Bibliografie tematiche / Heri

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Letteratura scientifica selezionata sul tema "Heri"

Autore: Grafiati
Pubblicato: 4 giugno 2021
Ultima modifica: 1 febbraio 2022

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Articoli di riviste sul tema "Heri"

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Righetti, Pier Giorgio. "Bioanalysis: Heri, hodie, cras". ELECTROPHORESIS 34, n. 11 (23 aprile 2013): 1442–51. http://dx.doi.org/10.1002/elps.201300001.

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Raine, Cedric S. "Neuroimmunologia: Heri, hodie et cras". Journal of Neuroimmunology 216, n. 1-2 (30 novembre 2009): 1–2. http://dx.doi.org/10.1016/j.jneuroim.2009.09.021.

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&NA;. "HERI, HODIE, CRAS...YESTERDAY, TODAY, AND TOMORROW". Southern Medical Journal 89, n. 6 (giugno 1996): 641–43. http://dx.doi.org/10.1097/00007611-199606000-00021.

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Yuwanda, Herdika Sezar, e Imam Agus Faisol. "Analisis Pemanfaatan Opportunity Cost Pengolahan Limbah Tempe pada UD Tempe Heri di Pamekasan: Perspektif Going Concern Akuntansi". Wacana Equiliberium (Jurnal Pemikiran Penelitian Ekonomi) 8, n. 1 (22 giugno 2020): 35–41. http://dx.doi.org/10.31102/equilibrium.8.1.35-41.

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Tujuan penelitian ini adalah untuk mengetahui bagaimana pemanfaatan opportunity cost untuk keberlanjutan usaha UD Tempe Heri. Jenis metode penelitian yang digunakan adalah kualitatif deskriptif, dengan pengumpulan data menggunakan wawancara dan dokumentasi. Hasil penelitian menunjukkan bahwa berdasarkan aspek finansial, UD Tempe Heri memiliki kondisi keuangan yang baik (ditinjau dari tidak adanya kewajiban yang ditanggung, tidak ada penjualan aset atas kebutuhan yang mendesak, kemampuan meningkatkan aset yang cukup optimal, modal yang memadai, serta tingkat pendapatan yang meningkat dan stabil) serta tingkat efisiensi biaya yang cukup optimal. Sedangkan pada aspek non-finansial, UD Tempe Heri memiliki aktivitas bisnis yang menjanjikan (ditinjau dari tidak pernah mengalami kerugian hingga berkisar 50%, tingkat produksi tempe yang meningkat, dan segmentasi pasar yang luas) dan dampak aktivitas produksi terhadap lingkungan yang semakin baik. Sehingga, pemanfaatan opportunity cost pada limbah tempe dapat menunjang tingkat keberlanjutan usaha UD Tempe Heri.
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van den Herik, Jasper, e F. A. Muller. "Het cognibolistische Keijzerrijk". Algemeen Nederlands Tijdschrift voor Wijsbegeerte 108, n. 2 (28 maggio 2016): 183–87. http://dx.doi.org/10.5117/antw2016.2.heri.

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Mihailovich, Vasa D., e Milorad Pavić. "Unutrašnja strana vetra ili Roman o Heri i Leandru". World Literature Today 66, n. 3 (1992): 548. http://dx.doi.org/10.2307/40148518.

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Sodikin, Ali. "KONSTRUKSI PEMBERITAAN PARTAI DEMOKRAT DI MEDIA MASSA (Analisis Framing Pernyataan Pakar Komunikasi Politik di Kompas.com)". Kordinat: Jurnal Komunikasi antar Perguruan Tinggi Agama Islam 17, n. 2 (30 aprile 2019): 351–78. http://dx.doi.org/10.15408/kordinat.v17i2.9616.

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This research background on the news - reporting kompas.com of the Democratic Party. In the news, media kompas.com citing political communications expert Dr. Heri Budianto. The purpose of this study was to determine the Democrats construction news through the statement of political communications expert Dr. Heri Budianto in Mass Media Kompas.com. Basic theory in this research is the theory of social construction of reality consists of externalization, objectivation, and internalization by Berger and Luckman. Sociological theory of media by Shoemaker and Reese also be the basis of the theory in this study. The method used is framing analysis Entman models with indicators Define Problems, Causes Diagnose, Make Moral Judgment, and Treatment Recommendation. Subject / object in this study are statements of political communications expert Dr. Heri Budiantor published in the online media Kompas.com on the Democratic Party. These results indicate that by using framing approach Entman models can be seen that the statements Political Communication Specialists Dr. Heri Budianto contained in the online media Kompas.com framed in such a way with the selection of issues and highlighting the issue of political reality these parties.
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ALGIRDAS J., MANIUSHIS. "CONVERGENCE THEORY: A NEW READING (SCIENTIFIC HERI TAGE OF G.N. TSAGOLOV)". Scientific Works of the Free Economic Society of Russia 225, n. 5 (2020): 158–68. http://dx.doi.org/10.38197/2072-2060-2020-225-5-158-168.

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Based on the memoirs of the outstanding scientist, Doctor of Economics, Professor G.N. Tsagolov and his scientific heritage, the article examines the issues of the theory of convergence and the problems of its implementation at the present stage of development of society.
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Perales, Roberto, Daniel Pagano, Gang Wan, Brandon D. Fields, Arneet L. Saltzman e Scott G. Kennedy. "Transgenerational Epigenetic Inheritance Is Negatively Regulated by the HERI-1 Chromodomain Protein". Genetics 210, n. 4 (2 novembre 2018): 1287–99. http://dx.doi.org/10.1534/genetics.118.301456.

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Muna, Cut Nailil. "Integrated Marketing Communication pada Heri Pemad Management Studi Kasus International ARTJOG MMXIX". JURNAL TATA KELOLA SENI 6, n. 1 (8 luglio 2020): 1–17. http://dx.doi.org/10.24821/jtks.v6i1.4111.

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ABSTRAKPenelitian ini bertujuan menganalisis lebih lanjut penerapan Integrated Marketing Communication pada Festival Seni Rupa Kontemporer Internasional ARTJOG MMXIX yang diselenggarakan oleh Heri Pemad Management (selanjutnya disingkat HPM). Manfaat penelitian ini adalah memberikan kontribusi pemikiran bagi pengembangan pengelolaan manajemen seni dalam keberhasilannya meraih pasar. Untuk menjawab pokok masalah dalam penelitian ini, peneliti mengacu pada konsep komunikasi pemasaran terpadu model George dan Michael Belch (2011) yang meliputi advertising, sales promotion, personal selling, direct marketing, Public Relations and Publicity serta interactive marketing melalui tiga tahapan proses, yaitu perencanaan, implementasi, dan evaluasi. Penelitian dijalankan secara kualitatif dengan metode studi kasus. Pengumpulan data terbagi dua yaitu data primer melalui wawancara dan observasi; serta data sekunder melalui studi pustaka. Key informan dan informan yang dipilih berasal dari internal HPM dan pengunjung Festival ARTJOG MMXIX. Penelitian ini mampu menjelaskan bahwa HPM telah mengimplementasikan Integrated Marketing Communication melalui tahap perencanaan yang dimulai dari targeting, positioning, penetapan tujuan dan anggaran. Tahap implementasi, dilakukan perancangan pesan, pemilihan media, dan penerapan bauran komunikasi. Tahap evaluasi, dilakukan analisis untuk mengukur hasil akhir dari implementasi bauran IMC sekaligus mengambil tindakan korektif dalam penyelenggaraan festival tersebut. Kesimpulannya, HPM telah berhasil menerapkan konsep komunikasi pemasaran terpadu pada penyelenggaraan Festival Seni Rupa Kontemporer Internasional ARTJOG MMXIX. ABSTRACTThis research aims to further analyze the implementation of Integrated Marketing Communication at the International Contemporary Arts Festival of ARTJOG MMXIX organized by Heri Pemad Management (hereinafter abbreviated as HPM). The benefit of this research is to contribute to thinking for the development of art management in the success of achieving the market. To address the subject matter of this study, researchers refer to the concept of Integrated Marketing Communication George and Michael Belch (2011) model’s which include advertising, sales promotion, personal selling, direct marketing, Public Relations and Publicity and interactive marketing through three stages of the process, planning, implementation and evaluation. Research is conducted qualitatively with case study methods. Two data collection is the primary data through interviews and observations; and secondary data through library studies. Key informant and informant are selected from the internal HPM and visitors Festival ARTJOG MMXIX. The research can explain that HPM has implemented Integrated Marketing Communication through the planning phase starting from targeting, positioning, goal setting and budget. Implementation stage, message design, media selection and communication mix application. Evaluation stage analyzed to measure the outcome of the implementation of IMC mix and take corrective action in the implementation of the festival. In conclusion, HPM has successfully adopted the concept of integrated marketing communication at the International Contemporary Art Festival of ARTJOG MMXIX.
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Tesi sul tema "Heri"

1

Ingham, Susan Helen School of Art History &amp Theory UNSW. "Powerlines: alternative art and infrastructure in Indonesia in the 1990s". Awarded by:University of New South Wales. School of Art History and Theory, 2007. http://handle.unsw.edu.au/1959.4/31257.

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This thesis investigates why an alternative visual art and arts infrastructure developed in Indonesia during the 1990s. Initially alternative exhibition spaces developed in response to a lack of outlets through the existing commercial galleries and in reaction to the cultural hegemony of Suharto???s regime, which failed to provide infrastructure for modern art. ???Alternative??? will be extended here to describe an art and an arts infrastructure that became an influential system of power, the gatekeeper for the Indonesian arts community to the international art forum. The background of Alternative art is considered, its sources being in the protest of the New Art Movement, Gerakan Seni Rupa Baru, in the 1970s and an on-going art student rebellion against the modern and decorative art taught in the art academies. Contemporary artists sought content that reflected the many issues confronting Indonesian society, and rejected that art focusing on formal properties particularly in painting, which, by avoiding contention, served the purposes of Suharto???s regime. Particular examples are explored to define the lines of power that evolved: firstly the alternative gallery, Cemeti, and secondly the curator, Jim Supangkat and his theoretical justification for Indonesian contemporary art for the international forum. Finally the career structure of Heri Dono is examined to identify the mechanisms for artistic success through international contacts. This investigation concludes that power and influence became dependent on recognition in the international forum. Western and later Asian institutions, in selecting work for the high profile survey exhibitions proliferating in the 1990s, worked almost exclusively with this network. Their preference was for installation art that reflected the socio-political context in which it was made, and the few artists who were selected developed careers very different from their colleagues in Indonesia, some becoming nomadic art stars. This relationship between the Indonesian and the international art network has gained recognition for Indonesian contemporary art and an outlet for suppressed issues and marginalised people, but did not provide a fully balanced representation of Indonesian culture and reiterated the systems and paradigms of the West in relation to Asian art.
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2

Yglesias-Liberatore, Anna. "The Relationship between Art and the Development of the Self Concept in Higher Education as Measured by the HERI College Senior Survey 2006". Thesis, Saint Peter's University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10811626.

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Art is part of our natural human behavior. For four years, college students go through several developmental stages. Art in higher education can become a fundamental part of students’ behavior. Like language and laughter, art is a basic part of the self-concept and development. Experimental learning is one outline of the many comprehensive theories of college student development that can be used as measuring tools for administrators, professors, institutional policies, improvements, and practices. The college environment is a place that fosters outcomes of growth and challenges, and as a result, support is needed because a student lives different levels of maturity within social contexts. College can be an “advisory circle” as the environment provides education, support, realization, awareness, and knowledge that develop strength for the future and the world ahead. The purpose of this study is to examine the relationship between art and non-art majors and the development of the self-concept in higher education. The data is derived from senior students at four-year institutions who completed the college senior survey from the Cooperative Institutional Research Program (CIRP) of the Higher Education Research Institute (HERI) of UCLA. Descriptive statistics, cross-tabulations, and chi-square testing were performed to examine the relationship between art and development of the self-concept in higher education. The major themes of the college senior survey are academic and social adjustment, sources of satisfaction and dissatisfaction, academic, residential and employment experiences, plans for the next academic year, patterns of behavior, life goals and self-concepts, and feelings of personal success. The findings of this study suggest that art majors and art careers have a good self-concept when studying the controlled variables of gender, race/ethnicity, GPA, art majors/non-art majors, career occupation, institution type, and control. The independent variables that are the HERI standards of student/faculty interactions, educational environment/climate, campus environment satisfaction, academic achievement/change, and learning styles/self-rating were also examined alongside the dependent variables of character and development of art and non-art majors’ self-concept, self-esteem, ideal self, and self-image.

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Thomas, Gaëlle. "Ciblage de l'entité HER2/HER3 par des anticorps monoclonaux pour le traitement des cancers du pancréas exprimant faiblement HER2". Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON1T011.

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Avec un taux de survie à 5 ans inférieur à 5%, l'adénocarcinome pancréatique (PDAC) est l'un des cancers les plus agressifs et pour lequel les thérapies existantes sont largement insuffisantes. Ce cancer est caractérisé par un tissu fibreux dense et un stroma très développé, en constante interaction avec la tumeur, favorisant le développement d'un environnement propice à la progression tumorale. Actuellement, la gemcitabine est la seule chimiothérapie approuvée capable de prolonger légèrement la survie des patients. Une thérapie ciblée dirigée contre l'EGFR, l'erlotinib, a prouvé que le ciblage de cette famille pourrait être une stratégie intéressante dans cette pathologie mais qu'une sélection des patients était indispensable pour augmenter les réponses thérapeutiques. Deux récepteurs de cette famille, HER2 et HER3, dimérisent pour former une entité particulièrement agressive et impliquée dans la croissance tumorale des PDACs. Diverses techniques récemment développées sont utilisées pour quantifier ces dimères, afin d'étudier leur rôle, mais également pour tenter de les cibler, et empêcher leur signalisation dans différents cancers. A l'heure actuelle, le pertuzumab est le seul anticorps monoclonal dirigé contre le récepteur HER2, capable de bloquer sa dimérisation, et utilisé en clinique. Dans un premier temps, nous nous sommes intéressés au rôle de HER3 en tant que cible et marqueur pronostique de l'effet du pertuzumab sur les PDAC exprimant faiblement HER2. Puis dans une deuxième partie, nous avons étudié et comparé les effets de différents anticorps monoclonaux dirigés contre HER2 et/ou HER3, sur la prolifération tumorale de tumeurs du pancréas. L'ensemble de ces résultats a permis d'établir que le ciblage du dimère HER2/HER3 s'avère être une stratégie prometteuse pour inhiber la croissance des tumeurs du pancréas exprimant faiblement HER2, et que le récepteur HER3 pourrait être un marqueur pronostique de l'effet du pertuzumab
With a 5-year survival lower than 5%, PDAC is one of the worst cancers in terms of mortality, and for which existing therapies are unsatisfying. This cancer is characterized by a dense fibrotic tissue and an over-developed stroma, in continual interaction with the tumor, promoting the development of an ideal environment for tumor progression.To date, gemcitabine is the only approved chemotherapy able to slightly increase patients' survival. The use of erlotinib, an EGFR targeting therapy, underlined that EGFR family targeting could be an interesting treatment strategy in this pathology, but that a better patients' selection is essential to increase therapeutic response. Two receptors of this family, HER2 and HER3, are able to dimerize to consititute an aggressive entity, involved in PDAC tumoral growth. Various recently developed techniques are used to quantify those dimers, in order to study their role, but also to target them and block their signaling in cancer cells. Pertuzumab is currently the only HER2-targeting monoclonal antibody able to block its dimerization and used in clinic. We first evaluated the role of HER3 as therapeutic target and prognostic marker of pertuzumab efficacy on HER2-low expressing PDACs. We then studied and compared therapeutic effects on pancreatic tumor proliferation of different antibodies targeting HER2 and/or HER3. Taken together, those results demonstrated that HER2/HER3 dimers targeting is a promising strategy to inhibit low-HER2 expressing pancreatic tumor growth, and that HER3 could be a pronostic marker for pertuzumab efficacy in those cancers
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Kammertöns, Christoph. "Chronique scandaleuse : Henri Herz - ein Enfant terrible in der französischen Musikkritik des 19. Jahrhunderts /". Essen : Die Blaue Eule, 2000. http://catalogue.bnf.fr/ark:/12148/cb37210862n.

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Lindhardt, Rasmussen Merete. "Dannelse af religiøsitet : en redegørelse for udvalgte teorier om dannelsen af barnets religiøsitet og gudsbillede, samt - i forlængelse heraf - en drøftelse af, hvorvidt der heri indgår et element af "naturlig religion" : Cand. Theol. speciale /". [Merete Lindhardt Rasmussen], 2001. http://home19.inet.tele.dk/clch/merete/.

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Sollome, James Jerome. "Heregulin Activates a Novel HER2/HER3-MTK1-GIT1/ERK1/2 MAPK Signaling Pathway". Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/315554.

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Human MAP3K4 (MTK1) functions upstream of mitogen activated protein kinases (MAPKs). In the studies presented herein, MTK1 is shown to be required for human epidermal growth factor receptor 2/3 (HER2/HER3)-heregulin beta1 (HRG) induced extracellular acidification and cell migration in MCF-7 breast cancer cells. Furthermore, it was shown that HRG stimulation leads to association of MTK1 with tyrosine phosphorylated HER3 in MCF-7 and T-47D breast cancer cells. The MTK1/HER3 association was dependent on HER2 activation and was decreased by pre-treatment with the HER2 inhibitor, lapatinib. Furthermore, HER2 does not directly associate with MTK1, but phosphorylates HER3 transiently. MTK1 also has a role in the ERK1/2 MAPK signaling pathway in response to heregulin (HRG) stimulation in T-47D and MCF-7 breast cancer cells. In addition to MTK1, Shc, Grb2 and GIT1 proteins are all involved in the ERK1/2 MAPK pathway in response to growth factor stimulation. MTK1 was also shown to associate with activated ERK1/2, GIT1, Shc, Grb2 and p85 of PI3K in response to heregulin stimulation. ERK1/2 kinase activity is involved in aberrant signaling that leads breast cancer progression. GIT1 is a scaffolding protein that is linked to growth factor mediated ERK1/2 signaling in cell migration. Moreover, we also identify the actin interacting region (AIR) on MTK1 and disruption of actin cytoskeletal polymerization with cytochalasin D inhibited the interaction between HER3 and MTK1, indicating that f-actin (which is needed for cell migration) is required for the MTK1/HER3 association. Additionally, HRG stimulation leads to extracellar acidification that is independent of cellular proliferation. HRG induced extracellular acidification is significantly inhibited when MTK1 is knocked down in MCF-7 cells. Similarly, pre-treatment with lapatinib significantly decreased HRG induced extracellular acidification. Extracellular acidification is linked with cancer cell migration. We performed scratch assays that show HRG induced cell migration in MCF-7 cells. Knockdown of MTK1 significantly inhibited HRG induced cell migration. Furthermore, pre-treatment with lapatinib also significantly decreased cell migration. Cell migration is required for cancer cell metastasis, which is the major cause of cancer patient mortality. We identify MTK1 in the HER2/HER3-HRG mediated extracellular acidification and cell migration pathway in breast cancer cells.
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Hashimoto, Kenji. "Investigating a role of HER3 in anti-HER2 target therapy in breast cancer". Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:39025871-f32f-4e38-bd14-c13dbc9301f6.

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Background HER2-positive breast cancer is a poor prognostic subgroup, even if treated with anti-HER2 directed therapy. Trastuzumab is an important HER2-targeting antibody but only limited patients respond to this drug, and acquired resistance is a common problem. HER3 has been shown to be a key candidate in mediating resistance to trastuzumab and other ErbB inhibitors. The aims of the project are to investigate the resistance mechanisms and the relevant biomarkers in relation to trastuzumab treatment and resistance in HER2-positive breast cancer, in particular, HER3 subcellular localisation and HER3 phosphorylation. Methods Effects of trastuzumab on HER3 subcellular localisation and HER3 phosphorylation in relation to MET receptor were studied using western blots, nuclear fractionation, confocal microscopy, and immunoprecipitation in a panel of HER2-positive cell lines, including SKBr3 and BT474 breast cancer cells in which trastuzumab resistance was induced by long-term drug exposure. Effects of drug and knockdown experiments were tested by cell viability and proliferation assays. HER3 and MET expression was assessed by immunohistochemistry in xenograft tumours and human tissue samples, and clinical impact was assessed in different cohorts of HER2-positive breast cancer patients. Results Acquired trastuzumab resistant SKBr3 cells showed an increase of nuclear HER3100kD, which was derived from C-terminus of HER3. Nuclear HER3100kD could be due to the proteolytic cleavage of HER3 since it was reduced by ADAM17 or gamma-secretase inhibitor. In a panel of HER2-positive cell lines and xenograft samples, nuclear HER3 was observed only in the resistant cells. In addition, nuclear HER3 was associated with poor progression-free and overall survivals in HER2-positive breast cancer patients. It was also found that HER3 phosphorylation was maintained in acquired trastuzumab resistant cells, which was contributed by the ligand independent interaction of MET and HER3. Higher MET expression was associated with better overall survival in HER2-positive, breast cancer patients who were not treated with trastuzumab. Conclusions Nuclear HER3 was found in trastuzumab resistant cells and appeared to result from HER3 proteolytic cleavage mediated by ADAM17 and gamma-secretase. Further studies are required to investigate its mechanism and to identify the HER3 cleavage sites. MET was a key factor in maintaining HER3 phosphorylation during trastuzumab resistance. Lastly, nuclear HER3 and MET could be two potential biomarkers in HER2-positive breast cancer.
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Maslak, Kerstin [Verfasser]. "Untersuchung zur synergistischen Wirkung von Lapatinib (GW 2016), einem potenten dualen HER1-HER2-Tyrosinkinaseinhibitor, und Fulvestrant, einem Östrogenrezeptorantagonisten, in HER2 und nicht HER2 überexprimierenden Brustkrebszellen / Kerstin Maslak". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1030290946/34.

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Göstring, Lovisa. "Cellular Studies of HER-family Specific Affibody Molecules". Doctoral thesis, Uppsala universitet, Enheten för biomedicinsk strålningsvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-156730.

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The human epidermal growth-factor like receptor (HER) family of receptor tyrosine kinases are important targets for cancer therapy. The family consists of four members - EGFR, HER2, HER3 and HER4 - that normally transfer stimulatory signals from extracellular growth factors to the intracellular signalling network. Over-activation of these receptors leads to uncontrolled cell proliferation and is seen in several types of tumours. The aim of the studies reported in this thesis was to study the uptake and effects of affibody molecules against EGFR, HER2 and HER3 in cultured cells. Affibody molecules are affinity proteins originally derived from one of the domains of protein A, and their small size and robust structure make them suitable agents for tumour targeting and therapy. Papers I and II of this thesis concern EGFR-specific affibody molecules, which were shown to be more similar to the antibody cetuximab than the natural ligand EGF in terms of cellular uptake, binding site and internalisation rate. In addition, fluorescence-based methods for the quantification of internalisation were evaluated. In the studies reported in papers III and IV, HER2-specific affibody molecules were utilised as carriers of radionuclides. Paper III reports that different cell lines exhibit different radiosensitivities to 211At-labelled affibody molecules; radiosensitivity was found to correlate with cell geometry and the rate of internalisation. Paper IV discusses the use of 17-AAG, an agent that induces HER2 internalisation and degradation, to force the internalisation of 211At- and 111In-labelled affibody molecules. Papers V and VI describe the selection and maturation of HER3-specific affibody molecules, which were found to compete with the receptor’s natural ligand, heregulin, for receptor binding. These affibody molecules were demonstrated to inhibit heregulin-induced HER3 activation and cell proliferation. The studies summarised in this paper will hopefully contribute to a better understanding of these affibody molecules and bring them one step closer to being helpful tools in the diagnosis and treatment of cancer.
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Mohd, Nafi Siti Norasikin. "The role of HER4 in relation to trastuzumab resistance and prognosis in HER2 positive breast cancer". Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:4b27e551-806e-4463-8841-7091796696d3.

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Background Trastuzumab resistance imposes a major limitation to the successful treatment of HER2 positive breast cancer. The expression of HER4 and its prognostic value is controversial in breast cancer. Furthermore, its role in trastuzumab treatment and resistance in HER2 positive breast cancer has not been reported. Methods The effects of trastuzumab on HER4 cleavage and its localisation were studied in both parental and trastuzumab-resistant SKBR3 and BT474 cells using western blot, RT-PCR, nuclear fractionation and confocal microscopy. Tissue microarrays consisting of a cohort of HER2 positive breast cancer patients were stained for HER4 by immunohistochemistry and the results were correlated with patients’ outcome. This study also assessed HER4 expression in the tumor samples from a window study of trastuzumab alone or in combination with neoadjuvant chemotherapy in HER2 positive breast cancer patients. Results Trastuzumab treatment upregulated HER4 mRNA, and increased expression of both 80 and 180 kDa HER4 protein isoforms, and induced nuclear translocation of 80kDa HER4 protein isoforms, which the results similar to heregulin stimulation. This was also seen in trastuzumab resistant cells although HER480kDa and nuclear HER4 decreased upon overnight withdrawal of trastuzumab in resistant cell lines. In addition, knockdown of HER4 protein expression by specific siRNAs increased trastuzumab sensitivity and reversed trastuzumab resistance in SKBR3 and BT474 cells, confirming the importance of HER4 in trastuzumab response. This study also showed that trastuzumab-induced HER4 nuclear translocation is due to HER4 activation and cleavage since γ-secretase inhibitor (GSi) and neratinib prevented the process when combined with trastuzumab treatment, correlating with an increased apoptosis and decreased cell viability. There was also increased nuclear HER4 expression in tumors from both BT474 xenografts and from patients with breast cancer treated with trastuzumab monotherapy. Furthermore, nuclear HER4 predicted poor clinical response to trastuzumab monotherapy in patients undergoing a window study and was a poor prognostic factor in HER2 positive breast cancer. Conclusions This study suggests HER4 activation, cleavage and nuclear translocation play a key role in trastuzumab resistance in HER2 positive breast cancer. Nuclear HER4 could be a novel predictive and prognostic biomarker in HER2 positive breast cancer patients.
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Più fonti

Libri sul tema "Heri"

1

Heri. Dar es Salaam, Tanzania: Mkuki na Nyota Publishers, 2002.

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2

Dono, Heri. Heri-donology. Yogyakarta, Indonesia: Jogja Gellery, 2009.

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3

Heri subira. Nairobi: Oxford University Press, 2010.

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4

Gordon, V. Jane. Kwa heri. Edinburgh: Pentland Press, 1996.

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Wiyanto, Hendro. Heri Dono. Jakarta, Indonesia: Nadi Gallery, 2004.

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Adha ya heri. Dar es Salaam: Taasisi ya Uchunguzi wa Kiswahili, Chuo Kikuu cha Dar es Salaam, 2008.

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Shayo, Daudi P. Adha ya heri. Dar es Salaam: Taasisi ya Uchunguzi wa Kiswahili, Chuo Kikuu cha Dar es Salaam, 2008.

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Matei, Assumpta K. Chozi la heri. Nairobi, Kenya: One Planet Publishing & Media Services Limited, 2014.

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MIKROUTSIKOS, Thanos. Ola apo heri Kamena. Athens: Minos, 1988.

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Sinou, Kira. To heri sto vitho. Athens: Kastaniotis, 1986.

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Capitoli di libri sul tema "Heri"

1

Stolze, Radegundis. "Hermeneutics and translation". In Handbook of Translation Studies, 141–46. Amsterdam: John Benjamins Publishing Company, 2010. http://dx.doi.org/10.1075/hts.1.her1.

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Van de Craen, Piet. "Hermeneutics". In Handbook of Pragmatics, 1–7. Amsterdam: John Benjamins Publishing Company, 1996. http://dx.doi.org/10.1075/hop.1.her1.

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Herbst, Wolfgang. "389 Ein reines Herz, Herr, schaff in mir". In Liederkunde zum Evangelischen Gesangbuch. Heft 26, 48–49. Göttingen: Vandenhoeck & Ruprecht, 2020. http://dx.doi.org/10.13109/9783666500091.48.

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SCHNAPPER, LAURE. "Bernard Ullman-Henri Herz:". In The Musician as Entrepreneur, 1700-1914, 130–44. Indiana University Press, 2004. http://dx.doi.org/10.2307/j.ctv19m65gs.9.

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Rugutt, John K., Lucille L. T. Eckrich e Caroline C. Chemosit. "Internet Technology Levels in a Higher Education Teaching and Learning Environment". In Research Perspectives and Best Practices in Educational Technology Integration, 163–77. IGI Global, 2013. http://dx.doi.org/10.4018/978-1-4666-2988-2.ch009.

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Abstract (sommario):
The authors of this study utilized the discriminant function analysis using extreme student groups (top and bottom quartiles) defined by students’ internet technology scores to develop a model that best predicts group membership of the low and high internet technology levels among college students. The sample for the study was drawn from a Midwestern doctoral university and consisted of a random sample of senior year undergraduate students (n = 537). The instrument for the study used items from a 2000 College Student Survey (HERI, 2000). The response format for most instrument subscale items used in this study was of the Likert-type. Results of the discriminant analysis showed that students’ classification into low or high internet technology groups based on the institutional, behavioral, and personality variables can accurately be done. The lowest total percent correctly classified was at 72% while the highest total percent correctly classified was 74%. The variables that made significant differences included: student faculty interaction, student support services, quality of instruction and college experience, interpersonal relations and leadership, and student extra effort in learning.
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Trzeciak, Miriam. "„Here your child can be a hero, too“". In Von "Bibi Blocksberg" bis "TKKG", 94–110. Verlag Barbara Budrich, 2016. http://dx.doi.org/10.2307/j.ctvhn0b8z.9.

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Boehm, Deborah A. "Here–Not Here". In Intimate Migrations, 127–42. NYU Press, 2012. http://dx.doi.org/10.18574/nyu/9780814789834.003.0008.

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Boehm, Deborah A. "Here/Not Here:". In Everyday Ruptures, 161–73. Vanderbilt University Press, 2011. http://dx.doi.org/10.2307/j.ctv16f6hv3.12.

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"6 Herz Herz". In I care Anatomie Physiologie, a cura di Frank Schmitz e Karin Schwarz. Stuttgart: Georg Thieme Verlag, 2020. http://dx.doi.org/10.1055/b-0040-176306.

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Behrends, Jan C., Josef Bischofberger, Rainer Deutzmann, Heimo Ehmke, Stephan Frings, Stephan Grissmer, Markus Hoth et al. "4 Herz Herz". In Duale Reihe Physiologie. 4a ed. Stuttgart: Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/b-0041-180458.

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Atti di convegni sul tema "Heri"

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"CollaborateCom 2007 Heri Ramampiaro, NTNU, Norway - Performance and scalability". In 2007 International Conference on Collaborative Computing: Networking, Applications and Worksharing (CollaborateCom 2007). IEEE, 2007. http://dx.doi.org/10.1109/colcom.2007.4553852.

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"CollaborateCom 2007 Session chair: Heri Ramampiaro, NTNU, Norway - collaborative applications". In 2007 International Conference on Collaborative Computing: Networking, Applications and Worksharing (CollaborateCom 2007). IEEE, 2007. http://dx.doi.org/10.1109/colcom.2007.4553864.

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3

Ren, Zeyu, Chengxu Zhou, Songyan Xin e Nikos Tsagarakis. "HERI hand: A quasi dexterous and powerful hand with asymmetrical finger dimensions and under actuation". In 2017 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS). IEEE, 2017. http://dx.doi.org/10.1109/iros.2017.8202175.

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Ren, Zeyu, Navvab Kashiri, Chengxu Zhou e Nikos G. Tsagarakis. "HERI II: A Robust and Flexible Robotic Hand based on Modular Finger design and Under Actuation Principles". In 2018 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS). IEEE, 2018. http://dx.doi.org/10.1109/iros.2018.8594507.

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Kato, Hiroaki, Tokuzo Arao, Kazuko Matsumoto, Yoshihiko Fujita, Hideharu Kimura, Kouhei Nishiki, Osamu Shiraishi et al. "Abstract 4: Gene amplification of EGFR, HER2, HER3 and HER4 in esophageal squamous cell carcinoma". In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4.

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Hanker, AB, JP Koch, D. Ye, G. Sliwoski, J. Sheehan, LN Kinch, M. Red Brewer et al. "Abstract PD3-05: Co-occurring gain-of-function mutations in HER2 and HER3 cooperate to enhance HER2/HER3 binding, HER-dependent signaling, and breast cancer growth". In Abstracts: 2018 San Antonio Breast Cancer Symposium; December 4-8, 2018; San Antonio, Texas. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-pd3-05.

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Lamerdin, Jane, Abhishek Saharia, Jennifer Lin-Jones, Mimi Nguyen, Hyna Fabionar, Sangeetha Gunturi, Abha Srivastava e Tom Wehrman. "Abstract 3742: Detection of EGFR, HER2, HER3 and HER4 homodimerization and heterodimerization using EFC-based cellular assays". In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3742.

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Garrett, Joan T., Cammie R. Sutton, Carl Uli Bialucha, Seth A. Ettenberg, Jerry Wallweber, Lisa DeFazio-Eli e Carlos L. Arteaga. "Abstract 5461: A HER3 antibody that blocks ligand-independent HER2-HER3 dimerization sensitizes to HER2 and PI3K inhibitors ." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5461.

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Hoe, Nicholas, Michael Mateling, Yating Ma, Kelly Jin, JinYao Zhou, Richard Kirkland, Crystal Kuy, Xinjun Liu, Phillip Kim e Sharat Singh. "Abstract 5632: MEK inhibition leads to elevated HER3:PI3K in EGFR or HER2 driven cancer through feedback induction of HER1:3 and HER2:3 dimers." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5632.

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Takagi, S., A. Hayashi e Y. Ohta. "HER2 and HER3 cooperatively regulate tumor cell growth and determine sensitivity to the HER kinase inhibitor TAK-285." In CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-3155.

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Rapporti di organizzazioni sul tema "Heri"

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Disis, Mary L. Phase II Study of a HER-2/neu (HER2) Intracellular Domain (ICD) Peptide-Based Vaccine Administered to Stage IIIB and IV HER2 Positive Breast Cancer Patients Receiving Trastuzumab Monotherapy. Fort Belvoir, VA: Defense Technical Information Center, maggio 2008. http://dx.doi.org/10.21236/ada486630.

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2

Martínez-García, A., e A. Gómez-Aguilar. Magallanes: building the hero. Revista Latina de Comunicación Social, febbraio 2019. http://dx.doi.org/10.4185/rlcs-2019-1348en.

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Marshak, David. Portlet Standards Are Here. Boston, MA: Patricia Seybold Group, novembre 2003. http://dx.doi.org/10.1571/ta11-26-03.

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4

Tinsley, David. The Hero at Rest. Portland State University Library, gennaio 2000. http://dx.doi.org/10.15760/etd.6826.

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Miller, Phillip Isaac, e Lawrence Mark Hull. Ti Hemi boombox experiment. Office of Scientific and Technical Information (OSTI), maggio 2015. http://dx.doi.org/10.2172/1179848.

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Freeman, A. E. Gene, Joe Detrick e David H. Kelley. Dairy Breeding Research Herd. Ames (Iowa): Iowa State University, gennaio 2004. http://dx.doi.org/10.31274/ans_air-180814-25.

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Nugroho, Heru Santoso Wahito. HERU SANTOSO WAHITO NUGROHO. FORIKES, 2021. http://dx.doi.org/10.33846/hswn.

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Disis, Mary L. Phase II Study of HER-2/neu Intracellular Domain Peptide-Based Vaccine Administered to Stage IV HER2 Positive Breast Cancer Patients Receiving Trastuzumab. Fort Belvoir, VA: Defense Technical Information Center, maggio 2006. http://dx.doi.org/10.21236/ada456015.

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Disis, Mary L. Study of HER-2/neu Intracellular Domain Peptide-Based Vaccine Administered to Stage IV HER2 Positive Breast Cancer Patients Receiving Trastuzumab. Phase 2. Fort Belvoir, VA: Defense Technical Information Center, maggio 2009. http://dx.doi.org/10.21236/ada505213.

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Disis, Mary L. Phase II Study of HER-2/neu Intracellular Domain Peptide-Based Vaccine Administered to Stage IV HER2 Positive Breast Cancer Patients Receiving Trastuzumab. Fort Belvoir, VA: Defense Technical Information Center, maggio 2007. http://dx.doi.org/10.21236/ada471552.

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