Bibliografie tematiche / HIFU therapy

Letteratura scientifica selezionata sul tema "HIFU therapy"

Autore: Grafiati

Pubblicato: 1 giugno 2024

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Articoli di riviste sul tema "HIFU therapy":

Bespalov, Vladimir, Grigoriy Tochilnikov, Konstantin Senchik, Yelena Yermakova, Yelizaveta Kovalevskaya, Georgiy Gafton e A. Berkovich. "HIGH-INTENSITY FOCUSED ULTRASOUND IN THE TREATMENT OF MALIGNANT AND BENIGN TUMORS". Problems in oncology 66, n. 1 (1 gennaio 2020): 29–35. http://dx.doi.org/10.37469/0507-3758-2020-66-1-29-35.

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The review article discusses the possibilities of using high-intensity focused ultrasound (HIFU) in oncology. The technical principles and features of HIFU ablation, a brief history of the development of HIFU therapy, the principles of HIFU therapy, the physical basis of the HIFU ablation method, and the mechanisms of antitumor action of HIFU therapy are presented. The results and benefits of HIFU therapy for various malignant and benign tumors are discussed.

Gunderman, Anthony, Rudy Montayre, Ashish Ranjan e Yue Chen. "Review of Robot-Assisted HIFU Therapy". Sensors 23, n. 7 (3 aprile 2023): 3707. http://dx.doi.org/10.3390/s23073707.

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This paper provides an overview of current robot-assisted high-intensity focused ultrasound (HIFU) systems for image-guided therapies. HIFU is a minimally invasive technique that relies on the thermo-mechanical effects of focused ultrasound waves to perform clinical treatments, such as tumor ablation, mild hyperthermia adjuvant to radiation or chemotherapy, vein occlusion, and many others. HIFU is typically performed under ultrasound (USgHIFU) or magnetic resonance imaging guidance (MRgHIFU), which provide intra-operative monitoring of treatment outcomes. Robot-assisted HIFU probe manipulation provides precise HIFU focal control to avoid damage to surrounding sensitive anatomy, such as blood vessels, nerve bundles, or adjacent organs. These clinical and technical benefits have promoted the rapid adoption of robot-assisted HIFU in the past several decades. This paper aims to present the recent developments of robot-assisted HIFU by summarizing the key features and clinical applications of each system. The paper concludes with a comparison and discussion of future perspectives on robot-assisted HIFU.

Sofuni, Atsushi, Yasutsugu Asai, Takayoshi Tsuchiya, Kentaro Ishii, Reina Tanaka, Ryosuke Tonozuka, Mitsuyoshi Honjo et al. "Novel Therapeutic Method for Unresectable Pancreatic Cancer—The Impact of the Long-Term Research in Therapeutic Effect of High-Intensity Focused Ultrasound (HIFU) Therapy". Current Oncology 28, n. 6 (20 novembre 2021): 4845–61. http://dx.doi.org/10.3390/curroncol28060409.

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High-intensity focused ultrasound (HIFU) is a novel advanced therapy for unresectable pancreatic cancer (PC). HIFU therapy with chemotherapy is being promoted as a novel method to control local advancement by tumor ablation. We evaluated the therapeutic effects of HIFU therapy in locally advanced and metastatic PC. PC patients were treated with HIFU as an optional local therapy and systemic chemotherapy. The FEP-BY02 (Yuande Bio-Medical Engineering) HIFU device was used under ultrasound guidance. Of 176 PC patients, 89 cases were Stage III and 87 were Stage IV. The rate of complete tumor ablation was 90.3%, while that of symptom relief was 66.7%. The effectiveness on the primary lesions were as follows: complete response (CR): n = 0, partial response (PR): n = 21, stable disease (SD): n = 106, and progressive disease (PD): n = 49; the primary disease control rate was 72.2%. Eight patients underwent surgery. The median survival time (MST) after diagnosis for HIFU with chemotherapy compared to chemotherapy alone (100 patients in our hospital) was 648 vs. 288 days (p < 0.001). Compared with chemotherapy alone, the combination of HIFU therapy and chemotherapy demonstrated significant prolongation of prognosis. This study suggests that HIFU therapy has the potential to be a novel combination therapy for unresectable PC.

Ge, Hui-Yu, Li-Ying Miao, Jin-Rui Wang, Liu-Lin Xiong, Fang Yan, Cui-Shan Zheng, Jian-Wen Jia, Li-Gang Cui e Wen Chen. "Correlation between Ultrasound Reflection Intensity and Tumor Ablation Ratio of Late-Stage Pancreatic Carcinoma in HIFU Therapy: Dynamic Observation on Ultrasound Reflection Intensity". Scientific World Journal 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/852874.

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The minimally invasive high-intensity focused ultrasound (HIFU) therapy is thermal ablation treatment for late-stage pancreatic carcinoma with widely recognized safety and effectiveness, but there are currently no instant assessment methods for its ablation effect. It is vital to find a real-time high-sensitive assessment method. This research aims to dynamically observe the variation rules of ultrasound reflection intensity, analyze the correlation between ultrasound reflection intensity and tumor ablation ratio, and find out the value of ultrasound reflection intensity in prognosis of HIFU ablation effect. HIFU intermittent therapies were retrospectively analyzed for 31 subjects with late-stage pancreatic carcinoma from March 2007 to December 2009 in the study. The variation rules of the ultrasound reflection intensity during HIFU therapy were summarized and the correlation between ultrasound reflection intensity and tumor ablation ratio was analyzed based on the tumor ablation ratio indicated by CT scanning. The conclusion is that variation of ultrasound reflection intensity can be used for initial assessment of tumor ablation in HIFU therapy and early prognosis of overall HIFU ablation, providing important clinical basis for improving safety and effectiveness of HIFU therapy. Ultrasound can work as a real-time imaging instrument for observation of HIFU ablation effect in treating late-stage pancreatic carcinoma.

Liu, Li, e Jian Sun. "A Study of Temperature Measurement Technique of High Intensity Focusing Ultrasonic Therapy". Applied Mechanics and Materials 201-202 (ottobre 2012): 521–24. http://dx.doi.org/10.4028/www.scientific.net/amm.201-202.521.

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High intensity focused ultrasound (HIFU) is the fourth brand-new and efficient means to cure tumour acknowledged by the medical field. China is one of countries applying HIFU to clinical oncotherapy earliest in the world. However, a considerable part of HIFU equipments which have been put on the market leave unused because accidental injuries such as ambustion to the body surface, tumour tissue residues in the target section or damages to normal tissues are often caused in HIFU clinical treatment. In the thesis, temperature measurement technique of high-intensity focusing ultrasonic therapy is introduced; features and existing problems of two methods (ultrasound and MRI) which are usually used at home and abroad to guide and monitor HIFU treatment are focally analyzed and illustrated.

Yu, Tinghe, e Xiao Fu. "Extracorporeal Ultrasound-Guided High Intensity Focused Ultrasound: Implications from the Present Clinical Trials". Scientific World Journal 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/537260.

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Extracorporeal ultrasound-guided high intensity focused ultrasound (HIFU) has been clinically used for 15 years, and over 36000 cases have been reported. However, there yet lacked a consensus in the clinical values, suggesting the necessity of checking clinical findings. Clinical trials were searched and data reevaluated. HIFU was hardly performed alone; almost all present anticancer means have been applied during an HIFU treatment, and a specific regimen varied between trials; there were heterogeneity and disagreement between trials. The complexity made it difficult to distinguish the effect of HIFU. Based upon evaluable data, the efficacy of HIFU was similar to that of radio frequency, chemoembolization, chemotherapy, radiotherapy, or hormone therapy; a combined therapy did not improve the efficacy. The survival rate of HIFU plus radiotherapy was lower than that of radical surgery in liver cancers. Adverse events had no downtrend in the past years. HIFU was not a standardized procedure where the intensity and insonation mode were modified constantly throughout a treatment, limiting an evaluation from the perspective of ultrasonics. These implied that HIFU should be applied as an alternative at most occasions. The present clinical trials had defects making against the understating of HIFU.

Vargas-Olivares, A., O. Navarro-Hinojosa, M. Maqueo-Vicencio, L. Curiel, M. Alencastre-Miranda e J. E. Chong-Quero. "Segmentation Method for Magnetic Resonance-Guided High-Intensity Focused Ultrasound Therapy Planning". Journal of Healthcare Engineering 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/5703216.

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High-intensity focused ultrasound (HIFU) is a minimally invasive therapy modality in which ultrasound beams are concentrated at a focal region, producing a rise of temperature and selective ablation within the focal volume and leaving surrounding tissues intact. HIFU has been proposed for the safe ablation of both malignant and benign tissues and as an agent for drug delivery. Magnetic resonance imaging (MRI) has been proposed as guidance and monitoring method for the therapy. The identification of regions of interest is a crucial procedure in HIFU therapy planning. This procedure is performed in the MR images. The purpose of the present research work is to implement a time-efficient and functional segmentation scheme, based on the watershed segmentation algorithm, for the MR images used for the HIFU therapy planning. The achievement of a segmentation process with functional results is feasible, but preliminary image processing steps are required in order to define the markers for the segmentation algorithm. Moreover, the segmentation scheme is applied in parallel to an MR image data set through the use of a thread pool, achieving a near real-time execution and making a contribution to solve the time-consuming problem of the HIFU therapy planning.

Pasticier, Gilles, Ji-Wann Lee, Sebastien Crouzet, J. Soria, Christelle Medollima, Florence Mege-Lechevallier, Jean-Yves Chapelon, Olivier Rouviere e Albert Gelet. "Localized prostate cancer and salvage treatment: EBRT first + salvage HIFU or HIFU first + salvage EBRT? A single-institution matched pair analysis over a 20-year period." Journal of Clinical Oncology 35, n. 6_suppl (20 febbraio 2017): 77. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.77.

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77 Background: In the field of curative treatment for localized prostate cancer, HIFU (High Intensity Focused ultrasound) is one of salvage option after EBRT(external beam radiation therapy) failure and EBRT is the standard salvage option for local relapse after HIFU.Our aim was to compare and evaluate the oncologic outcomes between HIFU first + salvage EBRT versus EBRT first +salvage HIFU. Methods: Using a matched pair analysis, 342 Patients (171 in each group) treated between 1994 and 2014 in the same institution were prospectively followed and matched to a 1:1 basis. Outcome measurements: Overall Survival Rate(OSR), cancer specific(CSSR) and metastasis free (MFSR) survival rates were the primary endpoints. Secondary endpoints were survival rate free of hormone therapy (HTFR) and the rate of side effects Clavien score ≥ 3. Results: Mean follow-up were 114 and 124 months for HIFU+ S-EBRT and EBRT + S-HIFU respectively. At 7 years from the primary treatment , the MFSR were significantly better after HIFU first +S- EBRT than after EBRT first+S- HIFU: 96% vs 91%% (p:0.011). The OSR and the CSSR were not significantly different in the two arms (97% and 99% after HIFU+S- EBRT versus 96% and 98% after EBRT+S- HIFU). The HTFR at 7 years was significantly different (p <0.001) after HIFU+ S-EBRT than after EBRT+ S-HIFU 90% versus 69%. In multivariable Cox regression, the initial Gleason sum ≥ 8 and the treatment strategy were predictors of MFSR (risk ratio 3.2 for treatment modality). The rate of side effect Clavien score≥ 3 was significantly higher (p:0.01) in the EBRT+ S-HIFU arm than in the HIFU+ S-EBRT arm. The rate of urinary toxicity (severe incontinence and bladder outlet obstruction) were worse in the EBRT+ S-HIFU arm than in HIFU+S-EBRT arm: 9.4% and 15.2% vs 1.2% and 7.6% (p:0.01 and 0.078). Conclusions: In this single-institution Matched Pair comparison, the MFSR and HTFR were significantly better in the HIFU+S-EBRT arm than in the EBRT+S-HIFU arm. The rate of urinairy toxicity and Clavien≥3 side-effects were Higher in the EBRT + S-HIFU arm than in the HIFU + S-EBRT arm.

He, G.-B., W. Luo, X.-D. Zhou, L.-W. Liu, M. Yu e X.-D. Ma. "A preliminary clinical study on high-intensity focused ultrasound therapy for tubal pregnancy". Scottish Medical Journal 56, n. 4 (novembre 2011): 214–19. http://dx.doi.org/10.1258/smj.2011.011161.

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Our aim was to explore the clinical application value of high-intensity focused ultrasound (HIFU) therapy for tubal pregnancy. Forty hospitalized patients with tubal pregnancies (28 cases of non-ruptured tubal pregnancy and 12 cases of ruptured tubal pregnancy) were selected to receive HIFU therapy. Serum human chorionic gonadotropin (β-HCG) concentrations were compared before and after treatment. Serum β-HCG was measured weekly and patients received observation only if the concentration decreased by 15% or more, compared with the previous value. Patients were given supplement HIFU therapy if the decrease in the serum β-HCG was <15% within two weeks. Ultrasound was used to detect the volume changes in the ectopic lesions before and after treatment, and changes in vital signs and complications were recorded. Contrast-enhanced ultrasonography was used to assess fallopian tube patency after treatment. HIFU treatment was successful in 33 of the 40 patients (82%). Seven patients failed HIFU treatment and received surgical therapy (18%). Before and after treatment, serum β-HCG concentrations and lesion volume were significantly different ( P < 0.05, P < 0.01, respectively). Post-treatment tubal contrast-enhanced ultrasonography showed tubal patency on the affected side in 21 cases (64%) at six months and in 27 cases (82%) at 12 months. In conclusion, HIFU is safe and effective, and can be a treatment option for tubal pregnancy.

Feng, Sui, Yingjie Qu, Yuquan Meng e Jinjin Zheng. "Use thermophysical property to quantify state of HIFU treatment for VLS". E3S Web of Conferences 185 (2020): 03045. http://dx.doi.org/10.1051/e3sconf/202018503045.

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The aim of this study is to evaluate the performance of ADT methods in grading the effectiveness of HIFU treatment for VLS. High-intensity focused ultrasound has been identified as a promising treatment modality for vulvar lichen sclerosus, a common inflammatory disorder associated with an increased risk of developing vulvar carcinoma. With small probe on extensive VLS parts, the therapy was sometimes uneven, thus the total doses of HIFU machine couldn’t indicate the curative effect at each part. The current therapeutic effect was based on symptoms and skin appearance after 3 months, which was time-consuming. Until now, there has been no immediate quantitative assessment method of HIFU therapeutic response for VLS. In our study, active dynamic IR thermal (ADT) was scheduled to undergo HIFU therapy before and after treatment. The thermal time constant was calculated based on ADT images measured both before and after HIFU treatment. In the result of pig phantom measurements, with each part approximately the same thermal time constant before HIFU treatment, the change of thermal time constant was strictly positively associated with HIFU dose onto each part. This study demonstrates the clinical potential of ADT in fast and effective quantify state of HIFU treatment for VLS.

Più fonti

Tesi sul tema "HIFU therapy":

Ritchie, Robert Wilson. "Improving clinical outcomes in renal HIFU therapy". Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572839.

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The rising incidence of small, asymptomatic renal tumours discovered usmg abdominal imaging during the investigation of unrelated symptoms has fuelled the desire for new therapies which avoid surgical excision. Extracorporeal High Intensity Focused Ultrasound (HIFU) was proposed as one of these modalities but so far clinical research has been ,~." inconclusive. The present work was designed to improve these clii teal outcomes through the conduct of further clinical trials, laboratory based research and the translation of new technology into existing HIFU devices. A Phase II clinical trial of patients (n=13) with newly diagnosed <4cm renal tumours (clinical stage T1a) was designed, peer reviewed and received ethical approval (Ox REC 09/H0606104). Ten of 13 patients underwent renal HIFU using a clinical HIFU device (Model JCIJC200, HAIFU, China). One patient could not be treated due to poor tumour visualisation after anaesthesia and two patients could not be treated as they became unwell before or during anaesthesia. Histological evidence of HIFU ablation in either tumour or normal renal parenchyma was seen in all ten patients. Evidence of sub-total tumour ablation was seen in 8/10 of patients. Grade 1 «50%), 2 (50-90%) & 3 (90-99%) ablation was achieved in 4/10, 3/1 0 & 3/1 0 patients respectively but complete (100%) tumour ablation was not possible. HIFU treatment caused minimal morbidity - no Grade III- V (Clavien-Dindo) complications related to HIFU treatment occurred. Grade I skin pain and induration was seen in 9/1 0 patients; Grade II skin pain occurred in a single patient. Patient demographics, imaging and tumour characteristics were used to design parameters to improve patient selection for renal HIFU. The tumour location, thickness of peri-nephric fat and renal nephrometry score were useful predictors of successful screening for treatment. Page /ii Dr R. W Ritchie Nutiield Department of Surgical Sciences - TT 2012 Abstract Diligent use of these factors could limit unnecessary treatments and Improve ablation outcomes. , It is well known that ultrasound imaging of small renal masses can be challenging. Ultrasound imaging often deteriorates further during HIFU as the abdominal wall and fat tissues swell and cause increased attenuation. This loss of imaging quality was clearly demonstrated in this clinical trial and resulted in the early termination of treatment, before ,#,J' ... ~ .•.. endpoints were reached, in a number of cases. The current clinical method for monitoring the success of HIFU ablation using hyperecho analysis of B-mode ultrasound images is also questionable. Laboratory based studies using ex-vivo bovine liver subjected to HIFU confirmed that hyperecho monitoring had low sensitivity, predictive values and overall accuracy. A novel method of HIFU monitoring - passive mapping of the emissions received from acoustic cavitation activity and other sources of non-linearity during HIFU treatment - is believed to represent a significant opportunity to improve feedback. This technique uses the passively received signature of cavity activity which, when time-reversed, gives high- resolution images of the precise location of the activity. Laboratory-based ex-vivo work, using a commercially available ultrasound system (z.one, Zonare, USA), demonstrates its superiority over hyperecho monitoring. Indeed, thresholds could be applied to successfully predict HIFU ablation with high sensitivity and specificity. This technique was successfully translated into the clinical setting through the design of a Passive Acoustic Mapping (P AM) device. Custom-built receiving elements were applied without limiting the function of the existing HIFU devices. Both pre-clinical and ethically- Page [iii Dr R. W Ritchie Nuffield Department of Surgical Sciences - TT 2012 Abstract approved clinical studies demonstrated its safe integration without significant impact on the device energy output or treatment accuracy. Using similar passive beamfonning algorithms, acoustic cavitation activity was successfully mapped and corresponded with the location of thermal ablation in both ex-vivo tissue phantoms and during clinical HIFU therapy. ,~-' It is believed that the development of new patient selection paral~~tel's will elimil?ate target those patients who are most suitable for renal HIFU - small tumours, minimal peri-nephric fat & low nephrometry score .. The use of P AM will lead to a significant improvement in the efficacy of treatment. It can be successfully applied to existing devices and predicts the location and extent ofHIFU ablation with greater accuracy that existing techniques.

Rabkin, Brian Alan. "High-intensity focused ultrasound (HIFU) induced hyperechoic regions for the ultrasound guidance of HIFU therapy /". Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8037.

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Ye, Guoliang. "Model-based ultrasonic temperature estimation for monitoring HIFU therapy". Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:6f4c4f84-3ca6-46f2-a895-ab0aa3d9af51.

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High Intensity Focused Ultrasound (HIFU) is a new cancer thermal therapy method which has achieved encouraging results in clinics recently. However, the lack of a temperature monitoring makes it hard to apply widely, safely and efficiently. Conventional ultrasonic temperature estimation based on echo strain suffers from artifacts caused by signal distortion over time, leading to poor estimation and visualization of the 2D temperature map. This thesis presents a novel model-based stochastic framework for ultrasonic temperature estimation, which combines the temperature information from the ultrasound images and a theoretical model of the heat diffusion. Consequently the temperature estimation is more consistent over time and its visualisation is improved. There are 3 main contributions of this thesis related to: improving the conventional echo strain method to estimate temperature, developing and applying approximate heat models to model temperature, and finally combining the estimation and the models. First in the echo strain based temperature estimation, a robust displacement estimator is first introduced to remove displacement outliers caused by the signal distortion over time due to the thermo-acoustic lens effect. To transfer the echo strain to temperature more accurately, an experimental method is designed to model their relationship using polynomials. Experimental results on a gelatine phantom show that the accuracy of the temperature estimation is of the order of 0.1 ◦C. This is better than results reported previously of 0.5 ◦C in a rubber phantom. Second in the temperature modelling, heat models are derived approximately as Gaussian functions which are mathematically simple. Simulated results demonstrate that the approximate heat models are reasonable. The simulated temperature result is analytical and hence computed in much less than 1 second, while the conventional simulation of using finite element methods requires about 25 minutes under the same conditions. Finally, combining the estimation and the heat models is the main contribution of this thesis. A 2D spatial adaptive Kalman filter with the predictive step defined by the shape model from the heat models is applied to the temperature map estimated from ultrasound images. It is shown that use of the temperature shape model enables more reliable temperature estimation in the presence of distorted or blurred strain measurements which are typically found in practice. The experimental results on in-vitro bovine liver show that the visualisation on the temperature map over time is more consistent and the iso-temperature contours are clearly visualised.

Anand, Ajay. "Noninvasive temperature estimation technique for HIFU therapy monitoring using backscattered ultrasound /". Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/5867.

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Dasgupta, Subhashish. "Improved Characterization of the High Intensity Focused Ultrasound (HIFU) induced Thermal Field". University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1275936679.

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Fosnight, Tyler R. "Echo Decorrelation Imaging of In Vivo HIFU and Bulk Ultrasound Ablation". University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1447691239.

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Gyöngy, Miklós. "Passive cavitation mapping for monitoring ultrasound therapy". Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:af6f3c5a-bec5-4378-a617-c89d2b16d95d.

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Cavitation is a phenomenon present during many ultrasound therapies, including the thermal ablation of malignant tissue using high intensity focused ultrasound (HIFU). Inertial cavitation, in particular, has been previously shown to result in increased heat deposition and to be associated with broadband noise emissions that can be readily monitored using a passive receiver without interference from the main ultrasound signal. The present work demonstrates how an array of passive receivers can be used to generate maps of cavitation distribution during HIFU exposure, uncovering a new potential method of monitoring HIFU treatment. Using a commercially available ultrasound system (z.one, Zonare, USA), pulse transmission can be switched off and data from 64 elements of an array can be simultaneously acquired to generate passive maps of acoustic source power. For the present work, a 38 mm aperture 5-10 MHz linear array was used, with the 64 elements chosen to span the entire aperture. Theory and simulations were used to show the spatial resolution of the system, the latter showing that the broadband nature of inertial cavitation makes passive maps robust to interference between cavitating bubbles. Passive source mapping was first applied to wire scatterers, demonstrating the ability of the system to resolve broadband sources. With the array transversely placed to the HIFU axis, high-resolution passive maps are generated, and emissions from several cavitating bubbles are resolved. The sensitivity of passive mapping during HIFU exposure is compared with that of an active cavitation detector following exposure. The array was then placed within a rectangular opening in the centre of the HIFU transducer, providing a geometric setup that could be used clinically to monitor HIFU treatment. Cavitation was instigated in continuous and disjoint regions in agar tissue mimicking gel, with the expected regions of cavitation validating the passive maps obtained. Finally, passive maps were generated for samples of ox liver exposed to HIFU. The onset of inertial cavitation as detected by the passive mapping approach was found to provide a much more robust indicator of lesioning than post-exposure B-mode hyperecho, which is in current clinical use. Passive maps based on the broadband component of the received signal were able to localize the lesions both transversely and axially, however cavitation is generally indicated 5 mm prefocal to the lesions. Further work is needed to establish the source of this discrepancy. It is believed that with use of an appropriately designed cavitation detection array, passive mapping will represent a major advance in ultrasound-guided HIFU therapy. Not only can it be utilized in real-time during HIFU exposure, without the need to turn the therapeutic ultrasound field off, but it has also been shown in the context of the present work to provide a strong indicator of successful lesioning and high signal-to-noise compared to conventional B-mode ultrasound techniques.

Pernot, Mathieu. "Nouvelles techniques de thérapie ultrasonore et de monitoring". Phd thesis, Université Paris-Diderot - Paris VII, 2004. http://pastel.archives-ouvertes.fr/pastel-00000992.

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High Intensity Focused Ultrasound (HIFU) is a promising technique for the treatment of localized cancers. The ability to focus ultrasound precisely on a predetermined volume allows the possibility of selective tissue destruction at this position without damage to surrounding tissues. However, many difficulties remain in the treatment of deep-seated tumors. In this thesis, new therapeutic and monitoring techniques are proposed to address these problems, by using phased arrays of ultrasound transducers. Two monitoring techniques based on the detection of the displacements of the ultrasonic speckle are developed, and allowed us to image the changes in the temperature and the shear modulus during HIFU therapy. In-vitro ultrasound-guided experiments are performed. Secondly, the problem of organs motion during the treatment is addressed. A method for real-time tracking the 3D motion of tissues is combined with a 2D High Intensity Focused Ultrasound multi-channel system in order to correct the respiratory motion during HIFU therapies. In the last section of this thesis, a high power ultrasonic system is developed for transcranial HIFU brain therapy. The skulls aberrations are corrected using a time reversal mirror thanks to an implanted hydrophone. In-vivo experiments are conducted on 22 sheep with minimally invasive surgery. Finally, a non-invasive protocol based on CT scans of the entire skull is developed and allows the prediction of the skulls aberrations and the skull overheating.

Holroyd, David. "Effect of blood flow on high intensity focused ultrasound therapy in an isolated, perfused liver model". Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:89f8f435-373d-46c2-92c8-5e9d21b4f01d.

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High intensity focused ultrasound (HIFU) is an emerging non-invasive thermal ablative modality that can be utilised for the treatment of solid organ tumours, including liver cancer. Acoustic cavitation is a phenomenon that can occur during HIFU and its presence can enhance heating rates. One major limitation of thermal ablative techniques in general, such as radiofrequency and microwave ablation, is the heat sink effect imparted by large vasculature. Thermal advection from blood flow in vessels ≥ 3 - 4 mm in diameter has been shown to significantly reduce heating rates and peak temperatures in the target tissue, potentially leading to treatment failure. With regards to HIFU therapy, a clearer understanding is required of the effects of blood flow on heating, cavitation and thermal tissue necrosis, which is the treatment endpoint in clinical thermal ablation. Therefore, the overall aim of this thesis project was to elucidate the effects of blood flow on HIFU-induced heating, cavitation and histological assessment of thermal ablation. A unique isolated, perfused porcine liver model was used in order to provide a relevant test bed, with physiological and anatomical characteristics similar to the in vivo human liver. The normothermic liver perfusion device used in all studies presented in this work can keep an organ alive in a functional state ex vivo for in excess of 72 hours. A further advantage of the liver perfusion device was that it allowed blood flow to be stopped completely and resumed rapidly, allowing studies to be conducted under zero flow conditions. A therapeutic HIFU system was used in order to deliver HIFU therapy to regions of hepatic parenchyma adjacent (≤ 3 mm) to large (≥ 5 mm) blood vessels or away from vasculature (≥ 1 cm) at either 1.06 MHz or at 3.18 MHz. Cavitation events during HIFU therapy were spatio-temporally monitored using a previously developed passive acoustic mapping (PAM) technique. The cavitation threshold at each frequency was determined through assessment of acoustic emissions acquired through PAM during HIFU exposure at a range of acoustic pressures. Real time thermal data during HIFU therapy were obtained using an implantable 400 μm thermocouple, aligned with the HIFU focus, in order to assess the effect of large vessel blood flow on peak tissue temperatures. Thermal data were obtained at 1.06 MHz, in the presence of acoustic cavitation and at 3.18 MHz, in the absence of cavitation, both in the presence and complete absence of blood flow. Finally, histological assessment of cell viability and cell death was performed in order to determine whether any heat sink effect could be overcome, with the achievement of complete tissue necrosis in treatment regions directly adjacent to large vasculature. This work demonstrated for the first time that in perfused, functional liver tissue, the presence of large vasculature and physiological blood flow does not significantly affect ablative HIFU therapy, both in terms of peak focal tissue temperatures attained and histological evidence of complete tissue necrosis. Therefore, HIFU may be superior to other ablative modalities in treating tumours in tissue regions adjacent to major vascular structures, but further work needs to be performed to correlate the experimental findings with clinical outcomes.

Souchon, Rémi Chapelon Jean-Yves. "Application de l'élastographie à l'imagerie du cancer de la prostate et à sa thérapie par ultrasons focalisés rostate cancer detection and HIFU therapy monitoring using elastography /". Villeurbanne : Doc'INSA, 2005. http://docinsa.insa-lyon.fr/these/pont.php?id=souchon.

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Thèse doctorat : Images et Systèmes : Villeurbanne, INSA : 2004.
Thèse rédigée en anglais. Introduction et conclusion en français et en anglais. Titre provenant de l'écran-titre. Bibliogr. p. 113-118. Publications de l'auteur, 3 p.

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Libri sul tema "HIFU therapy":

Chŏn, Yang-suk. Chongyang ŭi sansŏnghwa e ŭihan HIF-1[alpha] kwabarhyŏn kijŏn kyumyŏng kwa saeroun hangam chʻiryo tʻaget ŭi palgul =: Mechanism of HIF-1[alpha] overexpression in acidified tumor and novel target for anticancer therapy. [Seoul]: Pogŏn Pokchibu, 2007.

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Kanno, Hiroshi, e Joachim P. Steinbach. Familial tumour syndromes: von Hippel–Lindau disease. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199651870.003.0016.

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Von Hippel–Lindau (VHL) disease, an autosomal dominant familial tumour syndrome, is often associated with haemangioblastoma of the central nervous system. In the presence of oxygen, VHL protein serves to prevent the accumulation of hypoxia-inducible factor (HIF) protein by targeting it to the proteasomal pathway, while biallelic inactivation of the VHL gene blocks degradation of HIF and leads to constitutive activation of the HIF pathway although oxygen is present. HIF-target genes are involved in angiogenesis, proliferation, and metabolism enabling tumour growth. Haemangioblastoma is a highly vascularized, begin tumour commonly associated with a cyst, but it is linked with neurological morbidity and mortality based on its location and multiplicity. Haemangioblastoma in VHL is diagnosed according to symptoms and signs, past and family histories, laboratory data, neuroradiological findings, pathological findings, and genetic testing. Surgical treatment is usually the most recommended therapy for haemangioblastomas, and using well-defined microsurgical techniques, the majority can be resected safely.

Capitoli di libri sul tema "HIFU therapy":

Crouzet, Sébastien. "Salvage Focal HIFU". In Focal Therapy of Prostate Cancer, 95–98. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-14160-2_9.

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Martin-Fiori, Ernst, e Beat Werner. "Functional Neurosurgery with MR-Guided HIFU". In Intraoperative Imaging and Image-Guided Therapy, 591–99. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7657-3_45.

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Pahlevan, Roozbeh, e Farnaz Keyhanlou. "HIFU and RF Therapy in Facial Rejuvenation". In Integrated Procedures in Facial Cosmetic Surgery, 437–44. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-46993-1_35.

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Ye, Mingzhu. "Adjuvant Therapy of HIFU Ablation for Adenomyosis". In Adenomyosis, 143–48. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4095-4_16.

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Crouzet, Sebastien, Olivier Rouvière, Cyril Lafond, Jean-Yves Chapelon e Albert Gelet. "Focal High-Intensity Focused Ultrasound (HIFU)". In Technical Aspects of Focal Therapy in Localized Prostate Cancer, 137–51. Paris: Springer Paris, 2014. http://dx.doi.org/10.1007/978-2-8178-0484-2_12.

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Esnault, Olivier, e Laurence Leenhardt. "High Intensity Focused Ultrasound (HIFU) Ablation Therapy for Thyroid Nodules". In Thyroid Ultrasound and Ultrasound-Guided FNA, 219–36. Boston, MA: Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-77634-7_13.

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Ganzer, Roman. "How to Create Evidence for Focal PCa Therapy Research? HIFU Focal Hemiablation as Non-invasive Therapeutic Option". In Focal Therapy of Prostate Cancer, 87–94. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-14160-2_8.

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Thüroff, Stefan, e Christian G. Chaussy. "Transrectal Prostate Cancer Ablation by Robotic High-Intensity Focused Ultrasound (HIFU) at 3 MHz: 18 Years Clinical Experiences". In Focal Therapy of Prostate Cancer, 105–33. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-14160-2_11.

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Yukhnev, Andrey, Dmitriy Tarkhov, Yakov Gataulin, Yana Ivanova e Alexander Berkovich. "Neural Network Methods of HIFU-Therapy Control by Infrared Thermography and Ultrasound Thermometry". In Advances in Neural Networks – ISNN 2019, 595–602. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-22808-8_59.

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Senoo, N., H. Ushijima, J. Suzuki, K. Yoshinaka, J. Deguchi, S. Takagi, T. Miyata e Y. Matsumoto. "Development of High Intensity Focused Ultrasound (HIFU) Therapy for Lower Extremity Varicose Veins". In IFMBE Proceedings, 1323–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-14515-5_337.

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Atti di convegni sul tema "HIFU therapy":

Pauly, K. B., V. Rieke, A. B. Holbrook, W. Grissom, J. Chen e E. Kaye. "MR-guidance of HIFU therapy". In 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2009. http://dx.doi.org/10.1109/iembs.2009.5334680.

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Park, Chan Yuk, Da Sol Kwon, Jin Ho Sung e Jong Seob Jeong. "High Intensity Focused Ultrasound Transducer Using Inversion Layer Technique for Ultrasound Therapy". In 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3369.

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Recently, high intensity focused ultrasound (HIFU) has been used for non-invasive surgery of prostate, uterus, and brain. However, a HIFU therapy is suffered from relatively long surgical time mainly due to small focal area per each sonication. In order to solve this problem, a HIFU therapy using multi-frequency was suggested by several researchers, and they demonstrated that this technique can increase the area of the coagulated lesion due to enhanced cavitation effect compared to single-frequency HIFU [1–3]. To generate multi-frequency especially dual-frequency, dual-element and dual-layer HIFU transducers have been developed and provided an expanded lesion size [1–3]. In this study, we present an alternative technique of making dual-frequency HIFU transducer using inversion layer technique. Generally, a single layer piezoelectric element can excite the strong fundamental resonance (f0) and the weak odd-order harmonic resonance (3f0) [4]. In the inversion layer technique, on the other hand, a piezoelectric component consisting of two piezo-ceramic plates bonded together with opposite poling directions and different thicknesses can produce the relatively strong even-order harmonic (2f0) in addition to the fundamental resonance [5]. Additionally, only a pair of electrode at the outside of the each piezo-ceramic plate is required to stimulate dual-frequency ultrasound while two pairs of electrodes are typically required for conventional dual-element and dual-layer transducers [2,3]. A specially designed prototype HIFU transducer was built, and we verified that the dual-frequency ultrasound was successfully generated through electrical impedance and pulse-echo response measurements.

Okita, Kohei, Ryuta Narumi, Takashi Azuma, Shu Takagi e Yoichiro Matsumoto. "Modeling and Simulation of High-Intensity Focused Ultrasound Therapy for Breast Cancer". In ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fmd2013-16055.

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Therapeutic application of ultrasound is of interest for a tumor treatment, thrombolysis, drag delivery, blood-brain barrier opening and so on. High-intensity focused ultrasound (HIFU) therapy has been developed as the noninvasive treatment deep cancers in particular. Issues as the defocusing and distortion of ultrasound in the body and the long treatment time in current HIFU should be resolved quickly. Numerical simulation is required for the early development of the advance HIFU system.

Khokhlova, T. D. "Optoacoustic Monitoring of HIFU Therapy: Feasibility Study". In THERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound. AIP, 2006. http://dx.doi.org/10.1063/1.2205462.

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Ziadloo, Ali, e Shahram Vaezy. "Real-time 3D image-guided HIFU therapy". In 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2008. http://dx.doi.org/10.1109/iembs.2008.4650201.

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Yuan, Fang, Chris Pua, Pei Zhong e Yunbo Liu. "HIFU-Induced Gene Activation in a Cell-Embedded Tissue Mimicking Phantom". In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-43996.

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The synergistic integration of high intensity focused ultrasound (HIFU) thermal ablation and HIFU-induced gene therapy represents a promising approach in improving the overall efficacy and quality of cancer therapy. Previous studies have demonstrated that HIFU can induce GFP gene activation under the control of hsp70B promoter in a murine tumor model [1]. Thermal stress has been identified as the primary mechanism to regulate the gene expression. However, the natural heterogeneity and opacity of solid tumors has hindered direct correlation of site-specific gene expression level with in situ thermal dosimetry. We have developed a homogeneous and transparent cell-embedded tissue mimicking phantom as an alternative for simultaneous assessment of temperature distribution, HIFU lesion formation, and gene expression.

Zhu, Yiying I., Timothy L. Hall e Oliver D. Kripfgans. "Programmable Ultrasound Phased Array Therapy System". In 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3370.

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There has been an emerging interest in high intensity focused ultrasound (HIFU) for therapeutic applications. By means of its thermal or mechanical effects, HIFU is able to serve as a direct tool for tissue ablation, or an indirect moderating medium to manipulate microbubbles or perform heating (hyperthermia) for the purpose of targeted drug delivery. The development and testing of HIFU based phased arrays is favorable as their elements allow for individual phasing to steer and focus the beam. While FDA has already approved tissue ablation by HIFU for the treatment of uterine fibroids (2004) and pain from bone metastases (2012), development continues on other possible applications that are less forgiving of incomplete treatment, such as thermal necrosis of malignant masses. Ideally, each element, of such an array must have its own fully programmable electrical driving channel, which allows the control of delay, phase, and amplitude of the output from each element. To enable full control, each channel needs a waveform generator, an amplification device, and an impedance matching circuit between driver and acoustic element. Similar projects utilizing this approach to drive therapeutic arrays include a 512-channel therapy system which was built at the University of Michigan using low cost Field-Programmable Gate Arrays (FPGA) microcontroller and highly efficient MOSFET switching amplifiers [1]. However, this system lacks the ability to drive both, continuous wave (CW) and transient short duty-cycle high power pulses. This paper presents a hybrid system, which is able to perform CW and transient short duty-cycle high power excitation. In the following we will describe the design, programming, fabrication, and evaluation of this radiofrequency (RF) driver system as used in our laboratory for a 1.5 MHz center frequency, 298-element array (Imasonic SA, Besancon, France) [2], FPGA-controlled amplifier boards and matching circuitry. Advantages of our design include: 1. Inexpensive components (<$15/channel); 2. Ability to program/drive individual output channels independently; 3. Sufficient time and amplitude resolution for various acoustic pattern design; 4. Capability of hybrid switching between low power CW and short duty cycle, high instantaneous power.

Chitnis, Parag V., Hans P. Brecht, Richard Su, Alexander A. Oraevsky, Yoichiro Matsumoto, Lawrence A. Crum e Gail Reinette ter Haar. "Optoacoustic Imaging for Guiding and Monitoring HIFU Therapy". In 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010). AIP, 2011. http://dx.doi.org/10.1063/1.3607879.

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Zhong, P., F. Xing, X. Huang, H. Zhu, H. W. Lo, X. Zhong, S. Pruitt et al. "HIFU as a Neoadjuvant Therapy in Cancer Treatment". In 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010). AIP, 2011. http://dx.doi.org/10.1063/1.3607920.

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Xiaorui, Chen, Zhang Xiaojing, Wang Shaolin e Jian Xiqi. "Simulation of the therapeutic region during HIFU therapy". In 2011 4th International Conference on Biomedical Engineering and Informatics (BMEI). IEEE, 2011. http://dx.doi.org/10.1109/bmei.2011.6098400.

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Rapporti di organizzazioni sul tema "HIFU therapy":

Li, Yu. Noninvasive MR-Guided HIFU Therapy of TSC-Associated Renal Angiomyolipomas. Fort Belvoir, VA: Defense Technical Information Center, settembre 2014. http://dx.doi.org/10.21236/ada609479.

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Li, Yu. Non-invasive MR-guided HIFU Therapy of TSC-Associated Renal Angiomyolipomas. Fort Belvoir, VA: Defense Technical Information Center, luglio 2012. http://dx.doi.org/10.21236/ada566994.

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Li, Yu. Non-invasive MR-guided HIFU Therapy of TSC-Associated Renal Angiomyolipomas. Fort Belvoir, VA: Defense Technical Information Center, luglio 2013. http://dx.doi.org/10.21236/ada586278.

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Li, Yanhui, e Cuiju Hua. Comparison of the Efficacy and Subsequent Pregnancy Outcomes of High-intensity Focused Ultrasound and Uterine Artery Embolization in the Chinese Population: Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, ottobre 2022. http://dx.doi.org/10.37766/inplasy2022.10.0053.

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Review question / Objective: The combination of high-intensity focused ultrasound (HIFU), and uterine artery embolization (UAE) with uterine curettage has been proposed as a therapy strategy for cesarean scar pregnancy (CSP), which can provide a high success rate while reducing blood loss, adverse events, hospital time and cost. Therefore, we performed this meta-analysis to assess the effects of this combination therapy on the efficacy, safety, and pregnancy outcomes in patients with CSP. Eligibility criteria: (1) Study design: Cohort, case-control, or randomized controlled trials that compare the efficacy, safety, and recurrence of UAE combined with curettage and HIFU combined with uterine scraping in the treatment of cesarean section scar pregnancy. (2) Outcome: Success rate, blood loss, time of β-hCG normalization, adverse events, length of stay, hospital costs, menstrual recovery, re-pregnancy status, and pain score.

Jing, Naijie. Development of a Combination Therapy for Prostate Cancer by Targeting Stat3 and HIF-1alpha. Fort Belvoir, VA: Defense Technical Information Center, luglio 2012. http://dx.doi.org/10.21236/ada564134.

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