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1

Tarannum, Lubna. "Stroke in Young at High Altitude". Indian Journal of Emergency Medicine 6, n. 1 (2020): 41–44. http://dx.doi.org/10.21088/ijem.2395.311x.6120.7.

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Tranmer, B. I., e G. W. Kindt. "High altitude". Neurosurgery 17, n. 2 (agosto 1985): 320???3. http://dx.doi.org/10.1097/00006123-198508000-00013.

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Hevroni, Avigdor, Aliza Goldman e Eitan Kerem. "High Altitude". Clinical Pulmonary Medicine 22, n. 3 (maggio 2015): 105–13. http://dx.doi.org/10.1097/cpm.0000000000000093.

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Heffernan, Olive. "High altitude". Nature Climate Change 1, n. 910 (17 settembre 2009): 110. http://dx.doi.org/10.1038/climate.2009.90.

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Driver, Carolyn. "High altitude". Practice Nursing 15, n. 6 (giugno 2004): 295–97. http://dx.doi.org/10.12968/pnur.2004.15.6.13160.

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Luks, Andrew M., Erik R. Swenson e Peter Bärtsch. "Acute high-altitude sickness". European Respiratory Review 26, n. 143 (31 gennaio 2017): 160096. http://dx.doi.org/10.1183/16000617.0096-2016.

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Abstract (sommario):
At any point 1–5 days following ascent to altitudes ≥2500 m, individuals are at risk of developing one of three forms of acute altitude illness: acute mountain sickness, a syndrome of nonspecific symptoms including headache, lassitude, dizziness and nausea; high-altitude cerebral oedema, a potentially fatal illness characterised by ataxia, decreased consciousness and characteristic changes on magnetic resonance imaging; and high-altitude pulmonary oedema, a noncardiogenic form of pulmonary oedema resulting from excessive hypoxic pulmonary vasoconstriction which can be fatal if not recognised and treated promptly. This review provides detailed information about each of these important clinical entities. After reviewing the clinical features, epidemiology and current understanding of the pathophysiology of each disorder, we describe the current pharmacological and nonpharmacological approaches to the prevention and treatment of these diseases.
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Shupp, Aaron M., e Rustem Igor Gamow. "Hawaii High Altitude Study: High Altitude Sleeping System". Wilderness & Environmental Medicine 15, n. 2 (giugno 2004): 154. http://dx.doi.org/10.1580/1080-6032(2004)015[0155:hhasha]2.0.co;2.

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PHILLIPSON, E. A. "Humans at High Altitude: High Altitude and Man." Science 228, n. 4696 (12 aprile 1985): 171. http://dx.doi.org/10.1126/science.228.4696.171.

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Chun, Hua, Yan Yue, Yibin Wang, Zhaxi Dawa, Pu Zhen, Qu La, Yang Zong, Yi Qu e Dezhi Mu. "High prevalence of congenital heart disease at high altitudes in Tibet". European Journal of Preventive Cardiology 26, n. 7 (12 novembre 2018): 756–59. http://dx.doi.org/10.1177/2047487318812502.

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Background Previous small sample studies suggested that elevated altitudes might be associated with the incidence of cardiovascular diseases. However, it remains uncertain whether high altitudes (over 3000 m above sea level) are related to congenital heart disease. We therefore explored the prevalence of congenital heart disease in a large cohort of students in the world's largest prefecture-level city with the highest altitude. Methods This cross-sectional study included 84,302 student participants (boys 52.12%, girls 47.88%, with an average age of 10.62 ± 3.33 years). Data were extracted from the screening results among different altitude area schools in Nagqu from June 2016 to August 2017. Students were first screened by performing a physical examination consisting of cardiac auscultations and clinical manifestation screenings. An echocardiography was performed to confirm and identify the subtype of congenital heart disease. Results The prevalence of congenital heart disease among students in Nagqu, Tibet, was 5.21‰ (439 cases). The most common congenital heart disease type was patent ductus arteriosus, representing 66.3% of congenital heart diseases diagnosed in this study, followed by atrial septal defect and ventricular septal defect, representing 20.3% and 9.1% of congenital heart diseases, respectively. Students living in higher altitudes were significantly more prone to have congenital heart disease than students in locations with lower altitudes. The prevalence of congenital heart disease in girls was found to be higher than that of boys. Conclusions The correlation between congenital heart disease and increased altitude is noteworthy. This study's results are the first big data epidemiological investigation to confirm that high altitude is a significant environmental risk factor for congenital heart disease, especially patent ductus arteriosus. Furthermore, the results provide additional support to make a diagnostic and treatment plan to prevent congenital heart disease in high altitude areas.
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Snyder, L. R. "Low P50 in deer mice native to high altitude". Journal of Applied Physiology 58, n. 1 (1 gennaio 1985): 193–99. http://dx.doi.org/10.1152/jappl.1985.58.1.193.

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Whereas it is widely believed that animals native to high altitude show lower O2 partial pressures at 50% hemoglobin saturation (P50) than do related animals native to low altitude, that “fact” has not been well documented. Consequently, P50 at pH 7.4, PCO2(7.4), the CO2 Bohr effect, and the buffer slope (delta log PCO2/delta pH) were determined via the mixing technique in Peromyscus maniculatus native to a range of altitudes but acclimated to 340 or 3,800 m. PCO2(7.4) and buffer slope were substantially lower at high altitude. The change in P50(7.4) between acclimation altitudes was minimal (0.8% increase at 3,800 m), because of counterbalancing changes in PCO2, 2,3-diphospho-D-glycerate concentration, and perhaps other factors. At both acclimation altitudes there was a highly significant negative correlation between P50(7.4) and native altitude. Since pH in vivo probably increases slightly at high altitude, the data on P50 corrected to pH 7.4 are probably underestimates of the difference in in vivo P50 at low vs. high altitude. Hence these results corroborate theoretical predictions that low P50 is advantageous under severe hypoxic stress.
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11

Wiedman, Michael, e Geoffrey C. Tabin. "High-altitude retinopathy and altitude illness". Ophthalmology 106, n. 10 (ottobre 1999): 1924–27. http://dx.doi.org/10.1016/s0161-6420(99)90402-5.

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Sieg, Birgit, Birgit Drees e Thilo Hasse. "High-altitude vegetation of continental West Greenland". Phytocoenologia 39, n. 1 (18 marzo 2009): 27–50. http://dx.doi.org/10.1127/0340-269x/2009/0039-0027.

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Bogar, K., e P. Schatz. "Altitude and Concussions in the NFL: Is There Really a “Mile-High” Effect?" Archives of Clinical Neuropsychology 34, n. 5 (luglio 2019): 759. http://dx.doi.org/10.1093/arclin/acz026.29.

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Abstract Purpose The literature on altitude and concussions in football shows some evidence of protective effects of living and training and playing at high altitudes. We explored the likelihood of sustaining concussions within the AFC West division, specifically comparing games hosted at high altitude in Denver versus games hosted by at low altitudes in Los Angeles, Oakland, and Kansas City. Methods Information was recorded for all regular season AFC West division games (N= 42) occurring in the 2012–2018 seasons. Altitude for each stadium was calculated using DaftLogic’s Google Sandbox. Concussion incidence for the 2012–2018 seasons was collected from PBS Frontline’s Concussion-Watch and weekly injury reports (NFL.com). Chi-square analyses compared likelihood of: concussions occurring in High Altitude versus Low Altitude, a Broncos player sustaining a concussion in High Altitude versus Low Altitude, and a non-Broncos AFC West player sustain a concussion in High Altitude versus Low Altitude. Results Chi-square analyses revealed no greater likelihood of players sustaining concussions in High Altitude versus Low Altitude (p=.35), or of Broncos (p=1.00) or non-Broncos (p=.47) AFC West players sustaining concussions in High Altitude versus Low Altitude. Conclusion Altitude is not a significant factor for increased likelihood of concussions, and popular theories such as “the mile-high effect” are not supported by the data. We found no evidence for the proposed protective factor of living and training at high altitude for Broncos team members, as they showed an equal likelihood of sustaining a concussion at high and low altitude.
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Jiao, Jun, Bifeng Song, Yubin Li, Yugang Zhang e Jianhua Xu. "Development of a testing methodology for high-altitude propeller". Aircraft Engineering and Aerospace Technology 90, n. 9 (14 novembre 2018): 1486–94. http://dx.doi.org/10.1108/aeat-02-2017-0069.

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Purpose The purpose of this paper is to develop a propeller performance measurement method for high-altitude platforms by analyzing of the propeller aerodynamic characteristics and application of a mobile testing system. Design/methodology/approach An experimental approach is adopted for this study. Considering the aerodynamic characteristics of the high-altitude propeller, the similitude of the scaled propeller model in the experiment is analyzed and determined. Then, the experimental method and procedure to obtain the propeller’s performance under different altitudes are presented, and the structure of hardware and software and the key techniques of the testing system are introduced in detail. Findings The applicability and effectiveness of the testing system is verified through comparison between experimental and numerical results. In addition, the performance of the 6.8-m propeller for a high-altitude airship is tested, which proves that the high-altitude propeller can meet the requirements of the propulsion system. Practical implications The testing methodology and the mobile testing system could be applied to aerodynamic performance evaluation of the high-altitude propellers under different altitudes. Originality/value This testing approach exhibits significant time and cost benefits over many other experimental methods to obtain the performance of the high-altitude propellers, which is important in the preliminary design of the propulsion system for high-altitude platforms.
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Weinstein, Y., M. H. Bernstein, P. E. Bickler, D. V. Gonzales, F. C. Samaniego e M. A. Escobedo. "Blood respiratory properties in pigeons at high altitudes: effects of acclimation". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 249, n. 6 (1 dicembre 1985): R765—R775. http://dx.doi.org/10.1152/ajpregu.1985.249.6.r765.

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Many birds thrive at high altitudes where environmental temperatures are low. Previous studies have shown that tolerance of and acclimation to hypoxia involve cardiopulmonary and hematological adaptations. We investigated blood respiratory properties during exposure to simulated high altitude (hypobaric hypoxia) and low temperature in unanesthetized resting pigeons (Columbia livia, mean mass 0.38 kg). A control group (C) and a group acclimated to 7 km above sea level (ASL) in a hypobaric chamber at 25 degrees C (HA group) were used. All were acutely exposed to altitudes through 9 km ASL at 5 or 25 degrees C. Arterial and mixed venous blood gas tensions and O2 and CO2 content during steady state decreased with increased altitude, whereas blood lactate increased in both groups at both temperatures. Acute high-altitude exposure did not affect hematocrit, hemoglobin concentrations, or O2 carrying capacity, but at any altitude these were all greater in HA than in C birds. At 5 degrees C blood pH increased with altitude in controls but remained unchanged in HA birds. At 25 degrees C in both groups mean intracellular pH did not change, averaging 6.97, whereas extracellular (venous) pH increased with altitude. At the highest altitudes tissue O2 extraction was virtually complete in both groups. Acclimation changed blood O2 and CO2 combining properties in ways likely to improve gas transport at high altitudes. The previously unreported shifts in blood respiratory and acid-base properties with acclimation indicate that innate extrapulmonary adaptations contribute to avian hypoxia tolerance.
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16

Zhu, Lu-lu, Zhi-jun Ma, Ming Ren, Yu-miao Wei, Yu-hua Liao, You-lu Shen, Shi-ming Fan et al. "Distinct Features of Gut Microbiota in High-Altitude Tibetan and Middle-Altitude Han Hypertensive Patients". Cardiology Research and Practice 2020 (21 novembre 2020): 1–15. http://dx.doi.org/10.1155/2020/1957843.

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Indigenous animals show unique gut microbiota (GM) in the Tibetan plateau. However, it is unknown whether the hypertensive indigenous people in plateau also have the distinct gut bacteria, different from those living in plains. We sequenced the V3-V4 region of the gut bacteria 16S ribosomal RNA (rRNA) gene of feces samples among hypertensive patients (HPs) and healthy individuals (HIs) from 3 distinct altitudes: Tibetans from high altitude (3600–4500 m, n = 38 and 34), Hans from middle altitude (2260 m, n = 49 and 35), and Hans from low altitude (13 m, n = 34 and 35) and then analyzed the GM composition among hypertensive and healthy subgroups using the bioinformatics analysis, respectively. The GM of high-altitude Tibetan and middle-altitude Han HPs presented greater α- and β-diversities, lower ratio of Firmicutes/Bacteroidetes (F/B), and higher abundance of beneficial Verrucomicrobia and Akkermansia than the low-altitudes HPs did. The GM of high-altitude Tibetan and middle-altitude HIs showed greater α-diversity and lower ratio of F/B than the low-altitudes HIs did. But, β-diversity and abundance of Verrucomicrobia and Akkermansia among different subgroups of HIs did not show any differences. Conclusively, the high-altitude Tibetan and middle-altitude Han HPs have a distinct feature of GM, which may be important in their adaptation to hypertension in the plateau environments.
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17

Chapman, Robert F., Trine Karlsen, Geir K. Resaland, R. L. Ge, Matthew P. Harber, Sarah Witkowski, James Stray-Gundersen e Benjamin D. Levine. "Defining the “dose” of altitude training: how high to live for optimal sea level performance enhancement". Journal of Applied Physiology 116, n. 6 (15 marzo 2014): 595–603. http://dx.doi.org/10.1152/japplphysiol.00634.2013.

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Chronic living at altitudes of ∼2,500 m causes consistent hematological acclimatization in most, but not all, groups of athletes; however, responses of erythropoietin (EPO) and red cell mass to a given altitude show substantial individual variability. We hypothesized that athletes living at higher altitudes would experience greater improvements in sea level performance, secondary to greater hematological acclimatization, compared with athletes living at lower altitudes. After 4 wk of group sea level training and testing, 48 collegiate distance runners (32 men, 16 women) were randomly assigned to one of four living altitudes (1,780, 2,085, 2,454, or 2,800 m). All athletes trained together daily at a common altitude from 1,250–3,000 m following a modified live high-train low model. Subjects completed hematological, metabolic, and performance measures at sea level, before and after altitude training; EPO was assessed at various time points while at altitude. On return from altitude, 3,000-m time trial performance was significantly improved in groups living at the middle two altitudes (2,085 and 2,454 m), but not in groups living at 1,780 and 2,800 m. EPO was significantly higher in all groups at 24 and 48 h, but returned to sea level baseline after 72 h in the 1,780-m group. Erythrocyte volume was significantly higher within all groups after return from altitude and was not different between groups. These data suggest that, when completing a 4-wk altitude camp following the live high-train low model, there is a target altitude between 2,000 and 2,500 m that produces an optimal acclimatization response for sea level performance.
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de Aquino Lemos, Valdir, Ronaldo Vagner Thomatieli dos Santos, Fabio Santos Lira, Bruno Rodrigues, Sergio Tufik e Marco Tulio de Mello. "Can High Altitude Influence Cytokines and Sleep?" Mediators of Inflammation 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/279365.

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The number of persons who relocate to regions of high altitude for work, pleasure, sport, or residence increases every year. It is known that the reduced supply of oxygen (O2) induced by acute or chronic increases in altitude stimulates the body to adapt to new metabolic challenges imposed by hypoxia. Sleep can suffer partial fragmentation because of the exposure to high altitudes, and these changes have been described as one of the responsible factors for the many consequences at high altitudes. We conducted a review of the literature during the period from 1987 to 2012. This work explored the relationships among inflammation, hypoxia and sleep in the period of adaptation and examined a novel mechanism that might explain the harmful effects of altitude on sleep, involving increased Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) production from several tissues and cells, such as leukocytes and cells from skeletal muscle and brain.
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Serrano-Dueñas, Marcos. "High-altitude headache". Expert Review of Neurotherapeutics 7, n. 3 (marzo 2007): 245–48. http://dx.doi.org/10.1586/14737175.7.3.245.

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Steele, Peter. "High-altitude guiding". Wilderness & Environmental Medicine 10, n. 4 (dicembre 1999): 215. http://dx.doi.org/10.1580/1080-6032(1999)010[0215:hag]2.3.co;2.

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Berglund, Bo. "High-Altitude Training". Sports Medicine 14, n. 5 (novembre 1992): 289–303. http://dx.doi.org/10.2165/00007256-199214050-00002.

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Klocke, David L. "High Altitude Medicine". Mayo Clinic Proceedings 73, n. 9 (settembre 1998): 918. http://dx.doi.org/10.4065/73.9.918.

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SKOLNIK, NEIL, e WILLIAM VAUGHAN. "High-Altitude Sickness". Family Practice News 42, n. 6 (aprile 2012): 35–36. http://dx.doi.org/10.1016/s0300-7073(12)70292-x.

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Benedetti, Fabrizio, Jennifer Durando, Lucia Giudetti, Alan Pampallona e Sergio Vighetti. "High-altitude headache". PAIN 156, n. 11 (novembre 2015): 2326–36. http://dx.doi.org/10.1097/j.pain.0000000000000288.

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Murdoch, D. "High-altitude illness". Ophthalmology 107, n. 7 (luglio 2000): 1212. http://dx.doi.org/10.1016/s0161-6420(00)00103-2.

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Paralikar, SwapnilJ, e JagdishH Paralikar. "High-altitude medicine". Indian Journal of Occupational and Environmental Medicine 14, n. 1 (2010): 6. http://dx.doi.org/10.4103/0019-5278.64608.

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Singh, GK. "High altitude dermatology". Indian Journal of Dermatology 62, n. 1 (2017): 59. http://dx.doi.org/10.4103/0019-5154.198050.

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Pardiñas Barón, N., F. Fernández Fernández, F. Fondevila Camps, M. L. Giner Muñoz e M. Ara Báguena. "High-altitude retinopathy". Archivos de la Sociedad Española de Oftalmología (English Edition) 87, n. 10 (ottobre 2012): 337–39. http://dx.doi.org/10.1016/j.oftale.2011.09.007.

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Zafren, Ken, e Benjamin Honigman. "HIGH-ALTITUDE MEDICINE". Emergency Medicine Clinics of North America 15, n. 1 (febbraio 1997): 191–222. http://dx.doi.org/10.1016/s0733-8627(05)70291-1.

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Clarke, Charles. "High altitude medicine". Travel Medicine and Infectious Disease 3, n. 4 (novembre 2005): 189–97. http://dx.doi.org/10.1016/j.tmaid.2004.11.006.

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Bezruchka, Stephen. "High altitude medicine". Medical Clinics of North America 76, n. 6 (novembre 1992): 1481–97. http://dx.doi.org/10.1016/s0025-7125(16)30298-x.

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Woods, D. R., S. Allen, T. R. Betts, D. Gardiner, H. Montgomery, J. M. Morgan e P. R. Roberts. "High Altitude Arrhythmias". Cardiology 111, n. 4 (2008): 239–46. http://dx.doi.org/10.1159/000127445.

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Dietz, Thomas E. "High Altitude Web". High Altitude Medicine & Biology 8, n. 2 (giugno 2007): 84–87. http://dx.doi.org/10.1089/ham.2007.8204.

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Dietz, Thomas E. "High Altitude Web". High Altitude Medicine & Biology 8, n. 3 (agosto 2007): 181–83. http://dx.doi.org/10.1089/ham.2007.8304.

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Dietz, Thomas E. "High Altitude Web". High Altitude Medicine & Biology 8, n. 4 (dicembre 2007): 273–77. http://dx.doi.org/10.1089/ham.2007.8404.

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Dietz, Thomas E. "HIGH ALTITUDE WEB". High Altitude Medicine & Biology 9, n. 1 (marzo 2008): 11–14. http://dx.doi.org/10.1089/ham.2008.6543.

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Dietz, Thomas E. "High Altitude Web". High Altitude Medicine & Biology 9, n. 2 (giugno 2008): 108–10. http://dx.doi.org/10.1089/ham.2008.9204.

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Dietz, Thomas E. "High Altitude Web". High Altitude Medicine & Biology 9, n. 3 (settembre 2008): 193–94. http://dx.doi.org/10.1089/ham.2008.9304.

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Dietz, Thomas. "High Altitude Web". High Altitude Medicine & Biology 9, n. 4 (dicembre 2008): 261–63. http://dx.doi.org/10.1089/ham.2008.9404.

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Dietz, Thomas E. "HIGH ALTITUDE WEB". High Altitude Medicine & Biology 10, n. 1 (marzo 2009): 9–10. http://dx.doi.org/10.1089/ham.2009.10104.

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Dietz, Thomas E. "High Altitude Web". High Altitude Medicine & Biology 5, n. 3 (settembre 2004): 310–13. http://dx.doi.org/10.1089/ham.2004.5.310.

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Dietz, Thomas E. "High Altitude Web". High Altitude Medicine & Biology 5, n. 4 (dicembre 2004): 395–98. http://dx.doi.org/10.1089/ham.2004.5.395.

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Dietz, Thomas E. "High Altitude Web". High Altitude Medicine & Biology 6, n. 1 (marzo 2005): 11–13. http://dx.doi.org/10.1089/ham.2005.6.11.

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Dietz, Thomas E. "High Altitude Web". High Altitude Medicine & Biology 6, n. 3 (settembre 2005): 205–8. http://dx.doi.org/10.1089/ham.2005.6.205.

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Dietz, Thomas. "High Altitude Web". High Altitude Medicine & Biology 6, n. 4 (dicembre 2005): 286–88. http://dx.doi.org/10.1089/ham.2005.6.286.

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Dietz, Thomas E. "High Altitude Web". High Altitude Medicine & Biology 6, n. 2 (giugno 2005): 92–96. http://dx.doi.org/10.1089/ham.2005.6.92.

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Dietz, Thomas E. "High Altitude Web". High Altitude Medicine & Biology 8, n. 1 (marzo 2007): 10–12. http://dx.doi.org/10.1089/ham.2006.0818.

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Dietz, Thomas E. "High altitude Web". High Altitude Medicine & Biology 7, n. 2 (giugno 2006): 102–4. http://dx.doi.org/10.1089/ham.2006.7.102.

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Dietz, Thomas E. "High Altitude Web". High Altitude Medicine & Biology 7, n. 1 (marzo 2006): 14–16. http://dx.doi.org/10.1089/ham.2006.7.14.

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Dietz, Thomas E. "High Altitude Web". High Altitude Medicine & Biology 7, n. 3 (settembre 2006): 190–92. http://dx.doi.org/10.1089/ham.2006.7.190.

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