a Wikipedia random article search and a deck of cards.
Master of Architecture

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Bright, Kerrin John. "Fragment-based hit discovery". Thesis, University of York, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516627.

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Mattingly, Stacy. "The hit and other writing". Thesis, Boston University, 2012. https://hdl.handle.net/2144/32034.

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Thesis (M.F.A.)--Boston University. Please note: creative writing theses are permanently embargoed in OpenBU. No public access is forecasted for these. To request private access, please click on the locked Download file link and fill out the appropriate web form.
2031-01-02

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Reiman, Minna, e Philippa Örnell. "Predicting Hit Songs with Machine Learning". Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-229705.

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Exploring the possibility of predicting hit songs is both interesting from a scientific point of view and something that could be beneficial to the music industry. In this research we raise the question if it is possible to classify a music track as a hit or a non-hit based on its audio features. We investigated which machine learning algorithms could be suited for a task like this. Four different models were built using various algorithms such as Support Vector Machine and Gaussian Naive Bayes. The obtained results do not indicate that it is possible to predict hit songs on our particular dataset. This stands in contrast to some previous research within this field. We discuss the potential problem in using only audio features, and how this seems not to be sufficient information for predicting a hit.
Att förutsäga om en låt når topplistan skulle vara gynnsamt för musikindustrin samtidigt som det är intressant ur ett vetenskapligt perspektiv. I vår undersökning lyfter vi frågan om det är möjligt att klassificera en låt som hit eller icke-hit baserat på låtens ljudegenskaper. Vi utreder vilka algoritmer för maskininlärning som kan vara lämpliga för denna uppgift. Fyra olika modeller byggs utifrån algoritmer såsom Support Vector Machine och Gaussian Naive Bayes. De uppmätta resultaten indikerar att det inte är möjligt att förutsäga en hit på den utvalda datamängden. Dessa resultat motsäger en del av den tidigare forskningen gjord inom detta ämne. Vi diskuterar det potentiella problemet i att bara att analysera ljudegenskaper och hur detta inte tycks vara tillräcklig information för att identifiera en hit.

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Xi, Yongli Lily. "Analytical modeling for buffer hit rate prediction". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ63393.pdf.

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Kom, Brian S. R. "Tuning In to a Hit Parade Pedagogy". Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30559.

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Contemporary popular music is a ubiquitous social, cultural, and pedagogical force. Enabled by ever-evolving and -expanding technology, its songs and lyrics are transmitted into our most public and private spaces. For this study, I present the Billboard music charts as a functioning pedagogy and curriculum. Riffing on Richter’s denkbilder, Aoki’s curricular worlds of plan and lived experience, Giroux’s public pedagogy, and Giroux & Simon’s theorizing on youth culture, I sound out messages and motives embedded within the hit parade pedagogy. DJing a methodology of qualitative inquiry, autoethnography, and free association, I listen closely to chart-topping songs by Lady Gaga, Katy Perry, and P!nk that feature themes of marginalization, and consider the paradox presented by the juxtaposition of their popularity and subject matter. I suggest that this playlist legitimizes and perpetuates its listeners’ marginalization, running counter to its supposed intent to galvanize and inspire. Before signing off, I consider the implications for school-based educators and pedagogy in regard to engaging marginalization, particularly the notion of implementing a curriculum with which students may participate and sing along.

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Caldwell, Anita M. "Hard Times Hit Elderly Harder Than Most". College of Agriculture, University of Arizona (Tucson, AZ), 1993. http://hdl.handle.net/10150/295717.

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Wirths, Christopher. "Funktionelle Charakterisierung des Histidin-Triaden (HIT)-Proteins Hint2". [S.l.] : [s.n.], 2006. http://www.diss.fu-berlin.de/2006/591/index.html.

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Zordan, Victor B. "Motion capture-driven simulations that hit and react". Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/8314.

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Più fonti

Libri sul tema "HIT"

Hit. London: MaxCrime, 2010.

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Furie, Sidney J., Harry Korshak, David M. Wolf e Alan Trustman. Hit! St. Charles, Ill.]: Olive Films, 2012.

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Strube, Henrik. Hit. [Copenhagen]: Lindhardt og Ringhof, 1989.

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Burton, Bob. Crimson hit. New York: Kensington Pub., 2004.

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Block, Lawrence. Hit parade. New York: HarperLargePrint, 2006.

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Jackson, Daniel M., Richard Jankovich, Eric Sheinkop e David Marcus. Hit Brands. London: Palgrave Macmillan UK, 2013. http://dx.doi.org/10.1057/9781137271488.

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Turner, Ann Warren. Hard hit. New York: Scholastic, 2006.

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Hit & run. New York: St. Martin's Press, 1989.

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Block, Lawrence. Hit man. New York: W. Morrow & Co., 1998.

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Block, Lawrence. Hit man. Thorndike, ME: Thorndike Press, 1998.

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Capitoli di libri sul tema "HIT"

Henry, Stephen. "Hit Him Again". In Doing Autoethnography, 95–104. Rotterdam: SensePublishers, 2017. http://dx.doi.org/10.1007/978-94-6351-158-2_10.

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Jeanne, Wendel, e O’Donohue William. "Hit = Emr + Hie". In Understanding Healthcare Economics, 197–209. Second edition. | Boca Raton : Taylor & Francis, 2018. | “A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.”: Productivity Press, 2017. http://dx.doi.org/10.4324/9781315193281-11.

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Cutrofello, Andrew. "‘Hit it, hit it, hit it’". In The Routledge Companion to Shakespeare and Philosophy, 460–72. Abingdon, Oxon ; New York, NY : Routledge, 2019.: Routledge, 2018. http://dx.doi.org/10.4324/9781315677019-32.

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Weik, Martin H. "hit". In Computer Science and Communications Dictionary, 729. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_8401.

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Zhang, Yixin. "Hit Identification and Hit Follow-Up". In A Handbook for DNA-Encoded Chemistry, 357–76. Hoboken, NJ: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118832738.ch16.

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Lubenow, N., e A. Greinacher. "HIT-Diagnostik". In Hämostaseologie, 857–60. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-01544-1_62.

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Tobias, Michael Charles. "The HIT". In Codex Orféo, 177. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30622-3_62.

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Weik, Martin H. "gain hit". In Computer Science and Communications Dictionary, 669. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_7859.

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Weik, Martin H. "hit ratio". In Computer Science and Communications Dictionary, 729. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_8403.

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Weik, Martin H. "line hit". In Computer Science and Communications Dictionary, 900. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_10278.

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Atti di convegni sul tema "HIT"

Zhao, Shiqi, Lin Zhao, Yu Zhang, Ting Liu e Sheng Li. "HIT". In the 4th International Workshop. Morristown, NJ, USA: Association for Computational Linguistics, 2007. http://dx.doi.org/10.3115/1621474.1621510.

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Bredeche, Nicolas. "HIT-EE". In GECCO '19: Genetic and Evolutionary Computation Conference. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3319619.3321928.

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Liu, PengYuan, TieJun Zhao e MuYun Yang. "HIT-WSD". In the 4th International Workshop. Morristown, NJ, USA: Association for Computational Linguistics, 2007. http://dx.doi.org/10.3115/1621474.1621509.

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Henze, Niels. "Hit it!" In the 2012 ACM annual conference extended abstracts. New York, New York, USA: ACM Press, 2012. http://dx.doi.org/10.1145/2212776.2212450.

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Zhou, Shusen, Qingcai Chen e Xiaolong Wang. "HIT-OR3C". In the 8th IAPR International Workshop. New York, New York, USA: ACM Press, 2010. http://dx.doi.org/10.1145/1815330.1815359.

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McInnis, Brian, Dan Cosley, Chaebong Nam e Gilly Leshed. "Taking a HIT". In CHI'16: CHI Conference on Human Factors in Computing Systems. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/2858036.2858539.

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Guo, Yuhang, Wanxiang Che, Yuxuan Hu, Wei Zhang e Ting Liu. "HIT-IR-WSD". In the 4th International Workshop. Morristown, NJ, USA: Association for Computational Linguistics, 2007. http://dx.doi.org/10.3115/1621474.1621508.

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Marino, Alex, e Greg Peltz. "Hit and run". In ACM SIGGRAPH 2009 Computer Animation Fesitval. New York, New York, USA: ACM Press, 2009. http://dx.doi.org/10.1145/1596685.1596745.

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Stevens, Joanna. "Offspring "Hit That"". In ACM SIGGRAPH 2004 Computer animation festival. New York, New York, USA: ACM Press, 2004. http://dx.doi.org/10.1145/1186015.1186088.

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Smith, Missie, Lisa Jordan, Kiran Bagalkotkar, Srikar Sai Manjuluri, Rishikesh Nittala e Joseph Gabbard. "Hit the Brakes!" In AutomotiveUI '20: 12th International Conference on Automotive User Interfaces and Interactive Vehicular Applications. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3409251.3411720.

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Rapporti di organizzazioni sul tema "HIT"

Meade, Roger Allen, e August Lawrence Keksis. The Rock that Hit New York. Office of Scientific and Technical Information (OSTI), ottobre 2016. http://dx.doi.org/10.2172/1329691.

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Kayaoglu, Barin. Turkish military hit by food poisoning scandal. Al-Monitor: The Pulse of the Middle East, giugno 2017. http://dx.doi.org/10.26598/auis_ug_is_2017_06_19.

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Knopp, Jeremy S., e Li Zeng. Statistical Analysis of Hit/Miss Data (Preprint). Fort Belvoir, VA: Defense Technical Information Center, luglio 2012. http://dx.doi.org/10.21236/ada565118.

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Mogul, J., e P. Leach. Simple Hit-Metering and Usage-Limiting for HTTP. RFC Editor, ottobre 1997. http://dx.doi.org/10.17487/rfc2227.

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M. Wallace. Number of Waste Package Hit by Igneous Intrusion. Office of Scientific and Technical Information (OSTI), ottobre 2004. http://dx.doi.org/10.2172/838330.

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P.E. Sanchez. Number of Waste Package Hit by Igneous Intrusion. Office of Scientific and Technical Information (OSTI), giugno 2005. http://dx.doi.org/10.2172/850428.

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Bunn, Fred. Hit Probability of a High Velocity Tank Round. Fort Belvoir, VA: Defense Technical Information Center, marzo 1993. http://dx.doi.org/10.21236/ada262846.

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Granja, João, Christos Makridis, Constantine Yannelis e Eric Zwick. Did the Paycheck Protection Program Hit the Target? Cambridge, MA: National Bureau of Economic Research, maggio 2020. http://dx.doi.org/10.3386/w27095.

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Kayaoglu, Barin. Turkish Political parties hit each other with coup allegations. Al-Monitor: The Pulse of the Middle East, agosto 2018. http://dx.doi.org/10.26598/auis_ug_is_2017_08_08.

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Jones, John, e Martin Ince. New potato varieties are a hit in East Africa. A cura di Sarah Bennison e Laura Pels Ferra. St Andrews Network for Climate, Energy, Environment and Sustainability (STACEES), 2021. http://dx.doi.org/10.15664/10023.24201.

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