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Letteratura scientifica selezionata sul tema "Histology"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 9 giugno 2025

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Articoli di riviste sul tema "Histology"

Shaw, Phyllis A., and Erica S. Friedman. "Clinico-Histologic Conferences: Histology and disease." Anatomical Sciences Education 5, no. 1 (December 5, 2011): 55–61. http://dx.doi.org/10.1002/ase.1252.

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Langer, Corey J., Benjamin Besse, Antonio Gualberto, Elizabeth Brambilla, and Jean-Charles Soria. "The Evolving Role of Histology in the Management of Advanced Non–Small-Cell Lung Cancer." Journal of Clinical Oncology 28, no. 36 (December 20, 2010): 5311–20. http://dx.doi.org/10.1200/jco.2010.28.8126.

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Until recently, non–small-cell lung cancer (NSCLC) was treated as a single disease despite recognition of its histologic and molecular heterogeneity. Recent clinical trials, however, demonstrate that histology is an important factor for individualizing treatment, based on either safety or efficacy outcomes. For example, the labeling of the licensed agents bevacizumab and pemetrexed is restricted to patients with nonsquamous cell NSCLC. For bevacizumab, this restriction is due to an apparent association between squamous cell histology and severe pulmonary hemorrhage, whereas for pemetrexed, superior treatment effects have been observed in patients with nonsquamous cell histology. Given fewer agents are both active and tolerable in patients with squamous cell carcinoma compared with adenocarcinoma, and the nature of this particular phenotype of NSCLC, new drugs are needed for this histology. In this new histology-based treatment era, questions persist. Can pathology accurately distinguish the histologic subtypes of NSCLC? Can we use cytologic diagnosis? In the future, will molecular profiling of tumors trump histologic analysis? Herein we describe how therapy for NSCLC is evolving on the basis of a better understanding of molecular mechanisms underlying NSCLC histologic heterogeneity and tumorigenesis.

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Tefferi, A., R. A. Zellers, P. M. Banks, T. M. Therneau, and J. P. Colgan. "Clinical correlates of distinct immunophenotypic and histologic subcategories of lymphocyte-predominance Hodgkin's disease." Journal of Clinical Oncology 8, no. 12 (December 1990): 1959–65. http://dx.doi.org/10.1200/jco.1990.8.12.1959.

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Histologic and paraffin immunohistologic studies were carried out on 32 patients with lymphocyte-predominance Hodgkin's disease (LPHD) seen from 1970 through 1982. While nodular histology was accurately predictive of B-cell phenotype (Leu M1 -/L26+), diffuse histology corresponded to either B-cell or Hodgkin's (Leu M1 +/L26-) phenotype, not invariably predictable even when attention was paid to subtle paragranuloma cytology. Clinical characteristics were compared between histologic (diffuse v nodular) and immunophenotypic (Leu M1 +/L26-, Hodgkin's phenotype, v Leu M1 -/L26+, B-cell phenotype) subgroups. Ten patients have since died, and the median follow-up of the living patients was 14 years (range, 6 to 31). Of the several clinical parameters compared, only axillary nodal presentation was strongly associated with both B-cell phenotype and nodular histology, while male predominance related more to B-cell phenotype than nodular histology. No significant difference in overall survival or relapse rate was apparent among either the histologic or the immunophenotypic subgroups. However, very late but salvageable relapses were associated with nodular histology. The incidences of secondary malignancies and death from Hodgkin's disease (HD) were also comparable between the subgroups. Although difference in clinical presentation may exist, neither the histologic nor the immunophenotypic subcategories of LPHD could be demonstrated to correlate with differences in clinical outcome.

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Vázquez, José. "Histology." American Biology Teacher 66, no. 6 (August 1, 2004): 454–55. http://dx.doi.org/10.2307/4451714.

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Curi, Rui. "Histology." Brazilian Journal of Pharmaceutical Sciences 47, no. 1 (March 2011): 196–97. http://dx.doi.org/10.1590/s1984-82502011000100031.

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DONNEZ, JACQUES, and FRANCOISE CASANAS-ROUX. "Histology." Obstetrical & Gynecological Survey 44, no. 4 (April 1989): 281–83. http://dx.doi.org/10.1097/00006254-198904000-00020.

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Jones, R. H., and C. A. R. Boyd. "Histology." Trends in Cell Biology 2, no. 4 (April 1992): 120. http://dx.doi.org/10.1016/0962-8924(92)90018-i.

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Cox, F. E. G. "Histology." Parasitology Today 8, no. 8 (August 1992): 290. http://dx.doi.org/10.1016/0169-4758(92)90159-y.

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Meyer, Harriet S. "Histology." JAMA 286, no. 1 (July 4, 2001): 95. http://dx.doi.org/10.1001/jama.286.1.95-jbk0704-1a-1.

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Tang, Ming, Neda Kalhor, Maheshwari Ramineni, Junya Fujimoto, Jianhua Zhang, Jun Li, Chi-Wan Chow, et al. "Histology determination of lung cancers: A report on genomic profiling of lung cancer of mixing histology." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 8570. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.8570.

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8570 Background: Histopathology, largely determined by morphology, plays a critical role in choosing appropriate treatment for lung cancer. The understanding of molecular determination of lung cancer histology is rudimentary. Our recently published data (Zhang, Science, 2014 and Liu, Nature Communications, 2016) have demonstrated that within the same patients with identical genetic background and identical exposure, tumor regions with different morphologic appearances may have very similar genomic profiles while tumors with the same morphology may have distinct genomic landscape. Methods: We collected 12 lung cancers of mixing histology with 2 to 4 histologic components within each tumor. In total, 26 tumor regions including 9 adenocarcinomas, 6 large-cell neuroendocrine carcinoma, 6 small cell carcinomas and 4 squamous cell carcinomas and one poorly differentiated lung carcinoma were microdissected and subjected to whole exome sequencing. Results: A substantial number of identical mutations were shared between different histologic components within the same tumor in all 12 patients. However, the proportion of shared mutations varies in different patients ranging from as little as 4% to as much as 99%. Mutation spectrum is also similar between different histologic components within the same tumors suggesting similar mutational process in place. Identical canonical cancer gene mutations including TP53, KRAS, PIK3CA, SOS1 and STK11 are generally shared between different histologic components within the same tumors. Canonical mutations in FBXW7 and MTHFR were detected in squamous component, but not small-cell component in one patient. Conclusions: Different histologic components of lung cancers of mixing histology are likely derived from the same progenitor cells, but the molecular timing of branch separation of subclones giving rise to different histologic components varies in different tumors. Although genomic aberrations may play a role in a subset of tumors, histologic features may not be determined at genomic level for most lung cancers. Gene expression and methylation analyses from these tumors are underway.

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Più fonti

Tesi sul tema "Histology"

Nacarino, Meneses Carmen. "Life history inferences in extant and extinct Equus from the histological analysis of bone and enamel tissues." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/664248.

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El estudio de life histories proporciona información sobre la biología y ecología de las especies, incluyendo las condiciones ecológicas de su ecosistema, su biodiversidad, su demografía y su vulnerabilidad. La life history de vertebrados actuales y extintos puede ser reconstruida a partir de la microestructura ósea y dental. Sin embargo, el estudio de mamíferos clave en paleontología y ecología, como los équidos, es aún escaso. La presente tesis doctoral tiene como objetivo analizar la histología ósea y dental de Equus actuales y extintos para inferir sus características biológicas y de life history más importantes. La muestra actual se compone de huesos y dientes de asno salvaje asiático, cebra común y cebra de Grevy. Su estudio ha proporcionado un marco sólido para el análisis de Equus fósiles, limitado en esta tesis a especies del Pleistoceno Medio y Superior. Los resultados obtenidos de histología ósea en équidos actuales muestran que el tipo de tejido varía a lo largo de la ontogenia, registrando el crecimiento del individuo. Los cambios de tejido óseo también se han relacionado con ciertas características de life history. Así, el cambio de hueso fibrolamellar a lamellar (external fundamental system) en fémures de équidos se ha visto asociado a la madurez reproductiva. Eventos clave del ciclo vital, como el nacimiento, quedan igualmente registrados en el tejido óseo de los équidos. Por primera vez en mamíferos, esta tesis doctoral describe una marca de crecimiento no cíclica en huesos apendiculares, cuya deposición está relacionada con una reducción/parada del crecimiento en los potros durante el nacimiento (línea neonatal). Este descubrimiento es de gran importancia para la reconstrucción histológica de life histories en mamíferos actuales y extintos. El estudio esqueletocronológico en Equus actuales ha revelado, además, que el fémur es el mejor hueso para obtener datos de life history y que las curvas de crecimiento reflejan la madurez esquelética. Por otro lado, el contaje de marcas diarias en el esmalte de équidos actuales ha proporcionado nuevas tasas de secreción que invalidan estudios incorrectos previos. El estudio del esmalte dental realizado en primeros molares inferiores de Equus indica, además, que el desarrollo de este diente consta de tres fases. Cada una de ellas presenta un patrón y una tasa de crecimiento específica, y está relacionada con modificaciones ontogenéticas y estructurales del diente. Asimismo, el análisis histológico muestra que el esmalte se extiende más allá del cérvix, dificultando la toma de medidas de la altura de la corona a partir de la apariencia externa del diente. Los resultados obtenidos indican, también, que el desgaste del primer molar es mucho más pronunciado en etapas tempranas de la ontogenia, y que la corona de este diente tarda en formarse el doble de tiempo en el asno asiático que en las cebras africanas debido, probablemente, a diferencias en hábitat y longevidad entre especies. Además, se ha analizado la histología ósea de las especies del Pleistoceno Medio E. steinheimensis y E. mosbachensis y el esmalte dental de las del Pleistoceno Superior E. ferus y E. hydruntinus, en un primer intento por reconstruir la life history de Equus fósiles. Esto, a su vez, ha permitido analizar los cambios evolutivos de tamaño corporal descritos en Equus durante el Pleistoceno europeo bajo una perspectiva de life history. Los resultados preliminares obtenidos en esta tesis indican que los équidos más grandes del Pleistoceno Medio crecían a tasas más elevadas que las especies del Pleistoceno Superior y actuales, más pequeñas. Este resultado se corresponde con reconstrucciones paleoambientales y con modelos teóricos de life history que proponen la disponibilidad de recursos como una de las presiones de selección más importantes en la determinación del tamaño corporal. The study of life histories provides valuable insights into many aspects of a species’ biology and ecology, including the ecological conditions of its ecosystem, its biodiversity, its demography and its vulnerability to extinction. Life histories of extant and extinct vertebrates can be reconstructed from bone and dental microstructure. However, histological research in key mammalian groups for paleontology and ecology, such as equids, is still little explored. The present PhD thesis aims to analyze bone and dental histology in extant and extinct Equus to obtain information about their most important life history and biological traits. The extant sample of the present dissertation comprises bones and teeth of Asiatic wild ass, plains zebra and Grevy’s zebra. Their detailed histological study has provided a solid framework for the subsequent analysis of fossil Equus species, which has been limited here to Middle and Late Pleistocene taxa. Results obtained from bone histology in living equids show that bone tissue types vary through ontogeny, recording individual growth. This dissertation also indicates that changes in bone tissue types are related to certain life history characteristics. Thus, for instance, results of this thesis reveal that the transition from fibrolamellar to lamellar bone (i.e. external fundamental system) in equid femora is associated with the onset of reproductive maturity. Key life history events, such as the moment of birth, are also registered in the bone tissue of equids. For the first time in mammals, the present dissertation describes a non-cyclical bone growth mark in the limb bones of equids whose timing of deposition agrees with a period of growth arrest/decline during birth in foals (neonatal line). This discovery is of high importance for the histological reconstruction of life histories in extant and extinct mammals. Bone skeletochronology in extant Equus further reveals that the femur is the best bone to obtain life history data in equids, and that bone growth curves yield information about skeletal maturity. On the other hand, the counting of incremental markings of daily periodicity in equid enamel yields new estimates of daily secretion rates for these mammals that invalidate previous inaccurate studies. The detailed study of dental enamel in first lower molars of extant Equus also shows that the development of this tooth involves three different stages. Each of them presents a specific rate and pattern of growth, and is related to ontogenetic and structural modifications of the tooth. The histological analysis performed here further indicates that enamel extends beyond the molar’s cervix in equids, hampering measurements of the crown height from the external appearance of the tooth. Results of this thesis also reveals that the time of first lower molar crown formation in the Asiatic wild ass doubles that of the African zebras, probably due to differences in habitat and longevity among these species. Dental histology further yields information about rates of wear in equids, indicating much higher wear rates for the first lower molar early in ontogeny than commonly thought. In a first attempt to reconstruct the life history of extinct Equus, bone histology was analyzed in the Middle Pleistocene species E. steinheimensis and E. mosbachensis and dental enamel was studied in the Late Pleistocene taxa E. ferus and E. hydruntinus. The preliminary findings obtained from these investigations allowed the first analysis of the body size trend towards dwarfing in European Pleistocene Equus under a life history perspective. First results indicate that larger Middle Pleistocene equids grew at higher rates than smaller Late Pleistocene and extant species. This finding agrees with published paleoenvironmental reconstructions and conforms to life history models that propose resource availability as one of the main selection pressures influencing adult body size.

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Conceição, Maria da [UNESP]. "Aspectos histológicos e morfométricos da pele de cães do nascimento aos 70 dias de idade, clinicamente saudáveis." Universidade Estadual Paulista (UNESP), 2003. http://hdl.handle.net/11449/101321.

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Made available in DSpace on 2014-06-11T19:31:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2003Bitstream added on 2014-06-13T20:41:38Z : No. of bitstreams: 1 conceicao_m_dr_botfmvz.pdf: 3014470 bytes, checksum: 49d4919a2393deb79a1f34cf6e565343 (MD5) A pele exerce várias funções importantes, por isto várias conseqüências deletérias podem advir devido à sua imaturidade ou perda da sua integridade. O objetivo deste trabalho foi o de avaliar a evolução da pele dos cães recém-nascidos em relação à sua morfologia e celularidade desde o nascimento até 70 dias de idade, em 28 filhotes. As amostras de pele foram colhidas da região dorsal nos um, 20, 40 e 60 dias de vida, e da região ventral nos 10, 30, 50, e 70 dias de vida. As amostras obtidas por meio de biópsia da pele dos filhotes foram processadas e coradas pela hematoxilina-eosina, ácido periódico de Schiff, calleja sem permanganato de potássio, tricrômico de Masson e vermelho do congo-azul de toluidina acidificada. Comparando-se os resultados obtidos com os dados da literatura do cão adulto pôde-se verificar que os neonatos possuem os mesmos componentes da pele dos adultos. A espessura da membrana basal é linear tanto em machos quanto em fêmeas. Em relação ao sexo, houve diferença significativa da espessura das fibras colágenas da derme superficial e derme profunda, fibras elásticas e reticulares do dorso direito entre os machos e fêmeas de um, 20, 40 e 60 dias de vida. Nos filhotes machos as fibras tiveram espessamento linear. No que diz respeito à idade também houve diferença estatística da espessura das fibras colágenas da derme superficial e profunda e fibras elásticas. Nos filhotes machos há tendência de espessamento destas fibras com o amadurecimento dos animais. O local anatômico da colheita, dorso direito e ventre direito dos animais de 60 dias de idade, teve influência na espessura das fibras elásticas. As fibras do dorso direito dos filhotes machos são mais espessas do que as do ventre direito dos filhotes fêmeas. The skin exerts several important functions; therefore many deleterious consequences may occur due to its immaturity or loss of integrity. The scope of this study was to evaluate the evolution of skin from newborn dogs in its morphology and cellular content from birth until 70 days of age on 28 puppies. The skin samples were collected from the dorsal area at one, 20, 40 and 60 days of life; and from the ventral area at 10, 30, 50, 70 days of life. The samples were obtained through skin biopsy and stained by hematoxylineosin, Schiff periodic acid, calleja without potassium permanganate, trichromic of Masson, and modified congo red-acidified toluidine blue stain. Comparing the obtained results to literature data for adult dogs, it was verified that newborns posses the same skin components of adult dogs. The thickness of the basal membrane is linear for both males and females. Regarding sex, there was a significant difference of thickness on collagen fibers from superficial and deep dermis, as well as on elastic and reticular fibers from the right dorsum among males and females of one, 20, 40 and 60 days of life. On male puppies the fibers presented linear thickening. Concerning the age, there also was significant difference of thickness on collagen fibers from superficial and deep dermis and elastic fibers. On male puppies there is a tendency of thickening for those fibers, as the animals grow mature. The anatomic site for collecting – right dorsum and right ventral area of 60 day-old animals – had an influence on the thickness of elastic fibers. The fibers from the right dorsum of male puppies are thicker when comparing to those from the right ventral area of female puppies.

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Asaad, Kamil. "Comparative histology of human skin." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/5711.

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There are 5 distinct aspects to this study. (i) Two histological stains for collagen were compared against each other for the first time, namely Herovici's technique and picrosirius-polarization. (ii) Skin samples from embalmed cadaveric tissue from human cadavers were compared against samples taken from surgical patients. (iii) Skin samples were studied from different regions of the body to assess if dermal structure correlates with scarring potential. (iv) Skin samples were sectioned in a plane parallel to the epidermis to gain further insight into dermal structure. (v) A novel basement membrane stain was produced. Type I and type III collagen are important structural constituents of dermis and play a crucial role in wound healing. Only two traditional histological methods are thought to differentiate between them, so avoiding the need for antibodies. These were compared against each other for the first time in order to establish differences in image quality and discrimination between Type I and type III collagen. Neither technique requires antibodies, however picrosirius requires polarisation microscopy. to result in a clearer, consistently reproducible collagen staining pattern than the picrosirius method and more importantly did not require elaborate apparatus to analyze. Additionally other cellular elements were visible. Skin samples for research are often obtained from surgical excision. This clearly limits which tissues are available for comparative study to those areas operated on. Studying samples from embalmed medical school cadavers has the great advantage of studying areas of the body not routinely available from common surgical procedures. It was therefore desirable to assess whether embalmed cadaveric tissues exhibited different properties by virtue of their age and the embalming process compared to fresh surgical specimens, in order to give confidence that studies utilising the former would be equally valid. To test this, 58 skin samples from embalmed medical school cadavers were compared to skin samples from 38 fresh operative specimens. The levels of tissue preservation and processing artefacts were similar in both groups. Embalmed medical school cadavers clearly offer an opportunity to study tissue areas not routinely available during surgery. This is the first time such a comparison has been made. Many things will affect the final appearance of the scar, but the single most important determinant is the body region affected. The most common areas for unfavourable scarring, specifically keloid or hypertrophic scarring have been shown to be the ear, deltoid and sternal areas. To test the hypothesis that there is no difference in histological structure of skin that correlates to body region, comparative histology was undertaken exploring the regional variations of skin characteristics in 58 cadaveric samples. Closely comparable samples were taken from the deltoid (9), abdomen (13), sternum (10), post-auricular (5), earlobe (12) and eyelid (9). Epidermal thickness, epidermal appendage density and collagen fibre orientation were examined and qualitative structural differences were assessed for each region Skin samples were then grouped by both topographical location of the body and scarring potential. Skin samples exhibited qualitative and quantifiable regional variations in the characteristics studied. Epidermal thickness and appendage counts did not correlate with scarring potential. Both however were statistically significantly higher in skin sampled from the head compared to the trunk. Bundles of collagen fibres in the reticular dermis were grouped according to their orientation in relation to the coronal plane; either parallel, oblique or perpendicular. The ratio of oblique to parallel fibres was statistically significantly higher in body areas with poorer scarring prognosis. This corresponds to a more disorganised arrangement of collagen fibres in these areas. Further qualitative understanding of dermal collagen fibres came from perpendicular to conventional histological samples. This new method stained basement membranes purple, cytoplasm was stained greenish-brown and nuclei dark brown. Collagen fibres were either thin and blue or thick and green. This method was compared to PAS staining and although required more preparative steps allows greater identification of other cellular structures.

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Conceição, Maria da. "Aspectos histológicos e morfométricos da pele de cães do nascimento aos 70 dias de idade, clinicamente saudáveis /." Botucatu : [s.n.], 2003. http://hdl.handle.net/11449/101321.

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Orientador : Michiko Sakate Resumo: A pele exerce várias funções importantes, por isto várias conseqüências deletérias podem advir devido à sua imaturidade ou perda da sua integridade. O objetivo deste trabalho foi o de avaliar a evolução da pele dos cães recém-nascidos em relação à sua morfologia e celularidade desde o nascimento até 70 dias de idade, em 28 filhotes. As amostras de pele foram colhidas da região dorsal nos um, 20, 40 e 60 dias de vida, e da região ventral nos 10, 30, 50, e 70 dias de vida. As amostras obtidas por meio de biópsia da pele dos filhotes foram processadas e coradas pela hematoxilina-eosina, ácido periódico de Schiff, calleja sem permanganato de potássio, tricrômico de Masson e vermelho do congo-azul de toluidina acidificada. Comparando-se os resultados obtidos com os dados da literatura do cão adulto pôde-se verificar que os neonatos possuem os mesmos componentes da pele dos adultos. A espessura da membrana basal é linear tanto em machos quanto em fêmeas. Em relação ao sexo, houve diferença significativa da espessura das fibras colágenas da derme superficial e derme profunda, fibras elásticas e reticulares do dorso direito entre os machos e fêmeas de um, 20, 40 e 60 dias de vida. Nos filhotes machos as fibras tiveram espessamento linear. No que diz respeito à idade também houve diferença estatística da espessura das fibras colágenas da derme superficial e profunda e fibras elásticas. Nos filhotes machos há tendência de espessamento destas fibras com o amadurecimento dos animais. O local anatômico da colheita, dorso direito e ventre direito dos animais de 60 dias de idade, teve influência na espessura das fibras elásticas. As fibras do dorso direito dos filhotes machos são mais espessas do que as do ventre direito dos filhotes fêmeas. Abstract: The skin exerts several important functions; therefore many deleterious consequences may occur due to its immaturity or loss of integrity. The scope of this study was to evaluate the evolution of skin from newborn dogs in its morphology and cellular content from birth until 70 days of age on 28 puppies. The skin samples were collected from the dorsal area at one, 20, 40 and 60 days of life; and from the ventral area at 10, 30, 50, 70 days of life. The samples were obtained through skin biopsy and stained by hematoxylineosin, Schiff periodic acid, calleja without potassium permanganate, trichromic of Masson, and modified congo red-acidified toluidine blue stain. Comparing the obtained results to literature data for adult dogs, it was verified that newborns posses the same skin components of adult dogs. The thickness of the basal membrane is linear for both males and females. Regarding sex, there was a significant difference of thickness on collagen fibers from superficial and deep dermis, as well as on elastic and reticular fibers from the right dorsum among males and females of one, 20, 40 and 60 days of life. On male puppies the fibers presented linear thickening. Concerning the age, there also was significant difference of thickness on collagen fibers from superficial and deep dermis and elastic fibers. On male puppies there is a tendency of thickening for those fibers, as the animals grow mature. The anatomic site for collecting - right dorsum and right ventral area of 60 day-old animals - had an influence on the thickness of elastic fibers. The fibers from the right dorsum of male puppies are thicker when comparing to those from the right ventral area of female puppies. Doutor

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Diagone, Karen Vicente. "Histologia e morfometria dos testículos de gatos domésticos adultos /." Jaboticabal :, 2009. http://hdl.handle.net/11449/101120.

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Resumo: Neste trabalho foram analisados histológica e morfometricamente testículos de 30 gatos distribuídos em três grupos (G) com idades reprodutivas diferentes, G1 (um a dois anos), G2 (maiores de dois a quatro anos) e G3 (maiores de quatro a seis anos), sem raça definida, e desprovidos de doenças reprodutivas. Após a orquiectomia, a gônada direita foi lavada em água corrente e fixada em solução Bouin durante 24 horas e processada rotineiramente para a inclusão em parafina. Foram realizados cortes semiseriados de 120 micrômetros (μm) com espessura de cinco micrômetros, corados pela Hematoxilina Eosina e fotomicrografados no aparelho Olympus Bx 50 CCD®. Os parâmetros morfométricos estudados a partir do sistema analisador de imagens (Image Pro-plus) foram as espessuras da camada albugínea (72 μm) e do epitélio seminífero (77,19 μm), perímetro (53,81; 90,57 μm) e (54,80; 101,07 μm), área (174,23; 494,55 μm2) e (176,68; 629,70 μm2), diâmetros máximo (14,94; 28,02 μm) e (14,76; 31,66 μm) e mínimo (13,25; 21,92 μm) e (13,30; 24,52 μm) e fator de forma (1,36; 1,36) e (1,39; 1,35) do núcleo e citoplasma das espermatogônias e células de Leydig respectivamente. O procedimento estatístico utilizado foi a ANOVA. Estes resultados podem ser utilizados em estudos comparativos com outros felinos, e contribuir com profissionais da área em relação a altura do epitélio seminífero e espessura da túnica albugínea e tamanho das espermatogônias e células de Leydig Abstract: It was carried out in this research histological and morphometric analyses of testes of 30 mixed breed cats distributed in three groups (G) according to their ages, G1 (1 to 2 years), G2 (> 2 to 4 years) and G3 (> 4 to 6 years) , without reproductive diseases. After the performance of the orchiectomy, the right testis of each animal was washed under running water for removal of blood excess, fixed in Bouin solution for 24 hours, submitted to routine histological processing. The blocks of all samples were cut into 5-μm thick sections and the testes were cut into five 120-μm semi-serial sections. The specimens were mounted on glass slides, stained with hematoxylin-eosin technique and the histological sections were examined and photographed under an Olympus BX50 photomicroscope. The following morphometric parameters were analyzed: thickness of the tunica albuginea (72 μm) and seminiferous epithelium (77,19 μm) of the seminiferous tubules. Nucleus and cytoplasm of type A spermatogonia and Leydig cells were also studied: perimeter (53,81; 90,57 μm) and (54,80; 101,07 μm), area (174,23; 494,55 μm2) and (176,68; 629,70 μm2), maximum diameter (14,94; 28,02 μm) and (14,76; 31,66 μm), minimum diameter (13,25; 21,92 μm) and (13,30; 24,52 μm) and roundness factor (1,36; 1,36) and (1,39; 1,35) respectively. All analyses were performed using ANOVA. These parameters could be used in comparative studies with another feline species, to improve information about the thickness of the seminiferous epithelium, tunica propria, spermatogonia and Leydig cells to help feline reproduction professionals Orientador: Wilter Ricardo Russiano Vicente Coorientador: Maria Rita Pacheco Banca: Ana Paula Coelho Ribeiro Banca: Frederico Ozanam Barros Monteiro Banca: Paulo Henrique Franceschini Banca: Marion Burkhardt de Koivisto Doutor

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Bori, i. Tuneu Guillem. "Utilitat de la histologia en el diagnòstic de la infecció de l’artroplàstia de maluc." Doctoral thesis, Universitat de Barcelona, 2010. http://hdl.handle.net/10803/31996.

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Aquesta tesi està dedicada a l’estudi de la utilitat del nombre de leucòcitspolimorfonuclears en els teixits periprotètics pel diagnòstic de la infecció, a determinarquin es el punt de tall per definir infecció i a estudiar quina relació hi ha entre el númerode leucòcits polimorfonuclears trobats en les membranes periprotètiques i elmicroorganisme aïllat en els cultius convencionals.El primer objectiu avalua la utilitat de la histologia segons el criteri de Mirra iadaptat per Feldman (≥5 leucòcits polimorfonuclears per camp de gran augment) en tressituacions; recanvi protètic per sospita d’afluixament asèptic, per sospita d’afluixamentsèptic o reimplantació d’una pròtesi després d’un primer temps sèptic. En el cas delrecanvi per afluixament asèptic i en el moment de la reimplantació d’una pròtesi desprésd’un primer temps sèptic, la histologia presenta una sensibilitat baixa per tald’identificar una infecció. En canvi en el cas d’un recanvi amb la sospita d’afluixamentsèptic, la histologia es mostra com un test vàlid, ja que en la majoria de les situacionsconfirma aquesta sospita preoperatòria.El segon objectiu estudia si un punt de tall més baix (≥1 leucòcitspolimorfonuclears per camp de gran augment) és més eficaç en el diagnòstic de lainfecció. El resultat demostra que aquesta modificació fa que la histologia sigui méssensible però comporta un descens de l’especificitat.El tercer objectiu analitza la relació entre el número de leucòcitspolimorfonuclears i el tipus de microorganisme aïllat. L’aïllament d’estafilococscoagulasa-negativa es va associar a una menor infiltració de leucòcits polimorfonuclearsen els teixits periprotètics que amb altres microorganismes com Staphylococcus aureuso Bacils Gram-negatius com Escherichia coli o Pseudomonas spp.

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McCann, Michael T. "Tools for Automated Histology Image Analysis." Research Showcase @ CMU, 2015. http://repository.cmu.edu/dissertations/678.

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In this thesis, we present three image processing tools inspired by and designed for histology image analysis. Histology, which is the examination of biological tissue under a microscope, is a critical technique in biomedical research and clinical practice. While slide preparation and imaging is increasingly becoming automated, the analysis of the resulting histology images is not: even routine analyses still require the trained eyes of a pathologist. In our work, we aim to understand histology images as a class of signals and develop tools to aid in the automated analysis of these signals. Our first contribution is in the area of histology image normalization, where the goal is to digitally remove the variation in staining between histology images, an important preprocessing step in many histology image analysis systems. To this end, we created a new benchmark dataset with which to compare normalization methods and proposed our own. Our second contribution is a tissue segmentation method, which delineates single-tissue regions in histology images. Along with this method, we propose a new mathematical model for histology images. Our final contribution is a method for describing distributions of angles, which is useful for segmentation as well as a variety of other image processing tasks.

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Butterworth, Rosalind J. "The histology of human granulating wounds." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/34293.

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1. The prime aim of this study was to investigate the structure and cellularity of human granulation tissue, by the taking of punch biopsies from clinical wounds, a method not previously reported in wound research. It was intended both to further the understanding of wound biology, and to provide baseline information for clinical trials of therapeutic agents, such as dressing materials and growth factors. 2. To evaluate the validity of the universally used animal models of wound healing, and the extent to which data from them can be extrapolated to the human wound. 3. To relate histological criteria to the progress of wound healing as observed clinically, in both normally healing and unhealthy wounds. This might allow diagnosis of difficult healing problems to be made by biopsy, and also has relevance to wound biology in providing circumstantial evidence of cell function. 4. To compare conventional and immunocytochemical staining techniques in identification of cell types in human granulation tissue. 5. As a particular area of interest, to clarify the role of the myofibroblast in wound contraction by identification of a suitable marker for this cell in human granulation tissue, and by examining the temporal relationship between myofibroblast presence and wound contraction.

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Miszkiewicz, Justyna J. "Ancient human bone histology and behaviour." Thesis, University of Kent, 2014. https://kar.kent.ac.uk/38319/.

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Chedid, Renata Alari [UNESP]. "Estudo morfológico e histoquímico do tubo digestivo de eleuteroembriões e larvas de Leporinus obtusidens (Valenciennes, 1836)." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/86661.

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Made available in DSpace on 2014-06-11T19:22:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-01-27Bitstream added on 2014-06-13T18:08:08Z : No. of bitstreams: 1 chedid_ra_me_jabo.pdf: 1366238 bytes, checksum: 21a6e3e47bfbdb87f49b7e199bfd5d21 (MD5) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Leporinus obtusidens apresenta características zootécnicas interessantes e promissoras para o cultivo em piscicultura. Na maioria das espécies cultivadas, as larvas, ao iniciarem a alimentação exógena, são organismos cujo desenvolvimento ainda não se completou, razão pela qual os órgãos digestivos não estão totalmente definidos e o conteúdo enzimático ainda é deficiente. As pesquisas com larvas de peixes apontam para a alimentação como o fator de maior importância a ser considerado durante o desenvolvimento inicial, pois os organismos estão na fase de diferenciação estrutural e funcional do sistema digestório. Assim o objetivo deste trabalho foi analisar as características histológicas e histoquímicas do tudo digestivo de Leporinus obtusidens nas fases iniciais do desenvolvimento. As amostras foram fixadas em solução de Karnovsky e processadas para análises histológicas e histoquímicas. A eclosão dos eleuteroembriões de L. obtusidens ocorreu às 15 horas após a fertilização (28°C) e as reservas de vitelo foram observadas até 120 horas após a eclosão (HAE). A boca sofreu modificações na posição, passando de ventral para subterminal. Com relação ao esôfago, foi possível observar as primeiras células caliciformes com 48 HAE e a partir de 64 HAE intensa positividade ao PAS e ao AB. A partir de 30 HAE foi possível observar o primórdio do estômago, caracterizado pela substituição do epitélio esofágico estratificado por epitélio gástrico simples, com presença de poucas células caliciformes. Com 96 HAE foi observada intensa reação ao PAS no epitélio de revestimento do estômago, o que indica funcionalidade do órgão. Quanto ao intestino, foi observado um desenvolvimento lento, as primeiras células caliciformes foram observadas com 96 HAE. Os cecos pilóricos foram evidenciados... Leporinus obtusidens husbandry has characteristics very interesting and promising for cultivation in aquaculture programs. Most of the cultivated species, the larvae begin to feed exogenously, are organisms whose metamorphosis is not complete, which is why the digestive organs are not fully defined and the enzyme content is still deficient. The studies with fish larvae feeding point to as the most important factor to be considered during early development, because the organisms are in the process of structural and functional differentiation of the digestive system. Thus the objective of this study was to analyze the histological and histochemical features of digestive L. obtusidens in all stages of development. Samples were collected in the Hydrobiology and Aquaculture Station of Companhia Energetica de São Paulo (CESP) Jupiá, SP. The samples were fixed in Karnovsky solution, processed for histological and immunohistochemical analysis. The outbreak of eleuteroembryo L. obtusidens occurred approximately 15 hours after fertilization (28 ° C) and the yolk reserves were observed up to 120 HAE. The mouth has undergone successive changes during development, the ventral position to the subterminal position. With regard to the esophagus, it was possible to observe the first goblet cells with 48 HAE and and starting at 64 HAE intense positivity to PAS and AB. From 30 HAE was possible to observe the beginnings of the stomach, characterized only by the substitution of an esophageal epithelium stratified by gastric epithelium simple with cuboidal cells, with little presence of goblet cells. Was observed with 96 HAE intense reaction to PAS in the epithelium lining of the stomach, indicating functionality of the organ. As the intestine, we observed a slow development, the first goblet cells were observed... (Complete abstract click electronic access below)

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Libri sul tema "Histology"

Jose, Carneiro, and Electronic Book Collection, eds. Basic histology: Text & atlas. New York: McGraw-Hill, Medical Pub. Division, 2005.

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Telford, Ira Rockwood. Introduction to functional histology. 2nd ed. Grand Rapids: HarperCollins, 1995.

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Fawcett, Don Wayne. A textbook of histology. New York: Chapman & Hall, 1994.

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Fawcett, Don Wayne. Bloom & Fawcett: Concise histology. New York: Chapman and Hall, 1997.

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Fawcett, Don Wayne. A textbook of histology. Philadelphia: Saunders, 1986.

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Feeback, Daniel L. Histology. New York, NY: Springer New York, 1987. http://dx.doi.org/10.1007/978-1-4612-4630-5.

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Bergman, Ronald A. Histology. Philadelphia: Saunders, 1996.

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I, Kaye Gordon, and Mazurkiewicz Joseph E, eds. Histology. Baltimore: Williams & Wilkins, 1997.

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Henrikson, Ray C. Histology. Baltimore: Williams & Wilkins, 1997.

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Stevens, Alan. Histology. London: Gower Medical Publishing, 1992.

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Capitoli di libri sul tema "Histology"

Slaney, Geoffrey, Jean Powell, Christopher C. Mcconkey, John A. H. Waterhouse, and Ciaran B. J. Woodman. "Histology." In Cancer of the Large Bowel, 60–81. London: Macmillan Education UK, 1991. http://dx.doi.org/10.1007/978-1-349-11420-7_3.

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Fielding, John W. L., Jean Powell, William H. Allum, John A. H. Waterhouse, and Christopher C. McConkey. "Histology." In Cancer of the Stomach, 42–53. London: Macmillan Education UK, 1989. http://dx.doi.org/10.1007/978-1-349-10415-4_3.

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Robin, Peter E., Jean Powell, Guy M. Holme, John A. H. Waterhouse, Christopher C. McConkey, and Janet E. Robertson. "Histology." In Cancer of the Larynx, 42–60. London: Palgrave Macmillan UK, 1989. http://dx.doi.org/10.1007/978-1-349-10418-5_4.

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Matthews, Hugoe R., John A. H. Waterhouse, Jean Powell, Janet E. Robertson, and Christopher C. McConkey. "Histology." In Cancer of the Oesophagus, 40–58. London: Palgrave Macmillan UK, 1987. http://dx.doi.org/10.1007/978-1-349-09074-7_3.

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Hellquist, Henrik, and Alena Skalova. "Histology." In Histopathology of the Salivary Glands, 1–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-540-46915-5_1.

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Dirnhofer, Stefan. "Histology." In Myelodysplastic Syndromes, 39–41. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-76879-3_3.

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Kendall, Marion D. "Histology." In Surgery of the Thymus, 27–38. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-71076-6_4.

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Gross, Gerd, and Stefania Jablonska. "Histology." In Human Papillomavirus Infections in Dermatovenereology, 251–58. Boca Raton: CRC Press, 2024. http://dx.doi.org/10.1201/9781003575061-22.

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Datta, Subodh Kumar. "Histology." In Induced Mutation Breeding, 123–24. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-9489-0_10.

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Gudo, Michael, Gerta Fleissner, and Guenther Fleissner. "Histology." In Encyclopedia of Geobiology, 441–47. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-1-4020-9212-1_110.

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Atti di convegni sul tema "Histology"

Molina-Navarro, María Micaela, Sergio Cutillas, Miriam García, Rafaela Domínguez, Raul Ballestín, Anna García-Forner, Natalia Conejero-Ortega, et al. "A VIRTUAL MICROSCOPE REVOLUTIONIZING HISTOLOGY LESSONS." In 17th annual International Conference of Education, Research and Innovation, 10041–45. IATED, 2024. https://doi.org/10.21125/iceri.2024.2526.

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Marini, M., M. Bouzin, L. Sironi, L. Presotto, J. Riccio, D. Panzeri, D. Inverso, M. Collini, L. D’Alfonso, and G. Chirico. "Unlocking Tissue Secrets: Live Histology without Labels Through Microtructured Imaging Windows." In Frontiers in Optics, FM1B.2. Washington, D.C.: Optica Publishing Group, 2024. https://doi.org/10.1364/fio.2024.fm1b.2.

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Ex-vivo histology is time consuming, subjective, and invasive. We discuss how, by coupling non-linear excitation and structured illumination to physically inspired image reconstruction and micro-structuring optical windows, we can obtain in-vivo tissue histology.

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Maleki, Danial, Nazim Shaikh, Gareth Shannon, Jian Li, and Yao Nie. "Multimodal pretraining for histology-gene joint representation learning." In Digital and Computational Pathology, edited by John E. Tomaszewski and Aaron D. Ward, 31. SPIE, 2025. https://doi.org/10.1117/12.3047357.

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Lu, Eric Y., Maryse Lapierre-Landry, Made Airanthi K. Widjaja-Adhi, Matthew T. McPheeters, Andrew M. Rollins, Marcin Golczak, and Michael W. Jenkins. "3D multiplexed virtual histology in the ocular system." In Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXXII, edited by Thomas G. Brown, Tony Wilson, and Laura Waller, 8. SPIE, 2025. https://doi.org/10.1117/12.3043599.

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Vázquez-Flores, Jorge, Rodrigo Pantoja-Vázquez, Víctor Menéndez-Domínguez, and Héctor Rubio-Zapata. "EXPLORING HISTOLOK AS A GAMIFIED LEARNING TOOL IN MEDICAL HISTOLOGY." In 18th International Technology, Education and Development Conference. IATED, 2024. http://dx.doi.org/10.21125/inted.2024.0596.

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Jafari, Nooshin, and Artur Chodorowski. "Histology-based oral lesion classification." In 2012 20th Iranian Conference on Electrical Engineering (ICEE). IEEE, 2012. http://dx.doi.org/10.1109/iraniancee.2012.6292619.

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Shojaii, Rushin, Tigran Karavardanyan, Martin Yaffe, and Anne L. Martel. "Validation of histology image registration." In SPIE Medical Imaging, edited by Benoit M. Dawant and David R. Haynor. SPIE, 2011. http://dx.doi.org/10.1117/12.878762.

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Rahmadwati, Golshah Naghdy, Montse Ross, Catherine Todd, and Eviana Norachmawati. "Classification Cervical Cancer Using Histology Images." In 2010 Second International Conference on Computer Engineering and Applications. IEEE, 2010. http://dx.doi.org/10.1109/iccea.2010.105.

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Claridge, E., and SD Cotton. "Imaging skin histology through parametric mapping." In Biomedical Topical Meeting. Washington, D.C.: OSA, 2004. http://dx.doi.org/10.1364/bio.2004.wf21.

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Reinisch, Lou, and C. Gaelyn Garrett. "Image analysis of vocal fold histology." In BiOS 2001 The International Symposium on Biomedical Optics, edited by R. Rox Anderson, Kenneth E. Bartels, Lawrence S. Bass, C. Gaelyn Garrett, Kenton W. Gregory, Abraham Katzir, Nikiforos Kollias, et al. SPIE, 2001. http://dx.doi.org/10.1117/12.427821.

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Rapporti di organizzazioni sul tema "Histology"

Joye, Gary F., and Rex Paul. Histology of Infection of Hydrilla verticillata by Macrophomina phaseolina. Fort Belvoir, VA: Defense Technical Information Center, October 1991. http://dx.doi.org/10.21236/ada242194.

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Urumov, Zaurnek Elbrusovich, Albina Iradionovna Tshovrebova, and Zalina Kolumbovna Malieva. Methods of increasing the quality of learning histology at the university. DOI СODE, 2021. http://dx.doi.org/10.18411/doicode-2022.042.

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Pellmar, Terry C. Health Risk Assessment of Embedded Depleted Uranium: Behavior, Physiology, Histology and Biokenetic Modeling. Fort Belvoir, VA: Defense Technical Information Center, October 1997. http://dx.doi.org/10.21236/adb236551.

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Oliveira, Marcelo B. d. R., Francesca B. Ramundo, Pedro D. C. S. Silva, Bruno S. Queiroz, Ana C. C. C. Caetano, César R. d. C. Fontenelle, Daniel Umpierre, and Fernanda C. d. Q. Mello. Association of Lung Cancer Histology with Developing Bone Metastasis: A Systematic Review Protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2024. http://dx.doi.org/10.37766/inplasy2024.9.0007.

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Lammers, Peter J., Kristjan Bregendahl, Steven M. Lonergan, Dong U. Ahn, Mark S. Honeyman, Kenneth J. Prusa, Brian J. Kerr, Thomas E. Webber, and William C. Stoffregen. Carcass Characteristics, Meat Quality, and Tissue Histology of Growing Pigs Fed Crude Glycerol-Supplemented Diets. Ames (Iowa): Iowa State University, January 2008. http://dx.doi.org/10.31274/ans_air-180814-1054.

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Wilhelms, Kelly W., Katie F. Fitzpatrick, Colin G. Scanes, and Lloyd L. Anderson. In Ovo Exposure to Atrazine on Circulating Reproductive Hormones and Gonadal Histology in Japanese Quail. Ames (Iowa): Iowa State University, January 2010. http://dx.doi.org/10.31274/ans_air-180814-761.

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ปริยานนท์, ผุสตี, กัมพล อิศรางกูร ณ อยุธยา, นงเยาว์ จันทร์ผ่อง, ธีรวรรณ นุตประพันธุ์, อารมณ์ รัศมิทัต, กิ่งแก้ว วัฒนเสริมกิจ, วีณา เมฆวิชัย та วิโรจน์ ดาวฤกษ์. การศึกษาชีววิทยาของกบภูเขา (เขียดแลว) เพื่อเป็นแนวทางในการอนุรักษ์พันธุ์. จุฬาลงกรณ์์มหาวิทยาลัย, 1986. https://doi.org/10.58837/chula.res.1986.12.

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การศึกษาลักษณะนิเวศน์ของกบภูเขา พบว่าปัจจัยที่สำคัญที่สุดในการดำรงชีวิต คือ สภาพแหล่งที่อยู่อาศัย กบจะอาศัยในลำธารที่มีน้ำไหลและในสภาพแวดล้อมที่มีความชื้นสูง อุณหภูมิไม่เป็นปัจจัยที่สำคัญ กบจะวางไข่ได้เกือบตลอดปี ขึ้นอยู่กับปริมาณน้ำ สภาพกรวดและหินบริเวณพื้นน้ำที่รองรับหลุมไข่ กบภูเขาจะวางไข่ในหลุมที่มีเส้นผ่าศูนย์กลางประมาณ 45-70 ซม. ลึก 4-10 ซม. กบภูเขาที่มีขนาดโตเต็มที่ ตัวผู้จะมีขนาดใหญ่กว่าตัวเมีย มีเขี้ยว 2 อันที่ริมฝีปากล่าง ซึ่งยาวกว่าของตัวเมีย ผิวหนังจะมีลักษณะเรียบและลื่นคล้ายผิวหนังเขียด มีสีน้ำตาลปนเขียว ขาหลังจะมีขนาดใหญ่กว่าขาหน้ามากเมื่อเปรียบเทียบกับกบนา ทางเดินอาหารสั้น ไม่พบไขมันสะสมหรือถ้าพบก็มีขนาดเล็กมาก ซึ่งเชื่อว่าน่าจะไม่มีการสะสมอาหารเพื่อการจำศีล การศึกษาทางปาราสิตพบพยาธิใบไม้ 5 สกุล พยาธิตัวกลม 4 สกุล โปรโตซัว 6 สกุล และพยาธิหนอนหัวหนามไฟลั่ม Acanthocephalan 1 ตัว ไม่ทราบชื่อวิทยาศาสตร์ อวัยวะที่พบปาราสิตมากที่สุดได้แก่ ลำไส้ใหญ่ ลำใส้เล็ก ใต้เยื่อบุช่องท้อง ตับและไตตามลำดับ การศึกษาชีววิทยาการสืบพันธุ์โดยใช้ฮอร์โมนในการชักนำเพื่อทำให้เกิดการตกไข่ และการหลั่งอสุจิ พบว่าการใช้ต่อมใต้สมองของกบนาจำนวน 5 และ 7 ต่อม ฉีดเข้าช่องท้องของกบภูเขาตัวเมียยังไม่สามารถชักนำให้เกิดการตกไข่ รวมทั้งการใช้ฮอร์โมน HCG 150 IU ฉีดเข้ากบตัวผู้ก็ยังไม่สามารถทำให้กบตัวผู้หลั่งอสุจิได้ และจากผลการศึกษาทาง Histology ของอวัยวะสืบพันธุ์พบว่าในกบภูเขาที่ทำการทดลอง และกลุ่มควบคุม ไม่มีความแตกต่างกันอย่างมีนัยสำคัญที่ p>0.05

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Leelahavanichkul, Asada. Helicobacter pylori infection increased anti-dsDNA and enhanced lupus severity in symptomatic FcγRIIb-deficient lupus mice. Chulalongkorn University, 2019. https://doi.org/10.58837/chula.res.2019.10.

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Abstract (sommario):

The defect on Fc gamma receptor IIb (FcyRIIb), the only inhibitory FcyR, has been identified as one of the genetic factors increasing susceptibility to lupus. The prevalence of Helicobacter pylori (HP) and FcyRIIb dysfunction-polymorphisms are high among Asians, and their co-existence is possible. Unfortunately, the influence of HP against lupus progression in patients with lupus is still controversial. In this study, the interactions between these conditions were tested with HP infection in 24-week-old Fc yRIIb−/− mice (symptomatic lupus). HP induced failure to thrive, increased stomach bacterial burdens and stomach injury (histology and cytokines) in both wild type and FcyRIIb−/− mice. While the severity of HP infection, as determined by these parameters, was not different between both strains, antibodies production (anti-HP, anti-dsDNA and serum gammaglobulin) were higher in FcyRIIb−/− mice compared to wild type. Accordingly, HP infection also accelerated the severity of lupus as determined by proteinuria, serum creatinine, serum cytokines, renal histology, and renal immune complex deposition. Although HP increased serum cytokines in both wild type and FcyRIIb−/− mice, the levels were higher in FcyRIIb−/− mice. As such, HP also increased spleen weight and induced several splenic immune cells responsible for antibody productions (activated B cell, plasma cell and follicular helper T cell) in FcyRIIb−/− mice, but not in wild type. These data describe the different systemic responses against localized HP infection from diverse host genetic background. In conclusion, the mutual interactions between HP and lupus manifestations of FcyRIIb−/−mice were demonstrated in this study. With the prominent immune responses from the loss of inhibitory signaling in FcyRIIb−/− mice, HP infection in these mice induced intense chronic inflammation, increased antibody production, and enhanced lupus severity. Thus, the increased systemic inflammatory responses due to localized HP inducing gastritis in some patients with lupus may enhance lupus progression. More studies are needed.

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Freedman, Matthew T. Electrical Impedance Imaging of the Breast: Correlation with MRI, US, Sestamibi, and Histology With Measures of Cell Proliferation and Vascular Density. Fort Belvoir, VA: Defense Technical Information Center, September 2001. http://dx.doi.org/10.21236/ada396869.

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Freedman, Matthew. Electrical Impedance Imaging of the Breast: Correlation With MRI, US, Sestamibi and Histology With Measures of Cell Proliferaton and Vascular Density. Fort Belvoir, VA: Defense Technical Information Center, September 2002. http://dx.doi.org/10.21236/ada410879.

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