Bibliografie tematiche / High grade prostatic intraepithelial neoplasia

Letteratura scientifica selezionata sul tema "High grade prostatic intraepithelial neoplasia"

Autore: Grafiati
Pubblicato: 4 giugno 2021
Ultima modifica: 1 febbraio 2022

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Articoli di riviste sul tema "High grade prostatic intraepithelial neoplasia"

1

Bostwick, David G., e Junqi Qian. "High-grade prostatic intraepithelial neoplasia". Modern Pathology 17, n. 3 (23 gennaio 2004): 360–79. http://dx.doi.org/10.1038/modpathol.3800053.

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Klink, Joseph C., Ranko Miocinovic, Cristina Magi Galluzzi e Eric A. Klein. "High-Grade Prostatic Intraepithelial Neoplasia". Korean Journal of Urology 53, n. 5 (2012): 297. http://dx.doi.org/10.4111/kju.2012.53.5.297.

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Weiss, Mark A. "High-Grade Prostatic Intraepithelial Neoplasia". Archives of Pathology & Laboratory Medicine 125, n. 3 (1 marzo 2001): 440–42. http://dx.doi.org/10.5858/2001-125-0440-hgpin.

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4

Xiao, Guang-Qian, e Pamela D. Unger. "Focal Signet Ring Cell High-Grade Prostatic Intraepithelial Neoplasia on Needle Biopsy". International Journal of Surgical Pathology 25, n. 4 (6 gennaio 2017): 344–47. http://dx.doi.org/10.1177/1066896916685835.

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Signet ring cell prostatic intraepithelial neoplasia is a rare speculated variant of high-grade prostatic intraepithelial neoplasia (HGPIN). Here, we present a free-standing and isolated signet ring cell HGPIN that was not associated with invasive carcinoma on needle biopsy and demonstrated the existence of this type of HGPIN variant. The differentiation between HGPIN and intraductal carcinoma of prostate is also discussed.
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Sakr, W. A., D. J. Grignon, G. P. Haas, K. L. Schomer, L. K. Heilbrun, B. J. Cassin, I. J. Powell, J. A. Montie, J. E. Pontes e J. D. Crissman. "Epidemology of High Grade Prostatic Intraepithelial Neoplasia". Pathology - Research and Practice 191, n. 9 (settembre 1995): 838–41. http://dx.doi.org/10.1016/s0344-0338(11)80965-9.

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Waters, David J. "High-Grade Prostatic Intraepithelial Neoplasia in Dogs". European Urology 35, n. 5-6 (1999): 456–58. http://dx.doi.org/10.1159/000019878.

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Berman, David M., Jiming Yang e Jonathan I. Epstein. "Foamy Gland High-Grade Prostatic Intraepithelial Neoplasia". American Journal of Surgical Pathology 24, n. 1 (gennaio 2000): 140. http://dx.doi.org/10.1097/00000478-200001000-00018.

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Wael Sakr, A., Athanase Billis, Peter Ekman, Timothy Wilt e David G. Bostwick. "Epidemiology of High-Grade Prostatic Intraepithelial Neoplasia". Scandinavian Journal of Urology and Nephrology 34, n. 205 (gennaio 2000): 11–18. http://dx.doi.org/10.1080/003655900750169275.

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Allen, Elizabeth A., David A. Brinker, Domenico Coppola, Jose I. Diaz e Jonathan I. Epstein. "Multilocular prostatic cystadenoma with high-grade prostatic intraepithelial neoplasia". Urology 61, n. 3 (marzo 2003): 644. http://dx.doi.org/10.1016/s0090-4295(02)02274-4.

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Billis, Athanase, e Luis A. Magna. "Inflammatory Atrophy of the Prostate". Archives of Pathology & Laboratory Medicine 127, n. 7 (1 luglio 2003): 840–44. http://dx.doi.org/10.5858/2003-127-840-iaotp.

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Abstract Context.—Recently, prostatic atrophy associated with chronic inflammation has been linked to carcinoma either directly or indirectly by first developing into high-grade prostatic intraepithelial neoplasia. Objective.—The purpose of our study was to test this hypothesis in autopsies. Design.—A step section method was used to cut the posterior lobe in coronal planes at intervals of 0.3 to 0.5 cm in 100 consecutive autopsies of men older than 40 years. Prostatic atrophy was classified as simple, hyperplastic (or postatrophic hyperplasia), and sclerotic and was analyzed for the presence of chronic inflammation. Prostatic atrophy without (group A) and with inflammation (group B) was correlated with the following variables: age, race, histologic (incidental) carcinoma, high-grade prostatic intraepithelial neoplasia, and extent of both these lesions. Results.—Of the 100 prostates examined, 12%, 22% and 66%, respectively, had no atrophy, atrophy without inflammation (group A), and atrophy with inflammation (group B). There was no statistically significant difference between groups A and B for age (P = .55), race (P = .89), presence of histologic (incidental) carcinoma (P = .89), extensive carcinoma (P = .43), presence of high-grade prostatic intraepithelial neoplasia (P = .65), extensive high-grade intraepithelial neoplasia (P = .30), or subtypes of prostatic atrophy. Neither a topographical relation nor a morphologic transition was seen between prostatic atrophy and histologic carcinoma or high-grade intraepithelial neoplasia. Sclerotic atrophy either alone or combined with other subtypes was more frequent in the group with inflammation. A striking morphologic finding was a topographical relation of focal inflammation with sclerotic atrophy in areas with erosion of the epithelium. Conclusions.—Inflammatory prostatic atrophy does not appear to be associated with histologic (incidental) carcinoma or high-grade intraepithelial neoplasia. One possible cause of inflammatory infiltrate associated with prostatic atrophy may be the extravasated prostatic secretions, which were noted in areas of eroded epithelium, a common finding in the sclerotic type of prostatic atrophy.
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Più fonti

Tesi sul tema "High grade prostatic intraepithelial neoplasia"

1

Al-Maghrabi, Jaudah. "Genomic alterations in prostate high-grade intraepithelial neoplasia (HPIN) can be predictive of a more aggressive disease process". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58691.pdf.

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Rasiah, Krishan Kumar St Vincent's UNSW. "The identification of novel biomarkers in the development and progression of early prostate cancer". Awarded by:University of New South Wales. St Vincent's, 2006. http://handle.unsw.edu.au/1959.4/24187.

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ABSTRACT The morphological premalignant changes in prostate epithelium such as high grade prostatic intraepithelial neoplasia (HGPIN) precede invasive prostate cancer (PC) by several decades. The overall aim of this project was to identify patterns of gene expression in HGPIN and early PC which increase our understanding of the early biology of PC and identify genes and pathways that correlate with an aggressive phenotype. A comprehensive tissue cohort of premalignant prostate lesions was collected in a tissue microarray (TMA) platform that was utilised for high-throughput validation of target genes. Using this unique resource, the expression of the tumour suppressor gene PTEN was assessed using immunohistochemistry in an initial candidate gene approach based on mouse models implicating PTEN in carcinogenesis. No significant difference in expression of PTEN was detected in premalignant and benign epithelium. A transcript profiling approach was undertaken by integrating laser capture microdissection, linear RNA amplification and oligonucleotide microarrays to perform a screen of matched patient samples of normal, HGPIN and PC cells. The expression patterns of two genes encoding secreted proteins, neuropeptide Y (NPY) and macrophage inhibitory cytokine (MIC-1) were validated using immunohistochemistry on TMAs representing the progression model of early PC. Increased expression of these proteins in PC was confirmed to occur early in the disease process and altered expression of NPY and MIC-1 was associated with worse clinical outcome. Further analysis of global gene expression patterns using a structured network knowledge base identified a notable aberration in the expression of extracellular matrix and extracellular matrix associated proteins in HGPIN and provided novel evidence for the role of this class of molecules in the development of PC. In summary, contrary to current dogma based on work in animal models, altered PTEN expression is unlikely to represent an important event in the development of malignancy in the human prostate. In contrast, the expression patterns and prognostic value of NPY and MIC-1 in HGPIN support their further evaluation as biomarkers for the development and progression of PC. The aberrant expression of genes and networks of genes detected in HGPIN will assist in further identification of biological pathways which may be targeted in therapeutic strategies against the development and progression of PC.
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Auškalnis, Stasys. "Prostatos vėžio chemoprevencija dutasteridu esant didelei susirgimo rizikai". Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100913_131214-61635.

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Aukšto laipsnio prostatos intraepitelinė neoplazija (ALPIN, angl. – HGPIN – high grade prostatic intraepithelial neoplasia ) priskiriama prie priešvėžinių būklių ( arba prostatos vėžio prekursorių) ir susijusi su padidėjusia kartu esamo vėžio diagnozavimo rizika arba vėlesne jos progresija iki vėžio. Manoma, kad pacientai, kuriems nustatyta ALPIN prostatos biopsinėje medžiagoje, yra tinkami kandidatai chemoprevencijai. Šio darbo tikslas buvo nustatyti 5-alfa reduktazės inhibitoriaus dutasterido reikšmę prostatos vėžio prevencijai esant didelei šios ligos rizikai. Darbo uždaviniai : 1. Nustatyti prostatos vėžio dažnį esant didelei šios ligos rizikai (biopsinėje medžiagoje nustatyta aukšto laipsnio prostatos intraepitelinė neoplazija). 2. Įvertinti pakartotinių biopsijų reikšmę prostatos vėžio diagnozavimo dažniui. 3. Įvertinti tiriamojo vaisto reikšmę prostatos vėžio prevencijai (ar sumažina prostatos vėžio diagozavimo dažnį) esant didelei šios ligos rizikai. 4. Palyginti diagnozuoto prostatos vėžio diferenciacijos skirtumus tiriamosiose grupėse.
A high grade prostatic intraepithelial neoplasia (HPIN) is traditionally ascribed to pre-cancerous conditions or prostate cancer (PC) precursors, and associated with an increased risk of concomitant cancer or its later progression to malignant disease. After evaluation of the data indicating HPIN as a pre–cancerous condition, it is thought that the patients having HPIN in the prostate biopsy material are suitable candidates for chemoprevention.The aim of the study was to find out the significance of dutasteride, a 5–alpha reductase inhibitor, for the prevention of development of prostate cancer in case of a high risk for the disease. Objectives of the study: 1. To determine the rate of prostate cancer in case of a high risk for the disease (when a high grade prostatic intraepithelial neoplasia is found in biopsy material). 2. To find out the significance of repeat biopsies for the detection rate of prostate cancer. 3. To find out the significance of the investigatory medication for the prevention of development of prostate cancer in case of a high risk for the disease. 4. To compare the differences in the differentiation of diagnosed prostate cancer between the study groups.
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Winters, Ursula. "A Phase II Study of sequental therapy of imiquimod and phoyodynamic therapt for high grade vulval intraepithelial neoplasia". Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492735.

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Vulval intraepithelial neoplasia is a pre-malignant skin condition which is characterised by distressing symptoms of pruritis and dyspareunia; H is increasingly ' common in younger women and is often resistant to treatment. Radical vulval surgery is inappropriate because of the low rate of progression to malignant it disease and conservative excisional treatment often fails. These studies are an attempt to develop an acceptable alternative treatment which gives good long term results and maintains the normal vulval architecture.
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Xi, Long Fu. "Genomic variation of human papillomavirus type 16 in relation to risk for high grade cervical and anal intraepithelial neoplasia /". Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/10887.

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Chevarie-Davis, Myriam. "Long term predictive values of cervical cytology and Human Papillomavirus DNA testing for the development of biopsy proven high grade cervical intraepithelial neoplasia". Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107631.

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Cancer of the uterine cervix remains a significant cause of morbidity and mortality, even though it can be prevented by judiciously designed screening programs. Although many studies have compared Human Papillomavirus (HPV) DNA testing to cervical cytology, most of them have used cytology as an endpoint, thus being subject to outcome misclassification, or did not extend long enough to provide long term data. The aims of this project were to use the cervical cytology and HPV DNA test results performed in the context of a longitudinal cohort of over 10 years with repeated measurements to perform risk stratification for the development of cervical lesions confirmed by histology, the gold standard, and to compare the accuracy of both tests in the long term context. A cohort study of the natural history of HPV infection and cervical neoplasia was conducted in Brazil and enrolled 2462 women for questionnaire-based interviews and cervical screening according to a pre-established protocol. Whenever high-grade lesions were detected, subjects were referred for colposcopy and biopsy. Risk stratification was performed according to screening result, and the specificity, sensitivity and predictive values of HPV DNA testing and cytology were calculated. In addition, time-to-event analyses using Kaplan-Meier plots and Cox regression were performed. Low and high grade squamous intraepithelial lesions (SIL) on cytology, as well as the presence of high risk HPV DNA, all independently predicted high grade cervical lesions on biopsy in both the short and long term. When combined, the addition of HPV DNA testing to cytology was beneficial in cases of atypical smears, but not SIL. The long term negative predictive values were equivalent for negative cytology smears and negative HPV DNA tests. Dual testing with cytology and HPV DNA testing provided the best sensitivity and specificity over single modalities and other combinations.Elucidation of the performance and ideal use of screening tests in differing contexts contributes to our knowledge on cervical cancer screening, and allow us to develop optimal recommendations.
Le cancer du col de l'utérus demeure une cause significative de morbidité et de mortalité, malgré qu'elle puisse être prévenue par des programmes de dépistage bien conçus. Quoique de nombreuses études ont comparé le test de dépistage du virus du papillome humain (VPH) et la cytologie cervicale, plusieurs ont utilisé la cytologie comme résultat, devenant par le fait même susceptible de souffrir d'une classification erronée, et d'autres n'ont pas duré suffisamment longtemps pour recueillir des données à long terme. Les buts de ce projet étaient d'employer les résultats de cytologie et du test de VPH obtenus dans le contexte d'une étude de cohorte longitudinale s'étendant au delà de 10 ans afin de stratifier les risques de lésions cervicales tel que confirmé par histologie et de comparer les deux tests à long terme.Une étude de cohorte portant sur l'histoire naturelle des infections à VPH et sur les néoplasies cervicales a eu lieu au Brésil, recrutant 2462 femmes pour des entrevues et des tests de dépistages selon un protocole préétabli. Les participantes étaient référées en colposcopie dès qu'elles étaient diagnostiquées avec une lésion de haut grade. La stratification des risques a été complétée selon les résultats au dépistage, et la spécificité, sensibilité et les valeurs prédictives des tests utilisés ont été calculées. Les lésions intra épithéliales cervicales (LIC) de bas et de haut grades, ainsi que la détection de VPH de haut risque, ont tous prédit la présence de lésions cervicales de haut grade tant à cours terme qu'à long terme. L'ajout du test de dépistage du VPH à la cytologie était bénéfique dans les cas de résultats atypiques, mais pas pour les LIC. La valeur prédictive négative à long terme était équivalente pour les cytologies négatives et pour les tests de VPH négatifs. La combinaison des deux tests offrait la meilleure sensibilité et spécificité par rapport aux tests individuels ou à toute autre combinaison. Les découvertes portants sur la performance et l'utilisation idéale des tests de dépistages dans des contextes variés contribuent aux connaissances sur le dépistage du cancer du col de l'utérus, et nous permettent de développer des recommandations optimales.
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Fachini, Ana Maria Dias 1980. "Fatores de risco para diagnóstico histológico de lesão escamosa de alto grau em mulheres com resultado citológico de lesão de baixo grau = Risk factors for histological outcome of high-grade lesions in women with LSIL as shown by screening with cytology". [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310557.

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Orientador: Luiz Carlos Zeferino
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-28T01:58:16Z (GMT). No. of bitstreams: 1 Fachini_AnaMariaDias_M.pdf: 1042048 bytes, checksum: 6176c860fd833532ab405cd5f279c6ca (MD5) Previous issue date: 2015
Resumo: Introdução: A LIE-BG tem maior prevalência em mulheres jovens e a conduta expectante deve ser considerada ao invés da realização de testes para detecção de DNA-HPV. Mulheres com LIE-BG podem apresentar NIC 2 ou NIC 3 e, por este motivo, a conduta frente a este resultado deve selecionar as mulheres com maior risco para lesões mais graves. Objetivos: Avaliar a associação de alguns fatores de risco para diagnóstico histológico de lesão de alto grau em mulheres com resultado citológico de LIE-BG. Métodos: Este estudo incluiu 791 mulheres resultado de LIE-BG na citologia de rastreamento e que foram encaminhadas para colposcopia imediata. Ausência de neoplasia foi considerado o diagnóstico final em 235 mulheres nas quais a colposcopia foi normal. Outras 92 mulheres foram submetidas a excisão da zona de transformação. As variáveis analisadas foram: idade da mulher, idade de início de atividade sexual (IAS), tempo de atividade sexual (TAS) e adimplência ao rastreamento do câncer do colo útero. Resultados: Observou-se maior prevalência de NIC 3 e menor prevalência de casos sem neoplasia e NIC 1 nas mulheres com maior TAS. Inadimplência com o rastreamento está associada com maior prevalência de NIC 3 (OR=2.91; 1.27-6.63). A análise multivariada mostrou que NIC 3 está fortemente associado com TAS >10 anos quando comparado com TAS < 4 anos (OR=8.33; 1.82-33.33) e 5-9 anos (OR=7.69; 1.85-33.33) e essa associação foi limítrofe para a inadimplência com o rastreamento (OR=2.39; 0.96-5.92). A IAS não esteve associada a nenhum dos desfechos estudados. Conclusões: Mulheres com resultado citológico de LIE-BG têm maior probabilidade de revelar NIC 3 quando elas têm mais de 10 anos de tempo de atividade sexual e quando elas estão inadimplentes com o rastreamento do câncer do colo do útero. Essas mulheres devem ser encaminhadas imediatamente para colposcopia
Abstract: Introduction: LSIL shows higher prevalence in young women and conservative management should be considered other than HPV testing. Women with LSIL cytology may reveal CIN2 or CIN3 and for that reason the management should select the women with the higher risk for more severe lesions. Objectives: This study aimed to evaluate the association of some factors with histological outcome of women showing cytological LSIL. Methods: This study included 791 women with screening cytology showing LSIL who were referred to immediate colposcopy. The final diagnosis was considered "no neoplasia" for 235 women who had normal colposcopy. Other 92 women were undergone to excision of transformation zone. The variables analysed were woman's age, age of first sexual intercourse (FSI) and interval since FSI and screening compliance. Results: Higher interval since de FSI was associated with higher prevalence rate for CIN3 and lower prevalence rates for "no neoplasia" and CIN1. No screening compliance was associated with higher prevalence of CIN3 (OR=2.91; 1.27-6.63). Multivariate analysis showed that CIN 3 outcome was strongly associated with interval since FSI >10 years taking as reference <4 years (OR=8.33; 1.82-33.33) and 5-9 years (OR=7.69; 1.85-33.33) and it showed borderline association with no screening compliance (OR=2.39; 0.96-5.92). Age of FSI was not associated with any diagnosis. Conclusions: Women with LSIL screening cytology have higher probability to reveal CIN3 outcome when they have 10 or more years of since FSI and when they are non-compliant with cervical cancer screening. These women should have immediate colposcopy
Mestrado
Oncologia Ginecológica e Mamária
Mestre em Ciências da Saúde
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Hawes, Stephen Edward. "HIV-1, HIV-2, and dual infection with HIV-1 and HIV-2 are associated with increased risk for human papillomavirus (HPV) and high grade squamous intraepithelial lesions (HSIL) in Senegal, West Africa /". Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/10881.

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Bui, Loan Thuy. "Localisation of kallikreins in the prostate and association with prostate cancer progression". Queensland University of Technology, 2006. http://eprints.qut.edu.au/16276/.

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At present, prostate cancer is a significant public health issue throughout the world and is the second leading cause of cancer deaths in older men. The prostate specific antigen or PSA (which is encoded by the kallikrein 3/KLK3 gene) test is the current most valuable tool for the diagnosis and management of prostate cancer. However, it is insufficiently sensitive and specific for early diagnosis, for staging of prostate cancer or for discriminating between benign prostatic hyperplasia (BPH) and prostate cancer. Recent research has revealed another potential tumour marker, glandular kallikrein 2 (KLK2 gene/hK2 protein), which may be used alone or in conjunction with PSA to overcome some of the limitations of the PSA test. Twelve new kallikrein gene family members have been recently identified and, like hK2 and PSA, many of these genes have been suggested to be involved in carcinogenesis. In this study, the cellular localisation and level of expression of several of these newer kallikreins (KLK4, KLK5, KLK7, KLK8 and KLK11) was examined in prostate tissue, to provide an understanding of the association of their expression with prostatic diseases and their potential as additional biomarkers. Like PSA and hK2, the present observation indicated that each of these proteins, hK4, hK5, hK7, hK8 and hK11, was detected within the cytoplasm of the secretory cells of the prostate glands. For the first time, all of these newly-identified proteins were shown to be expressed in prostatic intraepithelial neoplasia (PIN) lesions, in comparison to normal glands and cancer lesions. In addition to cytoplasmic secretory cell expression, the localisation of hK4 to the basal cells and nuclei in prostatic lesions was intriguing. The intensity of hK4 staining in prostate tissue was strongest in comparison to the other newly-identified kallikrein proteins (hK5, hK7, hK8 and hK11). Therefore, KLK4/hK4 expression was characterised further to define this cellular localisation and examined in non-prostatic tissue and also in a larger number of prostate tissues in an attempt to determine its potential value as a biomarker for prostate disease. Three hK4 antipeptide polyclonal antibodies, derived against N-terminal, mid-region and C-terminal hK4 amino acid sequences, were used. The hK4 N-terminal antipeptide antibody was used to demonstrate the cellular localisation of hK4 in kidney, salivary glands, liver, testis, colon carcinoma, heart, endometrium and ovarian cancer, for the first time. The presence of hK4 in these non-prostate tissues was consistent with the previous reports using RT-PCR. The dual cytoplasmic and nuclear localisation of hK4 observed in the prostate above was also seen in these tissues. Although hK4 was found widely expressed in many human tissue types, indicating that it is not prostate specific in its expression, the highest expression level of hK4 was seen in the prostate. Therefore, detailed expression patterns and levels of KLK4 mRNA and hK4 protein in the normal prostate and prostatic diseases and histopathological lesions were investigated and reported for the first time in this study. Twelve benign prostatic hyperplasia (BPH), 19 adenocarcinoma (Gleason grade 2-5) and 34 bone metastases from prostate cancer were analysed. Using in situ hybridisation, the expression of KLK4 mRNA was detected in the cytoplasm of the secretory cells of both normal and diseased prostate tissue. KLK4 mRNA was also noted in both secretory and basal cells of PIN lesions, but the basal cells of normal glands were negative. Using the hK4 N-terminal and mid-region antipeptide antibodies, hK4 was predominantly localised in the cytoplasm of the secretory cells. The intensity of hK4 staining appeared lowest in normal and BPH, and increased in PIN lesions, high Gleason grade prostate cancer and bone metastases indicating the potential of hK4 as a histopathological marker for prostatic neoplasias. Further studies are required with a larger cohort to determine its utility as a clinical biomarker. Small foci of atypical cells, which were found within normal glands, were also intensely stained. Surprisingly, hK4 protein was found in the nucleus of the secretory cells (but not the basal cells) of high grade PIN and Gleason grade 3 prostate cancer. The detection of KLK4 mRNA and hK4 protein in PIN lesions and small foci of atypical cells suggests that up-regulation of KLK4 expression occurs early in the pathology of prostate carcinogenesis. The finding of basal cell expression is not typical for the kallikreins and it is not clear what role hK4 would play in this cell type. With the use of the hK4 C-terminal antipeptide antibody, the staining was mainly localised in the nuclei of the secretory cells of the prostate glands. Although the nuclear localisation was readily noted in more than 90% of epithelial cells of the prostate gland with the C-terminal antibody, no difference in staining intensity was observed among the histopathological lesions of the prostate. The prominent nuclear localisation with the C-terminal antipeptide antibody was also shown to be distributed throughout the nucleus by using confocal microscopy. Further, by using gold-labelled particles for electron microscopy, the intracellular localisation of these hK4 antipeptide antibodies was reported here for the first time. Similar to the immunohistochemical results, the cytoplasm was the major site of localisation with the N-terminal and mid-region antipeptide antibodies. To further characterise the involvement of KLK4/hK4 in human prostate cancer progression, the transgenic adenocarcinoma mouse prostate (TRAMP) model was used in this study. In this study, mouse KLK4 (also known as enamel matrix serine protease -1, EMSP-1) was shown to be expressed in the TRAMP prostate for the first time. Previous studies had only shown the developing tooth as a site of expression for EMSP-1. The level of EMSP-1 mRNA expression was increased in PIN and prostate cancer lesions of the TRAMP model, while negative or low levels of EMSP-1 mRNA were seen in normal glands or in control mouse prostate tissue. The normal mouse prostate did not stain with any the three hK4 antipeptide antibodies. hK4 N-terminal and mid-region antipeptide antibodies showed positive staining in the cytoplasm of the epithelial cells of PIN and cancer lesions of the mouse prostate. The C-terminal antipeptide antibody showed distinctively nuclear staining and was predominantly localised in the nuclei of the glandular cells of PIN and cancer lesions of the mouse prostate. The expression patterns of both the mRNA and protein level for mouse KLK4 strongly supported the observations of KLK4/hK4 expression in the human prostate and further support the utility of the TRAMP model. Overall, the findings in this thesis indicate a clear association of KLK4/hK4 expression with prostate cancer progression. In addition, several intriguing findings were made in terms of cellular localisation (basal as well as secretory cells; nuclear and cytoplasmic) and high expression in atypical glandular cells and PIN, perhaps indicating an early involvement in prostate disease progression and, additionally, utility as basal cell and PIN histological markers. These findings provide the basis for future studies to confirm the utility of hK4 as a biomarker for prostate cancer progression and identify functional roles in the different cellular compartments.
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Ramos, Kristina. "Chromosomal aberrations in high grade prostatic intraepithelial neoplasia and prostate cancer in African American men". Thesis, 2019. https://hdl.handle.net/2144/38683.

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Recent advances in whole genome sequencing have led to many discoveries in the mechanisms involved in carcinogenesis. Genomic characterization of premalignant lesions in numerous cancers has led to new prevention strategies, early detection, and treatment options that have saved lives and improved the quality of life for the people suffering from these cancers. Prostate cancer (PCa) is the most common cancer in men in the United States (US) and the second leading cause of death in men from all cancers. However, in African American men (AAM) the mortality rate from PCa is 2.4 times higher than European American men (EAM). In addition, AAM are more likely to get PCa and have a higher PCa burden at diagnosis than their EAM counterparts. This may suggest that there are racial/ethnic differences in the mechanism of carcinogenesis in PCa. PCa and its premalignant lesion, high grade prostatic intraepithelial neoplasia (HGPIN), are one of the most heterogeneous and complex cancers for scientists to determine the mechanisms of carcinogenesis. Due to this complexity, research on HGPIN and PCa has been difficult to carry out and interpret. Projects have been undertaken and progress has been made in the discovery of some genes involved in PCa and potential drivers of initiation, progression and aggressiveness of PCa. However, these studies have mostly been conducted among EAM and have little ethnic diversity. Discovery of new prevention, early detection and treatment methods for PCa will not be possible without advances in the genetic characterization of the pathways of carcinogenesis of PCa among ethnically diverse study populations. To date there are no known genetic characterizations of HGPIN and PCa in AAM. This study aims to characterize chromosomal copy number aberrations (CNA) in paired HGPIN and PCa in AAM. By utilizing advanced microarray techniques, we will determine the degree to which HGPIN and PCa share CNA and identify CNA that may be involved in PCa progression. This study will lay the foundation for future research into CNA that may be used as potential biomarkers for early detection of neoplasms of high-risk for development into PCa in AAM. The discovery of biomarkers and the characterization of the mechanisms involved in PCa progression may lead to treatment options for the prevention of PCa and an overall better outcome for AAM suffering from PCa.
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Libri sul tema "High grade prostatic intraepithelial neoplasia"

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Montironi, Rodolfo, Liang Cheng, Antonio Lopez-Beltran, Roberta Mazzucchelli, Matteo Santoni e Marina Scarpelli. Prostate cancer. A cura di James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0060.

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The incidence of prostate cancer (PCa) has risen dramatically in the last years. This event may be partially explained by the employment of digital rectal examination (DRE), serum prostate-specific antigen (PSA), and transrectal ultrasonography. In developed countries, PCa is the most frequent non-skin malignancy in males. It is estimated that one in six males will be diagnosed with PCa during their lifetime, the risk of death due to metastatic PCa being 1 in 30. Multiple factors contribute to the development of PCa, as well as to its progression to an androgen-independent state: dietary factors, inherited susceptibility factors, gene defects, and androgens and their receptors. The chapter will discuss the following topics: high-grade prostatic intraepithelial neoplasia (PIN); atypical small acinar proliferation; morphological criteria for the identification of PCa; reporting of PCa biopsies; prognostic factors in radical prostatectomies (RPs); and specimens.
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Capitoli di libri sul tema "High grade prostatic intraepithelial neoplasia"

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Shah, Rajal B., e Ming Zhou. "High-Grade Prostatic Intraepithelial Neoplasia". In Prostate Biopsy Interpretation, 133–41. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-13601-7_9.

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Cimadamore, Alessia, Maria Rosaria Raspollini e Rodolfo Montironi. "High-Grade Prostatic Intraepithelial Neoplasia". In Encyclopedia of Pathology, 145–46. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-41894-6_4915.

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Brimo, Fadi. "High-Grade Prostatic Intraepithelial Neoplasia". In Molecular Pathology Library, 27–36. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64096-9_3.

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Shah, Rajal B., e Ming Zhou. "High-Grade Prostatic Intraepithelial Neoplasia". In Prostate Biopsy Interpretation: An Illustrated Guide, 121–30. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-21369-4_9.

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Cimadamore, Alessia, Maria Rosaria Raspollini e Rodolfo Montironi. "High-Grade Prostatic Intraepithelial Neoplasia". In Encyclopedia of Pathology, 1–3. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-28845-1_4915-1.

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Ramaswamy, Krishna, Herbert Lepor e Samir S. Taneja. "Management of High-Grade Prostatic Intraepithelial Neoplasia (HGPIN)". In Prostate Cancer Diagnosis, 241–54. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-188-2_18.

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Garcia, Fernando U., Kevin L. Bashman e Mark S. Austenfeld. "Quantitative Effects of Antiandrogen Therapy on High-Grade Prostatic Intraepithelial Neoplasia in Radical Prostatectomy Specimens". In Hormonal Carcinogenesis II, 398–403. New York, NY: Springer New York, 1996. http://dx.doi.org/10.1007/978-1-4612-2332-0_53.

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Weizer, Alon Z., Scott M. Gilbert, David P. Wood e Rajal B. Shah. "Management and Controversies of High-Grade Prostatic Intraepithelial Neoplasia and Atypical Small Acinar Proliferation on Prostate Biopsy". In Prostate Biopsy, 269–86. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-078-6_19.

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Welton, Mark Lane. "Anal Intraepithelial Neoplasia (AIN)/High-Grade Squamous Intraepithelial Lesion (HSIL)". In Complexities in Colorectal Surgery, 351–61. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9022-7_22.

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Reid, R. "Genital Warts and Cervical Cancer: A Colposcopic Index for Differentiating Benign Papillomaviral Infection from High-Grade Intraepithelial Neoplasia". In Gynecology and Obstetrics, 431–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70559-5_146.

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Atti di convegni sul tema "High grade prostatic intraepithelial neoplasia"

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Jung, Seung-Hyun, Sun Shin, Sug Hyung Lee e Yeun-Jun Chung. "Abstract 153: Patterns of genetic progression in high grade prostatic intraepithelial neoplasia". In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-153.

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Hajiran, Cyrus J., e Letha J. Sooter. "Abstract A151: Identification of antibody fragments specific for high-grade prostatic intraepithelial neoplasia cells via SELEX." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-a151.

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Kumar, Nagi B., Julio Pow-Sang, Kathleen M. Egan, Philippe A. Spiess, Shohreh Dickinson, Raoul Salup, Mohamed Helal et al. "Abstract PR06: Effect of polyphenon E on progression to prostate cancer after diagnosis of high grade prostatic intraepithelial neoplasia". In Abstracts: Thirteenth Annual AACR International Conference on Frontiers in Cancer Prevention Research; September 27 - October 1, 2014; New Orleans, LA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1940-6215.prev-14-pr06.

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Fowke, Jay H., Saundra Motley e Susan Byerly. "Abstract 2175: Prospective association between obesity and statin use with conversion from high-grade prostatic intraepithelial neoplasia (HGPIN) to prostate cancer (PC)". In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2175.

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Gann, Peter H., Ryan Deaton, Erika Enk, Richard B. van Breemen, Misop Han, Yi Lu e Viju Ananthanarayanan. "Abstract 3564: A Phase II randomized trial of lycopene-rich tomato extract among men with high-grade prostatic intraepithelial neoplasia (HGPIN)". In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3564.

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KUMAR, Nagi, Michael Schell, Ganna Chornokur e Cathy Phelan. "Abstract B67: Effect of polyphenon E on progression to prostate cancer after diagnosis of high-grade prostatic intraepithelial neoplasia or atypical small acinar proliferation in African American men". In Abstracts: Seventh AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; November 9-12, 2014; San Antonio, TX. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7755.disp14-b67.

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Carbinatto, Fernanda M., Natália M. Inada, Welington Lombardi, Eduardo V. da Silva, Renata Belotto, Cristina Kurachi e Vanderlei S. Bagnato. "Photodynamic therapy of Cervical Intraepithelial Neoplasia (CIN) high grade". In SPIE BiOS, a cura di Bernard Choi, Nikiforos Kollias, Haishan Zeng, Hyun Wook Kang, Brian J. F. Wong, Justus F. Ilgner, Guillermo J. Tearney et al. SPIE, 2016. http://dx.doi.org/10.1117/12.2213339.

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Grimm, D., IJ Lang, K. Prieske, S. Mathey, S. Kürti, E. Burandt, B. Schmalfeldt e L. Wölber. "Course of high-grade cervical intraepithelial neoplasia diagnosed during pregnancy". In 62. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe – DGGG'18. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1671021.

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Kupinski, Meredith, Matthieu Boffety, Razvigor Ossikovski, Angelo Pierangelo, Jean Rehbinder, Jérémy Vizet, F. Goudail e Tatiana Novikova. "Diagnostics of high grade cervical intraepithelial neoplasia with Mueller matrix polarimetry". In Novel Biophotonics Techniques and Applications, a cura di Arjen Amelink e Seemantini K. Nadkarni. SPIE, 2019. http://dx.doi.org/10.1117/12.2527117.

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Lendvai, Agnes, Frank Johannes, Christina Grimm, Jasper JH Eijsink, Rene Wardenaar, Haukeline H. Volders, Harry G. Klip et al. "Abstract 5011: Genome-wide methylation profiling identifies hypermethylated biomarkers in high-grade cervical intraepithelial neoplasia". In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-5011.

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Rapporti di organizzazioni sul tema "High grade prostatic intraepithelial neoplasia"

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Fowke, Jay H. Molecular Markers of Estrogen Metabolism and Progression From High-Grade Prostatic Intraepithelial Neoplasia (HGPIN) to Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, marzo 2004. http://dx.doi.org/10.21236/ada423460.

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Fowke, Jay H., Fritz Parl, Quiyin Cai e Scott Shappell. Molecular Markers of Estrogen Metabolism and Progression From High-Grade Prostatic Intraepithelial Neoplasia (HGPIN) to Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, marzo 2003. http://dx.doi.org/10.21236/ada420161.

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